메뉴 건너뛰기




Volumn 1842, Issue 9, 2014, Pages 1454-1463

Dipeptidyl peptidase-IV inhibition prevents blood-retinal barrier breakdown, inflammation and neuronal cell death in the retina of type 1 diabetic rats

Author keywords

Blood retinal barrier; Cell death; Diabetic retinopathy; Inflammation; Sitagliptin; Type 1 diabetes

Indexed keywords

CLAUDIN 5; DIPEPTIDYL PEPTIDASE IV; GLUCOSE; HEMOGLOBIN A1C; INSULIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; OCCLUDIN; PROTEIN BAX; PROTEIN ZO1; SITAGLIPTIN; STREPTOZOCIN;

EID: 84903487864     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2014.04.013     Document Type: Article
Times cited : (74)

References (55)
  • 1
    • 0036269326 scopus 로고    scopus 로고
    • The pathogenesis of diabetic retinopathy: old concepts and new questions
    • Cai J., Boulton M. The pathogenesis of diabetic retinopathy: old concepts and new questions. Eye (Lond) 2002, 16:242-260.
    • (2002) Eye (Lond) , vol.16 , pp. 242-260
    • Cai, J.1    Boulton, M.2
  • 4
    • 77957589747 scopus 로고    scopus 로고
    • Calcium dobesilate inhibits the alterations in tight junction proteins and leukocyte adhesion to retinal endothelial cells induced by diabetes
    • Leal E.C., Martins J., Voabil P., Liberal J., Chiavaroli C., Bauer J., Cunha-Vaz J., Ambrosio A.F. Calcium dobesilate inhibits the alterations in tight junction proteins and leukocyte adhesion to retinal endothelial cells induced by diabetes. Diabetes 2010, 59:2637-2645.
    • (2010) Diabetes , vol.59 , pp. 2637-2645
    • Leal, E.C.1    Martins, J.2    Voabil, P.3    Liberal, J.4    Chiavaroli, C.5    Bauer, J.6    Cunha-Vaz, J.7    Ambrosio, A.F.8
  • 5
    • 84903458803 scopus 로고    scopus 로고
    • Regulation of claudins in blood-tissue barriers under physiological and pathological states
    • Goncalves A., Ambrosio A.F., Fernandes R. Regulation of claudins in blood-tissue barriers under physiological and pathological states. Tissue Barriers 2013, 1:e24782.
    • (2013) Tissue Barriers , vol.1
    • Goncalves, A.1    Ambrosio, A.F.2    Fernandes, R.3
  • 7
    • 0033551811 scopus 로고    scopus 로고
    • Vascular endothelial growth factor induces rapid phosphorylation of tight junction proteins occludin and zonula occluden 1. A potential mechanism for vascular permeability in diabetic retinopathy and tumors
    • Antonetti D.A., Barber A.J., Hollinger L.A., Wolpert E.B., Gardner T.W. Vascular endothelial growth factor induces rapid phosphorylation of tight junction proteins occludin and zonula occluden 1. A potential mechanism for vascular permeability in diabetic retinopathy and tumors. J. Biol. Chem. 1999, 274:23463-23467.
    • (1999) J. Biol. Chem. , vol.274 , pp. 23463-23467
    • Antonetti, D.A.1    Barber, A.J.2    Hollinger, L.A.3    Wolpert, E.B.4    Gardner, T.W.5
  • 8
    • 0033771018 scopus 로고    scopus 로고
    • Altered expression of retinal occludin and glial fibrillary acidic protein in experimental diabetes
    • The Penn State Retina Research Group
    • Barber A.J., Antonetti D.A., Gardner T.W. Altered expression of retinal occludin and glial fibrillary acidic protein in experimental diabetes. Invest Ophthalmol Vis Sci 2000, 41:3561-3568. The Penn State Retina Research Group.
