Complete differentiation of CD8+ T cells activated locally within the transplanted liver

Journal of Experimental Medicine

Volumn 203, Issue 2, 2006, Pages 437-447

  Klein, Ingo ^a,b   Crispe, Ian Nicholas ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; BONE MARROW TRANSPLANTATION; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; EXPERIMENTAL MODEL; FLOW CYTOMETRY; FUNCTIONAL ASSESSMENT; IMMUNOLOGICAL TOLERANCE; LIVER; LIVER TRANSPLANTATION; LYMPHOCYTE DIFFERENTIATION; MICROCHIMERISM; MOUSE; NONHUMAN; ORGAN DONOR; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

ADOPTIVE TRANSFER; ANIMALS; ANTIGEN PRESENTATION; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL MOVEMENT; CELL PROLIFERATION; CELLS, CULTURED; CYTOTOXICITY TESTS, IMMUNOLOGIC; G0 PHASE; INTERFERON TYPE II; LEUKOCYTES; LIVER; LIVER TRANSPLANTATION; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MICE, TRANSGENIC; ORGAN CULTURE TECHNIQUES; RADIATION CHIMERA;

EID: 33344467532     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20051775     Document Type: Article

References (48)

1. Rehermann, B., and M. Nascimbeni. 2005. Immunology of hepatitis B virus and hepatitis C virus infection. Nat. Rev. Immunol. 5:215-229.
2. Good, M.F. 1995. Development of immunity to malaria may not be an entirely active process. Parasite Immunol. 17:55-59.
3. Calne, R., and H. Davies. 1994. Organ graft tolerance: the liver effect. Lancet. 343:67-68.
4. Gassel, H.J., I.V. Hutchinson, R. Engemann, and P.J. Morris. 1992. The role of T suppressor cells in the maintenance of spontaneously accepted orthotopic rat liver allografts. Transplantation. 54:1048-1053.
5. Farges, O., P.J. Morris, and M.J. Dallman. 1994. Spontaneous acceptance of liver allografts in the rat. Analysis of the immune response. Transplantation. 57:171-177.
6. Dahmen, U., S. Qian, A.S. Rao, A.J. Demetris, F. Fu, H. Sun, L. Gao, J.J. Fung, and T.E. Starzl. 1994. Split tolerance induced by orthotopic liver transplantation in mice. Transplantation. 58:1-8.
7. Qian, S., L. Lu, F. Fu, Y. Li, W. Li, T.E. Starzl, J.J. Fung, and A.W. Thomson. 1997. Apoptosis within spontaneously accepted mouse liver allografts: evidence for deletion of cytotoxic T cells and implications for tolerance induction. J. Immunol. 158:4654-4661.
8. Calne, R.Y. 2000. Immunological tolerance-the liver effect. Immunol. Rev. 174:280-282.
9. Mazariegos, G.V., J. Reyes, I.R. Marino, A.J. Demetris, B. Flynn, W. Irish, J. McMichael, J.J. Fung, and T.E. Starzl. 1997. Weaning of immunosuppression in liver transplant recipients. Transplantation. 63:243-249.
10. Mowat, A.M., L.A. Parker, H. Beacock-Sharp, O.R. Millington, and F. Chirdo. 2004. Oral tolerance: overview and historical perspectives. Ann. N Y Acad. Sci. 1029:1-8.
11. Gorczynski, R.M., Z. Chen, H. Zeng, and X.M. Fu. 1998. A role for persisting antigen, antigen presentation, and ICAM-1 in increased renal graft survival after oral or portal vein donor-specific immunization. Transplantation. 66:339-349.
12. Knolle, P.A., and G. Gerken. 2000. Local control of the immune response in the liver. Immunol. Rev. 174:21-34.
13. Yang, R., Q. Liu, J.L. Grosfeld, and M.D. Pescovitz. 1994. Intestinal venous drainage through the liver is a prerequisite for oral tolerance induction. J. Pediatr. Surg. 29:1145-1148.
