The role of TGFβ1 in initiating hepatic stellate cell activation in vivo

Journal of Hepatology

Volumn 30, Issue 1, 1999, Pages 77-87

  Hellerbrand, Claus ^a   Stefanovic, Branko ^a   Giordano, Frank ^a   Burchardt, Elmar R ^a   Brenner, David A ^a  

^a NONE

Author keywords

Adenovirus; Fibrosis; Hepatic stellate cell; Knock out

Indexed keywords

CARBON TETRACHLORIDE; COLLAGENASE; PLASMINOGEN ACTIVATOR INHIBITOR; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSFORMING GROWTH FACTOR BETA; ACTIN; COLLAGEN; GROWTH INHIBITOR; MESSENGER RNA; RECOMBINANT PROTEIN;

ADENOVIRUS; ANIMAL CELL; ARTICLE; ENZYME DEGRADATION; EXTRACELLULAR MATRIX; GENE TARGETING; IN VIVO STUDY; KNOCKOUT MOUSE; LIVER FIBROSIS; LIVER PARENCHYMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; STELLATE CELL; ANIMAL; CYTOLOGY; DRUG EFFECT; GENETIC TRANSDUCTION; GENETICS; HUMAN; LIVER; METABOLISM; MOUSE MUTANT; PHYSIOLOGY; REFERENCE VALUE; SMOOTH MUSCLE;

ACTINS; ANIMALS; CARBON TETRACHLORIDE; COLLAGEN; GROWTH INHIBITORS; HUMANS; LIVER; MICE; MICE, KNOCKOUT; MUSCLE, SMOOTH; RECOMBINANT PROTEINS; REFERENCE VALUES; RNA, MESSENGER; TRANSDUCTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA;

EID: 0032586690     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(99)80010-5     Document Type: Article

References (68)