    • (2000) Invest Ophthalmol Vis Sci , vol.41 , pp. 3561-3568
    • Barber, A.J.1    Antonetti, D.A.2    Gardner, T.W.3
  • 9
    • 17844392902 scopus 로고    scopus 로고
    • Minocycline reduces proinflammatory cytokine expression, microglial activation, and caspase-3 activation in a rodent model of diabetic retinopathy
    • Krady J.K., Basu A., Allen C.M., Xu Y., LaNoue K.F., Gardner T.W., Levison S.W. Minocycline reduces proinflammatory cytokine expression, microglial activation, and caspase-3 activation in a rodent model of diabetic retinopathy. Diabetes 2005, 54:1559-1565.
    • (2005) Diabetes , vol.54 , pp. 1559-1565
    • Krady, J.K.1    Basu, A.2    Allen, C.M.3    Xu, Y.4    LaNoue, K.F.5    Gardner, T.W.6    Levison, S.W.7
  • 12
    • 0036517850 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs prevent early diabetic retinopathy via TNF-alpha suppression
    • Joussen A.M., Poulaki V., Mitsiades N., Kirchhof B., Koizumi K., Dohmen S., Adamis A.P. Nonsteroidal anti-inflammatory drugs prevent early diabetic retinopathy via TNF-alpha suppression. FASEB J. 2002, 16:438-440.
    • (2002) FASEB J. , vol.16 , pp. 438-440
    • Joussen, A.M.1    Poulaki, V.2    Mitsiades, N.3    Kirchhof, B.4    Koizumi, K.5    Dohmen, S.6    Adamis, A.P.7
  • 13
    • 0034531053 scopus 로고    scopus 로고
    • Effect of cyclosporin-A on the blood-retinal barrier permeability in streptozotocin-induced diabetes
    • Carmo A., Cunha-Vaz J.G., Carvalho A.P., Lopes M.C. Effect of cyclosporin-A on the blood-retinal barrier permeability in streptozotocin-induced diabetes. Mediat. Inflamm. 2000, 9:243-248.
    • (2000) Mediat. Inflamm. , vol.9 , pp. 243-248
    • Carmo, A.1    Cunha-Vaz, J.G.2    Carvalho, A.P.3    Lopes, M.C.4
  • 14
    • 33846006173 scopus 로고    scopus 로고
    • The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
    • Drucker D.J., Nauck M.A. The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet 2006, 368:1696-1705.
    • (2006) Lancet , vol.368 , pp. 1696-1705
    • Drucker, D.J.1    Nauck, M.A.2
  • 15
    • 2542479899 scopus 로고    scopus 로고
    • Minireview: glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut, and central nervous system
    • Brubaker P.L., Drucker D.J. Minireview: glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut, and central nervous system. Endocrinology 2004, 145:2653-2659.
    • (2004) Endocrinology , vol.145 , pp. 2653-2659
    • Brubaker, P.L.1    Drucker, D.J.2
  • 16
    • 0036659179 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV (CD26) on T cells cleaves the CXC chemokine CXCL11 (I-TAC) and abolishes the stimulating but not the desensitizing potential of the chemokine
    • Ludwig A., Schiemann F., Mentlein R., Lindner B., Brandt E. Dipeptidyl peptidase IV (CD26) on T cells cleaves the CXC chemokine CXCL11 (I-TAC) and abolishes the stimulating but not the desensitizing potential of the chemokine. J. Leukoc. Biol. 2002, 72:183-191.
    • (2002) J. Leukoc. Biol. , vol.72 , pp. 183-191
    • Ludwig, A.1    Schiemann, F.2    Mentlein, R.3    Lindner, B.4    Brandt, E.5
  • 17
    • 0000135759 scopus 로고    scopus 로고
    • Inhibition of dipeptidyl peptidase IV with NVP-DPP728 increases plasma GLP-1 (7-36 amide) concentrations and improves oral glucose tolerance in obese Zucker rats
    • Balkan B., Kwasnik L., Miserendino R., Holst J.J., Li X. Inhibition of dipeptidyl peptidase IV with NVP-DPP728 increases plasma GLP-1 (7-36 amide) concentrations and improves oral glucose tolerance in obese Zucker rats. Diabetologia 1999, 42:1324-1331.
