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Volumn 58, Issue 5, 2009, Pages 704-720

Toll-like receptors as targets in chronic liver diseases

Author keywords

[No Author keywords available]

Indexed keywords

6 [N (2 CHLORO 4 FLUOROPHENYL)SULFAMOYL] 1 CYCLOHEXENE 1 CARBOXYLIC ACID ETHYL ESTER; ALPHA2B INTERFERON; ANA 975; CPG 10101; CRX 526; ERITORAN; HYALURONIC ACID; ISATORIBINE; LIGAND; PROBIOTIC AGENT; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG;

EID: 66349110620     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gut.2008.156307     Document Type: Review
Times cited : (301)

References (197)
  • 1
    • 0034680145 scopus 로고    scopus 로고
    • Toll-like receptors in the induction of the innate immune response
    • Aderem A, Ulevitch RJ. Toll-like receptors in the induction of the innate immune response. Nature 2000:406:782-7.
    • (2000) Nature , vol.406 , pp. 782-787
    • Aderem, A.1    Ulevitch, R.J.2
  • 3
    • 0030595339 scopus 로고    scopus 로고
    • The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults
    • Lemaitre B, Nicolas E, Michaut L, et al. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 1996:86:973-83.
    • (1996) Cell , vol.86 , pp. 973-983
    • Lemaitre, B.1    Nicolas, E.2    Michaut, L.3
  • 4
    • 22144452520 scopus 로고    scopus 로고
    • The evolution of vertebrate Toll-like receptors
    • Roach JC, Glusman G, Rowen L, et al. The evolution of vertebrate Toll-like receptors. Proc Natl Acad Sci USA 2005:102:9577-82.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 9577-9582
    • Roach, J.C.1    Glusman, G.2    Rowen, L.3
  • 5
    • 61849170035 scopus 로고    scopus 로고
    • TLRs and innate immunity
    • Beutler BA. TLRs and innate immunity. Blood 2009:113:1399-407.
    • (2009) Blood , vol.113 , pp. 1399-1407
    • Beutler, B.A.1
  • 6
    • 27844541797 scopus 로고    scopus 로고
    • Control of B-cell responses by Toll-like receptors
    • Pasare C, Medzhitov R. Control of B-cell responses by Toll-like receptors. Nature 2005:438:364-8.
    • (2005) Nature , vol.438 , pp. 364-368
    • Pasare, C.1    Medzhitov, R.2
  • 7
    • 58549089483 scopus 로고    scopus 로고
    • Toll-like receptors and wound healing
    • Kluwe J, Mencin A, Schwabe RF. Toll-like receptors and wound healing. J Mol Med 2009:87:125-38.
    • (2009) J Mol Med , vol.87 , pp. 125-138
    • Kluwe, J.1    Mencin, A.2    Schwabe, R.F.3
  • 9
    • 33747040825 scopus 로고    scopus 로고
    • Pattern recognition receptors: A contemporary view on liver diseases
    • Szabo G, Dolganiuc A, Mandrekar P. Pattern recognition receptors: a contemporary view on liver diseases. Hepatology 2006:44:287-98.
    • (2006) Hepatology , vol.44 , pp. 287-298
    • Szabo, G.1    Dolganiuc, A.2    Mandrekar, P.3
  • 10
    • 47149105036 scopus 로고    scopus 로고
    • Toll-like receptors and adaptor molecules in liver disease: Update
    • Seki E, Brenner DA. Toll-like receptors and adaptor molecules in liver disease: update. Hepatology 2008:48:322-35.
    • (2008) Hepatology , vol.48 , pp. 322-335
    • Seki, E.1    Brenner, D.A.2
  • 11
    • 3142724031 scopus 로고    scopus 로고
    • Toll-like receptor signalling
    • Akira S, Takeda K. Toll-like receptor signalling. Nat Rev Immunol 2004:4:499-511.
    • (2004) Nat Rev Immunol , vol.4 , pp. 499-511
    • Akira, S.1    Takeda, K.2
  • 12
    • 32944464648 scopus 로고    scopus 로고
    • Pathogen recognition and innate immunity
    • Akira S, Uematsu S, Takeuchi 0. Pathogen recognition and innate immunity. Cell 2006:124:783-801.
    • (2006) Cell , vol.124 , pp. 783-801
    • Akira, S.1    Uematsu, S.2    Takeuchi 03
  • 14
    • 20644469429 scopus 로고    scopus 로고
    • CD14 is required for MyD88-independent LPS signaling
    • Jiang Z, Georgel P, Du X, et al. CD14 is required for MyD88-independent LPS signaling. Nat Immunol 2005:6:565-70.
