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Volumn 7, Issue APR, 2016, Pages

Inflammation meets metabolic disease: Gut feeling mediated by GLP-1

Author keywords

Diabetes mellitus; Enteroendocrine cells; ER stress; Glucagon like peptide 1; Incretins; Inflammation; Inflammatory bowel disease; Microbiota

Indexed keywords

CHOLECYSTOKININ; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 40; GLUCAGON LIKE PEPTIDE 1; INCRETIN; INTERLEUKIN 6; REACTIVE OXYGEN METABOLITE; SHORT CHAIN FATTY ACID; SODIUM GLUCOSE COTRANSPORTER; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR;

EID: 84966709097     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2016.00154     Document Type: Review
Times cited : (103)

References (209)
  • 1
    • 79955694765 scopus 로고    scopus 로고
    • Obesity and socioeconomic status in children and adolescents: United States, 2005-2008
    • Ogden CL, Lamb MM, Carroll MD, Flegal KM. Obesity and socioeconomic status in children and adolescents: United States, 2005-2008. NCHS Data Brief (2010) (51):1-8
    • (2010) NCHS Data Brief , Issue.51 , pp. 1-8
    • Ogden, C.L.1    Lamb, M.M.2    Carroll, M.D.3    Flegal, K.M.4
  • 2
    • 33846422032 scopus 로고    scopus 로고
    • Obesity and diabetes in the developing world-a growing challenge
    • Hossain P, Kawar B, El Nahas M. Obesity and diabetes in the developing world-a growing challenge. N Engl J Med (2007) 356(3):213-5. doi:10.1056/NEJMp068177
    • (2007) N Engl J Med , vol.356 , Issue.3 , pp. 213-215
    • Hossain, P.1    Kawar, B.2    El Nahas, M.3
  • 3
    • 33745775434 scopus 로고    scopus 로고
    • Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis
    • Sartor RB. Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis. Nat Clin Pract Gastroenterol Hepatol (2006) 3(7):390-407. doi:10.1038/ncpgasthep0528
    • (2006) Nat Clin Pract Gastroenterol Hepatol , vol.3 , Issue.7 , pp. 390-407
    • Sartor, R.B.1
  • 4
    • 15744400763 scopus 로고    scopus 로고
    • Distribution of major health risks: findings from the Global Burden of Disease study
    • Rodgers A, Ezzati M, Vander Hoorn S, Lopez AD, Lin RB, Murray CJ, et al. Distribution of major health risks: findings from the Global Burden of Disease study. PLoS Med (2004) 1(1):e27. doi:10.1371/journal.pmed.0010027
    • (2004) PLoS Med , vol.1 , Issue.1
    • Rodgers, A.1    Ezzati, M.2    Vander Hoorn, S.3    Lopez, A.D.4    Lin, R.B.5    Murray, C.J.6
  • 5
    • 33845866857 scopus 로고    scopus 로고
    • Inflammation and metabolic disorders
    • Hotamisligil GS. Inflammation and metabolic disorders. Nature (2006) 444(7121):860-7. doi:10.1038/nature05485
    • (2006) Nature , vol.444 , Issue.7121 , pp. 860-867
    • Hotamisligil, G.S.1
  • 6
    • 84946753563 scopus 로고    scopus 로고
    • The incretin effect in critically ill patients: a case-control study
    • Nielsen ST, Janum S, Krogh-Madsen R, Solomon TP, Møller K. The incretin effect in critically ill patients: a case-control study. Crit Care (2015) 19(1):402. doi:10.1186/s13054-015-1118-z
    • (2015) Crit Care , vol.19 , Issue.1 , pp. 402
    • Nielsen, S.T.1    Janum, S.2    Krogh-Madsen, R.3    Solomon, T.P.4    Møller, K.5
  • 7
    • 84928244016 scopus 로고    scopus 로고
    • Gliptin and GLP-1 analog treatment improves survival and vascular inflammation/dysfunction in animals with lipopolysaccharide-induced endotoxemia
    • Steven S, Hausding M, Kröller-Schön S, Mader M, Mikhed Y, Stamm P, et al. Gliptin and GLP-1 analog treatment improves survival and vascular inflammation/dysfunction in animals with lipopolysaccharide-induced endotoxemia. Basic Res Cardiol (2015) 110(2):6. doi:10.1007/s00395-015-0465-x
    • (2015) Basic Res Cardiol , vol.110 , Issue.2 , pp. 6
    • Steven, S.1    Hausding, M.2    Kröller-Schön, S.3    Mader, M.4    Mikhed, Y.5    Stamm, P.6
  • 8
    • 80052546811 scopus 로고    scopus 로고
    • Inflammation and cellular stress: a mechanistic link between immune-mediated and metabolically driven pathologies
    • Rath E, Haller D. Inflammation and cellular stress: a mechanistic link between immune-mediated and metabolically driven pathologies. Eur J Nutr (2011) 50(4):219-33. doi:10.1007/s00394-011-0197-0
    • (2011) Eur J Nutr , vol.50 , Issue.4 , pp. 219-233
    • Rath, E.1    Haller, D.2
  • 9
    • 84925873107 scopus 로고    scopus 로고
    • Immune regulation of metabolic homeostasis in health and disease
    • Brestoff JR, Artis D. Immune regulation of metabolic homeostasis in health and disease. Cell (2015) 161(1):146-60. doi:10.1016/j.cell.2015.02.022
    • (2015) Cell , vol.161 , Issue.1 , pp. 146-160
    • Brestoff, J.R.1    Artis, D.2
  • 10
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance
    • Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science (1993) 259(5091):87-91. doi:10.1126/science.7678183
    • (1993) Science , vol.259 , Issue.5091 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 11
    • 84922017739 scopus 로고    scopus 로고
    • Intestinal microbiota in metabolic diseases: from bacterial community structure and functions to species of pathophysiological relevance
    • Clavel T, Desmarchelier C, Haller D, Gérard P, Rohn S, Lepage P, et al. Intestinal microbiota in metabolic diseases: from bacterial community structure and functions to species of pathophysiological relevance. Gut Microbes (2014) 5(4):544-51. doi:10.4161/gmic.29331
    • (2014) Gut Microbes , vol.5 , Issue.4 , pp. 544-551
    • Clavel, T.1    Desmarchelier, C.2    Haller, D.3    Gérard, P.4    Rohn, S.5    Lepage, P.6
  • 12
    • 34548612724 scopus 로고    scopus 로고
    • Bacteria- and host-derived mechanisms to control intestinal epithelial cell homeostasis: implications for chronic inflammation
    • Clavel T, Haller D. Bacteria- and host-derived mechanisms to control intestinal epithelial cell homeostasis: implications for chronic inflammation. Inflamm Bowel Dis (2007) 13(9):1153-64. doi:10.1002/ibd.20174
    • (2007) Inflamm Bowel Dis , vol.13 , Issue.9 , pp. 1153-1164
    • Clavel, T.1    Haller, D.2
  • 13
    • 84901506886 scopus 로고    scopus 로고
    • Surface area of the digestive tract-revisited
    • Helander HF, Fandriks L. Surface area of the digestive tract-revisited. Scand J Gastroenterol (2014) 49(6):681-9. doi:10.3109/00365521.2014.898326
    • (2014) Scand J Gastroenterol , vol.49 , Issue.6 , pp. 681-689
    • Helander, H.F.1    Fandriks, L.2
  • 14
    • 84938812082 scopus 로고    scopus 로고
    • The intestinal immunoendocrine axis: novel cross-talk between enteroendocrine cells and the immune system during infection and inflammatory disease
    • Worthington JJ. The intestinal immunoendocrine axis: novel cross-talk between enteroendocrine cells and the immune system during infection and inflammatory disease. Biochem Soc Trans (2015) 43(4):727-33. doi:10.1042/BST20150090
    • (2015) Biochem Soc Trans , vol.43 , Issue.4 , pp. 727-733
    • Worthington, J.J.1
  • 15
    • 84942781740 scopus 로고    scopus 로고
    • Intestinal nutrient sensing and blood glucose control
    • Zietek T, Daniel H. Intestinal nutrient sensing and blood glucose control. Curr Opin Clin Nutr Metab Care (2015) 18(4):381-8. doi:10.1097/MCO.0000000000000187
    • (2015) Curr Opin Clin Nutr Metab Care , vol.18 , Issue.4 , pp. 381-388
    • Zietek, T.1    Daniel, H.2
  • 16
    • 84862743498 scopus 로고    scopus 로고
    • Overlap of endocrine hormone expression in the mouse intestine revealed by transcriptional profiling and flow cytometry
    • Habib AM, Richards P, Cairns LS, Rogers GJ, Bannon CA, Parker HE, et al. Overlap of endocrine hormone expression in the mouse intestine revealed by transcriptional profiling and flow cytometry. Endocrinology (2012) 153(7):3054-65. doi:10.1210/en.2011-2170
    • (2012) Endocrinology , vol.153 , Issue.7 , pp. 3054-3065
    • Habib, A.M.1    Richards, P.2    Cairns, L.S.3    Rogers, G.J.4    Bannon, C.A.5    Parker, H.E.6
  • 17
    • 84870225450 scopus 로고    scopus 로고
    • A major lineage of enteroendocrine cells coexpress CCK, secretin, GIP, GLP-1, PYY, and neurotensin but not somatostatin
    • Egerod KL, Engelstoft MS, Grunddal KV, Nøhr MK, Secher A, Sakata I, et al. A major lineage of enteroendocrine cells coexpress CCK, secretin, GIP, GLP-1, PYY, and neurotensin but not somatostatin. Endocrinology (2012) 153(12):5782-95. doi:10.1210/en.2012-1595
    • (2012) Endocrinology , vol.153 , Issue.12 , pp. 5782-5795
    • Egerod, K.L.1    Engelstoft, M.S.2    Grunddal, K.V.3    Nøhr, M.K.4    Secher, A.5    Sakata, I.6
  • 18
    • 84907059371 scopus 로고    scopus 로고
    • Duodenal CCK cells from male mice express multiple hormones including ghrelin
    • Sykaras AG, Demenis C, Cheng L, Pisitkun T, Mclaughlin JT, Fenton RA, et al. Duodenal CCK cells from male mice express multiple hormones including ghrelin. Endocrinology (2014) 155(9):3339-51. doi:10.1210/en.2013-2165
    • (2014) Endocrinology , vol.155 , Issue.9 , pp. 3339-3351
    • Sykaras, A.G.1    Demenis, C.2    Cheng, L.3    Pisitkun, T.4    Mclaughlin, J.T.5    Fenton, R.A.6
  • 19
    • 84958620086 scopus 로고    scopus 로고
    • Enteroendocrine cells: chemosensors in the intestinal epithelium
    • Gribble FM, Reimann F. Enteroendocrine cells: chemosensors in the intestinal epithelium. Annu Rev Physiol (2016) 78:277-99. doi:10.1146/annurev-physiol-021115-105439
    • (2016) Annu Rev Physiol , vol.78 , pp. 277-299
    • Gribble, F.M.1    Reimann, F.2
  • 20
    • 79952510102 scopus 로고    scopus 로고
    • Luminal amino acid-sensing cells in gastric mucosa
    • Nakamura E, Hasumura M, Uneyama H, Torii K. Luminal amino acid-sensing cells in gastric mucosa. Digestion (2011) 83(Suppl 1):13-8. doi:10.1159/000323399
    • (2011) Digestion , vol.83 , pp. 13-18
    • Nakamura, E.1    Hasumura, M.2    Uneyama, H.3    Torii, K.4
  • 21
    • 34347389492 scopus 로고    scopus 로고
    • GPR93 activation by protein hydrolysate induces CCK transcription and secretion in STC-1 cells
    • Choi S, Lee M, Shiu AL, Yo SJ, Halldén G, Aponte GW. GPR93 activation by protein hydrolysate induces CCK transcription and secretion in STC-1 cells. Am J Physiol Gastrointest Liver Physiol (2007) 292(5):G1366-75. doi:10.1152/ajpgi.00516.2006
    • (2007) Am J Physiol Gastrointest Liver Physiol , vol.292 , Issue.5 , pp. G1366-G1375
    • Choi, S.1    Lee, M.2    Shiu, A.L.3    Yo, S.J.4    Halldén, G.5    Aponte, G.W.6
  • 22
    • 84874040640 scopus 로고    scopus 로고
    • The G protein-coupled receptor family C group 6 subtype A (GPRC6A) receptor is involved in amino acid-induced glucagon-like peptide-1 secretion from GLUTag cells
    • Oya M, Kitaguchi T, Pais R, Reimann F, Gribble F, Tsuboi T. The G protein-coupled receptor family C group 6 subtype A (GPRC6A) receptor is involved in amino acid-induced glucagon-like peptide-1 secretion from GLUTag cells. J Biol Chem (2013) 288(7):4513-21. doi:10.1074/jbc.M112.402677
    • (2013) J Biol Chem , vol.288 , Issue.7 , pp. 4513-4521
    • Oya, M.1    Kitaguchi, T.2    Pais, R.3    Reimann, F.4    Gribble, F.5    Tsuboi, T.6
  • 23
    • 80054787845 scopus 로고    scopus 로고
    • Umami receptor activation increases duodenal bicarbonate secretion via glucagon-like peptide-2 release in rats
    • Wang JH, Inoue T, Higashiyama M, Guth PH, Engel E, Kaunitz JD, et al. Umami receptor activation increases duodenal bicarbonate secretion via glucagon-like peptide-2 release in rats. J Pharmacol Exp Ther (2011) 339(2):464-73. doi:10.1124/jpet.111.184788
    • (2011) J Pharmacol Exp Ther , vol.339 , Issue.2 , pp. 464-473
    • Wang, J.H.1    Inoue, T.2    Higashiyama, M.3    Guth, P.H.4    Engel, E.5    Kaunitz, J.D.6
  • 24
    • 35448995622 scopus 로고    scopus 로고
    • T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1
    • Margolskee RF, Dyer J, Kokrashvili Z, Salmon KS, Ilegems E, Daly K, et al. T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1. Proc Natl Acad Sci U S A (2007) 104(38):15075-80. doi:10.1073/pnas.0706678104
    • (2007) Proc Natl Acad Sci U S A , vol.104 , Issue.38 , pp. 15075-15080
    • Margolskee, R.F.1    Dyer, J.2    Kokrashvili, Z.3    Salmon, K.S.4    Ilegems, E.5    Daly, K.6
