A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse

Journal of Hepatology

Volumn 60, Issue 4, 2014, Pages 782-791

  Moles, Anna ^a   Murphy, Lindsay ^a   Wilson, Caroline L ^a   Chakraborty, Jayashree Bagchi ^a   Fox, Christopher ^a   Park, Eek Joong ^b   Mann, Jelena ^a   Oakley, Fiona ^a   Howarth, Rachel ^a   Brain, John ^a   Masson, Steven ^a   Karin, Michael ^c   Seki, Ekihiro ^b   Mann, Derek A ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Inflammation; Liver fibrosis; Neutrophil; S100A9; Toll like receptor

Indexed keywords

ALANINE AMINOTRANSFERASE; CALGRANULIN; CALGRANULIN B; CARBON TETRACHLORIDE; CXCL1 CHEMOKINE; CXCL2 CHEMOKINE; TOLL LIKE RECEPTOR 2; TUMOR NECROSIS FACTOR ALPHA; CALGRANULIN A; CXCL2 PROTEIN, MOUSE; S100A8 PROTEIN, MOUSE; S100A9 PROTEIN, MOUSE; TLR2 PROTEIN, MOUSE; TLR4 PROTEIN, MOUSE; TOLL LIKE RECEPTOR 4;

ACUTE LIVER FAILURE; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALCOHOL LIVER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE SEVERITY; FIBROGENESIS; HISTOLOGY; HUMAN; LIVER INJURY; LIVER REGENERATION; MALE; MOUSE; NEUTROPHIL; NONALCOHOLIC FATTY LIVER; NONHUMAN; PRIMARY BILIARY CIRRHOSIS; PRIMARY SCLEROSING CHOLANGITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; REPERFUSION INJURY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STELLATE CELL; TOXIC HEPATITIS; WOUND HEALING; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; DEFICIENCY; DISEASE MODEL; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; NEUTROPHIL CHEMOTAXIS; PATHOLOGY;

ANIMALS; CALGRANULIN A; CALGRANULIN B; CARBON TETRACHLORIDE; CHEMOKINE CXCL2; DISEASE MODELS, ANIMAL; DRUG-INDUCED LIVER INJURY; DRUG-INDUCED LIVER INJURY, CHRONIC; HUMANS; LEUKOCYTE L1 ANTIGEN COMPLEX; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEUTROPHIL INFILTRATION; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; WOUND HEALING;

EID: 84896405331     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2013.12.005     Document Type: Article

References (32)