    • (2005) Nat Immunol , vol.6 , pp. 565-570
    • Jiang, Z.1    Georgel, P.2    Du, X.3
  • 15
    • 0036301797 scopus 로고    scopus 로고
    • Essential role of MD-2 in LPS responsiveness and TLR4 distribution
    • Nagai Y, Akashi S, Nagafuku M, et al. Essential role of MD-2 in LPS responsiveness and TLR4 distribution. Nat Immunol 2002:3:667-72.
    • (2002) Nat Immunol , vol.3 , pp. 667-672
    • Nagai, Y.1    Akashi, S.2    Nagafuku, M.3
  • 16
    • 0035796406 scopus 로고    scopus 로고
    • Molecular genetic analysis of an endotoxin nonresponder mutant cell line: A point mutation in a conserved region of MD-2 abolishes endotoxin-induced signaling
    • Schromm AB, Lien E, Henneke P, et al. Molecular genetic analysis of an endotoxin nonresponder mutant cell line: a point mutation in a conserved region of MD-2 abolishes endotoxin-induced signaling. J Exp Med 2001:194:79-88.
    • (2001) J Exp Med , vol.194 , pp. 79-88
    • Schromm, A.B.1    Lien, E.2    Henneke, P.3
  • 17
    • 34548222514 scopus 로고    scopus 로고
    • Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran
    • Kim HM, Park BS, Kim Jl, et al. Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran. Cell 2007:130:906-17.
    • (2007) Cell , vol.130 , pp. 906-917
    • Kim, H.M.1    Park, B.S.2    Kim, J.3
  • 18
    • 13444280215 scopus 로고    scopus 로고
    • CD36 is a sensor of diacylglycerides
    • Hoebe K, Georgel P, Rutschmann S, et al. CD36 is a sensor of diacylglycerides. Nature 2005:433:523-7.
    • (2005) Nature , vol.433 , pp. 523-527
    • Hoebe, K.1    Georgel, P.2    Rutschmann, S.3
  • 19
    • 20644450804 scopus 로고    scopus 로고
    • Negative regulation of toll-like receptor-mediated immune responses
    • Liew FY, Xu D, Brint EK, et al. Negative regulation of toll-like receptor-mediated immune responses. Nat Rev Immunol 2005:5:446-58.
    • (2005) Nat Rev Immunol , vol.5 , pp. 446-458
    • Liew, F.Y.1    Xu, D.2    Brint, E.K.3
  • 20
    • 20244384395 scopus 로고    scopus 로고
    • Cutting edge: Endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface toll-like receptor 4 expression
    • Nomura F, Akashi S, Sakao Y, et al. Cutting edge: endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface toll-like receptor 4 expression. J Immunol 2000:164:3476- 9.
    • (2000) J Immunol , vol.164 , pp. 3476-3479
    • Nomura, F.1    Akashi, S.2    Sakao, Y.3
  • 21
    • 2442643942 scopus 로고    scopus 로고
    • Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors
    • Chuang TH, Ulevitch RJ. Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors. Nat Immunol 2004:5:495-502.
    • (2004) Nat Immunol , vol.5 , pp. 495-502
    • Chuang, T.H.1    Ulevitch, R.J.2
  • 22
    • 31344467156 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mai degradation
    • Mansell A, Smith R, Doyle SL, et al. Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mai degradation. Nat Immunol 2006:7:148-55.
    • (2006) Nat Immunol , vol.7 , pp. 148-155
    • Mansell, A.1    Smith, R.2    Doyle, S.L.3
  • 23
    • 2942721674 scopus 로고    scopus 로고
    • ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance
    • Brint EK Xu D, Liu H, et al. ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance. Nat Immunol 2004:5:373-9.
    • (2004) Nat Immunol , vol.5 , pp. 373-379
    • Brint, E.K.1    Xu, D.2    Liu, H.3
  • 24
    • 0042733592 scopus 로고    scopus 로고
    • SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling
    • Wald D, Qin J, Zhao Z, et al. SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling. Nat Immunol 2003:4:920-7.
    • (2003) Nat Immunol , vol.4 , pp. 920-927
    • Wald, D.1    Qin, J.2    Zhao, Z.3
  • 25
    • 20644450101 scopus 로고    scopus 로고
    • Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105
    • Divanovic S, Trompette A, Atabani SF, et al. Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105. Nat Immunol 2005:6:571-8.