  • 25
    • 84994632130 scopus 로고    scopus 로고
    • Lipid-rich diet enhances L-cell density in obese subjects and in mice through improved L-cell differentiation
    • Aranias T, Grosfeld A, Poitou C, Omar AA, Le Gall M, Miquel S, et al. Lipid-rich diet enhances L-cell density in obese subjects and in mice through improved L-cell differentiation. J Nutr Sci (2015) 4:e22. doi:10.1017/jns.2015.11
    • (2015) J Nutr Sci , vol.4
    • Aranias, T.1    Grosfeld, A.2    Poitou, C.3    Omar, A.A.4    Le Gall, M.5    Miquel, S.6
  • 26
    • 80053459477 scopus 로고    scopus 로고
    • Gustatory and extragustatory functions of mammalian taste receptors
    • Behrens M, Meyerhof W. Gustatory and extragustatory functions of mammalian taste receptors. Physiol Behav (2011) 105(1):4-13. doi:10.1016/j.physbeh.2011.02.010
    • (2011) Physiol Behav , vol.105 , Issue.1 , pp. 4-13
    • Behrens, M.1    Meyerhof, W.2
  • 27
    • 55849136194 scopus 로고    scopus 로고
    • SREBP-2 regulates gut peptide secretion through intestinal bitter taste receptor signaling in mice
    • Jeon TI, Zhu B, Larson JL, Osborne TF. SREBP-2 regulates gut peptide secretion through intestinal bitter taste receptor signaling in mice. J Clin Invest (2008) 118(11):3693-700. doi:10.1172/JCI36461
    • (2008) J Clin Invest , vol.118 , Issue.11 , pp. 3693-3700
    • Jeon, T.I.1    Zhu, B.2    Larson, J.L.3    Osborne, T.F.4
  • 28
    • 84455160918 scopus 로고    scopus 로고
    • Effects of different sweet preloads on incretin hormone secretion, gastric emptying, and postprandial glycemia in healthy humans
    • Wu T, Zhao BR, Bound MJ, Checklin HL, Bellon M, Little TJ, et al. Effects of different sweet preloads on incretin hormone secretion, gastric emptying, and postprandial glycemia in healthy humans. Am J Clin Nutr (2012) 95(1):78-83. doi:10.3945/ajcn.111.021543
    • (2012) Am J Clin Nutr , vol.95 , Issue.1 , pp. 78-83
    • Wu, T.1    Zhao, B.R.2    Bound, M.J.3    Checklin, H.L.4    Bellon, M.5    Little, T.J.6
  • 29
    • 79953773104 scopus 로고    scopus 로고
    • Effects of oral ingestion of sucralose on gut hormone response and appetite in healthy normal-weight subjects
    • Ford HE, Peters V, Martin NM, Sleeth ML, Ghatei MA, Frost GS, et al. Effects of oral ingestion of sucralose on gut hormone response and appetite in healthy normal-weight subjects. Eur J Clin Nutr (2011) 65(4):508-13. doi:10.1038/ejcn.2010.291
    • (2011) Eur J Clin Nutr , vol.65 , Issue.4 , pp. 508-513
    • Ford, H.E.1    Peters, V.2    Martin, N.M.3    Sleeth, M.L.4    Ghatei, M.A.5    Frost, G.S.6
  • 30
    • 79955997980 scopus 로고    scopus 로고
    • Effects of carbohydrate sugars and artificial sweeteners on appetite and the secretion of gastrointestinal satiety peptides
    • Steinert RE, Frey F, Töpfer A, Drewe J, Beglinger C. Effects of carbohydrate sugars and artificial sweeteners on appetite and the secretion of gastrointestinal satiety peptides. Br J Nutr (2011) 105(9):1320-8. doi:10.1017/S000711451000512X
    • (2011) Br J Nutr , vol.105 , Issue.9 , pp. 1320-1328
    • Steinert, R.E.1    Frey, F.2    Töpfer, A.3    Drewe, J.4    Beglinger, C.5
  • 31
    • 84907197891 scopus 로고    scopus 로고
    • Diet-induced regulation of bitter taste receptor subtypes in the mouse gastrointestinal tract
    • Vegezzi G, Anselmi L, Huynh J, Barocelli E, Rozengurt E, Raybould H, et al. Diet-induced regulation of bitter taste receptor subtypes in the mouse gastrointestinal tract. PLoS One (2014) 9(9):e107732. doi:10.1371/journal.pone.0107732
    • (2014) PLoS One , vol.9 , Issue.9
    • Vegezzi, G.1    Anselmi, L.2    Huynh, J.3    Barocelli, E.4    Rozengurt, E.5    Raybould, H.6
  • 32
    • 84959449511 scopus 로고    scopus 로고
    • Expression of the bitter taste receptor, T2R38, in enteroendocrine cells of the colonic mucosa of overweight/obese vs. lean subjects
    • Latorre R, Huynh J, Mazzoni M, Gupta A, Bonora E, Clavenzani P, et al. Expression of the bitter taste receptor, T2R38, in enteroendocrine cells of the colonic mucosa of overweight/obese vs. lean subjects. PLoS One (2016) 11(2):e0147468. doi:10.1371/journal.pone.0147468
    • (2016) PLoS One , vol.11 , Issue.2
    • Latorre, R.1    Huynh, J.2    Mazzoni, M.3    Gupta, A.4    Bonora, E.5    Clavenzani, P.6
  • 33
    • 84920647529 scopus 로고    scopus 로고
    • Taste receptors in innate immunity
    • Lee RJ, Cohen NA. Taste receptors in innate immunity. Cell Mol Life Sci (2015) 72(2):217-36. doi:10.1007/s00018-014-1736-7
    • (2015) Cell Mol Life Sci , vol.72 , Issue.2 , pp. 217-236
    • Lee, R.J.1    Cohen, N.A.2
  • 34
    • 84893055427 scopus 로고    scopus 로고
    • Lipopolysaccharides-mediated increase in glucose-stimulated insulin secretion: involvement of the GLP-1 pathway
    • Nguyen AT, Mandard S, Dray C, Deckert V, Valet P, Besnard P, et al. Lipopolysaccharides-mediated increase in glucose-stimulated insulin secretion: involvement of the GLP-1 pathway. Diabetes (2014) 63(2):471-82. doi:10.2337/db13-0903
    • (2014) Diabetes , vol.63 , Issue.2 , pp. 471-482
    • Nguyen, A.T.1    Mandard, S.2    Dray, C.3    Deckert, V.4    Valet, P.5    Besnard, P.6
  • 35
    • 84887889962 scopus 로고    scopus 로고
    • Microbial modulation of energy availability in the colon regulates intestinal transit
    • Wichmann A, Allahyar A, Greiner TU, Plovier H, Lundén Gö, Larsson T, et al. Microbial modulation of energy availability in the colon regulates intestinal transit. Cell Host Microbe (2013) 14(5):582-90. doi:10.1016/j.chom.2013.09.012
    • (2013) Cell Host Microbe , vol.14 , Issue.5 , pp. 582-590
    • Wichmann, A.1    Allahyar, A.2    Greiner, T.U.3    Plovier, H.4    Lundén, Gö.5    Larsson, T.6
  • 36
    • 84912137874 scopus 로고    scopus 로고
    • Bacterial metabolite indole modulates incretin secretion from intestinal enteroendocrine L cells
    • Chimerel C, Emery E, Summers DK, Keyser U, Gribble FM, Reimann F. Bacterial metabolite indole modulates incretin secretion from intestinal enteroendocrine L cells. Cell Rep (2014) 9(4):1202-8. doi:10.1016/j.celrep.2014.10.032
    • (2014) Cell Rep , vol.9 , Issue.4 , pp. 1202-1208
    • Chimerel, C.1    Emery, E.2    Summers, D.K.3    Keyser, U.4    Gribble, F.M.5    Reimann, F.6
  • 37
    • 84880907693 scopus 로고    scopus 로고
    • The bile acid membrane receptor TGR5: a novel pharmacological target in metabolic, inflammatory and neoplastic disorders
    • Stepanov V, Stankov K, Mikov M. The bile acid membrane receptor TGR5: a novel pharmacological target in metabolic, inflammatory and neoplastic disorders. J Recept Signal Transduct Res (2013) 33(4):213-23. doi:10.3109/10799893.2013.802805
    • (2013) J Recept Signal Transduct Res , vol.33 , Issue.4 , pp. 213-223
    • Stepanov, V.1    Stankov, K.2    Mikov, M.3
  • 38
    • 33947667036 scopus 로고    scopus 로고
    • Activation of enteroendocrine cells via TLRs induces hormone, chemokine, and defensin secretion
    • Palazzo M, Balsari A, Rossini A, Selleri S, Calcaterra C, Gariboldi S, et al. Activation of enteroendocrine cells via TLRs induces hormone, chemokine, and defensin secretion. J Immunol (2007) 178(7):4296-303. doi:10.4049/jimmunol.178.7.4296
    • (2007) J Immunol , vol.178 , Issue.7 , pp. 4296-4303
    • Palazzo, M.1    Balsari, A.2    Rossini, A.3    Selleri, S.4    Calcaterra, C.5    Gariboldi, S.6
  • 39
    • 48249099626 scopus 로고    scopus 로고
    • Induction of pro-inflammatory programs in enteroendocrine cells by the Toll-like receptor agonists flagellin and bacterial LPS
    • Selleri S, Palazzo M, Deola S, Wang E, Balsari A, Marincola FM, et al. Induction of pro-inflammatory programs in enteroendocrine cells by the Toll-like receptor agonists flagellin and bacterial LPS. Int Immunol (2008) 20(8):961-70. doi:10.1093/intimm/dxn055
    • (2008) Int Immunol , vol.20 , Issue.8 , pp. 961-970
    • Selleri, S.1    Palazzo, M.2    Deola, S.3    Wang, E.4    Balsari, A.5    Marincola, F.M.6
  • 41
    • 84868089442 scopus 로고    scopus 로고
    • Cellular bases for interactions between immunocytes and enteroendocrine cells in the intestinal mucosal barrier of rhesus macaques
    • Zhang WJ, Duan JZ, Lei N, Xing H, Shao Y, Yang GB. Cellular bases for interactions between immunocytes and enteroendocrine cells in the intestinal mucosal barrier of rhesus macaques. Cell Tissue Res (2012) 350(1):135-41. doi:10.1007/s00441-012-1464-y
    • (2012) Cell Tissue Res , vol.350 , Issue.1 , pp. 135-141
    • Zhang, W.J.1    Duan, J.Z.2    Lei, N.3    Xing, H.4    Shao, Y.5    Yang, G.B.6
  • 43
    • 84857349948 scopus 로고    scopus 로고
    • The role and pathophysiological relevance of membrane transporter PepT1 in intestinal inflammation and inflammatory bowel disease
    • Ingersoll SA, Ayyadurai S, Charania MA, Laroui H, Yan Y, Merlin D. The role and pathophysiological relevance of membrane transporter PepT1 in intestinal inflammation and inflammatory bowel disease. Am J Physiol Gastrointest Liver Physiol (2012) 302(5):G484-92. doi:10.1152/ajpgi.00477.2011
    • (2012) Am J Physiol Gastrointest Liver Physiol , vol.302 , Issue.5 , pp. G484-G492
    • Ingersoll, S.A.1    Ayyadurai, S.2    Charania, M.A.3    Laroui, H.4    Yan, Y.5    Merlin, D.6
  • 44
    • 64649096522 scopus 로고    scopus 로고
    • Targeted disruption of peptide transporter Pept1 gene in mice significantly reduces dipeptide absorption in intestine
    • Hu Y, Smith DE, Ma K, Jappar D, Thomas W, Hillgren KM. Targeted disruption of peptide transporter Pept1 gene in mice significantly reduces dipeptide absorption in intestine. Mol Pharm (2008) 5(6):1122-30. doi:10.1021/mp8001655
    • (2008) Mol Pharm , vol.5 , Issue.6 , pp. 1122-1130
    • Hu, Y.1    Smith, D.E.2    Ma, K.3    Jappar, D.4    Thomas, W.5    Hillgren, K.M.6
  • 45
    • 84898759705 scopus 로고    scopus 로고
    • Colonic expression of the peptide transporter PEPT1 is downregulated during intestinal inflammation and is not required for NOD2-dependent immune activation
    • Wuensch T, Ullrich S, Schulz S, Chamaillard M, Schaltenberg N, Rath E, et al. Colonic expression of the peptide transporter PEPT1 is downregulated during intestinal inflammation and is not required for NOD2-dependent immune activation. Inflamm Bowel Dis (2014) 20(4):671-84. doi:10.1097/01.MIB.0000443336.71488.08
    • (2014) Inflamm Bowel Dis , vol.20 , Issue.4 , pp. 671-684
    • Wuensch, T.1    Ullrich, S.2    Schulz, S.3    Chamaillard, M.4    Schaltenberg, N.5    Rath, E.6
  • 47
    • 81255157471 scopus 로고    scopus 로고
    • Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells
    • Ellingsgaard H, Hauselmann I, Schuler B, Habib AM, Baggio LL, Meier DT, et al. Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells. Nat Med (2011) 17(11):1481-9. doi:10.1038/nm.2513
    • (2011) Nat Med , vol.17 , Issue.11 , pp. 1481-1489
    • Ellingsgaard, H.1    Hauselmann, I.2    Schuler, B.3    Habib, A.M.4    Baggio, L.L.5    Meier, D.T.6
  • 48
    • 59649088932 scopus 로고    scopus 로고
    • Insulin regulates glucagon-like peptide-1 secretion from the enteroendocrine L cell
    • Lim GE, Huang GJ, Flora N, LeRoith D, Rhodes CJ, Brubaker PL. Insulin regulates glucagon-like peptide-1 secretion from the enteroendocrine L cell. Endocrinology (2009) 150(2):580-91. doi:10.1210/en.2008-0726
    • (2009) Endocrinology , vol.150 , Issue.2 , pp. 580-591
    • Lim, G.E.1    Huang, G.J.2    Flora, N.3    LeRoith, D.4    Rhodes, C.J.5    Brubaker, P.L.6
  • 49
    • 0030013475 scopus 로고    scopus 로고
    • Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor
    • Bullock BP, Heller RS, Habener JF. Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor. Endocrinology (1996) 137(7):2968-78. doi:10.1210/endo.137.7.8770921
    • (1996) Endocrinology , vol.137 , Issue.7 , pp. 2968-2978
    • Bullock, B.P.1    Heller, R.S.2    Habener, J.F.3
  • 50
    • 84962086818 scopus 로고    scopus 로고
    • GLP-1R agonists modulate enteric immune responses through the intestinal intraepithelial lymphocyte GLP-1R
