Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo

Toxicological Sciences

Volumn 116, Issue 2, 2010, Pages 452-466

  Ross, Jillian ^a   Plummer, Simon M ^a   Rode, Anja ^b   Scheer, Nico ^b   Bower, Conrad C ^c   Vogel, Ortwin ^d   Henderson, Colin J ^c   Wolf, C Roland ^a   Elcombe, Clifford R ^a  

^a CXR Biosciences Ltd   (United Kingdom)

^b TaconicArtemis   (Germany)

^c UNIVERSITY OF DUNDEE   (United Kingdom)

^d TPC Toxicologic Pathology Consultancy   (Germany)

Author keywords

"Humanized" mice; Chlordane; Constitutive androstane receptor; Nongenotoxic carcinogenesis; PB; PXR

Indexed keywords

CHLORDANE; CONSTITUTIVE ANDROSTANE RECEPTOR; CYP2B10; CYTOCHROME; CYTOCHROME P450 3A11; PHENOBARBITAL; PREGNANE X RECEPTOR; UNCLASSIFIED DRUG; CELL RECEPTOR; CYP2B10 PROTEIN, MOUSE; CYP3A11 PROTEIN, MOUSE; CYTOCHROME P450 3A; MEMBRANE PROTEIN; STEROID MONOOXYGENASE; STEROID RECEPTOR; UNSPECIFIC MONOOXYGENASE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; C57BL 6 MOUSE; CELL CYCLE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; HEPATOMEGALY; HUMAN; IN VIVO STUDY; KNOCKOUT MOUSE; LIVER CARCINOGENESIS; LIVER CELL; LIVER WEIGHT; MOUSE; NONHUMAN; WILD TYPE; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CHEMICALLY INDUCED; DRUG EFFECTS; EXPERIMENTAL LIVER NEOPLASM; HYPERPLASIA; HYPERTROPHY; LIVER; METABOLISM; PATHOLOGY; PHYSIOLOGY; SPECIES DIFFERENCE; TOXICITY;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CELL PROLIFERATION; CHLORDAN; CYTOCHROME P-450 CYP3A; HUMANS; HYPERPLASIA; HYPERTROPHY; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; PHENOBARBITAL; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; SPECIES SPECIFICITY; STEROID HYDROXYLASES;

EID: 77955084537     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfq118     Document Type: Article

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