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Volumn 13, Issue 2, 2016, Pages 88-110

Immunology in the liver-from homeostasis to disease

Author keywords

[No Author keywords available]

Indexed keywords

ALARMIN; COMPLEMENT; HIGH MOBILITY GROUP B1 PROTEIN; INFLAMMASOME; INTERLEUKIN 33; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9;

EID: 84956782591     PISSN: 17595045     EISSN: 17595053     Source Type: Journal    
DOI: 10.1038/nrgastro.2015.200     Document Type: Review
Times cited : (825)

References (248)
  • 1
    • 80052468996 scopus 로고    scopus 로고
    • Mechanisms balancing tolerance and immunity in the liver
    • Bottcher, J. P., Knolle, P. A. & Stabenow, D. Mechanisms balancing tolerance and immunity in the liver. Dig. Dis. 29, 384-390 (2011).
    • (2011) Dig. Dis. , vol.29 , pp. 384-390
    • Bottcher, J.P.1    Knolle, P.A.2    Stabenow, D.3
  • 2
    • 33644544110 scopus 로고    scopus 로고
    • The liver as an immunological organ
    • Racanelli, V. & Rehermann, B. The liver as an immunological organ. Hepatology 43, S54-S62 (2006).
    • (2006) Hepatology , vol.43 , pp. S54-S62
    • Racanelli, V.1    Rehermann, B.2
  • 3
    • 67349182474 scopus 로고    scopus 로고
    • Operational tolerance after liver transplantation
    • Orlando, G., Soker, S. & Wood, K. Operational tolerance after liver transplantation. J. Hepatol. 50, 1247-1257 (2009).
    • (2009) J. Hepatol. , vol.50 , pp. 1247-1257
    • Orlando, G.1    Soker, S.2    Wood, K.3
  • 4
    • 84898936752 scopus 로고    scopus 로고
    • Hepatic immune regulation and its involvement in viral hepatitis infection
    • Knolle, P. A. & Thimme, R. Hepatic immune regulation and its involvement in viral hepatitis infection. Gastroenterology 146, 1193-1207 (2014).
    • (2014) Gastroenterology , vol.146 , pp. 1193-1207
    • Knolle, P.A.1    Thimme, R.2
  • 5
    • 67650750880 scopus 로고    scopus 로고
    • The liver as a lymphoid organ
    • Crispe, I. N. The liver as a lymphoid organ. Annu. Rev. Immunol. 27, 147-163 (2009).
    • (2009) Annu. Rev. Immunol. , vol.27 , pp. 147-163
    • Crispe, I.N.1
  • 6
    • 0033779915 scopus 로고    scopus 로고
    • Endotoxin and cytokine regulation of toll-like receptor (TLR) 2 and TLR4 gene expression in murine liver and hepatocytes
    • Matsumura, T., Ito, A., Takii, T., Hayashi, H. & Onozaki, K. Endotoxin and cytokine regulation of toll-like receptor (TLR) 2 and TLR4 gene expression in murine liver and hepatocytes. J. Interferon Cytokine Res. 20, 915-921 (2000).
    • (2000) J. Interferon Cytokine Res. , vol.20 , pp. 915-921
    • Matsumura, T.1    Ito, A.2    Takii, T.3    Hayashi, H.4    Onozaki, K.5
  • 7
    • 35948958955 scopus 로고    scopus 로고
    • TLR4 enhances TGF-β signaling and hepatic fibrosis
    • Seki, E. et al. TLR4 enhances TGF-β signaling and hepatic fibrosis. Nat. Med. 13, 1324-1332 (2007).
    • (2007) Nat. Med. , vol.13 , pp. 1324-1332
    • Seki, E.1
  • 8
    • 77958557979 scopus 로고    scopus 로고
    • Antigen-presenting cell function in the tolerogenic liver environment
    • Thomson, A. W. & Knolle, P. A. Antigen-presenting cell function in the tolerogenic liver environment. Nat. Rev. Immunol. 10, 753-766 (2010).
    • (2010) Nat. Rev. Immunol. , vol.10 , pp. 753-766
    • Thomson, A.W.1    Knolle, P.A.2
  • 9
    • 84899960512 scopus 로고    scopus 로고
    • Pathology of the liver sinusoids
    • Brunt, E. M. et al. Pathology of the liver sinusoids. Histopathology 64, 907-920 (2014).
    • (2014) Histopathology , vol.64 , pp. 907-920
    • Brunt, E.M.1
  • 10
    • 84870877532 scopus 로고    scopus 로고
    • Functional role of monocytes and macrophages for the inflammatory response in acute liver injury
    • Zimmermann, H. W., Trautwein, C. & Tacke, F. Functional role of monocytes and macrophages for the inflammatory response in acute liver injury. Front. Physiol. 3, 56 (2012).
    • (2012) Front. Physiol. , vol.3 , pp. 56
    • Zimmermann, H.W.1    Trautwein, C.2    Tacke, F.3
  • 11
    • 84926659037 scopus 로고    scopus 로고
    • The complex myeloid network of the liver with diverse functional capacity at steady state and in inflammation
    • Eckert, C., Klein, N., Kornek, M. & Lukacs-Kornek, V. The complex myeloid network of the liver with diverse functional capacity at steady state and in inflammation. Front. Immunol. 6, 179 (2015).
    • (2015) Front. Immunol. , vol.6 , pp. 179
    • Eckert, C.1    Klein, N.2    Kornek, M.3    Lukacs-Kornek, V.4
  • 12
    • 70149090633 scopus 로고    scopus 로고
    • Liver natural killer and natural killer T cells: Immunobiology and emerging roles in liver diseases
    • Gao, B., Radaeva, S. & Park, O. Liver natural killer and natural killer T cells: immunobiology and emerging roles in liver diseases. J. Leukoc. Biol. 86, 513-528 (2009).
    • (2009) J. Leukoc. Biol. , vol.86 , pp. 513-528
    • Gao, B.1    Radaeva, S.2    Park, O.3
  • 13
    • 84898789996 scopus 로고    scopus 로고
    • Macrophage heterogeneity in liver injury and fibrosis
    • Tacke, F. & Zimmermann, H. W. Macrophage heterogeneity in liver injury and fibrosis. J. Hepatol. 60, 1090-1096 (2014).
    • (2014) J. Hepatol. , vol.60 , pp. 1090-1096
    • Tacke, F.1    Zimmermann, H.W.2
  • 14
    • 58149388026 scopus 로고    scopus 로고
    • Origins and tissue-context-dependent fates of blood monocytes
    • Varol, C., Yona, S. & Jung, S. Origins and tissue-context-dependent fates of blood monocytes. Immunol. Cell Biol. 87, 30-38 (2009).
    • (2009) Immunol. Cell Biol. , vol.87 , pp. 30-38
    • Varol, C.1    Yona, S.2    Jung, S.3
  • 15
    • 84925465211 scopus 로고    scopus 로고
    • Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors
    • Gomez Perdiguero, E. et al. Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors. Nature 518, 547-551 (2015).
    • (2015) Nature , vol.518 , pp. 547-551
    • Gomez Perdiguero, E.1
  • 16
    • 84872765982 scopus 로고    scopus 로고
    • Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis
    • Yona, S. et al. Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis. Immunity 38, 79-91 (2013).
    • (2013) Immunity , vol.38 , pp. 79-91
    • Yona, S.1
  • 17
    • 84859508307 scopus 로고    scopus 로고
    • A lineage of myeloid cells independent of Myb and hematopoietic stem cells
    • Schulz, C. et al. A lineage of myeloid cells independent of Myb and hematopoietic stem cells. Science 336, 86-90 (2012).
    • (2012) Science , vol.336 , pp. 86-90
    • Schulz, C.1
  • 18
    • 84864351457 scopus 로고    scopus 로고
    • Source and characterization of hepatic macrophages in acetaminophen-induced acute liver failure in humans
    • Antoniades, C. G. et al. Source and characterization of hepatic macrophages in acetaminophen-induced acute liver failure in humans. Hepatology 56, 735-746 (2012).
    • (2012) Hepatology , vol.56 , pp. 735-746
    • Antoniades, C.G.1
  • 19
    • 84865418665 scopus 로고    scopus 로고
    • Deciphering the transcriptional network of the dendritic cell lineage
    • Miller, J. C. et al. Deciphering the transcriptional network of the dendritic cell lineage. Nat. Immunol. 13, 888-899 (2012).
    • (2012) Nat. Immunol. , vol.13 , pp. 888-899
    • Miller, J.C.1
  • 20
  • 21
    • 61449193205 scopus 로고    scopus 로고
    • Human liver dendritic cells promote T cell hyporesponsiveness
    • Bamboat, Z. M. et al. Human liver dendritic cells promote T cell hyporesponsiveness. J. Immunol. 182, 1901-1911 (2009).
    • (2009) J. Immunol. , vol.182 , pp. 1901-1911
    • Bamboat, Z.M.1
  • 22
    • 84933177312 scopus 로고    scopus 로고
    • Liver inflammation abrogates immunological tolerance induced by Kupffer cells
    • Heymann, F. et al. Liver inflammation abrogates immunological tolerance induced by Kupffer cells. Hepatology 62, 279-291 (2015).
    • (2015) Hepatology , vol.62 , pp. 279-291
    • Heymann, F.1
  • 23
    • 33644775720 scopus 로고    scopus 로고
    • CRIg: A macrophage complement receptor required for phagocytosis of circulating pathogens
    • Helmy, K. Y. et al. CRIg: a macrophage complement receptor required for phagocytosis of circulating pathogens. Cell 124, 915-927 (2006).
    • (2006) Cell , vol.124 , pp. 915-927
    • Helmy, K.Y.1
  • 24
    • 0028917669 scopus 로고
    • Human Kupffer cells secrete IL-10 in response to lipopolysaccharide (LPS) challenge
    • Knolle, P. et al. Human Kupffer cells secrete IL-10 in response to lipopolysaccharide (LPS) challenge. J. Hepatol. 22, 226-229 (1995).
    • (1995) J. Hepatol. , vol.22 , pp. 226-229
    • Knolle, P.1
  • 25
    • 84886646838 scopus 로고    scopus 로고
    • Immune surveillance by the liver
    • Jenne, C. N. & Kubes, P. Immune surveillance by the liver. Nat. Immunol. 14, 996-1006 (2013).
    • (2013) Nat. Immunol. , vol.14 , pp. 996-1006
    • Jenne, C.N.1    Kubes, P.2
  • 26
    • 33745616804 scopus 로고    scopus 로고
    • low/neg accessory cells with dendritic-cell features
    • low/neg accessory cells with dendritic-cell features. Blood 108, 218-227 (2006).
    • (2006) Blood , vol.108 , pp. 218-227
    • Rutella, S.1
  • 27
    • 17044383038 scopus 로고    scopus 로고
    • absent dendritic cells with tolerogenic potential
    • absent dendritic cells with tolerogenic potential. J. Immunol. 174, 4706-4717 (2005).
    • (2005) J. Immunol. , vol.174 , pp. 4706-4717
    • Li, G.1    Kim, Y.J.2    Broxmeyer, H.E.3
  • 28
    • 18944377211 scopus 로고    scopus 로고
    • Flt3 ligand treatment reverses endotoxin tolerance-related immunoparalysis
    • Wysocka, M., Montaner, L. J. & Karp, C. L. Flt3 ligand treatment reverses endotoxin tolerance-related immunoparalysis. J. Immunol. 174, 7398-7402 (2005).
    • (2005) J. Immunol. , vol.174 , pp. 7398-7402
    • Wysocka, M.1    Montaner, L.J.2    Karp, C.L.3
  • 29
    • 84930018853 scopus 로고    scopus 로고
    • Combination of granulocyte colony-stimulating factor and erythropoietin improves outcomes of patients with decompensated cirrhosis
    • Kedarisetty, C. K. et al. Combination of granulocyte colony-stimulating factor and erythropoietin improves outcomes of patients with decompensated cirrhosis. Gastroenterology 148, 1362-1370.e7 (2015).
    • (2015) Gastroenterology , vol.148 , pp. 1362-1362e7
    • Kedarisetty, C.K.1
  • 30
    • 0037136328 scopus 로고    scopus 로고
    • Tryptophan-derived catabolites are responsible for inhibition of T and natural killer cell proliferation induced by indoleamine 2, 3-dioxygenase
    • Frumento, G. et al. Tryptophan-derived catabolites are responsible for inhibition of T and natural killer cell proliferation induced by indoleamine 2, 3-dioxygenase. J. Exp. Med. 196, 459-468 (2002).
    • (2002) J. Exp. Med. , vol.196 , pp. 459-468
    • Frumento, G.1
  • 31
    • 70350433798 scopus 로고    scopus 로고
    • Interferon-γ-triggered indoleamine 2, 3-dioxygenase competence in human monocyte-derived dendritic cells induces regulatory activity in allogeneic T cells
    • Jurgens, B., Hainz, U., Fuchs, D., Felzmann, T. & Heitger, A. Interferon-γ-triggered indoleamine 2, 3-dioxygenase competence in human monocyte-derived dendritic cells induces regulatory activity in allogeneic T cells. Blood 114, 3235-3243 (2009).
