Lack of interleukin-1α in Kupffer cells attenuates liver inflammation and expression of inflammatory cytokines in hypercholesterolaemic mice

Digestive and Liver Disease

Volumn 46, Issue 5, 2014, Pages 433-439

  Olteanu, Sarita ^a   Kandel Kfir, Michal ^a   Shaish, Aviv ^a   Almog, Tal ^a   Shemesh, Shay ^a   Barshack, Iris ^a,b   Apte, Ron N ^c   Harats, Dror ^a,b   Kamari, Yehuda ^a,b  

^a SHEBA MEDICAL CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

^c BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

Cytokine; Fatty liver; IL 1; Inflammation; Kupffer cells; NASH

Indexed keywords

ALANINE AMINOTRANSFERASE; CHOLESTEROL; CYTOKINE; GADOLINIUM CHLORIDE; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; MESSENGER RNA; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; IL1R1 PROTEIN, HUMAN; INTERLEUKIN 1 RECEPTOR TYPE I; INTERLEUKIN 6; SAA2 PROTEIN, MOUSE; SERUM AMYLOID A;

ABLATION THERAPY; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROGENIC DIET; BONE MARROW CELL; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL LIVER LEVEL; CONTROLLED STUDY; GENE EXPRESSION; HISTOPATHOLOGY; HYPERCHOLESTEROLEMIA; INFLAMMATION; KUPFFER CELL; MALE; MOUSE; NONALCOHOLIC FATTY LIVER; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRIACYLGLYCEROL BLOOD LEVEL; ANIMAL; BLOOD; DEFICIENCY; FATTY LIVER; FEMALE; GENETICS; HEPATITIS; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PORTAL VEIN; VASCULITIS;

ALANINE TRANSAMINASE; ANIMALS; CHOLESTEROL; DIET, ATHEROGENIC; FATTY LIVER; FEMALE; GENE EXPRESSION; HEPATITIS; HYPERCHOLESTEROLEMIA; INTERLEUKIN-1ALPHA; INTERLEUKIN-1BETA; INTERLEUKIN-6; KUPFFER CELLS; MALE; MICE; MICE, KNOCKOUT; PORTAL SYSTEM; RECEPTORS, INTERLEUKIN-1 TYPE I; RNA, MESSENGER; SERUM AMYLOID A PROTEIN; TRIGLYCERIDES; TUMOR NECROSIS FACTOR-ALPHA; VASCULITIS;

EID: 84898879701     PISSN: 15908658     EISSN: 18783562     Source Type: Journal    
DOI: 10.1016/j.dld.2014.01.156     Document Type: Article

References (26)

