In vivo responses of the human and murine pregnane X receptor to dexamethasone in mice

Drug Metabolism and Disposition

Volumn 38, Issue 7, 2010, Pages 1046-1053

  Scheer, Nico ^a   Ross, Jillian ^b   Kapelyukh, Yury ^b   Rode, Anja ^a   Wolf, C Roland ^b,c  

^a TaconicArtemis   (Germany)

^b CXR Biosciences Ltd   (United Kingdom)

^c UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 2B; CYTOCHROME P450 2B10; CYTOCHROME P450 3A; DEXAMETHASONE; PREGNANE X RECEPTOR; RIFAMPICIN; UNCLASSIFIED DRUG; CYP2B10 PROTEIN, MOUSE; CYP3A PROTEIN, MOUSE; CYTOCHROME P450; STEROID MONOOXYGENASE; STEROID RECEPTOR; UNSPECIFIC MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DETOXIFICATION; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG MEGADOSE; DRUG METABOLISM; DRUG SENSITIVITY; GENE DELETION; GENE LOCUS; IN VIVO STUDY; LIVER TOXICITY; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; TRANSGENIC MOUSE; TREATMENT RESPONSE; WILD TYPE; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HUMAN; KNOCKOUT MOUSE; LIVER; PATHOLOGY; TRANSFORMED CELL LINE;

MAMMALIA; MURINAE; MUS; MUS MUSCULUS;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CELL LINE, TRANSFORMED; CYTOCHROME P-450 ENZYME SYSTEM; DEXAMETHASONE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; RECEPTORS, STEROID; RIFAMPIN; STEROID HYDROXYLASES;

EID: 77953734202     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.109.031872     Document Type: Article

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