STAT4 knockout mice are more susceptible to concanavalin A-induced T-cell hepatitis

American Journal of Pathology

Volumn 184, Issue 6, 2014, Pages 1785-1794

  Wang, Yan ^a,b   Feng, Dechun ^a   Wang, Hua ^a   Xu, Ming Jiang ^a   Park, Ogyi ^a   Li, Yongmei ^a   Gao, Bin ^a  

^a NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^b PEKING UNIVERSITY FIRST HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CONCANAVALIN A; FAS LIGAND; INTERLEUKIN 12P35; INTERLEUKIN 12P40; STAT4 PROTEIN; IL12A PROTEIN, MOUSE; MITOGENIC AGENT; STAT4 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE HEPATITIS; CHRONIC LIVER DISEASE; CONTROLLED STUDY; CYTOTOXICITY; DISEASE EXACERBATION; HEPATITIS; HUMAN; HUMAN TISSUE; IMMUNOCOMPETENT CELL; IN VITRO STUDY; KNOCKOUT MOUSE; KUPFFER CELL; LIVER CELL; LIVER CELL DAMAGE; LIVER INJURY; MACROPHAGE; MALE; MOUSE; MURINE HEPATITIS; NATURAL KILLER T CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; T LYMPHOCYTE; TH1 CELL; TH2 CELL; WILD TYPE; ACUTE DISEASE; ANIMAL; GENETICS; IMMUNOLOGY; PATHOLOGY; TOXIC HEPATITIS;

ACUTE DISEASE; ANIMALS; CONCANAVALIN A; DRUG-INDUCED LIVER INJURY; HEPATOCYTES; INTERLEUKIN-12 SUBUNIT P35; MICE; MICE, KNOCKOUT; MITOGENS; NATURAL KILLER T-CELLS; STAT4 TRANSCRIPTION FACTOR;

EID: 84901033141     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2014.02.023     Document Type: Article

References (40)