    • (1999) Diabetologia , vol.42 , pp. 1324-1331
    • Balkan, B.1    Kwasnik, L.2    Miserendino, R.3    Holst, J.J.4    Li, X.5
  • 22
    • 12144260853 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 can directly protect the heart against ischemia/reperfusion injury
    • Bose A.K., Mocanu M.M., Carr R.D., Brand C.L., Yellon D.M. Glucagon-like peptide 1 can directly protect the heart against ischemia/reperfusion injury. Diabetes 2005, 54:146-151.
    • (2005) Diabetes , vol.54 , pp. 146-151
    • Bose, A.K.1    Mocanu, M.M.2    Carr, R.D.3    Brand, C.L.4    Yellon, D.M.5
  • 24
    • 79952230999 scopus 로고    scopus 로고
    • Intravitreal injection of exendin-4 analogue protects retinal cells in early diabetic rats
    • Zhang Y., Zhang J., Wang Q., Lei X., Chu Q., Xu G.T., Ye W. Intravitreal injection of exendin-4 analogue protects retinal cells in early diabetic rats. Invest. Ophthalmol. Vis. Sci. 2011, 52:278-285.
    • (2011) Invest. Ophthalmol. Vis. Sci. , vol.52 , pp. 278-285
    • Zhang, Y.1    Zhang, J.2    Wang, Q.3    Lei, X.4    Chu, Q.5    Xu, G.T.6    Ye, W.7
  • 27
    • 0029101772 scopus 로고
    • Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa B and cytokine-inducible enhancers
    • Collins T., Read M.A., Neish A.S., Whitley M.Z., Thanos D., Maniatis T. Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa B and cytokine-inducible enhancers. FASEB J. 1995, 9:899-909.
    • (1995) FASEB J. , vol.9 , pp. 899-909
    • Collins, T.1    Read, M.A.2    Neish, A.S.3    Whitley, M.Z.4    Thanos, D.5    Maniatis, T.6
  • 28
    • 0029973474 scopus 로고    scopus 로고
    • Accelerated death of retinal microvascular cells in human and experimental diabetic retinopathy
    • Mizutani M., Kern T.S., Lorenzi M. Accelerated death of retinal microvascular cells in human and experimental diabetic retinopathy. J. Clin. Invest. 1996, 97:2883-2890.
    • (1996) J. Clin. Invest. , vol.97 , pp. 2883-2890
    • Mizutani, M.1    Kern, T.S.2    Lorenzi, M.3
  • 29
    • 68149156936 scopus 로고    scopus 로고
    • The timing of re-institution of good blood glucose control affects apoptosis and expression of Bax and Bcl-2 in the retina of diabetic rats
    • Gao X.Y., Kuang H.Y., Zou W., Liu X.M., Lin H.B., Yang Y. The timing of re-institution of good blood glucose control affects apoptosis and expression of Bax and Bcl-2 in the retina of diabetic rats. Mol. Biol. Rep. 2009, 36:1977-1982.
    • (2009) Mol. Biol. Rep. , vol.36 , pp. 1977-1982
    • Gao, X.Y.1    Kuang, H.Y.2    Zou, W.3    Liu, X.M.4    Lin, H.B.5    Yang, Y.6
  • 30
    • 0030901162 scopus 로고    scopus 로고
    • Fluoro-Jade: a novel fluorochrome for the sensitive and reliable histochemical localization of neuronal degeneration
    • Schmued L.C., Albertson C., Slikker W. Fluoro-Jade: a novel fluorochrome for the sensitive and reliable histochemical localization of neuronal degeneration. Brain Res. 1997, 751:37-46.
    • (1997) Brain Res. , vol.751 , pp. 37-46
    • Schmued, L.C.1    Albertson, C.2    Slikker, W.3
  • 31
    • 61549112197 scopus 로고    scopus 로고
    • Evaluation of Fluoro-Jade C as a marker of degenerating neurons in the rat retina and optic nerve
    • Chidlow G., Wood J.P., Sarvestani G., Manavis J., Casson R.J. Evaluation of Fluoro-Jade C as a marker of degenerating neurons in the rat retina and optic nerve. Exp. Eye Res. 2009, 88:426-437.
