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Volumn 19, Issue 10, 2013, Pages 1956-1964

Long-term etanercept therapy favors weight gain and ameliorates cachexia in rheumatoid arthritis patients: Roles of gut hormones and leptin

Author keywords

Appetite; Body weight; Cachexia; Etanercept; Ghrelin; Glucose dependent insulinotropic polypeptide (GIP); Leptin; Rheumatoid arthritis (RA)

Indexed keywords

DISEASE MODIFYING ANTIRHEUMATIC DRUG; ETANERCEPT; GASTRIC INHIBITORY POLYPEPTIDE; GASTROINTESTINAL HORMONE; GHRELIN; GLUCOSE; LEPTIN; LIPID; URIC ACID;

EID: 84876738647     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/1381612811319100014     Document Type: Article
Times cited : (47)

References (48)
  • 1
    • 0033611472 scopus 로고    scopus 로고
    • A trial of etanercept, a recombinant tumor necrosis factor receptor: Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate
    • Weinblatt ME, Kremer JM, Bankhurst AD, et al. A trial of etanercept, a recombinant tumor necrosis factor receptor: Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate. N Engl J Med 1999; 340: 253-59.
    • (1999) N Engl J Med , vol.340 , pp. 253-259
    • Weinblatt, M.E.1    Kremer, J.M.2    Bankhurst, A.D.3
  • 2
    • 80055098437 scopus 로고    scopus 로고
    • Anti-TNF treatment in rheumatoid arthritis
    • Aeiler J, Buch M, McDermott MF. Anti-TNF treatment in rheumatoid arthritis. Curr Pharm Des 2011; 17: 3141-54.
    • (2011) Curr Pharm Des , vol.17 , pp. 3141-3154
    • Aeiler, J.1    Buch, M.2    McDermott, M.F.3
  • 3
    • 67649406107 scopus 로고    scopus 로고
    • Effectiveness and safety of etanercept in subjects with RA who have failed infliximab therapy: 16-week, open-label, observational study
    • Bingham CO 3rd, Ince A, Haraoui B, et al. Effectiveness and safety of etanercept in subjects with RA who have failed infliximab therapy: 16-week, open-label, observational study. Curr Med Res Opin 2009; 5: 1131-42.
    • (2009) Curr Med Res Opin , vol.5 , pp. 1131-1142
    • Bingham III, C.O.1    Ince, A.2    Haraoui, B.3
  • 4
    • 74249115785 scopus 로고    scopus 로고
    • Improvement of active rheumatoid arthritis after etanercept injection: A single-center experience
    • Su KY, Lee HT, Chou CT, et al. Improvement of active rheumatoid arthritis after etanercept injection: a single-center experience. J Chin Med Assoc 2009; 72: 581-7.
    • (2009) J Chin Med Assoc , vol.72 , pp. 581-587
    • Su, K.Y.1    Lee, H.T.2    Chou, C.T.3
  • 5
    • 33845491244 scopus 로고    scopus 로고
    • Randomized phase 2 trial of anti-tumor necrosis factor therapy for cachexia in patients with early rheumatoid arthritis
    • Marcora SM, Chester KR, Mittal G, et al. Randomized phase 2 trial of anti-tumor necrosis factor therapy for cachexia in patients with early rheumatoid arthritis. Am J Clin Nutr 2006; 84: 1463-72.
    • (2006) Am J Clin Nutr , vol.84 , pp. 1463-1472
    • Marcora, S.M.1    Chester, K.R.2    Mittal, G.3
  • 6
    • 52949136215 scopus 로고    scopus 로고
    • Cachexia in rheumatoid arthritis is associated with inflammatory activity, physical disability, and low bioavailable insulin-like growth factor
    • Engvall IL, Elkan AC, Tengstrand B, et al. Cachexia in rheumatoid arthritis is associated with inflammatory activity, physical disability, and low bioavailable insulin-like growth factor. Scand J Rheumatol 2008; 37: 321-8.
    • (2008) Scand J Rheumatol , vol.37 , pp. 321-328
    • Engvall, I.L.1    Elkan, A.C.2    Tengstrand, B.3
  • 7
    • 0035722694 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha and muscle wasting: A cellular perspective
    • Reid MB, Li YP. Tumor necrosis factor-alpha and muscle wasting: a cellular perspective. Respir Res 2001; 2: 269-72.
