Increased GIP signaling induces adipose inflammation via a HIF-α-dependent pathway and impairs insulin sensitivity in mice

American Journal of Physiology - Endocrinology and Metabolism

Volumn 308, Issue 5, 2015, Pages E414-E425

  Chen, Shu ^a   Okahara, Fumiaki ^a   Osaki, Noriko ^a   Shimotoyodome, Akira ^a  

^a KAO CORPORATION   (Japan)

Author keywords

Adipose tissue inflammation; GIP; Hypoxia; Insulin resistance; Macrophage

Indexed keywords

COMPLEMENTARY DNA; GASTRIC INHIBITORY POLYPEPTIDE; HORMONE RECEPTOR; HUMAN INSULIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; PLASMINOGEN ACTIVATOR INHIBITOR 1; RNA; HIF1A PROTEIN, MOUSE;

ADIPOCYTE; ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DIET; GENE EXPRESSION; HYPOXIA; INFLAMMATION; INSULIN SENSITIVITY; INSULIN TOLERANCE TEST; MACROPHAGE; MALE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; 3T3 CELL LINE; ANIMAL; CELL CULTURE; DRUG EFFECTS; INSULIN RESISTANCE; METABOLISM; PATHOLOGY; PERITONEUM MACROPHAGE; PHYSIOLOGY; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; UPREGULATION;

3T3-L1 CELLS; ADIPOSE TISSUE; ANIMALS; CELLS, CULTURED; GASTRIC INHIBITORY POLYPEPTIDE; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INFLAMMATION; INSULIN RESISTANCE; MACROPHAGES, PERITONEAL; MALE; MICE; MICE, TRANSGENIC; OBESITY; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84923931916     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00418.2014     Document Type: Article

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