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Volumn 14, Issue 5, 2014, Pages

Bile acid sequestrants: Glucose-lowering mechanisms and efficacy in type 2 diabetes

Author keywords

Bile acid sequestrants; Glucose lowering mechanisms; Glycemic control; Mechanism of action; Resins; Type 2 diabetes

Indexed keywords

BILE ACID; BILE ACID SEQUESTRANT; CHOLECYSTOKININ; COLESEVELAM; FARNESOID X RECEPTOR; G PROTEIN COUPLED RECEPTOR; GLUCAGON LIKE PEPTIDE 1; HEMOGLOBIN A1C; INCRETIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRANSMEMBRANE G PROTEIN COUPLED RECEPTOR TGR5; UNCLASSIFIED DRUG; ANTIDIABETIC AGENT; COLESTILAN; EPICHLOROHYDRIN; GLUCOSE BLOOD LEVEL; GLYCOSYLATED HEMOGLOBIN; HEMOGLOBIN A1C PROTEIN, HUMAN; IMIDAZOLE DERIVATIVE; RESIN;

EID: 84895775124     PISSN: 15344827     EISSN: 15390829     Source Type: Journal    
DOI: 10.1007/s11892-014-0482-4     Document Type: Review
Times cited : (48)

References (72)
  • 1
    • 58249110568 scopus 로고    scopus 로고
    • Role of bile acids and bile acid receptors in metabolic regulation
    • doi:10.1152/physrev.00010.2008
    • Lefebvre P, Cariou B, Lien F, et al. Role of bile acids and bile acid receptors in metabolic regulation. Physiol Rev. 2009;89:147-91. doi:10.1152/physrev.00010.2008.
    • (2009) Physiol Rev , vol.89 , pp. 147-191
    • Lefebvre, P.1    Cariou, B.2    Lien, F.3
  • 3
    • 13844299425 scopus 로고    scopus 로고
    • Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1
    • DOI 10.1016/j.bbrc.2005.01.139
    • Katsuma S, Hirasawa A, Tsujimoto G. Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1. Biochem Biophys Res Commun. 2005;329:386-90. doi:10.1016/j.bbrc.2005.01.139. (Pubitemid 40255465)
    • (2005) Biochemical and Biophysical Research Communications , vol.329 , Issue.1 , pp. 386-390
    • Katsuma, S.1    Hirasawa, A.2    Tsujimoto, G.3
  • 4
    • 69149083245 scopus 로고    scopus 로고
    • TGR5-mediated bile acid sensing controls glucose homeostasis
    • doi:10.1016/j.cmet.2009.08.001
    • Thomas C, Gioiello A, Noriega L, et al. TGR5-mediated bile acid sensing controls glucose homeostasis. Cell Metab. 2009;10:167-77. doi:10.1016/j.cmet. 2009.08.001.
    • (2009) Cell Metab , vol.10 , pp. 167-177
    • Thomas, C.1    Gioiello, A.2    Noriega, L.3
  • 6
    • 84855850294 scopus 로고    scopus 로고
    • Bile acid sequestrants: More than simple resins
    • doi:10.1097/MOL.0b013e32834f0ef3
    • Out C, Groen AK, Brufau G. Bile acid sequestrants: more than simple resins. Curr Opin Lipidol. 2012;23:43-55. doi:10.1097/MOL.0b013e32834f0ef3.
    • (2012) Curr Opin Lipidol , vol.23 , pp. 43-55
    • Out, C.1    Groen, A.K.2    Brufau, G.3
  • 7
    • 84864861866 scopus 로고    scopus 로고
    • Bile acid receptors as targets for the treatment of dyslipidemia and cardiovascular disease
    • doi:10.1194/jlr.R024794
    • Porez G, Prawitt J, Gross B, Staels B. Bile acid receptors as targets for the treatment of dyslipidemia and cardiovascular disease. J Lipid Res. 2012;53:1723-37. doi:10.1194/jlr.R024794.