    • (2009) Blood , vol.114 , pp. 3235-3243
    • Jurgens, B.1    Hainz, U.2    Fuchs, D.3    Felzmann, T.4    Heitger, A.5
  • 32
    • 5644280249 scopus 로고    scopus 로고
    • The composition of intrahepatic lymphocytes: Shaped by selective recruitment?
    • Klugewitz, K., Adams, D. H., Emoto, M., Eulenburg, K. & Hamann, A. The composition of intrahepatic lymphocytes: shaped by selective recruitment? Trends Immunol. 25, 590-594 (2004).
    • (2004) Trends Immunol. , vol.25 , pp. 590-594
    • Klugewitz, K.1    Adams, D.H.2    Emoto, M.3    Eulenburg, K.4    Hamann, A.5
  • 33
    • 84878938696 scopus 로고    scopus 로고
    • Frequency and phenotype of human circulating and intrahepatic natural killer cell subsets is differentially regulated according to stage of chronic liver disease
    • Zimmermann, H. W. et al. Frequency and phenotype of human circulating and intrahepatic natural killer cell subsets is differentially regulated according to stage of chronic liver disease. Digestion 88, 1-16 (2013).
    • (2013) Digestion , vol.88 , pp. 1-16
    • Zimmermann, H.W.1
  • 34
    • 38749146900 scopus 로고    scopus 로고
    • TLR-dependent cross talk between human Kupffer cells and NK cells
    • Tu, Z. et al. TLR-dependent cross talk between human Kupffer cells and NK cells. J. Exp. Med. 205, 233-244 (2008).
    • (2008) J. Exp. Med. , vol.205 , pp. 233-244
    • Tu, Z.1
  • 35
    • 84928825044 scopus 로고    scopus 로고
    • Re-examining the origin and function of liver-resident NK cells
    • Peng, H. & Tian, Z. Re-examining the origin and function of liver-resident NK cells. Trends Immunol. 36, 293-299 (2015).
    • (2015) Trends Immunol. , vol.36 , pp. 293-299
    • Peng, H.1    Tian, Z.2
  • 37
    • 84924529960 scopus 로고    scopus 로고
    • + NK cells
    • + NK cells. J. Immunol. 194, 2467-2471 (2015).
    • (2015) J. Immunol. , vol.194 , pp. 2467-2471
    • Marquardt, N.1
  • 38
    • 19344371631 scopus 로고    scopus 로고
    • + NKT cells patrolling liver sinusoids
    • + NKT cells patrolling liver sinusoids. PLoS Biol. 3, e113 (2005).
    • (2005) PLoS Biol. , vol.3 , pp. e113
    • Geissmann, F.1
  • 39
    • 84877794003 scopus 로고    scopus 로고
    • Chemokine receptor CXCR6-dependent hepatic NK T Cell accumulation promotes inflammation and liver fibrosis
    • Wehr, A. et al. Chemokine receptor CXCR6-dependent hepatic NK T Cell accumulation promotes inflammation and liver fibrosis. J. Immunol. 190, 5226-5236 (2013).
    • (2013) J. Immunol. , vol.190 , pp. 5226-5236
    • Wehr, A.1
  • 40
    • 0035422520 scopus 로고    scopus 로고
    • Activating immunity in the liver. I. Liver dendritic cells (but not hepatocytes) are potent activators of IFN-γ release by liver NKT cells
    • Trobonjaca, Z., Leithäuser, F., Möller, P., Schirmbeck, R. & Reimann, J. Activating immunity in the liver. I. Liver dendritic cells (but not hepatocytes) are potent activators of IFN-γ release by liver NKT cells. J. Immunol. 167, 1413-1422 (2001).
    • (2001) J. Immunol. , vol.167 , pp. 1413-1422
    • Trobonjaca, Z.1    Leithäuser, F.2    Möller, P.3    Schirmbeck, R.4    Reimann, J.5
  • 41
    • 12844285609 scopus 로고    scopus 로고
    • Glycolipid presentation to natural killer T cells differs in an organ-dependent fashion
    • Schmieg, J., Yang, G., Franck, R. W., Van Rooijen, N. & Tsuji, M. Glycolipid presentation to natural killer T cells differs in an organ-dependent fashion. Proc. Natl Acad. Sci. USA 102, 1127-1132 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 1127-1132
    • Schmieg, J.1    Yang, G.2    Franck, R.W.3    Van Rooijen, N.4    Tsuji, M.5
  • 42
    • 0042123683 scopus 로고    scopus 로고
    • NKT cells from normal and tumor-bearing human livers are phenotypically and functionally distinct from murine NKT cells
    • Kenna, T. et al. NKT cells from normal and tumor-bearing human livers are phenotypically and functionally distinct from murine NKT cells. J. Immunol. 171, 1775-1779 (2003).
    • (2003) J. Immunol. , vol.171 , pp. 1775-1779
    • Kenna, T.1
  • 43
    • 77954914800 scopus 로고    scopus 로고
    • Antimicrobial activity of mucosal-associated invariant T cells
    • Le Bourhis, L. et al. Antimicrobial activity of mucosal-associated invariant T cells. Nat. Immunol. 11, 701-708 (2010).
    • (2010) Nat. Immunol. , vol.11 , pp. 701-708
    • Le Bourhis, L.1
  • 44
    • 84875466830 scopus 로고    scopus 로고
    • IL-7 licenses activation of human liver intrasinusoidal mucosal-associated invariant T cells
    • Tang, X.-Z. et al. IL-7 licenses activation of human liver intrasinusoidal mucosal-associated invariant T cells. J. Immunol. 190, 3142-3152 (2013).
    • (2013) J. Immunol. , vol.190 , pp. 3142-3152
    • Tang, X.-Z.1
  • 45
    • 66149152203 scopus 로고    scopus 로고
    • Systemic antigen cross-presented by liver sinusoidal endothelial cells induces liver-specific CD8 T-cell retention and tolerization
    • von Oppen, N. et al. Systemic antigen cross-presented by liver sinusoidal endothelial cells induces liver-specific CD8 T-cell retention and tolerization. Hepatology 49, 1664-1672 (2009).
    • (2009) Hepatology , vol.49 , pp. 1664-1672
    • Von Oppen, N.1
  • 46
    • 84878937578 scopus 로고    scopus 로고
    • The regulation of T-cell recruitment to the human liver during acute liver failure
    • Tuncer, C., Oo, Y. H., Murphy, N., Adams, D. H. & Lalor, P. F. The regulation of T-cell recruitment to the human liver during acute liver failure. Liver Int. 33, 852-863 (2013).
    • (2013) Liver Int. , vol.33 , pp. 852-863
    • Tuncer, C.1    Oo, Y.H.2    Murphy, N.3    Adams, D.H.4    Lalor, P.F.5
  • 47
    • 0037270978 scopus 로고    scopus 로고
    • Hepatic T cells and liver tolerance
    • Crispe, I. N. Hepatic T cells and liver tolerance. Nat. Rev. Immunol. 3, 51-62 (2003).
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 51-62
    • Crispe, I.N.1
  • 48
    • 79959555074 scopus 로고    scopus 로고
    • Murine hepatic stellate cells veto CD8 T cell activation by a CD54-dependent mechanism
    • Schildberg, F. A. et al. Murine hepatic stellate cells veto CD8 T cell activation by a CD54-dependent mechanism. Hepatology 54, 262-272 (2011).
    • (2011) Hepatology , vol.54 , pp. 262-272
    • Schildberg, F.A.1
  • 49
    • 33846212347 scopus 로고    scopus 로고
    • Ito cells are liver-resident antigen-presenting cells for activating T cell responses
    • Winau, F. et al. Ito cells are liver-resident antigen-presenting cells for activating T cell responses. Immunity 26, 117-129 (2007).
    • (2007) Immunity , vol.26 , pp. 117-129
    • Winau, F.1
  • 50
    • 84924230659 scopus 로고    scopus 로고
    • Cellular and molecular functions of hepatic stellate cells in inflammatory responses and liver immunology
    • Weiskirchen, R. & Tacke, F. Cellular and molecular functions of hepatic stellate cells in inflammatory responses and liver immunology. Hepatobiliary Surg. Nutr. 3, 344-363 (2014).
    • (2014) Hepatobiliary Surg. Nutr. , vol.3 , pp. 344-363
    • Weiskirchen, R.1    Tacke, F.2
  • 51
    • 84879844767 scopus 로고    scopus 로고
    • Human hepatic stellate cells inhibit T-cell response through B7-H1 pathway
    • Charles, R. et al. Human hepatic stellate cells inhibit T-cell response through B7-H1 pathway. Transplantation 96, 17-24 (2013).
    • (2013) Transplantation , vol.96 , pp. 17-24
    • Charles, R.1
  • 52
    • 51349131121 scopus 로고    scopus 로고
    • Mechanism of T cell tolerance induction by murine hepatic Kupffer cells
    • You, Q., Cheng, L., Kedl, R. M. & Ju, C. Mechanism of T cell tolerance induction by murine hepatic Kupffer cells. Hepatology 48, 978 (2008).
    • (2008) Hepatology , vol.48 , pp. 978
    • You, Q.1    Cheng, L.2    Kedl, R.M.3    Ju, C.4
  • 53
    • 76549127740 scopus 로고    scopus 로고
    • Inhibition of allogeneic T-cell response by Kupffer cells expressing indoleamine 2, 3-dioxygenase
    • Yan, M. L., Wang, Y. D., Tian, Y. F., Lai, Z. D. & Yan, L. N. Inhibition of allogeneic T-cell response by Kupffer cells expressing indoleamine 2, 3-dioxygenase. World J. Gastroenterol. 16, 636-640 (2010).
    • (2010) World J. Gastroenterol. , vol.16 , pp. 636-640
    • Yan, M.L.1    Wang, Y.D.2    Tian, Y.F.3    Lai, Z.D.4    Yan, L.N.5
  • 54
    • 0033002962 scopus 로고    scopus 로고
    • + T cells by antigen-presenting murine liver sinusoidal endothelial cells but failure to induce differentiation toward Th1 cells
    • + T cells by antigen-presenting murine liver sinusoidal endothelial cells but failure to induce differentiation toward Th1 cells. Gastroenterology 116, 1428-1440 (1999).
    • (1999) Gastroenterology , vol.116 , pp. 1428-1440
    • Knolle, P.A.1
  • 55
    • 84871247127 scopus 로고    scopus 로고
    • Inhibition of inflammatory CD4 T cell activity by murine liver sinusoidal endothelial cells
    • Carambia, A. et al. Inhibition of inflammatory CD4 T cell activity by murine liver sinusoidal endothelial cells. J. Hepatol. 58, 112-118 (2013).
    • (2013) J. Hepatol. , vol.58 , pp. 112-118
    • Carambia, A.1
  • 56
    • 73149098744 scopus 로고    scopus 로고
    • - regulatory T cells suppressing autoimmune hepatitis
    • - regulatory T cells suppressing autoimmune hepatitis. Hepatology 50, 1904-1913 (2009).
    • (2009) Hepatology , vol.50 , pp. 1904-1913
    • Kruse, N.1
  • 57
    • 84874268340 scopus 로고    scopus 로고
    • + regulatory T cells by production of retinoic acid
    • + regulatory T cells by production of retinoic acid. J. Immunol. 190, 2009-2016 (2013).
    • (2013) J. Immunol. , vol.190 , pp. 2009-2016
    • Dunham, R.M.1
  • 58
    • 72549114816 scopus 로고    scopus 로고
    • PD-1/B7-H1 interaction contribute to the spontaneous acceptance of mouse liver allograft
    • Morita, M. et al. PD-1/B7-H1 interaction contribute to the spontaneous acceptance of mouse liver allograft. Am. J. Transplant. 10, 40-46 (2010).
    • (2010) Am. J. Transplant. , vol.10 , pp. 40-46
    • Morita, M.1
  • 59
    • 0034533209 scopus 로고    scopus 로고
    • + T cells results in antigen-specific T-cell tolerance
    • + T cells results in antigen-specific T-cell tolerance. Nat. Med. 6, 1348-1354 (2000).
    • (2000) Nat. Med. , vol.6 , pp. 1348-1354
    • Limmer, A.1
  • 60
    • 27644481817 scopus 로고    scopus 로고
    • Cross-presentation of oral antigens by liver sinusoidal endothelial cells leads to CD8 T cell tolerance
    • Limmer, A. et al. Cross-presentation of oral antigens by liver sinusoidal endothelial cells leads to CD8 T cell tolerance. Eur. J. Immunol. 35, 2970-2981 (2005).
    • (2005) Eur. J. Immunol. , vol.35 , pp. 2970-2981
    • Limmer, A.1
  • 61
    • 38649137987 scopus 로고    scopus 로고
    • + T cell tolerance
    • + T cell tolerance. Hepatology 47, 296-305 (2008).