    • Yusta B, Baggio LL, Koehler J, Holland D, Cao X, Pinnell LJ, et al. GLP-1R agonists modulate enteric immune responses through the intestinal intraepithelial lymphocyte GLP-1R. Diabetes (2015) 64(7):2537-49. doi:10.2337/db14-1577
    • (2015) Diabetes , vol.64 , Issue.7 , pp. 2537-2549
    • Yusta, B.1    Baggio, L.L.2    Koehler, J.3    Holland, D.4    Cao, X.5    Pinnell, L.J.6
  • 51
    • 26844436564 scopus 로고    scopus 로고
    • Nutritional stimulation of cholecystokinin receptors inhibits inflammation via the vagus nerve
    • Luyer MD, Greve JW, Hadfoune M, Jacobs JA, Dejong CH, Buurman WA. Nutritional stimulation of cholecystokinin receptors inhibits inflammation via the vagus nerve. J Exp Med (2005) 202(8):1023-9. doi:10.1084/jem.20042397
    • (2005) J Exp Med , vol.202 , Issue.8 , pp. 1023-1029
    • Luyer, M.D.1    Greve, J.W.2    Hadfoune, M.3    Jacobs, J.A.4    Dejong, C.H.5    Buurman, W.A.6
  • 52
    • 0034668106 scopus 로고    scopus 로고
    • Altered enteroendocrine cell expression in T cell receptor alpha chain knock-out mice
    • Rubin DC, Zhang H, Qian P, Lorenz RG, Hutton K, Peters MG. Altered enteroendocrine cell expression in T cell receptor alpha chain knock-out mice. Microsc Res Tech (2000) 51(2):112-20. doi:10.1002/1097-0029(20001015)51:2<112::AID-JEMT2>3.0.CO;2-D
    • (2000) Microsc Res Tech , vol.51 , Issue.2 , pp. 112-120
    • Rubin, D.C.1    Zhang, H.2    Qian, P.3    Lorenz, R.G.4    Hutton, K.5    Peters, M.G.6
  • 53
    • 33644864860 scopus 로고    scopus 로고
    • Consequences of Citrobacter rodentium infection on enteroendocrine cells and the enteric nervous system in the mouse colon
    • O'Hara JR, Skinn AC, MacNaughton WK, Sherman PM, Sharkey KA. Consequences of Citrobacter rodentium infection on enteroendocrine cells and the enteric nervous system in the mouse colon. Cell Microbiol (2006) 8(4):646-60. doi:10.1111/j.1462-5822.2005.00657.x
    • (2006) Cell Microbiol , vol.8 , Issue.4 , pp. 646-660
    • O'Hara, J.R.1    Skinn, A.C.2    MacNaughton, W.K.3    Sherman, P.M.4    Sharkey, K.A.5
  • 54
    • 77949268923 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor signalling selectively regulates murine lymphocyte proliferation and maintenance of peripheral regulatory T cells
    • Hadjiyanni I, Siminovitch KA, Danska JS, Drucker DJ. Glucagon-like peptide-1 receptor signalling selectively regulates murine lymphocyte proliferation and maintenance of peripheral regulatory T cells. Diabetologia (2010) 53(4):730-40. doi:10.1007/s00125-009-1643-x
    • (2010) Diabetologia , vol.53 , Issue.4 , pp. 730-740
    • Hadjiyanni, I.1    Siminovitch, K.A.2    Danska, J.S.3    Drucker, D.J.4
  • 55
    • 0027201145 scopus 로고
    • Direct association of adenosine deaminase with a T cell activation antigen, CD26
    • Kameoka J, Tanaka T, Nojima Y, Schlossman SF, Morimoto C. Direct association of adenosine deaminase with a T cell activation antigen, CD26. Science (1993) 261(5120):466-9. doi:10.1126/science.8101391
    • (1993) Science , vol.261 , Issue.5120 , pp. 466-469
    • Kameoka, J.1    Tanaka, T.2    Nojima, Y.3    Schlossman, S.F.4    Morimoto, C.5
  • 56
    • 0031908130 scopus 로고    scopus 로고
    • The structure and function of CD26 in the T-cell immune response
    • Morimoto C, Schlossman SF. The structure and function of CD26 in the T-cell immune response. Immunol Rev (1998) 161:55-70. doi:10.1111/j.1600-065X.1998.tb01571.x
    • (1998) Immunol Rev , vol.161 , pp. 55-70
    • Morimoto, C.1    Schlossman, S.F.2
  • 57
    • 84892721397 scopus 로고    scopus 로고
    • Insulin inhibits IL-10-mediated regulatory T cell function: implications for obesity
    • Han JM, Patterson SJ, Speck M, Ehses JA, Levings MK. Insulin inhibits IL-10-mediated regulatory T cell function: implications for obesity. J Immunol (2014) 192(2):623-9. doi:10.4049/jimmunol.1302181
    • (2014) J Immunol , vol.192 , Issue.2 , pp. 623-629
    • Han, J.M.1    Patterson, S.J.2    Speck, M.3    Ehses, J.A.4    Levings, M.K.5
  • 58
    • 77952028081 scopus 로고    scopus 로고
    • Elevated circulating levels of an incretin hormone, glucagon-like peptide-1, are associated with metabolic components in high-risk patients with cardiovascular disease
    • Yamaoka-Tojo M, Tojo T, Takahira N, Matsunaga A, Aoyama N, Masuda T, et al. Elevated circulating levels of an incretin hormone, glucagon-like peptide-1, are associated with metabolic components in high-risk patients with cardiovascular disease. Cardiovasc Diabetol (2010) 9:17. doi:10.1186/1475-2840-9-17
    • (2010) Cardiovasc Diabetol , vol.9 , pp. 17
    • Yamaoka-Tojo, M.1    Tojo, T.2    Takahira, N.3    Matsunaga, A.4    Aoyama, N.5    Masuda, T.6
  • 60
    • 84885367670 scopus 로고    scopus 로고
    • Elevated plasma GLP-1 levels and enhanced expression of cardiac GLP-1 receptors as markers of left ventricular systolic dysfunction: a cross-sectional study
    • Hattori A, Kawamura I, Yamada Y, Kanamori H, Aoyama T, Ushikoshi H, et al. Elevated plasma GLP-1 levels and enhanced expression of cardiac GLP-1 receptors as markers of left ventricular systolic dysfunction: a cross-sectional study. BMJ Open (2013) 3(9):e003201. doi:10.1136/bmjopen-2013-003201
    • (2013) BMJ Open , vol.3 , Issue.9
    • Hattori, A.1    Kawamura, I.2    Yamada, Y.3    Kanamori, H.4    Aoyama, T.5    Ushikoshi, H.6
  • 61
    • 84907481915 scopus 로고    scopus 로고
    • GLP-1 secretion is increased by inflammatory stimuli in an IL-6-dependent manner, leading to hyperinsulinemia and blood glucose lowering
    • Kahles F, Meyer C, Möllmann J, Diebold S, Findeisen HM, Lebherz C, et al. GLP-1 secretion is increased by inflammatory stimuli in an IL-6-dependent manner, leading to hyperinsulinemia and blood glucose lowering. Diabetes (2014) 63(10):3221-9. doi:10.2337/db14-0100
    • (2014) Diabetes , vol.63 , Issue.10 , pp. 3221-3229
    • Kahles, F.1    Meyer, C.2    Möllmann, J.3    Diebold, S.4    Findeisen, H.M.5    Lebherz, C.6
  • 62
    • 75549091061 scopus 로고    scopus 로고
    • Incretin-based therapies: viewpoints on the way to consensus
    • Nauck MA, Vilsbøll T, Gallwitz B, Garber A, Madsbad S. Incretin-based therapies: viewpoints on the way to consensus. Diabetes Care (2009) 32(Suppl 2):S223-31. doi:10.2337/dc09-S315
    • (2009) Diabetes Care , vol.32 , pp. S223-S231
    • Nauck, M.A.1    Vilsbøll, T.2    Gallwitz, B.3    Garber, A.4    Madsbad, S.5
  • 63
    • 84946035690 scopus 로고    scopus 로고
    • Incretin-based drugs and adverse pancreatic events: almost a decade later and uncertainty remains
    • Azoulay L. Incretin-based drugs and adverse pancreatic events: almost a decade later and uncertainty remains. Diabetes Care (2015) 38(6):951-3. doi:10.2337/dc15-0347
    • (2015) Diabetes Care , vol.38 , Issue.6 , pp. 951-953
    • Azoulay, L.1
  • 64
    • 75149128665 scopus 로고    scopus 로고
    • Incretin-based therapies for the treatment of type 2 diabetes: evaluation of the risks and benefits
    • Drucker DJ, Sherman SI, Gorelick FS, Bergenstal RM, Sherwin RS, Buse JB. Incretin-based therapies for the treatment of type 2 diabetes: evaluation of the risks and benefits. Diabetes Care (2010) 33(2):428-33. doi:10.2337/dc09-1499
    • (2010) Diabetes Care , vol.33 , Issue.2 , pp. 428-433
    • Drucker, D.J.1    Sherman, S.I.2    Gorelick, F.S.3    Bergenstal, R.M.4    Sherwin, R.S.5    Buse, J.B.6
  • 65
    • 84896731936 scopus 로고    scopus 로고
    • Pancreatic safety of incretin-based drugs-FDA and EMA assessment
    • Egan AG, Blind E, Dunder K, de Graeff PA, Hummer BT, Bourcier T, et al. Pancreatic safety of incretin-based drugs-FDA and EMA assessment. N Engl J Med (2014) 370(9):794-7. doi:10.1056/NEJMp1314078
    • (2014) N Engl J Med , vol.370 , Issue.9 , pp. 794-797
    • Egan, A.G.1    Blind, E.2    Dunder, K.3    de Graeff, P.A.4    Hummer, B.T.5    Bourcier, T.6
  • 66
    • 84923123208 scopus 로고    scopus 로고
    • Blood pressure-lowering effects of incretin-based diabetes therapies
    • Lovshin JA, Zinman B. Blood pressure-lowering effects of incretin-based diabetes therapies. Can J Diabetes (2014) 38(5):364-71. doi:10.1016/j.jcjd.2014.05.001
    • (2014) Can J Diabetes , vol.38 , Issue.5 , pp. 364-371
    • Lovshin, J.A.1    Zinman, B.2
  • 67
    • 84901341959 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 (GLP-1) analog liraglutide inhibits endothelial cell inflammation through a calcium and AMPK dependent mechanism
    • Krasner NM, Ido Y, Ruderman NB, Cacicedo JM. Glucagon-like peptide-1 (GLP-1) analog liraglutide inhibits endothelial cell inflammation through a calcium and AMPK dependent mechanism. PLoS One (2014) 9(5):e97554. doi:10.1371/journal.pone.0097554
    • (2014) PLoS One , vol.9 , Issue.5
    • Krasner, N.M.1    Ido, Y.2    Ruderman, N.B.3    Cacicedo, J.M.4
  • 68
    • 84924413179 scopus 로고    scopus 로고
    • Sitagliptin attenuates transient cerebral ischemia/reperfusion injury in diabetic rats: implication of the oxidative-inflammatory-apoptotic pathway
    • El-Sahar AE, Safar MM, Zaki HF, Attia AS, Ain-Shoka AA. Sitagliptin attenuates transient cerebral ischemia/reperfusion injury in diabetic rats: implication of the oxidative-inflammatory-apoptotic pathway. Life Sci (2015) 126:81-6. doi:10.1016/j.lfs.2015.01.030
    • (2015) Life Sci , vol.126 , pp. 81-86
    • El-Sahar, A.E.1    Safar, M.M.2    Zaki, H.F.3    Attia, A.S.4    Ain-Shoka, A.A.5
  • 69
    • 80053001967 scopus 로고    scopus 로고
    • GLP-1 analogs reduce hepatocyte steatosis and improve survival by enhancing the unfolded protein response and promoting macroautophagy
    • Sharma S, Mells JE, Fu PP, Saxena NK, Anania FA. GLP-1 analogs reduce hepatocyte steatosis and improve survival by enhancing the unfolded protein response and promoting macroautophagy. PLoS One (2011) 6(9):e25269. doi:10.1371/journal.pone.0025269
    • (2011) PLoS One , vol.6 , Issue.9
    • Sharma, S.1    Mells, J.E.2    Fu, P.P.3    Saxena, N.K.4    Anania, F.A.5
  • 70
    • 84910603708 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide-1 receptor agonists on non-alcoholic fatty liver disease and inflammation
    • Wang XC, Gusdon AM, Liu H, Qu S. Effects of glucagon-like peptide-1 receptor agonists on non-alcoholic fatty liver disease and inflammation. World J Gastroenterol (2014) 20(40):14821-30. doi:10.3748/wjg.v20.i40.14821
    • (2014) World J Gastroenterol , vol.20 , Issue.40 , pp. 14821-14830
    • Wang, X.C.1    Gusdon, A.M.2    Liu, H.3    Qu, S.4
  • 71
    • 84927740133 scopus 로고    scopus 로고
    • Anti-inflammatory role of DPP-4 inhibitors in a nondiabetic model of glomerular injury
    • Higashijima Y, Tanaka T, Yamaguchi J, Tanaka S, Nangaku M. Anti-inflammatory role of DPP-4 inhibitors in a nondiabetic model of glomerular injury. Am J Physiol Renal Physiol (2015) 308(8):F878-87. doi:10.1152/ajprenal.00590.2014
    • (2015) Am J Physiol Renal Physiol , vol.308 , Issue.8 , pp. F878-F887
    • Higashijima, Y.1    Tanaka, T.2    Yamaguchi, J.3    Tanaka, S.4    Nangaku, M.5
  • 72
    • 84897829368 scopus 로고    scopus 로고
    • The incretin hormones glucagonlike peptide 1 and glucose-dependent insulinotropic polypeptide are neuroprotective in mouse models of Alzheimer's disease
    • Holscher C. The incretin hormones glucagonlike peptide 1 and glucose-dependent insulinotropic polypeptide are neuroprotective in mouse models of Alzheimer's disease. Alzheimers Dement (2014) 10(1 Suppl):S47-54. doi:10.1016/j.jalz.2013.12.009
    • (2014) Alzheimers Dement , vol.10 , Issue.1 , pp. S47-S54
    • Holscher, C.1
  • 73
    • 84895067918 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 protects synaptic and learning functions from neuroinflammation in rodents
    • Iwai T, Sawabe T, Tanimitsu K, Suzuki M, Sasaki-Hamada S, Oka J. Glucagon-like peptide-1 protects synaptic and learning functions from neuroinflammation in rodents. J Neurosci Res (2014) 92(4):446-54. doi:10.1002/jnr.23335
    • (2014) J Neurosci Res , vol.92 , Issue.4 , pp. 446-454
    • Iwai, T.1    Sawabe, T.2    Tanimitsu, K.3    Suzuki, M.4    Sasaki-Hamada, S.5    Oka, J.6
  • 74
    • 84892516423 scopus 로고    scopus 로고
    • From endocrine to rheumatism: do gut hormones play roles in rheumatoid arthritis?
