-
1
-
-
80052468996
-
Mechanisms balancing tolerance and immunity in the liver
-
Bottcher, J. P., Knolle, P. A. & Stabenow, D. Mechanisms balancing tolerance and immunity in the liver. Dig. Dis. 29, 384-390 (2011).
-
(2011)
Dig. Dis.
, vol.29
, pp. 384-390
-
-
Bottcher, J.P.1
Knolle, P.A.2
Stabenow, D.3
-
2
-
-
33644544110
-
The liver as an immunological organ
-
Racanelli, V. & Rehermann, B. The liver as an immunological organ. Hepatology 43, S54-S62 (2006).
-
(2006)
Hepatology
, vol.43
, pp. S54-S62
-
-
Racanelli, V.1
Rehermann, B.2
-
3
-
-
67349182474
-
Operational tolerance after liver transplantation
-
Orlando, G., Soker, S. & Wood, K. Operational tolerance after liver transplantation. J. Hepatol. 50, 1247-1257 (2009).
-
(2009)
J. Hepatol.
, vol.50
, pp. 1247-1257
-
-
Orlando, G.1
Soker, S.2
Wood, K.3
-
4
-
-
84898936752
-
Hepatic immune regulation and its involvement in viral hepatitis infection
-
Knolle, P. A. & Thimme, R. Hepatic immune regulation and its involvement in viral hepatitis infection. Gastroenterology 146, 1193-1207 (2014).
-
(2014)
Gastroenterology
, vol.146
, pp. 1193-1207
-
-
Knolle, P.A.1
Thimme, R.2
-
5
-
-
67650750880
-
The liver as a lymphoid organ
-
Crispe, I. N. The liver as a lymphoid organ. Annu. Rev. Immunol. 27, 147-163 (2009).
-
(2009)
Annu. Rev. Immunol.
, vol.27
, pp. 147-163
-
-
Crispe, I.N.1
-
6
-
-
0033779915
-
Endotoxin and cytokine regulation of toll-like receptor (TLR) 2 and TLR4 gene expression in murine liver and hepatocytes
-
Matsumura, T., Ito, A., Takii, T., Hayashi, H. & Onozaki, K. Endotoxin and cytokine regulation of toll-like receptor (TLR) 2 and TLR4 gene expression in murine liver and hepatocytes. J. Interferon Cytokine Res. 20, 915-921 (2000).
-
(2000)
J. Interferon Cytokine Res.
, vol.20
, pp. 915-921
-
-
Matsumura, T.1
Ito, A.2
Takii, T.3
Hayashi, H.4
Onozaki, K.5
-
7
-
-
35948958955
-
TLR4 enhances TGF-β signaling and hepatic fibrosis
-
Seki, E. et al. TLR4 enhances TGF-β signaling and hepatic fibrosis. Nat. Med. 13, 1324-1332 (2007).
-
(2007)
Nat. Med.
, vol.13
, pp. 1324-1332
-
-
Seki, E.1
-
8
-
-
77958557979
-
Antigen-presenting cell function in the tolerogenic liver environment
-
Thomson, A. W. & Knolle, P. A. Antigen-presenting cell function in the tolerogenic liver environment. Nat. Rev. Immunol. 10, 753-766 (2010).
-
(2010)
Nat. Rev. Immunol.
, vol.10
, pp. 753-766
-
-
Thomson, A.W.1
Knolle, P.A.2
-
9
-
-
84899960512
-
Pathology of the liver sinusoids
-
Brunt, E. M. et al. Pathology of the liver sinusoids. Histopathology 64, 907-920 (2014).
-
(2014)
Histopathology
, vol.64
, pp. 907-920
-
-
Brunt, E.M.1
-
10
-
-
84870877532
-
Functional role of monocytes and macrophages for the inflammatory response in acute liver injury
-
Zimmermann, H. W., Trautwein, C. & Tacke, F. Functional role of monocytes and macrophages for the inflammatory response in acute liver injury. Front. Physiol. 3, 56 (2012).
-
(2012)
Front. Physiol.
, vol.3
, pp. 56
-
-
Zimmermann, H.W.1
Trautwein, C.2
Tacke, F.3
-
11
-
-
84926659037
-
The complex myeloid network of the liver with diverse functional capacity at steady state and in inflammation
-
Eckert, C., Klein, N., Kornek, M. & Lukacs-Kornek, V. The complex myeloid network of the liver with diverse functional capacity at steady state and in inflammation. Front. Immunol. 6, 179 (2015).
-
(2015)
Front. Immunol.
, vol.6
, pp. 179
-
-
Eckert, C.1
Klein, N.2
Kornek, M.3
Lukacs-Kornek, V.4
-
12
-
-
70149090633
-
Liver natural killer and natural killer T cells: Immunobiology and emerging roles in liver diseases
-
Gao, B., Radaeva, S. & Park, O. Liver natural killer and natural killer T cells: immunobiology and emerging roles in liver diseases. J. Leukoc. Biol. 86, 513-528 (2009).
-
(2009)
J. Leukoc. Biol.
, vol.86
, pp. 513-528
-
-
Gao, B.1
Radaeva, S.2
Park, O.3
-
13
-
-
84898789996
-
Macrophage heterogeneity in liver injury and fibrosis
-
Tacke, F. & Zimmermann, H. W. Macrophage heterogeneity in liver injury and fibrosis. J. Hepatol. 60, 1090-1096 (2014).
-
(2014)
J. Hepatol.
, vol.60
, pp. 1090-1096
-
-
Tacke, F.1
Zimmermann, H.W.2
-
14
-
-
58149388026
-
Origins and tissue-context-dependent fates of blood monocytes
-
Varol, C., Yona, S. & Jung, S. Origins and tissue-context-dependent fates of blood monocytes. Immunol. Cell Biol. 87, 30-38 (2009).
-
(2009)
Immunol. Cell Biol.
, vol.87
, pp. 30-38
-
-
Varol, C.1
Yona, S.2
Jung, S.3
-
15
-
-
84925465211
-
Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors
-
Gomez Perdiguero, E. et al. Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors. Nature 518, 547-551 (2015).
-
(2015)
Nature
, vol.518
, pp. 547-551
-
-
Gomez Perdiguero, E.1
-
16
-
-
84872765982
-
Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis
-
Yona, S. et al. Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis. Immunity 38, 79-91 (2013).
-
(2013)
Immunity
, vol.38
, pp. 79-91
-
-
Yona, S.1
-
17
-
-
84859508307
-
A lineage of myeloid cells independent of Myb and hematopoietic stem cells
-
Schulz, C. et al. A lineage of myeloid cells independent of Myb and hematopoietic stem cells. Science 336, 86-90 (2012).
-
(2012)
Science
, vol.336
, pp. 86-90
-
-
Schulz, C.1
-
18
-
-
84864351457
-
Source and characterization of hepatic macrophages in acetaminophen-induced acute liver failure in humans
-
Antoniades, C. G. et al. Source and characterization of hepatic macrophages in acetaminophen-induced acute liver failure in humans. Hepatology 56, 735-746 (2012).
-
(2012)
Hepatology
, vol.56
, pp. 735-746
-
-
Antoniades, C.G.1
-
19
-
-
84865418665
-
Deciphering the transcriptional network of the dendritic cell lineage
-
Miller, J. C. et al. Deciphering the transcriptional network of the dendritic cell lineage. Nat. Immunol. 13, 888-899 (2012).
-
(2012)
Nat. Immunol.
, vol.13
, pp. 888-899
-
-
Miller, J.C.1
-
21
-
-
61449193205
-
Human liver dendritic cells promote T cell hyporesponsiveness
-
Bamboat, Z. M. et al. Human liver dendritic cells promote T cell hyporesponsiveness. J. Immunol. 182, 1901-1911 (2009).
-
(2009)
J. Immunol.
, vol.182
, pp. 1901-1911
-
-
Bamboat, Z.M.1
-
22
-
-
84933177312
-
Liver inflammation abrogates immunological tolerance induced by Kupffer cells
-
Heymann, F. et al. Liver inflammation abrogates immunological tolerance induced by Kupffer cells. Hepatology 62, 279-291 (2015).
-
(2015)
Hepatology
, vol.62
, pp. 279-291
-
-
Heymann, F.1
-
23
-
-
33644775720
-
CRIg: A macrophage complement receptor required for phagocytosis of circulating pathogens
-
Helmy, K. Y. et al. CRIg: a macrophage complement receptor required for phagocytosis of circulating pathogens. Cell 124, 915-927 (2006).
-
(2006)
Cell
, vol.124
, pp. 915-927
-
-
Helmy, K.Y.1
-
24
-
-
0028917669
-
Human Kupffer cells secrete IL-10 in response to lipopolysaccharide (LPS) challenge
-
Knolle, P. et al. Human Kupffer cells secrete IL-10 in response to lipopolysaccharide (LPS) challenge. J. Hepatol. 22, 226-229 (1995).
-
(1995)
J. Hepatol.
, vol.22
, pp. 226-229
-
-
Knolle, P.1
-
25
-
-
84886646838
-
Immune surveillance by the liver
-
Jenne, C. N. & Kubes, P. Immune surveillance by the liver. Nat. Immunol. 14, 996-1006 (2013).
-
(2013)
Nat. Immunol.
, vol.14
, pp. 996-1006
-
-
Jenne, C.N.1
Kubes, P.2
-
26
-
-
33745616804
-
low/neg accessory cells with dendritic-cell features
-
low/neg accessory cells with dendritic-cell features. Blood 108, 218-227 (2006).
-
(2006)
Blood
, vol.108
, pp. 218-227
-
-
Rutella, S.1
-
27
-
-
17044383038
-
absent dendritic cells with tolerogenic potential
-
absent dendritic cells with tolerogenic potential. J. Immunol. 174, 4706-4717 (2005).
-
(2005)
J. Immunol.
, vol.174
, pp. 4706-4717
-
-
Li, G.1
Kim, Y.J.2
Broxmeyer, H.E.3
-
28
-
-
18944377211
-
Flt3 ligand treatment reverses endotoxin tolerance-related immunoparalysis
-
Wysocka, M., Montaner, L. J. & Karp, C. L. Flt3 ligand treatment reverses endotoxin tolerance-related immunoparalysis. J. Immunol. 174, 7398-7402 (2005).
-
(2005)
J. Immunol.
, vol.174
, pp. 7398-7402
-
-
Wysocka, M.1
Montaner, L.J.2
Karp, C.L.3
-
29
-
-
84930018853
-
Combination of granulocyte colony-stimulating factor and erythropoietin improves outcomes of patients with decompensated cirrhosis
-
Kedarisetty, C. K. et al. Combination of granulocyte colony-stimulating factor and erythropoietin improves outcomes of patients with decompensated cirrhosis. Gastroenterology 148, 1362-1370.e7 (2015).
-
(2015)
Gastroenterology
, vol.148
, pp. 1362-1362e7
-
-
Kedarisetty, C.K.1
-
30
-
-
0037136328
-
Tryptophan-derived catabolites are responsible for inhibition of T and natural killer cell proliferation induced by indoleamine 2, 3-dioxygenase
-
Frumento, G. et al. Tryptophan-derived catabolites are responsible for inhibition of T and natural killer cell proliferation induced by indoleamine 2, 3-dioxygenase. J. Exp. Med. 196, 459-468 (2002).
-
(2002)
J. Exp. Med.
, vol.196
, pp. 459-468
-
-
Frumento, G.1
-
31
-
-
70350433798
-
Interferon-γ-triggered indoleamine 2, 3-dioxygenase competence in human monocyte-derived dendritic cells induces regulatory activity in allogeneic T cells
-
Jurgens, B., Hainz, U., Fuchs, D., Felzmann, T. & Heitger, A. Interferon-γ-triggered indoleamine 2, 3-dioxygenase competence in human monocyte-derived dendritic cells induces regulatory activity in allogeneic T cells. Blood 114, 3235-3243 (2009).
-
(2009)
Blood
, vol.114
, pp. 3235-3243
-
-
Jurgens, B.1
Hainz, U.2
Fuchs, D.3
Felzmann, T.4
Heitger, A.5
-
32
-
-
5644280249
-
The composition of intrahepatic lymphocytes: Shaped by selective recruitment?
-
Klugewitz, K., Adams, D. H., Emoto, M., Eulenburg, K. & Hamann, A. The composition of intrahepatic lymphocytes: shaped by selective recruitment? Trends Immunol. 25, 590-594 (2004).
-
(2004)
Trends Immunol.