    • (2008) Hepatology , vol.47 , pp. 296-305
    • Diehl, L.1
  • 62
    • 51449107778 scopus 로고    scopus 로고
    • Intrahepatic murine CD8 T-cell activation associates with a distinct phenotype leading to Bim-dependent death
    • Holz, L. E. et al. Intrahepatic murine CD8 T-cell activation associates with a distinct phenotype leading to Bim-dependent death. Gastroenterology 135, 989-997 (2008).
    • (2008) Gastroenterology , vol.135 , pp. 989-997
    • Holz, L.E.1
  • 63
    • 43049112084 scopus 로고    scopus 로고
    • Bim-mediated deletion of antigen-specific CD8 T cells in patients unable to control HBV infection
    • Lopes, A. R. et al. Bim-mediated deletion of antigen-specific CD8 T cells in patients unable to control HBV infection. J. Clin. Invest. 118, 1835-1845 (2008).
    • (2008) J. Clin. Invest. , vol.118 , pp. 1835-1845
    • Lopes, A.R.1
  • 64
    • 80053653657 scopus 로고    scopus 로고
    • Hepatocyte entry leads to degradation of autoreactive CD8 T cells
    • Benseler, V. et al. Hepatocyte entry leads to degradation of autoreactive CD8 T cells. Proc. Natl Acad. Sci. USA 108, 16735-16740 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 16735-16740
    • Benseler, V.1
  • 65
    • 84864748513 scopus 로고    scopus 로고
    • Alarmins: Awaiting a clinical response
    • Chan, J. K. et al. Alarmins: awaiting a clinical response. J. Clin. Invest. 122, 2711-2719 (2012).
    • (2012) J. Clin. Invest. , vol.122 , pp. 2711-2719
    • Chan, J.K.1
  • 66
    • 84865169674 scopus 로고    scopus 로고
    • IL-33 and HMGB1 alarmins: Sensors of cellular death and their involvement in liver pathology
    • Arshad, M. I., Piquet-Pellorce, C. & Samson, M. IL-33 and HMGB1 alarmins: sensors of cellular death and their involvement in liver pathology. Liver Int. 32, 1200-1210 (2012).
    • (2012) Liver Int. , vol.32 , pp. 1200-1210
    • Arshad, M.I.1    Piquet-Pellorce, C.2    Samson, M.3
  • 68
    • 78650793157 scopus 로고    scopus 로고
    • Bile acids induce inflammatory genes in hepatocytes: A novel mechanism of inflammation during obstructive cholestasis
    • Allen, K., Jaeschke, H. & Copple, B. L. Bile acids induce inflammatory genes in hepatocytes: a novel mechanism of inflammation during obstructive cholestasis. Am. J. Pathol. 178, 175-186 (2011).
    • (2011) Am. J. Pathol. , vol.178 , pp. 175-186
    • Allen, K.1    Jaeschke, H.2    Copple, B.L.3
  • 69
    • 84871330823 scopus 로고    scopus 로고
    • The cholesterol derivative 27-hydroxycholesterol reduces steatohepatitis in mice
    • Bieghs, V. et al. The cholesterol derivative 27-hydroxycholesterol reduces steatohepatitis in mice. Gastroenterology 144, 167-178.e1 (2013).
    • (2013) Gastroenterology , vol.144 , pp. 167-167e1
    • Bieghs, V.1
  • 70
    • 83755163159 scopus 로고    scopus 로고
    • A high-cholesterol diet exacerbates liver fibrosis in mice via accumulation of free cholesterol in hepatic stellate cells
    • Teratani, T. et al. A high-cholesterol diet exacerbates liver fibrosis in mice via accumulation of free cholesterol in hepatic stellate cells. Gastroenterology 142, 152-164.e10 (2012).
    • (2012) Gastroenterology , vol.142 , pp. 152-152e10
    • Teratani, T.1
  • 71
    • 34247236200 scopus 로고    scopus 로고
    • Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE
    • Tian, J. et al. Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE. Nat. Immunol. 8, 487-496 (2007).
    • (2007) Nat. Immunol. , vol.8 , pp. 487-496
    • Tian, J.1
  • 72
    • 84948614431 scopus 로고    scopus 로고
    • The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis
    • Huebener, P. et al. The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis. J. Clin. Invest. 125, 539-550 (2015).
    • (2015) J. Clin. Invest. , vol.125 , pp. 539-550
    • Huebener, P.1
  • 73
    • 20244373939 scopus 로고    scopus 로고
    • The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion
    • Tsung, A. et al. The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion. J. Exp. Med. 201, 1135-1143 (2005).
    • (2005) J. Exp. Med. , vol.201 , pp. 1135-1143
    • Tsung, A.1
  • 74
    • 84901013877 scopus 로고    scopus 로고
    • Structural biology of the IL-1 superfamily: Key cytokines in the regulation of immune and inflammatory responses
    • Krumm, B., Xiang, Y. & Deng, J. Structural biology of the IL-1 superfamily: key cytokines in the regulation of immune and inflammatory responses. Protein Sci. 23, 526-538 (2014).
    • (2014) Protein Sci. , vol.23 , pp. 526-538
    • Krumm, B.1    Xiang, Y.2    Deng, J.3
  • 75
    • 83555160892 scopus 로고    scopus 로고
    • Protective role of IL-33/ST2 axis in Con A-induced hepatitis
    • Volarevic, V. et al. Protective role of IL-33/ST2 axis in Con A-induced hepatitis. J. Hepatol. 56, 26-33 (2012).
    • (2012) J. Hepatol. , vol.56 , pp. 26-33
    • Volarevic, V.1
  • 76
    • 84882580383 scopus 로고    scopus 로고
    • Interleukin-33-dependent innate lymphoid cells mediate hepatic fibrosis
    • McHedlidze, T. et al. Interleukin-33-dependent innate lymphoid cells mediate hepatic fibrosis. Immunity 39, 357-371 (2013).
    • (2013) Immunity , vol.39 , pp. 357-371
    • McHedlidze, T.1
  • 77
    • 83555160887 scopus 로고    scopus 로고
    • IL-33 - A cytokine which balances on a knife's edge?
    • Erhardt, A. & Tiegs, G. IL-33 - A cytokine which balances on a knife's edge? J. Hepatol. 56, 7-10 (2012).
    • (2012) J. Hepatol. , vol.56 , pp. 7-10
    • Erhardt, A.1    Tiegs, G.2
  • 78
    • 84936891896 scopus 로고    scopus 로고
    • Inflammasomes: Mechanism of action, role in disease, and therapeutics
    • Guo, H., Callaway, J. B. & Ting, J. P. Inflammasomes: mechanism of action, role in disease, and therapeutics. Nat. Med. 21, 677-687 (2015).
    • (2015) Nat. Med. , vol.21 , pp. 677-687
    • Guo, H.1    Callaway, J.B.2    Ting, J.P.3
  • 79
  • 80
    • 84865504141 scopus 로고    scopus 로고
    • Sterile inflammation in the liver
    • Kubes, P. & Mehal, W. Z. Sterile inflammation in the liver. Gastroenterology 143, 1158-1172 (2012).
    • (2012) Gastroenterology , vol.143 , pp. 1158-1172
    • Kubes, P.1    Mehal, W.Z.2
  • 81
    • 0036671894 scopus 로고    scopus 로고
    • The inflammasome: A molecular platform triggering activation of inflammatory caspases and processing of proIL-β
    • Martinon, F., Burns, K. & Tschopp, J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-β. Mol. Cell 10, 417-426 (2002).
    • (2002) Mol. Cell , vol.10 , pp. 417-426
    • Martinon, F.1    Burns, K.2    Tschopp, J.3
  • 82
    • 79751512463 scopus 로고    scopus 로고
    • The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
    • Vandanmagsar, B. et al. The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat. Med. 17, 179-188 (2011).
    • (2011) Nat. Med. , vol.17 , pp. 179-188
    • Vandanmagsar, B.1
  • 83
    • 84879605752 scopus 로고    scopus 로고
    • ASC/caspase-1/IL-1β signaling triggers inflammatory responses by promoting HMGB1 induction in liver ischemia/reperfusion injury
    • Kamo, N. et al. ASC/caspase-1/IL-1β signaling triggers inflammatory responses by promoting HMGB1 induction in liver ischemia/reperfusion injury. Hepatology 58, 351-362 (2013).
    • (2013) Hepatology , vol.58 , pp. 351-362
    • Kamo, N.1
  • 84
    • 84883367417 scopus 로고    scopus 로고
    • Histones activate the NLRP3 inflammasome in Kupffer cells during sterile inflammatory liver injury
    • Huang, H. et al. Histones activate the NLRP3 inflammasome in Kupffer cells during sterile inflammatory liver injury. J. Immunol. 191, 2665-2679 (2013).
    • (2013) J. Immunol. , vol.191 , pp. 2665-2679
    • Huang, H.1
  • 85
    • 77957943307 scopus 로고    scopus 로고
    • Intravascular danger signals guide neutrophils to sites of sterile inflammation
    • McDonald, B. et al. Intravascular danger signals guide neutrophils to sites of sterile inflammation. Science 330, 362-366 (2010).
    • (2010) Science , vol.330 , pp. 362-366
    • McDonald, B.1
  • 86
    • 84875642466 scopus 로고    scopus 로고
    • Altered responsiveness to extracellular ATP enhances acetaminophen hepatotoxicity
    • Amaral, S. S. et al. Altered responsiveness to extracellular ATP enhances acetaminophen hepatotoxicity. Cell Commun. Signal. 11, 10 (2013).
    • (2013) Cell Commun. Signal. , vol.11 , pp. 10
    • Amaral, S.S.1
  • 87
    • 84896709837 scopus 로고    scopus 로고
    • NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice
    • Wree, A. et al. NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice. Hepatology 59, 898-910 (2014).
    • (2014) Hepatology , vol.59 , pp. 898-910
    • Wree, A.1
  • 88
    • 84925516213 scopus 로고    scopus 로고
    • Extracellular ATP induces P2X7 receptor activation in mouse Kupffer cells, leading to release of IL-1β, HMGB1, and PGE2, decreased MHC class i expression and necrotic cell death
    • Toki, Y. et al. Extracellular ATP induces P2X7 receptor activation in mouse Kupffer cells, leading to release of IL-1β, HMGB1, and PGE2, decreased MHC class I expression and necrotic cell death. Biochem. Biophys. Res. Commun. 458, 771-776 (2015).
    • (2015) Biochem. Biophys. Res. Commun. , vol.458 , pp. 771-776
    • Toki, Y.1
  • 89
    • 84901218517 scopus 로고    scopus 로고
    • Lactate reduces liver and pancreatic injury in Toll-like receptor-and inflammasome-mediated inflammation via GPR81-mediated suppression of innate immunity
    • Hoque, R., Farooq, A., Ghani, A., Gorelick, F. & Mehal, W. Z. Lactate reduces liver and pancreatic injury in Toll-like receptor-and inflammasome-mediated inflammation via GPR81-mediated suppression of innate immunity. Gastroenterology 146, 1763-1774 (2014).
    • (2014) Gastroenterology , vol.146 , pp. 1763-1774
    • Hoque, R.1    Farooq, A.2    Ghani, A.3    Gorelick, F.4    Mehal, W.Z.5
  • 90
    • 84870986481 scopus 로고    scopus 로고
    • Toll-like receptors in liver disease
    • Petrasek, J., Csak, T. & Szabo, G. Toll-like receptors in liver disease. Adv. Clin. Chem. 59, 155-201 (2013).
    • (2013) Adv. Clin. Chem. , vol.59 , pp. 155-201
    • Petrasek, J.1    Csak, T.2    Szabo, G.3
  • 91
    • 84907225684 scopus 로고    scopus 로고
    • Alterations of the human gut microbiome in liver cirrhosis
    • Qin, N. et al. Alterations of the human gut microbiome in liver cirrhosis. Nature 513, 59-64 (2014).
    • (2014) Nature , vol.513 , pp. 59-64
    • Qin, N.1
  • 92
    • 66349110620 scopus 로고    scopus 로고
    • Toll-like receptors as targets in chronic liver diseases
    • Mencin, A., Kluwe, J. & Schwabe, R. F. Toll-like receptors as targets in chronic liver diseases. Gut 58, 704 (2009).
    • (2009) Gut , vol.58 , pp. 704
    • Mencin, A.1    Kluwe, J.2    Schwabe, R.F.3
  • 93
    • 21344466070 scopus 로고    scopus 로고
    • + regulatory T cells
    • + regulatory T cells. Hepatology 42, 193-199 (2005).
    • (2005) Hepatology , vol.42 , pp. 193-199
    • Wiegard, C.1
  • 94
    • 0038185316 scopus 로고    scopus 로고
    • Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells
    • Paik, Y.-H. et al. Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells. Hepatology 37, 1043-1055 (2003).
    • (2003) Hepatology , vol.37 , pp. 1043-1055
    • Paik, Y.-H.1
  • 95
    • 22544478118 scopus 로고    scopus 로고
    • + T cell trapping in the liver
    • + T cell trapping in the liver. J. Immunol. 175, 1643-1650 (2005).
