Chimeric mice with humanized livers: A unique tool for in vivo and in vitro enzyme induction studies

International Journal of Molecular Sciences

Volumn 15, Issue 1, 2014, Pages 58-74

  Kakuni, Masakazu ^a   Yamasaki, Chihiro ^a   Tachibana, Asato ^a   Yoshizane, Yasumi ^a   Ishida, Yuji ^a,b   Tateno, Chise ^a,b  

^a PhoenixBio USA Corporation   (Japan)

^b HIROSHIMA UNIVERSITY   (Japan)

Author keywords

3 methylcholanthrene; Humanized animal model; Liver; P450 induction; Rifampicin

Indexed keywords

3-METHYLCHOLANTHRENE; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 3A4; CYTOKERATIN 18; CYTOKERATIN 8; RIFAMPICIN; UNCLASSIFIED DRUG; 3 METHYLCHOLANTHRENE; CYTOCHROME P450 3A; MESSENGER RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CELL COUNT; CELL VIABILITY; CHILD; CHIMERA; CONTROLLED STUDY; ENZYME INDUCTION; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LIQUID CHROMATOGRAPHY; LIVER; MALE; MOUSE; NONHUMAN; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; SCHOOL CHILD; TANDEM MASS SPECTROMETRY; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; ENZYMOLOGY; GENETICS; HALF LIFE TIME; LIVER CELL; METABOLISM;

ANIMALIA; MUS;

ANIMALS; CHIMERA; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 CYP3A; ENZYME INDUCTION; HALF-LIFE; HEPATOCYTES; HUMANS; IMMUNOHISTOCHEMISTRY; KERATIN-18; KERATIN-8; LIVER; METHYLCHOLANTHRENE; MICE; RIFAMPIN; RNA, MESSENGER;

EID: 84891063685     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms15010058     Document Type: Article

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