14. Crispe, I.N. 2003. Hepatic T cells and liver tolerance. Nat. Rev. Immunol. 3:51-62.
15. Czaja, A.J. 2001. Understanding the pathogenesis of autoimmune hepatitis. Am. J. Gastroenterol. 96:1224-1231.
16. Limmer, A., J. Ohl, C. Kurts, H.G. Ljunggren, Y. Reiss, M. Groettrup, F. Momburg, B. Arnold, and P.A. Knolle. 2000. Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance. Nat. Med. 6:1348-1354.
17. Bertolino, P., M.C. Trescol-Biemont, J. Thomas, B. Fazekas de St Groth, M. Pihlgren, J. Marvel, and C. Rabourdin-Combe. 1999. Death by neglect as a deletional mechanism of peripheral tolerance. Int. Immunol. 11:1225-1238.
18. Bertolino, P., D.G. Bowen, G.W. McCaughan, and B. Fazekas de St Groth. 2001. Antigen-specific primary activation of CD8+ T cells within the liver. J. Immunol. 166:5430-5438.
19. Bowen, D.G., M. Zen, L. Holz, T. Davis, G.W. McCaughan, and P. Bertolino. 2004. The site of primary T cell activation is a determinant of the balance between intrahepatic tolerance and immunity. J. Clin. Invest. 114:701-712.
20. Apostolou, I., A. Sarukhan, L. Klein, and H. von Boehmer. 2002. Origin of regulatory T cells with known specificity for antigen. Nat. Immunol. 3:756-763.
21. Su, M.A., and M.S. Anderson. 2004. Aire: an update. Curr. Opin. Immunol. 16:746-752.
22. Lohse, A.W., P.A. Knolle, K. Bilo, A. Uhrig, C. Waldmann, M. Ibe, E. Schmitt, G. Gerken, and K.H. Meyer Zum Buschenfelde. 1996. Antigen-presenting function and B7 expression of murine sinusoidal endothelial cells and Kupffer cells. Gastroenterology. 110:1175-1181.
23. Bertolino, P., M.C. Trescol-Biemont, and C. Rabourdin-Combe. 1998. Hepatocytes induce functional activation of naive CD8+ T lymphocytes but fail to promote survival. Eur. J. Immunol. 28:221-236.
24. Nikolic-Zugic, J., and F.R. Carbone. 1990. The effect of mutations in the MHC class I peptide binding groove on the cytotoxic T lymphocyte recognition of the Kb-restricted ovalbumin determinant. Eur. J. Immunol. 20:2431-2437.
25. Bettens, F., J.M. Tiercy, N. Campanile, E. Giostra, P. Majno, L. Rubbia, E. Roosnek, G. Mentha, and J. Villard. 2005. Microchimerism after liver transplantation: absence of rejection without abrogation of anti-donor cytotoxic T-lymphocyte-mediated alloreactivity. Liver Transpl. 11:290-297.
26. Rao, A.S., A.W. Thomson, R. Shapiro, and T.E. Starzl. 1994. Chimerism after whole organ transplantation: its relationship to graft rejection and tolerance induction. Curr. Opin. Nephrol. Hypertens. 3:589-595.
27. Lau, A.H., and A.W. Thomson. 2003. Dendritic cells and immune regulation in the liver. Gut. 52:307-314.
28. Mehal, W.Z., A.E. Juedes, and I.N. Crispe. 1999. Selective retention of activated CD8+ T cells by the normal liver. J. Immunol. 163:3202-3210.
29. Mehal, W.Z., F. Azzaroli, and I.N. Crispe. 2001. Antigen presentation by liver cells controls intrahepatic T cell trapping, whereas bone marrow-derived cells preferentially promote intrahepatic T cell apoptosis. J. Immunol. 167:667-673.
30. Itano, A.A., and M.K. Jenkins. 2003. Antigen presentation to naive CD4 T cells in the lymph node. Nat. Immunol. 4:733-739.
31. Shahinian, A., K. Pfeffer, K.P. Lee, T.M. Kundig, K. Kishihara, A. Wakeham, K. Kawai, P.S. Ohashi, C.B. Thompson, and T.W. Mak. 1993. Differential T cell costimulatory requirements in CD28-deficient mice. Science. 261:609-612.