    • (2005) J. Immunol. , vol.175 , pp. 1643-1650
    • John, B.1    Crispe, I.N.2
  • 96
    • 84879605175 scopus 로고    scopus 로고
    • Cellular-specific role of toll-like receptor 4 in hepatic ischemia-reperfusion injury in mice
    • Nace, G. W. et al. Cellular-specific role of toll-like receptor 4 in hepatic ischemia-reperfusion injury in mice. Hepatology 58, 374-387 (2013).
    • (2013) Hepatology , vol.58 , pp. 374-387
    • Nace, G.W.1
  • 97
    • 34548272744 scopus 로고    scopus 로고
    • Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis
    • Rivera, C. A. et al. Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis. J. Hepatol. 47, 571-579 (2007).
    • (2007) J. Hepatol. , vol.47 , pp. 571-579
    • Rivera, C.A.1
  • 98
    • 79959811718 scopus 로고    scopus 로고
    • Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice
    • Inokuchi, S. et al. Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice. Alcohol. Clin. Exp. Res. 35, 1509-1518 (2011).
    • (2011) Alcohol. Clin. Exp. Res. , vol.35 , pp. 1509-1518
    • Inokuchi, S.1
  • 99
    • 84891837187 scopus 로고    scopus 로고
    • Toll-like receptors and liver disease
    • Kesar, V. & Odin, J. A. Toll-like receptors and liver disease. Liver Int. 34, 184-196 (2014).
    • (2014) Liver Int. , vol.34 , pp. 184-196
    • Kesar, V.1    Odin, J.A.2
  • 101
    • 84878276077 scopus 로고    scopus 로고
    • GS-9620, an oral agonist of Tolllike receptor-7, induces prolonged suppression of hepatitis B virus in chronically infected chimpanzees
    • Lanford, R. E. et al. GS-9620, an oral agonist of Tolllike receptor-7, induces prolonged suppression of hepatitis B virus in chronically infected chimpanzees. Gastroenterology 144, 1508-1517.e10 (2013).
    • (2013) Gastroenterology , vol.144 , pp. 1508-1508e10
    • Lanford, R.E.1
  • 102
    • 84956808985 scopus 로고    scopus 로고
    • US National Library of Science. Safety and efficacy of GS-9620 for the treatment of chronic hepatitis B virus in virally-suppressed subjects. ClinicalTrials.gov [online]
    • US National Library of Science. Safety and efficacy of GS-9620 for the treatment of chronic hepatitis B virus in virally-suppressed subjects. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT02166047 (2014).
    • (2014)
  • 103
    • 61749099391 scopus 로고    scopus 로고
    • Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome
    • Imaeda, A. B. et al. Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome. J. Clin. Invest. 119, 305-314 (2009).
    • (2009) J. Clin. Invest. , vol.119 , pp. 305-314
    • Imaeda, A.B.1
  • 104
    • 76649117721 scopus 로고    scopus 로고
    • Conventional DCs reduce liver ischemia/reperfusion injury in mice via IL-10 secretion
    • Bamboat, Z. M. et al. Conventional DCs reduce liver ischemia/reperfusion injury in mice via IL-10 secretion. J. Clin. Invest. 120, 559-569 (2010).
    • (2010) J. Clin. Invest. , vol.120 , pp. 559-569
    • Bamboat, Z.M.1
  • 105
    • 73149110853 scopus 로고    scopus 로고
    • Activation of the complement system in human nonalcoholic fatty liver disease
    • Rensen, S. S. et al. Activation of the complement system in human nonalcoholic fatty liver disease. Hepatology 50, 1809-1817 (2009).
    • (2009) Hepatology , vol.50 , pp. 1809-1817
    • Rensen, S.S.1
  • 106
    • 84907833288 scopus 로고    scopus 로고
    • Complement alternative pathway activation in human nonalcoholic steatohepatitis
    • Segers, F. M. et al. Complement alternative pathway activation in human nonalcoholic steatohepatitis. PLoS ONE 9, e110053 (2014).
    • (2014) PLoS ONE , vol.9 , pp. e110053
    • Segers, F.M.1
  • 107
    • 84907522167 scopus 로고    scopus 로고
    • Increased activity of the complement system in the liver of patients with alcoholic hepatitis
    • Shen, H., French, B. A., Liu, H., Tillman, B. C. & French, S. W. Increased activity of the complement system in the liver of patients with alcoholic hepatitis. Exp. Mol. Pathol. 97, 338-344 (2014).
    • (2014) Exp. Mol. Pathol. , vol.97 , pp. 338-344
    • Shen, H.1    French, B.A.2    Liu, H.3    Tillman, B.C.4    French, S.W.5
  • 108
    • 33947320624 scopus 로고    scopus 로고
    • Differential contributions of C3, C5, and decay-accelerating factor to ethanol-induced fatty liver in mice
    • Pritchard, M. T. et al. Differential contributions of C3, C5, and decay-accelerating factor to ethanol-induced fatty liver in mice. Gastroenterology 132, 1117-1126 (2007).
    • (2007) Gastroenterology , vol.132 , pp. 1117-1126
    • Pritchard, M.T.1
  • 109
    • 33744998117 scopus 로고    scopus 로고
    • Complement C3 contributes to ethanol-induced liver steatosis in mice
    • Bykov, I., Junnikkala, S., Pekna, M., Lindros, K. O. & Meri, S. Complement C3 contributes to ethanol-induced liver steatosis in mice. Ann. Med. 38, 280-286 (2006).
    • (2006) Ann. Med. , vol.38 , pp. 280-286
    • Bykov, I.1    Junnikkala, S.2    Pekna, M.3    Lindros, K.O.4    Meri, S.5
  • 110
    • 77955474503 scopus 로고    scopus 로고
    • Complement and alcoholic liver disease: Role of C1q in the pathogenesis of ethanol-induced liver injury in mice
    • Cohen, J. I., Roychowdhury, S., McMullen, M. R., Stavitsky, A. B. & Nagy, L. E. Complement and alcoholic liver disease: role of C1q in the pathogenesis of ethanol-induced liver injury in mice. Gastroenterology 139, 664-674.e1 (2010).
    • (2010) Gastroenterology , vol.139 , pp. 664-664e1
    • Cohen, J.I.1    Roychowdhury, S.2    McMullen, M.R.3    Stavitsky, A.B.4    Nagy, L.E.5
  • 111
    • 84899789058 scopus 로고    scopus 로고
    • The role of neutrophils in the development of liver diseases
    • Xu, R., Huang, H., Zhang, Z. & Wang, F. S. The role of neutrophils in the development of liver diseases. Cell. Mol. Immunol. 11, 224-231 (2014).
    • (2014) Cell. Mol. Immunol. , vol.11 , pp. 224-231
    • Xu, R.1    Huang, H.2    Zhang, Z.3    Wang, F.S.4
  • 112
    • 51349126118 scopus 로고    scopus 로고
    • Physiology and pathophysiology of liver inflammation, damage and repair
    • Ramadori, G., Moriconi, F., Malik, I. & Dudas, J. Physiology and pathophysiology of liver inflammation, damage and repair. J. Physiol. Pharmacol. 59, S107-S117 (2008).
    • (2008) J. Physiol. Pharmacol. , vol.59 , pp. S107-S117
    • Ramadori, G.1    Moriconi, F.2    Malik, I.3    Dudas, J.4
  • 113
    • 84906535982 scopus 로고    scopus 로고
    • Roles for chemokines in liver disease
    • Marra, F. & Tacke, F. Roles for chemokines in liver disease. Gastroenterology 147, 577-594.e1 (2014).
    • (2014) Gastroenterology , vol.147 , pp. 577-577e1
    • Marra, F.1    Tacke, F.2
  • 114
    • 84896405331 scopus 로고    scopus 로고
    • A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse
    • Moles, A. et al. A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse. J. Hepatol. 60, 782 (2014).
    • (2014) J. Hepatol. , vol.60 , pp. 782
    • Moles, A.1
  • 115
    • 84868203266 scopus 로고    scopus 로고
    • Chemokines and mitochondrial products activate neutrophils to amplify organ injury during mouse acute liver failure
    • Marques, P. E. et al. Chemokines and mitochondrial products activate neutrophils to amplify organ injury during mouse acute liver failure. Hepatology 56, 1971-1982 (2012).
    • (2012) Hepatology , vol.56 , pp. 1971-1982
    • Marques, P.E.1
  • 116
    • 84925763736 scopus 로고    scopus 로고
    • Molecular mechanisms of NET formation and degradation revealed by intravital imaging in the liver vasculature
    • Kolaczkowska, E. et al. Molecular mechanisms of NET formation and degradation revealed by intravital imaging in the liver vasculature. Nat. Commun. 6, 6673 (2015).
    • (2015) Nat. Commun. , vol.6 , pp. 6673
    • Kolaczkowska, E.1
  • 117
    • 84866386143 scopus 로고    scopus 로고
    • Intravascular neutrophil extracellular traps capture bacteria from the bloodstream during sepsis
    • McDonald, B., Urrutia, R., Yipp, B. G., Jenne, C. N. & Kubes, P. Intravascular neutrophil extracellular traps capture bacteria from the bloodstream during sepsis. Cell Host Microbe 12, 324-333 (2012).
    • (2012) Cell Host Microbe , vol.12 , pp. 324-333
    • McDonald, B.1    Urrutia, R.2    Yipp, B.G.3    Jenne, C.N.4    Kubes, P.5
  • 118
    • 84873918079 scopus 로고    scopus 로고
    • Neutrophils recruited to sites of infection protect from virus challenge by releasing neutrophil extracellular traps
    • Jenne, C. N. et al. Neutrophils recruited to sites of infection protect from virus challenge by releasing neutrophil extracellular traps. Cell Host Microbe 13, 169-180 (2013).
    • (2013) Cell Host Microbe , vol.13 , pp. 169-180
    • Jenne, C.N.1
  • 119
    • 0025687478 scopus 로고
    • Neutrophils contribute to ischemia/reperfusion injury in rat liver in vivo
    • Jaeschke, H., Farhood, A. & Smith, C. W. Neutrophils contribute to ischemia/reperfusion injury in rat liver in vivo. FASEB J. 4, 3355-3359 (1990).
    • (1990) FASEB J. , vol.4 , pp. 3355-3359
    • Jaeschke, H.1    Farhood, A.2    Smith, C.W.3
  • 120
    • 0028912405 scopus 로고
    • Intercellular adhesion molecule 1 (ICAM-1) expression and its role in neutrophil-induced ischemia-reperfusion injury in rat liver
    • Farhood, A. et al. Intercellular adhesion molecule 1 (ICAM-1) expression and its role in neutrophil-induced ischemia-reperfusion injury in rat liver. J. Leukoc. Biol. 57, 368-374 (1995).
    • (1995) J. Leukoc. Biol. , vol.57 , pp. 368-374
    • Farhood, A.1
  • 121
    • 84874601937 scopus 로고    scopus 로고
    • Intravital imaging of neutrophil recruitment in hepatic ischemia-reperfusion injury in mice
    • Honda, M. et al. Intravital imaging of neutrophil recruitment in hepatic ischemia-reperfusion injury in mice. Transplantation 95, 551-558 (2013).
    • (2013) Transplantation , vol.95 , pp. 551-558
    • Honda, M.1
  • 122
    • 0036017174 scopus 로고    scopus 로고
    • Neutrophil-mediated tissue injury in alcoholic hepatitis
    • Jaeschke, H. Neutrophil-mediated tissue injury in alcoholic hepatitis. Alcohol 27, 23-27 (2002).
    • (2002) Alcohol , vol.27 , pp. 23-27
    • Jaeschke, H.1
  • 123
    • 84899560268 scopus 로고    scopus 로고
    • Metabolically induced liver inflammation leads to NASH and differs from LPS-or IL-1β-induced chronic inflammation
    • Liang, W. et al. Metabolically induced liver inflammation leads to NASH and differs from LPS-or IL-1β-induced chronic inflammation. Lab. Invest. 94, 491-502 (2014).
    • (2014) Lab. Invest. , vol.94 , pp. 491-502
    • Liang, W.1
  • 124
    • 84886689508 scopus 로고    scopus 로고
    • IL-17A synergistically enhances bile acid-induced inflammation during obstructive cholestasis
    • O'Brien, K. M. et al. IL-17A synergistically enhances bile acid-induced inflammation during obstructive cholestasis. Am. J. Pathol. 183, 1498-1507 (2013).
    • (2013) Am. J. Pathol. , vol.183 , pp. 1498-1507
    • O'Brien, K.M.1
  • 126
    • 84920724791 scopus 로고    scopus 로고
    • Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment
    • Lavin, Y. et al. Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment. Cell 159, 1312-1326 (2014).
    • (2014) Cell , vol.159 , pp. 1312-1326
    • Lavin, Y.1
  • 127
    • 56749174940 scopus 로고    scopus 로고
    • Exploring the full spectrum of macrophage activation
    • Mosser, D. M. & Edwards, J. P. Exploring the full spectrum of macrophage activation. Nat. Rev. Immunol. 8, 958-969 (2008).