    • (2005) Nat Immunol , vol.6 , pp. 571-578
    • Divanovic, S.1    Trompette, A.2    Atabani, S.F.3
  • 26
    • 0042236366 scopus 로고    scopus 로고
    • MyD88S, a splice variant of MyD88, differentially modulates NF-kappaB- and AP-1-dependent gene expression
    • Janssens S, Burns K, Vercammen E, et al. MyD88S, a splice variant of MyD88, differentially modulates NF-kappaB- and AP-1-dependent gene expression. FEBS Lett 2003:548:103-7.
    • (2003) FEBS Lett , vol.548 , pp. 103-107
    • Janssens, S.1    Burns, K.2    Vercammen, E.3
  • 27
    • 0037454946 scopus 로고    scopus 로고
    • Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4
    • Burns K, Janssens S, Brissoni B, et al. Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4. J Exp Med 2003:197:263-8.
    • (2003) J Exp Med , vol.197 , pp. 263-268
    • Burns, K.1    Janssens, S.2    Brissoni, B.3
  • 28
    • 0037178785 scopus 로고    scopus 로고
    • IRAK-M is a negative regulator of Toll-like receptor signaling
    • Kobayashi K, Hernandez LD, Galan JE, et al. IRAK-M is a negative regulator of Toll-like receptor signaling. Cell 2002:110:191-202.
    • (2002) Cell , vol.110 , pp. 191-202
    • Kobayashi, K.1    Hernandez, L.D.2    Galan, J.E.3
  • 29
    • 3042686382 scopus 로고    scopus 로고
    • The murine IRAK2 gene encodes four alternatively spliced isoforms, two of which are inhibitory
    • Hardy MP, O'Neill LA. The murine IRAK2 gene encodes four alternatively spliced isoforms, two of which are inhibitory. J Biol Chem 2004:279:27699-708.
    • (2004) J Biol Chem , vol.279 , pp. 27699-27708
    • Hardy, M.P.1    O'Neill, L.A.2
  • 30
    • 14244252178 scopus 로고    scopus 로고
    • Bacterial translocation (BT) in cirrhosis
    • Wiest R, Garcia-Tsao G. Bacterial translocation (BT) in cirrhosis. Hepatology 2005:41:422-33.
    • (2005) Hepatology , vol.41 , pp. 422-433
    • Wiest, R.1    Garcia-Tsao, G.2
  • 31
    • 0026078067 scopus 로고
    • Plasma endotoxin concentrations in patients with alcoholic and non-alcoholic liver disease: Reevaluation with an improved chromogenic assay
    • Fukui H, Brauner B, Bode JC, et al. Plasma endotoxin concentrations in patients with alcoholic and non-alcoholic liver disease: reevaluation with an improved chromogenic assay. JHepatol 1991:12:162-9.
    • (1991) JHepatol , vol.12 , pp. 162-169
    • Fukui, H.1    Brauner, B.2    Bode, J.C.3
  • 32
    • 0342699553 scopus 로고    scopus 로고
    • Increased intestinal permeability to macromolecules and endotoxemia in patients with chronic alcohol abuse in different stages of alcohol-induced liver disease
    • Parlesak A, Schafer C, Schutz T, et al. Increased intestinal permeability to macromolecules and endotoxemia in patients with chronic alcohol abuse in different stages of alcohol-induced liver disease. J Hepatol 2000:32:742-7.
    • (2000) J Hepatol , vol.32 , pp. 742-747
    • Parlesak, A.1    Schafer, C.2    Schutz, T.3
  • 33
    • 0033765501 scopus 로고    scopus 로고
    • Exacerbation of alcoholic liver injury by enteral endotoxin in rats
    • Mathurin P, Deng QG, Keshavarzian A, et al. Exacerbation of alcoholic liver injury by enteral endotoxin in rats. Hepatology 2000:32:1008-17.
    • (2000) Hepatology , vol.32 , pp. 1008-1017
    • Mathurin, P.1    Deng, Q.G.2    Keshavarzian, A.3
  • 34
    • 0021328175 scopus 로고
    • Intestinal flora in health and disease
    • Simon GL Gorbach SL. Intestinal flora in health and disease. Gastroenterology 1984:86:174-93.
    • (1984) Gastroenterology , vol.86 , pp. 174-193
    • Simon, G.L.1    Gorbach, S.L.2
  • 35
    • 0023627544 scopus 로고
    • Role of anaerobic flora in the translocation of aerobic and facultatively anaerobic intestinal bacteria
    • Wells CL, Maddaus MA, Reynolds CM, et al. Role of anaerobic flora in the translocation of aerobic and facultatively anaerobic intestinal bacteria. Infect Immun 1987:55:2689-94.
