Development of humanized steroid and xenobiotic receptor mouse by homologous knock-in of the human steroid and xenobiotic receptor ligand binding domain sequence

Journal of Toxicological Sciences

Volumn 37, Issue 2, 2012, Pages 373-380

  Igarashi, Katsuhide ^a   Kitajima, Satoshi ^a   Aisaki, Ken Ichi ^a   Tanemura, Kentaro ^a   Taquahashi, Yuhji ^a   Moriyama, Noriko ^a   Ikeno, Eriko ^a   Matsuda, Nae ^a   Saga, Yumiko ^b,c   Blumberg, Bruce ^d   Kanno, Jun ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^b NATIONAL INSTITUTE OF GENETICS   (Japan)

^c GRADUATE UNIVERSITY FOR ADVANCED STUDIES   (Japan)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Humanized mouse; Knock in mouse; Ligand binding domain; Pregnane X receptor; Steroid and xenobiotic receptor

Indexed keywords

CARBOXYLESTERASE; CHIMERIC PROTEIN; CYTOCHROME P450 3A11; MESSENGER RNA; PREGNANE X RECEPTOR; RIFAMPICIN;

ARTICLE; GENE EXPRESSION; KIDNEY; LIGAND BINDING; LIVER; LUNG; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMALL INTESTINE; STOMACH; TOXICITY TESTING;

MURINAE; RODENTIA;

EID: 84859368651     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.37.373     Document Type: Article

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