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 958-969
    • Mosser, D.M.1    Edwards, J.P.2
  • 128
    • 80052650727 scopus 로고    scopus 로고
    • Cutting edge: Immunological consequences and trafficking of human regulatory macrophages administered to renal transplant recipients
    • Hutchinson, J. A. et al. Cutting edge: Immunological consequences and trafficking of human regulatory macrophages administered to renal transplant recipients. J. Immunol. 187, 2072-2078 (2011).
    • (2011) J. Immunol. , vol.187 , pp. 2072-2078
    • Hutchinson, J.A.1
  • 129
    • 84894102230 scopus 로고    scopus 로고
    • Transcriptome-based network analysis reveals a spectrum model of human macrophage activation
    • Xue, J. et al. Transcriptome-based network analysis reveals a spectrum model of human macrophage activation. Immunity 40, 274-288 (2014).
    • (2014) Immunity , vol.40 , pp. 274-288
    • Xue, J.1
  • 130
    • 84904394690 scopus 로고    scopus 로고
    • Macrophage activation and polarization: Nomenclature and experimental guidelines
    • Murray, P. J. et al. Macrophage activation and polarization: nomenclature and experimental guidelines. Immunity 41, 14-20 (2014).
    • (2014) Immunity , vol.41 , pp. 14-20
    • Murray, P.J.1
  • 131
    • 84869208905 scopus 로고    scopus 로고
    • Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis
    • Ramachandran, P. et al. Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis. Proc. Natl Acad. Sci. USA 109, E3186-E3195 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. E3186-E3195
    • Ramachandran, P.1
  • 132
    • 67651174837 scopus 로고    scopus 로고
    • + monocyte subset upon liver injury promotes hepatic fibrosis
    • + monocyte subset upon liver injury promotes hepatic fibrosis. Hepatology 50, 261-274 (2009).
    • (2009) Hepatology , vol.50 , pp. 261-274
    • Karlmark, K.R.1
  • 133
    • 84928254123 scopus 로고    scopus 로고
    • + monocytes at a site of sterile injury
    • + monocytes at a site of sterile injury. J. Exp. Med. 212, 447-456 (2015).
    • (2015) J. Exp. Med. , vol.212 , pp. 447-456
    • Dal-Secco, D.1
  • 134
    • 84903625203 scopus 로고    scopus 로고
    • Infiltrating monocyte-derived macrophages and resident kupffer cells display different ontogeny and functions in acute liver injury
    • Zigmond, E. et al. Infiltrating monocyte-derived macrophages and resident kupffer cells display different ontogeny and functions in acute liver injury. J. Immunol. 193, 344-353 (2014).
    • (2014) J. Immunol. , vol.193 , pp. 344-353
    • Zigmond, E.1
  • 135
    • 84871156049 scopus 로고    scopus 로고
    • Role of galectin-3 in classical and alternative macrophage activation in the liver following acetaminophen intoxication
    • Dragomir, A.-C. D., Sun, R., Choi, H., Laskin, J. D. & Laskin, D. L. Role of galectin-3 in classical and alternative macrophage activation in the liver following acetaminophen intoxication. J. Immunol. 189, 5934-5941 (2012).
    • (2012) J. Immunol. , vol.189 , pp. 5934-5941
    • Dragomir, A.-C.D.1    Sun, R.2    Choi, H.3    Laskin, J.D.4    Laskin, D.L.5
  • 136
    • 84929274273 scopus 로고    scopus 로고
    • Immune mechanisms in acetaminophen-induced acute liver failure
    • Krenkel, O., Mossanen, J. C. & Tacke, F. Immune mechanisms in acetaminophen-induced acute liver failure. Hepatobiliary Surg. Nutr. 3, 331-343 (2014).
    • (2014) Hepatobiliary Surg. Nutr. , vol.3 , pp. 331-343
    • Krenkel, O.1    Mossanen, J.C.2    Tacke, F.3
  • 137
    • 0036913249 scopus 로고    scopus 로고
    • Protective role of Kupffer cells in acetaminophen-induced hepatic injury in mice
    • Ju, C. et al. Protective role of Kupffer cells in acetaminophen-induced hepatic injury in mice. Chem. Res. Toxicol. 15, 1504-1513 (2002).
    • (2002) Chem. Res. Toxicol. , vol.15 , pp. 1504-1513
    • Ju, C.1
  • 138
    • 84952928093 scopus 로고    scopus 로고
    • CSF1 restores innate immunity following liver injury in mice and serum levels indicate outcomes of patients with acute liver failure
    • Stutchfield, B. M. et al. CSF1 restores innate immunity following liver injury in mice and serum levels indicate outcomes of patients with acute liver failure. Gastroenterology http://dx.doi.org/10.1053/j.gastro.2015.08.053 (2015).
    • (2015) Gastroenterology
    • Stutchfield, B.M.1
  • 139
    • 0037686692 scopus 로고    scopus 로고
    • Hepatic allograft-derived Kupffer cells regulate T cell response in rats
    • Sun, Z. et al. Hepatic allograft-derived Kupffer cells regulate T cell response in rats. Liver Transpl. 9, 489-497 (2003).
    • (2003) Liver Transpl. , vol.9 , pp. 489-497
    • Sun, Z.1
  • 140
    • 78649464770 scopus 로고    scopus 로고
    • Kupffer cells promote acute rejection via induction of Th17 differentiation in rat liver allografts
    • Xie, X. et al. Kupffer cells promote acute rejection via induction of Th17 differentiation in rat liver allografts. Transplant. Proc. 42, 3784-3792 (2010).
    • (2010) Transplant. Proc. , vol.42 , pp. 3784-3792
    • Xie, X.1
  • 141
    • 84924993872 scopus 로고    scopus 로고
    • Activation of NLRP3 and AIM2 inflammasomes in Kupffer cells in hepatic ischemia/reperfusion
    • Kim, H. Y., Kim, S. J. & Lee, S. M. Activation of NLRP3 and AIM2 inflammasomes in Kupffer cells in hepatic ischemia/reperfusion. FEBS J. 282, 259-270 (2015).
    • (2015) FEBS J. , vol.282 , pp. 259-270
    • Kim, H.Y.1    Kim, S.J.2    Lee, S.M.3
  • 142
    • 84926323336 scopus 로고    scopus 로고
    • VEGFR1-positive macrophages facilitate liver repair and sinusoidal reconstruction after hepatic ischemia/reperfusion injury
    • Ohkubo, H. et al. VEGFR1-positive macrophages facilitate liver repair and sinusoidal reconstruction after hepatic ischemia/reperfusion injury. PLoS ONE 9, e105533 (2014).
    • (2014) PLoS ONE , vol.9 , pp. e105533
    • Ohkubo, H.1
  • 143
    • 77954693077 scopus 로고    scopus 로고
    • Murine Kupffer cells are protective in total hepatic ischemia/reperfusion injury with bowel congestion through IL-10
    • Ellett, J. D. et al. Murine Kupffer cells are protective in total hepatic ischemia/reperfusion injury with bowel congestion through IL-10. J. Immunol. 184, 5849-5858 (2010).
    • (2010) J. Immunol. , vol.184 , pp. 5849-5858
    • Ellett, J.D.1
  • 144
    • 84904392112 scopus 로고    scopus 로고
    • Macrophages immunity, and metabolic disease
    • McNelis, J. C. & Olefsky, J. M. Macrophages, immunity, and metabolic disease. Immunity 41, 36-48 (2014).
    • (2014) Immunity , vol.41 , pp. 36-48
    • McNelis, J.C.1    Olefsky, J.M.2
  • 145
    • 84894798789 scopus 로고    scopus 로고
    • M2 Kupffer cells promote M1 Kupffer cell apoptosis: A protective mechanism against alcoholic and nonalcoholic fatty liver disease
    • Wan, J. et al. M2 Kupffer cells promote M1 Kupffer cell apoptosis: a protective mechanism against alcoholic and nonalcoholic fatty liver disease. Hepatology 59, 130-142 (2014).
    • (2014) Hepatology , vol.59 , pp. 130-142
    • Wan, J.1
  • 146
    • 33144463511 scopus 로고    scopus 로고
    • Tumour necrosis factor α signalling through activation of Kupffer cells plays an essential role in liver fibrosis of non-alcoholic steatohepatitis in mice
    • Tomita, K. et al. Tumour necrosis factor α signalling through activation of Kupffer cells plays an essential role in liver fibrosis of non-alcoholic steatohepatitis in mice. Gut 55, 415 (2006).
    • (2006) Gut , vol.55 , pp. 415
    • Tomita, K.1
  • 147
    • 84862669638 scopus 로고    scopus 로고
    • Toxic lipids stored by Kupffer cells correlates with their pro-inflammatory phenotype at an early stage of steatohepatitis
    • Leroux, A. et al. Toxic lipids stored by Kupffer cells correlates with their pro-inflammatory phenotype at an early stage of steatohepatitis. J. Hepatol. 57, 141-149 (2012).
    • (2012) J. Hepatol. , vol.57 , pp. 141-149
    • Leroux, A.1
  • 148
    • 84908238878 scopus 로고    scopus 로고
    • Both bone marrow-derived and non-bone marrow-derived cells contribute to AIM2 and NLRP3 inflammasome activation in a MyD88-dependent manner in dietary steatohepatitis
    • Csak, T. et al. Both bone marrow-derived and non-bone marrow-derived cells contribute to AIM2 and NLRP3 inflammasome activation in a MyD88-dependent manner in dietary steatohepatitis. Liver Int. 34, 1402-1413 (2014).
    • (2014) Liver Int. , vol.34 , pp. 1402-1413
    • Csak, T.1
  • 149
    • 77953891627 scopus 로고    scopus 로고
    • Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1β in mice
    • Miura, K. et al. Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1β in mice. Gastroenterology 139, 323-334.e7 (2010).
    • (2010) Gastroenterology , vol.139 , pp. 323-323e7
    • Miura, K.1
  • 151
    • 84857055199 scopus 로고    scopus 로고
    • Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury
    • Baeck, C. et al. Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury. Gut 61, 416-426 (2012).
    • (2012) Gut , vol.61 , pp. 416-426
    • Baeck, C.1
  • 152
    • 84906314467 scopus 로고    scopus 로고
    • The role of Kupffer cells in hepatitis B and hepatitis C virus infections
    • Boltjes, A., Movita, D., Boonstra, A. & Woltman, A. M. The role of Kupffer cells in hepatitis B and hepatitis C virus infections. J. Hepatol. 61, 660-671 (2014).
    • (2014) J. Hepatol. , vol.61 , pp. 660-671
    • Boltjes, A.1    Movita, D.2    Boonstra, A.3    Woltman, A.M.4
  • 153
    • 84928563808 scopus 로고    scopus 로고
    • Inflammatory monocytes recruited to the liver within 24 hours after virus-induced inflammation resemble Kupffer cells but are functionally distinct
    • Movita, D. et al. Inflammatory monocytes recruited to the liver within 24 hours after virus-induced inflammation resemble Kupffer cells but are functionally distinct. J. Virol. 89, 4809-4817 (2015).
    • (2015) J. Virol. , vol.89 , pp. 4809-4817
    • Movita, D.1
  • 154
    • 84883533046 scopus 로고    scopus 로고
    • Mobilizing monocytes to cross-present circulating viral antigen in chronic infection
    • Gehring, A. J. et al. Mobilizing monocytes to cross-present circulating viral antigen in chronic infection. J. Clin. Invest. 123, 3766-3776 (2013).
    • (2013) J. Clin. Invest. , vol.123 , pp. 3766-3776
    • Gehring, A.J.1
  • 155
    • 84878233150 scopus 로고    scopus 로고
    • + T cells and successful immunotherapy against chronic viral liver infection
    • + T cells and successful immunotherapy against chronic viral liver infection. Nat. Immunol. 14, 574-583 (2013).
    • (2013) Nat. Immunol. , vol.14 , pp. 574-583
    • Huang, L.R.1
  • 156
    • 72549097659 scopus 로고    scopus 로고
    • Hepatitis C virus core protein subverts the antiviral activities of human Kupffer cells
    • Tu, Z. et al. Hepatitis C virus core protein subverts the antiviral activities of human Kupffer cells. Gastroenterology 138, 305-314 (2010).
    • (2010) Gastroenterology , vol.138 , pp. 305-314
    • Tu, Z.1
  • 157
    • 84896494832 scopus 로고    scopus 로고
    • Activated macrophages promote hepatitis C virus entry in a tumor necrosis factor-dependent manner
    • Fletcher, N. F. et al. Activated macrophages promote hepatitis C virus entry in a tumor necrosis factor-dependent manner. Hepatology 59, 1320-1330 (2014).
    • (2014) Hepatology , vol.59 , pp. 1320-1330
    • Fletcher, N.F.1
  • 158
    • 84876871333 scopus 로고    scopus 로고
    • IL-1 (3 production through the NLRP3 inflammasome by hepatic macrophages links hepatitis C virus infection with liver inflammation and disease
    • Negash, A. A. et al. IL-1 (3 production through the NLRP3 inflammasome by hepatic macrophages links hepatitis C virus infection with liver inflammation and disease. PLoS Pathog. 9, e1003330 (2013).
