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Volumn 83, Issue 2, 2006, Pages

Obesity and the role of adipose tissue in inflammation and metabolism

Author keywords

Adiponectin; Adipose tissue; BMI; Body mass index; Exercise; Hypercholesterolemia; Hypertension; Hypertriglyceridemia; Leptin; Obesity; Stroke; Thiazolidinediones

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ADIPONECTIN; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; LEPTIN; LIPID; ROSIGLITAZONE;

EID: 33644856005     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/83.2.461s     Document Type: Conference Paper
Times cited : (1033)

References (69)
  • 1
    • 58049106258 scopus 로고    scopus 로고
    • Internet: (accessed 3 January 2005)
    • World Health Organization. Fact sheet: obesity and overweight. Internet: http://www.who.int/dietphysicalactivity/publications/facts/obesity/en/ (accessed 3 January 2005).
    • Fact Sheet: Obesity and Overweight
  • 2
    • 0037223174 scopus 로고    scopus 로고
    • Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001
    • Mokdad AH, Ford ES, Bowman BA, et al. Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. JAMA 2003;289:76-9.
    • (2003) JAMA , vol.289 , pp. 76-79
    • Mokdad, A.H.1    Ford, E.S.2    Bowman, B.A.3
  • 3
    • 0033965557 scopus 로고    scopus 로고
    • Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice
    • Gavrilova O, Marcus-Samuels B, Graham D, et al. Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice. J Clin Invest 2000;105:271-8.
    • (2000) J Clin Invest , vol.105 , pp. 271-278
    • Gavrilova, O.1    Marcus-Samuels, B.2    Graham, D.3
  • 4
    • 0033517284 scopus 로고    scopus 로고
    • Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy
    • Shimomura I, Hammer RE, Ikemoto S, Brown MS, Goldstein JL. Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy. Nature 1999;401:73-6.
    • (1999) Nature , vol.401 , pp. 73-76
    • Shimomura, I.1    Hammer, R.E.2    Ikemoto, S.3    Brown, M.S.4    Goldstein, J.L.5
  • 5
    • 0035852760 scopus 로고    scopus 로고
    • Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice
    • Fruebis J, Tsao TS, Javorschi S, et al. Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proc Natl Acad Sci U S A 2001;98:2005-10.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 2005-2010
    • Fruebis, J.1    Tsao, T.S.2    Javorschi, S.3
  • 6
    • 17944365228 scopus 로고    scopus 로고
    • The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
    • Yamauchi T, Kamon J, Waki H, et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 2001;7:941-6.
    • (2001) Nat Med , vol.7 , pp. 941-946
    • Yamauchi, T.1    Kamon, J.2    Waki, H.3
  • 7
  • 8
    • 0033515761 scopus 로고    scopus 로고
    • Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity
    • Arita Y, Kihara S, Ouchi N, et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 1999;257:79-83.
    • (1999) Biochem Biophys Res Commun , vol.257 , pp. 79-83
    • Arita, Y.1    Kihara, S.2    Ouchi, N.3
  • 9
    • 0034096988 scopus 로고    scopus 로고
    • Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients
    • Hotta K, Funahashi T, Arita Y, et al. Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Biol 2000;20:1595-9.
    • (2000) Arterioscler Thromb Vasc Biol , vol.20 , pp. 1595-1599
    • Hotta, K.1    Funahashi, T.2    Arita, Y.3
  • 10
    • 0035039227 scopus 로고    scopus 로고
    • Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys
    • Hotta K, Funahashi T, Bodkin NL, et al. Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys. Diabetes 2001;50:1126-33.
    • (2001) Diabetes , vol.50 , pp. 1126-1133
    • Hotta, K.1    Funahashi, T.2    Bodkin, N.L.3
  • 12
    • 0036061598 scopus 로고    scopus 로고
    • Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population
    • Hara K, Boutin P, Mori Y, et al. Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population. Diabetes 2002;51:536-40.
