메뉴 건너뛰기




Volumn 20, Issue 4, 2014, Pages 671-684

Colonic expression of the peptide transporter PEPT1 is downregulated during intestinal inflammation and is not required for NOD2-dependent immune activation

Author keywords

IBD; PEPT1; Peptide transporter; Risk factor; SLC15A1

Indexed keywords

BETA ACTIN; CASPASE RECRUITMENT DOMAIN PROTEIN 15; DEXTRAN SULFATE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; PEPTIDE TRANSPORTER 1; TRINITROBENZENESULFONIC ACID; TUMOR NECROSIS FACTOR ALPHA; VILLIN; COTRANSPORTER; CYTOKINE; MESSENGER RNA; N ACETYLMURAMYLALANYL DEXTRO ISOGLUTAMINE;

EID: 84898759705     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1097/01.MIB.0000443336.71488.08     Document Type: Article
Times cited : (21)

References (50)
  • 1
    • 0028333611 scopus 로고
    • Expression cloning of a mammalian proton-coupled oligopeptide transporter
    • Fei YJ, Kanai Y, Nussberger S, et al. Expression cloning of a mammalian proton-coupled oligopeptide transporter. Nature. 1994;368:563-566.
    • (1994) Nature. , vol.368 , pp. 563-566
    • Fei, Y.J.1    Kanai, Y.2    Nussberger, S.3
  • 2
    • 84879584539 scopus 로고    scopus 로고
    • The peptide transporter PEPT1 is expressed in distal colon in rodents and humans and contributes to water absorption
    • Wuensch T, Schulz S, Ullrich S, et al. The peptide transporter PEPT1 is expressed in distal colon in rodents and humans and contributes to water absorption. Am J Physiol Gastrointest Liver Physiol. 2013;305:G66-73.
    • (2013) Am J Physiol Gastrointest Liver Physiol. , vol.305
    • Wuensch, T.1    Schulz, S.2    Ullrich, S.3
  • 3
    • 77957000911 scopus 로고    scopus 로고
    • PepT1 mediates transport of the proinflammatory bacterial tripeptide L-Ala-{gamma}-DGlu- meso-DAP in intestinal epithelial cells
    • Dalmasso G, Nguyen HT, Charrier-Hisamuddin L, et al. PepT1 mediates transport of the proinflammatory bacterial tripeptide L-Ala-{gamma}-DGlu- meso-DAP in intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2010;299:G687-G696.
    • (2010) Am J Physiol Gastrointest Liver Physiol. , vol.299
    • Dalmasso, G.1    Nguyen, H.T.2    Charrier-Hisamuddin, L.3
  • 4
    • 0032435805 scopus 로고    scopus 로고
    • HPepT1-mediated epithelial transport of bacteria-derived chemotactic peptides enhances neutrophilepithelial interactions
    • Merlin D, Steel A, Gewirtz AT, et al. hPepT1-mediated epithelial transport of bacteria-derived chemotactic peptides enhances neutrophilepithelial interactions. J Clin Invest. 1998;102:2011-2018.
    • (1998) J Clin Invest. , vol.102 , pp. 2011-2018
    • Merlin, D.1    Steel, A.2    Gewirtz, A.T.3
  • 5
    • 7644234401 scopus 로고    scopus 로고
    • HPepT1 transports muramyl dipeptide, activating NF-kappaB and stimulating IL-8 secretion in human colonic Caco2/bbe cells
    • Vavricka SR, Musch MW, Chang JE, et al. hPepT1 transports muramyl dipeptide, activating NF-kappaB and stimulating IL-8 secretion in human colonic Caco2/bbe cells. Gastroenterology. 2004;127:1401-1409.
    • (2004) Gastroenterology. , vol.127 , pp. 1401-1409
    • Vavricka, S.R.1    Musch, M.W.2    Chang, J.E.3
  • 6
    • 0027930440 scopus 로고
    • Interferon-gamma induces a cell surface phenotype switch on T84 intestinal epithelial cells
    • Colgan SP, Parkos CA, Matthews JB, et al. Interferon-gamma induces a cell surface phenotype switch on T84 intestinal epithelial cells. Am J Physiol. 1994;267:C402-C410.