, vol.25
, pp. 590-594
-
-
Klugewitz, K.1
Adams, D.H.2
Emoto, M.3
Eulenburg, K.4
Hamann, A.5
-
33
-
-
84878938696
-
Frequency and phenotype of human circulating and intrahepatic natural killer cell subsets is differentially regulated according to stage of chronic liver disease
-
Zimmermann, H. W. et al. Frequency and phenotype of human circulating and intrahepatic natural killer cell subsets is differentially regulated according to stage of chronic liver disease. Digestion 88, 1-16 (2013).
-
(2013)
Digestion
, vol.88
, pp. 1-16
-
-
Zimmermann, H.W.1
-
34
-
-
38749146900
-
TLR-dependent cross talk between human Kupffer cells and NK cells
-
Tu, Z. et al. TLR-dependent cross talk between human Kupffer cells and NK cells. J. Exp. Med. 205, 233-244 (2008).
-
(2008)
J. Exp. Med.
, vol.205
, pp. 233-244
-
-
Tu, Z.1
-
35
-
-
84928825044
-
Re-examining the origin and function of liver-resident NK cells
-
Peng, H. & Tian, Z. Re-examining the origin and function of liver-resident NK cells. Trends Immunol. 36, 293-299 (2015).
-
(2015)
Trends Immunol.
, vol.36
, pp. 293-299
-
-
Peng, H.1
Tian, Z.2
-
36
-
-
84899448933
-
A committed precursor to innate lymphoid cells
-
Constantinides, M. G., McDonald, B. D., Verhoef, P. A. & Bendelac, A. A committed precursor to innate lymphoid cells. Nature 508, 397-401 (2014).
-
(2014)
Nature
, vol.508
, pp. 397-401
-
-
Constantinides, M.G.1
McDonald, B.D.2
Verhoef, P.A.3
Bendelac, A.4
-
37
-
-
84924529960
-
+ NK cells
-
+ NK cells. J. Immunol. 194, 2467-2471 (2015).
-
(2015)
J. Immunol.
, vol.194
, pp. 2467-2471
-
-
Marquardt, N.1
-
38
-
-
19344371631
-
+ NKT cells patrolling liver sinusoids
-
+ NKT cells patrolling liver sinusoids. PLoS Biol. 3, e113 (2005).
-
(2005)
PLoS Biol.
, vol.3
, pp. e113
-
-
Geissmann, F.1
-
39
-
-
84877794003
-
Chemokine receptor CXCR6-dependent hepatic NK T Cell accumulation promotes inflammation and liver fibrosis
-
Wehr, A. et al. Chemokine receptor CXCR6-dependent hepatic NK T Cell accumulation promotes inflammation and liver fibrosis. J. Immunol. 190, 5226-5236 (2013).
-
(2013)
J. Immunol.
, vol.190
, pp. 5226-5236
-
-
Wehr, A.1
-
40
-
-
0035422520
-
Activating immunity in the liver. I. Liver dendritic cells (but not hepatocytes) are potent activators of IFN-γ release by liver NKT cells
-
Trobonjaca, Z., Leithäuser, F., Möller, P., Schirmbeck, R. & Reimann, J. Activating immunity in the liver. I. Liver dendritic cells (but not hepatocytes) are potent activators of IFN-γ release by liver NKT cells. J. Immunol. 167, 1413-1422 (2001).
-
(2001)
J. Immunol.
, vol.167
, pp. 1413-1422
-
-
Trobonjaca, Z.1
Leithäuser, F.2
Möller, P.3
Schirmbeck, R.4
Reimann, J.5
-
41
-
-
12844285609
-
Glycolipid presentation to natural killer T cells differs in an organ-dependent fashion
-
Schmieg, J., Yang, G., Franck, R. W., Van Rooijen, N. & Tsuji, M. Glycolipid presentation to natural killer T cells differs in an organ-dependent fashion. Proc. Natl Acad. Sci. USA 102, 1127-1132 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 1127-1132
-
-
Schmieg, J.1
Yang, G.2
Franck, R.W.3
Van Rooijen, N.4
Tsuji, M.5
-
42
-
-
0042123683
-
NKT cells from normal and tumor-bearing human livers are phenotypically and functionally distinct from murine NKT cells
-
Kenna, T. et al. NKT cells from normal and tumor-bearing human livers are phenotypically and functionally distinct from murine NKT cells. J. Immunol. 171, 1775-1779 (2003).
-
(2003)
J. Immunol.
, vol.171
, pp. 1775-1779
-
-
Kenna, T.1
-
43
-
-
77954914800
-
Antimicrobial activity of mucosal-associated invariant T cells
-
Le Bourhis, L. et al. Antimicrobial activity of mucosal-associated invariant T cells. Nat. Immunol. 11, 701-708 (2010).
-
(2010)
Nat. Immunol.
, vol.11
, pp. 701-708
-
-
Le Bourhis, L.1
-
44
-
-
84875466830
-
IL-7 licenses activation of human liver intrasinusoidal mucosal-associated invariant T cells
-
Tang, X.-Z. et al. IL-7 licenses activation of human liver intrasinusoidal mucosal-associated invariant T cells. J. Immunol. 190, 3142-3152 (2013).
-
(2013)
J. Immunol.
, vol.190
, pp. 3142-3152
-
-
Tang, X.-Z.1
-
45
-
-
66149152203
-
Systemic antigen cross-presented by liver sinusoidal endothelial cells induces liver-specific CD8 T-cell retention and tolerization
-
von Oppen, N. et al. Systemic antigen cross-presented by liver sinusoidal endothelial cells induces liver-specific CD8 T-cell retention and tolerization. Hepatology 49, 1664-1672 (2009).
-
(2009)
Hepatology
, vol.49
, pp. 1664-1672
-
-
Von Oppen, N.1
-
46
-
-
84878937578
-
The regulation of T-cell recruitment to the human liver during acute liver failure
-
Tuncer, C., Oo, Y. H., Murphy, N., Adams, D. H. & Lalor, P. F. The regulation of T-cell recruitment to the human liver during acute liver failure. Liver Int. 33, 852-863 (2013).
-
(2013)
Liver Int.
, vol.33
, pp. 852-863
-
-
Tuncer, C.1
Oo, Y.H.2
Murphy, N.3
Adams, D.H.4
Lalor, P.F.5
-
47
-
-
0037270978
-
Hepatic T cells and liver tolerance
-
Crispe, I. N. Hepatic T cells and liver tolerance. Nat. Rev. Immunol. 3, 51-62 (2003).
-
(2003)
Nat. Rev. Immunol.
, vol.3
, pp. 51-62
-
-
Crispe, I.N.1
-
48
-
-
79959555074
-
Murine hepatic stellate cells veto CD8 T cell activation by a CD54-dependent mechanism
-
Schildberg, F. A. et al. Murine hepatic stellate cells veto CD8 T cell activation by a CD54-dependent mechanism. Hepatology 54, 262-272 (2011).
-
(2011)
Hepatology
, vol.54
, pp. 262-272
-
-
Schildberg, F.A.1
-
49
-
-
33846212347
-
Ito cells are liver-resident antigen-presenting cells for activating T cell responses
-
Winau, F. et al. Ito cells are liver-resident antigen-presenting cells for activating T cell responses. Immunity 26, 117-129 (2007).
-
(2007)
Immunity
, vol.26
, pp. 117-129
-
-
Winau, F.1
-
50
-
-
84924230659
-
Cellular and molecular functions of hepatic stellate cells in inflammatory responses and liver immunology
-
Weiskirchen, R. & Tacke, F. Cellular and molecular functions of hepatic stellate cells in inflammatory responses and liver immunology. Hepatobiliary Surg. Nutr. 3, 344-363 (2014).
-
(2014)
Hepatobiliary Surg. Nutr.
, vol.3
, pp. 344-363
-
-
Weiskirchen, R.1
Tacke, F.2
-
51
-
-
84879844767
-
Human hepatic stellate cells inhibit T-cell response through B7-H1 pathway
-
Charles, R. et al. Human hepatic stellate cells inhibit T-cell response through B7-H1 pathway. Transplantation 96, 17-24 (2013).
-
(2013)
Transplantation
, vol.96
, pp. 17-24
-
-
Charles, R.1
-
52
-
-
51349131121
-
Mechanism of T cell tolerance induction by murine hepatic Kupffer cells
-
You, Q., Cheng, L., Kedl, R. M. & Ju, C. Mechanism of T cell tolerance induction by murine hepatic Kupffer cells. Hepatology 48, 978 (2008).
-
(2008)
Hepatology
, vol.48
, pp. 978
-
-
You, Q.1
Cheng, L.2
Kedl, R.M.3
Ju, C.4
-
53
-
-
76549127740
-
Inhibition of allogeneic T-cell response by Kupffer cells expressing indoleamine 2, 3-dioxygenase
-
Yan, M. L., Wang, Y. D., Tian, Y. F., Lai, Z. D. & Yan, L. N. Inhibition of allogeneic T-cell response by Kupffer cells expressing indoleamine 2, 3-dioxygenase. World J. Gastroenterol. 16, 636-640 (2010).
-
(2010)
World J. Gastroenterol.
, vol.16
, pp. 636-640
-
-
Yan, M.L.1
Wang, Y.D.2
Tian, Y.F.3
Lai, Z.D.4
Yan, L.N.5
-
54
-
-
0033002962
-
+ T cells by antigen-presenting murine liver sinusoidal endothelial cells but failure to induce differentiation toward Th1 cells
-
+ T cells by antigen-presenting murine liver sinusoidal endothelial cells but failure to induce differentiation toward Th1 cells. Gastroenterology 116, 1428-1440 (1999).
-
(1999)
Gastroenterology
, vol.116
, pp. 1428-1440
-
-
Knolle, P.A.1
-
55
-
-
84871247127
-
Inhibition of inflammatory CD4 T cell activity by murine liver sinusoidal endothelial cells
-
Carambia, A. et al. Inhibition of inflammatory CD4 T cell activity by murine liver sinusoidal endothelial cells. J. Hepatol. 58, 112-118 (2013).
-
(2013)
J. Hepatol.
, vol.58
, pp. 112-118
-
-
Carambia, A.1
-
56
-
-
73149098744
-
- regulatory T cells suppressing autoimmune hepatitis
-
- regulatory T cells suppressing autoimmune hepatitis. Hepatology 50, 1904-1913 (2009).
-
(2009)
Hepatology
, vol.50
, pp. 1904-1913
-
-
Kruse, N.1
-
57
-
-
84874268340
-
+ regulatory T cells by production of retinoic acid
-
+ regulatory T cells by production of retinoic acid. J. Immunol. 190, 2009-2016 (2013).
-
(2013)
J. Immunol.
, vol.190
, pp. 2009-2016
-
-
Dunham, R.M.1
-
58
-
-
72549114816
-
PD-1/B7-H1 interaction contribute to the spontaneous acceptance of mouse liver allograft
-
Morita, M. et al. PD-1/B7-H1 interaction contribute to the spontaneous acceptance of mouse liver allograft. Am. J. Transplant. 10, 40-46 (2010).
-
(2010)
Am. J. Transplant.
, vol.10
, pp. 40-46
-
-
Morita, M.1
-
59
-
-
0034533209
-
+ T cells results in antigen-specific T-cell tolerance
-
+ T cells results in antigen-specific T-cell tolerance. Nat. Med. 6, 1348-1354 (2000).
-
(2000)
Nat. Med.
, vol.6
, pp. 1348-1354
-
-
Limmer, A.1
-
60
-
-
27644481817
-
Cross-presentation of oral antigens by liver sinusoidal endothelial cells leads to CD8 T cell tolerance
-
Limmer, A. et al. Cross-presentation of oral antigens by liver sinusoidal endothelial cells leads to CD8 T cell tolerance. Eur. J. Immunol. 35, 2970-2981 (2005).
-
(2005)
Eur. J. Immunol.
, vol.35
, pp. 2970-2981
-
-
Limmer, A.1
-
61
-
-
38649137987
-
+ T cell tolerance
-
+ T cell tolerance. Hepatology 47, 296-305 (2008).
-
(2008)
Hepatology
, vol.47
, pp. 296-305
-
-
Diehl, L.1
-
62
-
-
51449107778
-
Intrahepatic murine CD8 T-cell activation associates with a distinct phenotype leading to Bim-dependent death
-
Holz, L. E. et al. Intrahepatic murine CD8 T-cell activation associates with a distinct phenotype leading to Bim-dependent death. Gastroenterology 135, 989-997 (2008).
-
(2008)
Gastroenterology
, vol.135
, pp. 989-997
-
-
Holz, L.E.1
-
63
-
-
43049112084
-
Bim-mediated deletion of antigen-specific CD8 T cells in patients unable to control HBV infection
-
Lopes, A. R. et al. Bim-mediated deletion of antigen-specific CD8 T cells in patients unable to control HBV infection. J. Clin. Invest. 118, 1835-1845 (2008).