    • (2002) Diabetes , vol.51 , pp. 536-540
    • Hara, K.1    Boutin, P.2    Mori, Y.3
  • 13
    • 0033924289 scopus 로고    scopus 로고
    • Genomic structure and mutations in adipose-specific gene, adiponectin
    • Takahashi M, Arita Y, Yamagata K, et al. Genomic structure and mutations in adipose-specific gene, adiponectin. Int J Obes Relat Metab Disord 2000;24:861-8.
    • (2000) Int J Obes Relat Metab Disord , vol.24 , pp. 861-868
    • Takahashi, M.1    Arita, Y.2    Yamagata, K.3
  • 14
    • 14344273991 scopus 로고    scopus 로고
    • Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome
    • Kissebah AH, Sonnenberg GE, Myklebust J, et al. Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome. Proc Natl Acad Sci U S A 2000;97:14478-83.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 14478-14483
    • Kissebah, A.H.1    Sonnenberg, G.E.2    Myklebust, J.3
  • 15
    • 0033613545 scopus 로고    scopus 로고
    • Novel modulator for endothelial adhesion molecules: Adipocyte-derived plasma protein adiponectin
    • Ouchi N, Kihara S, Arita Y, et al. Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin. Circulation 1999;100:2473-6.
    • (1999) Circulation , vol.100 , pp. 2473-2476
    • Ouchi, N.1    Kihara, S.2    Arita, Y.3
  • 16
    • 0035957040 scopus 로고    scopus 로고
    • Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages
    • Ouchi N, Kihara S, Arita Y, et al. Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages. Circulation 2001;103:1057-63.
    • (2001) Circulation , vol.103 , pp. 1057-1063
    • Ouchi, N.1    Kihara, S.2    Arita, Y.3
  • 17
    • 0037180472 scopus 로고    scopus 로고
    • Adiponectin reduces atherosclerosis in apolipoprotein E-deficient mice
    • Okamoto Y, Kihara S, Ouchi N, et al. Adiponectin reduces atherosclerosis in apolipoprotein E-deficient mice. Circulation 2002;106:2767-70.
    • (2002) Circulation , vol.106 , pp. 2767-2770
    • Okamoto, Y.1    Kihara, S.2    Ouchi, N.3
  • 18
    • 0029073613 scopus 로고
    • Weight-reducing effects of the plasma protein encoded by the obese gene
    • Halaas JL, Gajiwala KS, Maffei M, et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 1995;269:543-6.
    • (1995) Science , vol.269 , pp. 543-546
    • Halaas, J.L.1    Gajiwala, K.S.2    Maffei, M.3
  • 19
    • 0030039272 scopus 로고    scopus 로고
    • Abnormal splicing of the leptin receptor in diabetic mice
    • Lee GH, Proenca R, Montez JM, et al. Abnormal splicing of the leptin receptor in diabetic mice. Nature 1996;379:632-5.
    • (1996) Nature , vol.379 , pp. 632-635
    • Lee, G.H.1    Proenca, R.2    Montez, J.M.3
  • 20
    • 0028845877 scopus 로고
    • Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
    • Maffei M, Halaas J, Ravussin E, et al. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 1995;1:1155-61.
    • (1995) Nat Med , vol.1 , pp. 1155-1161
    • Maffei, M.1    Halaas, J.2    Ravussin, E.3
  • 21
    • 0029066265 scopus 로고
    • Effects of the obese gene product on body weight regulation in ob/ob mice
    • Pelleymounter MA, Cullen MJ, Baker MB, et al. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 1995;269:540-3.
    • (1995) Science , vol.269 , pp. 540-543
    • Pelleymounter, M.A.1    Cullen, M.J.2    Baker, M.B.3
  • 22
    • 0030028959 scopus 로고    scopus 로고
    • Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor
    • Chua SC Jr, Chung WK, Wu-Peng XS, et al. Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science 1996;271:994-6.
