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Volumn 17, Issue 1, 2016, Pages 29-39

The role of immune cells in metabolism-related liver inflammation and development of non-alcoholic steatohepatitis (NASH)

Author keywords

Hepatic stellate cells (HSC); Kupffer cells; Non alcoholic steatohepatitis (NASH); Obesity; Steatosis; T regulatory cells (Tregs)

Indexed keywords

ADAPTIVE IMMUNITY; ADIPOSE TISSUE; ANTIGEN PRESENTATION; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL ACTIVATION; CELL DIFFERENTIATION; CELL FUNCTION; CELL INFILTRATION; CELL TRANSDIFFERENTIATION; DENDRITIC CELL; DISEASE COURSE; HEPATITIS; HUMAN; IMMUNOCOMPETENT CELL; IMMUNOREGULATION; INNATE IMMUNITY; KUPFFER CELL; LIPID METABOLISM; LIPOLYSIS; LIPOPROTEIN METABOLISM; LIVER METABOLISM; MACROPHAGE; MONOCYTE; NATURAL KILLER CELL; NATURAL KILLER T CELL; NEUTROPHIL; NEUTROPHIL LYMPHOCYTE RATIO; NONALCOHOLIC FATTY LIVER; NONHUMAN; OXIDATIVE STRESS; REGULATORY T LYMPHOCYTE; REVIEW; STELLATE CELL; TH17 CELL; ANIMAL; IMMUNOLOGY; INFLAMMATION; METABOLIC DISORDER;

EID: 84957549519     PISSN: 13899155     EISSN: 15732606     Source Type: Journal    
DOI: 10.1007/s11154-016-9339-2     Document Type: Review
Times cited : (111)

References (165)
  • 1
    • 33644547706 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: from steatosis to cirrhosis
    • COI: 1:CAS:528:DC%2BD28XhvVSktLo%3D, PID: 16447287
    • Farrell GC, Larter CZ. Nonalcoholic fatty liver disease: from steatosis to cirrhosis. Hepatology. 2006;43(2 Suppl 1):S99–112.
    • (2006) Hepatology , vol.43 , pp. 99-112
    • Farrell, G.C.1    Larter, C.Z.2
  • 2
    • 84904070301 scopus 로고    scopus 로고
    • Molecular pathways in non-alcoholic fatty liver disease
    • PID: 25045276
    • Berlanga A, Guiu-Jurado E. Molecular pathways in non-alcoholic fatty liver disease. Clin Exp Gastroenterol. 2014;7(1):221–39.
    • (2014) Clin Exp Gastroenterol , vol.7 , Issue.1 , pp. 221-239
    • Berlanga, A.1    Guiu-Jurado, E.2
  • 3
    • 77953971188 scopus 로고    scopus 로고
    • Disease progression of non-alcoholic fatty liver disease: a prospective study with paired liver biopsies at 3 years
    • PID: 20581244
    • Wong VW, Wong GL, Choi PC, et al. Disease progression of non-alcoholic fatty liver disease: a prospective study with paired liver biopsies at 3 years. Gut. 2010;59(7):969–74.
    • (2010) Gut , vol.59 , Issue.7 , pp. 969-974
    • Wong, V.W.1    Wong, G.L.2    Choi, P.C.3
  • 4
    • 84856957894 scopus 로고    scopus 로고
    • Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
    • COI: 1:CAS:528:DC%2BC38Xhs1GgsLc%3D, PID: 22297845
    • Henao-Mejia J, Elinav E, Jin C, et al. Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature. 2012;482(7384):179–85.
    • (2012) Nature , vol.482 , Issue.7384 , pp. 179-185
    • Henao-Mejia, J.1    Elinav, E.2    Jin, C.3
  • 5
    • 84891667680 scopus 로고    scopus 로고
    • Pro-inflammatory activated kupffer cells by lipids induce hepatic NKT cells deficiency through activation-induced cell death
    • PID: 24312613
    • Tang T, Sui Y, Lian M, Li Z, Hua J. Pro-inflammatory activated kupffer cells by lipids induce hepatic NKT cells deficiency through activation-induced cell death. PLoS ONE. 2013;8(12):e81949.
    • (2013) PLoS ONE , vol.8 , Issue.12
    • Tang, T.1    Sui, Y.2    Lian, M.3    Li, Z.4    Hua, J.5
  • 6
    • 1942518840 scopus 로고    scopus 로고
    • PPARs and the complex journey to obesity
    • COI: 1:CAS:528:DC%2BD2cXis1ektLk%3D, PID: 15057233
    • Evans RM, Barish GD, Wang YX. PPARs and the complex journey to obesity. Nat Med. 2004;10(4):355–61.
    • (2004) Nat Med , vol.10 , Issue.4 , pp. 355-361
    • Evans, R.M.1    Barish, G.D.2    Wang, Y.X.3
  • 7
    • 28044446543 scopus 로고    scopus 로고
    • The metabolic syndrome as a predictor of nonalcoholic fatty liver disease
    • COI: 1:CAS:528:DC%2BD2MXht1yntLrN, PID: 16287793
    • Hamaguchi M, Kojima T, Takeda N, et al. The metabolic syndrome as a predictor of nonalcoholic fatty liver disease. Ann Intern Med. 2005;143(10):722–8.
    • (2005) Ann Intern Med , vol.143 , Issue.10 , pp. 722-728
    • Hamaguchi, M.1    Kojima, T.2    Takeda, N.3
  • 8
    • 84859404868 scopus 로고    scopus 로고
    • Cusi K. Role of obesity and lipotoxicity in the development of nonalcoholic steatohepatitis: pathophysiology and clinical implications. 142(4):711–725.e6
    • Cusi K. Role of obesity and lipotoxicity in the development of nonalcoholic steatohepatitis: pathophysiology and clinical implications. Gastroenterol. 2012;142(4):711–725.e6.
    • (2012) Gastroenterol
  • 9
    • 77957812160 scopus 로고    scopus 로고
    • Increased visceral adipocyte lipolysis–a pathogenic role in nonalcoholic fatty liver disease?
    • PID: 20660030
    • Thörne A, Löfgren P, Hoffstedt J. Increased visceral adipocyte lipolysis–a pathogenic role in nonalcoholic fatty liver disease? J Clin Endocrinol Metab. 2010;95(10):E209–13.
    • (2010) J Clin Endocrinol Metab , vol.95 , Issue.10 , pp. 209-213
    • Thörne, A.1    Löfgren, P.2    Hoffstedt, J.3
  • 10
    • 78049522194 scopus 로고    scopus 로고
    • Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis
    • COI: 1:CAS:528:DC%2BC3cXhsFOnsrjP, PID: 21038418
    • Tilg H, Moschen A. Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis. Hepatology. 2010;52(5):1836–46.
    • (2010) Hepatology , vol.52 , Issue.5 , pp. 1836-1846
    • Tilg, H.1    Moschen, A.2
  • 11
    • 84983783142 scopus 로고    scopus 로고
    • Metabolic phenotype and adipose and liver features in the high fat western diet-induced mouse model of obesity-linked NAFLD
    • Luo Y, Burrington CM, Graff EC, et al. Metabolic phenotype and adipose and liver features in the high fat western diet-induced mouse model of obesity-linked NAFLD. Am J Physiol Endocrinol Metab 2015. doi:10.1152/ajpendo.00319.
    • (2015) Am J Physiol Endocrinol Metab
    • Luo, Y.1    Burrington, C.M.2    Graff, E.C.3
  • 12
    • 84952976765 scopus 로고    scopus 로고
    • Betaine prevented fructose-induced NAFLD by regulating LXRα/PPARα pathway and alleviating ER stress in rats
    • Ge CX, Yu R, Xu MX, et al. Betaine prevented fructose-induced NAFLD by regulating LXRα/PPARα pathway and alleviating ER stress in rats. Eur J Pharmacol. 2016;770:154–64.
    • (2016) Eur J Pharmacol , vol.770 , pp. 154-164
    • Ge, C.X.1    Yu, R.2    Xu, M.X.3
  • 13
    • 84856449557 scopus 로고    scopus 로고
    • A novel murine model for non-alcoholic steatohepatitis developed by combination of a high-fat diet and oxidized low-density lipoprotein
    • Yimin, Furumaki H, Matsuoka S, et al. A novel murine model for non-alcoholic steatohepatitis developed by combination of a high-fat diet and oxidized low-density lipoprotein. Lab Investig. 2012;92(2):265–81.
    • (2012) Lab Investig , vol.92 , Issue.2 , pp. 265-281
  • 14
    • 39149104311 scopus 로고    scopus 로고
    • Molecular basis and mechanisms of progression of non-alcoholic steatohepatitis
    • COI: 1:CAS:528:DC%2BD1cXitVGltL0%3D, PID: 18218340
    • Marra F, Gastaldelli A, Svegliati Baroni G, Tell G, Tiribelli C. Molecular basis and mechanisms of progression of non-alcoholic steatohepatitis. Trends Mol Med. 2008;14(2):72–81.
    • (2008) Trends Mol Med , vol.14 , Issue.2 , pp. 72-81
    • Marra, F.1    Gastaldelli, A.2    Svegliati Baroni, G.3    Tell, G.4    Tiribelli, C.5
  • 15
    • 79959517565 scopus 로고    scopus 로고
    • Human fatty liver disease: old questions and new insights
    • COI: 1:CAS:528:DC%2BC3MXnsleiurY%3D, PID: 21700865
    • Cohen JC, Horton JD, Hobbs HH. Human fatty liver disease: old questions and new insights. Science. 2011;332(6037):1519–23.
    • (2011) Science , vol.332 , Issue.6037 , pp. 1519-1523
    • Cohen, J.C.1    Horton, J.D.2    Hobbs, H.H.3
  • 16
    • 33644856005 scopus 로고    scopus 로고
    • Obesity and the role of adipose tissue in inflammation and metabolism
    • COI: 1:CAS:528:DC%2BD28Xhs1ehsrs%3D, PID: 16470013
    • Greenberg AS, Obin MS. Obesity and the role of adipose tissue in inflammation and metabolism. Am J Clin Nutr. 2006;83(2):461S–5S.
    • (2006) Am J Clin Nutr , vol.83 , Issue.2 , pp. 461S-465S
    • Greenberg, A.S.1    Obin, M.S.2
  • 17
    • 79953046341 scopus 로고    scopus 로고
    • Inflammatory mechanisms in obesity
    • COI: 1:CAS:528:DC%2BC3MXltlKnsL8%3D, PID: 21219177
    • Gregor MF, Hotamisligil GS. Inflammatory mechanisms in obesity. Annu Rev Immunol. 2011;29(1):415–45.
    • (2011) Annu Rev Immunol , vol.29 , Issue.1 , pp. 415-445
    • Gregor, M.F.1    Hotamisligil, G.S.2
  • 18
    • 84885436588 scopus 로고    scopus 로고
    • The complement anaphylatoxin C5a receptor contributes to obese adipose tissue inflammation and insulin resistance
    • COI: 1:CAS:528:DC%2BC3sXhsFOjurfJ, PID: 24043887
    • Phieler J, Chung K-J, Chatzigeorgiou A, et al. The complement anaphylatoxin C5a receptor contributes to obese adipose tissue inflammation and insulin resistance. J Immunol. 2013;191(8):4367–74.
    • (2013) J Immunol , vol.191 , Issue.8 , pp. 4367-4374
    • Phieler, J.1    Chung, K.-J.2    Chatzigeorgiou, A.3
  • 19
    • 84866107224 scopus 로고    scopus 로고
    • Lymphocytes in obesity-related adipose tissue inflammation
    • Chatzigeorgiou A, Karalis KP, Bornstein SR, Chavakis T. Lymphocytes in obesity-related adipose tissue inflammation. Diabetologia. 2012;55(10):2583–92.
    • (2012) Diabetologia , vol.55 , Issue.10 , pp. 2583-2592
  • 20
    • 84961612924 scopus 로고    scopus 로고
    • Chatzigeorgiou A, Chavakis T. Immune Cells and Metabolism
    • Chatzigeorgiou A, Chavakis T. Immune Cells and Metabolism. Handb Exp Pharmacol. 2015. doi:10.1007/164_2015_8.