    • (2012) J Lipid Res , vol.53 , pp. 1723-1737
    • Porez, G.1    Prawitt, J.2    Gross, B.3    Staels, B.4
  • 8
    • 0030958717 scopus 로고    scopus 로고
    • Absorption, distribution and excretion of GT31-104, a novel bile acid sequestrant, in rats and dogs after acute and subchronic administration
    • DOI 10.1021/js9603820
    • Rosenbaum DP, Petersen JS, Ducharme S, et al. Absorption, distribution and excretion of GT31-104, a novel bile acid sequestrant, in rats and dogs after acute and subchronic administration. J Pharm Sci. 1997;86:591-5. doi:10.1021/js9603820. (Pubitemid 27203407)
    • (1997) Journal of Pharmaceutical Sciences , vol.86 , Issue.5 , pp. 591-595
    • Rosenbaum, D.P.1    Petersen, J.S.2    Ducharme, S.3    Markham, P.4    Goldberg, D.I.5
  • 11
    • 0028332962 scopus 로고
    • Colestipol at varying dosage intervals in the treatment of moderate hypercholesterolaemia
    • Lyons D, Webster J, Fowler G, Petrie JC. Colestipol at varying dosage intervals in the treatment of moderate hypercholesterolaemia. Br J Clin Pharmacol. 1994;37:59-62. (Pubitemid 24204582)
    • (1994) British Journal of Clinical Pharmacology , vol.37 , Issue.1 , pp. 59-62
    • Lyons, D.1    Webster, J.2    Fowler, G.3    Petrie, J.C.4
  • 12
    • 33947120281 scopus 로고    scopus 로고
    • Results of the glucose-lowering effect of WelChol study (GLOWS): A randomized, double-blind, placebo-controlled pilot study evaluating the effect of colesevelam hydrochloride on glycemic control in subjects with type 2 diabetes
    • DOI 10.1016/j.clinthera.2007.01.003, PII S0149291807000173
    • Zieve FJ, Kalin MF, Schwartz SL, et al. Results of the glucose-lowering effect of WelChol study (GLOWS): a randomized, double-blind, placebo-controlled pilot study evaluating the effect of colesevelam hydrochloride on glycemic control in subjects with type 2 diabetes. Clin Ther. 2007;29:74-83. doi:10.1016/j.clinthera.2007.01.003. (Pubitemid 46414026)
    • (2007) Clinical Therapeutics , vol.29 , Issue.1 , pp. 74-83
    • Zieve, F.J.1    Kalin, M.F.2    Schwartz, S.L.3    Jones, M.R.4    Bailey, W.L.5
  • 13
    • 0021349709 scopus 로고
    • The Lipid Research Clinics Coronary Primary Prevention Trial results. II The relationship of reduction in incidence of coronary heart disease to cholesterol lowering
    • The Lipid Research Clinics Coronary Primary Prevention Trial results. II The relationship of reduction in incidence of coronary heart disease to cholesterol lowering. JAMA. 1984;251:365-74.
    • (1984) JAMA , vol.251 , pp. 365-374
  • 14
    • 0028575639 scopus 로고
    • Cholestyramine therapy for dyslipidemia in noninsulin-dependent diabetes mellitus. A short-term, doubleblind, crossover trial
    • Garg A, Grundy SM. Cholestyramine therapy for dyslipidemia in noninsulin-dependent diabetes mellitus. A short-term, doubleblind, crossover trial. Ann Intern Med. 1994;121:416-22.
    • (1994) Ann Intern Med , vol.121 , pp. 416-422
    • Garg, A.1    Grundy, S.M.2
  • 15
    • 54049103635 scopus 로고    scopus 로고
    • Colesevelam hydrochloride therapy in patients with type 2 diabetes mellitus treated with metformin: Glucose and lipid effects
    • doi:10.1001/archinte.168.18.1975
    • Bays HE, Goldberg RB, Truitt KE, Jones MR. Colesevelam hydrochloride therapy in patients with type 2 diabetes mellitus treated with metformin: glucose and lipid effects. Arch Intern Med. 2008;168:1975-83. doi:10.1001/archinte.168.18.1975.
    • (2008) Arch Intern Med , vol.168 , pp. 1975-1983
    • Bays, H.E.1    Goldberg, R.B.2    Truitt, K.E.3    Jones, M.R.4
  • 16
    • 49649095014 scopus 로고    scopus 로고
    • Colesevelam HCl improves glycemic control and reduces LDL cholesterol in patients with inadequately controlled type 2 diabetes on sulfonylurea-based therapy
    • doi:10.2337/dc08-0283
    • Fonseca VA, Rosenstock J, Wang AC, et al. Colesevelam HCl improves glycemic control and reduces LDL cholesterol in patients with inadequately controlled type 2 diabetes on sulfonylurea-based therapy. Diabetes Care. 2008;31:1479-84. doi:10.2337/dc08-0283.
    • (2008) Diabetes Care , vol.31 , pp. 1479-1484
    • Fonseca, V.A.1    Rosenstock, J.2    Wang, A.C.3
  • 17
    • 49449087092 scopus 로고    scopus 로고
    • Efficacy and safety of colesevelam in patients with type 2 diabetes mellitus and inadequate glycemic control receiving insulin-based therapy
    • doi:10.1001/archinte.168.14.1531
    • Goldberg RB, Fonseca VA, Truitt KE, Jones MR. Efficacy and safety of colesevelam in patients with type 2 diabetes mellitus and inadequate glycemic control receiving insulin-based therapy. Arch Intern Med. 2008;168:1531-40. doi:10.1001/archinte.168.14.1531.