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 1835-1845
-
-
Lopes, A.R.1
-
64
-
-
80053653657
-
Hepatocyte entry leads to degradation of autoreactive CD8 T cells
-
Benseler, V. et al. Hepatocyte entry leads to degradation of autoreactive CD8 T cells. Proc. Natl Acad. Sci. USA 108, 16735-16740 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 16735-16740
-
-
Benseler, V.1
-
65
-
-
84864748513
-
Alarmins: Awaiting a clinical response
-
Chan, J. K. et al. Alarmins: awaiting a clinical response. J. Clin. Invest. 122, 2711-2719 (2012).
-
(2012)
J. Clin. Invest.
, vol.122
, pp. 2711-2719
-
-
Chan, J.K.1
-
66
-
-
84865169674
-
IL-33 and HMGB1 alarmins: Sensors of cellular death and their involvement in liver pathology
-
Arshad, M. I., Piquet-Pellorce, C. & Samson, M. IL-33 and HMGB1 alarmins: sensors of cellular death and their involvement in liver pathology. Liver Int. 32, 1200-1210 (2012).
-
(2012)
Liver Int.
, vol.32
, pp. 1200-1210
-
-
Arshad, M.I.1
Piquet-Pellorce, C.2
Samson, M.3
-
67
-
-
84891735940
-
Bile acid receptors as targets for drug development
-
Schaap, F. G., Trauner, M. & Jansen, P. L. Bile acid receptors as targets for drug development. Nat. Rev. Gastroenterol. Hepatol. 11, 55-67 (2014).
-
(2014)
Nat. Rev. Gastroenterol. Hepatol.
, vol.11
, pp. 55-67
-
-
Schaap, F.G.1
Trauner, M.2
Jansen, P.L.3
-
68
-
-
78650793157
-
Bile acids induce inflammatory genes in hepatocytes: A novel mechanism of inflammation during obstructive cholestasis
-
Allen, K., Jaeschke, H. & Copple, B. L. Bile acids induce inflammatory genes in hepatocytes: a novel mechanism of inflammation during obstructive cholestasis. Am. J. Pathol. 178, 175-186 (2011).
-
(2011)
Am. J. Pathol.
, vol.178
, pp. 175-186
-
-
Allen, K.1
Jaeschke, H.2
Copple, B.L.3
-
69
-
-
84871330823
-
The cholesterol derivative 27-hydroxycholesterol reduces steatohepatitis in mice
-
Bieghs, V. et al. The cholesterol derivative 27-hydroxycholesterol reduces steatohepatitis in mice. Gastroenterology 144, 167-178.e1 (2013).
-
(2013)
Gastroenterology
, vol.144
, pp. 167-167e1
-
-
Bieghs, V.1
-
70
-
-
83755163159
-
A high-cholesterol diet exacerbates liver fibrosis in mice via accumulation of free cholesterol in hepatic stellate cells
-
Teratani, T. et al. A high-cholesterol diet exacerbates liver fibrosis in mice via accumulation of free cholesterol in hepatic stellate cells. Gastroenterology 142, 152-164.e10 (2012).
-
(2012)
Gastroenterology
, vol.142
, pp. 152-152e10
-
-
Teratani, T.1
-
71
-
-
34247236200
-
Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE
-
Tian, J. et al. Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE. Nat. Immunol. 8, 487-496 (2007).
-
(2007)
Nat. Immunol.
, vol.8
, pp. 487-496
-
-
Tian, J.1
-
72
-
-
84948614431
-
The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis
-
Huebener, P. et al. The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis. J. Clin. Invest. 125, 539-550 (2015).
-
(2015)
J. Clin. Invest.
, vol.125
, pp. 539-550
-
-
Huebener, P.1
-
73
-
-
20244373939
-
The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion
-
Tsung, A. et al. The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion. J. Exp. Med. 201, 1135-1143 (2005).
-
(2005)
J. Exp. Med.
, vol.201
, pp. 1135-1143
-
-
Tsung, A.1
-
74
-
-
84901013877
-
Structural biology of the IL-1 superfamily: Key cytokines in the regulation of immune and inflammatory responses
-
Krumm, B., Xiang, Y. & Deng, J. Structural biology of the IL-1 superfamily: key cytokines in the regulation of immune and inflammatory responses. Protein Sci. 23, 526-538 (2014).
-
(2014)
Protein Sci.
, vol.23
, pp. 526-538
-
-
Krumm, B.1
Xiang, Y.2
Deng, J.3
-
75
-
-
83555160892
-
Protective role of IL-33/ST2 axis in Con A-induced hepatitis
-
Volarevic, V. et al. Protective role of IL-33/ST2 axis in Con A-induced hepatitis. J. Hepatol. 56, 26-33 (2012).
-
(2012)
J. Hepatol.
, vol.56
, pp. 26-33
-
-
Volarevic, V.1
-
76
-
-
84882580383
-
Interleukin-33-dependent innate lymphoid cells mediate hepatic fibrosis
-
McHedlidze, T. et al. Interleukin-33-dependent innate lymphoid cells mediate hepatic fibrosis. Immunity 39, 357-371 (2013).
-
(2013)
Immunity
, vol.39
, pp. 357-371
-
-
McHedlidze, T.1
-
77
-
-
83555160887
-
IL-33 - A cytokine which balances on a knife's edge?
-
Erhardt, A. & Tiegs, G. IL-33 - A cytokine which balances on a knife's edge? J. Hepatol. 56, 7-10 (2012).
-
(2012)
J. Hepatol.
, vol.56
, pp. 7-10
-
-
Erhardt, A.1
Tiegs, G.2
-
78
-
-
84936891896
-
Inflammasomes: Mechanism of action, role in disease, and therapeutics
-
Guo, H., Callaway, J. B. & Ting, J. P. Inflammasomes: mechanism of action, role in disease, and therapeutics. Nat. Med. 21, 677-687 (2015).
-
(2015)
Nat. Med.
, vol.21
, pp. 677-687
-
-
Guo, H.1
Callaway, J.B.2
Ting, J.P.3
-
79
-
-
66749174867
-
The inflammasomes: Guardians of the body
-
Martinon, F., Mayor, A. & Tschopp, J. The inflammasomes: guardians of the body. Annu. Rev. Immunol. 27, 229-265 (2009).
-
(2009)
Annu. Rev. Immunol.
, vol.27
, pp. 229-265
-
-
Martinon, F.1
Mayor, A.2
Tschopp, J.3
-
80
-
-
84865504141
-
Sterile inflammation in the liver
-
Kubes, P. & Mehal, W. Z. Sterile inflammation in the liver. Gastroenterology 143, 1158-1172 (2012).
-
(2012)
Gastroenterology
, vol.143
, pp. 1158-1172
-
-
Kubes, P.1
Mehal, W.Z.2
-
81
-
-
0036671894
-
The inflammasome: A molecular platform triggering activation of inflammatory caspases and processing of proIL-β
-
Martinon, F., Burns, K. & Tschopp, J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-β. Mol. Cell 10, 417-426 (2002).
-
(2002)
Mol. Cell
, vol.10
, pp. 417-426
-
-
Martinon, F.1
Burns, K.2
Tschopp, J.3
-
82
-
-
79751512463
-
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
-
Vandanmagsar, B. et al. The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat. Med. 17, 179-188 (2011).
-
(2011)
Nat. Med.
, vol.17
, pp. 179-188
-
-
Vandanmagsar, B.1
-
83
-
-
84879605752
-
ASC/caspase-1/IL-1β signaling triggers inflammatory responses by promoting HMGB1 induction in liver ischemia/reperfusion injury
-
Kamo, N. et al. ASC/caspase-1/IL-1β signaling triggers inflammatory responses by promoting HMGB1 induction in liver ischemia/reperfusion injury. Hepatology 58, 351-362 (2013).
-
(2013)
Hepatology
, vol.58
, pp. 351-362
-
-
Kamo, N.1
-
84
-
-
84883367417
-
Histones activate the NLRP3 inflammasome in Kupffer cells during sterile inflammatory liver injury
-
Huang, H. et al. Histones activate the NLRP3 inflammasome in Kupffer cells during sterile inflammatory liver injury. J. Immunol. 191, 2665-2679 (2013).
-
(2013)
J. Immunol.
, vol.191
, pp. 2665-2679
-
-
Huang, H.1
-
85
-
-
77957943307
-
Intravascular danger signals guide neutrophils to sites of sterile inflammation
-
McDonald, B. et al. Intravascular danger signals guide neutrophils to sites of sterile inflammation. Science 330, 362-366 (2010).
-
(2010)
Science
, vol.330
, pp. 362-366
-
-
McDonald, B.1
-
86
-
-
84875642466
-
Altered responsiveness to extracellular ATP enhances acetaminophen hepatotoxicity
-
Amaral, S. S. et al. Altered responsiveness to extracellular ATP enhances acetaminophen hepatotoxicity. Cell Commun. Signal. 11, 10 (2013).
-
(2013)
Cell Commun. Signal.
, vol.11
, pp. 10
-
-
Amaral, S.S.1
-
87
-
-
84896709837
-
NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice
-
Wree, A. et al. NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice. Hepatology 59, 898-910 (2014).
-
(2014)
Hepatology
, vol.59
, pp. 898-910
-
-
Wree, A.1
-
88
-
-
84925516213
-
Extracellular ATP induces P2X7 receptor activation in mouse Kupffer cells, leading to release of IL-1β, HMGB1, and PGE2, decreased MHC class i expression and necrotic cell death
-
Toki, Y. et al. Extracellular ATP induces P2X7 receptor activation in mouse Kupffer cells, leading to release of IL-1β, HMGB1, and PGE2, decreased MHC class I expression and necrotic cell death. Biochem. Biophys. Res. Commun. 458, 771-776 (2015).
-
(2015)
Biochem. Biophys. Res. Commun.
, vol.458
, pp. 771-776
-
-
Toki, Y.1
-
89
-
-
84901218517
-
Lactate reduces liver and pancreatic injury in Toll-like receptor-and inflammasome-mediated inflammation via GPR81-mediated suppression of innate immunity
-
Hoque, R., Farooq, A., Ghani, A., Gorelick, F. & Mehal, W. Z. Lactate reduces liver and pancreatic injury in Toll-like receptor-and inflammasome-mediated inflammation via GPR81-mediated suppression of innate immunity. Gastroenterology 146, 1763-1774 (2014).
-
(2014)
Gastroenterology
, vol.146
, pp. 1763-1774
-
-
Hoque, R.1
Farooq, A.2
Ghani, A.3
Gorelick, F.4
Mehal, W.Z.5
-
90
-
-
84870986481
-
Toll-like receptors in liver disease
-
Petrasek, J., Csak, T. & Szabo, G. Toll-like receptors in liver disease. Adv. Clin. Chem. 59, 155-201 (2013).
-
(2013)
Adv. Clin. Chem.
, vol.59
, pp. 155-201
-
-
Petrasek, J.1
Csak, T.2
Szabo, G.3
-
91
-
-
84907225684
-
Alterations of the human gut microbiome in liver cirrhosis
-
Qin, N. et al. Alterations of the human gut microbiome in liver cirrhosis. Nature 513, 59-64 (2014).
-
(2014)
Nature
, vol.513
, pp. 59-64
-
-
Qin, N.1
-
92
-
-
66349110620
-
Toll-like receptors as targets in chronic liver diseases
-
Mencin, A., Kluwe, J. & Schwabe, R. F. Toll-like receptors as targets in chronic liver diseases. Gut 58, 704 (2009).
-
(2009)
Gut
, vol.58
, pp. 704
-
-
Mencin, A.1
Kluwe, J.2
Schwabe, R.F.3
-
93
-
-
21344466070
-
+ regulatory T cells
-
+ regulatory T cells. Hepatology 42, 193-199 (2005).
-
(2005)
Hepatology
, vol.42
, pp. 193-199
-
-
Wiegard, C.1
-
94
-
-
0038185316
-
Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells
-
Paik, Y.-H. et al. Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells. Hepatology 37, 1043-1055 (2003).
-
(2003)
Hepatology
, vol.37
, pp. 1043-1055
-
-
Paik, Y.-H.1
-
95
-
-
22544478118
-
+ T cell trapping in the liver
-
+ T cell trapping in the liver. J. Immunol. 175, 1643-1650 (2005).
-
(2005)
J. Immunol.
, vol.175
, pp. 1643-1650
-
-
John, B.1
Crispe, I.N.2
-
96
-
-
84879605175
-
Cellular-specific role of toll-like receptor 4 in hepatic ischemia-reperfusion injury in mice
-
Nace, G. W. et al. Cellular-specific role of toll-like receptor 4 in hepatic ischemia-reperfusion injury in mice. Hepatology 58, 374-387 (2013).