    • (2001) Respir Res , vol.2 , pp. 269-272
    • Reid, M.B.1    Li, Y.P.2
  • 8
    • 0036582784 scopus 로고    scopus 로고
    • Role of growth hormone, insulin-like growth factor-I, and insulin-like growth factor binding proteins in the catabolic response to injury and infection
    • Lang CH, Frost RA. Role of growth hormone, insulin-like growth factor-I, and insulin-like growth factor binding proteins in the catabolic response to injury and infection. Curr Opin Clin Nutr Metab Care 2002; 5: 271-9.
    • (2002) Curr Opin Clin Nutr Metab Care , vol.5 , pp. 271-279
    • Lang, C.H.1    Frost, R.A.2
  • 9
    • 0029593387 scopus 로고
    • The cachexia associated with Trypanosoma cruzi acute infection in mice is attenuated by anti-TNF-alpha, but not by anti-IL-6 or anti-IFN-gamma antibodies
    • Truyens C, Torrico F, Angelo-Barrios A, et al. The cachexia associated with Trypanosoma cruzi acute infection in mice is attenuated by anti-TNF-alpha, but not by anti-IL-6 or anti-IFN-gamma antibodies. Parasite Immunol 1995; 17: 561-8.
    • (1995) Parasite Immunol , vol.17 , pp. 561-568
    • Truyens, C.1    Torrico, F.2    Angelo-Barrios, A.3
  • 10
    • 0026489608 scopus 로고
    • Rheumatoid cachexia: Depletion of lean body mass in rheumatoid arthritis. Possible association with tumor necrosis factor
    • Roubenoff R, Roubenoff RA, Ward LM, et al. Rheumatoid cachexia: depletion of lean body mass in rheumatoid arthritis. Possible association with tumor necrosis factor. J Rheumatol 1992; 19: 1505-10.
    • (1992) J Rheumatol , vol.19 , pp. 1505-1510
    • Roubenoff, R.1    Roubenoff, R.A.2    Ward, L.M.3
  • 11
    • 65449149461 scopus 로고    scopus 로고
    • Rheumatoid cachexia: A complication of rheumatoid arthritis moves into the 21st century
    • Roubenoff R. Rheumatoid cachexia: a complication of rheumatoid arthritis moves into the 21st century. Arthritis Res Ther 2009; 11: 108.
    • (2009) Arthritis Res Ther , vol.11 , pp. 108
    • Roubenoff, R.1
  • 12
    • 3242749843 scopus 로고    scopus 로고
    • Ghrelin inhibits leptin-and activation-induced proinflammatory cytokine expression by human monocytes and T cells
    • Dixit VD, Schaffer EM, Pyle RS, et al. Ghrelin inhibits leptin-and activation-induced proinflammatory cytokine expression by human monocytes and T cells. J Clin Invest 2004; 114: 57-66.
    • (2004) J Clin Invest , vol.114 , pp. 57-66
    • Dixit, V.D.1    Schaffer, E.M.2    Pyle, R.S.3
  • 13
    • 73449090824 scopus 로고    scopus 로고
    • Ghrelin gene products and the regulation of food intake and gut motility
    • Chen CY, Asakawa A, Fujimiya M, et al. Ghrelin gene products and the regulation of food intake and gut motility. Pharmacol Rev 2009; 61: 430-81.
    • (2009) Pharmacol Rev , vol.61 , pp. 430-481
    • Chen, C.Y.1    Asakawa, A.2    Fujimiya, M.3
  • 15
    • 77953110442 scopus 로고    scopus 로고
    • Chewing ability in conjunction with food intake and energy status in later life affects survival in Taiwanese with the metabolic syndrome
    • Lee MS, Huang YC, Wahlqvist ML. Chewing ability in conjunction with food intake and energy status in later life affects survival in Taiwanese with the metabolic syndrome. J Am Geriatr Soc 2010; 58: 1072-80.