    • (1987) Infect Immun , vol.55 , pp. 2689-2694
    • Wells, C.L.1    Maddaus, M.A.2    Reynolds, C.M.3
  • 36
    • 0023896026 scopus 로고
    • Comparison of translocation rates of various indigenous bacteria from the gastrointestinal tract to the mesenteric lymph node
    • Steffen EK, Berg RD, Deitch EA. Comparison of translocation rates of various indigenous bacteria from the gastrointestinal tract to the mesenteric lymph node. J Infect Dis 1988:157:1032-8.
    • (1988) J Infect Dis , vol.157 , pp. 1032-1038
    • Steffen, E.K.1    Berg, R.D.2    Deitch, E.A.3
  • 37
    • 40149099357 scopus 로고    scopus 로고
    • Bacterial infections, sepsis, and multiorgan failure in cirrhosis
    • Tandon P, Garcia-Tsao G. Bacterial infections, sepsis, and multiorgan failure in cirrhosis. Semin Liver Dis 2008:28:26-42.
    • (2008) Semin Liver Dis , vol.28 , pp. 26-42
    • Tandon, P.1    Garcia-Tsao, G.2
  • 38
    • 35748950109 scopus 로고    scopus 로고
    • Neo-ligands for innate immune receptors and the etiology of sterile inflammatory disease
    • Beutler B. Neo-ligands for innate immune receptors and the etiology of sterile inflammatory disease. Immunol Rev 2007:220:113-28.
    • (2007) Immunol Rev , vol.220 , pp. 113-128
    • Beutler, B.1
  • 39
    • 34247577195 scopus 로고    scopus 로고
    • Vesicular stomatitis virus glycoprotein G activates a specific antiviral Toll-like receptor 4-dependent pathway
    • Georgel P, Jiang Z, Kunz S, et al. Vesicular stomatitis virus glycoprotein G activates a specific antiviral Toll-like receptor 4-dependent pathway. Virology 2007:362:304-13.
    • (2007) Virology , vol.362 , pp. 304-313
    • Georgel, P.1    Jiang, Z.2    Kunz, S.3
  • 40
    • 0037502208 scopus 로고    scopus 로고
    • Subversion of the innate immune system by a retrovirus
    • Jude BA, Pobezinskaya Y, Bishop J, et al. Subversion of the innate immune system by a retrovirus. Nat Immunol 2003:4:573-8.
    • (2003) Nat Immunol , vol.4 , pp. 573-578
    • Jude, B.A.1    Pobezinskaya, Y.2    Bishop, J.3
  • 41
    • 5944261457 scopus 로고    scopus 로고
    • Pattern recognition receptors TLR4 and CD 14 mediate response to respiratory syncytial virus
    • Kurt-Jones EA, Popova L, Kwinn L, et al. Pattern recognition receptors TLR4 and CD 14 mediate response to respiratory syncytial virus. Nat Immunol 2000:1:398-401.
    • (2000) Nat Immunol , vol.1 , pp. 398-401
    • Kurt-Jones, E.A.1    Popova, L.2    Kwinn, L.3
  • 42
    • 35748945719 scopus 로고    scopus 로고
    • The grateful dead: Damage-associated molecular pattern molecules and reduction/ oxidation regulate immunity
    • Lotze MT, Zeh HJ, Rubartelli A, et al. The grateful dead: damage-associated molecular pattern molecules and reduction/ oxidation regulate immunity. Immunol Rev 2007:220:60-81.
    • (2007) Immunol Rev , vol.220 , pp. 60-81
    • Lotze, M.T.1    Zeh, H.J.2    Rubartelli, A.3
  • 43
    • 34547116858 scopus 로고    scopus 로고
    • Pathogen-associated molecular pattern contamination as putative endogenous ligands of Toll-like receptors
    • Tsan MF, Baochong G. Pathogen-associated molecular pattern contamination as putative endogenous ligands of Toll-like receptors. J Endotoxin Res 2007:13:6-14.
    • (2007) J Endotoxin Res , vol.13 , pp. 6-14
    • Tsan, M.F.1    Baochong, G.2
  • 44
    • 1542380035 scopus 로고    scopus 로고
    • Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein
    • Park JS, Svetkauskaite D, He Q, et al. Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein. J Biol Chem 2004:279:7370-7.