    • Chen CY, Tsai CY. From endocrine to rheumatism: do gut hormones play roles in rheumatoid arthritis? Rheumatology (Oxford) (2014) 53(2):205-12. doi:10.1093/rheumatology/ket255
    • (2014) Rheumatology (Oxford) , vol.53 , Issue.2 , pp. 205-212
    • Chen, C.Y.1    Tsai, C.Y.2
  • 75
    • 84929306694 scopus 로고    scopus 로고
    • Glucagon like peptide-1 attenuates bleomycin-induced pulmonary fibrosis, involving the inactivation of NF-kappaB in mice
    • Gou S, Zhu T, Wang W, Xiao M, Wang XC, Chen ZH. Glucagon like peptide-1 attenuates bleomycin-induced pulmonary fibrosis, involving the inactivation of NF-kappaB in mice. Int Immunopharmacol (2014) 22(2):498-504. doi:10.1016/j.intimp.2014.07.010
    • (2014) Int Immunopharmacol , vol.22 , Issue.2 , pp. 498-504
    • Gou, S.1    Zhu, T.2    Wang, W.3    Xiao, M.4    Wang, X.C.5    Chen, Z.H.6
  • 76
    • 84878936553 scopus 로고    scopus 로고
    • Extra-pancreatic effects of incretin-based therapies: potential benefit for cardiovascular-risk management in type 2 diabetes
    • van Genugten RE, Möller-Goede DL, van Raalte DH, Diamant M. Extra-pancreatic effects of incretin-based therapies: potential benefit for cardiovascular-risk management in type 2 diabetes. Diabetes Obes Metab (2013) 15(7):593-606. doi:10.1111/dom.12050
    • (2013) Diabetes Obes Metab , vol.15 , Issue.7 , pp. 593-606
    • van Genugten, R.E.1    Möller-Goede, D.L.2    van Raalte, D.H.3    Diamant, M.4
  • 77
    • 84858707110 scopus 로고    scopus 로고
    • The glucagon-like peptide 1 analog liraglutide reduces TNF-alpha-induced oxidative stress and inflammation in endothelial cells
    • Shiraki A, Oyama J, Komoda H, Asaka M, Komatsu A, Sakuma M, et al. The glucagon-like peptide 1 analog liraglutide reduces TNF-alpha-induced oxidative stress and inflammation in endothelial cells. Atherosclerosis (2012) 221(2):375-82. doi:10.1016/j.atherosclerosis.2011.12.039
    • (2012) Atherosclerosis , vol.221 , Issue.2 , pp. 375-382
    • Shiraki, A.1    Oyama, J.2    Komoda, H.3    Asaka, M.4    Komatsu, A.5    Sakuma, M.6
  • 78
    • 84880147886 scopus 로고    scopus 로고
    • Anti-inflammatory effects of exendin-4, a glucagon-like peptide-1 analog, on human peripheral lymphocytes in patients with type 2 diabetes
    • He L, Wong CK, Cheung KK, Yau HC, Fu A, Zhao HL, et al. Anti-inflammatory effects of exendin-4, a glucagon-like peptide-1 analog, on human peripheral lymphocytes in patients with type 2 diabetes. J Diabetes Investig (2013) 4(4):382-92. doi:10.1111/jdi.12063
    • (2013) J Diabetes Investig , vol.4 , Issue.4 , pp. 382-392
    • He, L.1    Wong, C.K.2    Cheung, K.K.3    Yau, H.C.4    Fu, A.5    Zhao, H.L.6
  • 79
    • 84866055251 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 inhibits adipose tissue macrophage infiltration and inflammation in an obese mouse model of diabetes
    • Lee YS, Park MS, Choung JS, Kim SS, Oh HH, Choi CS, et al. Glucagon-like peptide-1 inhibits adipose tissue macrophage infiltration and inflammation in an obese mouse model of diabetes. Diabetologia (2012) 55(9):2456-68. doi:10.1007/s00125-012-2592-3
    • (2012) Diabetologia , vol.55 , Issue.9 , pp. 2456-2468
    • Lee, Y.S.1    Park, M.S.2    Choung, J.S.3    Kim, S.S.4    Oh, H.H.5    Choi, C.S.6
  • 80
    • 84908632327 scopus 로고    scopus 로고
    • SIRT1 mediates the effect of GLP-1 receptor agonist exenatide on ameliorating hepatic steatosis
    • Xu F, Li Z, Zheng X, Liu H, Liang H, Xu H, et al. SIRT1 mediates the effect of GLP-1 receptor agonist exenatide on ameliorating hepatic steatosis. Diabetes (2014) 63(11):3637-46. doi:10.2337/db14-0263
    • (2014) Diabetes , vol.63 , Issue.11 , pp. 3637-3646
    • Xu, F.1    Li, Z.2    Zheng, X.3    Liu, H.4    Liang, H.5    Xu, H.6
  • 81
    • 34447103388 scopus 로고    scopus 로고
    • Increase in DPP-IV in the intestine, liver and kidney of the rat treated with high fat diet and streptozotocin
    • Yang J, Campitelli J, Hu G, Lin Y, Luo J, Xue C. Increase in DPP-IV in the intestine, liver and kidney of the rat treated with high fat diet and streptozotocin. Life Sci (2007) 81(4):272-9. doi:10.1016/j.lfs.2007.04.040
    • (2007) Life Sci , vol.81 , Issue.4 , pp. 272-279
    • Yang, J.1    Campitelli, J.2    Hu, G.3    Lin, Y.4    Luo, J.5    Xue, C.6
  • 82
    • 84878485447 scopus 로고    scopus 로고
    • CD26/DPP4 levels in peripheral blood and T cells in patients with type 2 diabetes mellitus
    • Lee SA, Kim YR, Yang EJ, Kwon EJ, Kim SH, Kang SH, et al. CD26/DPP4 levels in peripheral blood and T cells in patients with type 2 diabetes mellitus. J Clin Endocrinol Metab (2013) 98(6):2553-61. doi:10.1210/jc.2012-4288
    • (2013) J Clin Endocrinol Metab , vol.98 , Issue.6 , pp. 2553-2561
    • Lee, S.A.1    Kim, Y.R.2    Yang, E.J.3    Kwon, E.J.4    Kim, S.H.5    Kang, S.H.6
  • 83
    • 70350328161 scopus 로고    scopus 로고
    • Dipeptidyl peptidase inhibitors, an emerging drug class for inflammatory disease?
    • Yazbeck R, Howarth GS, Abbott CA. Dipeptidyl peptidase inhibitors, an emerging drug class for inflammatory disease? Trends Pharmacol Sci (2009) 30(11):600-7. doi:10.1016/j.tips.2009.08.003
    • (2009) Trends Pharmacol Sci , vol.30 , Issue.11 , pp. 600-607
    • Yazbeck, R.1    Howarth, G.S.2    Abbott, C.A.3
  • 84
    • 0030744259 scopus 로고    scopus 로고
    • Inhibitors of dipeptidyl peptidase IV induce secretion of transforming growth factor-beta 1 in PWM-stimulated PBMC and T cells
    • Reinhold D, Bank U, Bühling F, Lendeckel U, Faust J, Neubert K, et al. Inhibitors of dipeptidyl peptidase IV induce secretion of transforming growth factor-beta 1 in PWM-stimulated PBMC and T cells. Immunology (1997) 91(3):354-60. doi:10.1046/j.1365-2567.1997.d01-2258.x
    • (1997) Immunology , vol.91 , Issue.3 , pp. 354-360
    • Reinhold, D.1    Bank, U.2    Bühling, F.3    Lendeckel, U.4    Faust, J.5    Neubert, K.6
  • 85
    • 84889654817 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibitors: multitarget drugs, not only antidiabetes drugs
    • Zhao Y, Yang L, Zhou Z. Dipeptidyl peptidase-4 inhibitors: multitarget drugs, not only antidiabetes drugs. J Diabetes (2014) 6(1):21-9. doi:10.1111/1753-0407.12063
    • (2014) J Diabetes , vol.6 , Issue.1 , pp. 21-29
    • Zhao, Y.1    Yang, L.2    Zhou, Z.3
  • 86
    • 65149091474 scopus 로고    scopus 로고
    • Genetic ablation or pharmacological blockade of dipeptidyl peptidase IV does not impact T cell-dependent immune responses
    • Vora KA, Porter G, Peng R, Cui Y, Pryor K, Eiermann G, et al. Genetic ablation or pharmacological blockade of dipeptidyl peptidase IV does not impact T cell-dependent immune responses. BMC Immunol (2009) 10:19. doi:10.1186/1471-2172-10-19
    • (2009) BMC Immunol , vol.10 , pp. 19
    • Vora, K.A.1    Porter, G.2    Peng, R.3    Cui, Y.4    Pryor, K.5    Eiermann, G.6
  • 87
    • 84886400216 scopus 로고    scopus 로고
    • Maladaptive immune and inflammatory pathways lead to cardiovascular insulin resistance
    • Aroor AR, McKarns S, Demarco VG, Jia G, Sowers JR. Maladaptive immune and inflammatory pathways lead to cardiovascular insulin resistance. Metabolism (2013) 62(11):1543-52. doi:10.1016/j.metabol.2013.07.001
    • (2013) Metabolism , vol.62 , Issue.11 , pp. 1543-1552
    • Aroor, A.R.1    McKarns, S.2    Demarco, V.G.3    Jia, G.4    Sowers, J.R.5
  • 88
    • 84919712450 scopus 로고    scopus 로고
    • DPP-4 inhibitors repress NLRP3 inflammasome and interleukin-1beta via GLP-1 receptor in macrophages through protein kinase C pathway
    • Dai Y, Dai D, Wang X, Ding Z, Mehta JL. DPP-4 inhibitors repress NLRP3 inflammasome and interleukin-1beta via GLP-1 receptor in macrophages through protein kinase C pathway. Cardiovasc Drugs Ther (2014) 28(5):425-32. doi:10.1007/s10557-014-6539-4
    • (2014) Cardiovasc Drugs Ther , vol.28 , Issue.5 , pp. 425-432
    • Dai, Y.1    Dai, D.2    Wang, X.3    Ding, Z.4    Mehta, J.L.5
  • 89
    • 84903487864 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-IV inhibition prevents blood-retinal barrier breakdown, inflammation and neuronal cell death in the retina of type 1 diabetic rats
    • Gonçalves A, Marques C, Leal E, Ribeiro CF, Reis F, Ambrósio AF, et al. Dipeptidyl peptidase-IV inhibition prevents blood-retinal barrier breakdown, inflammation and neuronal cell death in the retina of type 1 diabetic rats. Biochim Biophys Acta (2014) 1842(9):1454-63. doi:10.1016/j.bbadis.2014.04.013
    • (2014) Biochim Biophys Acta , vol.1842 , Issue.9 , pp. 1454-1463
    • Gonçalves, A.1    Marques, C.2    Leal, E.3    Ribeiro, C.F.4    Reis, F.5    Ambrósio, A.F.6
  • 90
    • 33846453555 scopus 로고    scopus 로고
    • Relationship of serum interleukin-6 and tumor necrosis factor alpha levels with abdominal fat distribution evaluated by ultrasonography in overweight or obese postmenopausal women
    • Fenkci S, Rota S, Sabir N, Sermez Y, Guclu A, Akdag B. Relationship of serum interleukin-6 and tumor necrosis factor alpha levels with abdominal fat distribution evaluated by ultrasonography in overweight or obese postmenopausal women. J Investig Med (2006) 54(8):455-60. doi:10.2310/6650.2006.06010
    • (2006) J Investig Med , vol.54 , Issue.8 , pp. 455-460
    • Fenkci, S.1    Rota, S.2    Sabir, N.3    Sermez, Y.4    Guclu, A.5    Akdag, B.6
  • 92
    • 0035936797 scopus 로고    scopus 로고
    • The TNF and TNF receptor superfamilies: integrating mammalian biology
    • Locksley RM, Killeen N, Lenardo MJ. The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell (2001) 104(4):487-501. doi:10.1016/S0092-8674(01)00237-9
    • (2001) Cell , vol.104 , Issue.4 , pp. 487-501
    • Locksley, R.M.1    Killeen, N.2    Lenardo, M.J.3
  • 93
    • 0036288520 scopus 로고    scopus 로고
    • Tumour necrosis factor alpha converting enzyme (TACE) activity in the colonic mucosa of patients with inflammatory bowel disease
    • Brynskov J, Foegh P, Pedersen G, Ellervik C, Kirkegaard T, Bingham A, et al. Tumour necrosis factor alpha converting enzyme (TACE) activity in the colonic mucosa of patients with inflammatory bowel disease. Gut (2002) 51(1):37-43. doi:10.1136/gut.51.1.37
    • (2002) Gut , vol.51 , Issue.1 , pp. 37-43
    • Brynskov, J.1    Foegh, P.2    Pedersen, G.3    Ellervik, C.4    Kirkegaard, T.5    Bingham, A.6
  • 94
    • 0030756346 scopus 로고    scopus 로고
    • Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function
    • Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GS. Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature (1997) 389(6651):610-4. doi:10.1038/39335
    • (1997) Nature , vol.389 , Issue.6651 , pp. 610-614
    • Uysal, K.T.1    Wiesbrock, S.M.2    Marino, M.W.3    Hotamisligil, G.S.4
  • 95
    • 84946079534 scopus 로고    scopus 로고
    • Chronic exposure to TNFalpha impairs secretion of glucagon-like peptide-1
    • Gagnon J, Sauvé M, Zhao W, Stacey HM, Wiber SC, Bolz SS, et al. Chronic exposure to TNFalpha impairs secretion of glucagon-like peptide-1. Endocrinology (2015) 156(11):3950-60. doi:10.1210/en.2015-1361
    • (2015) Endocrinology , vol.156 , Issue.11 , pp. 3950-3960
    • Gagnon, J.1    Sauvé, M.2    Zhao, W.3    Stacey, H.M.4    Wiber, S.C.5    Bolz, S.S.6
  • 96
    • 84918779133 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha decreases glucagon-like peptide-2 expression by up-regulating G-protein-coupled receptor 120 in Crohn disease
    • Tsukahara T, Watanabe K, Watanabe T, Yamagami H, Sogawa M, Tanigawa T, et al. Tumor necrosis factor alpha decreases glucagon-like peptide-2 expression by up-regulating G-protein-coupled receptor 120 in Crohn disease. Am J Pathol (2015) 185(1):185-96. doi:10.1016/j.ajpath.2014.09.010
    • (2015) Am J Pathol , vol.185 , Issue.1 , pp. 185-196
    • Tsukahara, T.1    Watanabe, K.2    Watanabe, T.3    Yamagami, H.4    Sogawa, M.5    Tanigawa, T.6
  • 98
    • 62349142022 scopus 로고    scopus 로고
    • Effects of tumor necrosis factor alpha inhibition with infliximab on lipid levels and insulin resistance in patients with inflammatory bowel disease
    • Koutroubakis IE, Oustamanolakis P, Malliaraki N, Karmiris K, Chalkiadakis I, Ganotakis E, et al. Effects of tumor necrosis factor alpha inhibition with infliximab on lipid levels and insulin resistance in patients with inflammatory bowel disease. Eur J Gastroenterol Hepatol (2009) 21(3):283-8. doi:10.1097/MEG.0b013e328325d42b
    • (2009) Eur J Gastroenterol Hepatol , vol.21 , Issue.3 , pp. 283-288
    • Koutroubakis, I.E.1    Oustamanolakis, P.2    Malliaraki, N.3    Karmiris, K.4    Chalkiadakis, I.5    Ganotakis, E.6
  • 99
    • 84856827310 scopus 로고    scopus 로고
    • Endocrine and metabolic manifestations in inflammatory bowel disease
    • Tigas S, Tsatsoulis A. Endocrine and metabolic manifestations in inflammatory bowel disease. Ann Gastroenterol (2012) 25(1):37-44
    • (2012) Ann Gastroenterol , vol.25 , Issue.1 , pp. 37-44
    • Tigas, S.1    Tsatsoulis, A.2
  • 100
    • 57849149043 scopus 로고    scopus 로고
    • Carbohydrate and lipid metabolism following infliximab therapy in pediatric Crohn's disease
    • Steiner SJ, Pfefferkorn MD, Fitzgerald JF, Denne SC. Carbohydrate and lipid metabolism following infliximab therapy in pediatric Crohn's disease. Pediatr Res (2008) 64(6):673-6. doi:10.1203/PDR.0b013e318186dde2