    • (2010) J Am Geriatr Soc , vol.58 , pp. 1072-1080
    • Lee, M.S.1    Huang, Y.C.2    Wahlqvist, M.L.3
  • 16
    • 77956055481 scopus 로고    scopus 로고
    • 2010 rheumatoid arthritis classification criteria: An American College of Rheumatology/ European League Against Rheumatism collaborative initiative
    • Aletaha D, Neogi T, Silman AJ, et al. 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/ European League Against Rheumatism collaborative initiative. Arthritis Rheum 2010; 62: 2569-81.
    • (2010) Arthritis Rheum , vol.62 , pp. 2569-2581
    • Aletaha, D.1    Neogi, T.2    Silman, A.J.3
  • 17
    • 0028815803 scopus 로고
    • Modified disease activity scores that include twenty-eight-joint-counts: Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis
    • Prevoo ML, van't Hof MA, Kuper HH, et al. Modified disease activity scores that include twenty-eight-joint-counts: development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum 1995; 38: 44-8.
    • (1995) Arthritis Rheum , vol.38 , pp. 44-48
    • Prevoo, M.L.1    van't Hof, M.A.2    Kuper, H.H.3
  • 18
    • 0031715621 scopus 로고    scopus 로고
    • Validation of rheumatoid arthritis improvement criteria that include simplified joint counts
    • van Gestel AM, Haagsma CJ, van Riel PL. Validation of rheumatoid arthritis improvement criteria that include simplified joint counts. Arthritis Rheum 1998; 41: 1845-50.
    • (1998) Arthritis Rheum , vol.41 , pp. 1845-1850
    • van Gestel, A.M.1    Haagsma, C.J.2    van Riel, P.L.3
  • 19
    • 81155130702 scopus 로고    scopus 로고
    • Changes in postprandial gut hormones after metabolic surgery: A comparison of gastric bypass and sleeve gastrectomy
    • Lee WJ, Chen CY, Chong K, et al. Changes in postprandial gut hormones after metabolic surgery: a comparison of gastric bypass and sleeve gastrectomy. Surg Obes Relat Dis 2011; 7: 683-90.
    • (2011) Surg Obes Relat Dis , vol.7 , pp. 683-690
    • Lee, W.J.1    Chen, C.Y.2    Chong, K.3
  • 20
    • 33645472819 scopus 로고    scopus 로고
    • Effects of peanut oil consumption on appetite and food choice
    • Iyer SS, Boateng LA, Sales RL, et al. Effects of peanut oil consumption on appetite and food choice. Int J Obesity (Lond) 2006; 30: 704-10.
    • (2006) Int J Obesity (Lond) , vol.30 , pp. 704-710
    • Iyer, S.S.1    Boateng, L.A.2    Sales, R.L.3
  • 21
    • 0033963963 scopus 로고    scopus 로고
    • Reproducibility, power and validity of visual analogue scales in assessment of appetite sensations in single test meal studies
    • Flint A, Raben A, Blundell JE, et al. Reproducibility, power and validity of visual analogue scales in assessment of appetite sensations in single test meal studies. Int J Obes Relat Metab Disord 2000; 24: 38-48.
    • (2000) Int J Obes Relat Metab Disord , vol.24 , pp. 38-48
    • Flint, A.1    Raben, A.2    Blundell, J.E.3
  • 22
    • 78650411136 scopus 로고    scopus 로고
    • Cachexia as a major underestimated and unmet medical need: Facts and numbers
    • von Haehling S, Anker SD. Cachexia as a major underestimated and unmet medical need: facts and numbers. J Cachexia Sarcopenia Muscle 2010; 1: 1-5.
    • (2010) J Cachexia Sarcopenia Muscle , vol.1 , pp. 1-5
    • von Haehling, S.1    Anker, S.D.2
  • 23
    • 0034730251 scopus 로고    scopus 로고
    • NF-kappaB-induced loss of MyoD messenger RNA: Possible role in muscle decay and cachexia
    • Guttridge DC, Mayo MW, Madrid LV, et al. NF-kappaB-induced loss of MyoD messenger RNA: possible role in muscle decay and cachexia. Science 2000; 289: 2363-6.
    • (2000) Science , vol.289 , pp. 2363-2366
    • Guttridge, D.C.1    Mayo, M.W.2    Madrid, L.V.3
  • 24
    • 0347319155 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha production is associated with less body cell mass in women with rheumatoid arthritis
    • Walsmith J, Abad L, Kehayias J, et al. Tumor necrosis factor-alpha production is associated with less body cell mass in women with rheumatoid arthritis. J Rheumatol 2004; 31: 23-9.