    • (2004) J Biol Chem , vol.279 , pp. 7370-7377
    • Park, J.S.1    Svetkauskaite, D.2    He, Q.3
  • 45
    • 30744462300 scopus 로고    scopus 로고
    • Regulation of lung injury and repair by Toll-like receptors and hyaluronan
    • Jiang D, Liang J, Fan J, et al. Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nat Med 2005:11:1173-9.
    • (2005) Nat Med , vol.11 , pp. 1173-1179
    • Jiang, D.1    Liang, J.2    Fan, J.3
  • 46
    • 20244373939 scopus 로고    scopus 로고
    • The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion
    • Tsung A, Sahai R, Tanaka H, et al. The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion. J Exp Med 2005:201:1135-43.
    • (2005) J Exp Med , vol.201 , pp. 1135-1143
    • Tsung, A.1    Sahai, R.2    Tanaka, H.3
  • 47
    • 35948958955 scopus 로고    scopus 로고
    • TLR4 enhances TGF-beta signaling and hepatic fbrosis
    • Seki E, De Minicis S, Osterreicher CH, et al. TLR4 enhances TGF-beta signaling and hepatic fbrosis. Nat Med 2007:13:1324-32.
    • (2007) Nat Med , vol.13 , pp. 1324-1332
    • Seki, E.1    De Minicis, S.2    Osterreicher, C.H.3
  • 48
    • 66449091696 scopus 로고    scopus 로고
    • High-mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity
    • Bianchi ME, Manfredi AA. High-mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity. Immunol Rev 2005;5:331-42.
    • (2005) Immunol Rev , vol.5 , pp. 331-342
    • Bianchi, M.E.1    Manfredi, A.A.2
  • 49
    • 17144376810 scopus 로고    scopus 로고
    • High-mobility group box 1 protein (HMGB1): Nuclear weapon in the immune arsenal
    • Lotze MT, Tracey KJ. High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal. Nat Rev Immunol 2005:5:331-42.
    • (2005) Nat Rev Immunol , vol.5 , pp. 331-342
    • Lotze, M.T.1    Tracey, K.J.2
  • 50
    • 0142137129 scopus 로고    scopus 로고
    • Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion
    • Bonaldi T, Talamo F, Scaffidi P, et al. Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion. EMBO J 2003:22:5551-60.
    • (2003) EMBO J , vol.22 , pp. 5551-5560
    • Bonaldi, T.1    Talamo, F.2    Scaffidi, P.3
  • 51
    • 0037062934 scopus 로고    scopus 로고
    • Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
    • Scaffidi P, Misteli T, Bianchi ME. Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 2002:418:191-5.
    • (2002) Nature , vol.418 , pp. 191-195
    • Scaffidi, P.1    Misteli, T.2    Bianchi, M.E.3
  • 53
    • 0018574122 scopus 로고
    • The clearance, tissue distribution, and cellular localization of intravenously injected lipopolysaccharide in rabbits
    • Mathison JC, Ulevitch RJ. The clearance, tissue distribution, and cellular localization of intravenously injected lipopolysaccharide in rabbits. J Immunol 1979:123:2133-43.
    • (1979) J Immunol , vol.123 , pp. 2133-2143
    • Mathison, J.C.1    Ulevitch, R.J.2
  • 54
    • 0019394237 scopus 로고
    • Uptake by liver cells of endotoxin following its intravenous injection
    • Ruiter DJ, van der Meulen J, Brouwer A, et al. Uptake by liver cells of endotoxin following its intravenous injection. Lab Invest 1981:45:38-45.
    • (1981) Lab Invest , vol.45 , pp. 38-45
    • Ruiter, D.J.1    van der Meulen, J.2    Brouwer, A.3
  • 55
    • 84961040091 scopus 로고
    • A quantitative study of the kinetics of blood clearance of P32-labelled Escherichia coli and Staphylococci by the reticuloendothelial system
    • Benacerraf B, Sebestyen MM, Schlossman S. A quantitative study of the kinetics of blood clearance of P32-labelled Escherichia coli and Staphylococci by the reticuloendothelial system. J Exp Med 1959:110:27-48.
    • (1959) J Exp Med , vol.110 , pp. 27-48
    • Benacerraf, B.1    Sebestyen, M.M.2    Schlossman, S.3
  • 56
    • 0033625773 scopus 로고    scopus 로고
    • FcalphaRI-positive liver Kupffer cells: Reappraisal of the function of immunoglobulin A in immunity
    • van Egmond M, van Garderen E, van Spriel AB, et al. FcalphaRI-positive liver Kupffer cells: reappraisal of the function of immunoglobulin A in immunity. Nat Med 2000:6:680-5.