    • (2008) Pediatr Res , vol.64 , Issue.6 , pp. 673-676
    • Steiner, S.J.1    Pfefferkorn, M.D.2    Fitzgerald, J.F.3    Denne, S.C.4
  • 101
    • 84876738647 scopus 로고    scopus 로고
    • Long-term etanercept therapy favors weight gain and ameliorates cachexia in rheumatoid arthritis patients: roles of gut hormones and leptin
    • Chen CY, Tsai CY, Lee PC, Lee SD. Long-term etanercept therapy favors weight gain and ameliorates cachexia in rheumatoid arthritis patients: roles of gut hormones and leptin. Curr Pharm Des (2013) 19(10):1956-64. doi:10.2174/1381612811319100014
    • (2013) Curr Pharm Des , vol.19 , Issue.10 , pp. 1956-1964
    • Chen, C.Y.1    Tsai, C.Y.2    Lee, P.C.3    Lee, S.D.4
  • 102
    • 84928568835 scopus 로고    scopus 로고
    • IL-6 as a keystone cytokine in health and disease
    • Hunter CA, Jones SA. IL-6 as a keystone cytokine in health and disease. Nat Immunol (2015) 16(5):448-57. doi:10.1038/ni.3153
    • (2015) Nat Immunol , vol.16 , Issue.5 , pp. 448-457
    • Hunter, C.A.1    Jones, S.A.2
  • 103
    • 79953680176 scopus 로고    scopus 로고
    • Tocilizumab inhibits structural joint damage in rheumatoid arthritis patients with inadequate responses to methotrexate: results from the double-blind treatment phase of a randomized placebo-controlled trial of tocilizumab safety and prevention of structural joint damage at one year
    • Kremer JM, Blanco R, Brzosko M, Burgos-Vargas R, Halland AM, Vernon E, et al. Tocilizumab inhibits structural joint damage in rheumatoid arthritis patients with inadequate responses to methotrexate: results from the double-blind treatment phase of a randomized placebo-controlled trial of tocilizumab safety and prevention of structural joint damage at one year. Arthritis Rheum (2011) 63(3):609-21. doi:10.1002/art.30158
    • (2011) Arthritis Rheum , vol.63 , Issue.3 , pp. 609-621
    • Kremer, J.M.1    Blanco, R.2    Brzosko, M.3    Burgos-Vargas, R.4    Halland, A.M.5    Vernon, E.6
  • 104
    • 84918522920 scopus 로고    scopus 로고
    • IL-6 stimulates intestinal epithelial proliferation and repair after injury
    • Kuhn KA, Manieri NA, Liu TC, Stappenbeck TS. IL-6 stimulates intestinal epithelial proliferation and repair after injury. PLoS One (2014) 9(12):e114195. doi:10.1371/journal.pone.0114195
    • (2014) PLoS One , vol.9 , Issue.12
    • Kuhn, K.A.1    Manieri, N.A.2    Liu, T.C.3    Stappenbeck, T.S.4
  • 105
    • 33644594409 scopus 로고    scopus 로고
    • Association of systemic chemokine concentrations with impaired glucose tolerance and type 2 diabetes: results from the Cooperative Health Research in the Region of Augsburg Survey S4 (KORA S4)
    • Herder C, Haastert B, Müller-Scholze S, Koenig W, Thorand B, Holle R, et al. Association of systemic chemokine concentrations with impaired glucose tolerance and type 2 diabetes: results from the Cooperative Health Research in the Region of Augsburg Survey S4 (KORA S4). Diabetes (2005) 54(Suppl 2):S11-7. doi:10.2337/diabetes.54.suppl_2.S11
    • (2005) Diabetes , vol.54 , pp. S11-S17
    • Herder, C.1    Haastert, B.2    Müller-Scholze, S.3    Koenig, W.4    Thorand, B.5    Holle, R.6
  • 106
    • 0030735542 scopus 로고    scopus 로고
    • Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo
    • Mohamed-Ali V, Goodrick S, Rawesh A, Katz DR, Miles JM, Yudkin JS, et al. Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo. J Clin Endocrinol Metab (1997) 82(12):4196-200. doi:10.1210/jcem.82.12.4450
    • (1997) J Clin Endocrinol Metab , vol.82 , Issue.12 , pp. 4196-4200
    • Mohamed-Ali, V.1    Goodrick, S.2    Rawesh, A.3    Katz, D.R.4    Miles, J.M.5    Yudkin, J.S.6
  • 107
    • 51349111709 scopus 로고    scopus 로고
    • Prolonged interleukin-6 administration enhances glucose tolerance and increases skeletal muscle PPARalpha and UCP2 expression in rats
    • Holmes AG, Mesa JL, Neill BA, Chung J, Carey AL, Steinberg GR, et al. Prolonged interleukin-6 administration enhances glucose tolerance and increases skeletal muscle PPARalpha and UCP2 expression in rats. J Endocrinol (2008) 198(2):367-74. doi:10.1677/JOE-08-0113
    • (2008) J Endocrinol , vol.198 , Issue.2 , pp. 367-374
    • Holmes, A.G.1    Mesa, J.L.2    Neill, B.A.3    Chung, J.4    Carey, A.L.5    Steinberg, G.R.6
  • 108
    • 33646350774 scopus 로고    scopus 로고
    • Direct cross-talk of interleukin-6 and insulin signal transduction via insulin receptor substrate-1 in skeletal muscle cells
    • Weigert C, Hennige AM, Lehmann R, Brodbeck K, Baumgartner F, Schaüble M, et al. Direct cross-talk of interleukin-6 and insulin signal transduction via insulin receptor substrate-1 in skeletal muscle cells. J Biol Chem (2006) 281(11):7060-7. doi:10.1074/jbc.M509782200
    • (2006) J Biol Chem , vol.281 , Issue.11 , pp. 7060-7067
    • Weigert, C.1    Hennige, A.M.2    Lehmann, R.3    Brodbeck, K.4    Baumgartner, F.5    Schaüble, M.6
  • 109
    • 84885031186 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 receptor induced suppression of food intake, and body weight is mediated by central IL-1 and IL-6
    • Shirazi R, Palsdottir V, Collander J, Anesten F, Vogel H, Langlet F, et al. Glucagon-like peptide 1 receptor induced suppression of food intake, and body weight is mediated by central IL-1 and IL-6. Proc Natl Acad Sci U S A (2013) 110(40):16199-204. doi:10.1073/pnas.1306799110
    • (2013) Proc Natl Acad Sci U S A , vol.110 , Issue.40 , pp. 16199-16204
    • Shirazi, R.1    Palsdottir, V.2    Collander, J.3    Anesten, F.4    Vogel, H.5    Langlet, F.6
  • 110
    • 70350561703 scopus 로고    scopus 로고
    • Interleukin-10 prevents diet-induced insulin resistance by attenuating macrophage and cytokine response in skeletal muscle
    • Hong EG, Ko HJ, Cho YR, Kim HJ, Ma Z, Yu TY, et al. Interleukin-10 prevents diet-induced insulin resistance by attenuating macrophage and cytokine response in skeletal muscle. Diabetes (2009) 58(11):2525-35. doi:10.2337/db08-1261
    • (2009) Diabetes , vol.58 , Issue.11 , pp. 2525-2535
    • Hong, E.G.1    Ko, H.J.2    Cho, Y.R.3    Kim, H.J.4    Ma, Z.5    Yu, T.Y.6
  • 111
    • 84966710938 scopus 로고    scopus 로고
    • Role of adiponectin and some other factors linking type 2 diabetes mellitus and obesity
    • Chakraborti CK. Role of adiponectin and some other factors linking type 2 diabetes mellitus and obesity. World J Diabetes (2015) 6(15):1296-308. doi:10.4239/wjd.v6.i15.1296
    • (2015) World J Diabetes , vol.6 , Issue.15 , pp. 1296-1308
    • Chakraborti, C.K.1
  • 112
    • 84905284828 scopus 로고    scopus 로고
    • RANTES (CCL5) reduces glucose-dependent secretion of glucagon-like peptides 1 and 2 and impairs glucose-induced insulin secretion in mice
    • Pais R, Zietek T, Hauner H, Daniel H, Skurk T. RANTES (CCL5) reduces glucose-dependent secretion of glucagon-like peptides 1 and 2 and impairs glucose-induced insulin secretion in mice. Am J Physiol Gastrointest Liver Physiol (2014) 307(3):G330-7. doi:10.1152/ajpgi.00329.2013
    • (2014) Am J Physiol Gastrointest Liver Physiol , vol.307 , Issue.3 , pp. G330-G337
    • Pais, R.1    Zietek, T.2    Hauner, H.3    Daniel, H.4    Skurk, T.5
  • 113
    • 34250899722 scopus 로고    scopus 로고
    • Signal integration in the endoplasmic reticulum unfolded protein response
    • Ron D, Walter P. Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol (2007) 8(7):519-29. doi:10.1038/nrm2199
    • (2007) Nat Rev Mol Cell Biol , vol.8 , Issue.7 , pp. 519-529
    • Ron, D.1    Walter, P.2
  • 114
    • 22244446505 scopus 로고    scopus 로고
    • The mammalian unfolded protein response
    • Schroder M, Kaufman RJ. The mammalian unfolded protein response. Annu Rev Biochem (2005) 74:739-89. doi:10.1146/annurev.biochem.73.011303.074134
    • (2005) Annu Rev Biochem , vol.74 , pp. 739-789
    • Schroder, M.1    Kaufman, R.J.2
  • 115
    • 33751069967 scopus 로고    scopus 로고
    • Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins
    • Rutkowski DT, Arnold SM, Miller CN, Wu J, Li J, Gunnison KM, et al. Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins. PLoS Biol (2006) 4(11):e374. doi:10.1371/journal.pbio.0040374
    • (2006) PLoS Biol , vol.4 , Issue.11
    • Rutkowski, D.T.1    Arnold, S.M.2    Miller, C.N.3    Wu, J.4    Li, J.5    Gunnison, K.M.6
  • 116
    • 33748789479 scopus 로고    scopus 로고
    • Mediators of endoplasmic reticulum stress-induced apoptosis
    • Szegezdi E, Logue SE, Gorman AM, Samali A. Mediators of endoplasmic reticulum stress-induced apoptosis. EMBO Rep (2006) 7(9):880-5. doi:10.1038/sj.embor.7400779
    • (2006) EMBO Rep , vol.7 , Issue.9 , pp. 880-885
    • Szegezdi, E.1    Logue, S.E.2    Gorman, A.M.3    Samali, A.4
  • 117
    • 0035094262 scopus 로고    scopus 로고
    • Increased sensitivity to dextran sodium sulfate colitis in IRE1beta-deficient mice
    • Bertolotti A, Wang X, Novoa I, Jungreis R, Schlessinger K, Cho JH, et al. Increased sensitivity to dextran sodium sulfate colitis in IRE1beta-deficient mice. J Clin Invest (2001) 107(5):585-93. doi:10.1172/JCI11476
    • (2001) J Clin Invest , vol.107 , Issue.5 , pp. 585-593
    • Bertolotti, A.1    Wang, X.2    Novoa, I.3    Jungreis, R.4    Schlessinger, K.5    Cho, J.H.6
  • 118
    • 41549092745 scopus 로고    scopus 로고
    • Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis
    • Heazlewood CK, Cook MC, Eri R, Price GR, Tauro SB, Taupin D, et al. Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis. PLoS Med (2008) 5(3):e54. doi:10.1371/journal.pmed.0050054
    • (2008) PLoS Med , vol.5 , Issue.3
    • Heazlewood, C.K.1    Cook, M.C.2    Eri, R.3    Price, G.R.4    Tauro, S.B.5    Taupin, D.6
  • 119
    • 50249086073 scopus 로고    scopus 로고
    • XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease
    • Kaser A, Lee AH, Franke A, Glickman JN, Zeissig S, Tilg H, et al. XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell (2008) 134(5):743-56. doi:10.1016/j.cell.2008.07.021
    • (2008) Cell , vol.134 , Issue.5 , pp. 743-756
    • Kaser, A.1    Lee, A.H.2    Franke, A.3    Glickman, J.N.4    Zeissig, S.5    Tilg, H.6
  • 120
    • 77951290227 scopus 로고    scopus 로고
    • TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages
    • Martinon F, Chen X, Lee AH, Glimcher LH. TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages. Nat Immunol (2010) 11(5):411-8. doi:10.1038/ni.1857
    • (2010) Nat Immunol , vol.11 , Issue.5 , pp. 411-418
    • Martinon, F.1    Chen, X.2    Lee, A.H.3    Glimcher, L.H.4
  • 121
    • 8644282751 scopus 로고    scopus 로고
    • Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2
    • Deng J, Lu PD, Zhang Y, Scheuner D, Kaufman RJ, Sonenberg N, et al. Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2. Mol Cell Biol (2004) 24(23):10161-8. doi:10.1128/MCB.24.23.10161-10168.2004
    • (2004) Mol Cell Biol , vol.24 , Issue.23 , pp. 10161-10168
    • Deng, J.1    Lu, P.D.2    Zhang, Y.3    Scheuner, D.4    Kaufman, R.J.5    Sonenberg, N.6
  • 122
    • 1842843860 scopus 로고    scopus 로고
    • Coupling endoplasmic reticulum stress to the cell death program
    • Rao RV, Ellerby HM, Bredesen DE. Coupling endoplasmic reticulum stress to the cell death program. Cell Death Differ (2004) 11(4):372-80. doi:10.1038/sj.cdd.4401378
    • (2004) Cell Death Differ , vol.11 , Issue.4 , pp. 372-380
    • Rao, R.V.1    Ellerby, H.M.2    Bredesen, D.E.3
  • 123
    • 33645815074 scopus 로고    scopus 로고
    • Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression
    • Hu P, Han Z, Couvillon AD, Kaufman RJ, Exton JH. Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression. Mol Cell Biol (2006) 26(8):3071-84. doi:10.1128/MCB.26.8.3071-3084.2006
    • (2006) Mol Cell Biol , vol.26 , Issue.8 , pp. 3071-3084
    • Hu, P.1    Han, Z.2    Couvillon, A.D.3    Kaufman, R.J.4    Exton, J.H.5
  • 124
    • 79953044109 scopus 로고    scopus 로고
    • Adenylate kinase 2 links mitochondrial energy metabolism to the induction of the unfolded protein response
    • Burkart A, Shi X, Chouinard M, Corvera S. Adenylate kinase 2 links mitochondrial energy metabolism to the induction of the unfolded protein response. J Biol Chem (2011) 286(6):4081-9. doi:10.1074/jbc.M110.134106
    • (2011) J Biol Chem , vol.286 , Issue.6 , pp. 4081-4089
    • Burkart, A.1    Shi, X.2    Chouinard, M.3    Corvera, S.4
  • 125
    • 0017665008 scopus 로고
    • Induction of two transformation-sensitive membrane polypeptides in normal fibroblasts by a block in glycoprotein synthesis or glucose deprivation
    • Pouyssegur J, Shiu RP, Pastan I. Induction of two transformation-sensitive membrane polypeptides in normal fibroblasts by a block in glycoprotein synthesis or glucose deprivation. Cell (1977) 11(4):941-7. doi:10.1016/0092-8674(77)90305-1
    • (1977) Cell , vol.11 , Issue.4 , pp. 941-947
    • Pouyssegur, J.1    Shiu, R.P.2    Pastan, I.3
  • 126
    • 77950343252 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
    • Hotamisligil GS. Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell (2010) 140(6):900-17. doi:10.1016/j.cell.2010.02.034
    • (2010) Cell , vol.140 , Issue.6 , pp. 900-917
    • Hotamisligil, G.S.1
  • 127
    • 0034973982 scopus 로고    scopus 로고
    • Translational control is required for the unfolded protein response and in vivo glucose homeostasis