32. Lenschow, D.J., K.C. Herold, L. Rhee, B. Patel, A. Koons, H.Y. Qin, E. Fuchs, B. Singh, C.B. Thompson, and J.A. Bluestone. 1996. CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes. Immunity. 5:285-293.
33. Wang, B., R. Maile, R. Greenwood, E.J. Collins, and J.A. Frelinger. 2000. Naive CD8+ T cells do not require costimulation for proliferation and differentiation into cytotoxic effector cells. J. Immunol. 164:1216-1222.
34. Qian, S., A.J. Demetris, N. Murase, A.S. Rao, J.J. Fung, and T.E. Starzl. 1994. Murine liver allograft transplantation: tolerance and donor cell chimerism. Hepatology. 19:916-924.
35. Starzl, T.E. 2004. Chimerism and tolerance in transplantation. Proc. Natl. Acad. Sci. USA. 101:14607-14614.
36. Wood, K.J. 2003. Passenger leukocytes and microchimerism: what role in tolerance induction? Transplantation. 75:17S-20S.
37. van Oosten, M., E. van de Bilt, H.E. de Vries, T.J. van Berkel, and J. Kuiper. 1995. Vascular adhesion molecule-1 and intercellular adhesion molecule-1 expression on rat liver cells after lipopolysaccharide administration in vivo. Hepatology. 22:1538-1546.
38. Knolle, P.A., and A. Limmer. 2001. Neighborhood politics: the immunoregulatory function of organ-resident liver endothelial cells. Trends Immunol. 22:432-437.
39. Bertolino, P., G.W. McCaughan, and D.G. Bowen. 2002. Role of primary intrahepatic T-cell activation in the 'liver tolerance effect'. Immunol. Cell Biol. 80:84-92.
40. Knolle, P.A., E. Schmitt, S. Jin, T. Germann, R. Duchmann, S. Hegenbarth, G. Gerken, and A.W. Lohse. 1999. Induction of cytokine production in naive CD4(+) T cells by antigen-presenting murine liver sinusoidal endothelial cells but failure to induce differentiation toward Th1 cells. Gastroenterology. 116:1428-1440.
41. Katz, S.C., V.G. Pillarisetty, J.I. Bleier, A.B. Shah, and R.P. DeMatteo. 2004. Liver sinusoidal endothelial cells are insufficient to activate T cells. J. Immunol. 173:230-235.
42. Jolicoeur, C., D. Hanahan, and K.M. Smith. 1994. T-cell tolerance toward a transgenic beta-cell antigen and transcription of endogenous pancreatic genes in thymus. Proc. Natl. Acad. Sci. USA. 91:6707-6711.
43. Jordan, M.S., A. Boesteanu, A.J. Reed, A.L. Petrone, A.E. Holenbeck, M.A. Lerman, A. Naji, and A.J. Caton. 2001. Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide. Nat. Immunol. 2:301-306.
44. von Boehmer, H., I. Aifantis, F. Gounari, O. Azogui, L. Haughn, I. Apostolou, E. Jaeckel, F. Grassi, and L. Klein. 2003. Thymic selection revisited: how essential is it? Immunol. Rev. 191:62-78.
45. Racanelli, V., and B. Rehermann. 2003. Hepatitis C virus infection: when silence is deception. Trends Immunol. 24:456-464.
46. Qian, S.G., J.J. Fung, A.V. Demetris, S.T. Ildstad, and T.E. Starzl. 1991. Orthotopic liver transplantation in the mouse. Transplantation. 52:562-564.
47. Steger, U., B. Sawitzki, A.M. Gassel, H.J. Gassel, and K.J. Wood. 2003. Impact of hepatic rearterialization on reperfusion injury and outcome after mouse liver transplantation. Transplantation. 76:327-332.
48. John, B., and I.N. Crispe. 2004. Passive and active mechanisms trap activated CD8+ T cells in the liver. J. Immunol. 172:5222-5229.