    • (2000) Nat Med , vol.6 , pp. 680-685
    • van Egmond, M.1    van Garderen, E.2    van Spriel, A.B.3
  • 57
    • 13544263583 scopus 로고    scopus 로고
    • Low TLR4 Expression by liver dendritic cells correlates with reduced capacity to activate allogeneic T cells in response to endotoxin
    • De Creus A, Abe M, Lau AH, et al. Low TLR4 Expression by liver dendritic cells correlates with reduced capacity to activate allogeneic T cells in response to endotoxin. J Immunol 2005:174:2037-45.
    • (2005) J Immunol , vol.174 , pp. 2037-2045
    • De Creus, A.1    Abe, M.2    Lau, A.H.3
  • 58
    • 0031859333 scopus 로고    scopus 로고
    • LPS receptor CD14 participates in release of TNF-alpha in RAW 264.7 and peritoneal cells but not in kupffer cells
    • Lichtman SN, Wang J, Lemasters JJ. LPS receptor CD14 participates in release of TNF-alpha in RAW 264.7 and peritoneal cells but not in kupffer cells. Am J Physiol 1998;275:G39-46.
    • (1998) Am J Physiol , vol.275
    • Lichtman, S.N.1    Wang, J.2    Lemasters, J.J.3
  • 59
    • 0037080024 scopus 로고    scopus 로고
    • Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines
    • Zarember KA, Godowski PJ. Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines. J Immunol 2002:168:554-61.
    • (2002) J Immunol , vol.168 , pp. 554-561
    • Zarember, K.A.1    Godowski, P.J.2
  • 60
    • 33750999322 scopus 로고    scopus 로고
    • Role of Kupffer cells in host defense and liver disease
    • Bilzer M, Roggel F, Gerbes AL. Role of Kupffer cells in host defense and liver disease. Liver Int 2006:26:1175-86.
    • (2006) Liver Int , vol.26 , pp. 1175-1186
    • Bilzer, M.1    Roggel, F.2    Gerbes, A.L.3
  • 61
    • 0034070414 scopus 로고    scopus 로고
    • Kupffer cell activation by lipopolysaccharide in rats: Role for lipopolysaccharide binding protein and toll-like receptor 4
    • Su GL, Klein RD, Aminlari A, et al. Kupffer cell activation by lipopolysaccharide in rats: role for lipopolysaccharide binding protein and toll-like receptor 4. Hepatology 2000:31:932-6.
    • (2000) Hepatology , vol.31 , pp. 932-936
    • Su, G.L.1    Klein, R.D.2    Aminlari, A.3
  • 62
    • 0024207738 scopus 로고
    • Cellular and subcellular distribution of injected lipopolysaccharide in rat liver and its inactivation by bile salts
    • Van Bossuyt H, De Zanger RB, Wisse E. Cellular and subcellular distribution of injected lipopolysaccharide in rat liver and its inactivation by bile salts. J Hepatol 1988:7:325-37.
    • (1988) J Hepatol , vol.7 , pp. 325-337
    • Van Bossuyt, H.1    De Zanger, R.B.2    Wisse, E.3
  • 63
    • 0024543089 scopus 로고
    • Clearance of gut-derived endotoxins by the liver. Release and modification of 3H, 14C-lipopolysaccharide by isolated rat Kupffer cells
    • Fox ES, Thomas P, Broitman SA. Clearance of gut-derived endotoxins by the liver. Release and modification of 3H, 14C-lipopolysaccharide by isolated rat Kupffer cells. Gastroenterology 1989:96:456-61.
    • (1989) Gastroenterology , vol.96 , pp. 456-461
    • Fox, E.S.1    Thomas, P.2    Broitman, S.A.3
  • 64
    • 0028804229 scopus 로고
    • Role of hepatocytes in direct clearance of lipopolysaccharide in rats
    • Mimura Y, Sakisaka S, Harada M, et al. Role of hepatocytes in direct clearance of lipopolysaccharide in rats. Gastroenterology 1995:109:1969-76.
    • (1995) Gastroenterology , vol.109 , pp. 1969-1976
    • Mimura, Y.1    Sakisaka, S.2    Harada, M.3
  • 65
    • 34250315765 scopus 로고    scopus 로고
    • A host lipase detoxifies bacterial lipopolysaccharides in the liver and spleen
    • Shao B, Lu M, Katz SC, et al. A host lipase detoxifies bacterial lipopolysaccharides in the liver and spleen. J Biol Chem 2007:282:13726-35.