    • Scheuner D, Song B, McEwen E, Liu C, Laybutt R, Gillespie P, et al. Translational control is required for the unfolded protein response and in vivo glucose homeostasis. Mol Cell (2001) 7(6):1165-76. doi:10.1016/S1097-2765(01)00265-9
    • (2001) Mol Cell , vol.7 , Issue.6 , pp. 1165-1176
    • Scheuner, D.1    Song, B.2    McEwen, E.3    Liu, C.4    Laybutt, R.5    Gillespie, P.6
  • 128
    • 37149012111 scopus 로고    scopus 로고
    • Induction of endoplasmic reticulum stress-induced beta-cell apoptosis and accumulation of polyubiquitinated proteins by human islet amyloid polypeptide
    • Huang CJ, Haataja L, Gurlo T, Butler AE, Wu X, Soeller WC, et al. Induction of endoplasmic reticulum stress-induced beta-cell apoptosis and accumulation of polyubiquitinated proteins by human islet amyloid polypeptide. Am J Physiol Endocrinol Metab (2007) 293(6):E1656-62. doi:10.1152/ajpendo.00318.2007
    • (2007) Am J Physiol Endocrinol Metab , vol.293 , Issue.6 , pp. E1656-E1662
    • Huang, C.J.1    Haataja, L.2    Gurlo, T.3    Butler, A.E.4    Wu, X.5    Soeller, W.C.6
  • 129
    • 9244231766 scopus 로고    scopus 로고
    • Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress
    • Kharroubi I, Ladrière L, Cardozo AK, Dogusan Z, Cnop M, Eizirik DL. Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress. Endocrinology (2004) 145(11):5087-96. doi:10.1210/en.2004-0478
    • (2004) Endocrinology , vol.145 , Issue.11 , pp. 5087-5096
    • Kharroubi, I.1    Ladrière, L.2    Cardozo, A.K.3    Dogusan, Z.4    Cnop, M.5    Eizirik, D.L.6
  • 130
    • 33845575826 scopus 로고    scopus 로고
    • Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death
    • Borradaile NM, Han X, Harp JD, Gale SE, Ory DS, Schaffer JE. Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death. J Lipid Res (2006) 47(12):2726-37. doi:10.1194/jlr.M600299-JLR200
    • (2006) J Lipid Res , vol.47 , Issue.12 , pp. 2726-2737
    • Borradaile, N.M.1    Han, X.2    Harp, J.D.3    Gale, S.E.4    Ory, D.S.5    Schaffer, J.E.6
  • 131
    • 5644231992 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
    • Ozcan U, Cao Q, Yilmaz E, Lee AH, Iwakoshi NN, Ozdelen E, et al. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science (2004) 306(5695):457-61. doi:10.1126/science.1103160
    • (2004) Science , vol.306 , Issue.5695 , pp. 457-461
    • Ozcan, U.1    Cao, Q.2    Yilmaz, E.3    Lee, A.H.4    Iwakoshi, N.N.5    Ozdelen, E.6
  • 132
    • 0034968330 scopus 로고    scopus 로고
    • Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival
    • Harding HP, Zeng H, Zhang Y, Jungries R, Chung P, Plesken H, et al. Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival. Mol Cell (2001) 7(6):1153-63. doi:10.1016/S1097-2765(01)00264-7
    • (2001) Mol Cell , vol.7 , Issue.6 , pp. 1153-1163
    • Harding, H.P.1    Zeng, H.2    Zhang, Y.3    Jungries, R.4    Chung, P.5    Plesken, H.6
  • 133
    • 19944430402 scopus 로고    scopus 로고
    • Involvement of endoplasmic reticulum stress in insulin resistance and diabetes
    • Nakatani Y, Kaneto H, Kawamori D, Yoshiuchi K, Hatazaki M, Matsuoka TA, et al. Involvement of endoplasmic reticulum stress in insulin resistance and diabetes. J Biol Chem (2005) 280(1):847-51. doi:10.1074/jbc.M411860200
    • (2005) J Biol Chem , vol.280 , Issue.1 , pp. 847-851
    • Nakatani, Y.1    Kaneto, H.2    Kawamori, D.3    Yoshiuchi, K.4    Hatazaki, M.5    Matsuoka, T.A.6
  • 134
    • 67649450485 scopus 로고    scopus 로고
    • Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells
    • Back SH, Scheuner D, Han J, Song B, Ribick M, Wang J, et al. Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells. Cell Metab (2009) 10(1):13-26. doi:10.1016/j.cmet.2009.06.002
    • (2009) Cell Metab , vol.10 , Issue.1 , pp. 13-26
    • Back, S.H.1    Scheuner, D.2    Han, J.3    Song, B.4    Ribick, M.5    Wang, J.6
  • 135
    • 34249857603 scopus 로고    scopus 로고
    • Salicylates trigger protein synthesis inhibition in a protein kinase R-like endoplasmic reticulum kinase-dependent manner
    • Silva AM, Wang D, Komar AA, Castilho BA, Williams BR. Salicylates trigger protein synthesis inhibition in a protein kinase R-like endoplasmic reticulum kinase-dependent manner. J Biol Chem (2007) 282(14):10164-71. doi:10.1074/jbc.M609996200
    • (2007) J Biol Chem , vol.282 , Issue.14 , pp. 10164-10171
    • Silva, A.M.1    Wang, D.2    Komar, A.A.3    Castilho, B.A.4    Williams, B.R.5
  • 136
    • 0035881317 scopus 로고    scopus 로고
    • Anticancer effects of thiazolidinediones are independent of peroxisome proliferator-activated receptor gamma and mediated by inhibition of translation initiation
    • Palakurthi SS, Aktas H, Grubissich LM, Mortensen RM, Halperin JA. Anticancer effects of thiazolidinediones are independent of peroxisome proliferator-activated receptor gamma and mediated by inhibition of translation initiation. Cancer Res (2001) 61(16):6213-8
    • (2001) Cancer Res , vol.61 , Issue.16 , pp. 6213-6218
    • Palakurthi, S.S.1    Aktas, H.2    Grubissich, L.M.3    Mortensen, R.M.4    Halperin, J.A.5
  • 137
    • 33748069813 scopus 로고    scopus 로고
    • Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
    • Ozcan U, Yilmaz E, Ozcan L, Furuhashi M, Vaillancourt E, Smith RO, et al. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science (2006) 313(5790):1137-40. doi:10.1126/science.1128294
    • (2006) Science , vol.313 , Issue.5790 , pp. 1137-1140
    • Ozcan, U.1    Yilmaz, E.2    Ozcan, L.3    Furuhashi, M.4    Vaillancourt, E.5    Smith, R.O.6
  • 138
    • 38149136598 scopus 로고    scopus 로고
    • Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents
    • Ota T, Gayet C, Ginsberg HN. Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents. J Clin Invest (2008) 118(1):316-32. doi:10.1172/JCI32752
    • (2008) J Clin Invest , vol.118 , Issue.1 , pp. 316-332
    • Ota, T.1    Gayet, C.2    Ginsberg, H.N.3
  • 139
    • 71549152580 scopus 로고    scopus 로고
    • Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis
    • Erbay E, Babaev VR, Mayers JR, Makowski L, Charles KN, Snitow ME, et al. Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis. Nat Med (2009) 15(12):1383-91. doi:10.1038/nm.2067
    • (2009) Nat Med , vol.15 , Issue.12 , pp. 1383-1391
    • Erbay, E.1    Babaev, V.R.2    Mayers, J.R.3    Makowski, L.4    Charles, K.N.5    Snitow, M.E.6
  • 140
    • 84876486995 scopus 로고    scopus 로고
    • The unfolded protein response and chemical chaperones reduce protein misfolding and colitis in mice
    • Cao SS, Zimmermann EM, Chuang BM, Song B, Nwokoye A, Wilkinson JE, et al. The unfolded protein response and chemical chaperones reduce protein misfolding and colitis in mice. Gastroenterology (2013) 144(5):989.e-1000.e. doi:10.1053/j.gastro.2013.01.023
    • (2013) Gastroenterology , vol.144 , Issue.5 , pp. 989e-1000e
    • Cao, S.S.1    Zimmermann, E.M.2    Chuang, B.M.3    Song, B.4    Nwokoye, A.5    Wilkinson, J.E.6
  • 141
    • 74749103667 scopus 로고    scopus 로고
    • Disruption of Paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in Agr2-/- mice
    • Zhao F, Edwards R, Dizon D, Afrasiabi K, Mastroianni JR, Geyfman M, et al. Disruption of Paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in Agr2-/- mice. Dev Biol (2010) 338(2):270-9. doi:10.1016/j.ydbio.2009.12.008
    • (2010) Dev Biol , vol.338 , Issue.2 , pp. 270-279
    • Zhao, F.1    Edwards, R.2    Dizon, D.3    Afrasiabi, K.4    Mastroianni, J.R.5    Geyfman, M.6
  • 142
    • 84876998128 scopus 로고    scopus 로고
    • ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response
    • Heijmans J, van Lidth de Jeude JF, Koo BK, Rosekrans SL, Wielenga MC, van de Wetering M, et al. ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response. Cell Rep (2013) 3(4):1128-39. doi:10.1016/j.celrep.2013.02.031
    • (2013) Cell Rep , vol.3 , Issue.4 , pp. 1128-1139
    • Heijmans, J.1    van Lidth de Jeude, J.F.2    Koo, B.K.3    Rosekrans, S.L.4    Wielenga, M.C.5    van de Wetering, M.6
  • 143
    • 84943415049 scopus 로고    scopus 로고
    • Differential molecular and cellular responses of GLP-1 secreting L-cells and pancreatic alpha cells to glucotoxicity and lipotoxicity
    • Vasu S, Moffett RC, McClenaghan NH, Flatt PR. Differential molecular and cellular responses of GLP-1 secreting L-cells and pancreatic alpha cells to glucotoxicity and lipotoxicity. Exp Cell Res (2015) 336(1):100-8. doi:10.1016/j.yexcr.2015.05.022
    • (2015) Exp Cell Res , vol.336 , Issue.1 , pp. 100-108
    • Vasu, S.1    Moffett, R.C.2    McClenaghan, N.H.3    Flatt, P.R.4
  • 144
    • 84875142060 scopus 로고    scopus 로고
    • Bile-acid-mediated decrease in endoplasmic reticulum stress: a potential contributor to the metabolic benefits of ileal interposition surgery in UCD-T2DM rats
    • Cummings BP, Bettaieb A, Graham JL, Kim J, Ma F, Shibata N, et al. Bile-acid-mediated decrease in endoplasmic reticulum stress: a potential contributor to the metabolic benefits of ileal interposition surgery in UCD-T2DM rats. Dis Model Mech (2013) 6(2):443-56. doi:10.1242/dmm.010421
    • (2013) Dis Model Mech , vol.6 , Issue.2 , pp. 443-456
    • Cummings, B.P.1    Bettaieb, A.2    Graham, J.L.3    Kim, J.4    Ma, F.5    Shibata, N.6
  • 145
    • 3242664636 scopus 로고    scopus 로고
    • Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis
    • Rakoff-Nahoum S, Paglino J, Eslami-Varzaneh F, Edberg S, Medzhitov R. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell (2004) 118(2):229-41. doi:10.1016/j.cell.2004.07.002
    • (2004) Cell , vol.118 , Issue.2 , pp. 229-241
    • Rakoff-Nahoum, S.1    Paglino, J.2    Eslami-Varzaneh, F.3    Edberg, S.4    Medzhitov, R.5
  • 146
    • 84875083047 scopus 로고    scopus 로고
    • Adaptive immunity alters distinct host feeding pathways during nematode induced inflammation, a novel mechanism in parasite expulsion
    • Worthington JJ, Samuelson LC, Grencis RK, McLaughlin JT. Adaptive immunity alters distinct host feeding pathways during nematode induced inflammation, a novel mechanism in parasite expulsion. PLoS Pathog (2013) 9(1):e1003122. doi:10.1371/journal.ppat.1003122
    • (2013) PLoS Pathog , vol.9 , Issue.1
    • Worthington, J.J.1    Samuelson, L.C.2    Grencis, R.K.3    McLaughlin, J.T.4
  • 147
    • 84888201738 scopus 로고    scopus 로고
    • Enteroendocrine cells in gastrointestinal pathophysiology
    • Harrison E, Lal S, McLaughlin JT. Enteroendocrine cells in gastrointestinal pathophysiology. Curr Opin Pharmacol (2013) 13(6):941-5. doi:10.1016/j.coph.2013.09.012
    • (2013) Curr Opin Pharmacol , vol.13 , Issue.6 , pp. 941-945
    • Harrison, E.1    Lal, S.2    McLaughlin, J.T.3
  • 148
    • 34447553459 scopus 로고    scopus 로고
    • Immunohistochemical study on the neuroendocrine system of the digestive tract of turbot, Scophthalmus maximus (L.), infected by Enteromyxum scophthalmi (Myxozoa)
    • Bermudez R, Vigliano F, Quiroga MI, Nieto JM, Bosi G, Domeneghini C. Immunohistochemical study on the neuroendocrine system of the digestive tract of turbot, Scophthalmus maximus (L.), infected by Enteromyxum scophthalmi (Myxozoa). Fish Shellfish Immunol (2007) 22(3):252-63. doi:10.1016/j.fsi.2006.05.006
    • (2007) Fish Shellfish Immunol , vol.22 , Issue.3 , pp. 252-263
    • Bermudez, R.1    Vigliano, F.2    Quiroga, M.I.3    Nieto, J.M.4    Bosi, G.5    Domeneghini, C.6
  • 149
    • 34347204910 scopus 로고    scopus 로고
    • CD4+ T cell-mediated immunological control of enterochromaffin cell hyperplasia and 5-hydroxytryptamine production in enteric infection
    • Wang H, Steeds J, Motomura Y, Deng Y, Verma-Gandhu M, El-Sharkawy RT, et al. CD4+ T cell-mediated immunological control of enterochromaffin cell hyperplasia and 5-hydroxytryptamine production in enteric infection. Gut (2007) 56(7):949-57. doi:10.1136/gut.2006.103226
    • (2007) Gut , vol.56 , Issue.7 , pp. 949-957
    • Wang, H.1    Steeds, J.2    Motomura, Y.3    Deng, Y.4    Verma-Gandhu, M.5    El-Sharkawy, R.T.6
  • 150
    • 84869752888 scopus 로고    scopus 로고
    • High densities of serotonin and peptide YY cells in the colon of patients with lymphocytic colitis
    • El-Salhy M, Gundersen D, Hatlebakk JG, Hausken T. High densities of serotonin and peptide YY cells in the colon of patients with lymphocytic colitis. World J Gastroenterol (2012) 18(42):6070-5. doi:10.3748/wjg.v18.i42.6070
    • (2012) World J Gastroenterol , vol.18 , Issue.42 , pp. 6070-6075
    • El-Salhy, M.1    Gundersen, D.2    Hatlebakk, J.G.3    Hausken, T.4
  • 151
    • 84871626306 scopus 로고    scopus 로고
    • Chromogranin A cell density as a diagnostic marker for lymphocytic colitis
    • El-Salhy M, Gundersen D, Hatlebakk JG, Hausken T. Chromogranin A cell density as a diagnostic marker for lymphocytic colitis. Dig Dis Sci (2012) 57(12):3154-9. doi:10.1007/s10620-012-2249-6
    • (2012) Dig Dis Sci , vol.57 , Issue.12 , pp. 3154-3159
    • El-Salhy, M.1    Gundersen, D.2    Hatlebakk, J.G.3    Hausken, T.4
  • 152
    • 34247554965 scopus 로고    scopus 로고
    • Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
    • Rioux JD, Xavier RJ, Taylor KD, Silverberg MS, Goyette P, Huett A, et al. Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat Genet (2007) 39(5):596-604. doi:10.1038/ng2032