    • (2004) J Rheumatol , vol.31 , pp. 23-29
    • Walsmith, J.1    Abad, L.2    Kehayias, J.3
  • 25
    • 36448966421 scopus 로고    scopus 로고
    • Blockade of tumour necrosis factor-alpha in rheumatoid arthritis: Effects on components of rheumatoid cachexia
    • Metsios GS, Stavropoulos-Kalinoglou A, Douglas KM, et al. Blockade of tumour necrosis factor-alpha in rheumatoid arthritis: effects on components of rheumatoid cachexia. Rheumatology (Oxford) 2007; 46: 1824-7.
    • (2007) Rheumatology (Oxford) , vol.46 , pp. 1824-1827
    • Metsios, G.S.1    Stavropoulos-Kalinoglou, A.2    Douglas, K.M.3
  • 26
    • 44349177615 scopus 로고    scopus 로고
    • Prospective assessment of body weight, body composition, and bone density changes in patients with spondyloarthropathy receiving anti-tumor necrosis factoralpha treatment
    • Briot K, Gossec L, Kolta S, et al. Prospective assessment of body weight, body composition, and bone density changes in patients with spondyloarthropathy receiving anti-tumor necrosis factoralpha treatment. J Rheumatol 2008; 35: 855-61.
    • (2008) J Rheumatol , vol.35 , pp. 855-861
    • Briot, K.1    Gossec, L.2    Kolta, S.3
  • 27
    • 8444233962 scopus 로고    scopus 로고
    • Prognostic importance of low body mass index in relation to cardiovascular mortality in rheumatoid arthritis
    • Kremers HM, Nicola PJ, Crowson CS, et al. Prognostic importance of low body mass index in relation to cardiovascular mortality in rheumatoid arthritis. Arthritis Rheum 2004; 50: 3450-7.
    • (2004) Arthritis Rheum , vol.50 , pp. 3450-3457
    • Kremers, H.M.1    Nicola, P.J.2    Crowson, C.S.3
  • 29
    • 0035195656 scopus 로고    scopus 로고
    • Increased prevalence of atherosclerosis in patients with medium term rheumatoid arthritis
    • Jonsson SW, Backman C, Johnson O, et al. Increased prevalence of atherosclerosis in patients with medium term rheumatoid arthritis. J Rheumatol 2001; 28: 2597-602.
    • (2001) J Rheumatol , vol.28 , pp. 2597-2602
    • Jonsson, S.W.1    Backman, C.2    Johnson, O.3
  • 30
    • 33745614045 scopus 로고    scopus 로고
    • Effects of anti-TNF-alpha treatment on lipid profile in patients with active rheumatoid arthritis
    • Seriolo B, Paolino S, Sulli A, et al. Effects of anti-TNF-alpha treatment on lipid profile in patients with active rheumatoid arthritis. Ann NY Acad Sci 2006; 1069: 414-9.
    • (2006) Ann NY Acad Sci , vol.1069 , pp. 414-419
    • Seriolo, B.1    Paolino, S.2    Sulli, A.3
  • 31
    • 78149475757 scopus 로고    scopus 로고
    • Beneficial effect of 1-year etanercept treatment on the lipid profile in responding patients with rheumatoid arthritis: The ETRA study
    • Jamnitski A, Visman IM, Peters MJ, et al. Beneficial effect of 1-year etanercept treatment on the lipid profile in responding patients with rheumatoid arthritis: the ETRA study. Ann Rheum Dis 2010; 69: 1929-33.
    • (2010) Ann Rheum Dis , vol.69 , pp. 1929-1933
    • Jamnitski, A.1    Visman, I.M.2    Peters, M.J.3
  • 32
    • 37649012449 scopus 로고    scopus 로고
    • Effects of anti-tumor necrosis factor therapy on lipid profile in patients with rheumatoid arthritis
    • Soubrier M, Jouanel P, Mathieu S, et al. Effects of anti-tumor necrosis factor therapy on lipid profile in patients with rheumatoid arthritis. Joint Bone Spine 2008; 75: 22-4.
