Coinhibitory suppression of t cell activation by CD40 protects against obesity and adipose tissue inflammation in mice

Circulation

Volumn 129, Issue 23, 2014, Pages 2414-2425

  Wolf, Dennis ^a   Jehle, Felix ^a,c,d   Michel, Nathaly Anto ^a   Bukosza, Eva Nora ^a   Rivera, Jennifer ^c,d   Chen, Yung Chih ^c,d   Hoppe, Natalie ^a   Dufner, Bianca ^a   Rodriguez, Alexandra Ortiz ^a   Colberg, Christian ^a,c,d   Nieto, Leandro ^a   Rupprecht, Benjamin ^a   Wiedemann, Ansgar ^a   Schulte, Lisa ^a   Peikert, Alexander ^a   Bassler, Nicole ^c,d   Lozhkin, Andrey ^a   Hergeth, Sonja Patricia ^a   Stachon, Peter ^a   Hilgendorf, Ingo ^a   Willecke, Florian ^a   Von Zur Mühlen, Constantin ^a   Von Elverfeldt, Dominik ^d,f   Binder, Christoph J ^a,g   Aichele, Peter ^b   Varo, Nerea ^h   Febbraio, Mark A ^e   Libby, Peter ⁱ   Bode, Christoph ^j   Peter, Karlheinz ^c,d   Zirlik, Andreas ^a   more..

^a Atherogenesis Research Group University Heart Center   (United States)

^b Institute for Medical Microbiology and Hygiene Department of Immunology   (United States)

^c UNIVERSITY OF FREIBURG   (Germany)

^d BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^e Cellular and Molecular Metabolism   (Australia)

^f UNIVERSITY OF FREIBURG   (Germany)

^g MEDICAL UNIVERSITY OF VIENNA   (Austria)

^h UNIVERSITY OF NAVARRA   (Spain)

ⁱ BRIGHAM AND WOMEN S HOSPITAL   (United States)

^j Brigham and Women's Hospital Cardiovascular Medicine Harvard Medical School ^*

more..

Author keywords

Adipose tissue; CD40 ligand; Costimulatory and inhibitory T cell receptors; Inflammation; Obesity

Indexed keywords

C REACTIVE PROTEIN; CD40 ANTIGEN; CELL PROTEIN; CHOLESTEROL; GAMMA INTERFERON; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 6; LEPTIN; MONOCYTE CHEMOTACTIC PROTEIN 1; RAG1 PROTEIN; RNA; TRIACYLGLYCEROL;

ADIPOCYTE; ADIPOSE TISSUE; ADIPOSE TISSUE INFLAMMATION; ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY TITER; ANTIGEN EXPRESSION; ARTICLE; B LYMPHOCYTE; BODY COMPOSITION; BODY MASS; BONE MARROW TRANSPLANTATION; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL INVASION; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DISEASE ASSOCIATION; DYSLIPIDEMIA; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; GLUCOSE INFUSION; GLUCOSE TOLERANCE TEST; HISTOPATHOLOGY; HUMAN; HYPERLIPIDEMIA; HYPERTENSION; IMMUNOCOMPETENT CELL; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INFLAMMATORY CELL; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; INSULIN TOLERANCE TEST; LIPID DIET; LYMPHOCYTE; MACROPHAGE; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; MOUSE; NONALCOHOLIC FATTY LIVER; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OBESITY; OBSERVATIONAL STUDY; PHENOTYPE; PILOT STUDY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RNA ISOLATION; T LYMPHOCYTE ACTIVATION; TRIACYLGLYCEROL BLOOD LEVEL; WAIST CIRCUMFERENCE; WEIGHT GAIN; WESTERN BLOTTING;

ADIPOSE TISSUE; CD40 LIGAND; COSTIMULATORY AND INHIBITORY T-CELL RECEPTORS; INFLAMMATION; OBESITY;

ADIPOCYTES; ADIPOSE TISSUE; ADOPTIVE TRANSFER; ANIMALS; ANTIGENS, CD40; ATHEROSCLEROSIS; CD40 LIGAND; HUMANS; INFLAMMATION; INSULIN RESISTANCE; LYMPHOCYTE ACTIVATION; MALE; METABOLIC SYNDROME X; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OBESITY; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 84902241067     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.113.008055     Document Type: Article

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