    • (2009) Exp. Eye Res. , vol.88 , pp. 426-437
    • Chidlow, G.1    Wood, J.P.2    Sarvestani, G.3    Manavis, J.4    Casson, R.J.5
  • 32
    • 83455199245 scopus 로고    scopus 로고
    • Serum level of soluble CD26/dipeptidyl peptidase-4 (DPP-4) predicts the response to sitagliptin, a DPP-4 inhibitor, in patients with type 2 diabetes controlled inadequately by metformin and/or sulfonylurea
    • Aso Y., Ozeki N., Terasawa T., Naruse R., Hara K., Suetsugu M., Takebayashi K., Shibazaki M., Haruki K., Morita K., Inukai T. Serum level of soluble CD26/dipeptidyl peptidase-4 (DPP-4) predicts the response to sitagliptin, a DPP-4 inhibitor, in patients with type 2 diabetes controlled inadequately by metformin and/or sulfonylurea. Transl. Res. 2012, 159:25-31.
    • (2012) Transl. Res. , vol.159 , pp. 25-31
    • Aso, Y.1    Ozeki, N.2    Terasawa, T.3    Naruse, R.4    Hara, K.5    Suetsugu, M.6    Takebayashi, K.7    Shibazaki, M.8    Haruki, K.9    Morita, K.10    Inukai, T.11
  • 35
    • 84860252744 scopus 로고    scopus 로고
    • The increased dipeptidyl peptidase-4 activity is not counteracted by optimized glucose control in type 2 diabetes, but is lower in metformin-treated patients
    • Fadini G.P., Albiero M., Menegazzo L., de Kreutzenberg S.V., Avogaro A. The increased dipeptidyl peptidase-4 activity is not counteracted by optimized glucose control in type 2 diabetes, but is lower in metformin-treated patients. Diabetes Obes. Metab. 2012, 14:518-522.
    • (2012) Diabetes Obes. Metab. , vol.14 , pp. 518-522
    • Fadini, G.P.1    Albiero, M.2    Menegazzo, L.3    de Kreutzenberg, S.V.4    Avogaro, A.5
  • 36
    • 48449086945 scopus 로고    scopus 로고
    • Inhibition of dipeptidyl peptidase IV with sitagliptin (MK0431) prolongs islet graft survival in streptozotocin-induced diabetic mice
    • Kim S.J., Nian C., Doudet D.J., McIntosh C.H. Inhibition of dipeptidyl peptidase IV with sitagliptin (MK0431) prolongs islet graft survival in streptozotocin-induced diabetic mice. Diabetes 2008, 57:1331-1339.
    • (2008) Diabetes , vol.57 , pp. 1331-1339
    • Kim, S.J.1    Nian, C.2    Doudet, D.J.3    McIntosh, C.H.4
  • 38
    • 0035096388 scopus 로고    scopus 로고
    • Sensitive blood-retinal barrier breakdown quantitation using Evans blue
    • Xu Q., Qaum T., Adamis A.P. Sensitive blood-retinal barrier breakdown quantitation using Evans blue. Invest. Ophthalmol. Vis. Sci. 2001, 42:789-794.
    • (2001) Invest. Ophthalmol. Vis. Sci. , vol.42 , pp. 789-794
    • Xu, Q.1    Qaum, T.2    Adamis, A.P.3
  • 39
    • 0031737671 scopus 로고    scopus 로고
    • Vascular permeability in experimental diabetes is associated with reduced endothelial occludin content: vascular endothelial growth factor decreases occludin in retinal endothelial cells
    • Penn State Retina Research Group
    • Antonetti D.A., Barber A.J., Khin S., Lieth E., Tarbell J.M., Gardner T.W. Vascular permeability in experimental diabetes is associated with reduced endothelial occludin content: vascular endothelial growth factor decreases occludin in retinal endothelial cells. Diabetes 1998, 47:1953-1959. Penn State Retina Research Group.
    • (1998) Diabetes , vol.47 , pp. 1953-1959
    • Antonetti, D.A.1    Barber, A.J.2    Khin, S.3    Lieth, E.4    Tarbell, J.M.5    Gardner, T.W.6
  • 40
    • 0037428288 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of occludin attenuates its interactions with ZO-1, ZO-2, and ZO-3
    • Kale G., Naren A.P., Sheth P., Rao R.K. Tyrosine phosphorylation of occludin attenuates its interactions with ZO-1, ZO-2, and ZO-3. Biochem. Biophys. Res. Commun. 2003, 302:324-329.