1. Weiner FR, Giambrone MA, Czaja MJ, Shah A, Annoni G, Takahashi S, et al. Ito-cell gene expression and collagen regulation. Hepatology. 11:1990;111-117.
2. Nakatsukasa H, Nagy P, Evarts RP, Chu-Chieh H, Marsden E, Thorgeirsson SS. Cellular distribution of transforming growth factor-β1 and procollagen types 1, III, and IV transcripts in carbon tetrachloride-induced rat liver fibrosis. J Clin Invest. 85:1990;1833-1843.
3. 4 or vitamin Atreated rats. Dig Dis Sci. 32:1987;1281-1289.
4. Friedman SL. Cellular sources of collagen and regulation of collagen production in liver. Semin Liver Dis. 10:1990;20-29.
5. Friedman SL. Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. N Engl J Med. 328:1993;1828-1835.
6. Gressner AM. Mediators of hepatic fibrogenesis. Hepato-gastroenterology. 43:1996;92-103.
7. Mak KM, Leo MA, Lieber CS. Alcoholic liver injury in baboon: transformation of lipocytes to transitional cells. Gastroenterology. 87:1984;188-200.
8. Schmitt-Graff A, Chakroun G, Gabbiani G. Modulation of perisinusoidal cell cytoskeletal features during experimental hepatic fibrosis. Virchows Archiv B Cell Path. 422:1993;99-107.
9. Ogawa K, Suzuki J-I, Mukai H, Mori M. Sequential changes of extracellular matrix and proliferation of Ito cells with enhanced expression of desmin and actin in focal hepatic injury. Am J Pathol. 125:1986;611-619.
10. Ramadori G, Weit T, Schwogler S, Dienes HP, Knittel T, Rieder H, et al. Expression of the gene of the alpha-smooth muscle actin isoform in rat liver and in rat fat-storing (Ito) cells. Virchows Archiv B Cell Path. 59:1990;349-357.
11. DeLeeuw AM, McCarthy SP, Geerts A, Knook DL. Purified rat liver fat storing cells divide in culture and contain collagen. Hepatology. 4:1984;392-403.
12. Friedman SL, Rockey DC, McGuire RF, Maher JJ, Boyles JK, Yamasaki G. Isolated hepatic lipocytes and Kupffer cells from normal human liver: morphological and functional characteristics in primary culture. Hepatology. 15:1992;234-243.
13. Wong L, Yamasaki G, Johnson RJ, Friedman SL. Induction of platelet-derived growth factor receptor in rat hepatic lipocytes during cellular activation in vivo and in culture. J Clin Invest. 94:1994;1563-1569.
14. Friedman SL, Yamasaki G, Wong L. Modulation of transforming growth factor-β receptors of rat lipocytes during the hepatic wound healing response. J Biol Chem. 269:1994;10551-10558.
15. Ramm GA, Britton RS, O'Neill R, Bacon BR. Identification and characterization of a receptor for tissue ferritin on activated rat lipocytes. J Clin Invest. 94:1994;9-15.
16. de Bleser PJ, Niki T, Rogiers V, Geerts A. Transforming growth factor beta gene expression in normal and fibrotic rat liver. J Hepatol. 26:1997;886-893.
17. Bissell DM, Wang S-S, Jarnagin WR, Roll FJ. Cell-specific expression of transforming growth factor beta in rat liver. Evidence for autocrine regulation of hepatocyte proliferation. J Clin Invest. 96:1995;447-455.
18. Parola M, Muraca R, Dianzani I, Barrera G, Leonarduzzi G, Bendinelli P, et al. Vitamin E dietary supplementation inhibits transforming growth factor beta 1 gene expression in the rat liver. FEBS Lett. 308:1992;267-270.
19. Annoni G, Weiner F, Zern MA. Increased transforming growth factor betal gene expression in human liver disease. J Hepatol. 14:1992;259-264.
20. Bachem MG, Mcyer D, Melchior R, Sell KM, Gressner AM. Activation of rat liver perisinusoidal lipocytes by transforming growth factors derived from myofibroblast-like cells. A potential mechanism of self perpetuation in liver fibrogenesis. J Clin Invest. 89:1992;19-27.
21. Wrana J, Attisano L, Wieser R, Ventura F, Massague J. Mechanism of activation of the TGF beta receptor. Nature. 370:1994;341-347.
22. Padgett RW, Savage C, Das P. Genetic and biochemical analysis of TGF beta signal transduction. Cytokine Growth Factor Review. 8:1997;1-9.
23. Sanderson N, Factor V, Nagy P, Kopp J, Kondaiah P, Wakefield L, et al. Hepatic expression of mature transforming growth factor betal in transgenic mice results in multiple tissue lesions. Proc Natl Acad Sci USA. 92:1995;2572-2576.
24. Clouthier DE, Comerford SA, Hammer RE. Hepatic fibrosis, glomerulosclerosis, and a lipodystrophy-like syndrome in PEPCK-TGF betal transgenic mice. J Clin Invest. 100:1997;2697-2713.