    • (2008) Arch Intern Med , vol.168 , pp. 1531-1540
    • Goldberg, R.B.1    Fonseca, V.A.2    Truitt, K.E.3    Jones, M.R.4
  • 18
    • 84859057038 scopus 로고    scopus 로고
    • Hypoglycemic effects of colestimide on type 2 diabetic patients with obesity
    • Neda T, Inukai K, Kurihara S, et al. Hypoglycemic effects of colestimide on type 2 diabetic patients with obesity. Endocr J. 2012;59:239-46.
    • (2012) Endocr J , vol.59 , pp. 239-246
    • Neda, T.1    Inukai, K.2    Kurihara, S.3
  • 19
    • 84882276623 scopus 로고    scopus 로고
    • AACE comprehensive diabetes management algorithm 2013
    • Garber AJ, Abrahamson MJ, Barzilay JI, et al. AACE comprehensive diabetes management algorithm 2013. Endocr Pract. 2013;19:327-36.
    • (2013) Endocr Pract , vol.19 , pp. 327-336
    • Garber, A.J.1    Abrahamson, M.J.2    Barzilay, J.I.3
  • 20
    • 0033731362 scopus 로고    scopus 로고
    • In vitro comparison of bile acid binding to colesevelam HCl and other bile acid sequestrants
    • Braunlin W, Zhorov E, Smisek D, et al. In vitro comparison of bile acid binding to colesevelam HCl and other bile acid sequestrants. Polym Prepr. 2000;41:708-9.
    • (2000) Polym Prepr , vol.41 , pp. 708-709
    • Braunlin, W.1    Zhorov, E.2    Smisek, D.3
  • 22
    • 70450081001 scopus 로고    scopus 로고
    • Emerging Risk Factors Collaboration. Major lipids, apolipoproteins, and risk of vascular disease
    • doi:10.1001/jama.2009.1619
    • Di Angelantonio E, Sarwar N, et al. Emerging Risk Factors Collaboration. Major lipids, apolipoproteins, and risk of vascular disease. JAMA. 2009;302:1993-2000. doi:10.1001/jama.2009.1619.
    • (2009) JAMA , vol.302 , pp. 1993-2000
    • Di Angelantonio, E.1    Sarwar, N.2
  • 26
    • 0033026760 scopus 로고    scopus 로고
    • Endogenous bile acids are ligands for the nuclear receptor FXR/BAR
    • DOI 10.1016/S1097-2765(00)80348-2
    • Wang H, Chen J, Hollister K, et al. Endogenous bile acids are ligands for the nuclear receptor FXR/BAR. Mol Cell. 1999;3:543-53. (Pubitemid 29268438)
    • (1999) Molecular Cell , vol.3 , Issue.5 , pp. 543-553
    • Wang, H.1    Chen, J.2    Hollister, K.3    Sowers, L.C.4    Forman, B.M.5
  • 27
    • 0037379362 scopus 로고    scopus 로고
    • Bile salt transporters: Molecular characterization, function, and regulation
    • Trauner M, Boyer JL. Bile salt transporters: molecular characterization, function, and regulation. Physiol Rev. 2003;83:633-71. doi:10.1152/physrev. 00027.2002. (Pubitemid 36378680)
    • (2003) Physiological Reviews , vol.83 , Issue.2 , pp. 633-671
    • Trauner, M.1    Boyer, J.L.2
  • 28
    • 27844546989 scopus 로고    scopus 로고
    • Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis
    • doi:10.1016/j.cmet.2005.09.001
    • Inagaki T, Choi M, Moschetta A, et al. Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metab. 2005;2:217-25. doi:10.1016/j.cmet.2005.09.001.
    • (2005) Cell Metab , vol.2 , pp. 217-225
    • Inagaki, T.1    Choi, M.2    Moschetta, A.3
  • 29
    • 0033637121 scopus 로고    scopus 로고
    • A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis
    • Goodwin B, Jones SA, Price RR, et al. A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis. Mol Cell. 2000;6:517-26.
    • (2000) Mol Cell , vol.6 , pp. 517-526
    • Goodwin, B.1    Jones, S.A.2    Price, R.R.3
  • 30
    • 77954569180 scopus 로고    scopus 로고
    • The membrane-bound bile acid receptor TGR5 (Gpbar-1) is localized in the primary cilium of cholangiocytes
    • doi:10.1515/BC.2010.077
    • Keitel V, Ullmer C, Häussinger D. The membrane-bound bile acid receptor TGR5 (Gpbar-1) is localized in the primary cilium of cholangiocytes. Biol Chem. 2010;391:785-9. doi:10.1515/BC.2010.077.