    • (1996) Science , vol.271 , pp. 994-996
    • Chua Jr., S.C.1    Chung, W.K.2    Wu-Peng, X.S.3
  • 23
    • 0030878110 scopus 로고    scopus 로고
    • Congenital leptin deficiency is associated with severe early-onset obesity in humans
    • Montague CT, Farooqi IS, Whitehead JP, et al. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 1997;387:903-8.
    • (1997) Nature , vol.387 , pp. 903-908
    • Montague, C.T.1    Farooqi, I.S.2    Whitehead, J.P.3
  • 24
    • 0035514934 scopus 로고    scopus 로고
    • Partial leptin deficiency and human adiposity
    • Farooqi IS, Keogh JM, Kamath S, et al. Partial leptin deficiency and human adiposity. Nature 2001;414:34-5.
    • (2001) Nature , vol.414 , pp. 34-35
    • Farooqi, I.S.1    Keogh, J.M.2    Kamath, S.3
  • 25
    • 0344450708 scopus 로고    scopus 로고
    • A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
    • Clement K, Vaisse C, Lahlou N, et al. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 1998;392:398-401.
    • (1998) Nature , vol.392 , pp. 398-401
    • Clement, K.1    Vaisse, C.2    Lahlou, N.3
  • 26
    • 0036800760 scopus 로고    scopus 로고
    • Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency
    • Farooqi IS, Matarese G, Lord GM, et al. Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J Clin Invest 2002;110:1093-103.
    • (2002) J Clin Invest , vol.110 , pp. 1093-1103
    • Farooqi, I.S.1    Matarese, G.2    Lord, G.M.3
  • 27
    • 0033575993 scopus 로고    scopus 로고
    • Effects of recombinant leptin therapy in a child with congenital leptin deficiency
    • Farooqi IS, Jebb SA, Langmack G, et al. Effects of recombinant leptin therapy in a child with congenital leptin deficiency. N Engl J Med 1999;341:879-84.
    • (1999) N Engl J Med , vol.341 , pp. 879-884
    • Farooqi, I.S.1    Jebb, S.A.2    Langmack, G.3
  • 28
    • 13344295079 scopus 로고    scopus 로고
    • Serum immunoreactiveleptin concentrations in normal-weight and obese humans
    • Considine RV, Sinha MK, Heiman ML, et al. Serum immunoreactiveleptin concentrations in normal-weight and obese humans. N Engl J Med 1996;334:292-5.
    • (1996) N Engl J Med , vol.334 , pp. 292-295
    • Considine, R.V.1    Sinha, M.K.2    Heiman, M.L.3
  • 29
    • 9244219587 scopus 로고    scopus 로고
    • Region-specific leptin resistance within the hypothalamus of diet-induced obese mice
    • Munzberg H, Flier JS, Bjorbaek C. Region-specific leptin resistance within the hypothalamus of diet-induced obese mice. Endocrinology 2004;145:4880-9.
    • (2004) Endocrinology , vol.145 , pp. 4880-4889
    • Munzberg, H.1    Flier, J.S.2    Bjorbaek, C.3
  • 30
    • 0037148928 scopus 로고    scopus 로고
    • Leptin-replacement therapy for lipodystrophy
    • Oral EA, Simha V, Ruiz E, et al. Leptin-replacement therapy for lipodystrophy. N Engl J Med 2002;346:570-8.
    • (2002) N Engl J Med , vol.346 , pp. 570-578
    • Oral, E.A.1    Simha, V.2    Ruiz, E.3
  • 31
    • 0036851817 scopus 로고    scopus 로고
    • Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
    • Yamauchi T, Kamon J, Minokoshi Y, et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med 2002;8:1288-95.
    • (2002) Nat Med , vol.8 , pp. 1288-1295
    • Yamauchi, T.1    Kamon, J.2    Minokoshi, Y.3
  • 32
    • 0037329602 scopus 로고    scopus 로고
    • Role of AMP-activated protein kinase in leptininduced fatty acid oxidation in muscle
    • Minokoshi Y, Kahn BB. Role of AMP-activated protein kinase in leptininduced fatty acid oxidation in muscle. Biochem Soc Trans 2003;31:196-201.