    • (2007) Nat Genet , vol.39 , Issue.5 , pp. 596-604
    • Rioux, J.D.1    Xavier, R.J.2    Taylor, K.D.3    Silverberg, M.S.4    Goyette, P.5    Huett, A.6
  • 153
    • 41149103489 scopus 로고    scopus 로고
    • Autoantibodies against ubiquitination factor E4A (UBE4A) are associated with severity of Crohn's disease
    • Sakiyama T, Fujita H, Tsubouchi H. Autoantibodies against ubiquitination factor E4A (UBE4A) are associated with severity of Crohn's disease. Inflamm Bowel Dis (2008) 14(3):310-7. doi:10.1002/ibd.20328
    • (2008) Inflamm Bowel Dis , vol.14 , Issue.3 , pp. 310-317
    • Sakiyama, T.1    Fujita, H.2    Tsubouchi, H.3
  • 154
    • 84865795136 scopus 로고    scopus 로고
    • Enteroendocrine cells in terminal ileal Crohn's disease
    • Moran GW, Pennock J, McLaughlin JT. Enteroendocrine cells in terminal ileal Crohn's disease. J Crohns Colitis (2012) 6(9):871-80. doi:10.1016/j.crohns.2012.01.013
    • (2012) J Crohns Colitis , vol.6 , Issue.9 , pp. 871-880
    • Moran, G.W.1    Pennock, J.2    McLaughlin, J.T.3
  • 155
    • 67649637125 scopus 로고    scopus 로고
    • Rejection reversibly alters enteroendocrine cell renewal in the transplanted small intestine
    • Fishbein TM, Novitskiy G, Lough DM, Matsumoto C, Kaufman SS, Shetty K, et al. Rejection reversibly alters enteroendocrine cell renewal in the transplanted small intestine. Am J Transplant (2009) 9(7):1620-8. doi:10.1111/j.1600-6143.2009.02681.x
    • (2009) Am J Transplant , vol.9 , Issue.7 , pp. 1620-1628
    • Fishbein, T.M.1    Novitskiy, G.2    Lough, D.M.3    Matsumoto, C.4    Kaufman, S.S.5    Shetty, K.6
  • 156
    • 84932618204 scopus 로고    scopus 로고
    • Intestinal neuroendocrine cells and goblet cells are mediators of IL-17A-amplified epithelial IL-17C production in human inflammatory bowel disease
    • Friedrich M, Diegelmann J, Schauber J, Auernhammer CJ, Brand S. Intestinal neuroendocrine cells and goblet cells are mediators of IL-17A-amplified epithelial IL-17C production in human inflammatory bowel disease. Mucosal Immunol (2015) 8(4):943-58. doi:10.1038/mi.2014.124
    • (2015) Mucosal Immunol , vol.8 , Issue.4 , pp. 943-958
    • Friedrich, M.1    Diegelmann, J.2    Schauber, J.3    Auernhammer, C.J.4    Brand, S.5
  • 157
    • 84885576350 scopus 로고    scopus 로고
    • Circulating leptin and adiponectin and their relation to glucose metabolism in children with Crohn's disease and ulcerative colitis
    • Chouliaras G, Panayotou I, Margoni D, Mantzou E, Pervanidou P, Manios Y, et al. Circulating leptin and adiponectin and their relation to glucose metabolism in children with Crohn's disease and ulcerative colitis. Pediatr Res (2013) 74(4):420-6. doi:10.1038/pr.2013.114
    • (2013) Pediatr Res , vol.74 , Issue.4 , pp. 420-426
    • Chouliaras, G.1    Panayotou, I.2    Margoni, D.3    Mantzou, E.4    Pervanidou, P.5    Manios, Y.6
  • 158
    • 84901985892 scopus 로고    scopus 로고
    • Systemic metabolic signaling in acute and chronic gastrointestinal inflammation of inflammatory bowel diseases
    • Karrasch T, Obermeier F, Straub RH. Systemic metabolic signaling in acute and chronic gastrointestinal inflammation of inflammatory bowel diseases. Horm Metab Res (2014) 46(6):445-51. doi:10.1055/s-0034-1374587
    • (2014) Horm Metab Res , vol.46 , Issue.6 , pp. 445-451
    • Karrasch, T.1    Obermeier, F.2    Straub, R.H.3
  • 159
    • 84902209342 scopus 로고    scopus 로고
    • Increased pulse wave velocity and relationship with inflammation, insulin, and insulin resistance in inflammatory bowel disease
    • Korkmaz H, Sahin F, Ipekci SH, Temel T, Kebapcilar L. Increased pulse wave velocity and relationship with inflammation, insulin, and insulin resistance in inflammatory bowel disease. Eur J Gastroenterol Hepatol (2014) 26(7):725-32. doi:10.1097/MEG.0000000000000104
    • (2014) Eur J Gastroenterol Hepatol , vol.26 , Issue.7 , pp. 725-732
    • Korkmaz, H.1    Sahin, F.2    Ipekci, S.H.3    Temel, T.4    Kebapcilar, L.5
  • 160
    • 58149472945 scopus 로고    scopus 로고
    • Circulating adipokines and the protective effects of hyperinsulinemia in inflammatory bowel disease
    • Valentini L, Wirth EK, Schweizer U, Hengstermann S, Schaper L, Koernicke T, et al. Circulating adipokines and the protective effects of hyperinsulinemia in inflammatory bowel disease. Nutrition (2009) 25(2):172-81. doi:10.1016/j.nut.2008.07.020
    • (2009) Nutrition , vol.25 , Issue.2 , pp. 172-181
    • Valentini, L.1    Wirth, E.K.2    Schweizer, U.3    Hengstermann, S.4    Schaper, L.5    Koernicke, T.6
  • 162
    • 29744458362 scopus 로고    scopus 로고
    • Increased insulin resistance and beta cell activity in patients with Crohn's disease
    • Bregenzer N, Hartmann A, Strauch U, Schölmerich J, Andus T, Bollheimer LC. Increased insulin resistance and beta cell activity in patients with Crohn's disease. Inflamm Bowel Dis (2006) 12(1):53-6. doi:10.1097/01.MIB.0000195975.97673.f5
    • (2006) Inflamm Bowel Dis , vol.12 , Issue.1 , pp. 53-56
    • Bregenzer, N.1    Hartmann, A.2    Strauch, U.3    Schölmerich, J.4    Andus, T.5    Bollheimer, L.C.6
  • 163
    • 84877127350 scopus 로고    scopus 로고
    • Crohn's disease affecting the small bowel is associated with reduced appetite and elevated levels of circulating gut peptides
    • Moran GW, Leslie FC, McLaughlin JT. Crohn's disease affecting the small bowel is associated with reduced appetite and elevated levels of circulating gut peptides. Clin Nutr (2013) 32(3):404-11. doi:10.1016/j.clnu.2012.08.024
    • (2013) Clin Nutr , vol.32 , Issue.3 , pp. 404-411
    • Moran, G.W.1    Leslie, F.C.2    McLaughlin, J.T.3
  • 166
    • 0030728376 scopus 로고    scopus 로고
    • Colonic endocrine cells in inflammatory bowel disease
    • El-Salhy M, Danielsson A, Stenling R, Grimelius L. Colonic endocrine cells in inflammatory bowel disease. J Intern Med (1997) 242(5):413-9. doi:10.1046/j.1365-2796.1997.00237.x
    • (1997) J Intern Med , vol.242 , Issue.5 , pp. 413-419
    • El-Salhy, M.1    Danielsson, A.2    Stenling, R.3    Grimelius, L.4
  • 167
    • 72249097354 scopus 로고    scopus 로고
    • Mechanisms of gastric emptying disturbances in chronic and acute inflammation of the distal gastrointestinal tract
    • Keller J, Beglinger C, Holst JJ, Andresen V, Layer P. Mechanisms of gastric emptying disturbances in chronic and acute inflammation of the distal gastrointestinal tract. Am J Physiol Gastrointest Liver Physiol (2009) 297(5):G861-8. doi:10.1152/ajpgi.00145.2009
    • (2009) Am J Physiol Gastrointest Liver Physiol , vol.297 , Issue.5 , pp. G861-G868
    • Keller, J.1    Beglinger, C.2    Holst, J.J.3    Andresen, V.4    Layer, P.5
  • 170
    • 84862768978 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 expression is reduced in Crohn's disease
    • Moran GW, O'Neill C, Padfield P, McLaughlin JT. Dipeptidyl peptidase-4 expression is reduced in Crohn's disease. Regul Pept (2012) 177(1-3):40-5. doi:10.1016/j.regpep.2012.04.006
    • (2012) Regul Pept , vol.177 , Issue.1-3 , pp. 40-45
    • Moran, G.W.1    O'Neill, C.2    Padfield, P.3    McLaughlin, J.T.4
  • 171
    • 84884541899 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibitor anagliptin facilitates restoration of dextran sulfate sodium-induced colitis
    • Mimura S, Ando T, Ishiguro K, Maeda O, Watanabe O, Ujihara M, et al. Dipeptidyl peptidase-4 inhibitor anagliptin facilitates restoration of dextran sulfate sodium-induced colitis. Scand J Gastroenterol (2013) 48(10):1152-9. doi:10.3109/00365521.2013.832366
    • (2013) Scand J Gastroenterol , vol.48 , Issue.10 , pp. 1152-1159
    • Mimura, S.1    Ando, T.2    Ishiguro, K.3    Maeda, O.4    Watanabe, O.5    Ujihara, M.6
  • 172
    • 84863115292 scopus 로고    scopus 로고
    • Disruption of the murine Glp2r impairs Paneth cell function and increases susceptibility to small bowel enteritis
    • Lee SJ, Lee J, Li KK, Holland D, Maughan H, Guttman DS, et al. Disruption of the murine Glp2r impairs Paneth cell function and increases susceptibility to small bowel enteritis. Endocrinology (2012) 153(3):1141-51. doi:10.1210/en.2011-1954
    • (2012) Endocrinology , vol.153 , Issue.3 , pp. 1141-1151
    • Lee, S.J.1    Lee, J.2    Li, K.K.3    Holland, D.4    Maughan, H.5    Guttman, D.S.6
  • 173
    • 84890493862 scopus 로고    scopus 로고
    • Purified PEGylated porcine glucagon-like peptide-2 reduces the severity of colonic injury in a murine model of experimental colitis
    • Qi KK, Wu J, Wan J, Men XM, Xu ZW. Purified PEGylated porcine glucagon-like peptide-2 reduces the severity of colonic injury in a murine model of experimental colitis. Peptides (2014) 52:11-8. doi:10.1016/j.peptides.2013.11.012
    • (2014) Peptides , vol.52 , pp. 11-18
    • Qi, K.K.1    Wu, J.2    Wan, J.3    Men, X.M.4    Xu, Z.W.5
  • 174
    • 0032714919 scopus 로고    scopus 로고
    • Glucagon-like peptide 2 decreases mortality and reduces the severity of indomethacin-induced murine enteritis
    • Boushey RP, Yusta B, Drucker DJ. Glucagon-like peptide 2 decreases mortality and reduces the severity of indomethacin-induced murine enteritis. Am J Physiol (1999) 277(5 Pt 1):E937-47
    • (1999) Am J Physiol , vol.277 , Issue.5 , pp. E937-E947
    • Boushey, R.P.1    Yusta, B.2    Drucker, D.J.3
  • 175
    • 0034113232 scopus 로고    scopus 로고
    • Treatment of inflammatory bowel disease in a rodent model with the intestinal growth factor glucagon-like peptide-2
    • Alavi K, Schwartz MZ, Palazzo JP, Prasad R. Treatment of inflammatory bowel disease in a rodent model with the intestinal growth factor glucagon-like peptide-2. J Pediatr Surg (2000) 35(6):847-51. doi:10.1053/jpsu.2000.6861
    • (2000) J Pediatr Surg , vol.35 , Issue.6 , pp. 847-851
    • Alavi, K.1    Schwartz, M.Z.2    Palazzo, J.P.3    Prasad, R.4
  • 176
    • 0032621235 scopus 로고    scopus 로고
    • Human [Gly2]GLP-2 reduces the severity of colonic injury in a murine model of experimental colitis
    • Drucker DJ, Yusta B, Boushey RP, DeForest L, Brubaker PL. Human [Gly2]GLP-2 reduces the severity of colonic injury in a murine model of experimental colitis. Am J Physiol (1999) 276(1 Pt 1):G79-91
    • (1999) Am J Physiol , vol.276 , Issue.1 , pp. G79-G91
    • Drucker, D.J.1    Yusta, B.2    Boushey, R.P.3    DeForest, L.4    Brubaker, P.L.5
  • 177
    • 77952679996 scopus 로고    scopus 로고
    • Teduglutide, a novel mucosally active analog of glucagon-like peptide-2 (GLP-2) for the treatment of moderate to severe Crohn's disease
    • Buchman AL, Katz S, Fang JC, Bernstein CN, Abou-Assi SG, Teduglutide Study Group. Teduglutide, a novel mucosally active analog of glucagon-like peptide-2 (GLP-2) for the treatment of moderate to severe Crohn's disease. Inflamm Bowel Dis (2010) 16(6):962-73. doi:10.1002/ibd.21117
    • (2010) Inflamm Bowel Dis , vol.16 , Issue.6 , pp. 962-973
    • Buchman, A.L.1    Katz, S.2    Fang, J.C.3    Bernstein, C.N.4    Abou-Assi, S.G.5
  • 178
    • 79958187560 scopus 로고    scopus 로고
    • Randomised placebo-controlled trial of teduglutide in reducing parenteral nutrition and/or intravenous fluid requirements in patients with short bowel syndrome
    • Jeppesen PB, Gilroy R, Pertkiewicz M, Allard JP, Messing B, O'Keefe SJ. Randomised placebo-controlled trial of teduglutide in reducing parenteral nutrition and/or intravenous fluid requirements in patients with short bowel syndrome. Gut (2011) 60(7):902-14. doi:10.1136/gut.2010.218271
    • (2011) Gut , vol.60 , Issue.7 , pp. 902-914
    • Jeppesen, P.B.1    Gilroy, R.2    Pertkiewicz, M.3    Allard, J.P.4    Messing, B.5    O'Keefe, S.J.6
  • 179
    • 84869881880 scopus 로고    scopus 로고
    • Teduglutide reduces need for parenteral support among patients with short bowel syndrome with intestinal failure
    • Jeppesen PB, Pertkiewicz M, Messing B, Iyer K, Seidner DL, O'keefe SJ, et al. Teduglutide reduces need for parenteral support among patients with short bowel syndrome with intestinal failure. Gastroenterology (2012) 143(6):1473.e-81.e. doi:10.1053/j.gastro.2012.09.007
    • (2012) Gastroenterology , vol.143 , Issue.6 , pp. 1473e-1481e
    • Jeppesen, P.B.1    Pertkiewicz, M.2    Messing, B.3    Iyer, K.4    Seidner, D.L.5    O'keefe, S.J.6
  • 180
    • 68449097985 scopus 로고    scopus 로고
    • WNT/beta-catenin increases the production of incretins by entero-endocrine cells
    • García-Martínez JM, Chocarro-Calvo A, Moya CM, García-Jiménez C. WNT/beta-catenin increases the production of incretins by entero-endocrine cells. Diabetologia (2009) 52(9):1913-24. doi:10.1007/s00125-009-1429-1
    • (2009) Diabetologia , vol.52 , Issue.9 , pp. 1913-1924
    • García-Martínez, J.M.1    Chocarro-Calvo, A.2    Moya, C.M.3    García-Jiménez, C.4
  • 181
    • 51249114497 scopus 로고    scopus 로고
    • WNT signalling is both an inducer and effector of glucagon-like peptide-1
    • Gustafson B, Smith U. WNT signalling is both an inducer and effector of glucagon-like peptide-1. Diabetologia (2008) 51(10):1768-70. doi:10.1007/s00125-008-1109-6
    • (2008) Diabetologia , vol.51 , Issue.10 , pp. 1768-1770
    • Gustafson, B.1    Smith, U.2
  • 182
    • 17444423289 scopus 로고    scopus 로고
    • Wnt signaling in the intestinal epithelium: from endoderm to cancer