    • (2010) Biol Chem , vol.391 , pp. 785-789
    • Keitel, V.1    Ullmer, C.2    Häussinger, D.3
  • 32
    • 33947383769 scopus 로고    scopus 로고
    • The G-protein coupled bile salt receptor TGR5 is expressed in liver sinusoidal endothelial cells
    • doi:10.1002/hep.21458
    • Keitel V, Reinehr R, Gatsios P, et al. The G-protein coupled bile salt receptor TGR5 is expressed in liver sinusoidal endothelial cells. Hepatology. 2007;45:695 - 704. doi:10.1002/hep.21458.
    • (2007) Hepatology , vol.45 , pp. 695-704
    • Keitel, V.1    Reinehr, R.2    Gatsios, P.3
  • 33
    • 84874031840 scopus 로고    scopus 로고
    • Colesevelam suppresses hepatic glycogenolysis by TGR5-mediated induction of GLP-1 action in DIO mice
    • doi:10.1152/ajpgi.00400.2012. This study establishes the concept that bile acids bound to a BAS can activate TGR5
    • • Potthoff MJ, Potts A, He T, et al. Colesevelam suppresses hepatic glycogenolysis by TGR5-mediated induction of GLP-1 action in DIO mice. Am J Physiol Gastrointest Liver Physiol. 2013;304: G371- 80. doi:10.1152/ajpgi.00400. 2012. This study establishes the concept that bile acids bound to a BAS can activate TGR5.
    • (2013) Am J Physiol Gastrointest Liver Physiol , vol.304
    • Potthoff, M.J.1    Potts, A.2    He, T.3
  • 35
    • 77953352917 scopus 로고    scopus 로고
    • Expression and function of the bile acid receptor GpBAR1 (TGR5) in the murine enteric nervous system
    • doi:10.1111/j.1365-2982.2010.01487.x
    • Poole DP, Godfrey C, Cattaruzza F, et al. Expression and function of the bile acid receptor GpBAR1 (TGR5) in the murine enteric nervous system. Neurogastroenterol Motil. 2010;22(814-25): e227-8. doi:10.1111/j.1365-2982.2010. 01487.x.
    • (2010) Neurogastroenterol Motil , vol.22
    • Poole, D.P.1    Godfrey, C.2    Cattaruzza, F.3
  • 36
    • 84871304988 scopus 로고    scopus 로고
    • The receptor TGR5 mediates the prokinetic actions of intestinal bile acids and is required for normal defecation in mice
    • doi:10.1053/j.gastro.2012.09.055
    • Alemi F, Poole DP, Chiu J, et al. The receptor TGR5 mediates the prokinetic actions of intestinal bile acids and is required for normal defecation in mice. Gastroenterology. 2013;144:145-54. doi:10.1053/j.gastro. 2012.09.055.
    • (2013) Gastroenterology , vol.144 , pp. 145-154
    • Alemi, F.1    Poole, D.P.2    Chiu, J.3
  • 37
    • 84867886430 scopus 로고    scopus 로고
    • Activation of transmembrane bile acid receptor TGR5 stimulates insulin secretion in pancreatic β cells
    • doi:10.1016/j.bbrc.2012.09.104
    • Kumar DP, Rajagopal S, Mahavadi S, et al. Activation of transmembrane bile acid receptor TGR5 stimulates insulin secretion in pancreatic β cells. Biochem Biophys Res Commun. 2012;427:600-5. doi:10.1016/j.bbrc.2012.09.104.
    • (2012) Biochem Biophys Res Commun , vol.427 , pp. 600-605
    • Kumar, D.P.1    Rajagopal, S.2    Mahavadi, S.3
  • 38
    • 0015429678 scopus 로고
    • Effect of cholestyramine on bile acid metabolism in normal man
    • doi:10.1172/JCI107100
    • Garbutt JT, Kenney TJ. Effect of cholestyramine on bile acid metabolism in normal man. J Clin Invest. 1972;51:2781-9. doi:10.1172/JCI107100.
    • (1972) J Clin Invest , vol.51 , pp. 2781-2789
    • Garbutt, J.T.1    Kenney, T.J.2
  • 39
    • 0019984161 scopus 로고
    • Hepatic uptake of bile acids in man. Fasting and postprandial concentrations of individual bile acids in portal venous and systemic blood serum
    • Angelin B, Björkhem I, Einarsson K, Ewerth S. Hepatic uptake of bile acids in man. Fasting and postprandial concentrations of individual bile acids in portal venous and systemic blood serum. J Clin Invest. 1982;70:724-31. (Pubitemid 12038088)
    • (1982) Journal of Clinical Investigation , vol.70 , Issue.4 , pp. 724-731
    • Angelin, B.1    Bjorkhem, I.2    Einarsson, K.3    Ewerth, S.4
  • 40
    • 77957960122 scopus 로고    scopus 로고
    • Improved glycemic control with colesevelam treatment in patients with type 2 diabetes is not directly associated with changes in bile acid metabolism
    • doi:10.1002/hep.23831
    • Brufau G, Stellaard F, Prado K, et al. Improved glycemic control with colesevelam treatment in patients with type 2 diabetes is not directly associated with changes in bile acid metabolism. Hepatology. 2010;52:1455-64. doi:10.1002/hep.23831.
