Human hepatic stem cells transplanted into a fulminant hepatic failure Alb-TRECK/SCID mouse model exhibit liver reconstitution and drug metabolism capabilities

Stem Cell Research and Therapy

Volumn 6, Issue 1, 2015, Pages

  Zhang, Ran Ran ^a   Zheng, Yun Wen ^a,b   Li, Bin ^c   Tsuchida, Tomonori ^a   Ueno, Yasuharu ^a   Nie, Yun Zhong ^a   Taniguchi, Hideki ^a,d  

^a YOKOHAMA CITY UNIVERSITY   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^d YOKOHAMA CITY UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; DEBRISOQUINE; DIPHTHERIA TOXIN; HUMAN ALBUMIN; KETOPROFEN;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG METABOLISM; FETUS; FULMINANT HEPATIC FAILURE; GENE EXPRESSION; HEPATIC STEM CELL TRANSPLANTATION; HUMAN; HUMAN CELL; IN VIVO STUDY; LIVER CELL; MOUSE; MOUSE MODEL; NONHUMAN; PRIORITY JOURNAL; STEM CELL TRANSPLANTATION; SURVIVAL RATE; ANIMAL; CELL CULTURE; CHEMICALLY INDUCED; CHIMERA; CYTOLOGY; DISEASE MODEL; DRUG INACTIVATION; KNOCKOUT MOUSE; LIVER; LIVER FAILURE, ACUTE; LIVER REGENERATION; METABOLISM; PHYSIOLOGY; PROCEDURES; SCID MOUSE; STEM CELL; TRANSPLANTATION; XENOGRAFT;

MUS;

ANIMALS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; CHIMERA; DEBRISOQUIN; DIPHTHERIA TOXIN; DISEASE MODELS, ANIMAL; HEPATOCYTES; HUMANS; INACTIVATION, METABOLIC; KETOPROFEN; LIVER; LIVER FAILURE, ACUTE; LIVER REGENERATION; MICE; MICE, KNOCKOUT; MICE, SCID; STEM CELL TRANSPLANTATION; STEM CELLS; TRANSPLANTATION, HETEROLOGOUS;

EID: 84928530165     PISSN: None     EISSN: 17576512     Source Type: Journal    
DOI: 10.1186/s13287-015-0038-9     Document Type: Article

References (26)

