-
1
-
-
27544465354
-
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
-
Park H, Li Z, Yang XO, Chang SH, Nurieva R, et al. (2005) A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 6: 1133-1141.
-
(2005)
Nat Immunol
, vol.6
, pp. 1133-1141
-
-
Park, H.1
Li, Z.2
Yang, X.O.3
Chang, S.H.4
Nurieva, R.5
-
2
-
-
13244283212
-
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
-
Langrish CL, Chen Y, Blumenschein WM, Mattson J, Basham B, et al. (2005) IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med 201: 233-240.
-
(2005)
J Exp Med
, vol.201
, pp. 233-240
-
-
Langrish, C.L.1
Chen, Y.2
Blumenschein, W.M.3
Mattson, J.4
Basham, B.5
-
3
-
-
27544490377
-
Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
-
Harrington LE, Hatton RD, Mangan PR, Turner H, Murphy TL, et al. (2005) Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 6: 1123-1132.
-
(2005)
Nat Immunol
, vol.6
, pp. 1123-1132
-
-
Harrington, L.E.1
Hatton, R.D.2
Mangan, P.R.3
Turner, H.4
Murphy, T.L.5
-
4
-
-
77955096184
-
Therapeutic targets in rheumatoid arthritis: The interleukin-6 receptor
-
Dayer JM, Choy E (2010) Therapeutic targets in rheumatoid arthritis: the interleukin-6 receptor. Rheumatology (Oxford) 49: 15-24.
-
(2010)
Rheumatology (Oxford)
, vol.49
, pp. 15-24
-
-
Dayer, J.M.1
Choy, E.2
-
5
-
-
40749114497
-
Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): A double-blind, placebo-controlled, randomised trial
-
Smolen JS, Beaulieu A, Rubbert-Roth A, Ramos-Remus C, Rovensky J, et al. (2008) Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial. Lancet 371: 987-997.
-
(2008)
Lancet
, vol.371
, pp. 987-997
-
-
Smolen, J.S.1
Beaulieu, A.2
Rubbert-Roth, A.3
Ramos-Remus, C.4
Rovensky, J.5
-
6
-
-
79953680176
-
Tocilizumab inhibits structural joint damage in rheumatoid arthritis patients with inadequate responses to methotrexate: Results from the double-blind treatment phase of a randomized placebo-controlled trial of tocilizumab safety and prevention of structural joint damage at one year
-
Kremer JM, Blanco R, Brzosko M, Burgos-Vargas R, Halland AM, et al. (2011) Tocilizumab inhibits structural joint damage in rheumatoid arthritis patients with inadequate responses to methotrexate: results from the double-blind treatment phase of a randomized placebo-controlled trial of tocilizumab safety and prevention of structural joint damage at one year. Arthritis Rheum 63: 609-621.
-
(2011)
Arthritis Rheum
, vol.63
, pp. 609-621
-
-
Kremer, J.M.1
Blanco, R.2
Brzosko, M.3
Burgos-Vargas, R.4
Halland, A.M.5
-
7
-
-
52149099504
-
IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to antitumour necrosis factor biologicals: Results from a 24-week multicentre randomised placebo-controlled trial
-
Emery P, Keystone E, Tony HP, Cantagrel A, van Vollenhoven R, et al. (2008) IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to antitumour necrosis factor biologicals: results from a 24-week multicentre randomised placebo-controlled trial. Ann Rheum Dis 67: 1516-1523.
-
(2008)
Ann Rheum Dis
, vol.67
, pp. 1516-1523
-
-
Emery, P.1
Keystone, E.2
Tony, H.P.3
Cantagrel, A.4
Van Vollenhoven, R.5
-
8
-
-
80755182205
-
Lower gastrointestinal perforation in rheumatoid arthritis patients treated with conventional DMARDs or tocilizumab: A systematic literature review
-
Gout T, Ostor AJ, Nisar MK (2011) Lower gastrointestinal perforation in rheumatoid arthritis patients treated with conventional DMARDs or tocilizumab: a systematic literature review. Clin Rheumatol 30: 1471-1474.
-
(2011)
Clin Rheumatol
, vol.30
, pp. 1471-1474
-
-
Gout, T.1
Ostor, A.J.2
Nisar, M.K.3
-
9
-
-
11144358366
-
A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn's disease
-
discussion 947
-
Ito H, Takazoe M, Fukuda Y, Hibi T, Kusugami K, et al. (2004) A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn's disease. Gastroenterology 126: 989-996; discussion 947.