    • (2007) J Biol Chem , vol.282 , pp. 13726-13735
    • Shao, B.1    Lu, M.2    Katz, S.C.3
  • 66
    • 0035865249 scopus 로고    scopus 로고
    • Lipopolysaccharide- induced IL-18 secretion from murine Kupffer cells independently of myeloid differentiation factor 88 that is critically involved in induction of production of IL-12 and IL-1 beta
    • Seki E, Tsutsui H, Nakano H, et al. Lipopolysaccharide- induced IL-18 secretion from murine Kupffer cells independently of myeloid differentiation factor 88 that is critically involved in induction of production of IL-12 and IL-1 beta. J Immunol 2001:166:2651-7.
    • (2001) J Immunol , vol.166 , pp. 2651-2657
    • Seki, E.1    Tsutsui, H.2    Nakano, H.3
  • 67
    • 0033179531 scopus 로고    scopus 로고
    • Regulation of macrophage chemokine expression by lipopolysaccharide in vitro and in vivo
    • Kopydlowski KM, Salkowski CA, Cody MJ, et al. Regulation of macrophage chemokine expression by lipopolysaccharide in vitro and in vivo. J Immunol 1999:163:1537-44.
    • (1999) J Immunol , vol.163 , pp. 1537-1544
    • Kopydlowski, K.M.1    Salkowski, C.A.2    Cody, M.J.3
  • 68
    • 0036785630 scopus 로고    scopus 로고
    • Critical roles of myeloid differentiation factor 88-dependent proinflammatory cytokine release in early phase clearance of Listens monocytogenes in mice
    • Seki E, Tsutsui H, Tsuji NM, et al. Critical roles of myeloid differentiation factor 88-dependent proinflammatory cytokine release in early phase clearance of Listens monocytogenes in mice. J Immunol 2002:169:3863-8.
    • (2002) J Immunol , vol.169 , pp. 3863-3868
    • Seki, E.1    Tsutsui, H.2    Tsuji, N.M.3
  • 69
    • 2442652487 scopus 로고    scopus 로고
    • HSP60 and CpG-DNA-oligonucleotides differentially regulate LPS-tolerance of hepatic Kupffer cells
    • Schuchmann M, Hermann F, Herkel J, et al. HSP60 and CpG-DNA-oligonucleotides differentially regulate LPS-tolerance of hepatic Kupffer cells. Immunol Lett 2004:93:199-204.
    • (2004) Immunol Lett , vol.93 , pp. 199-204
    • Schuchmann, M.1    Hermann, F.2    Herkel, J.3
  • 70
    • 28044463780 scopus 로고    scopus 로고
    • Toll-like receptor 3 ligand attenuates LPS-induced liver injury by down-regulation of toll-like receptor 4 expression on macrophages
    • Jiang W, Sun R, Wei H, et al. Toll-like receptor 3 ligand attenuates LPS-induced liver injury by down-regulation of toll-like receptor 4 expression on macrophages. Proc Natl Acad Sci U S A 2005:102: 17077-82.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 17077-17082
    • Jiang, W.1    Sun, R.2    Wei, H.3
  • 71
    • 33748431378 scopus 로고    scopus 로고
    • Src family kinases regulate p38 MAPK-mediated IL-6 production in Kupffer cells following hypoxia
    • Thobe BM, Frink M, Choudhry MA, et al. Src family kinases regulate p38 MAPK-mediated IL-6 production in Kupffer cells following hypoxia. Am J Physiol Cell Physiol 2006:291:C476-82.
    • (2006) Am J Physiol Cell Physiol , vol.291
    • Thobe, B.M.1    Frink, M.2    Choudhry, M.A.3
  • 72
    • 0028917669 scopus 로고
    • Human Kupffer cells secrete IL-10 in response to lipopolysaccharide (LPS) challenge
    • Knolle P, Schlaak J, Uhrig A, et al. Human Kupffer cells secrete IL-10 in response to lipopolysaccharide (LPS) challenge. J Hepatol 1995:22:226-9.
    • (1995) J Hepatol , vol.22 , pp. 226-229
    • Knolle, P.1    Schlaak, J.2    Uhrig, A.3
  • 73
    • 0036084728 scopus 로고    scopus 로고
    • Role of toll-like receptors in changes in gene expression and NF-kappa B activation in mouse hepatocytes stimulated with lipopolysaccharide
    • Liu S, Gallo DJ, Green AM, et al. Role of toll-like receptors in changes in gene expression and NF-kappa B activation in mouse hepatocytes stimulated with lipopolysaccharide. Infect Immun 2002:70:3433-42.