-
(2013)
Hepatology
, vol.58
, pp. 374-387
-
-
Nace, G.W.1
-
97
-
-
34548272744
-
Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis
-
Rivera, C. A. et al. Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis. J. Hepatol. 47, 571-579 (2007).
-
(2007)
J. Hepatol.
, vol.47
, pp. 571-579
-
-
Rivera, C.A.1
-
98
-
-
79959811718
-
Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice
-
Inokuchi, S. et al. Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice. Alcohol. Clin. Exp. Res. 35, 1509-1518 (2011).
-
(2011)
Alcohol. Clin. Exp. Res.
, vol.35
, pp. 1509-1518
-
-
Inokuchi, S.1
-
99
-
-
84891837187
-
Toll-like receptors and liver disease
-
Kesar, V. & Odin, J. A. Toll-like receptors and liver disease. Liver Int. 34, 184-196 (2014).
-
(2014)
Liver Int.
, vol.34
, pp. 184-196
-
-
Kesar, V.1
Odin, J.A.2
-
100
-
-
84901611879
-
Tickling the TLR7 to cure viral hepatitis
-
Funk, E., Kottilil, S., Gilliam, B. & Talwani, R. Tickling the TLR7 to cure viral hepatitis. J. Transl. Med. 12, 129 (2014).
-
(2014)
J. Transl. Med.
, vol.12
, pp. 129
-
-
Funk, E.1
Kottilil, S.2
Gilliam, B.3
Talwani, R.4
-
101
-
-
84878276077
-
GS-9620, an oral agonist of Tolllike receptor-7, induces prolonged suppression of hepatitis B virus in chronically infected chimpanzees
-
Lanford, R. E. et al. GS-9620, an oral agonist of Tolllike receptor-7, induces prolonged suppression of hepatitis B virus in chronically infected chimpanzees. Gastroenterology 144, 1508-1517.e10 (2013).
-
(2013)
Gastroenterology
, vol.144
, pp. 1508-1508e10
-
-
Lanford, R.E.1
-
102
-
-
84956808985
-
-
US National Library of Science. Safety and efficacy of GS-9620 for the treatment of chronic hepatitis B virus in virally-suppressed subjects. ClinicalTrials.gov [online]
-
US National Library of Science. Safety and efficacy of GS-9620 for the treatment of chronic hepatitis B virus in virally-suppressed subjects. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT02166047 (2014).
-
(2014)
-
-
-
103
-
-
61749099391
-
Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome
-
Imaeda, A. B. et al. Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome. J. Clin. Invest. 119, 305-314 (2009).
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 305-314
-
-
Imaeda, A.B.1
-
104
-
-
76649117721
-
Conventional DCs reduce liver ischemia/reperfusion injury in mice via IL-10 secretion
-
Bamboat, Z. M. et al. Conventional DCs reduce liver ischemia/reperfusion injury in mice via IL-10 secretion. J. Clin. Invest. 120, 559-569 (2010).
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 559-569
-
-
Bamboat, Z.M.1
-
105
-
-
73149110853
-
Activation of the complement system in human nonalcoholic fatty liver disease
-
Rensen, S. S. et al. Activation of the complement system in human nonalcoholic fatty liver disease. Hepatology 50, 1809-1817 (2009).
-
(2009)
Hepatology
, vol.50
, pp. 1809-1817
-
-
Rensen, S.S.1
-
106
-
-
84907833288
-
Complement alternative pathway activation in human nonalcoholic steatohepatitis
-
Segers, F. M. et al. Complement alternative pathway activation in human nonalcoholic steatohepatitis. PLoS ONE 9, e110053 (2014).
-
(2014)
PLoS ONE
, vol.9
, pp. e110053
-
-
Segers, F.M.1
-
107
-
-
84907522167
-
Increased activity of the complement system in the liver of patients with alcoholic hepatitis
-
Shen, H., French, B. A., Liu, H., Tillman, B. C. & French, S. W. Increased activity of the complement system in the liver of patients with alcoholic hepatitis. Exp. Mol. Pathol. 97, 338-344 (2014).
-
(2014)
Exp. Mol. Pathol.
, vol.97
, pp. 338-344
-
-
Shen, H.1
French, B.A.2
Liu, H.3
Tillman, B.C.4
French, S.W.5
-
108
-
-
33947320624
-
Differential contributions of C3, C5, and decay-accelerating factor to ethanol-induced fatty liver in mice
-
Pritchard, M. T. et al. Differential contributions of C3, C5, and decay-accelerating factor to ethanol-induced fatty liver in mice. Gastroenterology 132, 1117-1126 (2007).
-
(2007)
Gastroenterology
, vol.132
, pp. 1117-1126
-
-
Pritchard, M.T.1
-
109
-
-
33744998117
-
Complement C3 contributes to ethanol-induced liver steatosis in mice
-
Bykov, I., Junnikkala, S., Pekna, M., Lindros, K. O. & Meri, S. Complement C3 contributes to ethanol-induced liver steatosis in mice. Ann. Med. 38, 280-286 (2006).
-
(2006)
Ann. Med.
, vol.38
, pp. 280-286
-
-
Bykov, I.1
Junnikkala, S.2
Pekna, M.3
Lindros, K.O.4
Meri, S.5
-
110
-
-
77955474503
-
Complement and alcoholic liver disease: Role of C1q in the pathogenesis of ethanol-induced liver injury in mice
-
Cohen, J. I., Roychowdhury, S., McMullen, M. R., Stavitsky, A. B. & Nagy, L. E. Complement and alcoholic liver disease: role of C1q in the pathogenesis of ethanol-induced liver injury in mice. Gastroenterology 139, 664-674.e1 (2010).
-
(2010)
Gastroenterology
, vol.139
, pp. 664-664e1
-
-
Cohen, J.I.1
Roychowdhury, S.2
McMullen, M.R.3
Stavitsky, A.B.4
Nagy, L.E.5
-
111
-
-
84899789058
-
The role of neutrophils in the development of liver diseases
-
Xu, R., Huang, H., Zhang, Z. & Wang, F. S. The role of neutrophils in the development of liver diseases. Cell. Mol. Immunol. 11, 224-231 (2014).
-
(2014)
Cell. Mol. Immunol.
, vol.11
, pp. 224-231
-
-
Xu, R.1
Huang, H.2
Zhang, Z.3
Wang, F.S.4
-
112
-
-
51349126118
-
Physiology and pathophysiology of liver inflammation, damage and repair
-
Ramadori, G., Moriconi, F., Malik, I. & Dudas, J. Physiology and pathophysiology of liver inflammation, damage and repair. J. Physiol. Pharmacol. 59, S107-S117 (2008).
-
(2008)
J. Physiol. Pharmacol.
, vol.59
, pp. S107-S117
-
-
Ramadori, G.1
Moriconi, F.2
Malik, I.3
Dudas, J.4
-
113
-
-
84906535982
-
Roles for chemokines in liver disease
-
Marra, F. & Tacke, F. Roles for chemokines in liver disease. Gastroenterology 147, 577-594.e1 (2014).
-
(2014)
Gastroenterology
, vol.147
, pp. 577-577e1
-
-
Marra, F.1
Tacke, F.2
-
114
-
-
84896405331
-
A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse
-
Moles, A. et al. A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse. J. Hepatol. 60, 782 (2014).
-
(2014)
J. Hepatol.
, vol.60
, pp. 782
-
-
Moles, A.1
-
115
-
-
84868203266
-
Chemokines and mitochondrial products activate neutrophils to amplify organ injury during mouse acute liver failure
-
Marques, P. E. et al. Chemokines and mitochondrial products activate neutrophils to amplify organ injury during mouse acute liver failure. Hepatology 56, 1971-1982 (2012).
-
(2012)
Hepatology
, vol.56
, pp. 1971-1982
-
-
Marques, P.E.1
-
116
-
-
84925763736
-
Molecular mechanisms of NET formation and degradation revealed by intravital imaging in the liver vasculature
-
Kolaczkowska, E. et al. Molecular mechanisms of NET formation and degradation revealed by intravital imaging in the liver vasculature. Nat. Commun. 6, 6673 (2015).
-
(2015)
Nat. Commun.
, vol.6
, pp. 6673
-
-
Kolaczkowska, E.1
-
117
-
-
84866386143
-
Intravascular neutrophil extracellular traps capture bacteria from the bloodstream during sepsis
-
McDonald, B., Urrutia, R., Yipp, B. G., Jenne, C. N. & Kubes, P. Intravascular neutrophil extracellular traps capture bacteria from the bloodstream during sepsis. Cell Host Microbe 12, 324-333 (2012).
-
(2012)
Cell Host Microbe
, vol.12
, pp. 324-333
-
-
McDonald, B.1
Urrutia, R.2
Yipp, B.G.3
Jenne, C.N.4
Kubes, P.5
-
118
-
-
84873918079
-
Neutrophils recruited to sites of infection protect from virus challenge by releasing neutrophil extracellular traps
-
Jenne, C. N. et al. Neutrophils recruited to sites of infection protect from virus challenge by releasing neutrophil extracellular traps. Cell Host Microbe 13, 169-180 (2013).
-
(2013)
Cell Host Microbe
, vol.13
, pp. 169-180
-
-
Jenne, C.N.1
-
119
-
-
0025687478
-
Neutrophils contribute to ischemia/reperfusion injury in rat liver in vivo
-
Jaeschke, H., Farhood, A. & Smith, C. W. Neutrophils contribute to ischemia/reperfusion injury in rat liver in vivo. FASEB J. 4, 3355-3359 (1990).
-
(1990)
FASEB J.
, vol.4
, pp. 3355-3359
-
-
Jaeschke, H.1
Farhood, A.2
Smith, C.W.3
-
120
-
-
0028912405
-
Intercellular adhesion molecule 1 (ICAM-1) expression and its role in neutrophil-induced ischemia-reperfusion injury in rat liver
-
Farhood, A. et al. Intercellular adhesion molecule 1 (ICAM-1) expression and its role in neutrophil-induced ischemia-reperfusion injury in rat liver. J. Leukoc. Biol. 57, 368-374 (1995).
-
(1995)
J. Leukoc. Biol.
, vol.57
, pp. 368-374
-
-
Farhood, A.1
-
121
-
-
84874601937
-
Intravital imaging of neutrophil recruitment in hepatic ischemia-reperfusion injury in mice
-
Honda, M. et al. Intravital imaging of neutrophil recruitment in hepatic ischemia-reperfusion injury in mice. Transplantation 95, 551-558 (2013).
-
(2013)
Transplantation
, vol.95
, pp. 551-558
-
-
Honda, M.1
-
122
-
-
0036017174
-
Neutrophil-mediated tissue injury in alcoholic hepatitis
-
Jaeschke, H. Neutrophil-mediated tissue injury in alcoholic hepatitis. Alcohol 27, 23-27 (2002).
-
(2002)
Alcohol
, vol.27
, pp. 23-27
-
-
Jaeschke, H.1
-
123
-
-
84899560268
-
Metabolically induced liver inflammation leads to NASH and differs from LPS-or IL-1β-induced chronic inflammation
-
Liang, W. et al. Metabolically induced liver inflammation leads to NASH and differs from LPS-or IL-1β-induced chronic inflammation. Lab. Invest. 94, 491-502 (2014).
-
(2014)
Lab. Invest.
, vol.94
, pp. 491-502
-
-
Liang, W.1
-
124
-
-
84886689508
-
IL-17A synergistically enhances bile acid-induced inflammation during obstructive cholestasis
-
O'Brien, K. M. et al. IL-17A synergistically enhances bile acid-induced inflammation during obstructive cholestasis. Am. J. Pathol. 183, 1498-1507 (2013).
-
(2013)
Am. J. Pathol.
, vol.183
, pp. 1498-1507
-
-
O'Brien, K.M.1
-
125
-
-
84886654275
-
Tissue-resident macrophages
-
Davies, L. C., Jenkins, S. J., Allen, J. E. & Taylor, P. R. Tissue-resident macrophages. Nat. Immunol. 14, 986 (2013).
-
(2013)
Nat. Immunol.
, vol.14
, pp. 986
-
-
Davies, L.C.1
Jenkins, S.J.2
Allen, J.E.3
Taylor, P.R.4
-
126
-
-
84920724791
-
Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment
-
Lavin, Y. et al. Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment. Cell 159, 1312-1326 (2014).
-
(2014)
Cell
, vol.159
, pp. 1312-1326
-
-
Lavin, Y.1
-
127
-
-
56749174940
-
Exploring the full spectrum of macrophage activation
-
Mosser, D. M. & Edwards, J. P. Exploring the full spectrum of macrophage activation. Nat. Rev. Immunol. 8, 958-969 (2008).
-
(2008)
Nat. Rev. Immunol.