    • (1994) Am J Physiol. , vol.267
    • Colgan, S.P.1    Parkos, C.A.2    Matthews, J.B.3
  • 7
    • 70349092762 scopus 로고    scopus 로고
    • Changes in mRNA expression levels of solute carrier transporters in inflammatory bowel disease patients
    • Wojtal KA, Eloranta JJ, Hruz P, et al. Changes in mRNA expression levels of solute carrier transporters in inflammatory bowel disease patients. Drug Metab Dispos. 2009;37:1871-1877.
    • (2009) Drug Metab Dispos. , vol.37 , pp. 1871-1877
    • Wojtal, K.A.1    Eloranta, J.J.2    Hruz, P.3
  • 8
    • 0035011324 scopus 로고    scopus 로고
    • Colonic epithelial hPepT1 expression occurs in inflammatory bowel disease: Transport of bacterial peptides influences expression of MHC class 1 molecules
    • Merlin D, Si-Tahar M, Sitaraman SV, et al. Colonic epithelial hPepT1 expression occurs in inflammatory bowel disease: transport of bacterial peptides influences expression of MHC class 1 molecules. Gastroenterology. 2001;120:1666-1679.
    • (2001) Gastroenterology. , vol.120 , pp. 1666-1679
    • Merlin, D.1    Si-Tahar, M.2    Sitaraman, S.V.3
  • 9
    • 77957238924 scopus 로고    scopus 로고
    • Inflammatory bowel disease: Established and evolving considerations on its etiopathogenesis and therapy
    • Schirbel A, Fiocchi C. Inflammatory bowel disease: established and evolving considerations on its etiopathogenesis and therapy. J Dig Dis. 2010;11:266-276.
    • (2010) J Dig Dis. , vol.11 , pp. 266-276
    • Schirbel, A.1    Fiocchi, C.2
  • 10
    • 0035978533 scopus 로고    scopus 로고
    • A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
    • Ogura Y, Bonen DK, Inohara N, et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature. 2001;411:603-606.
    • (2001) Nature. , vol.411 , pp. 603-606
    • Ogura, Y.1    Bonen, D.K.2    Inohara, N.3
  • 11
    • 84868336049 scopus 로고    scopus 로고
    • Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
    • Jostins L, Ripke S, Weersma RK, et al. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature. 2012;491:119-124.
    • (2012) Nature. , vol.491 , pp. 119-124
    • Jostins, L.1    Ripke, S.2    Weersma, R.K.3
  • 12
    • 70450189276 scopus 로고    scopus 로고
    • PepT1 oligopeptide transporter (SLC15A1) gene polymorphism in inflammatory bowel disease
    • Zucchelli M, Torkvist L, Bresso F, et al. PepT1 oligopeptide transporter (SLC15A1) gene polymorphism in inflammatory bowel disease. Inflamm Bowel Dis. 2009;15:1562-1569.
    • (2009) Inflamm Bowel Dis. , vol.15 , pp. 1562-1569
    • Zucchelli, M.1    Torkvist, L.2    Bresso, F.3
  • 13
    • 80053616405 scopus 로고    scopus 로고
    • The PepT1-NOD2 signaling pathway aggravates induced colitis in mice
    • Dalmasso G, Nguyen HT, Ingersoll SA, et al. The PepT1-NOD2 signaling pathway aggravates induced colitis in mice. Gastroenterology. 2011;141: 1334-1345.
    • (2011) Gastroenterology. , vol.141 , pp. 1334-1345
    • Dalmasso, G.1    Nguyen, H.T.2    Ingersoll, S.A.3
  • 14
    • 84894353884 scopus 로고    scopus 로고
    • Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: Report of a Working Party of the 2005 Montreal World Congress of Gastroenterology
    • Silverberg MS, Satsangi J, Ahmad T, et al. Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: Report of a Working Party of the 2005 Montreal World Congress of Gastroenterology. Can J Gastroenterol. 2005;19(suppl A):5-36.
    • (2005) Can J Gastroenterol. , vol.19 , Issue.SUPPL. A , pp. 5-36
    • Silverberg, M.S.1    Satsangi, J.2    Ahmad, T.3
  • 15
    • 64649096522 scopus 로고    scopus 로고
    • Targeted disruption of peptide transporter Pept1 gene in mice significantly reduces dipeptide absorption in intestine
    • Hu Y, Smith DE, Ma K, et al. Targeted disruption of peptide transporter Pept1 gene in mice significantly reduces dipeptide absorption in intestine. Mol Pharm. 2008;5:1122-1130.