    • (2003) Biochem. Biophys. Res. Commun. , vol.302 , pp. 324-329
    • Kale, G.1    Naren, A.P.2    Sheth, P.3    Rao, R.K.4
  • 41
    • 0029162588 scopus 로고
    • Enhanced expression of intracellular adhesion molecule-1 and P-selectin in the diabetic human retina and choroid
    • McLeod D.S., Lefer D.J., Merges C., Lutty G.A. Enhanced expression of intracellular adhesion molecule-1 and P-selectin in the diabetic human retina and choroid. Am. J. Pathol. 1995, 147:642-653.
    • (1995) Am. J. Pathol. , vol.147 , pp. 642-653
    • McLeod, D.S.1    Lefer, D.J.2    Merges, C.3    Lutty, G.A.4
  • 42
    • 84901687531 scopus 로고    scopus 로고
    • Sitagliptin prevents aggravation of endocrine and exocrine pancreatic damage in the Zucker Diabetic Fatty rat - focus on amelioration of metabolic profile and tissue cytoprotective properties
    • Mega C., Vala H., Rodrigues-Santos P., Oliveira J., Teixeira F., Fernandes R., Reis F., de Lemos E.T. Sitagliptin prevents aggravation of endocrine and exocrine pancreatic damage in the Zucker Diabetic Fatty rat - focus on amelioration of metabolic profile and tissue cytoprotective properties. Diabetol. Metab. Syndr. 2014, 6:42.
    • (2014) Diabetol. Metab. Syndr. , vol.6 , pp. 42
    • Mega, C.1    Vala, H.2    Rodrigues-Santos, P.3    Oliveira, J.4    Teixeira, F.5    Fernandes, R.6    Reis, F.7    de Lemos, E.T.8
  • 43
    • 77958195997 scopus 로고    scopus 로고
    • The oral dipeptidyl peptidase-4 inhibitor sitagliptin increases circulating endothelial progenitor cells in patients with type 2 diabetes: possible role of stromal-derived factor-1alpha
    • Fadini G.P., Boscaro E., Albiero M., Menegazzo L., Frison V., de Kreutzenberg S., Agostini C., Tiengo A., Avogaro A. The oral dipeptidyl peptidase-4 inhibitor sitagliptin increases circulating endothelial progenitor cells in patients with type 2 diabetes: possible role of stromal-derived factor-1alpha. Diabetes Care 2010, 33:1607-1609.
    • (2010) Diabetes Care , vol.33 , pp. 1607-1609
    • Fadini, G.P.1    Boscaro, E.2    Albiero, M.3    Menegazzo, L.4    Frison, V.5    de Kreutzenberg, S.6    Agostini, C.7    Tiengo, A.8    Avogaro, A.9
  • 45
    • 6944233576 scopus 로고    scopus 로고
    • Role of interleukin-1beta in the development of retinopathy in rats: effect of antioxidants
    • Kowluru R.A., Odenbach S. Role of interleukin-1beta in the development of retinopathy in rats: effect of antioxidants. Invest. Ophthalmol. Vis. Sci. 2004, 45:4161-4166.
    • (2004) Invest. Ophthalmol. Vis. Sci. , vol.45 , pp. 4161-4166
    • Kowluru, R.A.1    Odenbach, S.2
  • 46
    • 84878391178 scopus 로고    scopus 로고
    • GLP-1-dependent and independent effects and molecular mechanisms of a dipeptidyl peptidase 4 inhibitor in vascular endothelial cells
    • Hu Y., Liu H.B., Simpson R.W., Dear A.E. GLP-1-dependent and independent effects and molecular mechanisms of a dipeptidyl peptidase 4 inhibitor in vascular endothelial cells. Mol. Biol. Rep. 2012, 40:2273-2279.