    • (2008) Joint Bone Spine , vol.75 , pp. 22-24
    • Soubrier, M.1    Jouanel, P.2    Mathieu, S.3
  • 33
    • 84868678259 scopus 로고    scopus 로고
    • Serum uric acid plays a protective role for bone loss in peri-and postmenopausal women: A longitudinal study
    • Makovey J, Macara M, Chen JS, et al. Serum uric acid plays a protective role for bone loss in peri-and postmenopausal women: A longitudinal study. Bone 2013; 52: 400-6.
    • (2013) Bone , vol.52 , pp. 400-406
    • Makovey, J.1    Macara, M.2    Chen, J.S.3
  • 34
    • 80052963859 scopus 로고    scopus 로고
    • Ghrelin levels in patients with juvenile idiopathic arthritis: Relation to anti-tumor necrosis factor treatment and disease activity
    • Karagiozoglou-Lampoudi T, Trachana M, Agakidis C, et al. Ghrelin levels in patients with juvenile idiopathic arthritis: relation to anti-tumor necrosis factor treatment and disease activity. Metabolism 2011; 60: 1359-62.
    • (2011) Metabolism , vol.60 , pp. 1359-1362
    • Karagiozoglou-Lampoudi, T.1    Trachana, M.2    Agakidis, C.3
  • 35
    • 79959523521 scopus 로고    scopus 로고
    • The effect of disease activity on body composition and resting energy expenditure in patients with rheumatoid arthritis
    • Binymin K, Herrick A, Carlson G, et al. The effect of disease activity on body composition and resting energy expenditure in patients with rheumatoid arthritis. J Inflamm Res 2011; 4: 61-6.
    • (2011) J Inflamm Res , vol.4 , pp. 61-66
    • Binymin, K.1    Herrick, A.2    Carlson, G.3
  • 36
    • 54349118245 scopus 로고    scopus 로고
    • Antitumour necrosis factor alpha therapy modulates ghrelin in patients with severe rheumatoid arthritis
    • Gonzalez-Gay MA, Garcia-Unzueta MT, Berja A, et al. Antitumour necrosis factor alpha therapy modulates ghrelin in patients with severe rheumatoid arthritis. Ann Rheum Dis 2008; 67: 1644-6.
    • (2008) Ann Rheum Dis , vol.67 , pp. 1644-1646
    • Gonzalez-Gay, M.A.1    Garcia-Unzueta, M.T.2    Berja, A.3
  • 37
    • 80054848953 scopus 로고    scopus 로고
    • Systemic blockade of TNF-β does not improve insulin resistance in humans
    • Ferraz-Amaro I, Arce-Franco M, Muñiz J, et al. Systemic blockade of TNF-β does not improve insulin resistance in humans. Horm Metab Res 2011; 4 3: 801-8.
    • (2011) Horm Metab Res , vol.43 , pp. 801-808
    • Ferraz-Amaro, I.1    Arce-Franco, M.2    Muñiz, J.3
  • 39
    • 33846985961 scopus 로고    scopus 로고
    • Regulation of appetite in lean and obese adolescents after exercise: Role of acylated and desacyl ghrelin
    • Mackelvie KJ, Meneilly GS, Elahi D, et al. Regulation of appetite in lean and obese adolescents after exercise: role of acylated and desacyl ghrelin. J Clin Endocrinol Metab 2007; 92: 648-54.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 648-654
    • Mackelvie, K.J.1    Meneilly, G.S.2    Elahi, D.3
  • 40
    • 77952103770 scopus 로고    scopus 로고
    • Modulation of ingestive behavior and gastrointestinal motility by ghrelin in diabetic animals and humans
    • Chen CY, Fujimiya M, Laviano A, et al. Modulation of ingestive behavior and gastrointestinal motility by ghrelin in diabetic animals and humans. J Chin Med Assoc 2010; 73: 225-9.
    • (2010) J Chin Med Assoc , vol.73 , pp. 225-229
    • Chen, C.Y.1    Fujimiya, M.2    Laviano, A.3
  • 41
    • 84861646378 scopus 로고    scopus 로고
    • Ghrelin and motilin in the gastrointestinal system
    • Chen CY, Tsai CY. Ghrelin and motilin in the gastrointestinal system. Curr Pharm Des 2012; 18: 4755-65.