1. G. Tiegs Cellular and cytokine-mediated mechanisms of inflammation and its modulation in immune-mediated liver injury Z Gastroenterol 45 2007 63 70
2. R. Xu, Z. Zhang, and F.S. Wang Liver fibrosis: mechanisms of immune-mediated liver injury Cell Mol Immunol 9 2012 296 301
3. P. Kubes, and W.Z. Mehal Sterile inflammation in the liver Gastroenterology 143 2012 1158 1172
4. G. Szabo, and T. Csak Inflammasomes in liver diseases J Hepatol 57 2012 642 654
5. D.H. Adams, C. Ju, S.K. Ramaiah, J. Uetrecht, and H. Jaeschke Mechanisms of immune-mediated liver injury Toxicol Sci 115 2010 307 321
6. V. Zimmer, and F. Lammert Genetics in liver disease: new concepts Curr Opin Gastroenterol 27 2011 231 239
7. M. Krawczyk, R. Müllenbach, S.N. Weber, V. Zimmer, and F. Lammert Genome-wide association studies and genetic risk assessment of liver diseases Nat Rev Gastroenterol Hepatol 7 2010 669 681
8. T.H. Karlsen, E. Melum, and A. Franke The utility of genome-wide association studies in hepatology Hepatology 51 2010 1833 1842
9. D.K. Jiang, J. Sun, G. Cao, Y. Liu, D. Lin, and Y.Z. Gao et al. Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma Nat Genet 45 2013 72 75
10. G.F. Mells, J.A.B. Floyd, K.I. Morley, H.J. Cordell, C.S. Franklin, S.Y. Shin, M.A. Heneghan, J.M. Neuberger, P.T. Donaldson, D.B. Day, S.J. Ducker, A.W. Muriithi, E.F. Wheater, C.J. Hammond, M.F. Dawwas, P. Richardson, I. Nasr, R.J. Aspinall UK PBC Consortium; Wellcome Trust Case Control Consortium 3 D.E. Jones, L. Peltonen, G.J. Alexander, R.N. Sandford, and C.A. Anderson Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis Nat Genet 43 2011 329 332
11. G.M. Hirschfield, R.W. Chapman, T.H. Karlsen, F. Lammert, K.N. Lazaridis, and A.L. Mason The genetics of complex cholestatic disorders Gastroenterology 144 2013 1357 1374
12. D. Eurich, S. Boas-Knoop, B. Struecker, R. Neuhaus, P. Neuhaus, and M. Bahra Genetic variants of STAT-4 affect the development of graft fibrosis after liver transplantation for HCV-induced liver disease Transplantation 95 2013 203 208
13. B. Gao, H. Wang, F. Lafdil, and D. Feng STAT proteins-key regulators of anti-viral responses, inflammation, and tumorigenesis in the liver J Hepatol 57 2012 430 441
14. F. Hong, B. Jaruga, W.H. Kim, S. Radaeva, O.N. El-Assal, Z. Tian, V.A. Nguyen, and B. Gao Opposing roles of STAT1 and STAT3 in T cell-mediated hepatitis: regulation by SOCS J Clin Invest 110 2002 1503 1513
15. B. Jaruga, F. Hong, R. Sun, S. Radaeva, and B. Gao Crucial role of IL-4/STAT6 in T cell-mediated hepatitis: up-regulating eotaxins and IL-5 and recruiting leukocytes J Immunol 171 2003 3233 3244
16. S. Radaeva, R. Sun, H.N. Pan, F. Hong, and B. Gao Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation Hepatology 39 2004 1332 1342
17. S.S. Cho, C.M. Bacon, C. Sudarshan, R.C. Rees, D. Finbloom, R. Pine, and J.J. O'Shea Activation of STAT4 by IL-12 and IFN-alpha: evidence for the involvement of ligand-induced tyrosine and serine phosphorylation J Immunol 157 1996 4781 4789
18. C.M. Bacon, S.S. Cho, and J.J. O'Shea Signal transduction by interleukin-12 and interleukin-2. A comparison and contrast Ann N Y Acad Sci 795 1996 41 59
19. A. Morinobu, M. Gadina, W. Strober, R. Visconti, A. Fornace, C. Montagna, G.M. Feldman, R. Nishikomori, and J.J. O'Shea STAT4 serine phosphorylation is critical for IL-12-induced IFN-gamma production but not for cell proliferation Proc Natl Acad Sci USA 99 2002 12281 12286
20. S.V. Subramaniam, R.S. Cooper, and S.E. Adunyah Evidence for the involvement of JAK/STAT pathway in the signaling mechanism of interleukin-17 Biochem Biophys Res Commun 262 1999 14 19
21. M.H. Kaplan STAT4: a critical regulator of inflammation in vivo Immunol Res 31 2005 231 242
22. M.C. Rodriguez-Galan, D. Reynolds, S.G. Correa, P. Iribarren, M. Watanabe, and H.A. Young Coexpression of IL-18 strongly attenuates IL-12-induced systemic toxicity through a rapid induction of IL-10 without affecting its antitumor capacity J Immunol 183 2009 740 748