    • (2003) Biochem Soc Trans , vol.31 , pp. 196-201
    • Minokoshi, Y.1    Kahn, B.B.2
  • 33
    • 3843061592 scopus 로고    scopus 로고
    • AMP kinase and malonyl-CoA: Targets for therapy of the metabolic syndrome
    • Ruderman N, Prentki M. AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndrome. Nat Rev Drug Discov 2004;3:340-51.
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 340-351
    • Ruderman, N.1    Prentki, M.2
  • 34
    • 0033939021 scopus 로고    scopus 로고
    • Whole body and abdominal lipolytic sensitivity to epinephrine is suppressed in upper body obese women
    • Horowitz JF, Klein S. Whole body and abdominal lipolytic sensitivity to epinephrine is suppressed in upper body obese women. Am J Physiol Endocrinol Metab 2000;278:E1144-52.
    • (2000) Am J Physiol Endocrinol Metab , vol.278
    • Horowitz, J.F.1    Klein, S.2
  • 36
    • 0033927667 scopus 로고    scopus 로고
    • Cellular mechanisms of insulin resistance
    • Shulman GI. Cellular mechanisms of insulin resistance. J Clin Invest 2000;106:171-6.
    • (2000) J Clin Invest , vol.106 , pp. 171-176
    • Shulman, G.I.1
  • 37
    • 0347065339 scopus 로고    scopus 로고
    • Lipase-selective functional domains of perilipin A differentially regulate constitutive and protein kinase A-stimulated lipolysis
    • Zhang HH, Souza SC, Muliro KV, Kraemer FB, Obin MS, Greenberg AS. Lipase-selective functional domains of perilipin A differentially regulate constitutive and protein kinase A-stimulated lipolysis. J Biol Chem 2003;278:51535-42.
    • (2003) J Biol Chem , vol.278 , pp. 51535-51542
    • Zhang, H.H.1    Souza, S.C.2    Muliro, K.V.3    Kraemer, F.B.4    Obin, M.S.5    Greenberg, A.S.6
  • 38
    • 1542341626 scopus 로고    scopus 로고
    • Perilipin expression in human adipose tissues: Effects of severe obesity, gender, and depot
    • Wang Y, Sullivan S, Trujillo M, et al. Perilipin expression in human adipose tissues: effects of severe obesity, gender, and depot. Obes Res 2003;11:930-6.
    • (2003) Obes Res , vol.11 , pp. 930-936
    • Wang, Y.1    Sullivan, S.2    Trujillo, M.3
  • 39
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance
    • Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 1993;259:87-91.
    • (1993) Science , vol.259 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 41
    • 0034770292 scopus 로고    scopus 로고
    • Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle
    • Perreault M, Marette A. Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle. Nat Med 2001;7:1138-43.
    • (2001) Nat Med , vol.7 , pp. 1138-1143
    • Perreault, M.1    Marette, A.2
  • 42
    • 0031000588 scopus 로고    scopus 로고
    • Elevated expression of transforming growth factor-beta in adipose tissue from obese mice
    • Samad F, Yamamoto K, Pandey M, Loskutoff DJ. Elevated expression of transforming growth factor-beta in adipose tissue from obese mice. Mol Med 1997;3:37-48.
    • (1997) Mol Med , vol.3 , pp. 37-48
    • Samad, F.1    Yamamoto, K.2    Pandey, M.3    Loskutoff, D.J.4
  • 43
    • 0033537013 scopus 로고    scopus 로고
    • Elevated C-reactive protein levels in overweight and obese adults
    • Visser M, Bouter LM, McQuillan GM, Wener MH, Harris TB. Elevated C-reactive protein levels in overweight and obese adults. JAMA 1999;282:2131-5.