    • (2012) Mol. Biol. Rep. , vol.40 , pp. 2273-2279
    • Hu, Y.1    Liu, H.B.2    Simpson, R.W.3    Dear, A.E.4
  • 47
    • 0025769620 scopus 로고
    • Activated monocytes and granulocytes, capillary nonperfusion, and neovascularization in diabetic retinopathy
    • Schroder S., Palinski W., Schmid-Schonbein G.W. Activated monocytes and granulocytes, capillary nonperfusion, and neovascularization in diabetic retinopathy. Am. J. Pathol. 1991, 139:81-100.
    • (1991) Am. J. Pathol. , vol.139 , pp. 81-100
    • Schroder, S.1    Palinski, W.2    Schmid-Schonbein, G.W.3
  • 48
    • 79953269159 scopus 로고    scopus 로고
    • The significance of vascular and neural apoptosis to the pathology of diabetic retinopathy
    • Barber A.J., Gardner T.W., Abcouwer S.F. The significance of vascular and neural apoptosis to the pathology of diabetic retinopathy. Invest. Ophthalmol. Vis. Sci. 2011, 52:1156-1163.
    • (2011) Invest. Ophthalmol. Vis. Sci. , vol.52 , pp. 1156-1163
    • Barber, A.J.1    Gardner, T.W.2    Abcouwer, S.F.3
  • 49
    • 0742286836 scopus 로고    scopus 로고
    • Diabetes has an additive effect on neural apoptosis in rat retina with chronically elevated intraocular pressure
    • Kanamori A., Nakamura M., Mukuno H., Maeda H., Negi A. Diabetes has an additive effect on neural apoptosis in rat retina with chronically elevated intraocular pressure. Curr. Eye Res. 2004, 28:47-54.
    • (2004) Curr. Eye Res. , vol.28 , pp. 47-54
    • Kanamori, A.1    Nakamura, M.2    Mukuno, H.3    Maeda, H.4    Negi, A.5
  • 50
    • 0032529103 scopus 로고    scopus 로고
    • Neural apoptosis in the retina during experimental and human diabetes. Early onset and effect of insulin
    • Barber A.J., Lieth E., Khin S.A., Antonetti D.A., Buchanan A.G., Gardner T.W. Neural apoptosis in the retina during experimental and human diabetes. Early onset and effect of insulin. J. Clin. Invest. 1998, 102:783-791.
    • (1998) J. Clin. Invest. , vol.102 , pp. 783-791
    • Barber, A.J.1    Lieth, E.2    Khin, S.A.3    Antonetti, D.A.4    Buchanan, A.G.5    Gardner, T.W.6
  • 52
    • 78049508028 scopus 로고    scopus 로고
    • TRPV1 receptors are involved in protein nitration and Muller cell reaction in the acutely axotomized rat retina
    • Leonelli M., Martins D.O., Britto L.R. TRPV1 receptors are involved in protein nitration and Muller cell reaction in the acutely axotomized rat retina. Exp. Eye Res. 2010, 91:755-768.
    • (2010) Exp. Eye Res. , vol.91 , pp. 755-768
    • Leonelli, M.1    Martins, D.O.2    Britto, L.R.3
  • 53
    • 20444491588 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic polypeptide (GIP) stimulation of pancreatic beta-cell survival is dependent upon phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling, inactivation of the forkhead transcription factor Foxo1, and down-regulation of bax expression
    • Kim S.J., Winter K., Nian C., Tsuneoka M., Koda Y., McIntosh C.H. Glucose-dependent insulinotropic polypeptide (GIP) stimulation of pancreatic beta-cell survival is dependent upon phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling, inactivation of the forkhead transcription factor Foxo1, and down-regulation of bax expression. J. Biol. Chem. 2005, 280:22297-22307.
    • (2005) J. Biol. Chem. , vol.280 , pp. 22297-22307
    • Kim, S.J.1    Winter, K.2    Nian, C.3    Tsuneoka, M.4    Koda, Y.5    McIntosh, C.H.6
  • 54
    • 0036381989 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 treatment delays the onset of diabetes in 8week-old db/db mice
    • Wang Q., Brubaker P.L. Glucagon-like peptide-1 treatment delays the onset of diabetes in 8week-old db/db mice. Diabetologia 2002, 45:1263-1273.
    • (2002) Diabetologia , vol.45 , pp. 1263-1273
    • Wang, Q.1    Brubaker, P.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.