25. Bedossa P, Paradis V. Transforming growth factor beta (TGF beta): a key role in liver fibrogenesis. J Hepatol. 22:1995;37-42.
26. Czaja MJ, Weiner FR, Flanders KC, Giambrone MA, Wind R, Biempica L, et al. In vitro and in vivo association of transforming growth factor-β1 with hepatic fibrosis. J Cell Biol. 108:1989;2477-2482.
27. Edwards DR, Murphy G, Reynolds JJ, Whitham SE, Docherty AJP, Angel P, et al. Transforming growth factor beta modulates the expression of collagenase and metallproteinase inhibitor. Embo J. 6:1987;1899-1904.
28. Friedman SL, Arthur MJ. Activation of cultured rat hepatic lipocytes by Kupffer cell conditioned medium: direct enhancement of matrix synthesis and stimulation of cell proliferation via induction of platelet-derived growth factor receptors. J Clin Invest. 84:1989;1780-1785.
29. Lalazar A, Wong L, Yamasaki G, Friedman SL. Early genes induced in hepatic stellate cells during wound healing. Gene. 195:1997;235-243.
30. Stowell RE, Lee CS, Tsuboi KK, Villasana A. Histochemical and microchemical changes in experimental cirrhosis and hepatoma formation in mice by carbon tetrachloride. Cancer Res. 53:1950;345-354.
31. Shi Z, Wakil AE, Rockey DC. Strain-specific differences in mouse hepatic wound healing are mediated by divergent T helper cytokine responses. Cell Biol. 94:1997;10663-10668.
32. Kulkarni AB, Huh CG, Becker D, Geiser A, Lyght M, Flanders KC, et al. Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. Proc Natl Acad Sci USA. 90:1993;770-774.
33. Geiser AG, Letterio JJ, Kulkarni AB, Karlsson S, Roberts AB, Sporn MB. Transforming growth factor beta 1 controls expression of major histocompatibility genes in the postnatal mouse: aberrant histocompatibility antigen expression in the pathogenesis of the TGF-beta 1 null mouse phenotype. Proc Natl Acad Sci USA. 90:1993;9944-9948.
34. Brenner DA, Veloz L, Jaenisch R, Alcorn JM. Stimulation of the collagen α1(I) endogenous gene and transgene in carbon tetrachloride-induced hepatic fibrosis. Hepatology. 17:1993;287-292.
35. Villarreal FJ, Lee AA, Dillmann WH, Giordano FJ. Adenovirus-mediated overexpression of human transforming growth factorbeta 1 in rat cardiac fibroblasts, myocytes and smooth muscle cells. J Mol Cell Cardiol. 28:1996;735-742.
36. Iimuro Y, Nishiura T, Hellerbrand C, Behrns K, Schoonhoven R, Grisham JW, et al. NFkB prevents apoptosis and liver failure during liver regeneration. J Clin Invest. 101:1997;802-811.
37. Rippe RA, Almounajed G, Brenner DA. Spl binding activity increases in activated Ito cells. Hepatology. 22:1995;241-251.
38. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal Biochem. 162:1987;156-159.
39. Rhodes K, Hall K, Lee KE, Razzaghi H, Breindl M. Correct cell- and differentiation-specific expression of a murine alpha 1 (I) collagen minigene in vitro differentiating embryonal carcinoma cells. Gene Express. 6:1996;35-44.
40. Stefanovic B, Hellerbrand C, Holcik M, Briendl M, Liebhaber SA, Brenner DA. Posttranscriptional regulation of collagen alpha 1(I) mRNA in hepatic stellate cells. Mol Cell Biol. 17:1997;5201-5209.
41. Madlener FS, Werner S. Transforming growth factors betal, beta2, beta3 and their receptors are differentially regulated during normal and impaired wound healing. J Biol Chem. 27:1996;10188-10193.
42. Hellerbrand C, Wang SC, Tsukamoto H, Brenner DA, Rippe RA. Expression of intercellular adhesion molecule 1 by activated hepatic stellate cells. Hepatology. 24:1996;670-676.
43. Mitchen J, Bletzinger D, Rago R, Wilding G. Use of a DNA microfluorometric assay to measure proliferative response of mink lung cells to purified TGF beta and to TGF beta activity found in prostate cell conditioned medium. In Vitro Cell Devel Biol Anim. 31:1995;692-697.
44. Lawrence DA. Identification and activation of latent transforming growth factor Beta. Methods Enzymol. 198:1991;327-336.
45. Britton RS, Bacon BR. Role of free radicals in liver diseases and hepatic fibrosis. Hepatogastroenterology. 41:1994;343-348.
46. Lee KS, Buck M, Houglum K, Chojkier M. Activation of hepatic stellate cells by TGFα and collagen type I is mediated by oxidative stress through c-myb expression. J Clin Invest. 96:1995;2461-2468.