    • (2015) Handb Exp Pharmacol
  • 21
    • 84958092597 scopus 로고    scopus 로고
    • Adipocyte-Specific Hif2α Deficiency Exacerbates Obesity-Induced Brown Adipose Tissue Dysfunction and Metabolic Dysregulation
    • Garcia-Martin R, Alexaki VI, Qin N, et al. Adipocyte-Specific Hif2α Deficiency Exacerbates Obesity-Induced Brown Adipose Tissue Dysfunction and Metabolic Dysregulation. Mol Cell Biol. 2015;36(3):376–93.
    • (2015) Mol Cell Biol , vol.36 , Issue.3 , pp. 376-393
    • Garcia-Martin, R.1    Alexaki, V.I.2    Qin, N.3
  • 22
    • 84904392112 scopus 로고    scopus 로고
    • Macrophages, immunity, and metabolic disease
    • McNelis JC, Olefsky JM. Macrophages, immunity, and metabolic disease. Immunity. 2015;41(1):36–48.
    • (2015) Immunity , vol.41 , Issue.1 , pp. 36-48
    • McNelis, J.C.1    Olefsky, J.M.2
  • 23
    • 84925873107 scopus 로고    scopus 로고
    • Immune regulation of metabolic homeostasis in health and disease
    • COI: 1:CAS:528:DC%2BC2MXls1agsrs%3D, PID: 25815992
    • Brestoff JR, Artis D. Immune regulation of metabolic homeostasis in health and disease. Cell. 2015;161(1):146–60.
    • (2015) Cell , vol.161 , Issue.1 , pp. 146-160
    • Brestoff, J.R.1    Artis, D.2
  • 24
    • 84904647950 scopus 로고    scopus 로고
    • Mehal W The inflammasome in liver injury and non-alcoholic Fatty liver disease. (Il):507–15
    • Mehal W The inflammasome in liver injury and non-alcoholic Fatty liver disease. Dig Dis. 2013;(Il):507–15.
    • (2013) Dig Dis
  • 25
    • 84899560268 scopus 로고    scopus 로고
    • Metabolically induced liver inflammation leads to NASH and differs from LPS- or IL-1β-induced chronic inflammation
    • COI: 1:CAS:528:DC%2BC2cXjt1Wisb4%3D, PID: 24566933
    • Liang W, Lindeman JH, Menke AL, et al. Metabolically induced liver inflammation leads to NASH and differs from LPS- or IL-1β-induced chronic inflammation. Lab Investig. 2014;94(5):491–502.
    • (2014) Lab Investig , vol.94 , Issue.5 , pp. 491-502
    • Liang, W.1    Lindeman, J.H.2    Menke, A.L.3
  • 26
    • 84863098121 scopus 로고    scopus 로고
    • Inflammation and fibrogenesis in steatohepatitis
    • COI: 1:CAS:528:DC%2BC38XkvFymtLo%3D, PID: 22310735
    • Fujii H, Kawada N. Inflammation and fibrogenesis in steatohepatitis. J Gastroenterol. 2012;47(3):215–25.
    • (2012) J Gastroenterol , vol.47 , Issue.3 , pp. 215-225
    • Fujii, H.1    Kawada, N.2
  • 27
    • 85052424065 scopus 로고    scopus 로고
    • Marra F, Tacke F. Roles for Chemokines in Liver Disease. 147(3):577–594.e1
    • Marra F, Tacke F. Roles for Chemokines in Liver Disease. Gastroenterology. 2014;147(3):577–594.e1.
    • (2014) Gastroenterology
  • 28
    • 0033647240 scopus 로고    scopus 로고
    • The neutrophil as a cellular source of chemokines
    • COI: 1:CAS:528:DC%2BD3cXptVent74%3D, PID: 11138776
    • Scapini P, Lapinet-Vera JA, Gasperini S, et al. The neutrophil as a cellular source of chemokines. Immunol Rev. 2000;177(1):195–203.
    • (2000) Immunol Rev , vol.177 , Issue.1 , pp. 195-203
    • Scapini, P.1    Lapinet-Vera, J.A.2    Gasperini, S.3
  • 30
    • 33344468233 scopus 로고    scopus 로고
    • Neutrophils and immunity: challenges and opportunities
    • COI: 1:CAS:528:DC%2BD28Xhsleltb8%3D, PID: 16498448
    • Nathan C Neutrophils and immunity: challenges and opportunities. Nat Rev Immunol. 2006;6(3):173–82.
    • (2006) Nat Rev Immunol , vol.6 , Issue.3 , pp. 173-182
    • Nathan, C.1
  • 31
    • 84896490614 scopus 로고    scopus 로고
    • The portal inflammatory infiltrate and ductular reaction in human nonalcoholic fatty liver disease
    • PID: 24254368
    • Gadd VL, Skoien R, Powell EE, et al. The portal inflammatory infiltrate and ductular reaction in human nonalcoholic fatty liver disease. Hepatology. 2014;59(4):1393–405.
    • (2014) Hepatology , vol.59 , Issue.4 , pp. 1393-1405
    • Gadd, V.L.1    Skoien, R.2    Powell, E.E.3
  • 32
    • 84855552939 scopus 로고    scopus 로고
    • Neutrophil to lymphocyte ratio: a new marker for predicting steatohepatitis and fibrosis in patients with nonalcoholic fatty liver disease
    • COI: 1:CAS:528:DC%2BC38XjtVKmsrg%3D, PID: 22097893
    • Alkhouri N, Morris-Stiff G, Campbell C, et al. Neutrophil to lymphocyte ratio: a new marker for predicting steatohepatitis and fibrosis in patients with nonalcoholic fatty liver disease. Liver Int. 2012;32(2):297–302.
    • (2012) Liver Int , vol.32 , Issue.2 , pp. 297-302
    • Alkhouri, N.1    Morris-Stiff, G.2    Campbell, C.3
  • 33
    • 18244390487 scopus 로고    scopus 로고
    • Myeloperoxidase: friend and foe
    • COI: 1:CAS:528:DC%2BD2MXktFentLw%3D, PID: 15689384
    • Klebanoff S Myeloperoxidase: friend and foe. J Leukoc Biol. 2005;77(5):598–625.
    • (2005) J Leukoc Biol , vol.77 , Issue.5 , pp. 598-625
    • Klebanoff, S.1
  • 34
    • 71149086343 scopus 로고    scopus 로고
    • Increased hepatic myeloperoxidase activity in obese subjects with nonalcoholic steatohepatitis
    • COI: 1:CAS:528:DC%2BD1MXhtlWiurzM, PID: 19729473
    • Rensen SS, Slaats Y, Nijhuis J, et al. Increased hepatic myeloperoxidase activity in obese subjects with nonalcoholic steatohepatitis. Am J Pathol. 2009;175(4):1473–82.
    • (2009) Am J Pathol , vol.175 , Issue.4 , pp. 1473-1482
    • Rensen, S.S.1    Slaats, Y.2    Nijhuis, J.3
  • 35
    • 84946100211 scopus 로고    scopus 로고
    • Myeloperoxidase-hepatocyte-stellate cell cross talk promotes hepatocyte injury and fibrosis in experimental nonalcoholic steatohepatitis
    • Pulli B, Ali M, Iwamoto Y, et al. Myeloperoxidase-hepatocyte-stellate cell cross talk promotes hepatocyte injury and fibrosis in experimental nonalcoholic steatohepatitis. Antioxid Redox Signal. 2015;23(16):1255–69.
    • (2015) Antioxid Redox Signal , vol.23 , Issue.16 , pp. 1255-1269
    • Pulli, B.1    Ali, M.2    Iwamoto, Y.3
  • 36
    • 84871445502 scopus 로고    scopus 로고
    • Neutrophil-derived myeloperoxidase aggravates non-alcoholic steatohepatitis in low-density lipoprotein receptor-deficient mice
    • COI: 1:CAS:528:DC%2BC3sXlsVKjsw%3D%3D, PID: 23285030
    • Rensen SS, Bieghs V, Xanthoulea S, et al. Neutrophil-derived myeloperoxidase aggravates non-alcoholic steatohepatitis in low-density lipoprotein receptor-deficient mice. PLoS ONE. 2012;7(12):e52411.
    • (2012) PLoS ONE , vol.7 , Issue.12
    • Rensen, S.S.1    Bieghs, V.2    Xanthoulea, S.3
  • 37
    • 0032739169 scopus 로고    scopus 로고
    • Formation of nitric oxide – derived oxidants by myeloperoxidase in monocytes
    • COI: 1:CAS:528:DyaK1MXnsVaiu70%3D, PID: 10559142
    • Hazen SL, Zhang R, Shen Z, et al. Formation of nitric oxide – derived oxidants by myeloperoxidase in monocytes. Circ Res. 1999;85:950–9.
    • (1999) Circ Res , vol.85 , pp. 950-959
    • Hazen, S.L.1    Zhang, R.2    Shen, Z.3
  • 38
    • 43049173503 scopus 로고    scopus 로고
    • Mammalian heme peroxidases: from molecular mechanisms to health implications
    • COI: 1:CAS:528:DC%2BD1cXlt1aiurY%3D, PID: 18331199
    • Davies MJ, Hawkins CL, Pattison DI, Rees MD. Mammalian heme peroxidases: from molecular mechanisms to health implications. Antioxid Redox Signal. 2008;10(7):1199–234.
    • (2008) Antioxid Redox Signal , vol.10 , Issue.7 , pp. 1199-1234
    • Davies, M.J.1    Hawkins, C.L.2    Pattison, D.I.3    Rees, M.D.4
  • 39
    • 46649090918 scopus 로고    scopus 로고
    • Protein tyrosine nitration-functional alteration or just a biomarker?
    • COI: 1:CAS:528:DC%2BD1cXosFWnt70%3D, PID: 18460345
    • Souza JM, Peluffo G, Radi R. Protein tyrosine nitration-functional alteration or just a biomarker? Free Radic Biol Med. 2008;45(4):357–66.
    • (2008) Free Radic Biol Med , vol.45 , Issue.4 , pp. 357-366
    • Souza, J.M.1    Peluffo, G.2    Radi, R.3
  • 40
    • 84864497351 scopus 로고    scopus 로고
    • Decreased nucleotide excision repair in steatotic livers associates with myeloperoxidase-immunoreactivity
    • COI: 1:CAS:528:DC%2BC38XhtFeitb%2FL, PID: 22100520
    • Schults MA, Nagle PW, Rensen SS, et al. Decreased nucleotide excision repair in steatotic livers associates with myeloperoxidase-immunoreactivity. Mutat Res. 2012;736(1–2):75–81.
    • (2012) Mutat Res , vol.736 , Issue.1-2 , pp. 75-81
    • Schults, M.A.1    Nagle, P.W.2    Rensen, S.S.3
  • 41
    • 84868671526 scopus 로고    scopus 로고
    • Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase
    • Talukdar S, Oh DY, Bandyopadhyay G, et al. Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase. Nat Med. 2013;18(9):1407–12.
    • (2013) Nat Med , vol.18 , Issue.9 , pp. 1407-1412
    • Talukdar, S.1    Oh, D.Y.2    Bandyopadhyay, G.3
  • 42
    • 84875900576 scopus 로고    scopus 로고
    • Imbalance between neutrophil elastase and its inhibitor α1-antitrypsin in obesity alters insulin sensitivity, inflammation, and energy expenditure
    • COI: 1:CAS:528:DC%2BC3sXltFGjtLs%3D, PID: 23562077
    • Mansuy-Aubert V, Zhou QL, Xie X, et al. Imbalance between neutrophil elastase and its inhibitor α1-antitrypsin in obesity alters insulin sensitivity, inflammation, and energy expenditure. Cell Metab. 2013;17(4):534–48.
    • (2013) Cell Metab , vol.17 , Issue.4 , pp. 534-548
    • Mansuy-Aubert, V.1    Zhou, Q.L.2    Xie, X.3
  • 43
    • 49249092790 scopus 로고    scopus 로고
    • Human neutrophil peptides upregulate expression of COX-2 and endothelin-1 by inducing oxidative stress
    • COI: 1:CAS:528:DC%2BD1cXnsVaktLc%3D, PID: 18441204
    • Syeda F, Tullis E, Slutsky AS, Zhang H. Human neutrophil peptides upregulate expression of COX-2 and endothelin-1 by inducing oxidative stress. Am J Physiol Heart Circ Physiol. 2008;294(6):H2769–74.
