Quantitative relationship between rifampicin exposure and induction of Cyp3a11 in SXR humanized mice: Extrapolation to human CYP3A4 induction potential

Drug Metabolism Letters

Volumn 2, Issue 3, 2008, Pages 169-175

  Kim, Sean ^a   Pray, Devin ^a   Zheng, Ming ^a   Morgan, Daniel G ^a   Pizzano, Jennifer G ^a   Zoeckler, Mary E ^a   Chimalakonda, Anjaneya ^a   Sinz, Michael W ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

CYP induction; CYP3A11; CYP3A4; Drug drug interaction; Rifampicin; SXR humanized mouse

Indexed keywords

ALPRAZOLAM; CYTOCHROME P450 3A11; CYTOCHROME P450 3A4; MESSENGER RNA; MICROSOME ENZYME; PREGNANE X RECEPTOR; RIFAMPICIN; TRIAZOLAM;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG COMPETITION; DRUG DOSE COMPARISON; DRUG EXPOSURE; DRUG HALF LIFE; DRUG LIVER LEVEL; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME SUBSTRATE; GENE EXPRESSION; IN VIVO STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; PREDICTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; STRAIN DIFFERENCE;

ANIMALS; ANTIBIOTICS, ANTITUBERCULAR; CYTOCHROME P-450 CYP3A; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ENZYME INDUCTION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MICROSOMES, LIVER; MODELS, ANIMAL; RECEPTORS, STEROID; RIFAMPIN; RNA, MESSENGER; SPECIES SPECIFICITY; TRIAZOLAM;

MUS;

EID: 53749106271     PISSN: 18723128     EISSN: None     Source Type: Journal    
DOI: 10.2174/187231208785425809     Document Type: Article

References (28)

1. Lin, J. H. Pharm. Res., 2006, 23(6), 1089.
2. Smith, D. A. Eur. J. Pharm. Sci., 2000, 11(3), 185.
3. Lin, J. H.; Lu, A. Y. Clin. Pharmacokinet., 1990, 35(5), 361.
4. Kliewer, S. A. J. Nutr., 2003, 133(7. Suppl), 2444S.
5. Sinz, M.; Kim, S.; Zhu, Z.; Chen, T.; Anthony, M.; Dickinson, K.; Rodrigues, A. D. Curr. Drug Metab., 2006, 7(4), 375.
6. Luo, G.; Cunningham, M.; Kim, S.; Burn, T.; Lin, J.; Sinz, M.; Hamilton, G.; Rizzo, C.; Jolley, S.; Gilbert, D.; Downey, A.; Mudra, D.; Graham, R.; Carroll, K.; Xie, J.; Madan, A.; Parkinson, A.; Christ, D.; Selling, B.; LeCluyse, E.; Gan, L. S. Drug Metab. Dispos., 2002, 30(7), 795.
7. Vignati, L. A.; Bogni, A.; Grossi, P.; Monshouwer, M. Toxicology, 2004, 199(1), 23.
8. Stanley, L. A.; Horsburgh, B. C.; Ross, L; Scheer, N.; Wolf, C. R. Drug Metab. Rev., 2006, 38(3), 515.
9. Sinz, M. W.; Kim, S. Drug. Discov. Today: Technol., 2006, 3(1), 79.
10. Liddle, C.; Robertson, G. R. Pharmacogenomics, 2003, 4(2), 141.
11. Ripp, S. L.; Mills, J. B.; Fahmi, O. A.; Trevena, K. A.; Liras, J. L.; Maurer, T. S.; de Morais, S. M. Drug Metab. Dispos., 2006, 34(10), 1742.
12. Cantoni, L.; Rozio, M.; Mangolini, A.; Hauri, L.; Caccia, S. Toxicol. Sci., 2003, 75(1), 25.
13. Down, M. J.; Arkle, S.; Mills, J. J. Arch. Biochem. Biophys., 2007, 457(1), 105.
14. Gonzalez, F. J.; Yu, A. M. Annu. Rev. Pharmacol. Toxicol., 2006, 46, 41.
15. Ma, X.; Shah, Y.; Cheung, C.; Guo, G. L.; Feigenbaum, L.; Krausz, K. W.; Idle, J. R.; Gonzalez, F. J. Drug Metab. Dispos., 2007, 35(2), 194.
16. Xie, W.; Evans, R. M. Drug. Discov. Today, 2002, 7(9), 509.
17. Xie, W.; Barwick, J. L.; Downes, M.; Blumberg, B.; Simon, C. M.; Nelson, M. C.; Neuschwander-Tetri, B. A.; Brunt, E. M.; Guzelian, P. S.; Evans, R. M. Nature, 2000, 406(6794), 435.
18. Zhang, H.; Cui, D.; Wang, B.; Han, Y. H.; Balimane, P.; Yang, Z.; Sinz, M.; Rodrigues, A. D. Clin. Pharmacokinet., 2007, 46(2), 133.
19. Bolt, H. M. Drug. Metab. Rev., 2004, 36(3-4), 497.
20. Lemahieu, W. P.; Maes, B. D.; Vanrenterghem, Y. Transplant, Proc., 2005, 37(5), 2051.
21. Niemi, M.; Backman, J. T.; Fromm, M. F.; Neuvonen, P. J.; Kivisto, K. T. Clin. Pharmacokinet., 2003, 42(9), 819.
22. Worboys, P. D.; Carlile, D. J. Xenobiotica, 2001, 31(8-9), 539.
23. Pan, J.; Xiang, Q.; Ball, S.; Scatina, J.; Kao, J.; Hong, J. Y. Drug Metab. Dispos., 2003, 31(4), 392.
24. Fowler, B. A.; Lucier, G. W.; Hayes, A. W. In Principles and Methods of Toxicology, 2nd ed. Hayes, A. W., Ed. Raven Press, Ltd.: New York, 1989; pp 815-833.
25. Israili, Z. H.; Rogers, C. M.; El-Attar, H. J. Clin. Pharmacol., 1987, 27(1), 78.
26. Acocella, G. Clin. Pharmacokinet., 1978, 3(2), 108,
27. Perloff, M. D.; von Moltke, L. L.; Court, M. H.; Kotegawa, T.; Shader, R. I.; Greenblatt, D. J. J. Pharmacol. Exp. Ther., 2000, 292(2), 618.
28. Villikka, K.; Kivisto, K. T.; Backman, J. T.; Olkkola, K. T.; Neuvonen, P. J. Clin. Pharmacol. Ther., 1997, 61(1), 8.