    • (2008) Mol Pharm. , vol.5 , pp. 1122-1130
    • Hu, Y.1    Smith, D.E.2    Ma, K.3
  • 16
    • 79959816810 scopus 로고    scopus 로고
    • Amino acid absorption and homeostasis in mice lacking the intestinal peptide transporter PEPT1
    • Nassl AM, Rubio-Aliaga I, Fenselau H, et al. Amino acid absorption and homeostasis in mice lacking the intestinal peptide transporter PEPT1. Am J Physiol Gastrointest Liver Physiol. 2011;301:G128-G137.
    • (2011) Am J Physiol Gastrointest Liver Physiol. , vol.301
    • Nassl, A.M.1    Rubio-Aliaga, I.2    Fenselau, H.3
  • 17
    • 0027224059 scopus 로고
    • Clinicopathologic study of dextran sulfate sodium experimental murine colitis
    • Cooper HS, Murthy SN, Shah RS, et al. Clinicopathologic study of dextran sulfate sodium experimental murine colitis. Lab Invest. 1993;69:238-249.
    • (1993) Lab Invest. , vol.69 , pp. 238-249
    • Cooper, H.S.1    Murthy, S.N.2    Shah, R.S.3
  • 18
    • 14644403009 scopus 로고    scopus 로고
    • Toll-like receptor 9-induced type i IFN protects mice from experimental colitis
    • Katakura K, Lee J, Rachmilewitz D, et al. Toll-like receptor 9-induced type I IFN protects mice from experimental colitis. J Clin Invest. 2005; 115:695-702.
    • (2005) J Clin Invest. , vol.115 , pp. 695-702
    • Katakura, K.1    Lee, J.2    Rachmilewitz, D.3
  • 19
    • 0015811865 scopus 로고
    • Purification of the human intestinal brush border membrane
    • Schmitz J, Preiser H,Maestracci D, et al. Purification of the human intestinal brush border membrane. Biochim Biophys Acta. 1973;323:98-112.
    • (1973) Biochim Biophys Acta. , vol.323 , pp. 98-112
    • Schmitz, J.1    Preiser, H.2    Maestracci, D.3
  • 20
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72:248-254.
    • (1976) Anal Biochem. , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 21
    • 0033103805 scopus 로고    scopus 로고
    • Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: Implications for joint and gut-associated immunopathologies
    • Kontoyiannis D, Pasparakis M, Pizarro TT, et al. Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies. Immunity. 1999; 10:387-398.
    • (1999) Immunity. , vol.10 , pp. 387-398
    • Kontoyiannis, D.1    Pasparakis, M.2    Pizarro, T.T.3
  • 22
    • 0027521572 scopus 로고
    • Interleukin-10-deficient mice develop chronic enterocolitis
    • Kuhn R, Lohler J, Rennick D, et al. Interleukin-10-deficient mice develop chronic enterocolitis. Cell. 1993;75:263-274.
    • (1993) Cell. , vol.75 , pp. 263-274
    • Kuhn, R.1    Lohler, J.2    Rennick, D.3
  • 23
    • 0032412057 scopus 로고    scopus 로고
    • Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice
    • Sellon RK, Tonkonogy S, Schultz M, et al. Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice. Infect Immun. 1998;66:5224-5231.
    • (1998) Infect Immun. , vol.66 , pp. 5224-5231
    • Sellon, R.K.1    Tonkonogy, S.2    Schultz, M.3
  • 24
    • 80052130713 scopus 로고    scopus 로고
    • Enterococcus faecalis metalloprotease compromises epithelial barrier and contributes to intestinal inflammation
    • Steck N, Hoffmann M, Sava IG, et al. Enterococcus faecalis metalloprotease compromises epithelial barrier and contributes to intestinal inflammation. Gastroenterology. 2011;141:959-971.
    • (2011) Gastroenterology. , vol.141 , pp. 959-971
    • Steck, N.1    Hoffmann, M.2    Sava, I.G.3
  • 25
    • 70349972786 scopus 로고    scopus 로고
    • Loss of Toll-like receptor 2 and 4 leads to differential induction of endoplasmic reticulum stress and proapoptotic responses in the intestinal epithelium under conditions of chronic inflammation
    • Messlik A, Schmechel S, Kisling S, et al. Loss of Toll-like receptor 2 and 4 leads to differential induction of endoplasmic reticulum stress and proapoptotic responses in the intestinal epithelium under conditions of chronic inflammation. J Proteome Res. 2009;8:4406-4417.