47. Halim AB, el-Ahmady O, Hassab-Allan S, Abdel-Galil F, Hafez Y, Darwish A. Biochemical effect of antioxidants on lipids and liver function in experimentally-induced liver damage. Ann Clin Biochem. 34:1997;656-663.
48. 4-induced liver cirrhosis. Life Sci. 54:1994;2071-2082.
49. Morrow JD, Minton TA, Mukundan CR, Campbell MD, Zackert WE, Daniel VC, et al. Free radical-induced generation of isoprostanes in vivo. Evidence for the formation of D-ring and E-ring isoprostanes. J Biol Chem. 269:1994;4317-4326.
50. Liu P, Kawada N, Mizoguchi Y, Morisawa S. Arachidonate metabolism in D-galactosamine or carbon tetrachloride-induced acute and chronic liver injuries in rats. Gastoenterology Japan. 27:1992;624-631.
51. Morrow JD, Awad JA, Kato T, Takahashi K, Badr KF, Roberts LJJ, et al. Formation of novel non-cyclooxygenase-derived prostanoids (F2-isoprostanes) in carbon tetrachloride hepatotoxicity. An animal model of lipid peroxidation. J Clin Invest. 90:1992;2502-2507.
52. Kawada N, Mizoguchi Y, Kobayashi K, Yamamoto S, Morisawa S. Arachidonic acid metabolites in carbon tetrachloride-induced liver injury. Gastoenterology Japan. 25:1990;363-368.
53. Seong-Jin Kim, Jeang K-T, Glick AB, Sporn MB, Roberts AB. Promoter sequences of the human transforming growth factor betal gene responsive to transforming growth factor betal autoinduction. J Biol Chem. 264:1989;7041-7045.
54. O'Reilly MA, Danielpour D, Roberts AB, Sporn MB. Regulation of expression of transforming growth factor-beta 2 by transforming growth factor-beta isoforms is dependent upon cell type. Gut. 6:1992;193-201.
55. O'Reilly MA, Geiser AG, Kim SJ, Bruggeman LA, Luu AX, Roberts AB, et al. Identification of an activating transcription factor (ATF) binding site in the human transforming growth factorbeta 2 promoter. J Biol Chem. 267:1992;19938-19943.
56. Nugent P, Greene RM. Interactions between the transforming growth factor beta (TGF beta) and reinoic acid signal transduction pathways in murine embryonic palatal cells. Differentiation. 58:1994;149-155.
57. Sime PJ, Xing Z, Graham FL, Csaky KG, Gauldie J. Adenovector-mediated gene transfer of active transforming growth factorbetal induces prolonged severe fibrosis in rat lung. J Clin Invest. 100:1997;768-776.
58. Li Q, Kay MA, Finegold M, Stratford-Perricaudet LD, Woo SLC. Assessment of recombinant adenoviral vectors for hepatic gene therapy. Hum Gene Ther. 4:1993;403-409.
59. Drazan KE, Shen XD, Csete ME, Zhang WW, Roth JA, Busuttil RW, et al. In vivo adenoviral-mediated human p53 tumor suppressor gene transfer and expression in rat liver after resection. Surgery. 116:1994;197-203.
60. Chang AGY, Wu GY. Gene therapy: applications to the treatment of gastrointestinal and liver diseases. Gastroenterology. 106:1994;1076-1084.
61. Kozarsky KF, McKinley DR, Austin LL, Raper SE, Stratford-Perricaudet LD, Wilson JM. In vivo correction of low density lipoprotein receptor deficiency in the Watanabe heritable hyperli-pidemic rabbit with recombinant adenoviruses. J Biol Chem. 269:1994;13695-13702.
62. Kay MA, Landen CN, Rothenberg SR, Taylor LA, Leland F, Wiehle S, et al. In vivo hepatic gene therapy: complete albeit transient correction of factor IX deficiency in hemophilia B dogs. Proc Natl Acad Sci USA. 91:1994;2353-2357.
63. Engelhardt JF, Ye X, Doranz B, Wilson JM. Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver. Proc Natl Acad Sci USA. 91:1994;6196-6200.
64. Gao GP, Yang Y, Wilson YM. Biology of adenovirus vectors with E1 and E4 deletions for liver-directed gene therapy. J Virol. 70:1996;8934-8943.
65. Drazan KE, Csete ME, Da Shen X, Bullington D, Cottle G, Busuttil RW, et al. Hepatic function is preserved following liverdirected, adenovirus-mediated gene transfer. J Surg Res. 59:1995;299-304.
66. Drazan KJE, Wu L, Olthoff KM, Jurim O, Busuttil RW, Shaked A. Transduction of hepatic allografts achieves local levels of viral IL-10 which suppress alloreactivity in vitro. J Surg Res. 59:1995;219-223.
67. Davis BH, Kramer RT, Davidson NO. Retinoic acid modulates rat Ito cell proliferation, collagen, and transforming growth factor-β production. J Clin Invest. 86:1990;2062-2070.
68. Saile B, Knittel T, Matthes N, Schott P, Ramadori G. CD95/CD95L-mediated apoptosis of the hepatic stellate cell. Am J Physiol. 151:1997;1265-1272.