    • (1999) JAMA , vol.282 , pp. 2131-2135
    • Visser, M.1    Bouter, L.M.2    McQuillan, G.M.3    Wener, M.H.4    Harris, T.B.5
  • 44
    • 0036186652 scopus 로고    scopus 로고
    • Humoral markers of inflammation and endothelial dysfunction in relation to adiposity and in vivo insulin action in Pima Indians
    • Weyer C, Yudkin JS, Stehouwer CD, Schalkwijk CG, Pratley RE, Tataranni PA. Humoral markers of inflammation and endothelial dysfunction in relation to adiposity and in vivo insulin action in Pima Indians. Atherosclerosis 2002;161:233-42.
    • (2002) Atherosclerosis , vol.161 , pp. 233-242
    • Weyer, C.1    Yudkin, J.S.2    Stehouwer, C.D.3    Schalkwijk, C.G.4    Pratley, R.E.5    Tataranni, P.A.6
  • 45
    • 0038809142 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein 1 in obesity and insulin resistance
    • Sartipy P, Loskutoff DJ. Monocyte chemoattractant protein 1 in obesity and insulin resistance. Proc Natl Acad Sci U S A 2003;100:7265-70.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 7265-7270
    • Sartipy, P.1    Loskutoff, D.J.2
  • 46
    • 0030050952 scopus 로고    scopus 로고
    • Distribution and regulation of plasminogen activator inhibitor-1 in murine adipose tissue in vivo. Induction by tumor necrosis factor-alpha and lipopolysaccharide
    • Samad F, Yamamoto K, Loskutoff DJ. Distribution and regulation of plasminogen activator inhibitor-1 in murine adipose tissue in vivo. Induction by tumor necrosis factor-alpha and lipopolysaccharide. J Clin Invest 1996;97:37-46.
    • (1996) J Clin Invest , vol.97 , pp. 37-46
    • Samad, F.1    Yamamoto, K.2    Loskutoff, D.J.3
  • 47
    • 0032560479 scopus 로고    scopus 로고
    • Tissue factor gene expression in the adipose tissues of obese mice
    • Samad F, Pandey M, Loskutoff DJ. Tissue factor gene expression in the adipose tissues of obese mice. Proc Natl Acad Sci U S A 1998;95:7591-6.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 7591-7596
    • Samad, F.1    Pandey, M.2    Loskutoff, D.J.3
  • 48
    • 0036862025 scopus 로고    scopus 로고
    • Coagulation and fibrinolysis abnormalities in obesity
    • De Pergola G, Pannacciulli N. Coagulation and fibrinolysis abnormalities in obesity. J Endocrinol Invest 2002;25:899-904.
    • (2002) J Endocrinol Invest , vol.25 , pp. 899-904
    • De Pergola, G.1    Pannacciulli, N.2
  • 49
    • 0031762908 scopus 로고    scopus 로고
    • Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: Depot difference and regulation by glucocorticoid
    • Fried SK, Bunkin DA, Greenberg AS. Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid. J Clin Endocrinol Metab 1998;83:847-50.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 847-850
    • Fried, S.K.1    Bunkin, D.A.2    Greenberg, A.S.3
  • 51
    • 9144223683 scopus 로고    scopus 로고
    • Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
    • Xu H, Barnes GT, Yang Q, et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 2003;112:1821-30.
    • (2003) J Clin Invest , vol.112 , pp. 1821-1830
    • Xu, H.1    Barnes, G.T.2    Yang, Q.3
  • 52
    • 27444437321 scopus 로고    scopus 로고
    • Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans
    • Cinti S, Mitchell G, Barbatelli G, et al. Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J Lipid Res 2005;46:2347-55.
    • (2005) J Lipid Res , vol.46 , pp. 2347-2355
    • Cinti, S.1    Mitchell, G.2    Barbatelli, G.3
  • 53
    • 0042466384 scopus 로고    scopus 로고
    • Regulation of adiponectin by adipose tissue-derived cytokines: In vivo and in vitro investigations in humans
    • Bruun JM, Lihn AS, Verdich C, et al. Regulation of adiponectin by adipose tissue-derived cytokines: in vivo and in vitro investigations in humans. Am J Physiol Endocrinol Metab 2003;285:E527-33.
