Development of murine cyp3a knockout chimeric mice with humanized liver

Drug Metabolism and Disposition

Volumn 43, Issue 8, 2015, Pages 1208-1217

  Kato, Kota ^a   Ohbuchi, Masato ^a   Hamamura, Satoko ^d   Ohshita, Hiroki ^d   Kazuki, Yasuhiro ^b   Oshimura, Mitsuo ^b   Sato, Koya ^a   Nakada, Naoyuki ^a   Kawamura, Akio ^a   Usui, Takashi ^a   Kamimura, Hidetaka ^c   Tateno, Chise ^d,e  

^a ASTELLAS PHARMA INC   (Japan)

^b TOTTORI UNIVERSITY   (Japan)

^c SEKISUI CHEMICAL CO LTD   (Japan)

^d PhoenixBio USA Corporation   (Japan)

^e HIROSHIMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; CYTOCHROME P450 2B10; CYTOCHROME P450 2C55; CYTOCHROME P450 3A; CYTOCHROME P450 3A11; GLUCURONOSYLTRANSFERASE 1A1; GLUCURONOSYLTRANSFERASE 1A9; GLUCURONOSYLTRANSFERASE 2B7; HUMAN ALBUMIN; MESSENGER RNA; MIDAZOLAM; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 1; SULFOTRANSFERASE; SULFOTRANSFERASE 1A1; SULFOTRANSFERASE 1E1; SULFOTRANSFERASE 2A1; TRIAZOLAM; UNCLASSIFIED DRUG; ALBUMINOID; CYP2B10 PROTEIN, MOUSE; CYP2C55 PROTEIN, MOUSE; CYP3A PROTEIN, MOUSE; GLUCURONOSYLTRANSFERASE; ISOENZYME; STEROID MONOOXYGENASE; UNSPECIFIC MONOOXYGENASE; UROKINASE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; INTESTINE; KNOCKOUT MOUSE; LIVER; LIVER MICROSOME; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; ANIMAL; BIOSYNTHESIS; CHIMERA; ENZYMOLOGY; GENETICS; HUMAN; LIVER CELL; METABOLISM; SCID MOUSE; TRANSGENIC MOUSE; TRANSPLANTATION;

MURINAE; MUS;

ALBUMINS; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CHIMERA; CYTOCHROME P-450 ENZYME SYSTEM; GLUCURONOSYLTRANSFERASE; HEPATOCYTES; HUMANS; INTESTINES; ISOENZYMES; LIVER; MICE; MICE, KNOCKOUT; MICE, SCID; MICE, TRANSGENIC; MICROSOMES, LIVER; MIDAZOLAM; RNA, MESSENGER; STEROID HYDROXYLASES; TRIAZOLAM; UROKINASE-TYPE PLASMINOGEN ACTIVATOR;

EID: 84940394133     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.115.063479     Document Type: Article

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