, vol.8
, pp. 958-969
-
-
Mosser, D.M.1
Edwards, J.P.2
-
128
-
-
80052650727
-
Cutting edge: Immunological consequences and trafficking of human regulatory macrophages administered to renal transplant recipients
-
Hutchinson, J. A. et al. Cutting edge: Immunological consequences and trafficking of human regulatory macrophages administered to renal transplant recipients. J. Immunol. 187, 2072-2078 (2011).
-
(2011)
J. Immunol.
, vol.187
, pp. 2072-2078
-
-
Hutchinson, J.A.1
-
129
-
-
84894102230
-
Transcriptome-based network analysis reveals a spectrum model of human macrophage activation
-
Xue, J. et al. Transcriptome-based network analysis reveals a spectrum model of human macrophage activation. Immunity 40, 274-288 (2014).
-
(2014)
Immunity
, vol.40
, pp. 274-288
-
-
Xue, J.1
-
130
-
-
84904394690
-
Macrophage activation and polarization: Nomenclature and experimental guidelines
-
Murray, P. J. et al. Macrophage activation and polarization: nomenclature and experimental guidelines. Immunity 41, 14-20 (2014).
-
(2014)
Immunity
, vol.41
, pp. 14-20
-
-
Murray, P.J.1
-
131
-
-
84869208905
-
Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis
-
Ramachandran, P. et al. Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis. Proc. Natl Acad. Sci. USA 109, E3186-E3195 (2012).
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. E3186-E3195
-
-
Ramachandran, P.1
-
132
-
-
67651174837
-
+ monocyte subset upon liver injury promotes hepatic fibrosis
-
+ monocyte subset upon liver injury promotes hepatic fibrosis. Hepatology 50, 261-274 (2009).
-
(2009)
Hepatology
, vol.50
, pp. 261-274
-
-
Karlmark, K.R.1
-
133
-
-
84928254123
-
+ monocytes at a site of sterile injury
-
+ monocytes at a site of sterile injury. J. Exp. Med. 212, 447-456 (2015).
-
(2015)
J. Exp. Med.
, vol.212
, pp. 447-456
-
-
Dal-Secco, D.1
-
134
-
-
84903625203
-
Infiltrating monocyte-derived macrophages and resident kupffer cells display different ontogeny and functions in acute liver injury
-
Zigmond, E. et al. Infiltrating monocyte-derived macrophages and resident kupffer cells display different ontogeny and functions in acute liver injury. J. Immunol. 193, 344-353 (2014).
-
(2014)
J. Immunol.
, vol.193
, pp. 344-353
-
-
Zigmond, E.1
-
135
-
-
84871156049
-
Role of galectin-3 in classical and alternative macrophage activation in the liver following acetaminophen intoxication
-
Dragomir, A.-C. D., Sun, R., Choi, H., Laskin, J. D. & Laskin, D. L. Role of galectin-3 in classical and alternative macrophage activation in the liver following acetaminophen intoxication. J. Immunol. 189, 5934-5941 (2012).
-
(2012)
J. Immunol.
, vol.189
, pp. 5934-5941
-
-
Dragomir, A.-C.D.1
Sun, R.2
Choi, H.3
Laskin, J.D.4
Laskin, D.L.5
-
136
-
-
84929274273
-
Immune mechanisms in acetaminophen-induced acute liver failure
-
Krenkel, O., Mossanen, J. C. & Tacke, F. Immune mechanisms in acetaminophen-induced acute liver failure. Hepatobiliary Surg. Nutr. 3, 331-343 (2014).
-
(2014)
Hepatobiliary Surg. Nutr.
, vol.3
, pp. 331-343
-
-
Krenkel, O.1
Mossanen, J.C.2
Tacke, F.3
-
137
-
-
0036913249
-
Protective role of Kupffer cells in acetaminophen-induced hepatic injury in mice
-
Ju, C. et al. Protective role of Kupffer cells in acetaminophen-induced hepatic injury in mice. Chem. Res. Toxicol. 15, 1504-1513 (2002).
-
(2002)
Chem. Res. Toxicol.
, vol.15
, pp. 1504-1513
-
-
Ju, C.1
-
138
-
-
84952928093
-
CSF1 restores innate immunity following liver injury in mice and serum levels indicate outcomes of patients with acute liver failure
-
Stutchfield, B. M. et al. CSF1 restores innate immunity following liver injury in mice and serum levels indicate outcomes of patients with acute liver failure. Gastroenterology http://dx.doi.org/10.1053/j.gastro.2015.08.053 (2015).
-
(2015)
Gastroenterology
-
-
Stutchfield, B.M.1
-
139
-
-
0037686692
-
Hepatic allograft-derived Kupffer cells regulate T cell response in rats
-
Sun, Z. et al. Hepatic allograft-derived Kupffer cells regulate T cell response in rats. Liver Transpl. 9, 489-497 (2003).
-
(2003)
Liver Transpl.
, vol.9
, pp. 489-497
-
-
Sun, Z.1
-
140
-
-
78649464770
-
Kupffer cells promote acute rejection via induction of Th17 differentiation in rat liver allografts
-
Xie, X. et al. Kupffer cells promote acute rejection via induction of Th17 differentiation in rat liver allografts. Transplant. Proc. 42, 3784-3792 (2010).
-
(2010)
Transplant. Proc.
, vol.42
, pp. 3784-3792
-
-
Xie, X.1
-
141
-
-
84924993872
-
Activation of NLRP3 and AIM2 inflammasomes in Kupffer cells in hepatic ischemia/reperfusion
-
Kim, H. Y., Kim, S. J. & Lee, S. M. Activation of NLRP3 and AIM2 inflammasomes in Kupffer cells in hepatic ischemia/reperfusion. FEBS J. 282, 259-270 (2015).
-
(2015)
FEBS J.
, vol.282
, pp. 259-270
-
-
Kim, H.Y.1
Kim, S.J.2
Lee, S.M.3
-
142
-
-
84926323336
-
VEGFR1-positive macrophages facilitate liver repair and sinusoidal reconstruction after hepatic ischemia/reperfusion injury
-
Ohkubo, H. et al. VEGFR1-positive macrophages facilitate liver repair and sinusoidal reconstruction after hepatic ischemia/reperfusion injury. PLoS ONE 9, e105533 (2014).
-
(2014)
PLoS ONE
, vol.9
, pp. e105533
-
-
Ohkubo, H.1
-
143
-
-
77954693077
-
Murine Kupffer cells are protective in total hepatic ischemia/reperfusion injury with bowel congestion through IL-10
-
Ellett, J. D. et al. Murine Kupffer cells are protective in total hepatic ischemia/reperfusion injury with bowel congestion through IL-10. J. Immunol. 184, 5849-5858 (2010).
-
(2010)
J. Immunol.
, vol.184
, pp. 5849-5858
-
-
Ellett, J.D.1
-
144
-
-
84904392112
-
Macrophages immunity, and metabolic disease
-
McNelis, J. C. & Olefsky, J. M. Macrophages, immunity, and metabolic disease. Immunity 41, 36-48 (2014).
-
(2014)
Immunity
, vol.41
, pp. 36-48
-
-
McNelis, J.C.1
Olefsky, J.M.2
-
145
-
-
84894798789
-
M2 Kupffer cells promote M1 Kupffer cell apoptosis: A protective mechanism against alcoholic and nonalcoholic fatty liver disease
-
Wan, J. et al. M2 Kupffer cells promote M1 Kupffer cell apoptosis: a protective mechanism against alcoholic and nonalcoholic fatty liver disease. Hepatology 59, 130-142 (2014).
-
(2014)
Hepatology
, vol.59
, pp. 130-142
-
-
Wan, J.1
-
146
-
-
33144463511
-
Tumour necrosis factor α signalling through activation of Kupffer cells plays an essential role in liver fibrosis of non-alcoholic steatohepatitis in mice
-
Tomita, K. et al. Tumour necrosis factor α signalling through activation of Kupffer cells plays an essential role in liver fibrosis of non-alcoholic steatohepatitis in mice. Gut 55, 415 (2006).
-
(2006)
Gut
, vol.55
, pp. 415
-
-
Tomita, K.1
-
147
-
-
84862669638
-
Toxic lipids stored by Kupffer cells correlates with their pro-inflammatory phenotype at an early stage of steatohepatitis
-
Leroux, A. et al. Toxic lipids stored by Kupffer cells correlates with their pro-inflammatory phenotype at an early stage of steatohepatitis. J. Hepatol. 57, 141-149 (2012).
-
(2012)
J. Hepatol.
, vol.57
, pp. 141-149
-
-
Leroux, A.1
-
148
-
-
84908238878
-
Both bone marrow-derived and non-bone marrow-derived cells contribute to AIM2 and NLRP3 inflammasome activation in a MyD88-dependent manner in dietary steatohepatitis
-
Csak, T. et al. Both bone marrow-derived and non-bone marrow-derived cells contribute to AIM2 and NLRP3 inflammasome activation in a MyD88-dependent manner in dietary steatohepatitis. Liver Int. 34, 1402-1413 (2014).
-
(2014)
Liver Int.
, vol.34
, pp. 1402-1413
-
-
Csak, T.1
-
149
-
-
77953891627
-
Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1β in mice
-
Miura, K. et al. Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1β in mice. Gastroenterology 139, 323-334.e7 (2010).
-
(2010)
Gastroenterology
, vol.139
, pp. 323-323e7
-
-
Miura, K.1
-
150
-
-
84861872575
-
Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2
-
Miura, K., Yang, L., van Rooijen, N., Ohnishi, H. & Seki, E. Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2. Am. J. Physiol. Gastrointest. Liver Physiol. 302, G1310-G1321 (2012).
-
(2012)
Am. J. Physiol. Gastrointest. Liver Physiol.
, vol.302
, pp. G1310-G1321
-
-
Miura, K.1
Yang, L.2
Van Rooijen, N.3
Ohnishi, H.4
Seki, E.5
-
151
-
-
84857055199
-
Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury
-
Baeck, C. et al. Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury. Gut 61, 416-426 (2012).
-
(2012)
Gut
, vol.61
, pp. 416-426
-
-
Baeck, C.1
-
152
-
-
84906314467
-
The role of Kupffer cells in hepatitis B and hepatitis C virus infections
-
Boltjes, A., Movita, D., Boonstra, A. & Woltman, A. M. The role of Kupffer cells in hepatitis B and hepatitis C virus infections. J. Hepatol. 61, 660-671 (2014).
-
(2014)
J. Hepatol.
, vol.61
, pp. 660-671
-
-
Boltjes, A.1
Movita, D.2
Boonstra, A.3
Woltman, A.M.4
-
153
-
-
84928563808
-
Inflammatory monocytes recruited to the liver within 24 hours after virus-induced inflammation resemble Kupffer cells but are functionally distinct
-
Movita, D. et al. Inflammatory monocytes recruited to the liver within 24 hours after virus-induced inflammation resemble Kupffer cells but are functionally distinct. J. Virol. 89, 4809-4817 (2015).
-
(2015)
J. Virol.
, vol.89
, pp. 4809-4817
-
-
Movita, D.1
-
154
-
-
84883533046
-
Mobilizing monocytes to cross-present circulating viral antigen in chronic infection
-
Gehring, A. J. et al. Mobilizing monocytes to cross-present circulating viral antigen in chronic infection. J. Clin. Invest. 123, 3766-3776 (2013).
-
(2013)
J. Clin. Invest.
, vol.123
, pp. 3766-3776
-
-
Gehring, A.J.1
-
155
-
-
84878233150
-
+ T cells and successful immunotherapy against chronic viral liver infection
-
+ T cells and successful immunotherapy against chronic viral liver infection. Nat. Immunol. 14, 574-583 (2013).
-
(2013)
Nat. Immunol.
, vol.14
, pp. 574-583
-
-
Huang, L.R.1
-
156
-
-
72549097659
-
Hepatitis C virus core protein subverts the antiviral activities of human Kupffer cells
-
Tu, Z. et al. Hepatitis C virus core protein subverts the antiviral activities of human Kupffer cells. Gastroenterology 138, 305-314 (2010).
-
(2010)
Gastroenterology
, vol.138
, pp. 305-314
-
-
Tu, Z.1
-
157
-
-
84896494832
-
Activated macrophages promote hepatitis C virus entry in a tumor necrosis factor-dependent manner
-
Fletcher, N. F. et al. Activated macrophages promote hepatitis C virus entry in a tumor necrosis factor-dependent manner. Hepatology 59, 1320-1330 (2014).
-
(2014)
Hepatology
, vol.59
, pp. 1320-1330
-
-
Fletcher, N.F.1
-
158
-
-
84876871333
-
IL-1 (3 production through the NLRP3 inflammasome by hepatic macrophages links hepatitis C virus infection with liver inflammation and disease
-
Negash, A. A. et al. IL-1 (3 production through the NLRP3 inflammasome by hepatic macrophages links hepatitis C virus infection with liver inflammation and disease. PLoS Pathog. 9, e1003330 (2013).