    • (2009) J Proteome Res. , vol.8 , pp. 4406-4417
    • Messlik, A.1    Schmechel, S.2    Kisling, S.3
  • 26
    • 0037285726 scopus 로고    scopus 로고
    • Expression of the peptide transporter hPepT1 in human colon: A potential route for colonic protein nitrogen and drug absorption
    • Ford D, Howard A, Hirst BH. Expression of the peptide transporter hPepT1 in human colon: a potential route for colonic protein nitrogen and drug absorption. Histochem Cell Biol. 2003;119:37-43.
    • (2003) Histochem Cell Biol. , vol.119 , pp. 37-43
    • Ford, D.1    Howard, A.2    Hirst, B.H.3
  • 27
    • 0029051304 scopus 로고
    • H+/di-tripeptide transporter (PepT1) expression in the rabbit intestine
    • Freeman TC, Bentsen BS, Thwaites DT, et al. H+/di-tripeptide transporter (PepT1) expression in the rabbit intestine. Pflugers Arch. 1995;430:394-400.
    • (1995) Pflugers Arch. , vol.430 , pp. 394-400
    • Freeman, T.C.1    Bentsen, B.S.2    Thwaites, D.T.3
  • 28
    • 77957164933 scopus 로고    scopus 로고
    • Significance and regional dependency of peptide transporter (PEPT) 1 in the intestinal permeability of glycylsarcosine: In situ single-pass perfusion studies in wild-type and Pept1 knockout mice
    • Jappar D, Wu SP, Hu Y, et al. Significance and regional dependency of peptide transporter (PEPT) 1 in the intestinal permeability of glycylsarcosine: in situ single-pass perfusion studies in wild-type and Pept1 knockout mice. Drug Metab Dispos. 2010;38:1740-1746.
    • (2010) Drug Metab Dispos. , vol.38 , pp. 1740-1746
    • Jappar, D.1    Wu, S.P.2    Hu, Y.3
  • 29
    • 34047170808 scopus 로고    scopus 로고
    • Regional distribution of solute carrier mRNA expression along the human intestinal tract
    • Meier Y, Eloranta JJ, Darimont J, et al. Regional distribution of solute carrier mRNA expression along the human intestinal tract. Drug Metab Dispos. 2007;35:590-594.
    • (2007) Drug Metab Dispos. , vol.35 , pp. 590-594
    • Meier, Y.1    Eloranta, J.J.2    Darimont, J.3
  • 30
    • 0036231927 scopus 로고    scopus 로고
    • Distribution of the H+/peptide transporter PepT1 in human intestine: Up-regulated expression in the colonic mucosa of patients with short-bowel syndrome
    • Ziegler TR, Fernandez-Estivariz C, Gu LH, et al. Distribution of the H+/peptide transporter PepT1 in human intestine: up-regulated expression in the colonic mucosa of patients with short-bowel syndrome. Am J Clin Nutr. 2002;75:922-930.
    • (2002) Am J Clin Nutr. , vol.75 , pp. 922-930
    • Ziegler, T.R.1    Fernandez-Estivariz, C.2    Gu, L.H.3
  • 31
    • 0029979149 scopus 로고    scopus 로고
    • Immuno-localization of H+/peptide cotransporter in rat digestive tract
    • Ogihara H, Saito H, Shin BC, et al. Immuno-localization of H+/peptide cotransporter in rat digestive tract. Biochem Biophys Res Commun. 1996; 220:848-852.
    • (1996) Biochem Biophys Res Commun. , vol.220 , pp. 848-852
    • Ogihara, H.1    Saito, H.2    Shin, B.C.3
  • 32
    • 84884573630 scopus 로고    scopus 로고
    • Faecalibacterium prausnitzii supernatant improves intestinal barrier function in mice DSS colitis
    • Carlsson AH, Yakymenko O, Olivier I, et al. Faecalibacterium prausnitzii supernatant improves intestinal barrier function in mice DSS colitis. Scand J Gastroenterol. 2013;48:1136-1144.
    • (2013) Scand J Gastroenterol. , vol.48 , pp. 1136-1144
    • Carlsson, A.H.1    Yakymenko, O.2    Olivier, I.3
  • 33
    • 34247598857 scopus 로고    scopus 로고
    • Loss of the tight junction protein ZO-1 in dextran sulfate sodium induced colitis
    • Poritz LS, Garver KI, Green C, et al. Loss of the tight junction protein ZO-1 in dextran sulfate sodium induced colitis. J Surg Res. 2007;140:12-19.
