Decreased nucleotide excision repair in steatotic livers associates with myeloperoxidase-immunoreactivity

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 736, Issue 1-2, 2012, Pages 75-81

  Schults, Marten A ^a   Nagle, Peter W ^a   Rensen, Sander S ^a   Godschalk, Roger W ^a   Munnia, Armelle ^b   Peluso, Marco ^b   Claessen, Sandra M ^c   Greve, Jan W ^a   Driessen, Ann ^a   Verdam, Froukje J ^a   Buurman, Wim A ^a   van Schooten, Frederik J ^a   Chiu, Roland K ^a  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^b ISPO Cancer Prevention and Research Institute   (Italy)

^c MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Chronic inflammation; Myeloperoxidase; Nonalcoholic steatohepatitis; Nucleotide excision repair; Oxidative stress

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; HISTONE H2AX; MYELOPEROXIDASE;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DNA ADDUCT; DNA DAMAGE; DNA REPAIR; ERCC1 GENE; ERCC4 GENE; ERCC5 GENE; EXCISION REPAIR; FEMALE; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; INFLAMMATION; MALE; MOLECULAR RECOGNITION; NEUTROPHIL CHEMOTAXIS; NONALCOHOLIC FATTY LIVER; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; STAINING; XPA GENE; XPC GENE;

ADULT; DNA DAMAGE; DNA REPAIR; FATTY LIVER; FEMALE; HISTONES; HUMANS; INFLAMMATION; MALE; MIDDLE AGED; NEUTROPHILS; OBESITY; OXIDATIVE STRESS; PEROXIDASE; REACTIVE OXYGEN SPECIES;

EID: 84864497351     PISSN: 00275107     EISSN: 09218262     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2011.11.001     Document Type: Article

References (49)