    • (2010) Hepatology , vol.52 , pp. 1455-1464
    • Brufau, G.1    Stellaard, F.2    Prado, K.3
  • 41
    • 77956455354 scopus 로고    scopus 로고
    • Plasma bile acids are not associated with energy metabolism in humans
    • doi:10.1186/1743-7075-7-73
    • Brufau G, Bahr MJ, Staels B, et al. Plasma bile acids are not associated with energy metabolism in humans. Nutr Metab. 2010;7:73. doi:10.1186/1743-7075- 7-73.
    • (2010) Nutr Metab , vol.7 , pp. 73
    • Brufau, G.1    Bahr, M.J.2    Staels, B.3
  • 42
    • 80455126992 scopus 로고    scopus 로고
    • Bile acid sequestration reduces plasma glucose levels in db/db mice by increasing its metabolic clearance rate
    • doi:10.1371/journal.pone.0024564
    • Meissner M, Herrema H, van Dijk TH, et al. Bile acid sequestration reduces plasma glucose levels in db/db mice by increasing its metabolic clearance rate. PLoS ONE. 2011;6:e24564. doi:10.1371/journal.pone.0024564.
    • (2011) PLoS ONE , vol.6
    • Meissner, M.1    Herrema, H.2    Van Dijk, T.H.3
  • 43
    • 84876802991 scopus 로고    scopus 로고
    • Colestilan decreases weight gain by enhanced NEFA incorporation in biliary lipids and fecal lipid excretion
    • doi:10.1194/jlr.M032839
    • Sugimoto-Kawabata K, Shimada H, Sakai K, et al. Colestilan decreases weight gain by enhanced NEFA incorporation in biliary lipids and fecal lipid excretion. J Lipid Res. 2013;54:1255-64. doi:10.1194/jlr.M032839.
    • (2013) J Lipid Res , vol.54 , pp. 1255-1264
    • Sugimoto-Kawabata, K.1    Shimada, H.2    Sakai, K.3
  • 44
    • 83655161342 scopus 로고    scopus 로고
    • Effects of colesevelam on glucose absorption and hepatic/peripheral insulin sensitivity in patients with type 2 diabetes mellitus
    • doi:10.1111/j.1463-1326.2011.01486.x
    • Henry RR, Aroda VR, Mudaliar S, et al. Effects of colesevelam on glucose absorption and hepatic/peripheral insulin sensitivity in patients with type 2 diabetes mellitus. Diabetes Obes Metab. 2012;14:40-6. doi:10.1111/j.1463-1326. 2011.01486.x.
    • (2012) Diabetes Obes Metab , vol.14 , pp. 40-46
    • Henry, R.R.1    Aroda, V.R.2    Mudaliar, S.3
  • 45
    • 77950620903 scopus 로고    scopus 로고
    • The effect of colesevelam hydrochloride on insulin sensitivity and secretion in patients with type 2 diabetes: A pilot study
    • doi:10.1089/met.2009.0049
    • Schwartz SL, Lai Y-L, Xu J, et al. The effect of colesevelam hydrochloride on insulin sensitivity and secretion in patients with type 2 diabetes: a pilot study. Metab Syndr Relat Disord. 2010;8:179-88. doi:10.1089/met.2009.0049.
    • (2010) Metab Syndr Relat Disord , vol.8 , pp. 179-188
    • Schwartz, S.L.1    Lai, Y.-L.2    Xu, J.3
  • 46
    • 84875463321 scopus 로고    scopus 로고
    • The effect of a bile acid sequestrant on glucose metabolism in subjects with type 2 diabetes
    • doi:10.2337/db12-0923. This study suggests that BASs may decrease meal appearance rate
    • • Smushkin G, Sathananthan M, Piccinini F, et al. The effect of a bile acid sequestrant on glucose metabolism in subjects with type 2 diabetes. Diabetes. 2013;62:1094-101. doi:10.2337/db12-0923. This study suggests that BASs may decrease meal appearance rate.
    • (2013) Diabetes , vol.62 , pp. 1094-1101
    • Smushkin, G.1    Sathananthan, M.2    Piccinini, F.3
  • 47
    • 84856701167 scopus 로고    scopus 로고
    • Effect of bile acid sequestrants on glucose metabolism, hepatic de novo lipogenesis, and cholesterol and bile acid kinetics in type 2 diabetes: A randomized controlled study
    • doi:10.1007/s00125-011-2382-3
    • Beysen C, Murphy EJ, Deines K, et al. Effect of bile acid sequestrants on glucose metabolism, hepatic de novo lipogenesis, and cholesterol and bile acid kinetics in type 2 diabetes: a randomized controlled study. Diabetologia. 2012;55:432-42. doi:10.1007/s00125-011-2382-3.