-
(2004)
Gastroenterology
, vol.126
, pp. 989-996
-
-
Ito, H.1
Takazoe, M.2
Fukuda, Y.3
Hibi, T.4
Kusugami, K.5
-
10
-
-
84896495700
-
Master regulator of intestinal disease: IL-6 in chronic inflammation and cancer development
-
Waldner MJ, Neurath MF (2014) Master regulator of intestinal disease: IL-6 in chronic inflammation and cancer development. Semin Immunol 26: 75-79.
-
(2014)
Semin Immunol
, vol.26
, pp. 75-79
-
-
Waldner, M.J.1
Neurath, M.F.2
-
11
-
-
34548190038
-
Il-6 signaling in inflammatory bowel disease: Pathophysiological role and clinical relevance
-
Mudter J, Neurath MF (2007) Il-6 signaling in inflammatory bowel disease: pathophysiological role and clinical relevance. Inflamm Bowel Dis 13: 1016-1023.
-
(2007)
Inflamm Bowel Dis
, vol.13
, pp. 1016-1023
-
-
Mudter, J.1
Neurath, M.F.2
-
12
-
-
0033179725
-
Clinical relevance of serum interleukin-6 in Crohn's disease: Single point measurements, therapy monitoring, and prediction of clinical relapse
-
Reinisch W, Gasche C, Tillinger W, Wyatt J, Lichtenberger C, et al. (1999) Clinical relevance of serum interleukin-6 in Crohn's disease: single point measurements, therapy monitoring, and prediction of clinical relapse. Am J Gastroenterol 94: 2156-2164.
-
(1999)
Am J Gastroenterol
, vol.94
, pp. 2156-2164
-
-
Reinisch, W.1
Gasche, C.2
Tillinger, W.3
Wyatt, J.4
Lichtenberger, C.5
-
13
-
-
58649101347
-
gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis
-
Bollrath J, Phesse TJ, von Burstin VA, Putoczki T, Bennecke M, et al. (2009) gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis. Cancer Cell 15: 91-102.
-
(2009)
Cancer Cell
, vol.15
, pp. 91-102
-
-
Bollrath, J.1
Phesse, T.J.2
Von Burstin, V.A.3
Putoczki, T.4
Bennecke, M.5
-
14
-
-
58649108302
-
IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer
-
Grivennikov S, Karin E, Terzic J, Mucida D, Yu GY, et al. (2009) IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell 15: 103-113.
-
(2009)
Cancer Cell
, vol.15
, pp. 103-113
-
-
Grivennikov, S.1
Karin, E.2
Terzic, J.3
Mucida, D.4
Yu, G.Y.5
-
15
-
-
45549097533
-
IL-6-dependent mucosal protection prevents establishment of a microbial niche for attaching/effacing lesion-forming enteric bacterial pathogens
-
Dann SM, Spehlmann ME, Hammond DC, Iimura M, Hase K, et al. (2008) IL-6-dependent mucosal protection prevents establishment of a microbial niche for attaching/effacing lesion-forming enteric bacterial pathogens. J Immunol 180: 6816-6826.
-
(2008)
J Immunol
, vol.180
, pp. 6816-6826
-
-
Dann, S.M.1
Spehlmann, M.E.2
Hammond, D.C.3
Iimura, M.4
Hase, K.5
-
16
-
-
84867198093
-
Wnt5a potentiates TGF-beta signaling to promote colonic crypt regeneration after tissue injury
-
Miyoshi H, Ajima R, Luo CT, Yamaguchi TP, Stappenbeck TS (2012) Wnt5a potentiates TGF-beta signaling to promote colonic crypt regeneration after tissue injury. Science 338: 108-113.
-
(2012)
Science
, vol.338
, pp. 108-113
-
-
Miyoshi, H.1
Ajima, R.2
Luo, C.T.3
Yamaguchi, T.P.4
Stappenbeck, T.S.5
-
17
-
-
41549111071
-
An antibiotic-responsive mouse model of fulminant ulcerative colitis
-
Kang SS, Bloom SM, Norian LA, Geske MJ, Flavell RA, et al. (2008) An antibiotic-responsive mouse model of fulminant ulcerative colitis. PLoS Med 5: e41.
-
(2008)
PLoS Med
, vol.5
, pp. e41
-
-
Kang, S.S.1
Bloom, S.M.2
Norian, L.A.3
Geske, M.J.4
Flavell, R.A.5
-
18
-
-
79956078164
-
Commensal Bacteroides species induce colitis in host-genotype-specific fashion in a mouse model of inflammatory bowel disease
-
Bloom S, Bijanki V, Nava G, Sun L, Malvin N, et al. (2011) Commensal Bacteroides species induce colitis in host-genotype-specific fashion in a mouse model of inflammatory bowel disease. Cell host & microbe 9: 390-793.