1. Farazi P.A., DePinho R.A. Hepatocellular carcinoma pathogenesis: from genes to environment. Nat. Rev. Cancer 2006, 6:674-687.
2. Boden G. Obesity and free fatty acids. Endocrinol. Metab. Clin. North Am. 2008, 37:635-646. viii-ix.
3. Yamaguchi K., Yang L., McCall S., Huang J., Yu X.X., Pandey S.K., Bhanot S., Monia B.P., Li Y.X., Diehl A.M. Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis. Hepatology 2007, 45:1366-1374.
4. Maher J.J., Leon P., Ryan J.C. Beyond insulin resistance: innate immunity in nonalcoholic steatohepatitis. Hepatology 2008, 48:670-678.
5. Tilg H., Hotamisligil G.S. Nonalcoholic fatty liver disease: cytokine-adipokine interplay and regulation of insulin resistance. Gastroenterology 2006, 131:934-945.
6. Bugianesi E. Non-alcoholic steatohepatitis and cancer. Clin. Liver Dis. 2007, 11:191-207. x-xi.
7. Bugianesi E., Leone N., Vanni E., Marchesini G., Brunello F., Carucci P., Musso A., De Paolis P., Capussotti L., Salizzoni M., Rizzetto M. Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma. Gastroenterology 2002, 123:134-140.
8. Ong J.P., Younossi Z.M. Is hepatocellular carcinoma part of the natural history of nonalcoholic steatohepatitis?. Gastroenterology 2002, 123:375-378.
9. Toyokuni S., Okamoto K., Yodoi J., Hiai H. Persistent oxidative stress in cancer. FEBS Lett. 1995, 358:1-3.
10. Sanchez-Perez Y., Carrasco-Legleu C., Garcia-Cuellar C., Perez-Carreon J., Hernandez-Garcia S., Salcido-Neyoy M., Aleman-Lazarini L., Villa-Trevino S. Oxidative stress in carcinogenesis. Correlation between lipid peroxidation and induction of preneoplastic lesions in rat hepatocarcinogenesis. Cancer Lett. 2005, 217:25-32.
11. Dewa Y., Nishimura J., Muguruma M., Jin M., Kawai M., Saegusa Y., Okamura T., Umemura T., Mitsumori K. Involvement of oxidative stress in hepatocellular tumor-promoting activity of oxfendazole in rats. Arch. Toxicol. 2009, 83:503-511.
12. Nishimura J., Dewa Y., Muguruma M., Kuroiwa Y., Yasuno H., Shima T., Jin M., Takahashi M., Umemura T., Mitsumori K. Effect of fenofibrate on oxidative DNA damage and on gene expression related to cell proliferation and apoptosis in rats. Toxicol. Sci. 2007, 97:44-54.
13. Maeda H., Akaike T. Nitric oxide and oxygen radicals in infection, inflammation, and cancer. Biochemistry (Mosc). 1998, 63:854-865.
14. Knaapen A.M., Gungor N., Schins R.P., Borm P.J., Van Schooten F.J. Neutrophils and respiratory tract DNA damage and mutagenesis: a review. Mutagenesis 2006, 21:225-236.
15. Klebanoff S.J. Myeloperoxidase: friend and foe. J. Leukoc. Biol. 2005, 77:598-625.
16. Davies M.J., Hawkins C.L., Pattison D.I., Rees M.D. Mammalian heme peroxidases: from molecular mechanisms to health implications. Antioxid. Redox Signal. 2008, 10:1199-1234.
17. Pattison D.I., Davies M.J. Absolute rate constants for the reaction of hypochlorous acid with protein side chains and peptide bonds. Chem. Res. Toxicol. 2001, 14:1453-1464.
18. Spencer J.P., Whiteman M., Jenner A., Halliwell B. Nitrite-induced deamination and hypochlorite-induced oxidation of DNA in intact human respiratory tract epithelial cells. Free Radic. Biol. Med. 2000, 28:1039-1050.
19. Rensen S.S., Slaats Y., Nijhuis J., Jans A., Bieghs V., Driessen A., Malle E., Greve J.W., Buurman W.A. Increased hepatic myeloperoxidase activity in obese subjects with nonalcoholic steatohepatitis. Am. J. Pathol. 2009, 175:1473-1482.
20. Gungor N., Godschalk R.W., Pachen D.M., Van Schooten F.J., Knaapen A.M. Activated neutrophils inhibit nucleotide excision repair in human pulmonary epithelial cells: role of myeloperoxidase. FASEB J. 2007, 21:2359-2367.
21. Gungor N., Haegens A., Knaapen A.M., Godschalk R.W., Chiu R.K., Wouters E.F., van Schooten F.J. Lung inflammation is associated with reduced pulmonary nucleotide excision repair in vivo. Mutagenesis 2010, 25:77-82.
22. Langie S.A., Kowalczyk P., Tudek B., Zabielski R., Dziaman T., Olinski R., van Schooten F.J., Godschalk R.W. The effect of oxidative stress on nucleotide-excision repair in colon tissue of newborn piglets. Mutat. Res. 2010, 695:75-80.
23. Cheng L., Spitz M.R., Hong W.K., Wei Q. Reduced expression levels of nucleotide excision repair genes in lung cancer: a case-control analysis. Carcinogenesis 2000, 21:1527-1530.
24. Latimer J.J., Johnson J.M., Kelly C.M., Miles T.D., Beaudry-Rodgers K.A., Lalanne N.A., Vogel V.G., Kanbour-Shakir A., Kelley J.L., Johnson R.R., Grant S.G. Nucleotide excision repair deficiency is intrinsic in sporadic stage I breast cancer. Proc. Natl. Acad. Sci. U. S. A. 2010, 107(50):21725-21730.
25. Lindahl T., Wood R.D. Quality control by DNA repair. Science 1999, 286:1897-1905.