    • (2008) Am J Physiol Heart Circ Physiol , vol.294 , Issue.6 , pp. 2769-2774
    • Syeda, F.1    Tullis, E.2    Slutsky, A.S.3    Zhang, H.4
  • 44
    • 0035194835 scopus 로고    scopus 로고
    • A, Lee JH, de Azavedo J, et al. Direct and indirect bacterial killing functions of neutrophil defensins in lung explants
    • COI: 1:CAS:528:DC%2BD3MXos1agurk%3D, PID: 11597916
    • Porro G. A, Lee JH, de Azavedo J, et al. Direct and indirect bacterial killing functions of neutrophil defensins in lung explants. Am J Physiol Lung Cell Mol Physiol. 2001;281(5):L1240–7.
    • (2001) Am J Physiol Lung Cell Mol Physiol , vol.281 , Issue.5 , pp. 1240-1247
    • Porro, G.1
  • 45
    • 0033844287 scopus 로고    scopus 로고
    • Human neutrophil defensins selectively chemoattract naive T and immature dendritic cells
    • COI: 1:CAS:528:DC%2BD3cXltVGmsLo%3D, PID: 10914484
    • Yang D, Chen Q, Chertov O, Oppenheim JJ. Human neutrophil defensins selectively chemoattract naive T and immature dendritic cells. J Leukoc Biol. 2000;68(1):9–14.
    • (2000) J Leukoc Biol , vol.68 , Issue.1 , pp. 9-14
    • Yang, D.1    Chen, Q.2    Chertov, O.3    Oppenheim, J.J.4
  • 46
    • 84885174621 scopus 로고    scopus 로고
    • Transgenic expression of human neutrophil peptide-1 enhances hepatic fibrosis in mice fed a choline-deficient, L-amino acid-defined diet
    • COI: 1:CAS:528:DC%2BC3sXhs1Slsr7J, PID: 23682724
    • Ibusuki R, Uto H, Arima S, et al. Transgenic expression of human neutrophil peptide-1 enhances hepatic fibrosis in mice fed a choline-deficient, L-amino acid-defined diet. Liver Int. 2013;33(10):1549–56.
    • (2013) Liver Int , vol.33 , Issue.10 , pp. 1549-1556
    • Ibusuki, R.1    Uto, H.2    Arima, S.3
  • 47
    • 0034278725 scopus 로고    scopus 로고
    • Dendritic cell regulation of TH1-TH2 development
    • COI: 1:CAS:528:DC%2BD3cXmsVyitbc%3D, PID: 10973276
    • Moser M, Murphy KM. Dendritic cell regulation of TH1-TH2 development. Nat Immunol. 2000;1(3):199–205.
    • (2000) Nat Immunol , vol.1 , Issue.3 , pp. 199-205
    • Moser, M.1    Murphy, K.M.2
  • 48
    • 0032546352 scopus 로고    scopus 로고
    • Dendritic cells and the control of immunity
    • COI: 1:CAS:528:DyaK1cXitFWrsr8%3D, PID: 9521319
    • Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature. 1998;392(6673):245–52.
    • (1998) Nature , vol.392 , Issue.6673 , pp. 245-252
    • Banchereau, J.1    Steinman, R.M.2
  • 49
    • 0037131976 scopus 로고    scopus 로고
    • Mouse plasmacytoid cells: long-lived cells, heterogeneous in surface phenotype and function, that differentiate into CD8+ dendritic cells only after microbial stimulus
    • PID: 12438422
    • O’Keeffe M, Hochrein H, Vremec D, et al. Mouse plasmacytoid cells: long-lived cells, heterogeneous in surface phenotype and function, that differentiate into CD8+ dendritic cells only after microbial stimulus. J Exp Med. 2002;196(10):1307–19.
    • (2002) J Exp Med , vol.196 , Issue.10 , pp. 1307-1319
    • O’Keeffe, M.1    Hochrein, H.2    Vremec, D.3
  • 50
    • 77349095894 scopus 로고    scopus 로고
    • Origin and functional heterogeneity of non-lymphoid tissue dendritic cells in mice
    • COI: 1:CAS:528:DC%2BC3cXjslartrw%3D, PID: 20193012
    • Helft J, Ginhoux F, Bogunovic M, Merad M. Origin and functional heterogeneity of non-lymphoid tissue dendritic cells in mice. Immunol Rev. 2010;234(1):55–75.
    • (2010) Immunol Rev , vol.234 , Issue.1 , pp. 55-75
    • Helft, J.1    Ginhoux, F.2    Bogunovic, M.3    Merad, M.4
  • 51
    • 84881028719 scopus 로고    scopus 로고
    • Dendritic cells limit fibroinflammatory injury in nonalcoholic steatohepatitis in mice
    • COI: 1:CAS:528:DC%2BC3sXhtF2rurfO, PID: 23322710
    • Henning JR, Graffeo CS, Rehman A, et al. Dendritic cells limit fibroinflammatory injury in nonalcoholic steatohepatitis in mice. Hepatology. 2013;58(2):589–602.
    • (2013) Hepatology , vol.58 , Issue.2 , pp. 589-602
    • Henning, J.R.1    Graffeo, C.S.2    Rehman, A.3
  • 52
    • 70449355084 scopus 로고    scopus 로고
    • In liver fibrosis, dendritic cells govern hepatic inflammation in mice via TNF-α
    • COI: 1:CAS:528:DC%2BD1MXhtlOitrjK, PID: 19855130
    • Connolly M, Bedrosian A. In liver fibrosis, dendritic cells govern hepatic inflammation in mice via TNF-α. J Clin Invest. 2009;119(11):3213–25.
    • (2009) J Clin Invest , vol.119 , Issue.11 , pp. 3213-3225
    • Connolly, M.1    Bedrosian, A.2
  • 53
    • 79952034925 scopus 로고    scopus 로고
    • Impaired dendritic cell functions disrupt antigen-specific adaptive immune responses in mice with nonalcoholic fatty liver disease
    • COI: 1:CAS:528:DC%2BC3cXhtVSmtbvF, PID: 20195647
    • Miyake T, Akbar SM, Yoshida O, et al. Impaired dendritic cell functions disrupt antigen-specific adaptive immune responses in mice with nonalcoholic fatty liver disease. J Gastroenterol. 2010;45(8):859–67.
    • (2010) J Gastroenterol , vol.45 , Issue.8 , pp. 859-867
    • Miyake, T.1    Akbar, S.M.2    Yoshida, O.3
  • 54
    • 84866736144 scopus 로고    scopus 로고
    • Dendritic cell populations with different concentrations of lipid regulate tolerance and immunity in mouse and human liver
    • Ibrahim J, Nguyen AH, Rehman A, et al. Dendritic cell populations with different concentrations of lipid regulate tolerance and immunity in mouse and human liver. Gastroenterology. 2013;143(4):1061–72.
    • (2013) Gastroenterology , vol.143 , Issue.4 , pp. 1061-1072
    • Ibrahim, J.1    Nguyen, A.H.2    Rehman, A.3
  • 55
    • 84155175629 scopus 로고    scopus 로고
    • Dendritic cell regulation of carbon tetrachloride-induced murine liver fibrosis regression
    • PID: 21898476
    • Jiao J, Sastre D, Fiel MI, et al. Dendritic cell regulation of carbon tetrachloride-induced murine liver fibrosis regression. Hepatology. 2012;55(1):244–55.
    • (2012) Hepatology , vol.55 , Issue.1 , pp. 244-255
    • Jiao, J.1    Sastre, D.2    Fiel, M.I.3
  • 56
    • 84865461206 scopus 로고    scopus 로고
    • Identification of adipose tissue dendritic cells correlated with obesity-associated insulin-resistance and inducing Th17 responses in mice and patients
    • COI: 1:CAS:528:DC%2BC38XhtlantbrI, PID: 22596049
    • Bertola A, Ciucci T, Rousseau D, et al. Identification of adipose tissue dendritic cells correlated with obesity-associated insulin-resistance and inducing Th17 responses in mice and patients. Diabetes. 2012;61(9):2238–47.
    • (2012) Diabetes , vol.61 , Issue.9 , pp. 2238-2247
    • Bertola, A.1    Ciucci, T.2    Rousseau, D.3
  • 57
    • 80053651902 scopus 로고    scopus 로고
    • Interleukin-17 exacerbates hepatic steatosis and inflammation in non-alcoholic fatty liver disease
    • COI: 1:CAS:528:DC%2BC3MXhsFamsrbI, PID: 21985374
    • Tang Y, Bian Z, Zhao L, et al. Interleukin-17 exacerbates hepatic steatosis and inflammation in non-alcoholic fatty liver disease. Clin Exp Immunol. 2011;166(2):281–90.
    • (2011) Clin Exp Immunol , vol.166 , Issue.2 , pp. 281-290
    • Tang, Y.1    Bian, Z.2    Zhao, L.3
  • 58
    • 84953259630 scopus 로고    scopus 로고
    • Progression from nonalcoholic fatty liver to nonalcoholic steatohepatitis is marked by a higher frequency of Th17 cells in the liver and an increased Th17/resting regulatory T cell ratio in peripheral blood and in the liver
    • COI: 1:CAS:528:DC%2BC2MXitVeqt7rN, PID: 26621860
    • Rau M, Schilling AK, Meertens J, et al. Progression from nonalcoholic fatty liver to nonalcoholic steatohepatitis is marked by a higher frequency of Th17 cells in the liver and an increased Th17/resting regulatory T cell ratio in peripheral blood and in the liver. J Immunol. 2016;196(1):97–105.
    • (2016) J Immunol , vol.196 , Issue.1 , pp. 97-105
    • Rau, M.1    Schilling, A.K.2    Meertens, J.3
  • 59
    • 84899490742 scopus 로고    scopus 로고
    • IL-17 signaling accelerates the progression of nonalcoholic fatty liver disease in mice
    • COI: 1:CAS:528:DC%2BC2cXntFCmtbk%3D, PID: 24115079
    • Harley IT, Stankiewicz TE, Giles DA, et al. IL-17 signaling accelerates the progression of nonalcoholic fatty liver disease in mice. Hepatology. 2014;59(5):1830–9.
    • (2014) Hepatology , vol.59 , Issue.5 , pp. 1830-1839
    • Harley, I.T.1    Stankiewicz, T.E.2    Giles, D.A.3
  • 60
    • 17644393164 scopus 로고    scopus 로고
    • Tolerogenic role of kupffer cells in immune-mediated adverse drug reactions
    • COI: 1:CAS:528:DC%2BD2MXitlCisb0%3D, PID: 15767021
    • Ju C, Pohl LR. Tolerogenic role of kupffer cells in immune-mediated adverse drug reactions. Toxicology. 2005;209(2):109–12.
    • (2005) Toxicology , vol.209 , Issue.2 , pp. 109-112
    • Ju, C.1    Pohl, L.R.2
  • 62
    • 75449101395 scopus 로고    scopus 로고
    • Kupffer cells promote hepatic steatosis via interleukin-1beta-dependent suppression of peroxisome proliferator-activated receptor alpha activity
    • COI: 1:CAS:528:DC%2BC3cXisVGgu70%3D, PID: 20054868
    • Stienstra R, Saudale F, Duval C, et al. Kupffer cells promote hepatic steatosis via interleukin-1beta-dependent suppression of peroxisome proliferator-activated receptor alpha activity. Hepatology. 2010;51(2):511–22.
    • (2010) Hepatology , vol.51 , Issue.2 , pp. 511-522
    • Stienstra, R.1    Saudale, F.2    Duval, C.3
  • 63
    • 34548395788 scopus 로고    scopus 로고
    • Macrophage TNF-alpha contributes to insulin resistance and hepatic steatosis in diet-induced obesity
    • PID: 17578885
    • De Taeye BM, Novitskaya T, McGuinness OP, et al. Macrophage TNF-alpha contributes to insulin resistance and hepatic steatosis in diet-induced obesity. Am J Physiol Endocrinol Metab. 2007;293(3):E713–25.