-
(2013)
PLoS Pathog.
, vol.9
, pp. e1003330
-
-
Negash, A.A.1
-
159
-
-
84930651350
-
Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells
-
Pallett, L. J. et al. Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells. Nat. Med. 21, 591-600 (2015).
-
(2015)
Nat. Med.
, vol.21
, pp. 591-600
-
-
Pallett, L.J.1
-
160
-
-
84970918672
-
Emerging roles of myeloid derived suppressor cells in hepatic inflammation and fibrosis
-
Hammerich, L. & Tacke, F Emerging roles of myeloid derived suppressor cells in hepatic inflammation and fibrosis. World J. Gastrointest. Pathophysiol. 6, 43-50 (2015).
-
(2015)
World J. Gastrointest. Pathophysiol.
, vol.6
, pp. 43-50
-
-
Hammerich, L.1
Tacke, F.2
-
161
-
-
84923408433
-
Cyclic adenosine monophosphate-responsive element modulator alpha overexpression impairs function of hepatic myeloid-derived suppressor cells and aggravates immune-mediated hepatitis in mice
-
Hammerich, L. et al. Cyclic adenosine monophosphate-responsive element modulator alpha overexpression impairs function of hepatic myeloid-derived suppressor cells and aggravates immune-mediated hepatitis in mice. Hepatology 61, 990-1002 (2015).
-
(2015)
Hepatology
, vol.61
, pp. 990-1002
-
-
Hammerich, L.1
-
162
-
-
84918555897
-
Myeloid-derived suppressor activity is mediated by monocytic lineages maintained by continuous inhibition of extrinsic and intrinsic death pathways
-
Haverkamp, J. M. et al. Myeloid-derived suppressor activity is mediated by monocytic lineages maintained by continuous inhibition of extrinsic and intrinsic death pathways. Immunity 41, 947-959 (2014).
-
(2014)
Immunity
, vol.41
, pp. 947-959
-
-
Haverkamp, J.M.1
-
163
-
-
79959382649
-
Interleukin-8 is activated in patients with chronic liver diseases and associated with hepatic macrophage accumulation in human liver fibrosis
-
Zimmermann, H. W. et al. Interleukin-8 is activated in patients with chronic liver diseases and associated with hepatic macrophage accumulation in human liver fibrosis. PLoS ONE 6, e21381 (2011).
-
(2011)
PLoS ONE
, vol.6
, pp. e21381
-
-
Zimmermann, H.W.1
-
164
-
-
84872159959
-
Monocyte subsets in human liver disease show distinct phenotypic and functional characteristics
-
Liaskou, E. et al. Monocyte subsets in human liver disease show distinct phenotypic and functional characteristics. Hepatology 57, 385-398 (2013).
-
(2013)
Hepatology
, vol.57
, pp. 385-398
-
-
Liaskou, E.1
-
165
-
-
77952739598
-
+ monocytes across human liver sinusoidal endothelium
-
+ monocytes across human liver sinusoidal endothelium. Hepatology 51, 2030-2039 (2010).
-
(2010)
Hepatology
, vol.51
, pp. 2030-2039
-
-
Aspinall, A.I.1
-
166
-
-
77955096540
-
Functional contribution of elevated circulating and hepatic non-classical CD14CD16 monocytes to inflammation and human liver fibrosis
-
Zimmermann, H. W. et al. Functional contribution of elevated circulating and hepatic non-classical CD14CD16 monocytes to inflammation and human liver fibrosis. PLoS ONE 5, e11049 (2010).
-
(2010)
PLoS ONE
, vol.5
, pp. e11049
-
-
Zimmermann, H.W.1
-
167
-
-
84923917947
-
Patients with acute-on-chronic liver failure have increased numbers of regulatory immune cells expressing the receptor tyrosine kinase MERTK
-
Bernsmeier, C. et al. Patients with acute-on-chronic liver failure have increased numbers of regulatory immune cells expressing the receptor tyrosine kinase MERTK. Gastroenterology 148, 603-615.e14 (2015).
-
(2015)
Gastroenterology
, vol.148
, pp. 603-603e14
-
-
Bernsmeier, C.1
-
168
-
-
84884984479
-
Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice
-
Pradere, J.-P. et al. Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice. Hepatology 58, 1461-1473 (2013).
-
(2013)
Hepatology
, vol.58
, pp. 1461-1473
-
-
Pradere, J.-P.1
-
169
-
-
84894072682
-
CCL2-dependent infiltrating macrophages promote angiogenesis in progressive liver fibrosis
-
Ehling, J. et al. CCL2-dependent infiltrating macrophages promote angiogenesis in progressive liver fibrosis. Gut 63, 1960-1971 (2014).
-
(2014)
Gut
, vol.63
, pp. 1960-1971
-
-
Ehling, J.1
-
170
-
-
84857444883
-
Hepatic macrophage migration and differentiation critical for liver fibrosis is mediated by the chemokine receptor C-C motif chemokine receptor 8 in mice
-
Heymann, F et al. Hepatic macrophage migration and differentiation critical for liver fibrosis is mediated by the chemokine receptor C-C motif chemokine receptor 8 in mice. Hepatology 55, 898-909 (2012).
-
(2012)
Hepatology
, vol.55
, pp. 898-909
-
-
Heymann, F.1
-
171
-
-
78049492110
-
3CR1 protects against liver fibrosis by controlling differentiation and survival of infiltrating hepatic monocytes
-
3CR1 protects against liver fibrosis by controlling differentiation and survival of infiltrating hepatic monocytes. Hepatology 52, 1769-1782 (2010).
-
(2010)
Hepatology
, vol.52
, pp. 1769-1782
-
-
Karlmark, K.R.1
-
172
-
-
79953656140
-
Association of T-zone reticular networks and conduits with ectopic lymphoid tissues in mice and humans
-
Link, A. et al. Association of T-zone reticular networks and conduits with ectopic lymphoid tissues in mice and humans. Am. J. Pathol. 178, 1662-1675 (2011).
-
(2011)
Am. J. Pathol.
, vol.178
, pp. 1662-1675
-
-
Link, A.1
-
173
-
-
33845869847
-
Increasing numbers of hepatic dendritic cells promote HMGB1-mediated ischemia-reperfusion injury
-
Tsung, A. et al. Increasing numbers of hepatic dendritic cells promote HMGB1-mediated ischemia-reperfusion injury. J. Leukoc. Biol. 81, 119-128 (2007).
-
(2007)
J. Leukoc. Biol.
, vol.81
, pp. 119-128
-
-
Tsung, A.1
-
174
-
-
84881028719
-
Dendritic cells limit fibroinflammatory injury in nonalcoholic steatohepatitis in mice
-
Henning, J. R. et al. Dendritic cells limit fibroinflammatory injury in nonalcoholic steatohepatitis in mice. Hepatology 58, 589-602 (2013).
-
(2013)
Hepatology
, vol.58
, pp. 589-602
-
-
Henning, J.R.1
-
175
-
-
77955344402
-
Lipid accumulation and dendritic cell dysfunction in cancer
-
Herber, D. L. et al. Lipid accumulation and dendritic cell dysfunction in cancer. Nat. Med. 16, 880-886 (2010).
-
(2010)
Nat. Med.
, vol.16
, pp. 880-886
-
-
Herber, D.L.1
-
176
-
-
0035182253
-
Regulation by chemokines of circulating dendritic cell precursors, and the formation of portal tract-associated lymphoid tissue, in a granulomatous liver disease
-
Yoneyama, H. et al. Regulation by chemokines of circulating dendritic cell precursors, and the formation of portal tract-associated lymphoid tissue, in a granulomatous liver disease. J. Exp. Med. 193, 35-49 (2001).
-
(2001)
J. Exp. Med.
, vol.193
, pp. 35-49
-
-
Yoneyama, H.1
-
177
-
-
70449355084
-
In liver fibrosis, dendritic cells govern hepatic inflammation in mice via TNF-a
-
Connolly, M. K. et al. In liver fibrosis, dendritic cells govern hepatic inflammation in mice via TNF-a. J. Clin. Invest. 119, 3213-3225 (2009).
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 3213-3225
-
-
Connolly, M.K.1
-
178
-
-
77958124602
-
Tip-DC development during parasitic infection is regulated by IL-10 and requires CCL2/CCR2 IFN-y and MyD88 signaling
-
Bosschaerts, T. et al. Tip-DC development during parasitic infection is regulated by IL-10 and requires CCL2/CCR2, IFN-y and MyD88 signaling. PLoS Pathog. 6, e1001045 (2010).
-
(2010)
PLoS Pathog.
, vol.6
, pp. e1001045
-
-
Bosschaerts, T.1
-
179
-
-
84155175629
-
Dendritic cell regulation of carbon tetrachloride-induced murine liver fibrosis regression
-
Jiao, J. et al. Dendritic cell regulation of carbon tetrachloride-induced murine liver fibrosis regression. Hepatology 55, 244-255 (2012).
-
(2012)
Hepatology
, vol.55
, pp. 244-255
-
-
Jiao, J.1
-
180
-
-
84856677921
-
Role of stress-induced NKG2D ligands in liver diseases
-
Kahraman, A., Fingas, C. D., Syn, W. K., Gerken, G. & Canbay, A. Role of stress-induced NKG2D ligands in liver diseases. Liver Int. 32, 370-382 (2012).
-
(2012)
Liver Int.
, vol.32
, pp. 370-382
-
-
Kahraman, A.1
Fingas, C.D.2
Syn, W.K.3
Gerken, G.4
Canbay, A.5
-
181
-
-
84884990148
-
Invariant NKT cell activation induces neutrophil accumulation and hepatitis: Opposite regulation by IL-4 and IFN-γ
-
Wang, H., Feng, D., Park, O., Yin, S. & Gao, B. Invariant NKT cell activation induces neutrophil accumulation and hepatitis: opposite regulation by IL-4 and IFN-γ. Hepatology 58, 1474-1485 (2013).
-
(2013)
Hepatology
, vol.58
, pp. 1474-1485
-
-
Wang, H.1
Feng, D.2
Park, O.3
Yin, S.4
Gao, B.5
-
182
-
-
84866520055
-
Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production
-
Lynch, L. et al. Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production. Immunity 37, 574-587 (2012).
-
(2012)
Immunity
, vol.37
, pp. 574-587
-
-
Lynch, L.1
-
183
-
-
78149295999
-
Protective role of interleukin-17 in murine NKT cell-driven acute experimental hepatitis
-
Wondimu, Z., Santodomingo-Garzon, T., Le, T. & Swain, M. G. Protective role of interleukin-17 in murine NKT cell-driven acute experimental hepatitis. Am. J. Pathol. 177, 2334-2346 (2010).
-
(2010)
Am. J. Pathol.
, vol.177
, pp. 2334-2346
-
-
Wondimu, Z.1
Santodomingo-Garzon, T.2
Le, T.3
Swain, M.G.4
-
184
-
-
84901033141
-
STAT4 knockout mice are more susceptible to concanavalin A-induced T-cell hepatitis
-
Wang, Y. et al. STAT4 knockout mice are more susceptible to concanavalin A-induced T-cell hepatitis. Am. J. Pathol. 184, 1785-1794 (2014).
-
(2014)
Am. J. Pathol.
, vol.184
, pp. 1785-1794
-
-
Wang, Y.1
-
185
-
-
84863993349
-
Retinoic acid alleviates Con A-induced hepatitis and differentially regulates effector production in NKT cells
-
Lee, K.-A. et al. Retinoic acid alleviates Con A-induced hepatitis and differentially regulates effector production in NKT cells. Eur. J. Immunol. 42, 1685-1694 (2012).
-
(2012)
Eur. J. Immunol.
, vol.42
, pp. 1685-1694
-
-
Lee, K.-A.1
-
186
-
-
65449152565
-
Natural killer T cells regulate the homing of chemokine CXC receptor 3-positive regulatory T cells to the liver in mice
-
Santodomingo-Garzon, T., Han, J., Le, T., Yang, Y. & Swain, M. G. Natural killer T cells regulate the homing of chemokine CXC receptor 3-positive regulatory T cells to the liver in mice. Hepatology 49, 1267-1276 (2009).
-
(2009)
Hepatology
, vol.49
, pp. 1267-1276
-
-
Santodomingo-Garzon, T.1
Han, J.2
Le, T.3
Yang, Y.4
Swain, M.G.5
-
187
-
-
84880276248
-
Pathogenesis of chronic viral hepatitis: Differential roles of T cells and NK cells
-
Rehermann, B. Pathogenesis of chronic viral hepatitis: differential roles of T cells and NK cells. Nat. Med. 19, 859-868 (2013).