1. Muruganandan S, Sinal C. Mice as clinically relevant models for the study of cytochrome P450-dependent metabolism. Clin Pharmacol Ther. 2008;83:818-28.
2. Nishimura T, Hu Y, Wu M, Pham E, Suemizu H, Elazar M, et al. Using chimeric mice with humanized livers to predict human drug metabolism and a drug-drug interaction. J Pharmacol Exp Ther. 2013;344:388-96.
3. Suemizu H, Hasegawa M, Kawai K, Taniguchi K, Monnai M, Wakui M, et al. Establishment of a humanized model of liver using NOD/Shi-scid IL2Rgnull mice. Biochem Biophys Res Commun. 2008;377:248-52.
4. Tateno C, Yoshizane Y, Saito N, Kataoka M, Utoh R, Yamasaki C, et al. Near completely humanized liver in mice shows human-type metabolic responses to drugs. Am J Pathol. 2004;165:901-12.
5. Hasegawa M, Kawai K, Mitsui T, Taniguchi K, Monnai M, Wakui M, et al. The reconstituted 'humanized liver'in TK-NOG mice is mature and functional. Biochem Biophys Res Commun. 2011;405:405-10.
6. Azuma H, Paulk N, Ranade A, Dorrell C, Al-Dhalimy M, Ellis E, et al. Robust expansion of human hepatocytes in Fah-/-/Rag2-/-/Il2rg-/- mice. Nat Biotechnol. 2007;25:903-10.
7. Rhim JA, Sandgren EP, Degen JL, Palmiter RD, Brinster RL. Replacement of diseased mouse liver by hepatic cell transplantation. Science. 1994;263:1149-52.
8. Haridass D, Yuan Q, Becker PD, Cantz T, Iken M, Rothe M, et al. Repopulation efficiencies of adult hepatocytes, fetal liver progenitor cells, and embryonic stem cell-derived hepatic cells in albumin-promoter-enhancer urokinase-type plasminogen activator mice. Am J Pathol. 2009;175:1483-92.
9. Sharma AD, Cantz T, Vogel A, Schambach A, Haridass D, Iken M, et al. Murine embryonic stem cell-derived hepatic progenitor cells engraft in recipient livers with limited capacity of liver tissue formation. Cell Transplant. 2008;17:313-23.
10. Peltz G. Can 'humanized'mice improve drug development in the 21st century? Trends Pharmacol Sci. 2013;34:255-60.
11. Zhu S, Rezvani M, Harbell J, Mattis AN, Wolfe AR, Benet LZ, et al. Mouse liver repopulation with hepatocytes generated from human fibroblasts. Nature. 2014;508:93-7.
12. Saito M, Iwawaki T, Taya C, Yonekawa H, Noda M, Inui Y, et al. Diphtheria toxin receptor-mediated conditional and targeted cell ablation in transgenic mice. Nat Biotechnol. 2001;19:746-50.
13. Ishii T, Yasuchika K, Machimoto T, Kamo N, Komori J, Konishi S, et al. Transplantation of embryonic stem cell-derived endodermal cells into mice with induced lethal liver damage. Stem Cells. 2007;25:3252-60.
14. Machimoto T, Yasuchika K, Komori J, Ishii T, Kamo N, Shimoda M, et al. Improvement of the survival rate by fetal liver cell transplantation in a mice lethal liver failure model. Transplantation. 2007;84:1233-9.
15. Taniguchi H, Zheng YW. Human hepatic stem cell, method for preparation of the same, method for induction of differentiation of the same, and method for utilization of the same. http://www.google.com/patents/US20110104126?hl=ja&cl=en.
16. Mouse Genome Informatics. Gene Expression Database. http://www.informatics.jax.org.
17. Takebe T, Sekine K, Enomura M, Koike H, Kimura M, Ogaeri T, et al. Vascularized and functional human liver from an iPSC-derived organ bud transplant. Nature. 2013;499:481-4.
18. Chen AA, Thomas DK, Ong LL, Schwartz RE, Golub TR, Bhatia SN. Humanized mice with ectopic artificial liver tissues. Proc Natl Acad Sci U S A. 2011;108:11842-7.
19. Si-Tayeb K, Noto FK, Nagaoka M, Li J, Battle MA, Duris C, et al. Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells. Hepatology. 2010;51:297-305.
20. Ishizaki T, Sasaki T, Suganuma T, Horai Y, Chiba K, Watanabe M, et al. Pharmacokinetics of ketoprofen following single oral, intramuscular and rectal doses and after repeated oral administration. Eur J Clin Pharmacol. 1980;18:407-14.
21. Yu A-M, Idle JR, Gonzalez FJ. Polymorphic cytochrome P450 2D6: humanized mouse model and endogenous substrates. Drug Metab Rev. 2004;36:243-77.
22. Strom SC, Davila J, Grompe M. Chimeric mice with humanized liver: tools for the study of drug metabolism, excretion, and toxicity. Methods Mol Biol. 2010;640:491-509.
23. Bateman TJ, Reddy VG, Kakuni M, Morikawa Y, Kumar S. Application of chimeric mice with humanized liver for study of human-specific drug metabolism. Drug Metab Dispos. 2014;42:1055-65.
24. Zhang D, Luo G, Ding X, Lu C. Preclinical experimental models of drug metabolism and disposition in drug discovery and development. Acta Pharmaceutica Sinica B. 2012;2:549-61.
25. Nowak G, Ericzon B, Nava S, Jaksch M, Westgren M, Sumitran-Holgersson S. Identification of expandable human hepatic progenitors which differentiate into mature hepatic cells in vivo. Gut. 2005;54:972-9.
26. Liu Y, Yang R, He Z, Gao W-Q. Generation of functional organs from stem cells. Cell Regeneration. 2013;2:1.