    • (2007) Am J Physiol Endocrinol Metab , vol.293 , Issue.3 , pp. 713-725
    • De Taeye, B.M.1    Novitskaya, T.2    McGuinness, O.P.3
  • 64
    • 80355133234 scopus 로고    scopus 로고
    • Macrophage-mediated inflammation in metabolic disease
    • COI: 1:CAS:528:DC%2BC3MXht12iu7rF, PID: 21984069
    • Chawla A, Nguyen KD, Goh YP. Macrophage-mediated inflammation in metabolic disease. Nat Rev Immunol. 2011;11(11):738–49.
    • (2011) Nat Rev Immunol , vol.11 , Issue.11 , pp. 738-749
    • Chawla, A.1    Nguyen, K.D.2    Goh, Y.P.3
  • 66
    • 77449117735 scopus 로고    scopus 로고
    • Depletion of liver kupffer cells prevents the development of diet-induced hepatic steatosis and insulin resistance
    • COI: 1:CAS:528:DC%2BC3cXhvVyrurs%3D, PID: 19934001
    • Huang W, Metlakunta A, Dedousis N, et al. Depletion of liver kupffer cells prevents the development of diet-induced hepatic steatosis and insulin resistance. Diabetes. 2010;59:347–57.
    • (2010) Diabetes , vol.59 , pp. 347-357
    • Huang, W.1    Metlakunta, A.2    Dedousis, N.3
  • 67
    • 82655181355 scopus 로고    scopus 로고
    • Kupffer cell depletion prevents but has no therapeutic effect on metabolic and inflammatory changes induced by a high-fat diet
    • COI: 1:CAS:528:DC%2BC3MXhs1Wlt7vP, PID: 21873555
    • Lanthier N, Molendi-Coste O, Cani PD, et al. Kupffer cell depletion prevents but has no therapeutic effect on metabolic and inflammatory changes induced by a high-fat diet. Faseb J. 2011;25(12):4301–11.
    • (2011) Faseb J , vol.25 , Issue.12 , pp. 4301-4311
    • Lanthier, N.1    Molendi-Coste, O.2    Cani, P.D.3
  • 68
    • 73549090090 scopus 로고    scopus 로고
    • Kupffer cell activation is a causal factor for hepatic insulin resistance
    • COI: 1:CAS:528:DC%2BC3cXhsFKmur0%3D, PID: 19875703
    • Lanthier N, Molendi-Coste O, Horsmans Y, et al. Kupffer cell activation is a causal factor for hepatic insulin resistance. Am J Physiol Gastrointest Liver Physiol. 2010;298(1):G107–16.
    • (2010) Am J Physiol Gastrointest Liver Physiol , vol.298 , Issue.1 , pp. 107-116
    • Lanthier, N.1    Molendi-Coste, O.2    Horsmans, Y.3
  • 69
    • 37049003544 scopus 로고    scopus 로고
    • Kupffer cell heterogeneity: functional properties of bone marrow – derived and sessile hepatic macrophages
    • Klein I, Cornejo JC, Polakos NK, et al. Kupffer cell heterogeneity: functional properties of bone marrow – derived and sessile hepatic macrophages. Blood. 2007;110(12):4077–85.
    • (2007) Blood , vol.110 , Issue.12 , pp. 4077-4085
    • Klein, I.1    Cornejo, J.C.2    Polakos, N.K.3
  • 70
    • 77951146612 scopus 로고    scopus 로고
    • C-C chemokine receptor 2 (CCR2) regulates the hepatic recruitment of myeloid cells that promote obesity-induced hepatic steatosis
    • COI: 1:CAS:528:DC%2BC3cXltFSmt78%3D, PID: 20103702
    • Obstfeld AE, Sugaru E, Thearle M, et al. C-C chemokine receptor 2 (CCR2) regulates the hepatic recruitment of myeloid cells that promote obesity-induced hepatic steatosis. Diabetes. 2010;59(4):916–25.
    • (2010) Diabetes , vol.59 , Issue.4 , pp. 916-925
    • Obstfeld, A.E.1    Sugaru, E.2    Thearle, M.3
  • 71
    • 84878752311 scopus 로고    scopus 로고
    • CCR2 and CD44 promote inflammatory cell recruitment during fatty liver formation in a lithogenic diet fed mouse model
    • COI: 1:CAS:528:DC%2BC3sXhtVSkur3P, PID: 23762326
    • Egan CE, Daugherity EK, Rogers AB, et al. CCR2 and CD44 promote inflammatory cell recruitment during fatty liver formation in a lithogenic diet fed mouse model. PLoS ONE. 2013;8(6):e65247.
    • (2013) PLoS ONE , vol.8 , Issue.6
    • Egan, C.E.1    Daugherity, E.K.2    Rogers, A.B.3
  • 72
    • 84883788474 scopus 로고    scopus 로고
    • Functional role of intrahepatic monocyte subsets for the progression of liver inflammation and liver fibrosis in vivo
    • PID: 23259611
    • Tacke F Functional role of intrahepatic monocyte subsets for the progression of liver inflammation and liver fibrosis in vivo. Fibrogenesis Tissue Repair. 2012;5:S27.
    • (2012) Fibrogenesis Tissue Repair , vol.5 , pp. 27
    • Tacke, F.1
  • 73
    • 84861872575 scopus 로고    scopus 로고
    • Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2
    • COI: 1:CAS:528:DC%2BC38XhtVGlsrrI, PID: 22442158
    • Miura K, Yang L, van Rooijen N, Ohnishi H, Seki E. Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2. Am J Physiol Gastrointest Liver Physiol. 2012;302(11):G1310–21.
    • (2012) Am J Physiol Gastrointest Liver Physiol , vol.302 , Issue.11 , pp. 1310-1321
    • Miura, K.1    Yang, L.2    van Rooijen, N.3    Ohnishi, H.4    Seki, E.5
  • 74
    • 84870042853 scopus 로고    scopus 로고
    • Kuppfer cells trigger nonalcoholic steatohepatitis development in diet-induced mouse model through tumor necrosis factor-α production
    • COI: 1:CAS:528:DC%2BC38XhslansbvJ, PID: 23066023
    • Tosello-Trampont AC, Landes SG, Nguyen V, Novobrantseva TI, Hahn YS. Kuppfer cells trigger nonalcoholic steatohepatitis development in diet-induced mouse model through tumor necrosis factor-α production. J Biol Chem. 2012;287(48):40161–72.
    • (2012) J Biol Chem , vol.287 , Issue.48 , pp. 40161-40172
    • Tosello-Trampont, A.C.1    Landes, S.G.2    Nguyen, V.3    Novobrantseva, T.I.4    Hahn, Y.S.5
  • 75
    • 67650480409 scopus 로고    scopus 로고
    • Telmisartan attenuates progression of steatohepatitis in mice: role of hepatic macrophage infiltration and effects on adipose tissue
    • COI: 1:CAS:528:DC%2BD1MXhtVWjtb3K, PID: 19386026
    • Kudo H, Yata Y, Takahara T, et al. Telmisartan attenuates progression of steatohepatitis in mice: role of hepatic macrophage infiltration and effects on adipose tissue. Liver Int. 2009;29(7):988–96.
    • (2009) Liver Int , vol.29 , Issue.7 , pp. 988-996
    • Kudo, H.1    Yata, Y.2    Takahara, T.3
  • 76
    • 84872801313 scopus 로고    scopus 로고
    • Activation of CD11b + kupffer cells/macrophages as a common cause for exacerbation of TNF/Fas-ligand-dependent hepatitis in hypercholesterolemic mice
    • COI: 1:CAS:528:DC%2BC3sXitVymtLo%3D, PID: 23372642
    • Nakashima H, Ogawa Y, Shono S, et al. Activation of CD11b + kupffer cells/macrophages as a common cause for exacerbation of TNF/Fas-ligand-dependent hepatitis in hypercholesterolemic mice. PLoS ONE. 2013;8(1):e49339.
    • (2013) PLoS ONE , vol.8 , Issue.1
    • Nakashima, H.1    Ogawa, Y.2    Shono, S.3
  • 77
    • 0042165989 scopus 로고    scopus 로고
    • Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis
    • PID: 12891546
    • Feldstein AE, Canbay A, Angulo P, et al. Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis. Gastroenterology. 2003;125(2):437–43.
    • (2003) Gastroenterology , vol.125 , Issue.2 , pp. 437-443
    • Feldstein, A.E.1    Canbay, A.2    Angulo, P.3
  • 78
    • 0142151769 scopus 로고    scopus 로고
    • Kupffer cell engulfment of apoptotic bodies stimulates death ligand and cytokine expression
    • COI: 1:CAS:528:DC%2BD3sXpsVOntrs%3D, PID: 14578857
    • Canbay A, Feldstein AE, Higuchi H, et al. Kupffer cell engulfment of apoptotic bodies stimulates death ligand and cytokine expression. Hepatology. 2003;38(5):1188–98.
    • (2003) Hepatology , vol.38 , Issue.5 , pp. 1188-1198
    • Canbay, A.1    Feldstein, A.E.2    Higuchi, H.3
  • 79
    • 77449117735 scopus 로고    scopus 로고
    • Depletion of liver kupffer cells prevents the development of diet-induced hepatic steatosis and insulin resistance
    • COI: 1:CAS:528:DC%2BC3cXhvVyrurs%3D, PID: 19934001
    • Huang W, Metlakunta A, Dedousis N, et al. Depletion of liver kupffer cells prevents the development of diet-induced hepatic steatosis and insulin resistance. Diabetes. 2010;59(2):347–57.
    • (2010) Diabetes , vol.59 , Issue.2 , pp. 347-357
    • Huang, W.1    Metlakunta, A.2    Dedousis, N.3
  • 80
    • 84921907856 scopus 로고    scopus 로고
    • IL-1 signaling in obesity-induced hepatic lipogenesis and steatosis
    • PID: 25216251
    • Negrin KA, Roth Flach RJ, DiStefano MT, et al. IL-1 signaling in obesity-induced hepatic lipogenesis and steatosis. PLoS ONE. 2014;9(9):e107265.
    • (2014) PLoS ONE , vol.9 , Issue.9
    • Negrin, K.A.1    Roth Flach, R.J.2    DiStefano, M.T.3
  • 81
    • 84898879701 scopus 로고    scopus 로고
    • Lack of interleukin-1α in kupffer cells attenuates liver inflammation and expression of inflammatory cytokines in hypercholesterolaemic mice
    • COI: 1:CAS:528:DC%2BC2cXjs1Klsbg%3D, PID: 24582082
    • Olteanu S, Kandel-Kfir M, Shaish A, et al. Lack of interleukin-1α in kupffer cells attenuates liver inflammation and expression of inflammatory cytokines in hypercholesterolaemic mice. Dig Liver Dis. 2014;46(5):433–9.
    • (2014) Dig Liver Dis , vol.46 , Issue.5 , pp. 433-439
    • Olteanu, S.1    Kandel-Kfir, M.2    Shaish, A.3
  • 82
    • 0346037268 scopus 로고    scopus 로고
    • Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages
    • COI: 1:CAS:528:DC%2BD38XpsFakurs%3D, PID: 12376530
    • Kunjathoor VV, Febbraio M, Podrez EA, et al. Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages. J Biol Chem. 2002;277(51):49982–8.
    • (2002) J Biol Chem , vol.277 , Issue.51 , pp. 49982-49988
    • Kunjathoor, V.V.1    Febbraio, M.2    Podrez, E.A.3
  • 83
    • 0034051080 scopus 로고    scopus 로고
    • Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species
    • Podrez EA, Febbraio M, Sheibani N, et al. Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species. J Clin Invest. 2000;105(8):1095–108.
    • (2000) J Clin Invest , vol.105 , Issue.8 , pp. 1095-1108
    • Podrez, E.A.1    Febbraio, M.2    Sheibani, N.3
  • 84
    • 84859081972 scopus 로고    scopus 로고
    • Internalization of modified lipids by CD36 and SR-a leads to hepatic inflammation and lysosomal cholesterol storage in kupffer cells
    • Bieghs V, Verheyen F, van Gorp PJ, et al. Internalization of modified lipids by CD36 and SR-a leads to hepatic inflammation and lysosomal cholesterol storage in kupffer cells. PLoS ONE. 2012;7(3):1–7.