1. Satapathy S.K., Sanyal A.J. Novel treatment modalities for nonalcoholic steatohepatitis. Trends in Endocrinology and Metabolism 2010, 21:668-675.
2. Tilg H., Moschen A.R. IL-1 cytokine family members and NAFLD: neglected in metabolic liver inflammation. Journal of Hepatology 2011, 55:960-962.
3. Tilg H., Moschen A.R. Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis. Hepatology 2010, 52:1836-1846.
4. Alkhouri N., Dixon L.J., Feldstein A.E. Lipotoxicity in nonalcoholic fatty liver disease: not all lipids are created equal. Expert Review of Gastroenterology & Hepatology 2009, 3:445-451.
5. Min H.K., Kapoor A., Fuchs M., et al. Increased hepatic synthesis and dysregulation of cholesterol metabolism is associated with the severity of nonalcoholic fatty liver disease. Cell Metabolism 2012, 15:665-674.
6. Alkhouri N., Carter-Kent C., Feldstein A.E. Apoptosis in nonalcoholic fatty liver disease: diagnostic and therapeutic implications. Expert Review of Gastroenterology & Hepatology 2011, 5:201-212.
7. Malhi H., Kaufman R.J. Endoplasmic reticulum stress in liver disease. Journal of Hepatology 2011, 54:795-809.
8. Dinarello C.A. Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Blood 2011, 117:3720-3732.
9. Kamari Y., Werman-Venkert R., Shaish A., et al. Differential role and tissue specificity of interleukin-1alpha gene expression in atherogenesis and lipid metabolism. Atherosclerosis 2007, 195:31-38.
10. Dinarello C.A. Immunological and inflammatory functions of the interleukin-1 family. Annual Review of Immunology 2009, 27:519-550.
11. Dinarello C.A. Biologic basis for interleukin-1 in disease. Blood 1996, 87:2095-2147.
12. Miura K., Kodama Y., Inokuchi S., et al. Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. Gastroenterology 2010, 139:323e7-334e7.
13. Rivera C.A., Adegboyega P., van Rooijen N., et al. Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis. Journal of Hepatology 2007, 47:571-579.
14. Kamari Y., Shaish A., Vax E., et al. Lack of interleukin-1alpha or interleukin-1beta inhibits transformation of steatosis to steatohepatitis and liver fibrosis in hypercholesterolemic mice. Journal of Hepatology 2011, 55:1086-1094.
15. Horai R., Asano M., Sudo K., et al. Production of mice deficient in genes for interleukin (IL)-1alpha, IL-1beta, IL-1alpha/beta, and IL-1 receptor antagonist shows that IL-1beta is crucial in turpentine-induced fever development and glucocorticoid secretion. Journal of Experimental Medicine 1998, 187:1463-1475.
16. Glaccum M.B., Stocking K.L., Charrier K., et al. Phenotypic and functional characterization of mice that lack the type I receptor for IL-1. Journal of Immunology 1997, 159:3364-3371.
17. Aparicio-Vergara M., Shiri-Sverdlov R., de Haan G., et al. Bone marrow transplantation in mice as a tool for studying the role of hematopoietic cells in metabolic and cardiovascular diseases. Atherosclerosis 2010, 213(2):335-344.
18. Bradshaw G., Gutierrez A., Miyake J.H., et al. Facilitated replacement of Kupffer cells expressing a paraoxonase-1 transgene is essential for ameliorating atherosclerosis in mice. Proceedings of the National Academy of Sciences of the United States of America 2005, 102:11029-11034.
19. Folch J., Lees M., Sloane Stanley G.H. A simple method for the isolation and purification of total lipids from animal tissues. Journal of Biological Chemistry 1957, 226:497-509.
20. Stienstra R., Saudale F., Duval C., et al. Kupffer cells promote hepatic steatosis via interleukin-1beta-dependent suppression of peroxisome proliferator-activated receptor alpha activity. Hepatology 2010, 51:511-522.
21. Chen Y., Zhao L., Mei M., et al. Inflammatory stress exacerbates hepatic cholesterol accumulation via disrupting cellular cholesterol export. Journal of Gastroenterology and Hepatology 2012, 27:974-984.
22. Ma K.L., Ruan X.Z., Powis S.H., et al. Inflammatory stress exacerbates lipid accumulation in hepatic cells and fatty livers of apolipoprotein E knockout mice. Hepatology 2008, 48:770-781.
23. Prowse K.R., Baumann H. Interleukin-1 and interleukin-6 stimulate acute-phase protein production in primary mouse hepatocytes. Journal of Leukocyte Biology 1989, 45:55-61.
24. Yap S.H., Moshage H.J., Hazenberg B.P., et al. Tumor necrosis factor (TNF) inhibits interleukin (IL)-1 and/or IL-6 stimulated synthesis of C-reactive protein (CRP) and serum amyloid A (SAA) in primary cultures of human hepatocytes. Biochimica et Biophysica Acta 1991, 1091:405-408.
25. Kamari Y., Shaish A., Shemesh S., et al. Reduced atherosclerosis and inflammatory cytokines in apolipoprotein-E-deficient mice lacking bone marrow-derived interleukin-1alpha. Biochemical and Biophysical Research Communications 2011, 405:197-203.
26. Shemesh S., Kamari Y., Shaish A., et al. Interleukin-1 receptor type-1 in non-hematopoietic cells is the target for the pro-atherogenic effects of interleukin-1 in apoE-deficient mice. Atherosclerosis 2012, 222:329-336.