    • (2003) Am J Physiol Endocrinol Metab , vol.285
    • Bruun, J.M.1    Lihn, A.S.2    Verdich, C.3
  • 54
    • 0028587742 scopus 로고
    • Tumor necrosis factor alpha: A key component of the obesity-diabetes link
    • Hotamisligil GS, Spiegelman BM. Tumor necrosis factor alpha: a key component of the obesity-diabetes link. Diabetes 1994;43:1271-8.
    • (1994) Diabetes , vol.43 , pp. 1271-1278
    • Hotamisligil, G.S.1    Spiegelman, B.M.2
  • 55
    • 0035023128 scopus 로고    scopus 로고
    • Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance
    • Kern PA, Ranganathan S, Li C, Wood L, Ranganathan G. Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance. Am J Physiol Endocrinol Metab 2001;280:E745-51.
    • (2001) Am J Physiol Endocrinol Metab , vol.280
    • Kern, P.A.1    Ranganathan, S.2    Li, C.3    Wood, L.4    Ranganathan, G.5
  • 56
    • 0036789186 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha stimulates lipolysis in differentiated human adipocytes through activation of extracellular signal-related kinase and elevation of intracellular cAMP
    • Zhang HH, Halbleib M, Ahmad F, Manganiello VC, Greenberg AS. Tumor necrosis factor-alpha stimulates lipolysis in differentiated human adipocytes through activation of extracellular signal-related kinase and elevation of intracellular cAMP. Diabetes 2002;51:2929-35.
    • (2002) Diabetes , vol.51 , pp. 2929-2935
    • Zhang, H.H.1    Halbleib, M.2    Ahmad, F.3    Manganiello, V.C.4    Greenberg, A.S.5
  • 57
    • 0041568670 scopus 로고    scopus 로고
    • TNF-alpha induction of lipolysis is mediated through activation of the extracellular signal related kinase pathway in 3T3-L1 adipocytes
    • Souza SC, Palmer HJ, Kang YH, et al. TNF-alpha induction of lipolysis is mediated through activation of the extracellular signal related kinase pathway in 3T3-L1 adipocytes. J Cell Biochem 2003;89:1077-86.
    • (2003) J Cell Biochem , vol.89 , pp. 1077-1086
    • Souza, S.C.1    Palmer, H.J.2    Kang, Y.H.3
  • 58
    • 0030735542 scopus 로고    scopus 로고
    • Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo
    • Mohamed-Ali V, Goodrick S, Rawesh A, et al. Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo. J Clin Endocrinol Metab 1997;82:4196-200.
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 4196-4200
    • Mohamed-Ali, V.1    Goodrick, S.2    Rawesh, A.3
  • 59
    • 0038372035 scopus 로고    scopus 로고
    • Interleukin-6 stimulates lipolysis and fat oxidation in humans
    • van Hall G, Steensberg A, Sacchetti M, et al. Interleukin-6 stimulates lipolysis and fat oxidation in humans. J Clin Endocrinol Metab 2003;88:3005-10.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 3005-3010
    • Van Hall, G.1    Steensberg, A.2    Sacchetti, M.3
  • 60
    • 0242268894 scopus 로고    scopus 로고
    • Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice
    • Klover PJ, Zimmers TA, Koniaris LG, Mooney RA. Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice. Diabetes 2003;52:2784-9.
    • (2003) Diabetes , vol.52 , pp. 2784-2789
    • Klover, P.J.1    Zimmers, T.A.2    Koniaris, L.G.3    Mooney, R.A.4
  • 61
    • 0035908632 scopus 로고    scopus 로고
    • C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus
    • Pradhan AD, Manson JE, Rifai N, Buring JE, Ridker PM. C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA 2001;286:327-34.
    • (2001) JAMA , vol.286 , pp. 327-334
    • Pradhan, A.D.1    Manson, J.E.2    Rifai, N.3    Buring, J.E.4    Ridker, P.M.5
  • 62
    • 0034681920 scopus 로고    scopus 로고
    • Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men
    • Ridker PM, Rifai N, Stampfer MJ, Hennekens CH. Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men. Circulation 2000;101:1767-72.