    • (2012) PLoS ONE , vol.7 , Issue.3 , pp. 1-7
    • Bieghs, V.1    Verheyen, F.2    van Gorp, P.J.3
  • 85
    • 84880953279 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis: the role of oxidized low-density lipoproteins
    • COI: 1:CAS:528:DC%2BC3sXhtF2kurc%3D, PID: 23183522
    • Walenbergh SM, Koek GH, Bieghs V, Shiri-Sverdlov R. Non-alcoholic steatohepatitis: the role of oxidized low-density lipoproteins. J Hepatol. 2013;58(4):801–10.
    • (2013) J Hepatol , vol.58 , Issue.4 , pp. 801-810
    • Walenbergh, S.M.1    Koek, G.H.2    Bieghs, V.3    Shiri-Sverdlov, R.4
  • 86
    • 84880178234 scopus 로고    scopus 로고
    • Trapping of oxidized LDL in lysosomes of kupffer cells is a trigger for hepatic inflammation
    • Bieghs V, Walenbergh SM, Hendrikx T, van Gorp PJ, et al. Trapping of oxidized LDL in lysosomes of kupffer cells is a trigger for hepatic inflammation. Liver Int. 2013;33(7):1056–61.
    • (2013) Liver Int , vol.33 , Issue.7 , pp. 1056-1061
    • Bieghs, V.1    Walenbergh, S.M.2    Hendrikx, T.3    van Gorp, P.J.4
  • 87
    • 77952717393 scopus 로고    scopus 로고
    • Role of scavenger receptor A and CD36 in diet-induced nonalcoholic steatohepatitis in hyperlipidemic mice
    • COI: 1:CAS:528:DC%2BC3cXnslars70%3D, PID: 20206177
    • Bieghs V, Wouters K, van Gorp PJ, et al. Role of scavenger receptor A and CD36 in diet-induced nonalcoholic steatohepatitis in hyperlipidemic mice. Gastroenterology. 2010;138(7):2477–86.
    • (2010) Gastroenterology , vol.138 , Issue.7 , pp. 2477-2486
    • Bieghs, V.1    Wouters, K.2    van Gorp, P.J.3
  • 88
    • 84862669638 scopus 로고    scopus 로고
    • Toxic lipids stored by kupffer cells correlates with their pro-inflammatory phenotype at an early stage of steatohepatitis
    • COI: 1:CAS:528:DC%2BC38XovV2gu7g%3D, PID: 22425624
    • Leroux A, Ferrere G, Godie V, et al. Toxic lipids stored by kupffer cells correlates with their pro-inflammatory phenotype at an early stage of steatohepatitis. J Hepatol. 2012;57(1):141–9.
    • (2012) J Hepatol , vol.57 , Issue.1 , pp. 141-149
    • Leroux, A.1    Ferrere, G.2    Godie, V.3
  • 89
    • 84891607476 scopus 로고    scopus 로고
    • Macrophage specific caspase-1/11 deficiency protects against cholesterol crystallization and hepatic inflammation in hyperlipidemic mice
    • Hendrikx T, Bieghs V, Walenbergh SM, et al. Macrophage specific caspase-1/11 deficiency protects against cholesterol crystallization and hepatic inflammation in hyperlipidemic mice. PLoS ONE. 2013;8(12):e78792.
    • (2013) PLoS ONE , vol.8 , Issue.12 , pp. 78792
    • Hendrikx, T.1    Bieghs, V.2    Walenbergh, S.M.3
  • 90
    • 84921905230 scopus 로고    scopus 로고
    • Cholesterol-Lowering drugs Cause Dissolution of Cholesterol Crystals and Disperse Kupffer Cell Crown-Like Structures During Resolution of NASH
    • Ioannou GN, Van Rooyen DM, Savard C, et al. Cholesterol-Lowering drugs Cause Dissolution of Cholesterol Crystals and Disperse Kupffer Cell Crown-Like Structures During Resolution of NASH. J Lipid Res. 2015;56:277–85.
    • (2015) J Lipid Res , vol.56 , pp. 277-285
    • Ioannou, G.N.1    Van Rooyen, D.M.2    Savard, C.3
  • 91
    • 68949192624 scopus 로고    scopus 로고
    • Hepatic regulatory T cells and kupffer cells are crucial mediators of systemic T cell tolerance to antigens targeting murine liver
    • COI: 1:CAS:528:DC%2BD1MXhtVKrtrjK, PID: 19575456
    • Breous E, Somanathan S, Vandenberghe LH, Wilson JM. Hepatic regulatory T cells and kupffer cells are crucial mediators of systemic T cell tolerance to antigens targeting murine liver. Hepatology. 2009;50(2):612–21.
    • (2009) Hepatology , vol.50 , Issue.2 , pp. 612-621
    • Breous, E.1    Somanathan, S.2    Vandenberghe, L.H.3    Wilson, J.M.4
  • 92
    • 84858710276 scopus 로고    scopus 로고
    • Kupffer cells ameliorate hepatic insulin resistance induced by high-fat diet rich in monounsaturated fatty acids: the evidence for the involvement of alternatively activated macrophages
    • Papackova Z, Palenickova E, Dankova H, et al. Kupffer cells ameliorate hepatic insulin resistance induced by high-fat diet rich in monounsaturated fatty acids: the evidence for the involvement of alternatively activated macrophages. Nutr Metab (Lond). 2012;9(1):1–15.
    • (2012) Nutr Metab (Lond) , vol.9 , Issue.1 , pp. 1-15
    • Papackova, Z.1    Palenickova, E.2    Dankova, H.3
  • 93
    • 84927514683 scopus 로고    scopus 로고
    • Regulation of human helper T cell subset differentiation by cytokines
    • COI: 1:CAS:528:DC%2BC2MXmtVaqt74%3D, PID: 25879814
    • Schmitt N, Ueno H. Regulation of human helper T cell subset differentiation by cytokines. Curr Opin Immunol. 2015;34:130–6.
    • (2015) Curr Opin Immunol , vol.34 , pp. 130-136
    • Schmitt, N.1    Ueno, H.2
  • 94
    • 0033227692 scopus 로고    scopus 로고
    • Th1/Th2 cells
    • COI: 1:STN:280:DC%2BD3c%2Fks1Srtw%3D%3D, PID: 10579123
    • Romagnani S Th1/Th2 cells. Inflamm Bowel Dis. 1999;5(4):285–94.
    • (1999) Inflamm Bowel Dis , vol.5 , Issue.4 , pp. 285-294
    • Romagnani, S.1
  • 95
    • 77951679801 scopus 로고    scopus 로고
    • Anatomy of a murder: how cytotoxic T cells and NK cells are activated, develop, and eliminate their targets
    • COI: 1:CAS:528:DC%2BC3cXnt1Kjsb0%3D, PID: 20536551
    • Lieberman J Anatomy of a murder: how cytotoxic T cells and NK cells are activated, develop, and eliminate their targets. Immunol Rev. 2010;235(1):5–9.
    • (2010) Immunol Rev , vol.235 , Issue.1 , pp. 5-9
    • Lieberman, J.1
  • 96
    • 84857037496 scopus 로고    scopus 로고
    • Altered phenotype and functionality of circulating immune cells characterize adult patients with nonalcoholic steatohepatitis
    • PID: 21845516
    • Inzaugarat ME, Ferreyra Solari NE, Billordo LA, et al. Altered phenotype and functionality of circulating immune cells characterize adult patients with nonalcoholic steatohepatitis. J Clin Immunol. 2011;31(6):1120–30.
    • (2011) J Clin Immunol , vol.31 , Issue.6 , pp. 1120-1130
    • Inzaugarat, M.E.1    Ferreyra Solari, N.E.2    Billordo, L.A.3
  • 97
    • 0029658578 scopus 로고    scopus 로고
    • Reactivity and specificity of CD8+ T cells in mice with defects in the MHC class I antigen-presenting pathway
    • COI: 1:CAS:528:DyaK28Xlslyluro%3D, PID: 8872488
    • Ljunggren H-G, Glas R, Sandberg JK, Kärre K. Reactivity and specificity of CD8+ T cells in mice with defects in the MHC class I antigen-presenting pathway. Immunol Rev. 1996;151(1):123–48.
    • (1996) Immunol Rev , vol.151 , Issue.1 , pp. 123-148
    • Ljunggren, H.-G.1    Glas, R.2    Sandberg, J.K.3    Kärre, K.4
  • 98
    • 84880687134 scopus 로고    scopus 로고
    • Antigen peptide transporter 1 is involved in the development of fructose-induced hepatic steatosis in mice
    • COI: 1:CAS:528:DC%2BC3sXhtFOlurrL, PID: 23488792
    • Arindkar S, Bhattacharjee J, Kumar JM, et al. Antigen peptide transporter 1 is involved in the development of fructose-induced hepatic steatosis in mice. J Gastroenterol Hepatol. 2013;28(8):1403–9.
    • (2013) J Gastroenterol Hepatol , vol.28 , Issue.8 , pp. 1403-1409
    • Arindkar, S.1    Bhattacharjee, J.2    Kumar, J.M.3
  • 99
    • 39449128293 scopus 로고    scopus 로고
    • Th17 T cells: linking innate and adaptive immunity
    • COI: 1:CAS:528:DC%2BD1cXisVSrsLo%3D, PID: 18023589
    • Stockinger B, Veldhoen M, Martin B. Th17 T cells: linking innate and adaptive immunity. Semin Immunol. 2007;19(6):353–61.
    • (2007) Semin Immunol , vol.19 , Issue.6 , pp. 353-361
    • Stockinger, B.1    Veldhoen, M.2    Martin, B.3
  • 100
    • 84881393577 scopus 로고    scopus 로고
    • IL-17 a plays a critical role in the pathogenesis of liver fibrosis through hepatic stellate cell activation
    • COI: 1:CAS:528:DC%2BC3sXht1Witb3F, PID: 23842754
    • Tan Z, Qian X, Jiang R, et al. IL-17 a plays a critical role in the pathogenesis of liver fibrosis through hepatic stellate cell activation. J Immunol. 2013;191(4):1835–44.
    • (2013) J Immunol , vol.191 , Issue.4 , pp. 1835-1844
    • Tan, Z.1    Qian, X.2    Jiang, R.3
  • 101
    • 84874371212 scopus 로고    scopus 로고
    • Expression of interleukin-17 associated with disease progression and liver fibrosis with hepatitis B virus infection: IL-17 in HBV infection
    • COI: 1:CAS:528:DC%2BC3sXlsFCrtbo%3D, PID: 23448394
    • Du WJ, Zhen JH, Zeng Z-Q, et al. Expression of interleukin-17 associated with disease progression and liver fibrosis with hepatitis B virus infection: IL-17 in HBV infection. Diagn Pathol. 2013;8(1):40.
    • (2013) Diagn Pathol , vol.8 , Issue.1 , pp. 40
    • Du, W.J.1    Zhen, J.H.2    Zeng, Z.-Q.3
  • 102
    • 84865461464 scopus 로고    scopus 로고
    • Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice
    • COI: 1:CAS:528:DC%2BC38Xht1Kisr%2FM, PID: 22687286
    • Meng F, Wang K, Aoyama T, et al. Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice. Gastroenterology. 2012;143(3):765–76.
    • (2012) Gastroenterology , vol.143 , Issue.3 , pp. 765-766
    • Meng, F.1    Wang, K.2    Aoyama, T.3
  • 103
    • 46249101518 scopus 로고    scopus 로고
    • How regulatory T cells work
    • COI: 1:CAS:528:DC%2BD1cXns1ehs7g%3D, PID: 18566595
    • Vignali DA, Collison LW, Workman CJ. How regulatory T cells work. Nat Rev Immunol. 2008;8(7):523–32.
    • (2008) Nat Rev Immunol , vol.8 , Issue.7 , pp. 523-532
    • Vignali, D.A.1    Collison, L.W.2    Workman, C.J.3
  • 104
    • 84859416933 scopus 로고    scopus 로고
    • Regulatory T cells: mechanisms of differentiation and function
    • COI: 1:CAS:528:DC%2BC38XmsVKmurs%3D, PID: 22224781
    • Josefowicz SZ, Lu L-F, Rudensky AY. Regulatory T cells: mechanisms of differentiation and function. Annu Rev Immunol. 2012;30:531–64.
