NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice

Hepatology

Volumn 59, Issue 3, 2014, Pages 898-910

  Wree, Alexander ^a,b   Eguchi, Akiko ^a   Mcgeough, Matthew D ^a   Pena, Carla A ^a   Johnson, Casey D ^a   Canbay, Ali ^b   Hoffman, Hal M ^a,c   Feldstein, Ariel E ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY HOSPITAL ESSEN   (Germany)

^c RADY CHILDREN'S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1BETA CONVERTING ENZYME; MUTANT PROTEIN; NLRP3 INFLAMMASOME; PROPIDIUM IODIDE; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CELL ACTIVATION; CELL DEATH; CELL GROWTH; CELL SEPARATION; CELL SURVIVAL; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME ACTIVITY; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; GENE ACTIVATION; GENE EXPRESSION; GENE TARGETING; GENETIC ANALYSIS; GROWTH RETARDATION; HEPATITIS; HISTOPATHOLOGY; IN VIVO STUDY; LIVER CELL; LIVER FIBROSIS; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PHENOTYPE; POINT MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PYROPTOSIS; QUANTITATIVE ANALYSIS; STELLATE CELL;

ANIMALS; ANTIRHEUMATIC AGENTS; APOPTOSIS; CARRIER PROTEINS; DISEASE MODELS, ANIMAL; GROWTH DISORDERS; HEPATIC STELLATE CELLS; HEPATITIS; HEPATOCYTES; HUMANS; INFLAMMASOMES; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; LIVER CIRRHOSIS; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; NEUTROPHILS; POINT MUTATION; RECEPTORS, INTERLEUKIN-1;

EID: 84896709837     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.26592     Document Type: Article

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