Interleukin-17 exacerbates hepatic steatosis and inflammation in non-alcoholic fatty liver disease

Clinical and Experimental Immunology

Volumn 166, Issue 2, 2011, Pages 281-290

  Tang, Y ^a   Bian, Z ^a   Zhao, L ^a   Liu, Y ^a   Liang, S ^b   Wang, Q ^a   Han, X ^a   Peng, Y ^a   Chen, X ^a   Shen, L ^a   Qiu, D ^a   Li, Z ^b   Ma, X ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Inflammation; Insulin resistance; Non alcoholic steatohepatitis; Signalling pathways; Th17 cells

Indexed keywords

ALANINE AMINOTRANSFERASE; INSULIN; INTERLEUKIN 17; INTERLEUKIN 21; INTERLEUKIN 23; LIPOPOLYSACCHARIDE; OLEIC ACID; PALMITIC ACID; RETINOID RELATED ORPHAN RECEPTOR GAMMA; TRANSFORMING GROWTH FACTOR BETA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; C57BL 6 MOUSE; CELL CULTURE; CELL INFILTRATION; CELL STRAIN HEPG2; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIET; DISEASE COURSE; DISEASE EXACERBATION; DISEASE MODEL; FATTY LIVER; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; INFLAMMATION; INFLAMMATORY INFILTRATE; INTRACELLULAR SIGNALING; LIVER CELL; LIVER INJURY; MALE; MOUSE; NONALCOHOLIC FATTY LIVER; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; TH17 CELL;

ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; CELLS, CULTURED; DIET, HIGH-FAT; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FATTY ACIDS; FATTY LIVER; GENE EXPRESSION REGULATION; HEP G2 CELLS; HEPATOCYTES; HUMANS; INSULIN; INTERLEUKIN-17; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; LIVER; MALE; MICE; MICE, INBRED C57BL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, REGULATORY; TH17 CELLS; TRANSFORMING GROWTH FACTOR BETA;

EID: 80053651902     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2011.04471.x     Document Type: Article

References (39)