-
(2011)
Cell Host & Microbe
, vol.9
, pp. 390-793
-
-
Bloom, S.1
Bijanki, V.2
Nava, G.3
Sun, L.4
Malvin, N.5
-
19
-
-
0025610846
-
Anti-IL-6 monoclonal antibodies protect against lethal Escherichia coli infection and lethal tumor necrosis factor-alpha challenge in mice
-
Starnes HF Jr, Pearce MK, Tewari A, Yim JH, Zou JC, et al. (1990) Anti-IL-6 monoclonal antibodies protect against lethal Escherichia coli infection and lethal tumor necrosis factor-alpha challenge in mice. J Immunol 145: 4185-4191.
-
(1990)
J Immunol
, vol.145
, pp. 4185-4191
-
-
Starnes, H.F.1
Pearce, M.K.2
Tewari, A.3
Yim, J.H.4
Zou, J.C.5
-
20
-
-
84862732998
-
Igf2bp1 is required for full induction of Ptgs2 mRNA in colonic mesenchymal stem cells in mice
-
e110
-
Manieri NA, Drylewicz MR, Miyoshi H, Stappenbeck TS (2012) Igf2bp1 is required for full induction of Ptgs2 mRNA in colonic mesenchymal stem cells in mice. Gastroenterology 143: 110-121 e110.
-
(2012)
Gastroenterology
, vol.143
, pp. 110-121
-
-
Manieri, N.A.1
Drylewicz, M.R.2
Miyoshi, H.3
Stappenbeck, T.S.4
-
21
-
-
58549094584
-
Efficient colonic mucosal wound repair requires Trem2 signaling
-
Seno H, Miyoshi H, Brown SL, Geske MJ, Colonna M, et al. (2009) Efficient colonic mucosal wound repair requires Trem2 signaling. Proc Natl Acad Sci U S A 106: 256-261.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 256-261
-
-
Seno, H.1
Miyoshi, H.2
Brown, S.L.3
Geske, M.J.4
Colonna, M.5
-
22
-
-
77949326158
-
Essential roles of IL-6 trans-signaling in colonic epithelial cells, induced by the IL-6/soluble-IL-6 receptor derived from lamina propria macrophages, on the development of colitis-associated premalignant cancer in a murine model
-
Matsumoto S, Hara T, Mitsuyama K, Yamamoto M, Tsuruta O, et al. (2010) Essential roles of IL-6 trans-signaling in colonic epithelial cells, induced by the IL-6/soluble-IL-6 receptor derived from lamina propria macrophages, on the development of colitis-associated premalignant cancer in a murine model. J Immunol 184: 1543-1551.
-
(2010)
J Immunol
, vol.184
, pp. 1543-1551
-
-
Matsumoto, S.1
Hara, T.2
Mitsuyama, K.3
Yamamoto, M.4
Tsuruta, O.5
-
23
-
-
10044264634
-
Pivotal roles of interleukin-6 in transmural inflammation in murine T cell transfer colitis
-
Kitamura K, Nakamoto Y, Kaneko S, Mukaida N (2004) Pivotal roles of interleukin-6 in transmural inflammation in murine T cell transfer colitis. J Leukoc Biol 76: 1111-1117.
-
(2004)
J Leukoc Biol
, vol.76
, pp. 1111-1117
-
-
Kitamura, K.1
Nakamoto, Y.2
Kaneko, S.3
Mukaida, N.4
-
24
-
-
5644252874
-
TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling
-
Becker C, Fantini MC, Schramm C, Lehr HA, Wirtz S, et al. (2004) TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling. Immunity 21: 491-501.
-
(2004)
Immunity
, vol.21
, pp. 491-501
-
-
Becker, C.1
Fantini, M.C.2
Schramm, C.3
Lehr, H.A.4
Wirtz, S.5
-
25
-
-
0042209597
-
Serum interleukin-6 levels reflect the disease status of colorectal cancer
-
Chung YC, Chang YF (2003) Serum interleukin-6 levels reflect the disease status of colorectal cancer. J Surg Oncol 83: 222-226.
-
(2003)
J Surg Oncol
, vol.83
, pp. 222-226
-
-
Chung, Y.C.1
Chang, Y.F.2
-
26
-
-
0036176551
-
Prognostic significance of circulating IL-10 and IL-6 serum levels in colon cancer patients undergoing surgery
-
Galizia G, Orditura M, Romano C, Lieto E, Castellano P, et al. (2002) Prognostic significance of circulating IL-10 and IL-6 serum levels in colon cancer patients undergoing surgery. Clin Immunol 102: 169-178.
