Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome

Journal of Clinical Investigation

Volumn 119, Issue 2, 2009, Pages 305-314

  Imaeda, Avlin B ^a   Watanabe, Azuma ^a   Sohail, Muhammad A ^a   Mahmood, Shamail ^a   Mohamadnejad, Mehdi ^a   Sutterwala, Fayyaz S ^b   Flavell, Richard A ^c   Mehal, Wajahat Z ^a,c  

^a YALE UNIVERSITY   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 (4 CHLOROPHENYL) 1 (4 METHOXYPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOLE; ACETYLSALICYLIC ACID; ADAPTOR PROTEIN; CLOPIDOGREL; CRYOPYRIN; CYCLOOXYGENASE 1; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; PARACETAMOL; PROTEIN ASC; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG; ANALGESIC AGENT; CARRIER PROTEIN; CIAS1 PROTEIN, MOUSE; PROSTAGLANDIN SYNTHASE INHIBITOR; TLR9 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DEGRANULATION; DOWN REGULATION; DRUG EFFECT; ENZYME ACTIVATION; ENZYME INHIBITION; GENE ACTIVATION; INNATE IMMUNITY; LIVER CELL; LIVER SINUSOID; LIVER TOXICITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; SIGNAL TRANSDUCTION; THROMBOCYTE; ANIMAL; APOPTOSIS; BIOSYNTHESIS; C57BL MOUSE; CELL LINE; CHEMICALLY INDUCED DISORDER; DOSE RESPONSE; DRUG ANTAGONISM; HUMAN; INFLAMMATION; LIVER; PATHOLOGY; PHYSIOLOGY;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANIMALS; APOPTOSIS; ASPIRIN; CARRIER PROTEINS; CASPASE 1; CELL LINE; CYCLOOXYGENASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; IMMUNITY, INNATE; INFLAMMATION; INTERLEUKIN-18; INTERLEUKIN-1BETA; LIVER; MICE; MICE, INBRED C57BL; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 9;

EID: 61749099391     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI35958     Document Type: Article

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