Blocking CD40-TRAF6 interactions by small-molecule inhibitor 6860766 ameliorates the complications of diet-induced obesity in mice

International Journal of Obesity

Volumn 39, Issue 5, 2015, Pages 782-790

  Van Den Berg, S M ^a   Seijkens, T T P ^a   Kusters, P J H ^a   Zarzycka, B ^b   Beckers, L ^a   Den Toom, M ^a   Gijbels, M J J ^a,b   Chatzigeorgiou, A ^c   Weber, C ^b,d   De Winther, M P J ^a   Chavakis, T ^c   Nicolaes, G A F ^b   Lutgens, E ^a,d  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

^c DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^d LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 ANTIGEN; PROTEIN INHIBITOR; SMALL MOLECULE TRANSPORT AGENT; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; ANILINE DERIVATIVE; PROPIOPHENONE DERIVATIVE; SMI 6860766;

ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL COUNT; CONTROLLED STUDY; DIET INDUCED OBESITY; DRUG PROTEIN BINDING; DRUG STRUCTURE; EPIDIDYMIS FAT; FATTY LIVER; GLUCOSE TOLERANCE; IC50; IN VITRO STUDY; INFLAMMATION; INSULIN RESISTANCE; MACROPHAGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; WEIGHT GAIN; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL CULTURE; COMPLICATION; DRUG EFFECTS; FLOW CYTOMETRY; LIPID DIET; METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; SIGNAL TRANSDUCTION;

MUS;

ADIPOSE TISSUE; ANILINE COMPOUNDS; ANIMALS; ANTIGENS, CD40; CD8-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; DIABETES MELLITUS, TYPE 2; DIET, HIGH-FAT; FLOW CYTOMETRY; INFLAMMATION; INSULIN RESISTANCE; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; OBESITY; PROPIOPHENONES; SIGNAL TRANSDUCTION; TNF RECEPTOR-ASSOCIATED FACTOR 6;

EID: 84928925813     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/ijo.2014.198     Document Type: Article

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