The unfolded protein response and chemical chaperones reduce protein misfolding and colitis in mice

Gastroenterology

Volumn 144, Issue 5, 2013, Pages

  Cao, Stewart Siyan ^a,b   Zimmermann, Ellen M ^b   Chuang, Brandy Mengchieh ^a   Song, Benbo ^c   Nwokoye, Anosike ^d   Wilkinson, J Erby ^e   Eaton, Kathryn A ^b,e   Kaufman, Randal J ^a,b  

^a BURNHAM INSTITUTE   (United States)

^b UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^c NGM Biopharmaceuticals Inc   (United States)

^d UNIVERSITY OF MICHIGAN COMPREHENSIVE CANCER CENTER   (United States)

^e UNIVERSITY OF MICHIGAN   (United States)

Author keywords

IBD; Mouse Model; Therapeutic Agent; Ulcerative Colitis

Indexed keywords

4 PHENYLBUTYRIC ACID; ACTIVATING TRANSCRIPTION FACTOR 6; CHAPERONE; DEXTRAN SULFATE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; MEMBRANE PROTEIN; PROTEIN DNAJC3; TAUROURSODEOXYCHOLIC ACID; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; CELL DEATH; COLITIS; COLON MUCOSA; CONTROLLED STUDY; DISEASE SEVERITY; ENDOPLASMIC RETICULUM STRESS; ENTERITIS; INFLAMMATORY CELL; INTESTINE EPITHELIUM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UNFOLDED PROTEIN RESPONSE; WILD TYPE;

EID: 84876486995     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2013.01.023     Document Type: Article

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