Antigen peptide transporter 1 is involved in the development of fructose-induced hepatic steatosis in mice

Journal of Gastroenterology and Hepatology (Australia)

Volumn 28, Issue 8, 2013, Pages 1403-1409

  Arindkar, Shailendra ^a   Bhattacharjee, Jashdeep ^a   Kumar, Jerald Mahesh ^b   Das, Barun ^a   Upadhyay, Pramod ^a   Asif, Shajahan ^a   Juyal, Ramesh C ^a   Majumdar, Subeer S ^a   Perumal, Nagarajan ^a  

^a NATIONAL INSTITUTE OF IMMUNOLOGY   (India)

^b CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

Author keywords

CD8 cells; Fructose; NAFLD; TAP1 mutant mice

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTIGEN PEPTIDE TRANSPORTER 1; ASPARTATE AMINOTRANSFERASE; BINDING PROTEIN; CARBOHYDRATE RESPONSIVE ELEMENT BINDING PROTEIN; CARRIER PROTEIN; CHOLESTEROL; FATTY ACID SYNTHASE; FRUCTOSE; GLUCOSE; GLUCOSE 6 PHOSPHATASE; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MONOCYTE CHEMOTACTIC PROTEIN 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BODY WEIGHT; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL SURFACE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; FLUORESCENCE ACTIVATED CELL SORTING; GENE EXPRESSION PROFILING; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; HISTOPATHOLOGY; INSULIN RESISTANCE; INSULIN TOLERANCE TEST; LIVER; LIVER CELL; LIVER HISTOLOGY; MALE; MOUSE; NONALCOHOLIC FATTY LIVER; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRIACYLGLYCEROL BLOOD LEVEL; WILD TYPE;

EID: 84880687134     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/jgh.12186     Document Type: Article

References (22)

1. Nagarajan P, Mahesh Kumar MJ, Venkatesan R, Majundar SS, Juyal RC. Genetically modified mouse models for the study of nonalcoholic fatty liver disease. World J. Gastroenterol. 2012; 18: 1141-1153.
2. Spruss A, Kanuri G, Uebel K, Bischoff SC, Bergheim I. Role of the inducible nitric oxide synthase in the onset of fructose-induced steatosis in mice. Antioxid. Redox Signal. 2011; 14: 2121-2135.
3. Thuy S, Ladurner R, Volynets V etal. Nonalcoholic fatty liver disease in humans is associated with increased plasma endotoxin and plasminogen activator inhibitor 1 concentrations and with fructose intake. J. Nutr. 2008; 138: 1452-1455.
4. Ouyang X, Cirillo P, Sautin Y etal. Fructose consumption as a risk Factor for non-alcoholic fatty liver disease. J. Hepatol. 2008; 48: 993-999.
5. Bergheim I, Weber S, Vos M etal. Antibiotics protect against fructose-induced hepatic lipid accumulation in mice: role of endotoxin. J. Hepatol. 2008; 48: 983-992.
6. Jurgens H, Haass W, Castaneda TR etal. Consuming fructose-sweetened beverages increases body adiposity in mice. Obes. Res. 2005; 13: 1146-1156.
7. London RM, George J. Pathogenesis of NASH: animal models. Clin. Liver Dis. 2007; 11: 55-74.
8. Leclercq IA. Pathogenesis of steatohepatitis: insights from the study of animal models. Acta Gastroenterol Belg. 2007; 70: 25-31.
9. Tang Y, Bian Z, Zhao L etal. Interleukin-17 exacerbates hepatic steatosis and inflammation in non-alcoholic fatty liver disease. Clin. Exp. Immunol. 2011; 166: 281-290.
10. Nishimura S, Manabe I, Nagasaki M etal. CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat. Med. 2009; 15: 914-920.
11. Ljunggren HG, Glas R, Sandberg JK, Karre K. Reactivity and specificity of CD8 cells in mice with defects in the MHC class I antigen-presenting pathway. Immunol. Rev. 1996; 151: 123-148.
12. Rock KL, Shen L. Cross-presentation: underlying mechanisms and role in immune surveillance. Immunol. Rev. 2005; 207: 166-183.
13. Xu H, Barnes GT, Yang Q etal. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J. Clin. Invest. 2003; 112: 1821-1830.
14. Cancello R, Henegar C, Viguerie N etal. Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss. Diabetes 2005; 54: 2277-2286.
15. Cancello R, Tordjman J, Poitou C etal. Increased infiltration of macrophages in omental adipose tissue is associated with marked hepatic lesions in morbid human obesity. Diabetes 2006; 55: 1554-1561.
16. Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr. Obesity is associated with macrophage accumulation in adipose tissue. J. Clin. Invest. 2003; 112: 1796-1808.
17. Hotamisligil GS. Inflammation and metabolic disorders. Nature 2006; 444: 860-867.
18. Olefsky JM, Glass CK. Macrophages, inflammation, and insulin resistance. Annu. Rev. Physiol. 2010; 72: 219-246.
19. Tajiri K, Shimizu Y. Role of NKT cells in the pathogenesis of NAFLD. Int. J. Hepatol. 2012; 2012: 850836. Epub 2012 Apr 5.
20. Brunt EM, Tiniakos DG. Histopathology of nonalcoholic fatty liver disease. World J. Gastroenterol. 2010; 16: 5286-5296.
21. Phillips JM, Parish NM, Raine T etal. Type 1 diabetes development requires both CD4+ and CD8 cells and can be reversed by non-depleting antibodies targeting both T cell populations. Rev. Diabet. Stud. 2009; 6: 97-103.
22. Miller BJ, Appel MC, O'Neil JJ, Wicker LS. Both the Lyt-2+ and L3T4+ T cell subsets are required for the transfer of diabetes in nonobese diabetic mice. J. Immunol. 1988; 140: 52-58.