    • (2012) Annu Rev Immunol , vol.30 , pp. 531-564
    • Josefowicz, S.Z.1    Lu, L.-F.2    Rudensky, A.Y.3
  • 105
    • 84876461373 scopus 로고    scopus 로고
    • Circulating regulatory T cells are reduced in obesity and may identify subjects at increased metabolic and cardiovascular risk
    • COI: 1:CAS:528:DC%2BC3sXmt1KmsLg%3D, PID: 23592653
    • Wagner NM, Brandhorst G, Czepluch F, et al. Circulating regulatory T cells are reduced in obesity and may identify subjects at increased metabolic and cardiovascular risk. Obesity. 2013;21(3):461–8.
    • (2013) Obesity , vol.21 , Issue.3 , pp. 461-468
    • Wagner, N.M.1    Brandhorst, G.2    Czepluch, F.3
  • 106
    • 84904035279 scopus 로고    scopus 로고
    • Adipose tissue-resident regulatory T cells: phenotypic specialization, functions and therapeutic potential
    • COI: 1:CAS:528:DC%2BC2cXhtFeitrnL, PID: 24484282
    • Cipolletta D Adipose tissue-resident regulatory T cells: phenotypic specialization, functions and therapeutic potential. Immunology. 2014;142(4):517–25.
    • (2014) Immunology , vol.142 , Issue.4 , pp. 517-525
    • Cipolletta, D.1
  • 107
    • 68349148211 scopus 로고    scopus 로고
    • Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters
    • COI: 1:CAS:528:DC%2BD1MXovFyltr4%3D, PID: 19633656
    • Feuerer M, Herrero L, Cipolletta D, et al. Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med. 2009;15(8):930–9.
    • (2009) Nat Med , vol.15 , Issue.8 , pp. 930-939
    • Feuerer, M.1    Herrero, L.2    Cipolletta, D.3
  • 108
    • 84862986986 scopus 로고    scopus 로고
    • PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue treg cells
    • COI: 1:CAS:528:DC%2BC38XpsVWitb4%3D, PID: 22722857
    • Cipolletta D, Feuerer M, Li A, et al. PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue treg cells. Nature. 2012;486(7404):549–53.
    • (2012) Nature , vol.486 , Issue.7404 , pp. 549-553
    • Cipolletta, D.1    Feuerer, M.2    Li, A.3
  • 109
    • 84949257630 scopus 로고    scopus 로고
    • Depletion of fat-resident treg cells prevents age-associated insulin resistance
    • COI: 1:CAS:528:DC%2BC2MXhvVKrtbnF, PID: 26580014
    • Bapat SP, Myoung Suh J, Fang S, et al. Depletion of fat-resident treg cells prevents age-associated insulin resistance. Nature. 2015;528(7580):137–41.
    • (2015) Nature , vol.528 , Issue.7580 , pp. 137-141
    • Bapat, S.P.1    Myoung Suh, J.2    Fang, S.3
  • 110
    • 36349010120 scopus 로고    scopus 로고
    • A high-fat diet and regulatory T cells influence susceptibility to endotoxin-induced liver injury
    • COI: 1:CAS:528:DC%2BD2sXhtlOiu7bF, PID: 17661402
    • Ma X, Hua J, Mohamood AR, et al. A high-fat diet and regulatory T cells influence susceptibility to endotoxin-induced liver injury. Hepatology. 2007;46(5):1519–29.
    • (2007) Hepatology , vol.46 , Issue.5 , pp. 1519-1529
    • Ma, X.1    Hua, J.2    Mohamood, A.R.3
  • 111
    • 0033682056 scopus 로고    scopus 로고
    • B7/CD28 costimulation is essential for the homeostasis of the CD4+ CD25+ immunoregulatory T cells that control autoimmune diabetes
    • Salomon B, Lenschow DJ, Rhee L, et al. B7/CD28 costimulation is essential for the homeostasis of the CD4+ CD25+ immunoregulatory T cells that control autoimmune diabetes. Immunity. 2000;12(4):431–40.
    • (2000) Immunity , vol.12 , Issue.4 , pp. 431-440
    • Salomon, B.1    Lenschow, D.J.2    Rhee, L.3
  • 112
    • 84930752976 scopus 로고    scopus 로고
    • CD28 deletion improves obesity-induced liver steatosis but increases adiposity in mice
    • COI: 1:CAS:528:DC%2BC2MXms1Glu7k%3D
    • Poggi M, Morin SO, Bastelica D, et al. CD28 deletion improves obesity-induced liver steatosis but increases adiposity in mice. Int J Obes. 2015;39(6):977–85.
    • (2015) Int J Obes , vol.39 , Issue.6 , pp. 977-985
    • Poggi, M.1    Morin, S.O.2    Bastelica, D.3
  • 113
    • 84927761703 scopus 로고    scopus 로고
    • Dual role of B7 costimulation in obesity-related nonalcoholic steatohepatitis and metabolic dysregulation
    • COI: 1:CAS:528:DC%2BC2cXhs1Wlu73F, PID: 24845056
    • Chatzigeorgiou A, Chung K-J, Garcia-Martin R, et al. Dual role of B7 costimulation in obesity-related nonalcoholic steatohepatitis and metabolic dysregulation. Hepatology. 2014;60(4):1196–210.
    • (2014) Hepatology , vol.60 , Issue.4 , pp. 1196-1210
    • Chatzigeorgiou, A.1    Chung, K.-J.2    Garcia-Martin, R.3
  • 114
    • 84897849549 scopus 로고    scopus 로고
    • T-cell costimulation protects obesity-induced adipose inflammation and insulin resistance
    • COI: 1:CAS:528:DC%2BC2cXls1OisLc%3D, PID: 24222350
    • Zhong J, Rao X, Braunstein Z, et al. T-cell costimulation protects obesity-induced adipose inflammation and insulin resistance. Diabetes. 2014;63(4):1289–302.
    • (2014) Diabetes , vol.63 , Issue.4 , pp. 1289-1302
    • Zhong, J.1    Rao, X.2    Braunstein, Z.3
  • 115
    • 84894377101 scopus 로고    scopus 로고
    • Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance
    • COI: 1:CAS:528:DC%2BC2cXivFantrk%3D, PID: 24492375
    • Chatzigeorgiou A, Seijkens T, Zarzycka B, et al. Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance. Proc Natl Acad Sci U S A. 2014;111(7):2686–91.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , Issue.7 , pp. 2686-2691
    • Chatzigeorgiou, A.1    Seijkens, T.2    Zarzycka, B.3
  • 116
    • 84878565127 scopus 로고    scopus 로고
    • CD40 deficiency in mice exacerbates obesity-induced adipose tissue inflammation, hepatic steatosis, and insulin resistance
    • COI: 1:CAS:528:DC%2BC3sXpt1yjtrY%3D, PID: 23482447
    • Guo CA, Kogan S, Amano SU, et al. CD40 deficiency in mice exacerbates obesity-induced adipose tissue inflammation, hepatic steatosis, and insulin resistance. Am J Physiol Endocrinol Metab. 2013;304(9):E951–63.
    • (2013) Am J Physiol Endocrinol Metab , vol.304 , Issue.9 , pp. 951-963
    • Guo, C.A.1    Kogan, S.2    Amano, S.U.3
  • 117
    • 84902241067 scopus 로고    scopus 로고
    • Coinhibitory suppression of T cell activation by CD40 protects against obesity and adipose tissue inflammation in mice
    • COI: 1:CAS:528:DC%2BC2cXpsVelu70%3D, PID: 24664276
    • Wolf D, Jehle F, Michel NA, et al. Coinhibitory suppression of T cell activation by CD40 protects against obesity and adipose tissue inflammation in mice. Circulation. 2014;129(23):2414–25.
    • (2014) Circulation , vol.129 , Issue.23 , pp. 2414-2425
    • Wolf, D.1    Jehle, F.2    Michel, N.A.3
  • 118
    • 84928925813 scopus 로고    scopus 로고
    • Blocking CD40-TRAF6 interactions by small-molecule inhibitor 6860766 ameliorates the complications of diet-induced obesity in mice
    • van den Berg SM, Seijkens TT, Kusters PJ, et al. Blocking CD40-TRAF6 interactions by small-molecule inhibitor 6860766 ameliorates the complications of diet-induced obesity in mice. Int J Obes. 2015;39(5):782–90.
    • (2015) Int J Obes , vol.39 , Issue.5 , pp. 782-790
    • van den Berg, S.M.1    Seijkens, T.T.2    Kusters, P.J.3
  • 119
    • 80052971178 scopus 로고    scopus 로고
    • CD40L deficiency ameliorates adipose tissue inflammation and metabolic manifestations of obesity in mice
    • COI: 1:CAS:528:DC%2BC3MXhtFGls7fM, PID: 21817098
    • Poggi M, Engel D, Christ A, et al. CD40L deficiency ameliorates adipose tissue inflammation and metabolic manifestations of obesity in mice. Arterioscler Thromb Vasc Biol. 2011;31(10):2251–60.
    • (2011) Arterioscler Thromb Vasc Biol , vol.31 , Issue.10 , pp. 2251-2260
    • Poggi, M.1    Engel, D.2    Christ, A.3
  • 120
    • 34247842744 scopus 로고    scopus 로고
    • The biology of NKT cells
    • COI: 1:CAS:528:DC%2BD2sXltlansr4%3D, PID: 17150027
    • Bendelac A, Savage PB, Teyton L. The biology of NKT cells. Annu Rev Immunol. 2007;25(1):297–336.
    • (2007) Annu Rev Immunol , vol.25 , Issue.1 , pp. 297-336
    • Bendelac, A.1    Savage, P.B.2    Teyton, L.3
  • 121
    • 73449142810 scopus 로고    scopus 로고
    • Kupffer cell and interleukin-12 dependent loss of natural killer T cells in hepatosteatosis
    • COI: 1:CAS:528:DC%2BC3cXhsVCqtbk%3D, PID: 20034047
    • Kremer M, Thomas E, Milton RJ, et al. Kupffer cell and interleukin-12 dependent loss of natural killer T cells in hepatosteatosis. Hepatology. 2010;51(1):130–41.
    • (2010) Hepatology , vol.51 , Issue.1 , pp. 130-141
    • Kremer, M.1    Thomas, E.2    Milton, R.J.3
  • 122
    • 84860794660 scopus 로고    scopus 로고
    • Activation of invariant natural killer T cells by lipid excess promotes tissue inflammation, insulin resistance, and hepatic steatosis in obese mice
    • COI: 1:CAS:528:DC%2BC38XnsVGntLs%3D, PID: 22493234
    • Wu L, Parekh VV, Gabriel CL, et al. Activation of invariant natural killer T cells by lipid excess promotes tissue inflammation, insulin resistance, and hepatic steatosis in obese mice. Proc Natl Acad Sci U S A. 2012;109(19):E1143–52.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , Issue.19 , pp. 1143-1152
    • Wu, L.1    Parekh, V.V.2    Gabriel, C.L.3
  • 123
    • 77952730087 scopus 로고    scopus 로고
    • Accumulation of NKT cells in progressive nonalcoholic fatty liver disease
    • COI: 1:CAS:528:DC%2BC3cXnslyqtro%3D, PID: 20512988
    • Syn WK, Oo YH, Pereira TA, et al. Accumulation of NKT cells in progressive nonalcoholic fatty liver disease. Hepatology. 2010;51(6):1998–2007.
    • (2010) Hepatology , vol.51 , Issue.6 , pp. 1998-2007
    • Syn, W.K.1    Oo, Y.H.2    Pereira, T.A.3
  • 124
    • 78751479915 scopus 로고    scopus 로고
    • Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis
    • COI: 1:CAS:528:DC%2BC3MXitVeks78%3D, PID: 20967826
    • Syn WK, Choi SS, Liaskou E, et al. Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis. Hepatology. 2011;53(1):106–15.
