The reconstituted 'humanized liver' in TK-NOG mice is mature and functional

Biochemical and Biophysical Research Communications

Volumn 405, Issue 3, 2011, Pages 405-410

  Hasegawa, Masami ^a,b,c   Kawai, Kenji ^a   Mitsui, Tetsuya ^c   Taniguchi, Kenji ^a,c   Monnai, Makoto ^a,d   Wakui, Masatoshi ^a,b   Ito, Mamoru ^a   Suematsu, Makoto ^b   Peltz, Gary ^e   Nakamura, Masato ^a,f   Suemizu, Hiroshi ^a  

^a CENTRAL INSTITUTE FOR EXPERIMENTAL ANIMALS   (Japan)

^b KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c CHUGAI PHARMACEUTICAL CO LTD   (Japan)

^d Chugai Research Institute for Medical Science Inc   (Japan)

^e STANFORD UNIVERSITY   (United States)

^f TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Drug metabolism; Herpes simplex virus type 1 thymidine kinase (HSVtk); Humanized mouse; Liver reconstitution

Indexed keywords

GANCICLOVIR; THYMIDINE KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MATURATION; CONTROLLED STUDY; DRUG TRANSFORMATION; EXPERIMENTAL STUDY; GENE EXPRESSION; GENE EXPRESSION PROFILING; HEPATOCYTE TRANSPLANTATION; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN CELL; HUMAN TISSUE; HUMANIZED LIVER; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; LIVER; LIVER CELL; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; TK NOG MOUSE; TRANSGENE; TRANSGENIC MOUSE;

ANIMALS; CARRIER PROTEINS; GANCICLOVIR; GENE EXPRESSION PROFILING; HEPATOCYTES; HERPESVIRUS 1, HUMAN; HUMANS; LIVER; LIVER REGENERATION; MICE; MICE, TRANSGENIC; MODELS, ANIMAL; THYMIDINE KINASE;

HUMAN HERPESVIRUS 1; MUS;

EID: 79951576827     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.01.042     Document Type: Article

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