    • (2007) J Surg Res. , vol.140 , pp. 12-19
    • Poritz, L.S.1    Garver, K.I.2    Green, C.3
  • 34
    • 66149090738 scopus 로고    scopus 로고
    • Probiotic mixture VSL#3 protects the epithelial barrier by maintaining tight junction protein expression and preventing apoptosis in a murine model of colitis
    • Mennigen R, Nolte K, Rijcken E, et al. Probiotic mixture VSL#3 protects the epithelial barrier by maintaining tight junction protein expression and preventing apoptosis in a murine model of colitis. Am J Physiol Gastrointest Liver Physiol. 2009;296:G1140-G1149.
    • (2009) Am J Physiol Gastrointest Liver Physiol. , vol.296
    • Mennigen, R.1    Nolte, K.2    Rijcken, E.3
  • 35
    • 67650667753 scopus 로고    scopus 로고
    • Temporal and spatial analysis of clinical and molecular parameters in dextran sodium sulfate induced colitis
    • Yan Y, Kolachala V, Dalmasso G, et al. Temporal and spatial analysis of clinical and molecular parameters in dextran sodium sulfate induced colitis. PLoS One. 2009;4:e6073.
    • (2009) PLoS One. , vol.4
    • Yan, Y.1    Kolachala, V.2    Dalmasso, G.3
  • 36
    • 0034697825 scopus 로고    scopus 로고
    • CDNA structure, genomic organization, and promoter analysis of the mouse intestinal peptide transporter PEPT1
    • Fei YJ, Sugawara M, Liu JC, et al. cDNA structure, genomic organization, and promoter analysis of the mouse intestinal peptide transporter PEPT1. Biochim Biophys Acta. 2000;1492:145-154.
    • (2000) Biochim Biophys Acta. , vol.1492 , pp. 145-154
    • Fei, Y.J.1    Sugawara, M.2    Liu, J.C.3
  • 38
    • 70349267549 scopus 로고    scopus 로고
    • The transmembrane tyrosines Y56, Y91 and Y167 play important roles in determining the affinity and transport rate of the rabbit proton-coupled peptide transporter PepT1
    • Pieri M, Gan C, Bailey P, et al. The transmembrane tyrosines Y56, Y91 and Y167 play important roles in determining the affinity and transport rate of the rabbit proton-coupled peptide transporter PepT1. Int J Biochem Cell Biol. 2009;41:2204-2213.
    • (2009) Int J Biochem Cell Biol. , vol.41 , pp. 2204-2213
    • Pieri, M.1    Gan, C.2    Bailey, P.3
  • 39
    • 0034674271 scopus 로고    scopus 로고
    • Functional roles of histidine and tyrosine residues in the H(+)-peptide transporter PepT1
    • Chen XZ, Steel A, Hediger MA. Functional roles of histidine and tyrosine residues in the H(+)-peptide transporter PepT1. Biochem Biophys Res Commun. 2000;272:726-730.
    • (2000) Biochem Biophys Res Commun. , vol.272 , pp. 726-730
    • Chen, X.Z.1    Steel, A.2    Hediger, M.A.3
  • 40
    • 33646858115 scopus 로고    scopus 로고
    • The oligopeptide transporter hPepT1: Gateway to the innate immune response
    • Charrier L, Merlin D. The oligopeptide transporter hPepT1: gateway to the innate immune response. Lab Invest. 2006;86:538-546.
    • (2006) Lab Invest. , vol.86 , pp. 538-546
    • Charrier, L.1    Merlin, D.2
  • 41
    • 84881037638 scopus 로고    scopus 로고
    • PepT1 expressed in immune cells has an important role in promoting the immune response during experimentally induced colitis
    • Ayyadurai S, Charania MA, Xiao B, et al. PepT1 expressed in immune cells has an important role in promoting the immune response during experimentally induced colitis. Lab Invest. 2013;93:888-899.
    • (2013) Lab Invest. , vol.93 , pp. 888-899
    • Ayyadurai, S.1    Charania, M.A.2    Xiao, B.3
  • 42
    • 23244448397 scopus 로고    scopus 로고
    • Functional expression of the peptide transporter PEPT2 in the mammalian enteric nervous system
    • Ruhl A, Hoppe S, Frey I, et al. Functional expression of the peptide transporter PEPT2 in the mammalian enteric nervous system. J Comp Neurol. 2005;490:1-11.