1. Farrell GC, Larter CZ. Nonalcoholic fatty liver disease: from steatosis to cirrhosis. Hepatology 2006; 43 (Suppl. 1):S99-S112.
2. Kleiner DE, Brunt EM, Van Natta M etal. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005; 41:1313-21.
3. Brunt EM. Nonalcoholic steatohepatitis. Semin Liver Dis 2004; 24:3-20.
4. Cortez-Pinto H, de Moura MC, Day CP. Non-alcoholic steatohepatitis: from cell biology to clinical practice. J Hepatol 2006; 44:197-208.
5. Kremer M, Hines IN, Milton RJ, Wheeler MD. Favored T helper 1 response in a mouse model of hepatosteatosis is associated with enhanced T cell-mediated hepatitis. Hepatology 2006; 44:216-27.
6. Langrish CL, Chen Y, Blumenschein WM etal. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med 2005; 201:233-40.
7. Park H, Li Z, Yang XO etal. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 2005; 6:1133-41.
8. Harrington LE, Hatton RD, Mangan PR etal. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 2005; 6:1123-32.
9. Korn T, Bettelli E, Oukka M, Kuchroo VK. IL-17 and Th17 Cells. Annu Rev Immunol 2009; 27:485-517.
10. Zhao L, Qiu D, Ma X. Th17 cells: the emerging reciprocal partner of regulatory T cells in the liver. J Dig Dis 2010; 11:126-33.
11. Weaver CT, Hatton RD. Interplay between the TH17 and Treg cell lineages: a (co-)evolutionary perspective. Nat Rev Immunol 2009; 9:883-9.
12. Ye C, Li WY, Zheng MH, Chen YP. T-helper 17 cell: a distinctive cell in liver diseases. Hepatol Res 2011; 41:22-9.
13. Hammerich L, Heymann F, Tacke F. Role of IL-17 and Th17 cells in liver diseases. Clin Dev Immunol 2011; Article ID 345803, 12 pages.
14. Ma X, Hua J, Mohamood AR, Hamad AR, Ravi R, Li Z. A high-fat diet and regulatory T cells influence susceptibility to endotoxin-induced liver injury. Hepatology 2007; 46:1519-29.
15. Yamaguchi K, Yang L, McCall S etal. Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis. Hepatology 2007; 45:1366-74.
16. Guebre-Xabier M, Yang S, Lin HZ, Schwenk R, Krzych U, Diehl AM. Altered hepatic lymphocyte subpopulations in obesity-related murine fatty livers: potential mechanism for sensitization to liver damage. Hepatology 2000; 31:633-40.
17. Vick B, Weber A, Urbanik T etal. Knockout of myeloid cell leukemia-1 induces liver damage and increases apoptosis susceptibility of murine hepatocytes. Hepatology 2009; 49:627-36.
18. Li Z, Soloski MJ, Diehl AM. Dietary factors alter hepatic innate immune system in mice with nonalcoholic fatty liver disease. Hepatology 2005; 42:880-5.
19. Feldstein AE, Canbay A, Guicciardi ME, Higuchi H, Bronk SF, Gores GJ. Diet associated hepatic steatosis sensitizes to Fas mediated liver injury in mice. J Hepatol 2003; 39:978-83.
20. Zhou L, Ivanov II, Spolski R etal. IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol 2007; 8:967-74.
21. Mas E, Danjoux M, Garcia V, Carpentier S, Segui B, Levade T. IL-6 deficiency attenuates murine diet-induced non-alcoholic steatohepatitis. PLoS ONE 2009; 4:e7929.
22. Streetz KL, Luedde T, Manns MP, Trautwein C. Interleukin 6 and liver regeneration. Gut 2000; 47:309-12.
23. Maher JJ, Leon P, Ryan JC. Beyond insulin resistance: innate immunity in nonalcoholic steatohepatitis. Hepatology 2008; 48:670-8.
24. Ma X, Li Z. Pathogenesis of nonalcoholic steatohepatitis (NASH). Chin J Dig Dis 2006; 7:7-11.
25. Yang L, Anderson DE, Baecher-Allan C etal. IL-21 and TGF-beta are required for differentiation of human T(H)17 cells. Nature 2008; 454:350-2.
26. Manel N, Unutmaz D, Littman DR. The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat. Nat Immunol 2008; 9:641-9.
27. Miossec P, Korn T, Kuchroo VK. Interleukin-17 and type 17 helper T cells. N Engl J Med 2009; 361:888-98.
28. Wieckowska A, Papouchado BG, Li Z, Lopez R, Zein NN, Feldstein AE. Increased hepatic and circulating interleukin-6 levels in human nonalcoholic steatohepatitis. Am J Gastroenterol 2008; 103:1372-9.
29. Bettelli E, Carrier Y, Gao W etal. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006; 441:235-8.
30. Korn T, Bettelli E, Gao W etal. IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature 2007; 448:484-7.
31. Mangan PR, Harrington LE, O'Quinn DB etal. Transforming growth factor-beta induces development of the T(H)17 lineage. Nature 2006; 441:231-4.
32. Veldhoen M, Hocking RJ, Atkins CJ, Locksley RM, Stockinger B. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 2006; 24:179-89.
33. Lan RY, Salunga TL, Tsuneyama K etal. Hepatic IL-17 responses in human and murine primary biliary cirrhosis. J Autoimmun 2009; 32:43-51.
34. Rong G, Zhou Y, Xiong Y etal. Imbalance between T helper type 17 and T regulatory cells in patients with primary biliary cirrhosis: the serum cytokine profile and peripheral cell population. Clin Exp Immunol 2009; 156:217-25.
35. Zhang JY, Zhang Z, Lin F etal. Interleukin-17-producing CD4(+) T cells increase with severity of liver damage in patients with chronic hepatitis B. Hepatology 2010; 51:81-91.
36. Lemmers A, Moreno C, Gustot T etal. The interleukin-17 pathway is involved in human alcoholic liver disease. Hepatology 2009; 49:646-57.
37. Kuang DM, Peng C, Zhao Q, Wu Y, Chen MS, Zheng L. Activated monocytes in peritumoral stroma of hepatocellular carcinoma promote expansion of memory T helper 17 cells. Hepatology 2010; 51:154-64.
38. Zhou L, Lopes JE, Chong MM etal. TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. Nature 2008; 453:236-40.
39. Ichiyama K, Yoshida H, Wakabayashi Y etal. Foxp3 inhibits RORgammat-mediated IL-17A mRNA transcription through direct interaction with RORgammat. J Biol Chem 2008; 283:17003-8.