Internalization of modified lipids by CD36 and SR-A leads to hepatic inflammation and lysosomal cholesterol storage in kupffer cells

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Bieghs, Veerle ^a   Verheyen, Fons ^a   van Gorp, Patrick J ^a   Hendrikx, Tim ^a   Wouters, Kristiaan ^b   Lütjohann, Dieter ^c   Gijbels, Marion J J ^a   Febbraio, Maria ^d   Binder, Christoph J ^e   Hofker, Marten H ^f   Shiri Sverdlov, Ronit ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b UNIV LILLE   (France)

^c UNIVERSITY OF BONN   (Germany)

^d LERNER RESEARCH INSTITUTE   (United States)

^e MEDICAL UNIVERSITY OF VIENNA   (Austria)

^f UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CD36 ANTIGEN; CHOLESTEROL; LIPID; LIPOPROTEIN; SCAVENGER RECEPTOR A; LOW DENSITY LIPOPROTEIN RECEPTOR; MSR1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MARROW; CELL FUNCTION; CELL MIGRATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DISEASE COURSE; FEMALE; HEPATITIS; INTERNALIZATION; KUPFFER CELL; LIPID STORAGE; LYSOSOME; MOUSE; NONALCOHOLIC FATTY LIVER; NONHUMAN; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MODIFICATION; ANIMAL; BONE MARROW TRANSPLANTATION; CHEMISTRY; FATTY LIVER; GENETICS; INFLAMMATION; LIPID METABOLISM; LIVER; METABOLISM; MOUSE MUTANT; PATHOLOGY;

MUS;

ANIMALS; ANTIGENS, CD36; BONE MARROW TRANSPLANTATION; CHOLESTEROL; FATTY LIVER; FEMALE; INFLAMMATION; KUPFFER CELLS; LIPID METABOLISM; LIPIDS; LIVER; LYSOSOMES; MICE; MICE, KNOCKOUT; RECEPTORS, LDL; SCAVENGER RECEPTORS, CLASS A;

EID: 84859081972     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0034378     Document Type: Article

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