    • (2005) J Comp Neurol. , vol.490 , pp. 1-11
    • Ruhl, A.1    Hoppe, S.2    Frey, I.3
  • 43
    • 84875783127 scopus 로고    scopus 로고
    • Functional and molecular expression of the proton-coupled oligopeptide transporters in spleen and macrophages from mouse and human
    • Sun D, Wang Y, Tan F, et al. Functional and molecular expression of the proton-coupled oligopeptide transporters in spleen and macrophages from mouse and human. Mol Pharm. 2013;10:1409-1416.
    • (2013) Mol Pharm. , vol.10 , pp. 1409-1416
    • Sun, D.1    Wang, Y.2    Tan, F.3
  • 44
    • 0036889016 scopus 로고    scopus 로고
    • PepT1-mediated fMLP transport induces intestinal inflammation in vivo
    • Buyse M, Tsocas A, Walker F, et al. PepT1-mediated fMLP transport induces intestinal inflammation in vivo. Am J Physiol Cell Physiol. 2002;283:C1795-C1800.
    • (2002) Am J Physiol Cell Physiol. , vol.283
    • Buyse, M.1    Tsocas, A.2    Walker, F.3
  • 45
    • 33645371499 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha and interferon-gamma increase PepT1 expression and activity in the human colon carcinoma cell line Caco-2/bbe and in mouse intestine
    • Vavricka SR, Musch MW, Fujiya M, et al. Tumor necrosis factor-alpha and interferon-gamma increase PepT1 expression and activity in the human colon carcinoma cell line Caco-2/bbe and in mouse intestine. Pflugers Arch. 2006;452:71-80.
    • (2006) Pflugers Arch. , vol.452 , pp. 71-80
    • Vavricka, S.R.1    Musch, M.W.2    Fujiya, M.3
  • 46
    • 64249166480 scopus 로고    scopus 로고
    • Clathrin- and dynamindependent endocytic pathway regulates muramyl dipeptide internalization and NOD2 activation
    • Marina-Garcia N, Franchi L, Kim YG, et al. Clathrin- and dynamindependent endocytic pathway regulates muramyl dipeptide internalization and NOD2 activation. J Immunol. 2009;182:4321-4327.
    • (2009) J Immunol. , vol.182 , pp. 4321-4327
    • Marina-Garcia, N.1    Franchi, L.2    Kim, Y.G.3
  • 47
    • 0034025425 scopus 로고    scopus 로고
    • The role of the resident intestinal flora in acute and chronic dextran sulfate sodium-induced colitis in mice
    • Hans W, Scholmerich J, Gross V, et al. The role of the resident intestinal flora in acute and chronic dextran sulfate sodium-induced colitis in mice. Eur J Gastroenterol Hepatol. 2000;12:267-273.
    • (2000) Eur J Gastroenterol Hepatol. , vol.12 , pp. 267-273
    • Hans, W.1    Scholmerich, J.2    Gross, V.3
  • 48
    • 23344449020 scopus 로고    scopus 로고
    • Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiota
    • Elson CO, Cong Y, McCracken VJ, et al. Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiota. Immunol Rev. 2005;206:260-276.
    • (2005) Immunol Rev. , vol.206 , pp. 260-276
    • Elson, C.O.1    Cong, Y.2    McCracken, V.J.3
  • 49
    • 33144473772 scopus 로고    scopus 로고
    • Genetic basis for increased intestinal permeability in families with Crohn's disease: Role of CARD15 3020insC mutation?
    • Buhner S, Buning C, Genschel J, et al. Genetic basis for increased intestinal permeability in families with Crohn's disease: role of CARD15 3020insC mutation? Gut. 2006;55:342-347.
    • (2006) Gut , vol.55 , pp. 342-347
    • Buhner, S.1    Buning, C.2    Genschel, J.3
  • 50
    • 0035757522 scopus 로고    scopus 로고
    • The role of microflora in the development of intestinal inflammation: Acute and chronic colitis induced by dextran sulfate in germ-free and conventionally reared immunocompetent and immunodeficient mice
    • Hudcovic T, Stepankova R, Cebra J, et al. The role of microflora in the development of intestinal inflammation: acute and chronic colitis induced by dextran sulfate in germ-free and conventionally reared immunocompetent and immunodeficient mice. Folia Microbiol (Praha). 2001;46:565-572.
    • (2001) Folia Microbiol (Praha). , vol.46 , pp. 565-572
    • Hudcovic, T.1    Stepankova, R.2    Cebra, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.