-
(2013)
Nat. Med.
, vol.19
, pp. 859-868
-
-
Rehermann, B.1
-
188
-
-
84867218760
-
High expression defines a natural killer cell subset that is potentially involved in control of hepatitis C virus replication and modulation of liver fibrosis
-
High expression defines a natural killer cell subset that is potentially involved in control of hepatitis C virus replication and modulation of liver fibrosis. Hepatology 56, 1201-1213 (2012).
-
(2012)
Hepatology
, vol.56
, pp. 1201-1213
-
-
Krämer, B.1
-
189
-
-
84863615340
-
The CXCR3+CD56Bright phenotype characterizes a distinct NK cell subset with anti-fibrotic potential that shows dys-regulated activity in hepatitis C
-
Eisenhardt, M. et al. The CXCR3+CD56Bright phenotype characterizes a distinct NK cell subset with anti-fibrotic potential that shows dys-regulated activity in hepatitis C. PLoS ONE 7, e38846 (2012).
-
(2012)
PLoS ONE
, vol.7
, pp. e38846
-
-
Eisenhardt, M.1
-
190
-
-
84867218760
-
High expression defines a natural killer cell subset that is potentially involved in control of hepatitis C virus replication and modulation of liver fibrosis
-
High expression defines a natural killer cell subset that is potentially involved in control of hepatitis C virus replication and modulation of liver fibrosis. Hepatology 56, 1201-1213 (2012).
-
(2012)
Hepatology
, vol.56
, pp. 1201-1213
-
-
Kramer, B.1
-
191
-
-
33947411395
-
Cytokines induced during chronic hepatitis B virus infection promote a pathway for NK cell-mediated liver damage
-
Dunn, C. et al. Cytokines induced during chronic hepatitis B virus infection promote a pathway for NK cell-mediated liver damage. J. Exp. Med. 204, 667-680 (2007).
-
(2007)
J. Exp. Med.
, vol.204
, pp. 667-680
-
-
Dunn, C.1
-
192
-
-
84874543706
-
Up-regulation of a death receptor renders antiviral T cells susceptible to NK cell-mediated deletion
-
Peppa, D. et al. Up-regulation of a death receptor renders antiviral T cells susceptible to NK cell-mediated deletion. J. Exp. Med. 210, 99-114 (2013).
-
(2013)
J. Exp. Med.
, vol.210
, pp. 99-114
-
-
Peppa, D.1
-
193
-
-
84863707404
-
Hepatitis B virus-induced lipid alterations contribute to natural killer T cell-dependent protective immunity
-
Zeissig, S. et al. Hepatitis B virus-induced lipid alterations contribute to natural killer T cell-dependent protective immunity. Nat. Med. 18, 1060-1068 (2012).
-
(2012)
Nat. Med.
, vol.18
, pp. 1060-1068
-
-
Zeissig, S.1
-
194
-
-
33846798498
-
CD1 expression and CD1-restricted T cell activity in normal and tumour-bearing human liver
-
Kenna, T. et al. CD1 expression and CD1-restricted T cell activity in normal and tumour-bearing human liver. Cancer Immunol. Immunother. 56, 563-572 (2007).
-
(2007)
Cancer Immunol. Immunother.
, vol.56
, pp. 563-572
-
-
Kenna, T.1
-
195
-
-
84942553335
-
The biliary epithelium presents antigens to and activates natural killer T cells
-
Schrumpf, E. et al. The biliary epithelium presents antigens to and activates natural killer T cells. Hepatology 62, 1249-1259 (2015).
-
(2015)
Hepatology
, vol.62
, pp. 1249-1259
-
-
Schrumpf, E.1
-
196
-
-
84901331442
-
The liver may act as a firewall mediating mutualism between the host and its gut commensal microbiota
-
Balmer, M. L. et al. The liver may act as a firewall mediating mutualism between the host and its gut commensal microbiota. Sci. Transl. Med. 6, 237ra66 (2014).
-
(2014)
Sci. Transl. Med.
, vol.6
, pp. 237ra66
-
-
Balmer, M.L.1
-
197
-
-
84925362128
-
IL-22 and IL-22 binding protein (IL-22BP) regulate fibrosis and cirrhosis in hepatitis C virus and schistosome infections
-
Sertorio, M. et al. IL-22 and IL-22 binding protein (IL-22BP) regulate fibrosis and cirrhosis in hepatitis C virus and schistosome infections. Hepatology 61, 1321-1331 (2015).
-
(2015)
Hepatology
, vol.61
, pp. 1321-1331
-
-
Sertorio, M.1
-
198
-
-
84865564349
-
Interleukin-22 induces hepatic stellate cell senescence and restricts liver fibrosis in mice
-
Kong, X. et al. Interleukin-22 induces hepatic stellate cell senescence and restricts liver fibrosis in mice. Hepatology 56, 1150-1159 (2012).
-
(2012)
Hepatology
, vol.56
, pp. 1150-1159
-
-
Kong, X.1
-
199
-
-
84860596931
-
NKp46-mediated killing of human and mouse hepatic stellate cells attenuates liver fibrosis
-
Gur, C. et al. NKp46-mediated killing of human and mouse hepatic stellate cells attenuates liver fibrosis. Gut 61, 885-893 (2012).
-
(2012)
Gut
, vol.61
, pp. 885-893
-
-
Gur, C.1
-
200
-
-
84892394789
-
Natural killer cell-dependent anti-fibrotic pathway in liver injury via Toll-like receptor-9
-
Abu-Tair, L. et al. Natural killer cell-dependent anti-fibrotic pathway in liver injury via Toll-like receptor-9. PLoS ONE 8, e82571 (2013).
-
(2013)
PLoS ONE
, vol.8
, pp. e82571
-
-
Abu-Tair, L.1
-
201
-
-
66149098871
-
Diverse roles of invariant natural killer T cells in liver injury and fibrosis induced by carbon tetrachloride
-
Park, O. et al. Diverse roles of invariant natural killer T cells in liver injury and fibrosis induced by carbon tetrachloride. Hepatology 49, 1683-1694 (2009).
-
(2009)
Hepatology
, vol.49
, pp. 1683-1694
-
-
Park, O.1
-
202
-
-
77952730087
-
Accumulation of natural killer T cells in progressive nonalcoholic fatty liver disease
-
Syn, W. K. et al. Accumulation of natural killer T cells in progressive nonalcoholic fatty liver disease. Hepatology 51, 1998-2007 (2010).
-
(2010)
Hepatology
, vol.51
, pp. 1998-2007
-
-
Syn, W.K.1
-
203
-
-
84907976095
-
+ T cells and NKT cells causes nonalcoholic steatohepatitis and liver cancer via cross-talk with hepatocytes
-
+ T cells and NKT cells causes nonalcoholic steatohepatitis and liver cancer via cross-talk with hepatocytes. Cancer Cell 26, 549-564 (2014).
-
(2014)
Cancer Cell
, vol.26
, pp. 549-564
-
-
Wolf, M.J.1
-
204
-
-
77954701928
-
Human mucosal associated invariant T cells detect bacterially infected cells
-
Gold, M. C. et al. Human mucosal associated invariant T cells detect bacterially infected cells. PLoS Biol. 8, e1000407 (2010).
-
(2010)
PLoS Biol.
, vol.8
, pp. e1000407
-
-
Gold, M.C.1
-
205
-
-
84887281193
-
MAIT cells detect and efficiently lyse bacterially-infected epithelial cells
-
Le Bourhis, L. et al. MAIT cells detect and efficiently lyse bacterially-infected epithelial cells. PLoS Pathog. 9, e1003681 (2013).
-
(2013)
PLoS Pathog.
, vol.9
, pp. e1003681
-
-
Le Bourhis, L.1
-
206
-
-
62349099352
-
Hepatic interleukin-7 expression regulates T cell responses
-
Sawa, Y. et al. Hepatic interleukin-7 expression regulates T cell responses. Immunity 30, 447-457 (2009).
-
(2009)
Immunity
, vol.30
, pp. 447-457
-
-
Sawa, Y.1
-
207
-
-
84903482908
-
Toll-like receptor 8 agonist and bacteria trigger potent activation of innate immune cells in human liver
-
Jo, J. et al. Toll-like receptor 8 agonist and bacteria trigger potent activation of innate immune cells in human liver. PLoS Pathog. 10, e1004210 (2014).
-
(2014)
PLoS Pathog.
, vol.10
, pp. e1004210
-
-
Jo, J.1
-
208
-
-
0025881160
-
Memory T cells represent the predominant lymphocyte subset in acute and chronic liver inflammation
-
Volpes, R., van den Oord, J. J. & Desmet, V. J. Memory T cells represent the predominant lymphocyte subset in acute and chronic liver inflammation. Hepatology 13, 826-829 (1991).
-
(1991)
Hepatology
, vol.13
, pp. 826-829
-
-
Volpes, R.1
Van Den Oord, J.J.2
Desmet, V.J.3
-
209
-
-
84875809649
-
Liver-primed memory T cells generated under noninflammatory conditions provide anti-infectious immunity
-
Bottcher, J. P. et al. Liver-primed memory T cells generated under noninflammatory conditions provide anti-infectious immunity. Cell Rep. 3, 779-795 (2013).
-
(2013)
Cell Rep.
, vol.3
, pp. 779-795
-
-
Bottcher, J.P.1
-
210
-
-
84932110028
-
Intrahepatic regulatory T cells in autoimmune hepatitis are associated with treatment response and depleted with current therapies
-
Taubert, R. et al. Intrahepatic regulatory T cells in autoimmune hepatitis are associated with treatment response and depleted with current therapies. J. Hepatol. 61, 1106-1114 (2014).
-
(2014)
J. Hepatol.
, vol.61
, pp. 1106-1114
-
-
Taubert, R.1
-
211
-
-
77956643943
-
A multifaceted imbalance of T cells with regulatory function characterizes type 1 autoimmune hepatitis
-
Ferri, S. et al. A multifaceted imbalance of T cells with regulatory function characterizes type 1 autoimmune hepatitis. Hepatology 52, 999-1007 (2010).
-
(2010)
Hepatology
, vol.52
, pp. 999-1007
-
-
Ferri, S.1
-
212
-
-
84919442232
-
Role of gamma-delta T cells in liver inflammation and fibrosis
-
Hammerich, L. & Tacke, F. Role of gamma-delta T cells in liver inflammation and fibrosis. World J. Gastrointest. Pathophysiol. 5, 107-113 (2014).
-
(2014)
World J. Gastrointest. Pathophysiol.
, vol.5
, pp. 107-113
-
-
Hammerich, L.1
Tacke, F.2
-
213
-
-
84979850744
-
The concanavalin A model of acute hepatitis in mice
-
Heymann, F., Hamesch, K., Weiskirchen, R. & Tacke, F. The concanavalin A model of acute hepatitis in mice. Lab. Anim. 49, 12-20 (2015).
-
(2015)
Lab. Anim.
, vol.49
, pp. 12-20
-
-
Heymann, F.1
Hamesch, K.2
Weiskirchen, R.3
Tacke, F.4
-
214
-
-
0026643743
-
T cell-dependent experimental liver injury in mice inducible by concanavalin A
-
Tiegs, G., Hentschel, J. & Wendel, A. A. T cell-dependent experimental liver injury in mice inducible by concanavalin A. J. Clin. Invest. 90, 196-203 (1992).
-
(1992)
J. Clin. Invest.
, vol.90
, pp. 196-203
-
-
Tiegs, G.1
Hentschel, J.2
Wendel, A.A.3
-
215
-
-
84888374898
-
Hepatocytes contribute to immune regulation in the liver by activation of the Notch signaling pathway in T cells
-
Burghardt, S. et al. Hepatocytes contribute to immune regulation in the liver by activation of the Notch signaling pathway in T cells. J. Immunol. 191, 5574-5582 (2013).
-
(2013)
J. Immunol.
, vol.191
, pp. 5574-5582
-
-
Burghardt, S.1
-
216
-
-
84893650001
-
Chemokine receptor CCR6-dependent accumulation of γδ T cells in injured liver restricts hepatic inflammation and fibrosis
-
Hammerich, L. et al. Chemokine receptor CCR6-dependent accumulation of γδ T cells in injured liver restricts hepatic inflammation and fibrosis. Hepatology 59, 630-642 (2014).
-
(2014)
Hepatology
, vol.59
, pp. 630-642
-
-
Hammerich, L.1
-
217
-
-
84947078226
-
From immunosuppression to tolerance
-
Adams, D. H., Sanchez-Fueyo, A. & Samuel, D. From immunosuppression to tolerance. J. Hepatol. 62, S170-S185 (2015).