26. Van Schooten F.J., Boots A.W., Knaapen A.M., Godschalk R.W., Maas L.M., Borm P.J., Drent M., Jacobs J.A. Myeloperoxidase (MPO) -463G->A reduces MPO activity and DNA adduct levels in bronchoalveolar lavages of smokers. Cancer Epidemiol. Biomarkers Prev. 2004, 13:828-833.
27. Munnia A., Saletta F., Allione A., Piro S., Confortini M., Matullo G., Peluso M. 32P-post-labelling method improvements for aromatic compound-related molecular epidemiology studies. Mutagenesis 2007, 22:381-385.
28. Munnia A., Bonassi S., Verna A., Quaglia R., Pelucco D., Ceppi M., Neri M., Buratti M., Taioli E., Garte S., Peluso M. Bronchial malondialdehyde DNA adducts, tobacco smoking, and lung cancer. Free Radic. Biol. Med. 2006, 41:1499-1505.
29. Seto H., Seto T., Takesue T., Ikemura T. Reaction of malonaldehyde with nucleic acid. III. Studies of the fluorescent substances released by enzymatic digestion of nucleic acids modified with malonaldehyde. Chem. Pharm. Bull. (Tokyo) 1986, 34:5079-5085.
30. Langie S.A., Knaapen A.M., Brauers K.J., van Berlo D., van Schooten F.J., Godschalk R.W. Development and validation of a modified comet assay to phenotypically assess nucleotide excision repair. Mutagenesis 2006, 21:153-158.
31. Knaapen A.M., Schins R.P., Borm P.J., van Schooten F.J. Nitrite enhances neutrophil-induced DNA strand breakage in pulmonary epithelial cells by inhibition of myeloperoxidase. Carcinogenesis 2005, 26:1642-1648.
32. Coussens L.M., Werb Z. Inflammation and cancer. Nature 2002, 420:860-867.
33. Bugianesi E., Vanni E., Marchesini G. NASH and the risk of cirrhosis and hepatocellular carcinoma in type 2 diabetes. Curr. Diab. Rep. 2007, 7:175-180.
34. Powell E.E., Cooksley W.G., Hanson R., Searle J., Halliday J.W., Powell L.W. The natural history of nonalcoholic steatohepatitis: a follow-up study of forty-two patients for up to 21 years. Hepatology 1990, 11:74-80.
35. Zen Y., Katayanagi K., Tsuneyama K., Harada K., Araki I., Nakanuma Y. Hepatocellular carcinoma arising in non-alcoholic steatohepatitis. Pathol. Int. 2001, 51:127-131.
36. Marnett L.J. Lipid peroxidation-DNA damage by malondialdehyde. Mutat. Res. 1999, 424:83-95.
37. VanderVeen L.A., Hashim M.F., Shyr Y., Marnett L.J. Induction of frameshift and base pair substitution mutations by the major DNA adduct of the endogenous carcinogen malondialdehyde. Proc. Natl. Acad. Sci. U. S. A. 2003, 100:14247-14252.
38. Johnson K.A., Fink S.P., Marnett L.J. Repair of propanodeoxyguanosine by nucleotide excision repair in vivo and in vitro. J. Biol. Chem. 1997, 272:11434-11438.
39. Gillet L.C., Scharer O.D. Molecular mechanisms of mammalian global genome nucleotide excision repair. Chem. Rev. 2006, 106:253-276.
40. Sancar A., Lindsey-Boltz L.A., Unsal-Kacmaz K., Linn S. Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu. Rev. Biochem 2004, 73:39-85.
41. Kojima H., Sakurai S., Uemura M., Fukui H., Morimoto H., Tamagawa Y. Mitochondrial abnormality and oxidative stress in nonalcoholic steatohepatitis. Alcohol. Clin. Exp. Res. 2007, 31:S61-S66.
42. Loguercio C., De Girolamo V., de Sio I., Tuccillo C., Ascione A., Baldi F., Budillon G., Cimino L., Di Carlo A., Di Marino M.P., Morisco F., Picciotto F., Terracciano L., Vecchione R., Verde V., Del Vecchio Blanco C. Non-alcoholic fatty liver disease in an area of southern Italy: main clinical, histological, and pathophysiological aspects. J. Hepatol. 2001, 35:568-574.
43. Seki S., Kitada T., Yamada T., Sakaguchi H., Nakatani K., Wakasa K. In situ detection of lipid peroxidation and oxidative DNA damage in non-alcoholic fatty liver diseases. J. Hepatol. 2002, 37:56-62.
44. Rogakou E.P., Pilch D.R., Orr A.H., Ivanova V.S., Bonner W.M. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J. Biol. Chem. 1998, 273:5858-5868.
45. Chen H.T., Bhandoola A., Difilippantonio M.J., Zhu J., Brown M.J., Tai X., Rogakou E.P., Brotz T.M., Bonner W.M., Ried T., Nussenzweig A. Response to RAG-mediated VDJ cleavage by NBS1 and gamma-H2AX. Science 2000, 290:1962-1965.
46. Gagou M.E., Zuazua-Villar P., Meuth M. Enhanced H2AX phosphorylation, DNA replication fork arrest, and cell death in the absence of Chk1. Mol. Biol. Cell 2010, 21:739-752.
47. Marti T.M, Hefner E., Feeney L., Natale V., Cleaver J.E. H2AX phosphorylation within the G1 phase after UV irradiation depends on nucleotide excision repair and not DNA double-strand breaks. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:9891-9896.
48. Ward I.M., Chen J. Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress. J. Biol. Chem. 2001, 276:47759-47762.
49. Machado M.V., Cortez-Pinto H. Cell death and nonalcoholic steatohepatitis: where is ballooning relevant?. Expert Rev. Gastroenterol. Hepatol. 2011, 5:213-222.