Gliptin and GLP‐1 analog treatment improves survival and vascular inflammation/dysfunction in animals with lipopolysaccharide‐induced endotoxemia

Basic Research in Cardiology

Volumn 110, Issue 2, 2015, Pages

  Steven, Sebastian ^a   Hausding, Michael ^a   Kröller Schön, Swenja ^a   Mader, Michael ^a   Mikhed, Yuliya ^a   Stamm, Paul ^a   Zinßius, Elena ^a   Pfeffer, Amanda ^a   Welschof, Philipp ^a   Agdauletova, Saule ^a   Sudowe, Stephan ^a   Li, Huige ^a   Oelze, Matthias ^a   Schulz, Eberhard ^a   Klein, Thomas ^b   Münzel, Thomas ^a   Daiber, Andreas ^a  

^a UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^b BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

Author keywords

Clinical sepsis; DPP 4 inhibitors; Endothelial dysfunction; Endotoxic shock; GLP 1 analogs; Hemostasis; Inflammation; Lipopolysaccharide induced endotoxemia; Oxidative stress

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; DIPEPTIDYL PEPTIDASE IV INHIBITOR; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; GLUCAGON LIKE PEPTIDE 1 DERIVATIVE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; LINAGLIPTIN; LIRAGLUTIDE; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; REACTIVE OXYGEN METABOLITE; SITAGLIPTIN; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1; GLUCAGON LIKE PEPTIDE 1; LIPOPOLYSACCHARIDE; PURINE DERIVATIVE; PYRAZINE DERIVATIVE; QUINAZOLINE DERIVATIVE; TRIAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLEEDING TIME; BONE MARROW DERIVED DENDRITIC CELL; CONTROLLED STUDY; GENE EXPRESSION; HEART PROTECTION; HYPOTENSION; KNOCKOUT MOUSE; LIPOPOLYSACCHARIDE-INDUCED ENDOTOXEMIA; MALE; MORTALITY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PARTIAL THROMBOPLASTIN TIME; PROTEIN EXPRESSION; SALMONELLA ENTERICA SUBSP. ENTERICA SEROVAR TYPHI; SEPTIC SHOCK; SURVIVAL RATE; ANALOGS AND DERIVATIVES; ANIMAL; C57BL MOUSE; DISEASE MODEL; DRUG EFFECTS; ENDOTOXEMIA; INFLAMMATION; PATHOPHYSIOLOGY; RAT; REAL TIME POLYMERASE CHAIN REACTION; WISTAR RAT;

ANIMALS; DIPEPTIDYL-PEPTIDASE IV INHIBITORS; DISEASE MODELS, ANIMAL; ENDOTOXEMIA; GLUCAGON-LIKE PEPTIDE 1; INFLAMMATION; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OXIDATIVE STRESS; PURINES; PYRAZINES; QUINAZOLINES; RATS; RATS, WISTAR; REAL-TIME POLYMERASE CHAIN REACTION; TRIAZOLES;

EID: 84928244016     PISSN: 03008428     EISSN: 14351803     Source Type: Journal    
DOI: 10.1007/s00395-015-0465-x     Document Type: Article

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