    • (2012) Diabetologia , vol.55 , pp. 432-442
    • Beysen, C.1    Murphy, E.J.2    Deines, K.3
  • 48
    • 84866125785 scopus 로고    scopus 로고
    • Rectal taurocholate increases L cell and insulin secretion, and decreases blood glucose and food intake in obese type 2 diabetic volunteers
    • doi:10.1007/s00125-012-2593-2
    • Adrian TE, Gariballa S, Parekh KA, et al. Rectal taurocholate increases L cell and insulin secretion, and decreases blood glucose and food intake in obese type 2 diabetic volunteers. Diabetologia. 2012;55:2343-7. doi:10.1007/s00125-012-2593-2.
    • (2012) Diabetologia , vol.55 , pp. 2343-2347
    • Adrian, T.E.1    Gariballa, S.2    Parekh, K.A.3
  • 49
    • 77249142314 scopus 로고    scopus 로고
    • Colesevelam improves insulin resistance in a diet-induced obesity (F-DIO) rat model by increasing the release of GLP-1
    • doi:10.1152/ajpgi.00362.2009
    • Shang Q, Saumoy M, Holst JJ, et al. Colesevelam improves insulin resistance in a diet-induced obesity (F-DIO) rat model by increasing the release of GLP-1. Am J Physiol Gastrointest Liver Physiol. 2010;298:G419-24. doi:10.1152/ajpgi.00362.2009.
    • (2010) Am J Physiol Gastrointest Liver Physiol , vol.298
    • Shang, Q.1    Saumoy, M.2    Holst, J.J.3
  • 50
    • 84859748879 scopus 로고    scopus 로고
    • The combination of colesevelam with sitagliptin enhances glycemic control in diabetic ZDF rat model
    • doi:10.1152/ajpgi.00295.2011
    • Shang Q, Liu MK, Saumoy M, et al. The combination of colesevelam with sitagliptin enhances glycemic control in diabetic ZDF rat model. Am J Physiol Gastrointest Liver Physiol. 2012;302:G815-23. doi:10.1152/ajpgi.00295.2011.
    • (2012) Am J Physiol Gastrointest Liver Physiol , vol.302
    • Shang, Q.1    Liu, M.K.2    Saumoy, M.3
  • 51
    • 77953766726 scopus 로고    scopus 로고
    • Cholestyramine reverses hyperglycemia and enhances glucose-stimulated glucagon-like peptide 1 release in Zucker diabetic fatty rats
    • doi:10.1124/jpet.110.166892
    • Chen L, McNulty J, Anderson D, et al. Cholestyramine reverses hyperglycemia and enhances glucose-stimulated glucagon-like peptide 1 release in Zucker diabetic fatty rats. J Pharmacol Exp Ther. 2010;334:164-70. doi:10.1124/jpet.110.166892.
    • (2010) J Pharmacol Exp Ther , vol.334 , pp. 164-170
    • Chen, L.1    McNulty, J.2    Anderson, D.3
  • 52
    • 84861682490 scopus 로고    scopus 로고
    • TGR5 potentiates GLP-1 secretion in response to anionic exchange resins
    • doi:10.1038/srep00430. This study show that BASs promote GLP-1 secretion in a TGR5-dependent manner, and that the colon is the major source of the enhanced GLP-1 secretion
    • • Harach T, Pols TWH, Nomura M, et al. TGR5 potentiates GLP-1 secretion in response to anionic exchange resins. Sci Rep. 2012;2: 430. doi:10.1038/srep00430. This study show that BASs promote GLP-1 secretion in a TGR5-dependent manner, and that the colon is the major source of the enhanced GLP-1 secretion.
    • (2012) Sci Rep , vol.2 , pp. 430
    • Harach, T.1    Pols, T.W.H.2    Nomura, M.3
  • 54
    • 78650670934 scopus 로고    scopus 로고
    • Effects of colesevelam on LDL-C, A1c and GLP-1 levels in patients with type 1 diabetes: A pilot randomized double-blind trial
    • doi:10.1111/j.1463-1326.2010.01320.x
    • Garg SK, Ritchie PJ, Moser EG, et al. Effects of colesevelam on LDL-C, A1c and GLP-1 levels in patients with type 1 diabetes: a pilot randomized double-blind trial.Diabetes ObesMetab. 2011;13:137-43. doi:10.1111/j.1463-1326. 2010.01320.x.