-
(2002)
Clin Immunol
, vol.102
, pp. 169-178
-
-
Galizia, G.1
Orditura, M.2
Romano, C.3
Lieto, E.4
Castellano, P.5
-
27
-
-
0034599429
-
Interleukin-6 stimulates clonogenic growth of primary and metastatic human colon carcinoma cells
-
Schneider MR, Hoeflich A, Fischer JR, Wolf E, Sordat B, et al. (2000) Interleukin-6 stimulates clonogenic growth of primary and metastatic human colon carcinoma cells. Cancer Lett 151: 31-38.
-
(2000)
Cancer Lett
, vol.151
, pp. 31-38
-
-
Schneider, M.R.1
Hoeflich, A.2
Fischer, J.R.3
Wolf, E.4
Sordat, B.5
-
28
-
-
0028328436
-
Impaired immune and acute-phase responses in interleukin-6-deficient mice
-
Kopf M, Baumann H, Freer G, Freudenberg M, Lamers M, et al. (1994) Impaired immune and acute-phase responses in interleukin-6-deficient mice. Nature 368: 339-342.
-
(1994)
Nature
, vol.368
, pp. 339-342
-
-
Kopf, M.1
Baumann, H.2
Freer, G.3
Freudenberg, M.4
Lamers, M.5
-
29
-
-
0026745023
-
Long-term consequences of interleukin-6 overexpression in transgenic mice
-
Woodroofe C, Muller W, Ruther U (1992) Long-term consequences of interleukin-6 overexpression in transgenic mice. DNA Cell Biol 11: 587-592.
-
(1992)
DNA Cell Biol
, vol.11
, pp. 587-592
-
-
Woodroofe, C.1
Muller, W.2
Ruther, U.3
-
30
-
-
0037022341
-
IL-6 transgenic mouse model for extraosseous plasmacytoma
-
Kovalchuk AL, Kim JS, Park SS, Coleman AE, Ward JM, et al. (2002) IL-6 transgenic mouse model for extraosseous plasmacytoma. Proc Natl Acad Sci U S A 99: 1509-1514.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 1509-1514
-
-
Kovalchuk, A.L.1
Kim, J.S.2
Park, S.S.3
Coleman, A.E.4
Ward, J.M.5
-
31
-
-
0025599882
-
Significant increase of interleukin 6 production in blood mononuclear leukocytes obtained from patients with active inflammatory bowel disease
-
Suzuki Y, Saito H, Kasanuki J, Kishimoto T, Tamura Y, et al. (1990) Significant increase of interleukin 6 production in blood mononuclear leukocytes obtained from patients with active inflammatory bowel disease. Life Sci 47: 2193-2197.
-
(1990)
Life Sci
, vol.47
, pp. 2193-2197
-
-
Suzuki, Y.1
Saito, H.2
Kasanuki, J.3
Kishimoto, T.4
Tamura, Y.5
-
32
-
-
0027451455
-
Enhanced secretion of tumour necrosis factor-alpha, IL-6, and IL-1 beta by isolated lamina propria mononuclear cells from patients with ulcerative colitis and Crohn's disease
-
Reinecker HC, Steffen M, Witthoeft T, Pflueger I, Schreiber S, et al. (1993) Enhanced secretion of tumour necrosis factor-alpha, IL-6, and IL-1 beta by isolated lamina propria mononuclear cells from patients with ulcerative colitis and Crohn's disease. Clin Exp Immunol 94: 174-181.
-
(1993)
Clin Exp Immunol
, vol.94
, pp. 174-181
-
-
Reinecker, H.C.1
Steffen, M.2
Witthoeft, T.3
Pflueger, I.4
Schreiber, S.5
-
33
-
-
0029063552
-
Differences in intraepithelial lymphocyte T cell subsets isolated from murine small versus large intestine
-
Beagley KW, Fujihashi K, Lagoo AS, Lagoo-Deenadaylan S, Black CA, et al. (1995) Differences in intraepithelial lymphocyte T cell subsets isolated from murine small versus large intestine. J Immunol 154: 5611-5619.
-
(1995)
J Immunol
, vol.154
, pp. 5611-5619
-
-
Beagley, K.W.1
Fujihashi, K.2
Lagoo, A.S.3
Lagoo-Deenadaylan, S.4
Black, C.A.5
|