    • Gregorieff A, Clevers H. Wnt signaling in the intestinal epithelium: from endoderm to cancer. Genes Dev (2005) 19(8):877-90. doi:10.1101/gad.1295405
    • (2005) Genes Dev , vol.19 , Issue.8 , pp. 877-890
    • Gregorieff, A.1    Clevers, H.2
  • 183
    • 35748957503 scopus 로고    scopus 로고
    • The physiology of glucagon-like peptide 1
    • Holst JJ. The physiology of glucagon-like peptide 1. Physiol Rev (2007) 87(4):1409-39. doi:10.1152/physrev.00034.2006
    • (2007) Physiol Rev , vol.87 , Issue.4 , pp. 1409-1439
    • Holst, J.J.1
  • 184
    • 0032944601 scopus 로고    scopus 로고
    • The influence of the colon on postprandial glucagon-like peptide 1 (7-36) amide concentration in man
    • Robertson MD, Livesey G, Morgan LM, Hampton SM, Mathers JC. The influence of the colon on postprandial glucagon-like peptide 1 (7-36) amide concentration in man. J Endocrinol (1999) 161(1):25-31. doi:10.1677/joe.0.1610025
    • (1999) J Endocrinol , vol.161 , Issue.1 , pp. 25-31
    • Robertson, M.D.1    Livesey, G.2    Morgan, L.M.3    Hampton, S.M.4    Mathers, J.C.5
  • 185
    • 0022515907 scopus 로고
    • Enteroendocrine cell hyperplasia, carcinoid tumours and adenocarcinoma in long-standing ulcerative colitis
    • Gledhill A, Hall PA, Cruse JP, Pollock DJ. Enteroendocrine cell hyperplasia, carcinoid tumours and adenocarcinoma in long-standing ulcerative colitis. Histopathology (1986) 10(5):501-8. doi:10.1111/j.1365-2559.1986.tb02501.x
    • (1986) Histopathology , vol.10 , Issue.5 , pp. 501-508
    • Gledhill, A.1    Hall, P.A.2    Cruse, J.P.3    Pollock, D.J.4
  • 186
    • 84874786762 scopus 로고    scopus 로고
    • Lactocepin as a protective microbial structure in the context of IBD
    • Hormannsperger G, von Schillde MA, Haller D. Lactocepin as a protective microbial structure in the context of IBD. Gut Microbes (2013) 4(2):152-7. doi:10.4161/gmic.23444
    • (2013) Gut Microbes , vol.4 , Issue.2 , pp. 152-157
    • Hormannsperger, G.1    von Schillde, M.A.2    Haller, D.3
  • 187
    • 84902300630 scopus 로고    scopus 로고
    • Gut microbiota, probiotics and diabetes
    • Gomes AC, Bueno AA, de Souza RG, Mota JF. Gut microbiota, probiotics and diabetes. Nutr J (2014) 13:60. doi:10.1186/1475-2891-13-60
    • (2014) Nutr J , vol.13 , pp. 60
    • Gomes, A.C.1    Bueno, A.A.2    de Souza, R.G.3    Mota, J.F.4
  • 188
    • 35848947008 scopus 로고    scopus 로고
    • Modulation of glucagon-like peptide 1 and energy metabolism by inulin and oligofructose: experimental data
    • Delzenne NM, Cani PD, Neyrinck AM. Modulation of glucagon-like peptide 1 and energy metabolism by inulin and oligofructose: experimental data. J Nutr (2007) 137(11 Suppl):2547S-51S
    • (2007) J Nutr , vol.137 , Issue.11 , pp. 2547S-2551S
    • Delzenne, N.M.1    Cani, P.D.2    Neyrinck, A.M.3
  • 189
    • 0028026180 scopus 로고
    • Immunocytochemical study of intestinal endocrine cells in germ-free mice
    • Nogueira AM, Barbosa AJ. Immunocytochemical study of intestinal endocrine cells in germ-free mice. Eur J Histochem (1994) 38(3):213-8
    • (1994) Eur J Histochem , vol.38 , Issue.3 , pp. 213-218
    • Nogueira, A.M.1    Barbosa, A.J.2
  • 190
    • 84907228623 scopus 로고    scopus 로고
    • Evidence for the gut microbiota short-chain fatty acids as key pathophysiological molecules improving diabetes
    • Puddu A, Sanguineti R, Montecucco F, Viviani GL. Evidence for the gut microbiota short-chain fatty acids as key pathophysiological molecules improving diabetes. Mediators Inflamm (2014) 2014:162021. doi:10.1155/2014/162021
    • (2014) Mediators Inflamm , vol.2014
    • Puddu, A.1    Sanguineti, R.2    Montecucco, F.3    Viviani, G.L.4
  • 191
    • 79955932718 scopus 로고    scopus 로고
    • Potential beneficial effects of butyrate in intestinal and extraintestinal diseases
    • Canani RB, Costanzo MD, Leone L, Pedata M, Meli R, Calignano A. Potential beneficial effects of butyrate in intestinal and extraintestinal diseases. World J Gastroenterol (2011) 17(12):1519-28. doi:10.3748/wjg.v17.i12
    • (2011) World J Gastroenterol , vol.17 , Issue.12 , pp. 1519-1528
    • Canani, R.B.1    Costanzo, M.D.2    Leone, L.3    Pedata, M.4    Meli, R.5    Calignano, A.6
  • 192
    • 84892874108 scopus 로고    scopus 로고
    • Effects of short chain fatty acid producing bacteria on epigenetic regulation of FFAR3 in type 2 diabetes and obesity
    • Remely M, Aumueller E, Merold C, Dworzak S, Hippe B, Zanner J, et al. Effects of short chain fatty acid producing bacteria on epigenetic regulation of FFAR3 in type 2 diabetes and obesity. Gene (2014) 537(1):85-92. doi:10.1016/j.gene.2013.11.081
    • (2014) Gene , vol.537 , Issue.1 , pp. 85-92
    • Remely, M.1    Aumueller, E.2    Merold, C.3    Dworzak, S.4    Hippe, B.5    Zanner, J.6
  • 193
    • 84883418106 scopus 로고    scopus 로고
    • Beneficial metabolic effects of a probiotic via butyrate-induced GLP-1 hormone secretion
    • Yadav H, Lee JH, Lloyd J, Walter P, Rane SG. Beneficial metabolic effects of a probiotic via butyrate-induced GLP-1 hormone secretion. J Biol Chem (2013) 288(35):25088-97. doi:10.1074/jbc.M113.452516
    • (2013) J Biol Chem , vol.288 , Issue.35 , pp. 25088-25097
    • Yadav, H.1    Lee, J.H.2    Lloyd, J.3    Walter, P.4    Rane, S.G.5
  • 194
    • 80755152887 scopus 로고    scopus 로고
    • Responses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice
    • Everard A, Lazarevic V, Derrien M, Girard M, Muccioli GG, Neyrinck AM, et al. Responses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice. Diabetes (2011) 60(11):2775-86. doi:10.2337/db11-0227
    • (2011) Diabetes , vol.60 , Issue.11 , pp. 2775-2786
    • Everard, A.1    Lazarevic, V.2    Derrien, M.3    Girard, M.4    Muccioli, G.G.5    Neyrinck, A.M.6
  • 195
    • 5444248493 scopus 로고    scopus 로고
    • Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium
    • Derrien M, Vaughan EE, Plugge CM, de Vos WM. Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium. Int J Syst Evol Microbiol (2004) 54(Pt 5):1469-76. doi:10.1099/ijs.0.02873-0
    • (2004) Int J Syst Evol Microbiol , vol.54 , pp. 1469-1476
    • Derrien, M.1    Vaughan, E.E.2    Plugge, C.M.3    de Vos, W.M.4
  • 196
    • 84878465280 scopus 로고    scopus 로고
    • Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity
    • Everard A, Belzer C, Geurts L, Ouwerkerk JP, Druart C, Bindels LB, et al. Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Proc Natl Acad Sci U S A (2013) 110(22):9066-71. doi:10.1073/pnas.1219451110
    • (2013) Proc Natl Acad Sci U S A , vol.110 , Issue.22 , pp. 9066-9071
    • Everard, A.1    Belzer, C.2    Geurts, L.3    Ouwerkerk, J.P.4    Druart, C.5    Bindels, L.B.6
  • 197
    • 0000422498 scopus 로고
    • The intraluminal phase of fat digestion in man: the lipid content of the micellar and oil phases of intestinal content obtained during fat digestion and absorption
    • Hofmann AF, Borgstroem B. The intraluminal phase of fat digestion in man: the lipid content of the micellar and oil phases of intestinal content obtained during fat digestion and absorption. J Clin Invest (1964) 43:247-57. doi:10.1172/JCI104909
    • (1964) J Clin Invest , vol.43 , pp. 247-257
    • Hofmann, A.F.1    Borgstroem, B.2
  • 198
    • 70350292362 scopus 로고    scopus 로고
    • Bile-acid-activated receptors: targeting TGR5 and farnesoid-X-receptor in lipid and glucose disorders
    • Fiorucci S, Mencarelli A, Palladino G, Cipriani S. Bile-acid-activated receptors: targeting TGR5 and farnesoid-X-receptor in lipid and glucose disorders. Trends Pharmacol Sci (2009) 30(11):570-80. doi:10.1016/j.tips.2009.08.001
    • (2009) Trends Pharmacol Sci , vol.30 , Issue.11 , pp. 570-580
    • Fiorucci, S.1    Mencarelli, A.2    Palladino, G.3    Cipriani, S.4
  • 199
    • 84922758254 scopus 로고    scopus 로고
    • Bile acids as metabolic regulators
    • Li T, Chiang JY. Bile acids as metabolic regulators. Curr Opin Gastroenterol (2015) 31(2):159-65. doi:10.1097/MOG.0000000000000156
    • (2015) Curr Opin Gastroenterol , vol.31 , Issue.2 , pp. 159-165
    • Li, T.1    Chiang, J.Y.2
  • 200
    • 84919725262 scopus 로고    scopus 로고
    • Intestinal microbiota and type 2 diabetes: from mechanism insights to therapeutic perspective
    • Han JL, Lin HL. Intestinal microbiota and type 2 diabetes: from mechanism insights to therapeutic perspective. World J Gastroenterol (2014) 20(47):17737-45. doi:10.3748/wjg.v20.i47.17737
    • (2014) World J Gastroenterol , vol.20 , Issue.47 , pp. 17737-17745
    • Han, J.L.1    Lin, H.L.2
  • 201
    • 2542435874 scopus 로고    scopus 로고
    • Bile acids regulate gluconeogenic gene expression via small heterodimer partner-mediated repression of hepatocyte nuclear factor 4 and Foxo1
    • Yamagata K, Daitoku H, Shimamoto Y, Matsuzaki H, Hirota K, Ishida J, et al. Bile acids regulate gluconeogenic gene expression via small heterodimer partner-mediated repression of hepatocyte nuclear factor 4 and Foxo1. J Biol Chem (2004) 279(22):23158-65. doi:10.1074/jbc.M314322200
    • (2004) J Biol Chem , vol.279 , Issue.22 , pp. 23158-23165
    • Yamagata, K.1    Daitoku, H.2    Shimamoto, Y.3    Matsuzaki, H.4    Hirota, K.5    Ishida, J.6
  • 202
    • 84873342775 scopus 로고    scopus 로고
    • Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist
    • Sayin SI, Wahlström A, Felin J, Jäntti S, Marschall HU, Bamberg K, et al. Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist. Cell Metab (2013) 17(2):225-35. doi:10.1016/j.cmet.2013.01.003
    • (2013) Cell Metab , vol.17 , Issue.2 , pp. 225-235
    • Sayin, S.I.1    Wahlström, A.2    Felin, J.3    Jäntti, S.4    Marschall, H.U.5    Bamberg, K.6
  • 203
    • 33644752102 scopus 로고    scopus 로고
    • Mechanism of growth inhibition by free bile acids in lactobacilli and bifidobacteria
    • Kurdi P, Kawanishi K, Mizutani K, Yokota A. Mechanism of growth inhibition by free bile acids in lactobacilli and bifidobacteria. J Bacteriol (2006) 188(5):1979-86. doi:10.1128/JB.188.5.1979-1986.2006
    • (2006) J Bacteriol , vol.188 , Issue.5 , pp. 1979-1986
    • Kurdi, P.1    Kawanishi, K.2    Mizutani, K.3    Yokota, A.4
  • 204
    • 84905273290 scopus 로고    scopus 로고
    • Bile acid sequestrants in type 2 diabetes: potential effects on GLP1 secretion
    • Sonne DP, Hansen M, Knop FK. Bile acid sequestrants in type 2 diabetes: potential effects on GLP1 secretion. Eur J Endocrinol (2014) 171(2):R47-65. doi:10.1530/EJE-14-0154
    • (2014) Eur J Endocrinol , vol.171 , Issue.2 , pp. R47-R65
    • Sonne, D.P.1    Hansen, M.2    Knop, F.K.3
  • 205
    • 84895775124 scopus 로고    scopus 로고
    • Bile acid sequestrants: glucose-lowering mechanisms and efficacy in type 2 diabetes
    • Hansen M, Sonne DP, Knop FK. Bile acid sequestrants: glucose-lowering mechanisms and efficacy in type 2 diabetes. Curr Diab Rep (2014) 14(5):482. doi:10.1007/s11892-014-0482-4
    • (2014) Curr Diab Rep , vol.14 , Issue.5 , pp. 482
    • Hansen, M.1    Sonne, D.P.2    Knop, F.K.3
  • 206
    • 84923931916 scopus 로고    scopus 로고
    • Increased GIP signaling induces adipose inflammation via a HIF-1alpha-dependent pathway and impairs insulin sensitivity in mice
    • Chen S, Okahara F, Osaki N, Shimotoyodome A. Increased GIP signaling induces adipose inflammation via a HIF-1alpha-dependent pathway and impairs insulin sensitivity in mice. Am J Physiol Endocrinol Metab (2015) 308(5):E414-25. doi:10.1152/ajpendo.00418.2014
    • (2015) Am J Physiol Endocrinol Metab , vol.308 , Issue.5 , pp. E414-E425
    • Chen, S.1    Okahara, F.2    Osaki, N.3    Shimotoyodome, A.4
  • 207
    • 84882629237 scopus 로고    scopus 로고
    • High fat diet accelerates pathogenesis of murine Crohn's disease-like ileitis independently of obesity
    • Gruber L, Kisling S, Lichti P, Martin FP, May S, Klingenspor M, et al. High fat diet accelerates pathogenesis of murine Crohn's disease-like ileitis independently of obesity. PLoS One (2013) 8(8):e71661. doi:10.1371/journal.pone.0071661
    • (2013) PLoS One , vol.8 , Issue.8
    • Gruber, L.1    Kisling, S.2    Lichti, P.3    Martin, F.P.4    May, S.5    Klingenspor, M.6
  • 208
    • 3042739678 scopus 로고    scopus 로고
    • Lipid and carbohydrate metabolism in mice with a targeted mutation in the IL-6 gene: absence of development of age-related obesity
    • Di Gregorio GB, Hensley L, Lu T, Ranganathan G, Kern PA. Lipid and carbohydrate metabolism in mice with a targeted mutation in the IL-6 gene: absence of development of age-related obesity. Am J Physiol Endocrinol Metab (2004) 287(1):E182-7. doi:10.1152/ajpendo.00189.2003
    • (2004) Am J Physiol Endocrinol Metab , vol.287 , Issue.1 , pp. E182-E187
    • Di Gregorio, G.B.1    Hensley, L.2    Lu, T.3    Ranganathan, G.4    Kern, P.A.5
  • 209
    • 84947558943 scopus 로고    scopus 로고
    • Intestinal organoids for assessing nutrient transport, sensing and incretin secretion
    • Zietek T, Rath E, Haller D, Daniel H. Intestinal organoids for assessing nutrient transport, sensing and incretin secretion. Sci Rep (2015) 5:16831. doi:10.1038/srep16831
    • (2015) Sci Rep , vol.5 , pp. 16831
    • Zietek, T.1    Rath, E.2    Haller, D.3    Daniel, H.4


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