    • (2013) PLoS Pathog. , vol.9 , pp. e1003330
    • Negash, A.A.1
  • 159
    • 84930651350 scopus 로고    scopus 로고
    • Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells
    • Pallett, L. J. et al. Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells. Nat. Med. 21, 591-600 (2015).
    • (2015) Nat. Med. , vol.21 , pp. 591-600
    • Pallett, L.J.1
  • 160
    • 84970918672 scopus 로고    scopus 로고
    • Emerging roles of myeloid derived suppressor cells in hepatic inflammation and fibrosis
    • Hammerich, L. & Tacke, F Emerging roles of myeloid derived suppressor cells in hepatic inflammation and fibrosis. World J. Gastrointest. Pathophysiol. 6, 43-50 (2015).
    • (2015) World J. Gastrointest. Pathophysiol. , vol.6 , pp. 43-50
    • Hammerich, L.1    Tacke, F.2
  • 161
    • 84923408433 scopus 로고    scopus 로고
    • Cyclic adenosine monophosphate-responsive element modulator alpha overexpression impairs function of hepatic myeloid-derived suppressor cells and aggravates immune-mediated hepatitis in mice
    • Hammerich, L. et al. Cyclic adenosine monophosphate-responsive element modulator alpha overexpression impairs function of hepatic myeloid-derived suppressor cells and aggravates immune-mediated hepatitis in mice. Hepatology 61, 990-1002 (2015).
    • (2015) Hepatology , vol.61 , pp. 990-1002
    • Hammerich, L.1
  • 162
    • 84918555897 scopus 로고    scopus 로고
    • Myeloid-derived suppressor activity is mediated by monocytic lineages maintained by continuous inhibition of extrinsic and intrinsic death pathways
    • Haverkamp, J. M. et al. Myeloid-derived suppressor activity is mediated by monocytic lineages maintained by continuous inhibition of extrinsic and intrinsic death pathways. Immunity 41, 947-959 (2014).
    • (2014) Immunity , vol.41 , pp. 947-959
    • Haverkamp, J.M.1
  • 163
    • 79959382649 scopus 로고    scopus 로고
    • Interleukin-8 is activated in patients with chronic liver diseases and associated with hepatic macrophage accumulation in human liver fibrosis
    • Zimmermann, H. W. et al. Interleukin-8 is activated in patients with chronic liver diseases and associated with hepatic macrophage accumulation in human liver fibrosis. PLoS ONE 6, e21381 (2011).
    • (2011) PLoS ONE , vol.6 , pp. e21381
    • Zimmermann, H.W.1
  • 164
    • 84872159959 scopus 로고    scopus 로고
    • Monocyte subsets in human liver disease show distinct phenotypic and functional characteristics
    • Liaskou, E. et al. Monocyte subsets in human liver disease show distinct phenotypic and functional characteristics. Hepatology 57, 385-398 (2013).
    • (2013) Hepatology , vol.57 , pp. 385-398
    • Liaskou, E.1
  • 165
    • 77952739598 scopus 로고    scopus 로고
    • + monocytes across human liver sinusoidal endothelium
    • + monocytes across human liver sinusoidal endothelium. Hepatology 51, 2030-2039 (2010).
    • (2010) Hepatology , vol.51 , pp. 2030-2039
    • Aspinall, A.I.1
  • 166
    • 77955096540 scopus 로고    scopus 로고
    • Functional contribution of elevated circulating and hepatic non-classical CD14CD16 monocytes to inflammation and human liver fibrosis
    • Zimmermann, H. W. et al. Functional contribution of elevated circulating and hepatic non-classical CD14CD16 monocytes to inflammation and human liver fibrosis. PLoS ONE 5, e11049 (2010).
    • (2010) PLoS ONE , vol.5 , pp. e11049
    • Zimmermann, H.W.1
  • 167
    • 84923917947 scopus 로고    scopus 로고
    • Patients with acute-on-chronic liver failure have increased numbers of regulatory immune cells expressing the receptor tyrosine kinase MERTK
    • Bernsmeier, C. et al. Patients with acute-on-chronic liver failure have increased numbers of regulatory immune cells expressing the receptor tyrosine kinase MERTK. Gastroenterology 148, 603-615.e14 (2015).
    • (2015) Gastroenterology , vol.148 , pp. 603-603e14
    • Bernsmeier, C.1
  • 168
    • 84884984479 scopus 로고    scopus 로고
    • Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice
    • Pradere, J.-P. et al. Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice. Hepatology 58, 1461-1473 (2013).
    • (2013) Hepatology , vol.58 , pp. 1461-1473
    • Pradere, J.-P.1
  • 169
    • 84894072682 scopus 로고    scopus 로고
    • CCL2-dependent infiltrating macrophages promote angiogenesis in progressive liver fibrosis
    • Ehling, J. et al. CCL2-dependent infiltrating macrophages promote angiogenesis in progressive liver fibrosis. Gut 63, 1960-1971 (2014).
    • (2014) Gut , vol.63 , pp. 1960-1971
    • Ehling, J.1
  • 170
    • 84857444883 scopus 로고    scopus 로고
    • Hepatic macrophage migration and differentiation critical for liver fibrosis is mediated by the chemokine receptor C-C motif chemokine receptor 8 in mice
    • Heymann, F et al. Hepatic macrophage migration and differentiation critical for liver fibrosis is mediated by the chemokine receptor C-C motif chemokine receptor 8 in mice. Hepatology 55, 898-909 (2012).
    • (2012) Hepatology , vol.55 , pp. 898-909
    • Heymann, F.1
  • 171
    • 78049492110 scopus 로고    scopus 로고
    • 3CR1 protects against liver fibrosis by controlling differentiation and survival of infiltrating hepatic monocytes
    • 3CR1 protects against liver fibrosis by controlling differentiation and survival of infiltrating hepatic monocytes. Hepatology 52, 1769-1782 (2010).
    • (2010) Hepatology , vol.52 , pp. 1769-1782
    • Karlmark, K.R.1
  • 172
    • 79953656140 scopus 로고    scopus 로고
    • Association of T-zone reticular networks and conduits with ectopic lymphoid tissues in mice and humans
    • Link, A. et al. Association of T-zone reticular networks and conduits with ectopic lymphoid tissues in mice and humans. Am. J. Pathol. 178, 1662-1675 (2011).
    • (2011) Am. J. Pathol. , vol.178 , pp. 1662-1675
    • Link, A.1
  • 173
    • 33845869847 scopus 로고    scopus 로고
    • Increasing numbers of hepatic dendritic cells promote HMGB1-mediated ischemia-reperfusion injury
    • Tsung, A. et al. Increasing numbers of hepatic dendritic cells promote HMGB1-mediated ischemia-reperfusion injury. J. Leukoc. Biol. 81, 119-128 (2007).
    • (2007) J. Leukoc. Biol. , vol.81 , pp. 119-128
    • Tsung, A.1
  • 174
    • 84881028719 scopus 로고    scopus 로고
    • Dendritic cells limit fibroinflammatory injury in nonalcoholic steatohepatitis in mice
    • Henning, J. R. et al. Dendritic cells limit fibroinflammatory injury in nonalcoholic steatohepatitis in mice. Hepatology 58, 589-602 (2013).
    • (2013) Hepatology , vol.58 , pp. 589-602
    • Henning, J.R.1
  • 175
    • 77955344402 scopus 로고    scopus 로고
    • Lipid accumulation and dendritic cell dysfunction in cancer
    • Herber, D. L. et al. Lipid accumulation and dendritic cell dysfunction in cancer. Nat. Med. 16, 880-886 (2010).
    • (2010) Nat. Med. , vol.16 , pp. 880-886
    • Herber, D.L.1
  • 176
    • 0035182253 scopus 로고    scopus 로고
    • Regulation by chemokines of circulating dendritic cell precursors, and the formation of portal tract-associated lymphoid tissue, in a granulomatous liver disease
    • Yoneyama, H. et al. Regulation by chemokines of circulating dendritic cell precursors, and the formation of portal tract-associated lymphoid tissue, in a granulomatous liver disease. J. Exp. Med. 193, 35-49 (2001).
    • (2001) J. Exp. Med. , vol.193 , pp. 35-49
    • Yoneyama, H.1
  • 177
    • 70449355084 scopus 로고    scopus 로고
    • In liver fibrosis, dendritic cells govern hepatic inflammation in mice via TNF-a
    • Connolly, M. K. et al. In liver fibrosis, dendritic cells govern hepatic inflammation in mice via TNF-a. J. Clin. Invest. 119, 3213-3225 (2009).
    • (2009) J. Clin. Invest. , vol.119 , pp. 3213-3225
    • Connolly, M.K.1
  • 178
    • 77958124602 scopus 로고    scopus 로고
    • Tip-DC development during parasitic infection is regulated by IL-10 and requires CCL2/CCR2 IFN-y and MyD88 signaling
    • Bosschaerts, T. et al. Tip-DC development during parasitic infection is regulated by IL-10 and requires CCL2/CCR2, IFN-y and MyD88 signaling. PLoS Pathog. 6, e1001045 (2010).
    • (2010) PLoS Pathog. , vol.6 , pp. e1001045
    • Bosschaerts, T.1
  • 179
    • 84155175629 scopus 로고    scopus 로고
    • Dendritic cell regulation of carbon tetrachloride-induced murine liver fibrosis regression
    • Jiao, J. et al. Dendritic cell regulation of carbon tetrachloride-induced murine liver fibrosis regression. Hepatology 55, 244-255 (2012).
    • (2012) Hepatology , vol.55 , pp. 244-255
    • Jiao, J.1
  • 180
    • 84856677921 scopus 로고    scopus 로고
    • Role of stress-induced NKG2D ligands in liver diseases
    • Kahraman, A., Fingas, C. D., Syn, W. K., Gerken, G. & Canbay, A. Role of stress-induced NKG2D ligands in liver diseases. Liver Int. 32, 370-382 (2012).
    • (2012) Liver Int. , vol.32 , pp. 370-382
    • Kahraman, A.1    Fingas, C.D.2    Syn, W.K.3    Gerken, G.4    Canbay, A.5
  • 181
    • 84884990148 scopus 로고    scopus 로고
    • Invariant NKT cell activation induces neutrophil accumulation and hepatitis: Opposite regulation by IL-4 and IFN-γ
    • Wang, H., Feng, D., Park, O., Yin, S. & Gao, B. Invariant NKT cell activation induces neutrophil accumulation and hepatitis: opposite regulation by IL-4 and IFN-γ. Hepatology 58, 1474-1485 (2013).
    • (2013) Hepatology , vol.58 , pp. 1474-1485
    • Wang, H.1    Feng, D.2    Park, O.3    Yin, S.4    Gao, B.5
  • 182
    • 84866520055 scopus 로고    scopus 로고
    • Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production
    • Lynch, L. et al. Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production. Immunity 37, 574-587 (2012).
    • (2012) Immunity , vol.37 , pp. 574-587
    • Lynch, L.1
  • 183
    • 78149295999 scopus 로고    scopus 로고
    • Protective role of interleukin-17 in murine NKT cell-driven acute experimental hepatitis
    • Wondimu, Z., Santodomingo-Garzon, T., Le, T. & Swain, M. G. Protective role of interleukin-17 in murine NKT cell-driven acute experimental hepatitis. Am. J. Pathol. 177, 2334-2346 (2010).
    • (2010) Am. J. Pathol. , vol.177 , pp. 2334-2346
    • Wondimu, Z.1    Santodomingo-Garzon, T.2    Le, T.3    Swain, M.G.4
  • 184
    • 84901033141 scopus 로고    scopus 로고
    • STAT4 knockout mice are more susceptible to concanavalin A-induced T-cell hepatitis
    • Wang, Y. et al. STAT4 knockout mice are more susceptible to concanavalin A-induced T-cell hepatitis. Am. J. Pathol. 184, 1785-1794 (2014).
    • (2014) Am. J. Pathol. , vol.184 , pp. 1785-1794
    • Wang, Y.1
  • 185
    • 84863993349 scopus 로고    scopus 로고
    • Retinoic acid alleviates Con A-induced hepatitis and differentially regulates effector production in NKT cells
    • Lee, K.-A. et al. Retinoic acid alleviates Con A-induced hepatitis and differentially regulates effector production in NKT cells. Eur. J. Immunol. 42, 1685-1694 (2012).
    • (2012) Eur. J. Immunol. , vol.42 , pp. 1685-1694
    • Lee, K.-A.1
  • 186
    • 65449152565 scopus 로고    scopus 로고
    • Natural killer T cells regulate the homing of chemokine CXC receptor 3-positive regulatory T cells to the liver in mice
    • Santodomingo-Garzon, T., Han, J., Le, T., Yang, Y. & Swain, M. G. Natural killer T cells regulate the homing of chemokine CXC receptor 3-positive regulatory T cells to the liver in mice. Hepatology 49, 1267-1276 (2009).