    • (2011) Hepatology , vol.53 , Issue.1 , pp. 106-115
    • Syn, W.K.1    Choi, S.S.2    Liaskou, E.3
  • 125
    • 35948954244 scopus 로고    scopus 로고
    • Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver
    • COI: 1:CAS:528:DC%2BD1cXitVKgsbc%3D, PID: 18195085
    • Friedman SL. Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Physiol Rev. 2008;88(1):125–72.
    • (2008) Physiol Rev , vol.88 , Issue.1 , pp. 125-172
    • Friedman, S.L.1
  • 126
    • 84885367185 scopus 로고    scopus 로고
    • Role of hepatic progenitor cells in nonalcoholic fatty liver disease development: cellular cross-talks and molecular networks
    • PID: 24113587
    • Carpino G, Renzi A, Onori P, Gaudio E. Role of hepatic progenitor cells in nonalcoholic fatty liver disease development: cellular cross-talks and molecular networks. Int J Mol Sci. 2013;14(10):20112–30.
    • (2013) Int J Mol Sci , vol.14 , Issue.10 , pp. 20112-20130
    • Carpino, G.1    Renzi, A.2    Onori, P.3    Gaudio, E.4
  • 127
    • 67349229867 scopus 로고    scopus 로고
    • Hepatic stellate cell lipid droplets: a specialized lipid droplet for retinoid storage
    • COI: 1:CAS:528:DC%2BD1MXntVKls7o%3D, PID: 19071229
    • Blaner WS, O’Byrne SM, Wongsiriroj N, et al. Hepatic stellate cell lipid droplets: a specialized lipid droplet for retinoid storage. Biochim Biophys Acta. 2009;1791(6):467–73.
    • (2009) Biochim Biophys Acta , vol.1791 , Issue.6 , pp. 467-473
    • Blaner, W.S.1    O’Byrne, S.M.2    Wongsiriroj, N.3
  • 128
    • 0033962940 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma transcriptional regulation is involved in platelet-derived growth factor-induced proliferation of human hepatic stellate cells
    • COI: 1:CAS:528:DC%2BD3cXks1Ojug%3D%3D, PID: 10613734
    • Galli A, Crabb D, Price D, et al. Peroxisome proliferator-activated receptor gamma transcriptional regulation is involved in platelet-derived growth factor-induced proliferation of human hepatic stellate cells. Hepatology. 2000;31(1):101–8.
    • (2000) Hepatology , vol.31 , Issue.1 , pp. 101-108
    • Galli, A.1    Crabb, D.2    Price, D.3
  • 129
    • 32044435802 scopus 로고    scopus 로고
    • Adipogenic Phenotype of Hepatic Stellate Cells
    • COI: 1:CAS:528:DC%2BD2MXhtlShsbfP, PID: 16344597
    • Tsukamoto H Adipogenic Phenotype of Hepatic Stellate Cells. Alcohol Clin Exp Res. 2005;29(Supplement):132S–3S.
    • (2005) Alcohol Clin Exp Res , vol.29 , pp. 132S-133S
    • Tsukamoto, H.1
  • 130
    • 0033855572 scopus 로고    scopus 로고
    • Ligands of peroxisome proliferator-activated receptor gamma modulate profibrogenic and proinflammatory actions in hepatic stellate cells
    • COI: 1:CAS:528:DC%2BD3cXmtVWrurY%3D, PID: 10930382
    • Marra F, Efsen E, Romanelli RG, et al. Ligands of peroxisome proliferator-activated receptor gamma modulate profibrogenic and proinflammatory actions in hepatic stellate cells. Gastroenterology. 2000;119(2):466–78.
    • (2000) Gastroenterology , vol.119 , Issue.2 , pp. 466-478
    • Marra, F.1    Efsen, E.2    Romanelli, R.G.3
  • 131
    • 0036082703 scopus 로고    scopus 로고
    • Antidiabetic thiazolidinediones inhibit collagen synthesis and hepatic stellate cell activation in vivo and in vitro
    • COI: 1:CAS:528:DC%2BD38Xlt12gsLw%3D, PID: 12055599
    • Galli A, Crabb DW, Ceni E, et al. Antidiabetic thiazolidinediones inhibit collagen synthesis and hepatic stellate cell activation in vivo and in vitro. Gastroenterology. 2002;122(7):1924–40.
    • (2002) Gastroenterology , vol.122 , Issue.7 , pp. 1924-1940
    • Galli, A.1    Crabb, D.W.2    Ceni, E.3
  • 132
    • 0028245546 scopus 로고
    • Immunohistochemical identification of Ito cells and their myofibroblastic transformation in adult human liver
    • Enzan H, Himeno H, Iwamura S, et al. Immunohistochemical identification of Ito cells and their myofibroblastic transformation in adult human liver. Virchows Arch. 1994;424(3):249–56.
    • (1994) Virchows Arch , vol.424 , Issue.3 , pp. 249-256
    • Enzan, H.1    Himeno, H.2    Iwamura, S.3
  • 133
    • 47349109305 scopus 로고    scopus 로고
    • Molecular mechanism of hepatic stellate cell activation and antifibrotic therapeutic strategies
    • COI: 1:CAS:528:DC%2BD1cXotFeju7Y%3D, PID: 18600385
    • Li JT, Liao ZX, Ping J, Xu D, Wang H. Molecular mechanism of hepatic stellate cell activation and antifibrotic therapeutic strategies. J Gastroenterol. 2008;43(6):419–28.
    • (2008) J Gastroenterol , vol.43 , Issue.6 , pp. 419-428
    • Li, J.T.1    Liao, Z.X.2    Ping, J.3    Xu, D.4    Wang, H.5
  • 134
    • 0032835657 scopus 로고    scopus 로고
    • CYP2E1-mediated oxidative stress induces collagen type I expression in rat hepatic stellate cells
    • COI: 1:CAS:528:DyaK1MXmslWgtLg%3D, PID: 10498651
    • Nieto N, Friedman S. CYP2E1-mediated oxidative stress induces collagen type I expression in rat hepatic stellate cells. Hepatology. 1999;30(4):987–96.
    • (1999) Hepatology , vol.30 , Issue.4 , pp. 987-996
    • Nieto, N.1    Friedman, S.2
  • 135
    • 0035145392 scopus 로고    scopus 로고
    • Involvement of reactive oxygen species and nitric oxide radicals in activation and proliferation of rat hepatic stellate cells
    • COI: 1:CAS:528:DC%2BD3MXhtFKgt7g%3D, PID: 11169066
    • Svegliati-Baroni G, Saccomanno S, Van Goor H, et al. Involvement of reactive oxygen species and nitric oxide radicals in activation and proliferation of rat hepatic stellate cells. Liver. 2001;21(1):1–12.
    • (2001) Liver , vol.21 , Issue.1 , pp. 1-12
    • Svegliati-Baroni, G.1    Saccomanno, S.2    Van Goor, H.3
  • 136
    • 0028838193 scopus 로고
    • Activation of hepatic stellate cells by TGFa and collagen type I is mediated by oxidative stress through c-myb expression
    • COI: 1:CAS:528:DyaK28XltF2gtg%3D%3D, PID: 7593635
    • Lee KS, Buck M, Houglum K, Chojkier M. Activation of hepatic stellate cells by TGFa and collagen type I is mediated by oxidative stress through c-myb expression. J Clin Invest. 1995;96(November):2461–8.
    • (1995) J Clin Invest , vol.96 , Issue.November , pp. 2461-2468
    • Lee, K.S.1    Buck, M.2    Houglum, K.3    Chojkier, M.4
  • 137
    • 0035893937 scopus 로고    scopus 로고
    • The role of kupffer cell oxidant production in early ethanol-induced liver disease
    • COI: 1:CAS:528:DC%2BD3MXptVahtLs%3D, PID: 11744328
    • Wheeler M The role of kupffer cell oxidant production in early ethanol-induced liver disease. Free Radic Biol Med. 2001;31(12):1544–9.
    • (2001) Free Radic Biol Med , vol.31 , Issue.12 , pp. 1544-1549
    • Wheeler, M.1
  • 138
    • 0030992053 scopus 로고    scopus 로고
    • Transforming growth factor-β gene expression in normal and fibrotic rat liver
    • De Bleser PJ, Niki T, Rogiers V, Geerts A. Transforming growth factor-β gene expression in normal and fibrotic rat liver. J Hepatol 1997;26(4):886–893.
    • (1997) J Hepatol , vol.26 , Issue.4 , pp. 886-893
    • De Bleser, P.J.1    Niki, T.2    Rogiers, V.3    Geerts, A.4
  • 139
    • 0032586690 scopus 로고    scopus 로고
    • The role of TGFβ1 in initiating hepatic stellate cell activation in vivo
    • COI: 1:CAS:528:DyaK1MXlt1SktA%3D%3D, PID: 9927153
    • Hellerbrand C, Stefanovic B, Giordano F, Burchardt ER, Brenner DA. The role of TGFβ1 in initiating hepatic stellate cell activation in vivo. J Hepatol. 1999;30(1):77–87.
    • (1999) J Hepatol , vol.30 , Issue.1 , pp. 77-87
    • Hellerbrand, C.1    Stefanovic, B.2    Giordano, F.3    Burchardt, E.R.4    Brenner, D.A.5
  • 140
    • 84910029457 scopus 로고    scopus 로고
    • Astaxanthin prevents TGFβ1-induced pro-fibrogenic gene expression by inhibiting Smad3 activation in hepatic stellate cells
    • COI: 1:CAS:528:DC%2BC2cXhvVSlsrfI
    • Yang Y, Kim B, Park YK, Koo SI, Lee JY. Astaxanthin prevents TGFβ1-induced pro-fibrogenic gene expression by inhibiting Smad3 activation in hepatic stellate cells. Biochim Biophys Acta - Gen Subj. 2015;1850(1):178–85.
    • (2015) Biochim Biophys Acta - Gen Subj , vol.1850 , Issue.1 , pp. 178-185
    • Yang, Y.1    Kim, B.2    Park, Y.K.3    Koo, S.I.4    Lee, J.Y.5
  • 141
    • 84884984479 scopus 로고    scopus 로고
    • Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice
    • COI: 1:CAS:528:DC%2BC2MXhtl2mur%2FJ, PID: 23553591
    • Pradere JP, Kluwe J, De Minicis S, et al. Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice. Hepatology. 2013;58(4):1461–73.
    • (2013) Hepatology , vol.58 , Issue.4 , pp. 1461-1473
    • Pradere, J.P.1    Kluwe, J.2    De Minicis, S.3
  • 142
    • 11144325650 scopus 로고    scopus 로고
    • Inhibition of inhibitor of κB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis
    • COI: 1:CAS:528:DC%2BD2MXhtFaht7s%3D, PID: 15633128
    • Oakley F, Meso M, Iredale JP, et al. Inhibition of inhibitor of κB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis. Gastroenterology. 2005;128(1):108–20.
    • (2005) Gastroenterology , vol.128 , Issue.1 , pp. 108-120
    • Oakley, F.1    Meso, M.2    Iredale, J.P.3
  • 143
    • 84865504141 scopus 로고    scopus 로고
    • Sterile inflammation in the liver
    • COI: 1:CAS:528:DC%2BC38XhsFGjtL%2FP, PID: 22982943
    • Kubes P, Mehal WZ. Sterile inflammation in the liver. Gastroenterology. 2012;143(5):1158–72.
    • (2012) Gastroenterology , vol.143 , Issue.5 , pp. 1158-1172
    • Kubes, P.1    Mehal, W.Z.2
  • 144
    • 84924230659 scopus 로고    scopus 로고
    • Cellular and molecular functions of hepatic stellate cells in inflammatory responses and liver immunology
    • PID: 25568859
    • Weiskirchen R, Tacke F. Cellular and molecular functions of hepatic stellate cells in inflammatory responses and liver immunology. Hepatobiliary Surg Nutr. 2014;3(6):344–63.
    • (2014) Hepatobiliary Surg Nutr , vol.3 , Issue.6 , pp. 344-363
    • Weiskirchen, R.1    Tacke, F.2
  • 145
    • 0037335208 scopus 로고    scopus 로고
    • Influence of leptin in the development of hepatic fibrosis produced in mice by Schistosoma mansoni infection and by chronic carbon tetrachloride administration
    • COI: 1:CAS:528:DC%2BD3sXhtVemtbo%3D, PID: 12586293
    • Potter JJ, Rennie-tankesley L, Mezey E. Influence of leptin in the development of hepatic fibrosis produced in mice by Schistosoma mansoni infection and by chronic carbon tetrachloride administration. J Hepatol. 2003;38(4):281–8.