1. H. Jaeschke, and T. Hasegawa Role of neutrophils in acute inflammatory liver injury Liver Int 26 2006 912 919
2. H. Jaeschke, M.R. McGill, and A. Ramachandran Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity Drug Metab Rev 44 2012 88 106
3. S.K. Ramaiah, and H. Jaeschke Role of neutrophils in the pathogenesis of acute inflammatory liver injury Toxicol Pathol 35 2007 757 766
4. H. Jaeschke Neutrophil-mediated tissue injury in alcoholic hepatitis Alcohol 27 2002 23 27
5. H. Jaeschke, and B.L. Woolbright Current strategies to minimize hepatic ischemia-reperfusion injury by targeting reactive oxygen species Transplant Rev (Orlando) 26 2012 103 114
6. D. Degre, A. Lemmers, T. Gustot, R. Ouziel, E. Trepo, and P. Demetter et al. Hepatic expression of CCL2 in alcoholic liver disease is associated with disease severity and neutrophil infiltrates Clin Exp Immunol 169 2012 302 310
7. A.P. Bautista Neutrophilic infiltration in alcoholic hepatitis Alcohol 27 2002 17 21
8. H.W. Zimmermann, S. Seidler, N. Gassler, J. Nattermann, T. Luedde, and C. Trautwein et al. Interleukin-8 is activated in patients with chronic liver diseases and associated with hepatic macrophage accumulation in human liver fibrosis PLoS One 6 2011 e21381
9. J.M. Saito, M.K. Bostick, C.B. Campe, J. Xu, and J.J. Maher Infiltrating neutrophils in bile duct-ligated livers do not promote hepatic fibrosis Hepatol Res 25 2003 180 191
10. Y.W. Li, S.J. Qiu, J. Fan, J. Zhou, Q. Gao, and Y.S. Xiao et al. Intratumoral neutrophils: a poor prognostic factor for hepatocellular carcinoma following resection J Hepatol 54 2011 497 505
11. B. McDonald, and P. Kubes Neutrophils and intravascular immunity in the liver during infection and sterile inflammation Toxicol Pathol 40 2012 157 165
12. E. Seki, E. Park, and J. Fujimoto Toll-like receptor signaling in liver regeneration, fibrosis and carcinogenesis Hepatol Res 41 2011 597 610
13. C. Ryckman, K. Vandal, P. Rouleau, M. Talbot, and P.A. Tessier Proinflammatory activities of S100: proteins S100A8, S100A9, and S100A8/A9 induce neutrophil chemotaxis and adhesion J Immunol 170 2003 3233 3242
14. M.J. Lee, J.K. Lee, J.W. Choi, C.S. Lee, J.H. Sim, and C.H. Cho et al. Interleukin-6 induces S100A9 expression in colonic epithelial cells through STAT3 activation in experimental ulcerative colitis PLoS One 7 2012 e38801
15. O. Takeuchi, K. Hoshino, T. Kawai, H. Sanjo, H. Takada, and T. Ogawa et al. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components Immunity 11 1999 443 451
16. K. Hoshino, O. Takeuchi, T. Kawai, H. Sanjo, T. Ogawa, and Y. Takeda et al. Cutting edge: toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product J Immunol 162 1999 3749 3752
17. M.P. Manitz, B. Horst, S. Seeliger, A. Strey, B.V. Skryabin, and M. Gunzer et al. Loss of S100A9 (MRP14) results in reduced interleukin-8-induced CD11b surface expression, a polarized microfilament system, and diminished responsiveness to chemoattractants in vitro Mol Cell Biol 23 2003 1034 1043
18. M.R. Ebrahimkhani, F. Oakley, L.B. Murphy, J. Mann, A. Moles, and M.J. Perugorria et al. Stimulating healthy tissue regeneration by targeting the 5-HT(2)B receptor in chronic liver disease Nat Med 17 2011 1668 1673
19. Z.X. Liu, D. Han, B. Gunawan, and N. Kaplowitz Neutrophil depletion protects against murine acetaminophen hepatotoxicity Hepatology 43 2006 1220 1230
20. J. Xu, X. Zhang, M. Monestier, N.L. Esmon, and C.T. Esmon Extracellular histones are mediators of death through TLR2 and TLR4 in mouse fatal liver injury J Immunol 187 2011 2626 2631
21. Y. Saiman, and S.L. Friedman The role of chemokines in acute liver injury Front Physiol 3 2012 213
22. R.F. Schwabe, E. Seki, and D.A. Brenner Toll-like receptor signaling in the liver Gastroenterology 130 2006 1886 1900
23. K. Miura, L. Yang, N. van Rooijen, D.A. Brenner, H. Ohnishi, and E. Seki Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice Hepatology 57 2013 577 589
24. D.L. Rowell, L. Eckmann, M.B. Dwinell, S.P. Carpenter, J.L. Raucy, and S.K. Yang et al. Human hepatocytes express an array of proinflammatory cytokines after agonist stimulation or bacterial invasion Am J Physiol 273 1997 G322 G332
25. K. De Filippo, A. Dudeck, M. Hasenberg, E. Nye, N. van Rooijen, and K. Hartmann et al. Mast cell and macrophage chemokines CXCL1/CXCL2 control the early stage of neutrophil recruitment during tissue inflammation Blood 121 2013 4930 4937
26. J. Xu, G. Lee, H. Wang, J.M. Vierling, and J.J. Maher Limited role for CXC chemokines in the pathogenesis of alpha-naphthylisothiocyanate-induced liver injury Am J Physiol Gastrointest Liver Physiol 287 2004 G734 741
27. C. Gebhardt, J. Nemeth, P. Angel, and J. Hess S100A8 and S100A9 in inflammation and cancer Biochem Pharmacol 72 2006 1622 1631
28. P.E. Marques, S.S. Amaral, D.A. Pires, L.L. Nogueira, F.M. Soriani, and B.H. Lima et al. Chemokines and mitochondrial products activate neutrophils to amplify organ injury during mouse acute liver failure Hepatology 56 2012 1971 1982
29. B. McDonald, K. Pittman, G.B. Menezes, S.A. Hirota, I. Slaba, and C.C. Waterhouse et al. Intravascular danger signals guide neutrophils to sites of sterile inflammation Science 330 2010 362 366
30. M. Li, D.F. Carpio, Y. Zheng, P. Bruzzo, V. Singh, and F. Ouaaz et al. An essential role of the NF-kappa B/Toll-like receptor pathway in induction of inflammatory and tissue-repair gene expression by necrotic cells J Immunol 166 2001 7128 7135
31. E. Seki, S. De Minicis, C.H. Osterreicher, J. Kluwe, Y. Osawa, and D.A. Brenner et al. TLR4 enhances TGF-beta signaling and hepatic fibrosis Nat Med 13 2007 1324 1332
32. P. Hartmann, M. Haimerl, M. Mazagova, D.A. Brenner, and B. Schnabl Toll-like receptor 2-mediated intestinal injury and enteric tumor necrosis factor receptor I contribute to liver fibrosis in mice Gastroenterology 143 2012 1330 1340 e1331