    • (2009) Hepatology , vol.49 , pp. 1267-1276
    • Santodomingo-Garzon, T.1    Han, J.2    Le, T.3    Yang, Y.4    Swain, M.G.5
  • 187
    • 84880276248 scopus 로고    scopus 로고
    • Pathogenesis of chronic viral hepatitis: Differential roles of T cells and NK cells
    • Rehermann, B. Pathogenesis of chronic viral hepatitis: differential roles of T cells and NK cells. Nat. Med. 19, 859-868 (2013).
    • (2013) Nat. Med. , vol.19 , pp. 859-868
    • Rehermann, B.1
  • 188
    • 84867218760 scopus 로고    scopus 로고
    • High expression defines a natural killer cell subset that is potentially involved in control of hepatitis C virus replication and modulation of liver fibrosis
    • High expression defines a natural killer cell subset that is potentially involved in control of hepatitis C virus replication and modulation of liver fibrosis. Hepatology 56, 1201-1213 (2012).
    • (2012) Hepatology , vol.56 , pp. 1201-1213
    • Krämer, B.1
  • 189
    • 84863615340 scopus 로고    scopus 로고
    • The CXCR3+CD56Bright phenotype characterizes a distinct NK cell subset with anti-fibrotic potential that shows dys-regulated activity in hepatitis C
    • Eisenhardt, M. et al. The CXCR3+CD56Bright phenotype characterizes a distinct NK cell subset with anti-fibrotic potential that shows dys-regulated activity in hepatitis C. PLoS ONE 7, e38846 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e38846
    • Eisenhardt, M.1
  • 190
    • 84867218760 scopus 로고    scopus 로고
    • High expression defines a natural killer cell subset that is potentially involved in control of hepatitis C virus replication and modulation of liver fibrosis
    • High expression defines a natural killer cell subset that is potentially involved in control of hepatitis C virus replication and modulation of liver fibrosis. Hepatology 56, 1201-1213 (2012).
    • (2012) Hepatology , vol.56 , pp. 1201-1213
    • Kramer, B.1
  • 191
    • 33947411395 scopus 로고    scopus 로고
    • Cytokines induced during chronic hepatitis B virus infection promote a pathway for NK cell-mediated liver damage
    • Dunn, C. et al. Cytokines induced during chronic hepatitis B virus infection promote a pathway for NK cell-mediated liver damage. J. Exp. Med. 204, 667-680 (2007).
    • (2007) J. Exp. Med. , vol.204 , pp. 667-680
    • Dunn, C.1
  • 192
    • 84874543706 scopus 로고    scopus 로고
    • Up-regulation of a death receptor renders antiviral T cells susceptible to NK cell-mediated deletion
    • Peppa, D. et al. Up-regulation of a death receptor renders antiviral T cells susceptible to NK cell-mediated deletion. J. Exp. Med. 210, 99-114 (2013).
    • (2013) J. Exp. Med. , vol.210 , pp. 99-114
    • Peppa, D.1
  • 193
    • 84863707404 scopus 로고    scopus 로고
    • Hepatitis B virus-induced lipid alterations contribute to natural killer T cell-dependent protective immunity
    • Zeissig, S. et al. Hepatitis B virus-induced lipid alterations contribute to natural killer T cell-dependent protective immunity. Nat. Med. 18, 1060-1068 (2012).
    • (2012) Nat. Med. , vol.18 , pp. 1060-1068
    • Zeissig, S.1
  • 194
    • 33846798498 scopus 로고    scopus 로고
    • CD1 expression and CD1-restricted T cell activity in normal and tumour-bearing human liver
    • Kenna, T. et al. CD1 expression and CD1-restricted T cell activity in normal and tumour-bearing human liver. Cancer Immunol. Immunother. 56, 563-572 (2007).
    • (2007) Cancer Immunol. Immunother. , vol.56 , pp. 563-572
    • Kenna, T.1
  • 195
    • 84942553335 scopus 로고    scopus 로고
    • The biliary epithelium presents antigens to and activates natural killer T cells
    • Schrumpf, E. et al. The biliary epithelium presents antigens to and activates natural killer T cells. Hepatology 62, 1249-1259 (2015).
    • (2015) Hepatology , vol.62 , pp. 1249-1259
    • Schrumpf, E.1
  • 196
    • 84901331442 scopus 로고    scopus 로고
    • The liver may act as a firewall mediating mutualism between the host and its gut commensal microbiota
    • Balmer, M. L. et al. The liver may act as a firewall mediating mutualism between the host and its gut commensal microbiota. Sci. Transl. Med. 6, 237ra66 (2014).
    • (2014) Sci. Transl. Med. , vol.6 , pp. 237ra66
    • Balmer, M.L.1
  • 197
    • 84925362128 scopus 로고    scopus 로고
    • IL-22 and IL-22 binding protein (IL-22BP) regulate fibrosis and cirrhosis in hepatitis C virus and schistosome infections
    • Sertorio, M. et al. IL-22 and IL-22 binding protein (IL-22BP) regulate fibrosis and cirrhosis in hepatitis C virus and schistosome infections. Hepatology 61, 1321-1331 (2015).
    • (2015) Hepatology , vol.61 , pp. 1321-1331
    • Sertorio, M.1
  • 198
    • 84865564349 scopus 로고    scopus 로고
    • Interleukin-22 induces hepatic stellate cell senescence and restricts liver fibrosis in mice
    • Kong, X. et al. Interleukin-22 induces hepatic stellate cell senescence and restricts liver fibrosis in mice. Hepatology 56, 1150-1159 (2012).
    • (2012) Hepatology , vol.56 , pp. 1150-1159
    • Kong, X.1
  • 199
    • 84860596931 scopus 로고    scopus 로고
    • NKp46-mediated killing of human and mouse hepatic stellate cells attenuates liver fibrosis
    • Gur, C. et al. NKp46-mediated killing of human and mouse hepatic stellate cells attenuates liver fibrosis. Gut 61, 885-893 (2012).
    • (2012) Gut , vol.61 , pp. 885-893
    • Gur, C.1
  • 200
    • 84892394789 scopus 로고    scopus 로고
    • Natural killer cell-dependent anti-fibrotic pathway in liver injury via Toll-like receptor-9
    • Abu-Tair, L. et al. Natural killer cell-dependent anti-fibrotic pathway in liver injury via Toll-like receptor-9. PLoS ONE 8, e82571 (2013).
    • (2013) PLoS ONE , vol.8 , pp. e82571
    • Abu-Tair, L.1
  • 201
    • 66149098871 scopus 로고    scopus 로고
    • Diverse roles of invariant natural killer T cells in liver injury and fibrosis induced by carbon tetrachloride
    • Park, O. et al. Diverse roles of invariant natural killer T cells in liver injury and fibrosis induced by carbon tetrachloride. Hepatology 49, 1683-1694 (2009).
    • (2009) Hepatology , vol.49 , pp. 1683-1694
    • Park, O.1
  • 202
    • 77952730087 scopus 로고    scopus 로고
    • Accumulation of natural killer T cells in progressive nonalcoholic fatty liver disease
    • Syn, W. K. et al. Accumulation of natural killer T cells in progressive nonalcoholic fatty liver disease. Hepatology 51, 1998-2007 (2010).
    • (2010) Hepatology , vol.51 , pp. 1998-2007
    • Syn, W.K.1
  • 203
    • 84907976095 scopus 로고    scopus 로고
    • + T cells and NKT cells causes nonalcoholic steatohepatitis and liver cancer via cross-talk with hepatocytes
    • + T cells and NKT cells causes nonalcoholic steatohepatitis and liver cancer via cross-talk with hepatocytes. Cancer Cell 26, 549-564 (2014).
    • (2014) Cancer Cell , vol.26 , pp. 549-564
    • Wolf, M.J.1
  • 204
    • 77954701928 scopus 로고    scopus 로고
    • Human mucosal associated invariant T cells detect bacterially infected cells
    • Gold, M. C. et al. Human mucosal associated invariant T cells detect bacterially infected cells. PLoS Biol. 8, e1000407 (2010).
    • (2010) PLoS Biol. , vol.8 , pp. e1000407
    • Gold, M.C.1
  • 205
    • 84887281193 scopus 로고    scopus 로고
    • MAIT cells detect and efficiently lyse bacterially-infected epithelial cells
    • Le Bourhis, L. et al. MAIT cells detect and efficiently lyse bacterially-infected epithelial cells. PLoS Pathog. 9, e1003681 (2013).
    • (2013) PLoS Pathog. , vol.9 , pp. e1003681
    • Le Bourhis, L.1
  • 206
    • 62349099352 scopus 로고    scopus 로고
    • Hepatic interleukin-7 expression regulates T cell responses
    • Sawa, Y. et al. Hepatic interleukin-7 expression regulates T cell responses. Immunity 30, 447-457 (2009).
    • (2009) Immunity , vol.30 , pp. 447-457
    • Sawa, Y.1
  • 207
    • 84903482908 scopus 로고    scopus 로고
    • Toll-like receptor 8 agonist and bacteria trigger potent activation of innate immune cells in human liver
    • Jo, J. et al. Toll-like receptor 8 agonist and bacteria trigger potent activation of innate immune cells in human liver. PLoS Pathog. 10, e1004210 (2014).
    • (2014) PLoS Pathog. , vol.10 , pp. e1004210
    • Jo, J.1
  • 208
    • 0025881160 scopus 로고
    • Memory T cells represent the predominant lymphocyte subset in acute and chronic liver inflammation
    • Volpes, R., van den Oord, J. J. & Desmet, V. J. Memory T cells represent the predominant lymphocyte subset in acute and chronic liver inflammation. Hepatology 13, 826-829 (1991).
    • (1991) Hepatology , vol.13 , pp. 826-829
    • Volpes, R.1    Van Den Oord, J.J.2    Desmet, V.J.3
  • 209
    • 84875809649 scopus 로고    scopus 로고
    • Liver-primed memory T cells generated under noninflammatory conditions provide anti-infectious immunity
    • Bottcher, J. P. et al. Liver-primed memory T cells generated under noninflammatory conditions provide anti-infectious immunity. Cell Rep. 3, 779-795 (2013).
    • (2013) Cell Rep. , vol.3 , pp. 779-795
    • Bottcher, J.P.1
  • 210
    • 84932110028 scopus 로고    scopus 로고
    • Intrahepatic regulatory T cells in autoimmune hepatitis are associated with treatment response and depleted with current therapies
    • Taubert, R. et al. Intrahepatic regulatory T cells in autoimmune hepatitis are associated with treatment response and depleted with current therapies. J. Hepatol. 61, 1106-1114 (2014).
    • (2014) J. Hepatol. , vol.61 , pp. 1106-1114
    • Taubert, R.1
  • 211
    • 77956643943 scopus 로고    scopus 로고
    • A multifaceted imbalance of T cells with regulatory function characterizes type 1 autoimmune hepatitis
    • Ferri, S. et al. A multifaceted imbalance of T cells with regulatory function characterizes type 1 autoimmune hepatitis. Hepatology 52, 999-1007 (2010).
    • (2010) Hepatology , vol.52 , pp. 999-1007
    • Ferri, S.1
  • 212
    • 84919442232 scopus 로고    scopus 로고
    • Role of gamma-delta T cells in liver inflammation and fibrosis
    • Hammerich, L. & Tacke, F. Role of gamma-delta T cells in liver inflammation and fibrosis. World J. Gastrointest. Pathophysiol. 5, 107-113 (2014).
    • (2014) World J. Gastrointest. Pathophysiol. , vol.5 , pp. 107-113
    • Hammerich, L.1    Tacke, F.2
  • 213
    • 84979850744 scopus 로고    scopus 로고
    • The concanavalin A model of acute hepatitis in mice
    • Heymann, F., Hamesch, K., Weiskirchen, R. & Tacke, F. The concanavalin A model of acute hepatitis in mice. Lab. Anim. 49, 12-20 (2015).
    • (2015) Lab. Anim. , vol.49 , pp. 12-20
    • Heymann, F.1    Hamesch, K.2    Weiskirchen, R.3    Tacke, F.4
  • 214
    • 0026643743 scopus 로고
    • T cell-dependent experimental liver injury in mice inducible by concanavalin A
    • Tiegs, G., Hentschel, J. & Wendel, A. A. T cell-dependent experimental liver injury in mice inducible by concanavalin A. J. Clin. Invest. 90, 196-203 (1992).
    • (1992) J. Clin. Invest. , vol.90 , pp. 196-203
    • Tiegs, G.1    Hentschel, J.2    Wendel, A.A.3
  • 215
    • 84888374898 scopus 로고    scopus 로고
    • Hepatocytes contribute to immune regulation in the liver by activation of the Notch signaling pathway in T cells
    • Burghardt, S. et al. Hepatocytes contribute to immune regulation in the liver by activation of the Notch signaling pathway in T cells. J. Immunol. 191, 5574-5582 (2013).