    • (2012) Curr Pharm Des , vol.18 , pp. 4755-4765
    • Chen, C.Y.1    Tsai, C.Y.2
  • 42
    • 79951727605 scopus 로고    scopus 로고
    • GIP and bariatric surgery
    • Rao RS, Kini S. GIP and bariatric surgery. Obes Surg 2011; 21: 244-52.
    • (2011) Obes Surg , vol.21 , pp. 244-252
    • Rao, R.S.1    Kini, S.2
  • 43
    • 67650340423 scopus 로고    scopus 로고
    • Effects of peripheral administration of synthetic human glucose-dependent insulinotropic peptide (GIP) on energy expenditure and subjective appetite sensations in healthy normal weight subjects and obese patients with type 2 diabetes
    • Daousi C, Wilding JP, Aditya S, et al. Effects of peripheral administration of synthetic human glucose-dependent insulinotropic peptide (GIP) on energy expenditure and subjective appetite sensations in healthy normal weight subjects and obese patients with type 2 diabetes. Clin Endocrinol 2009; 71: 195-201.
    • (2009) Clin Endocrinol , vol.71 , pp. 195-201
    • Daousi, C.1    Wilding, J.P.2    Aditya, S.3
  • 44
    • 70349763615 scopus 로고    scopus 로고
    • Hormonal evaluation following laparoscopic treatment of type 2 diabetes mellitus patients with BMI 20-34
    • DePaula AL, Macedo AL, Schraibman V, et al. Hormonal evaluation following laparoscopic treatment of type 2 diabetes mellitus patients with BMI 20-34. Surg Endosc 2009; 23: 1724-32.
    • (2009) Surg Endosc , vol.23 , pp. 1724-1732
    • DePaula, A.L.1    Macedo, A.L.2    Schraibman, V.3
  • 45
    • 33745728464 scopus 로고    scopus 로고
    • No change of serum levels of leptin and adiponectin during anti-tumour necrosis factor antibody treatment with adalimumab in patients with rheumatoid arthritis
    • Härle P, Sarzi-Puttini P, Cutolo M, et al. No change of serum levels of leptin and adiponectin during anti-tumour necrosis factor antibody treatment with adalimumab in patients with rheumatoid arthritis. Ann Rheum Dis 2006; 65: 970-1.
    • (2006) Ann Rheum Dis , vol.65 , pp. 970-971
    • Härle, P.1    Sarzi-Puttini, P.2    Cutolo, M.3
  • 46
    • 66149104713 scopus 로고    scopus 로고
    • Circulating leptin and adiponectin concentrations during tumor necrosis factor blockade in patients with active rheumatoid arthritis
    • Popa C, Netea MG, de Graaf J, et al. Circulating leptin and adiponectin concentrations during tumor necrosis factor blockade in patients with active rheumatoid arthritis. J Rheumatol 2009; 36: 724-30.
    • (2009) J Rheumatol , vol.36 , pp. 724-730
    • Popa, C.1    Netea, M.G.2    de Graaf, J.3
  • 47
    • 69949166663 scopus 로고    scopus 로고
    • Effects of a 6-month infliximab treatment on plasma levels of leptin and adiponectin in patients with rheumatoid arthritis
    • Derdemezis CS, Filippatos TD, Voulgari PV, et al. Effects of a 6-month infliximab treatment on plasma levels of leptin and adiponectin in patients with rheumatoid arthritis. Fundam Clin Pharmacol 2009; 23: 595-600.
    • (2009) Fundam Clin Pharmacol , vol.23 , pp. 595-600
    • Derdemezis, C.S.1    Filippatos, T.D.2    Voulgari, P.V.3
  • 48
    • 33750283745 scopus 로고    scopus 로고
    • Serum leptin levels in rheumatoid arthritis and relationship with disease activity
    • Gunaydin R, Kaya T, Atay A, et al. Serum leptin levels in rheumatoid arthritis and relationship with disease activity. South Med J 2006; 99: 1078-83.
    • (2006) South Med J , vol.99 , pp. 1078-1083
    • Gunaydin, R.1    Kaya, T.2    Atay, A.3


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