    • (2000) Circulation , vol.101 , pp. 1767-1772
    • Ridker, P.M.1    Rifai, N.2    Stampfer, M.J.3    Hennekens, C.H.4
  • 63
    • 1542722295 scopus 로고    scopus 로고
    • 11-beta-Hydroxysteroid dehydrogenase type 1 in obesity and the metabolic syndrome
    • Wake DJ, Walker BR. 11-beta-Hydroxysteroid dehydrogenase type 1 in obesity and the metabolic syndrome. Mol Cell Endocrinol 2004;215:45-54.
    • (2004) Mol Cell Endocrinol , vol.215 , pp. 45-54
    • Wake, D.J.1    Walker, B.R.2
  • 64
    • 0035824440 scopus 로고    scopus 로고
    • A transgenic model of visceral obesity and the metabolic syndrome
    • Masuzaki H, Paterson J, Shinyama H, et al. A transgenic model of visceral obesity and the metabolic syndrome. Science 2001;294:2166-70.
    • (2001) Science , vol.294 , pp. 2166-2170
    • Masuzaki, H.1    Paterson, J.2    Shinyama, H.3
  • 65
    • 0031898610 scopus 로고    scopus 로고
    • PPAR-gamma: Adipogenic regulator and thiazolidinedione receptor
    • Spiegelman BM. PPAR-gamma: adipogenic regulator and thiazolidinedione receptor. Diabetes 1998;47:507-14.
    • (1998) Diabetes , vol.47 , pp. 507-514
    • Spiegelman, B.M.1
  • 66
    • 0029894050 scopus 로고    scopus 로고
    • Antidiabetic thiazolidinediones inhibit leptin (ob) gene expression in 3T3-L1 adipocytes
    • Kallen CB, Lazar MA. Antidiabetic thiazolidinediones inhibit leptin (ob) gene expression in 3T3-L1 adipocytes. Proc Natl Acad Sci U S A 1996;93:5793-6.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 5793-5796
    • Kallen, C.B.1    Lazar, M.A.2
  • 67
    • 0142093012 scopus 로고    scopus 로고
    • The expanding scope of the metabolic syndrome and implications for the management of cardiovascular risk in type 2 diabetes with particular focus on the emerging role of the thiazolidinediones
    • Greenberg AS. The expanding scope of the metabolic syndrome and implications for the management of cardiovascular risk in type 2 diabetes with particular focus on the emerging role of the thiazolidinediones. J Diabetes Complications 2003;17:218-28.
    • (2003) J Diabetes Complications , vol.17 , pp. 218-228
    • Greenberg, A.S.1
  • 68
    • 0037067666 scopus 로고    scopus 로고
    • The anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways
    • Fryer LG, Parbu-Patel A, Carling D. The anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways. J Biol Chem 2002;277:25226-32.
    • (2002) J Biol Chem , vol.277 , pp. 25226-25232
    • Fryer, L.G.1    Parbu-Patel, A.2    Carling, D.3
  • 69
    • 3242745192 scopus 로고    scopus 로고
    • Effects of rosiglitazone and metformin on liver fat content, hepatic insulin resistance, insulin clearance, and gene expression in adipose tissue in patients with type 2 diabetes
    • Tiikkainen M, Hakkinen AM, Korsheninnikova E, Nyman T, Makimattila S, Yki-Jarvinen H. Effects of rosiglitazone and metformin on liver fat content, hepatic insulin resistance, insulin clearance, and gene expression in adipose tissue in patients with type 2 diabetes. Diabetes 2004;53:2169-76.
    • (2004) Diabetes , vol.53 , pp. 2169-2176
    • Tiikkainen, M.1    Hakkinen, A.M.2    Korsheninnikova, E.3    Nyman, T.4    Makimattila, S.5    Yki-Jarvinen, H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.