    • (2013) J. Immunol. , vol.191 , pp. 5574-5582
    • Burghardt, S.1
  • 216
    • 84893650001 scopus 로고    scopus 로고
    • Chemokine receptor CCR6-dependent accumulation of γδ T cells in injured liver restricts hepatic inflammation and fibrosis
    • Hammerich, L. et al. Chemokine receptor CCR6-dependent accumulation of γδ T cells in injured liver restricts hepatic inflammation and fibrosis. Hepatology 59, 630-642 (2014).
    • (2014) Hepatology , vol.59 , pp. 630-642
    • Hammerich, L.1
  • 217
  • 218
    • 33344467532 scopus 로고    scopus 로고
    • + T cells activated locally within the transplanted liver
    • + T cells activated locally within the transplanted liver. J. Exp. Med. 203, 437-447 (2006).
    • (2006) J. Exp. Med. , vol.203 , pp. 437-447
    • Klein, I.1    Crispe, I.N.2
  • 219
    • 72949086418 scopus 로고    scopus 로고
    • CD4 T cells promote tissue inflammation via CD40 signaling without de novo activation in a murine model of liver ischemia/reperfusion injury
    • Shen, X. et al. CD4 T cells promote tissue inflammation via CD40 signaling without de novo activation in a murine model of liver ischemia/reperfusion injury. Hepatology 50, 1537-1546 (2009).
    • (2009) Hepatology , vol.50 , pp. 1537-1546
    • Shen, X.1
  • 220
    • 84921496569 scopus 로고    scopus 로고
    • Immunological aspects of antiviral therapy of chronic hepatitis B virus and hepatitis C virus infections
    • Rehermann, B. & Bertoletti, A. Immunological aspects of antiviral therapy of chronic hepatitis B virus and hepatitis C virus infections. Hepatology 61, 712-721 (2015).
    • (2015) Hepatology , vol.61 , pp. 712-721
    • Rehermann, B.1    Bertoletti, A.2
  • 221
    • 77956630526 scopus 로고    scopus 로고
    • + T cells by adeno-associated virus-transduced hepatocytes
    • + T cells by adeno-associated virus-transduced hepatocytes. Hepatology 52, 1068-1077 (2010).
    • (2010) Hepatology , vol.52 , pp. 1068-1077
    • Wuensch, S.A.1    Spahn, J.2    Crispe, I.N.3
  • 222
    • 80055007453 scopus 로고    scopus 로고
    • + T-cell immunity to adeno-associated virus can result in prolonged liver injury and fibrogenesis
    • + T-cell immunity to adeno-associated virus can result in prolonged liver injury and fibrogenesis. Am. J. Pathol. 179, 2370-2381 (2011).
    • (2011) Am. J. Pathol. , vol.179 , pp. 2370-2381
    • Spahn, J.1    Pierce, R.H.2    Crispe, I.N.3
  • 223
    • 30744437415 scopus 로고    scopus 로고
    • Platelets mediate cytotoxic T lymphocyte-induced liver damage
    • Iannacone, M. et al. Platelets mediate cytotoxic T lymphocyte-induced liver damage. Nat. Med. 11, 1167-1169 (2005).
    • (2005) Nat. Med. , vol.11 , pp. 1167-1169
    • Iannacone, M.1
  • 224
    • 84935488734 scopus 로고    scopus 로고
    • + T cells
    • + T cells. Cell 161, 486-500 (2015).
    • (2015) Cell , vol.161 , pp. 486-500
    • Guidotti, L.G.1
  • 226
    • 84882845968 scopus 로고    scopus 로고
    • + T cell stimulation of NK cell anti-fibrotic activity may contribute to accelerated liver fibrosis progression in HIV/HCV patients
    • + T cell stimulation of NK cell anti-fibrotic activity may contribute to accelerated liver fibrosis progression in HIV/HCV patients. J. Hepatol. 59, 427-433 (2013).
    • (2013) J. Hepatol. , vol.59 , pp. 427-433
    • Glässner, A.1
  • 227
    • 84905984580 scopus 로고    scopus 로고
    • + T cell exhaustion in hepatitis B virus-induced immunotolerance
    • + T cell exhaustion in hepatitis B virus-induced immunotolerance. J. Immunol. 193, 1645-1653 (2014).
    • (2014) J. Immunol. , vol.193 , pp. 1645-1653
    • Kong, X.1    Sun, R.2    Chen, Y.3    Wei, H.4    Tian, Z.5
  • 228
    • 80053651902 scopus 로고    scopus 로고
    • Interleukin-17 exacerbates hepatic steatosis and inflammation in non-alcoholic fatty liver disease
    • Tang, Y. et al. Interleukin-17 exacerbates hepatic steatosis and inflammation in non-alcoholic fatty liver disease. Clin. Exp. Immunol. 166, 281-290 (2011).
    • (2011) Clin. Exp. Immunol. , vol.166 , pp. 281-290
    • Tang, Y.1
  • 229
    • 84896722464 scopus 로고    scopus 로고
    • Adaptive immune responses triggered by oxidative stress contribute to hepatic inflammation in NASH
    • Sutti, S. et al. Adaptive immune responses triggered by oxidative stress contribute to hepatic inflammation in NASH. Hepatology 59, 886-897 (2014).
    • (2014) Hepatology , vol.59 , pp. 886-897
    • Sutti, S.1
  • 230
    • 84927761703 scopus 로고    scopus 로고
    • Dual role of B7 costimulation in obesity-related nonalcoholic steatohepatitis and metabolic dysregulation
    • Chatzigeorgiou, A. et al. Dual role of B7 costimulation in obesity-related nonalcoholic steatohepatitis and metabolic dysregulation. Hepatology 60, 1196-1210 (2014).
    • (2014) Hepatology , vol.60 , pp. 1196-1210
    • Chatzigeorgiou, A.1
  • 231
    • 34447503805 scopus 로고    scopus 로고
    • Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid
    • Mucida, D. et al. Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science 317, 256-260 (2007).
    • (2007) Science , vol.317 , pp. 256-260
    • Mucida, D.1
  • 232
    • 84884836878 scopus 로고    scopus 로고
    • Biliary obstruction results in PD-1-dependent liver T cell dysfunction and acute inflammation mediated by Th17 cells and neutrophils
    • Licata, L. A. et al. Biliary obstruction results in PD-1-dependent liver T cell dysfunction and acute inflammation mediated by Th17 cells and neutrophils. J. Leukoc. Biol. 94, 813-823 (2013).
    • (2013) J. Leukoc. Biol. , vol.94 , pp. 813-823
    • Licata, L.A.1
  • 233
    • 84894728578 scopus 로고    scopus 로고
    • Cannabinoid receptor 2 counteracts interleukin-17-induced immune and fibrogenic responses in mouse liver
    • Guillot, A. et al. Cannabinoid receptor 2 counteracts interleukin-17-induced immune and fibrogenic responses in mouse liver. Hepatology 59, 296-306 (2014).
    • (2014) Hepatology , vol.59 , pp. 296-306
    • Guillot, A.1
  • 234
    • 33745003240 scopus 로고    scopus 로고
    • CB1 cannabinoid receptor antagonism: A new strategy for the treatment of liver fibrosis
    • Teixeira-Clerc, F. et al. CB1 cannabinoid receptor antagonism: a new strategy for the treatment of liver fibrosis. Nat. Med. 12, 671-676 (2006).
    • (2006) Nat. Med. , vol.12 , pp. 671-676
    • Teixeira-Clerc, F.1
  • 235
    • 81855209855 scopus 로고    scopus 로고
    • Accelerated and progressive and lethal liver fibrosis in mice that lack interleukin (IL)-10, IL-12p40, and IL-13R α2
    • Mentink-Kane, M. M. et al. Accelerated and progressive and lethal liver fibrosis in mice that lack interleukin (IL)-10, IL-12p40, and IL-13R α2. Gastroenterology 141, 2200-2209 (2011).
    • (2011) Gastroenterology , vol.141 , pp. 2200-2209
    • Mentink-Kane, M.M.1
  • 236
    • 84923855044 scopus 로고    scopus 로고
    • Blockade of PD1 and TIM3 restores innate and adaptive immunity in patients with acute alcoholic hepatitis
    • Markwick, L. J. L. et al. Blockade of PD1 and TIM3 restores innate and adaptive immunity in patients with acute alcoholic hepatitis. Gastroenterology 148, 590-602.e10 (2015).
    • (2015) Gastroenterology , vol.148 , pp. 590-590e10
    • Markwick, L.J.L.1
  • 237
    • 79955565441 scopus 로고    scopus 로고
    • Fibrosis is regulated by Th2 and Th17 responses and by dynamic interactions between fibroblasts and macrophages
    • Barron, L. & Wynn, T. A. Fibrosis is regulated by Th2 and Th17 responses and by dynamic interactions between fibroblasts and macrophages. Am. J. Physiol. Gastrointest. Liver Physiol. 300, G723-G728 (2011).
    • (2011) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.300 , pp. G723-G728
    • Barron, L.1    Wynn, T.A.2
  • 238
    • 84881393577 scopus 로고    scopus 로고
    • IL-17A plays a critical role in the pathogenesis of liver fibrosis through hepatic stellate cell activation
    • Tan, Z. et al. IL-17A plays a critical role in the pathogenesis of liver fibrosis through hepatic stellate cell activation. J. Immunol. 191, 1835-1844 (2013).
    • (2013) J. Immunol. , vol.191 , pp. 1835-1844
    • Tan, Z.1
  • 239
    • 84866180909 scopus 로고    scopus 로고
    • Gut-derived lipopolysaccharide promotes T-cell-mediated hepatitis in mice through Toll-like receptor 4
    • Lin, Y. et al. Gut-derived lipopolysaccharide promotes T-cell-mediated hepatitis in mice through Toll-like receptor 4. Cancer Prev. Res. (Phila.) 5, 1090-1102 (2012).
    • (2012) Cancer Prev. Res. (Phila.) , vol.5 , pp. 1090-1102
    • Lin, Y.1
  • 240
    • 84865461464 scopus 로고    scopus 로고
    • Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice
    • Meng, F. et al. Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice. Gastroenterology 143, 765-776.e1-3 (2012).
    • (2012) Gastroenterology , vol.143 , pp. 765-776e13
    • Meng, F.1
  • 241
    • 84896806249 scopus 로고    scopus 로고
    • Liver fibrosis and repair: Immune regulation of wound healing in a solid organ
    • Pellicoro, A., Ramachandran, P., Iredale, J. P. & Fallowfield, J. A. Liver fibrosis and repair: immune regulation of wound healing in a solid organ. Nat. Rev. Immunol. 14, 181-194 (2014).
    • (2014) Nat. Rev. Immunol. , vol.14 , pp. 181-194
    • Pellicoro, A.1    Ramachandran, P.2    Iredale, J.P.3    Fallowfield, J.A.4
  • 242
    • 84892469998 scopus 로고    scopus 로고
    • CCL20 mediates lipopolysaccharide induced liver injury and is a potential driver of inflammation and fibrosis in alcoholic hepatitis
    • Affò, S. et al. CCL20 mediates lipopolysaccharide induced liver injury and is a potential driver of inflammation and fibrosis in alcoholic hepatitis. Gut 63, 1782-1792 (2014).
    • (2014) Gut , vol.63 , pp. 1782-1792
    • Affò, S.1
  • 243
    • 84859812538 scopus 로고    scopus 로고
    • Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4
    • Dapito, D. H. et al. Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4. Cancer Cell 21, 504-516 (2012).
    • (2012) Cancer Cell , vol.21 , pp. 504-516
    • Dapito, D.H.1
  • 244
    • 84941944562 scopus 로고    scopus 로고
    • Mechanisms of liver fibrosis resolution
    • Tacke, F. & Trautwein, C. Mechanisms of liver fibrosis resolution. J. Hepatol. 63, 1038-1039 (2015).
    • (2015) J. Hepatol. , vol.63 , pp. 1038-1039
    • Tacke, F.1    Trautwein, C.2
  • 245
    • 79955701910 scopus 로고    scopus 로고
    • Scraping fibrosis: Expressway to the core of fibrosis
    • Mehal, W. Z., Iredale, J. & Friedman, S. L. Scraping fibrosis: expressway to the core of fibrosis. Nat. Med. 17, 552-553 (2011).
    • (2011) Nat. Med. , vol.17 , pp. 552-553
    • Mehal, W.Z.1    Iredale, J.2    Friedman, S.L.3
  • 247
    • 84928910362 scopus 로고    scopus 로고
    • Role of lymphocytes in liver cancer
    • Mossanen, J. C. & Tacke, F. Role of lymphocytes in liver cancer. Oncoimmunology 2, e26468 (2013).
    • (2013) Oncoimmunology , vol.2 , pp. e26468
    • Mossanen, J.C.1    Tacke, F.2
  • 248
    • 84929606405 scopus 로고    scopus 로고
    • Resolution of liver fibrosis requires myeloid cell-driven sinusoidal angiogenesis
    • Kantari-Mimoun, C. et al. Resolution of liver fibrosis requires myeloid cell-driven sinusoidal angiogenesis. Hepatology 61, 2042-2055 (2014).
    • (2014) Hepatology , vol.61 , pp. 2042-2055
    • Kantari-Mimoun, C.1


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