-
(2015)
J. Hepatol.
, vol.62
, pp. S170-S185
-
-
Adams, D.H.1
Sanchez-Fueyo, A.2
Samuel, D.3
-
218
-
-
33344467532
-
+ T cells activated locally within the transplanted liver
-
+ T cells activated locally within the transplanted liver. J. Exp. Med. 203, 437-447 (2006).
-
(2006)
J. Exp. Med.
, vol.203
, pp. 437-447
-
-
Klein, I.1
Crispe, I.N.2
-
219
-
-
72949086418
-
CD4 T cells promote tissue inflammation via CD40 signaling without de novo activation in a murine model of liver ischemia/reperfusion injury
-
Shen, X. et al. CD4 T cells promote tissue inflammation via CD40 signaling without de novo activation in a murine model of liver ischemia/reperfusion injury. Hepatology 50, 1537-1546 (2009).
-
(2009)
Hepatology
, vol.50
, pp. 1537-1546
-
-
Shen, X.1
-
220
-
-
84921496569
-
Immunological aspects of antiviral therapy of chronic hepatitis B virus and hepatitis C virus infections
-
Rehermann, B. & Bertoletti, A. Immunological aspects of antiviral therapy of chronic hepatitis B virus and hepatitis C virus infections. Hepatology 61, 712-721 (2015).
-
(2015)
Hepatology
, vol.61
, pp. 712-721
-
-
Rehermann, B.1
Bertoletti, A.2
-
221
-
-
77956630526
-
+ T cells by adeno-associated virus-transduced hepatocytes
-
+ T cells by adeno-associated virus-transduced hepatocytes. Hepatology 52, 1068-1077 (2010).
-
(2010)
Hepatology
, vol.52
, pp. 1068-1077
-
-
Wuensch, S.A.1
Spahn, J.2
Crispe, I.N.3
-
222
-
-
80055007453
-
+ T-cell immunity to adeno-associated virus can result in prolonged liver injury and fibrogenesis
-
+ T-cell immunity to adeno-associated virus can result in prolonged liver injury and fibrogenesis. Am. J. Pathol. 179, 2370-2381 (2011).
-
(2011)
Am. J. Pathol.
, vol.179
, pp. 2370-2381
-
-
Spahn, J.1
Pierce, R.H.2
Crispe, I.N.3
-
223
-
-
30744437415
-
Platelets mediate cytotoxic T lymphocyte-induced liver damage
-
Iannacone, M. et al. Platelets mediate cytotoxic T lymphocyte-induced liver damage. Nat. Med. 11, 1167-1169 (2005).
-
(2005)
Nat. Med.
, vol.11
, pp. 1167-1169
-
-
Iannacone, M.1
-
224
-
-
84935488734
-
+ T cells
-
+ T cells. Cell 161, 486-500 (2015).
-
(2015)
Cell
, vol.161
, pp. 486-500
-
-
Guidotti, L.G.1
-
226
-
-
84882845968
-
+ T cell stimulation of NK cell anti-fibrotic activity may contribute to accelerated liver fibrosis progression in HIV/HCV patients
-
+ T cell stimulation of NK cell anti-fibrotic activity may contribute to accelerated liver fibrosis progression in HIV/HCV patients. J. Hepatol. 59, 427-433 (2013).
-
(2013)
J. Hepatol.
, vol.59
, pp. 427-433
-
-
Glässner, A.1
-
227
-
-
84905984580
-
+ T cell exhaustion in hepatitis B virus-induced immunotolerance
-
+ T cell exhaustion in hepatitis B virus-induced immunotolerance. J. Immunol. 193, 1645-1653 (2014).
-
(2014)
J. Immunol.
, vol.193
, pp. 1645-1653
-
-
Kong, X.1
Sun, R.2
Chen, Y.3
Wei, H.4
Tian, Z.5
-
228
-
-
80053651902
-
Interleukin-17 exacerbates hepatic steatosis and inflammation in non-alcoholic fatty liver disease
-
Tang, Y. et al. Interleukin-17 exacerbates hepatic steatosis and inflammation in non-alcoholic fatty liver disease. Clin. Exp. Immunol. 166, 281-290 (2011).
-
(2011)
Clin. Exp. Immunol.
, vol.166
, pp. 281-290
-
-
Tang, Y.1
-
229
-
-
84896722464
-
Adaptive immune responses triggered by oxidative stress contribute to hepatic inflammation in NASH
-
Sutti, S. et al. Adaptive immune responses triggered by oxidative stress contribute to hepatic inflammation in NASH. Hepatology 59, 886-897 (2014).
-
(2014)
Hepatology
, vol.59
, pp. 886-897
-
-
Sutti, S.1
-
230
-
-
84927761703
-
Dual role of B7 costimulation in obesity-related nonalcoholic steatohepatitis and metabolic dysregulation
-
Chatzigeorgiou, A. et al. Dual role of B7 costimulation in obesity-related nonalcoholic steatohepatitis and metabolic dysregulation. Hepatology 60, 1196-1210 (2014).
-
(2014)
Hepatology
, vol.60
, pp. 1196-1210
-
-
Chatzigeorgiou, A.1
-
231
-
-
34447503805
-
Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid
-
Mucida, D. et al. Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science 317, 256-260 (2007).
-
(2007)
Science
, vol.317
, pp. 256-260
-
-
Mucida, D.1
-
232
-
-
84884836878
-
Biliary obstruction results in PD-1-dependent liver T cell dysfunction and acute inflammation mediated by Th17 cells and neutrophils
-
Licata, L. A. et al. Biliary obstruction results in PD-1-dependent liver T cell dysfunction and acute inflammation mediated by Th17 cells and neutrophils. J. Leukoc. Biol. 94, 813-823 (2013).
-
(2013)
J. Leukoc. Biol.
, vol.94
, pp. 813-823
-
-
Licata, L.A.1
-
233
-
-
84894728578
-
Cannabinoid receptor 2 counteracts interleukin-17-induced immune and fibrogenic responses in mouse liver
-
Guillot, A. et al. Cannabinoid receptor 2 counteracts interleukin-17-induced immune and fibrogenic responses in mouse liver. Hepatology 59, 296-306 (2014).
-
(2014)
Hepatology
, vol.59
, pp. 296-306
-
-
Guillot, A.1
-
234
-
-
33745003240
-
CB1 cannabinoid receptor antagonism: A new strategy for the treatment of liver fibrosis
-
Teixeira-Clerc, F. et al. CB1 cannabinoid receptor antagonism: a new strategy for the treatment of liver fibrosis. Nat. Med. 12, 671-676 (2006).
-
(2006)
Nat. Med.
, vol.12
, pp. 671-676
-
-
Teixeira-Clerc, F.1
-
235
-
-
81855209855
-
Accelerated and progressive and lethal liver fibrosis in mice that lack interleukin (IL)-10, IL-12p40, and IL-13R α2
-
Mentink-Kane, M. M. et al. Accelerated and progressive and lethal liver fibrosis in mice that lack interleukin (IL)-10, IL-12p40, and IL-13R α2. Gastroenterology 141, 2200-2209 (2011).
-
(2011)
Gastroenterology
, vol.141
, pp. 2200-2209
-
-
Mentink-Kane, M.M.1
-
236
-
-
84923855044
-
Blockade of PD1 and TIM3 restores innate and adaptive immunity in patients with acute alcoholic hepatitis
-
Markwick, L. J. L. et al. Blockade of PD1 and TIM3 restores innate and adaptive immunity in patients with acute alcoholic hepatitis. Gastroenterology 148, 590-602.e10 (2015).
-
(2015)
Gastroenterology
, vol.148
, pp. 590-590e10
-
-
Markwick, L.J.L.1
-
237
-
-
79955565441
-
Fibrosis is regulated by Th2 and Th17 responses and by dynamic interactions between fibroblasts and macrophages
-
Barron, L. & Wynn, T. A. Fibrosis is regulated by Th2 and Th17 responses and by dynamic interactions between fibroblasts and macrophages. Am. J. Physiol. Gastrointest. Liver Physiol. 300, G723-G728 (2011).
-
(2011)
Am. J. Physiol. Gastrointest. Liver Physiol.
, vol.300
, pp. G723-G728
-
-
Barron, L.1
Wynn, T.A.2
-
238
-
-
84881393577
-
IL-17A plays a critical role in the pathogenesis of liver fibrosis through hepatic stellate cell activation
-
Tan, Z. et al. IL-17A plays a critical role in the pathogenesis of liver fibrosis through hepatic stellate cell activation. J. Immunol. 191, 1835-1844 (2013).
-
(2013)
J. Immunol.
, vol.191
, pp. 1835-1844
-
-
Tan, Z.1
-
239
-
-
84866180909
-
Gut-derived lipopolysaccharide promotes T-cell-mediated hepatitis in mice through Toll-like receptor 4
-
Lin, Y. et al. Gut-derived lipopolysaccharide promotes T-cell-mediated hepatitis in mice through Toll-like receptor 4. Cancer Prev. Res. (Phila.) 5, 1090-1102 (2012).
-
(2012)
Cancer Prev. Res. (Phila.)
, vol.5
, pp. 1090-1102
-
-
Lin, Y.1
-
240
-
-
84865461464
-
Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice
-
Meng, F. et al. Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice. Gastroenterology 143, 765-776.e1-3 (2012).
-
(2012)
Gastroenterology
, vol.143
, pp. 765-776e13
-
-
Meng, F.1
-
241
-
-
84896806249
-
Liver fibrosis and repair: Immune regulation of wound healing in a solid organ
-
Pellicoro, A., Ramachandran, P., Iredale, J. P. & Fallowfield, J. A. Liver fibrosis and repair: immune regulation of wound healing in a solid organ. Nat. Rev. Immunol. 14, 181-194 (2014).
-
(2014)
Nat. Rev. Immunol.
, vol.14
, pp. 181-194
-
-
Pellicoro, A.1
Ramachandran, P.2
Iredale, J.P.3
Fallowfield, J.A.4
-
242
-
-
84892469998
-
CCL20 mediates lipopolysaccharide induced liver injury and is a potential driver of inflammation and fibrosis in alcoholic hepatitis
-
Affò, S. et al. CCL20 mediates lipopolysaccharide induced liver injury and is a potential driver of inflammation and fibrosis in alcoholic hepatitis. Gut 63, 1782-1792 (2014).
-
(2014)
Gut
, vol.63
, pp. 1782-1792
-
-
Affò, S.1
-
243
-
-
84859812538
-
Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4
-
Dapito, D. H. et al. Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4. Cancer Cell 21, 504-516 (2012).
-
(2012)
Cancer Cell
, vol.21
, pp. 504-516
-
-
Dapito, D.H.1
-
244
-
-
84941944562
-
Mechanisms of liver fibrosis resolution
-
Tacke, F. & Trautwein, C. Mechanisms of liver fibrosis resolution. J. Hepatol. 63, 1038-1039 (2015).
-
(2015)
J. Hepatol.
, vol.63
, pp. 1038-1039
-
-
Tacke, F.1
Trautwein, C.2
-
245
-
-
79955701910
-
Scraping fibrosis: Expressway to the core of fibrosis
-
Mehal, W. Z., Iredale, J. & Friedman, S. L. Scraping fibrosis: expressway to the core of fibrosis. Nat. Med. 17, 552-553 (2011).
-
(2011)
Nat. Med.
, vol.17
, pp. 552-553
-
-
Mehal, W.Z.1
Iredale, J.2
Friedman, S.L.3
-
246
-
-
84930654452
-
Hepatic fibrosis: Concept to treatment
-
Trautwein, C., Friedman, S. L., Schuppan, D. & Pinzani, M. Hepatic fibrosis: concept to treatment. J. Hepatol. 62, S15-S24 (2015).
-
(2015)
J. Hepatol.
, vol.62
, pp. S15-S24
-
-
Trautwein, C.1
Friedman, S.L.2
Schuppan, D.3
Pinzani, M.4
-
247
-
-
84928910362
-
Role of lymphocytes in liver cancer
-
Mossanen, J. C. & Tacke, F. Role of lymphocytes in liver cancer. Oncoimmunology 2, e26468 (2013).
-
(2013)
Oncoimmunology
, vol.2
, pp. e26468
-
-
Mossanen, J.C.1
Tacke, F.2
-
248
-
-
84929606405
-
Resolution of liver fibrosis requires myeloid cell-driven sinusoidal angiogenesis
-
Kantari-Mimoun, C. et al. Resolution of liver fibrosis requires myeloid cell-driven sinusoidal angiogenesis. Hepatology 61, 2042-2055 (2014).
-
(2014)
Hepatology
, vol.61
, pp. 2042-2055
-
-
Kantari-Mimoun, C.1
|