23. M. Tsuda, W. Zhang, G.X. Yang, K. Tsuneyama, Y. Ando, K. Kawata, O. Park, P.S. Leung, R.L. Coppel, A.A. Ansari, W.M. Ridgway, B. Gao, Z.X. Lian, R. Flavell, X.S. He, and M.E. Gershwin Deletion of interleukin (IL)-12p35 induces liver fibrosis in dominant-negative TGFbeta receptor type II mice Hepatology 57 2013 806 816
24. R. Zhu, S. Diem, L.M. Araujo, A. Aumeunier, J. Denizeau, E. Philadelphe, D. Damotte, M. Samson, P. Gourdy, M. Dy, E. Schneider, and A. Herbelin The pro-Th1 cytokine IL-12 enhances IL-4 production by invariant NKT cells: relevance for T cell-mediated hepatitis J Immunol 178 2007 5435 5442
25. C.J. Chang, Y.H. Chen, K.W. Huang, H.W. Cheng, S.F. Chan, K.F. Tai, and L.H. Hwang Combined GM-CSF and IL-12 gene therapy synergistically suppresses the growth of orthotopic liver tumors Hepatology 45 2007 746 754
26. X.D. Shen, B. Ke, Y. Zhai, F. Gao, D. Anselmo, C.R. Lassman, R.W. Busuttil, and J.W. Kupiec-Weglinski Stat4 and Stat6 signaling in hepatic ischemia/reperfusion injury in mice: HO-1 dependence of Stat4 disruption-mediated cytoprotection Hepatology 37 2003 296 303
27. A. Kato, A. Graul-Layman, M.J. Edwards, and A.B. Lentsch Promotion of hepatic ischemia/reperfusion injury by IL-12 is independent of STAT4 Transplantation 73 2002 1142 1145
28. H. Wang, D. Feng, O. Park, S. Yin, and B. Gao Invariant NKT cell activation induces neutrophil accumulation and hepatitis: opposite regulation by IL-4 and IFN-γ Hepatology 58 2013 1474 1485
29. W.J. Leonard, and J.J. O'Shea Jaks and STATs: biological implications Annu Rev Immunol 16 1998 293 322
30. R. Nishikomori, T. Usui, C.Y. Wu, A. Morinobu, J.J. O'Shea, and W. Strober Activated STAT4 has an essential role in Th1 differentiation and proliferation that is independent of its role in the maintenance of IL-12R beta 2 chain expression and signaling J Immunol 169 2002 4388 4398
31. C.M. Bacon, E.F. Petricoin III, J.R. Ortaldo, R.C. Rees, A.C. Larner, J.A. Johnston, and J.J. O'Shea Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes Proc Natl Acad Sci USA 92 1995 7307 7311
32. T. Miyagi, M.P. Gil, X. Wang, J. Louten, W.M. Chu, and C.A. Biron High basal STAT4 balanced by STAT1 induction to control type 1 interferon effects in natural killer cells J Exp Med 204 2007 2383 2396
33. K. Takeda, Y. Hayakawa, L. Van Kaer, H. Matsuda, H. Yagita, and K. Okumura Critical contribution of liver natural killer T cells to a murine model of hepatitis Proc Natl Acad Sci USA 97 2000 5498 5503
34. K. Gee, C. Guzzo, N.F. Che Mat, W. Ma, and A. Kumar The IL-12 family of cytokines in infection, inflammation and autoimmune disorders Inflamm Allergy Drug Targets 8 2009 40 52
35. F. Nicoletti, R. Di Marco, P. Zaccone, A. Salvaggio, G. Magro, K. Bendtzen, and P. Meroni Murine concanavalin A-induced hepatitis is prevented by interleukin 12 (IL-12) antibody and exacerbated by exogenous IL-12 through an interferon-gamma-dependent mechanism Hepatology 32 2000 728 733
36. Y. Kaneko, M. Harada, T. Kawano, M. Yamashita, Y. Shibata, F. Gejyo, T. Nakayama, and M. Taniguchi Augmentation of Valpha14 NKT cell-mediated cytotoxicity by interleukin 4 in an autocrine mechanism resulting in the development of concanavalin A-induced hepatitis J Exp Med 191 2000 105 114
37. H.M. Ni, X. Chen, W.X. Ding, M. Schuchmann, and X.M. Yin Differential roles of JNK in ConA/GalN and ConA-induced liver injury in mice Am J Pathol 173 2008 962 972
38. K. Seino, N. Kayagaki, K. Takeda, K. Fukao, K. Okumura, and H. Yagita Contribution of Fas ligand to T cell-mediated hepatic injury in mice Gastroenterology 113 1997 1315 1322
39. Y. Tagawa, S. Kakuta, and Y. Iwakura Involvement of Fas/Fas ligand system-mediated apoptosis in the development of concanavalin A-induced hepatitis Eur J Immunol 28 1998 4105 4113
40. M. Fujino, M. Kawasaki, N. Funeshima, Y. Kitazawa, M. Kosuga, K. Okabe, M. Hashimoto, H. Yaginuma, K. Mikoshiba, T. Okuyama, S. Suzuki, and X.K. Li CrmA gene expression protects mice against concanavalin-A-induced hepatitis by inhibiting IL-18 secretion and hepatocyte apoptosis Gene Ther 10 2003 1781 1790