    • (2003) J Hepatol , vol.38 , Issue.4 , pp. 281-288
    • Potter, J.J.1    Rennie-tankesley, L.2    Mezey, E.3
  • 146
    • 0036329894 scopus 로고    scopus 로고
    • Serum leptin in NASH correlates with hepatic steatosis but not fibrosis: a manifestation of lipotoxicity?
    • COI: 1:CAS:528:DC%2BD38XmsVansL0%3D, PID: 12143049
    • Chitturi S, Farrell G, Frost L, et al. Serum leptin in NASH correlates with hepatic steatosis but not fibrosis: a manifestation of lipotoxicity? Hepatology. 2002;36(2):403–9.
    • (2002) Hepatology , vol.36 , Issue.2 , pp. 403-409
    • Chitturi, S.1    Farrell, G.2    Frost, L.3
  • 147
    • 1242272717 scopus 로고    scopus 로고
    • Expression of leptin and leptin receptor during the development of liver fibrosis and cirrhosis
    • COI: 1:CAS:528:DC%2BD2cXhslOgsrk%3D, PID: 14758566
    • Otte C, Otte JM, Strodthoff D, et al. Expression of leptin and leptin receptor during the development of liver fibrosis and cirrhosis. Exp Clin Endocrinol Diabetes. 2004;112(1):10–7.
    • (2004) Exp Clin Endocrinol Diabetes , vol.112 , Issue.1 , pp. 10-17
    • Otte, C.1    Otte, J.M.2    Strodthoff, D.3
  • 148
    • 0036234147 scopus 로고    scopus 로고
    • Leptin receptor–mediated signaling regulates hepatic fibrogenesis and remodeling of extracellular matrix in the rat
    • COI: 1:CAS:528:DC%2BD38Xkt1Cru7k%3D, PID: 11984526
    • Ikejima K, Takei Y, Honda H, et al. Leptin receptor–mediated signaling regulates hepatic fibrogenesis and remodeling of extracellular matrix in the rat. Gastroenterology. 2002;122(5):1399–410.
    • (2002) Gastroenterology , vol.122 , Issue.5 , pp. 1399-1410
    • Ikejima, K.1    Takei, Y.2    Honda, H.3
  • 149
    • 67650963803 scopus 로고    scopus 로고
    • Kupffer cells mediate leptin-induced liver fibrosis
    • COI: 1:CAS:528:DC%2BD1MXhtVKrtrzM, PID: 19375424
    • Wang J, Leclercq I, Brymora JM, et al. Kupffer cells mediate leptin-induced liver fibrosis. Gastroenterology. 2009;137(2):713–23.
    • (2009) Gastroenterology , vol.137 , Issue.2 , pp. 713-723
    • Wang, J.1    Leclercq, I.2    Brymora, J.M.3
  • 150
    • 78449240951 scopus 로고    scopus 로고
    • Leptin promotes the myofibroblastic phenotype in hepatic stellate cells by activating the hedgehog pathway
    • COI: 1:CAS:528:DC%2BC3cXhsVWgsrzF, PID: 20843817
    • Choi SS, Syn WK, Karaca GF, et al. Leptin promotes the myofibroblastic phenotype in hepatic stellate cells by activating the hedgehog pathway. J Biol Chem. 2010;285(47):36551–60.
    • (2010) J Biol Chem , vol.285 , Issue.47 , pp. 36551-36560
    • Choi, S.S.1    Syn, W.K.2    Karaca, G.F.3
  • 151
    • 0034680787 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors and hepatic stellate cell activation
    • COI: 1:CAS:528:DC%2BD3cXosVSksbo%3D, PID: 10969082
    • Miyahara T, Schrum L, Rippe R, et al. Peroxisome proliferator-activated receptors and hepatic stellate cell activation. J Biol Chem. 2000;275(46):35715–22.
    • (2000) J Biol Chem , vol.275 , Issue.46 , pp. 35715-35722
    • Miyahara, T.1    Schrum, L.2    Rippe, R.3
  • 152
    • 33747616182 scopus 로고    scopus 로고
    • Anti-adipogenic regulation underlies hepatic stellate cell transdifferentiation
    • COI: 1:CAS:528:DC%2BD28Xht1Sgt7jP, PID: 16958658
    • Tsukamoto H, She H, Hazra S, Cheng J, Miyahara T. Anti-adipogenic regulation underlies hepatic stellate cell transdifferentiation. J Gastroenterol Hepatol. 2006;21(Suppl 3):S102–5.
    • (2006) J Gastroenterol Hepatol , vol.21 , pp. 102-105
    • Tsukamoto, H.1    She, H.2    Hazra, S.3    Cheng, J.4    Miyahara, T.5
  • 153
    • 79959789940 scopus 로고    scopus 로고
    • Mann J. Epigenetic cell fate regulation of hepatic stellate cells
    • COI: 1:CAS:528:DC%2BC3MXhtFWjtLjI, PID: 21504520
    • Tsukamoto H, Zhu NL, Asahina K, Mann DA, Mann J. Epigenetic cell fate regulation of hepatic stellate cells. Hepatol Res. 2011;41(7):675–82.
    • (2011) Hepatol Res , vol.41 , Issue.7 , pp. 675-682
    • Tsukamoto, H.1    Zhu, N.L.2    Asahina, K.3    Mann, D.A.4
  • 154
    • 84927671391 scopus 로고    scopus 로고
    • Role of metabolic lipases and lipolytic metabolites in the pathogenesis of NAFLD
    • Fuchs CD, Claudel T, Trauner M. Role of metabolic lipases and lipolytic metabolites in the pathogenesis of NAFLD. Trends Endocrinol Metab. 2015;25(11):576–85.
    • (2015) Trends Endocrinol Metab , vol.25 , Issue.11 , pp. 576-585
    • Fuchs, C.D.1    Claudel, T.2    Trauner, M.3
  • 155
    • 84884860377 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 diabetes
    • PID: 23929732
    • Birkenfeld AL, Shulman GI. Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 diabetes. Hepatology. 2014;59(2):713–23.
    • (2014) Hepatology , vol.59 , Issue.2 , pp. 713-723
    • Birkenfeld, A.L.1    Shulman, G.I.2
  • 156
    • 34548272744 scopus 로고    scopus 로고
    • Toll-like receptor-4 signaling and kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis
    • COI: 1:CAS:528:DC%2BD2sXpvF2msbg%3D, PID: 17644211
    • Rivera CA, Adegboyega P, van Rooijen N, et al. Toll-like receptor-4 signaling and kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis. J Hepatol. 2007;47(4):571–9.
    • (2007) J Hepatol , vol.47 , Issue.4 , pp. 571-579
    • Rivera, C.A.1    Adegboyega, P.2    van Rooijen, N.3
  • 157
    • 84922709227 scopus 로고    scopus 로고
    • Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes
    • COI: 1:CAS:528:DC%2BC2MXisVSiu74%3D, PID: 25662011
    • Perry RJ, Camporez JP, Kursawe R, et al. Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes. Cell. 2015;160(4):745–58.
    • (2015) Cell , vol.160 , Issue.4 , pp. 745-758
    • Perry, R.J.1    Camporez, J.P.2    Kursawe, R.3
  • 158
    • 57349116780 scopus 로고    scopus 로고
    • Causes and metabolic consequences of fatty liver
    • COI: 1:CAS:528:DC%2BD1MXmt1yjug%3D%3D, PID: 18723451
    • Stefan N, Kantartzis K, Häring HU. Causes and metabolic consequences of fatty liver. Endocr Rev. 2008;29(7):939–60.
    • (2008) Endocr Rev , vol.29 , Issue.7 , pp. 939-960
    • Stefan, N.1    Kantartzis, K.2    Häring, H.U.3
  • 159
    • 84910020145 scopus 로고    scopus 로고
    • Pharmacological inhibition of the chemokine CXCL16 diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury
    • PID: 25372401
    • Wehr A, Baeck C, Ulmer F, et al. Pharmacological inhibition of the chemokine CXCL16 diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury. PLoS ONE. 2014;9(11):e112327.
    • (2014) PLoS ONE , vol.9 , Issue.11
    • Wehr, A.1    Baeck, C.2    Ulmer, F.3
  • 160
    • 84857055199 scopus 로고    scopus 로고
    • Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury
    • COI: 1:CAS:528:DC%2BC38Xlt1Srsrc%3D, PID: 21813474
    • Baeck C, Wehr A, Karlmark KR, et al. Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury. Gut. 2012;61(3):416–26.
    • (2012) Gut , vol.61 , Issue.3 , pp. 416-426
    • Baeck, C.1    Wehr, A.2    Karlmark, K.R.3
  • 161
    • 84961795060 scopus 로고    scopus 로고
    • CXC chemokine receptor 3 promotes steatohepatitis in mice through mediating inflammatory cytokines, macrophages and autophagy
    • Zhang X, Han J, Man K, et al. CXC chemokine receptor 3 promotes steatohepatitis in mice through mediating inflammatory cytokines, macrophages and autophagy. J Hepatol. 2016;64(1):160–70.
    • (2016) J Hepatol , vol.64 , Issue.1 , pp. 160-170
    • Zhang, X.1    Han, J.2    Man, K.3
  • 162
    • 84922696660 scopus 로고    scopus 로고
    • CXCL10 plays a key role as an inflammatory mediator and a non-invasive biomarker of non-alcoholic steatohepatitis
    • COI: 1:CAS:528:DC%2BC2cXhsF2lsrjO, PID: 25048951
    • Zhang X, Shen J, Man K, et al. CXCL10 plays a key role as an inflammatory mediator and a non-invasive biomarker of non-alcoholic steatohepatitis. J Hepatol. 2014;61(6):1365–75.
    • (2014) J Hepatol , vol.61 , Issue.6 , pp. 1365-1375
    • Zhang, X.1    Shen, J.2    Man, K.3
  • 163
    • 84886241987 scopus 로고    scopus 로고
    • STAT3-mediated attenuation of CCl4-induced mouse liver fibrosis by the protein kinase inhibitor sorafenib
    • COI: 1:CAS:528:DC%2BC3sXht1Kgsb%2FI, PID: 23948302
    • Deng YR, Ma HD, Tsuneyama K, et al. STAT3-mediated attenuation of CCl4-induced mouse liver fibrosis by the protein kinase inhibitor sorafenib. J Autoimmun. 2013;46:25–34.
    • (2013) J Autoimmun , vol.46 , pp. 25-34
    • Deng, Y.R.1    Ma, H.D.2    Tsuneyama, K.3
  • 164
    • 42549144094 scopus 로고    scopus 로고
    • Pharmacological IKK2 inhibition blocks liver steatosis and initiation of non-alcoholic steatohepatitis
    • COI: 1:CAS:528:DC%2BD1cXmt1antbg%3D, PID: 18408102
    • Beraza N, Malato Y, Vander Borght S, et al. Pharmacological IKK2 inhibition blocks liver steatosis and initiation of non-alcoholic steatohepatitis. Gut. 2008;57(5):655–63.
    • (2008) Gut , vol.57 , Issue.5 , pp. 655-663
    • Beraza, N.1    Malato, Y.2    Vander Borght, S.3
  • 165
    • 84943602280 scopus 로고    scopus 로고
    • Treatment of experimental non-alcoholic steatohepatitis by targeting α7 nicotinic acetylcholine receptor-mediated inflammatory responses in mice
    • Zhou Z, Liu Y, Chen X, Li F, Tong X, Ding Y, Tang C. Treatment of experimental non-alcoholic steatohepatitis by targeting α7 nicotinic acetylcholine receptor-mediated inflammatory responses in mice. Mol Med Rep. 2015;12(5):6925–31.
    • (2015) Mol Med Rep , vol.12 , Issue.5 , pp. 6925-6931
    • Zhou, Z.1    Liu, Y.2    Chen, X.3    Li, F.4    Tong, X.5    Ding, Y.6    Tang, C.7


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