    • (2011) Diabetes ObesMetab , vol.13 , pp. 137-143
    • Garg, S.K.1    Ritchie, P.J.2    Moser, E.G.3
  • 55
    • 84862087518 scopus 로고    scopus 로고
    • Colesevelam improves oral but not intravenous glucose tolerance by a mechanism independent of insulin sensitivity and β-cell function
    • doi:10.2337/dc11-2050. This study show that colesevelam improves oral but not IV glucose tolerance
    • • Marina AL, Utzschneider KM, Wright LA, et al. Colesevelam improves oral but not intravenous glucose tolerance by a mechanism independent of insulin sensitivity and β-cell function. Diabetes Care. 2012;35:1119-25. doi:10.2337/dc11-2050. This study show that colesevelam improves oral but not IV glucose tolerance.
    • (2012) Diabetes Care , vol.35 , pp. 1119-1125
    • Marina, A.L.1    Utzschneider, K.M.2    Wright, L.A.3
  • 56
    • 84865603263 scopus 로고    scopus 로고
    • Bile acid binding resin improves metabolic control through the induction of energy expenditure
    • doi:10.1371/journal.pone.0038286
    • Watanabe M, Morimoto K, Houten SM, et al. Bile acid binding resin improves metabolic control through the induction of energy expenditure. PLoS ONE. 2012;7:e38286. doi:10.1371/journal.pone.0038286.
    • (2012) PLoS ONE , vol.7
    • Watanabe, M.1    Morimoto, K.2    Houten, S.M.3
  • 57
    • 0033303516 scopus 로고    scopus 로고
    • Glucagon-like peptide-1-(7-36) amide is transformed to glucagon-like peptide-1-(9-36)amide by dipeptidyl peptidase IV in the capillaries supplying the L cells of the porcine intestine
    • Hansen L, Deacon CF, Orskov C, Holst JJ. Glucagon-like peptide-1-(7-36) amide is transformed to glucagon-like peptide-1-(9-36)amide by dipeptidyl peptidase IV in the capillaries supplying the L cells of the porcine intestine. Endocrinology. 1999;140:5356-63.
    • (1999) Endocrinology , vol.140 , pp. 5356-5363
    • Hansen, L.1    Deacon, C.F.2    Orskov, C.3    Holst, J.J.4
  • 58
    • 0023601883 scopus 로고
    • Feeding rats diets containing cheno- or ursodeoxycholic acid or cholestyramine modifies intestinal uptake of glucose and lipids
    • Thomson AB, Keelan M. Feeding rats diets containing cheno- or ursodeoxycholic acid or cholestyramine modifies intestinal uptake of glucose and lipids. Digestion. 1987;38:160-70. (Pubitemid 18054707)
    • (1987) Digestion , vol.38 , Issue.3 , pp. 160-170
    • Thomson, A.B.R.1    Keelan, M.2
  • 59
    • 75349109261 scopus 로고    scopus 로고
    • Effects of chenodeoxycholate and a bile acid sequestrant, colesevelam, on intestinal transit and bowel function
    • doi:10.1016/j.cgh.2009.10.020
    • Odunsi-Shiyanbade ST, Camilleri M, McKinzie S, et al. Effects of chenodeoxycholate and a bile acid sequestrant, colesevelam, on intestinal transit and bowel function. Clin Gastroenterol Hepatol. 2010;8:159-65. doi:10.1016/j.cgh.2009.10.020.
    • (2010) Clin Gastroenterol Hepatol , vol.8 , pp. 159-165
    • Odunsi-Shiyanbade, S.T.1    Camilleri, M.2    McKinzie, S.3
  • 60
    • 84870302483 scopus 로고    scopus 로고
    • Cholestyramine slows gastric emptying of liquids and reduces appetite in healthy subjects
    • doi:10.1111/j.1365-2982.2012.01988.x
    • Psichas A, Little T, Lal S, McLaughlin J. Cholestyramine slows gastric emptying of liquids and reduces appetite in healthy subjects. Neurogastroenterol Motil. 2012;24:1095-101. doi:10.1111/j.1365-2982.2012.01988.x.
    • (2012) Neurogastroenterol Motil , vol.24 , pp. 1095-1101
    • Psichas, A.1    Little, T.2    Lal, S.3    McLaughlin, J.4
  • 62
    • 77952562273 scopus 로고    scopus 로고
    • Gender-dependent effect of Gpbar1 genetic deletion on the metabolic profiles of diet-induced obese mice
    • doi:10.1677/JOE-10-0009
    • Vassileva G, Hu W, Hoos L, et al. Gender-dependent effect of Gpbar1 genetic deletion on the metabolic profiles of diet-induced obese mice. J Endocrinol. 2010;205:225-32. doi:10.1677/JOE-10-0009.
    • (2010) J Endocrinol , vol.205 , pp. 225-232
    • Vassileva, G.1    Hu, W.2    Hoos, L.3
  • 63
    • 0023751549 scopus 로고
    • Effect of cholestyramine on plasma cholecystokinin and pancreatic polypeptide levels, and exocrine pancreatic secretion
    • Koop I, Fellgiebel A, Koop H, et al. Effect of cholestyramine on plasma cholecystokinin and pancreatic polypeptide levels, and exocrine pancreatic secretion. Eur J Clin Invest. 1988;18:517-23.
    • (1988) Eur J Clin Invest , vol.18 , pp. 517-523
    • Koop, I.1    Fellgiebel, A.2    Koop, H.3
  • 64
    • 0025990502 scopus 로고
    • Dissociation of cholecystokinin and pancreaticobiliary response to intraduodenal bile acids and cholestyramine in humans
    • Koop I, Dorn S, Koop H, et al. Dissociation of cholecystokinin and pancreaticobiliary response to intraduodenal bile acids and cholestyramine in humans. Dig Dis Sci. 1991;36:1625-32.
    • (1991) Dig Dis Sci , vol.36 , pp. 1625-1632
    • Koop, I.1    Dorn, S.2    Koop, H.3
  • 65
    • 0026569478 scopus 로고
    • Chronic effect of oral cholestyramine, a bile salt sequestrant, and exogenous cholecystokinin on insulin release in rats
    • Kogire M, Gomez G, Uchida T, et al. Chronic effect of oral cholestyramine, a bile salt sequestrant, and exogenous cholecystokinin on insulin release in rats. Pancreas. 1992;7:15-20.
    • (1992) Pancreas , vol.7 , pp. 15-20
    • Kogire, M.1    Gomez, G.2    Uchida, T.3
  • 66
    • 52749098923 scopus 로고    scopus 로고
    • Gpr40 is expressed in enteroendocrine cells and mediates free fatty acid stimulation of incretin secretion
    • doi:10.2337/db08-0307
    • Edfalk S, Steneberg P, Edlund H. Gpr40 is expressed in enteroendocrine cells and mediates free fatty acid stimulation of incretin secretion. Diabetes. 2008;57:2280-7. doi:10.2337/db08-0307.
    • (2008) Diabetes , vol.57 , pp. 2280-2287
    • Edfalk, S.1    Steneberg, P.2    Edlund, H.3
  • 67
    • 79955111608 scopus 로고    scopus 로고
    • Bile acid sequestrants improve glycemic control in type 2 diabetes: A proposed mechanism implicating glucagon-like peptide 1 release
    • doi:10.1002/hep.24100
    • Hofmann AF. Bile acid sequestrants improve glycemic control in type 2 diabetes: a proposed mechanism implicating glucagon-like peptide 1 release. Hepatology. 2011;53:1784. doi:10.1002/hep.24100.
    • (2011) Hepatology , vol.53 , pp. 1784
    • Hofmann, A.F.1
  • 69
    • 0028871352 scopus 로고
    • Albuminuria and poor glycemic control predict mortality in NIDDM
    • Gall MA, Borch-Johnsen K, Hougaard P, et al. Albuminuria and poor glycemic control predict mortality in NIDDM. Diabetes. 1995;44:1303-9.
    • (1995) Diabetes , vol.44 , pp. 1303-1309
    • Gall, M.A.1    Borch-Johnsen, K.2    Hougaard, P.3
  • 70
    • 0030741927 scopus 로고    scopus 로고
    • Usefulness of microalbuminuria in predicting cardiovascular mortality in treated hypertensive men with and without diabetes mellitus
    • DOI 10.1016/S0002-9149(97)00312-3, PII S0002914997003123
    • Agewall S, Wikstrand J, Ljungman S, Fagerberg B. Usefulness of microalbuminuria in predicting cardiovascular mortality in treated hypertensive men with and without diabetes mellitus. Risk Factor Intervention Study Group. Am J Cardiol. 1997;80:164-9. (Pubitemid 27329215)
    • (1997) American Journal of Cardiology , vol.80 , Issue.2 , pp. 164-169
    • Agewall, S.1    Wikstrand, J.2    Ljungman, S.3    Fagerberg, B.4
  • 72
    • 65649106228 scopus 로고    scopus 로고
    • Effect of intensive control of glucose on cardiovascular outcomes and death in patients with diabetes mellitus: A meta-analysis of randomized controlled trials
    • doi:10.1016/S0140-6736(09)60697-8
    • Ray KK, Seshasai SRK, Wijesuriya S, et al. Effect of intensive control of glucose on cardiovascular outcomes and death in patients with diabetes mellitus: a meta-analysis of randomized controlled trials. Lancet. 2009;373:1765-72. doi:10.1016/S0140-6736(09)60697-8.
    • (2009) Lancet , vol.373 , pp. 1765-1772
    • Ray, K.K.1    Seshasai, S.R.K.2    Wijesuriya, S.3


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