    • (2002) Infect Immun , vol.70 , pp. 3433-3442
    • Liu, S.1    Gallo, D.J.2    Green, A.M.3
  • 74
    • 0037954044 scopus 로고    scopus 로고
    • TRAF6-NF-kappaB pathway is essential for interleukin-1-induced TLR2 expression and its functional response to TLR2 ligand in murine hepatocytes
    • Matsumura T, Degawa T, Takii T, et al. TRAF6-NF-kappaB pathway is essential for interleukin-1-induced TLR2 expression and its functional response to TLR2 ligand in murine hepatocytes. Immunology 2003:109:127-36.
    • (2003) Immunology , vol.109 , pp. 127-136
    • Matsumura, T.1    Degawa, T.2    Takii, T.3
  • 75
    • 0033779915 scopus 로고    scopus 로고
    • Endotoxin and cytokine regulation of toll-like receptor (TLR) 2 and TLR4 gene expression in murine liver and hepatocytes
    • Matsumura T, Ito A, Takii T, et al. Endotoxin and cytokine regulation of toll-like receptor (TLR) 2 and TLR4 gene expression in murine liver and hepatocytes. J Interferon Cytokine Res 2000:20:915-21.
    • (2000) J Interferon Cytokine Res , vol.20 , pp. 915-921
    • Matsumura, T.1    Ito, A.2    Takii, T.3
  • 76
    • 57649142987 scopus 로고    scopus 로고
    • Beta 2-integrin induced p38MAPK activation is a key mediator in the CD14/TLR4/MD2-dependent uptake of LPS by hepatocytes
    • Scott MJ, Billiar TR. Beta 2-integrin induced p38MAPK activation is a key mediator in the CD14/TLR4/MD2-dependent uptake of LPS by hepatocytes. J Biol Chem 2008:283:29433-46.
    • (2008) J Biol Chem , vol.283 , pp. 29433-29446
    • Scott, M.J.1    Billiar, T.R.2
  • 78
    • 0038185316 scopus 로고    scopus 로고
    • Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells
    • Paik YH, Schwabe RF, Bataller R, et al. Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells. Hepatology 2003:37:1043-55.
    • (2003) Hepatology , vol.37 , pp. 1043-1055
    • Paik, Y.H.1    Schwabe, R.F.2    Bataller, R.3
  • 79
    • 24044432235 scopus 로고    scopus 로고
    • Exposure to bacterial cell wall products triggers an inflammatory phenotype in hepatic stellate cells
    • Brun P, Castagliuolo I, Pinzani M, et al. Exposure to bacterial cell wall products triggers an inflammatory phenotype in hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol 2005:289:G571-8.
    • (2005) Am J Physiol Gastrointest Liver Physiol , vol.289
    • Brun, P.1    Castagliuolo, I.2    Pinzani, M.3
  • 80
    • 52949125148 scopus 로고    scopus 로고
    • Role of TLR9 in hepatic stellate cells and experimental liver fibrosis
    • Gabele E, Muhlbauer M, Dorn C, et al. Role of TLR9 in hepatic stellate cells and experimental liver fibrosis. Biochem Biophys Res Commun 2008:376:271-6.
    • (2008) Biochem Biophys Res Commun , vol.376 , pp. 271-276
    • Gabele, E.1    Muhlbauer, M.2    Dorn, C.3
  • 81
    • 21644434942 scopus 로고    scopus 로고
    • Normal rat hepatic stellate cells respond to endotoxin in LBP-independent manner to produce inhibitor(s) of DNA synthesis in hepatocytes
    • Thirunavukkarasu C, Uemura T, Wang LF, et al. Normal rat hepatic stellate cells respond to endotoxin in LBP-independent manner to produce inhibitor(s) of DNA synthesis in hepatocytes. J Cell Physiol 2005:204:654-65.
    • (2005) J Cell Physiol , vol.204 , pp. 654-665
    • Thirunavukkarasu, C.1    Uemura, T.2    Wang, L.F.3
  • 82
    • 0242413703 scopus 로고    scopus 로고
    • Lipopolysaccharide activates nuclear factor-kappaB through toll-like receptors and related molecules in cultured biliary epithelial cells
    • Harada K, Ohira S, Isse K, et al. Lipopolysaccharide activates nuclear factor-kappaB through toll-like receptors and related molecules in cultured biliary epithelial cells. Lab Invest 2003:83:1657-67.
    • (2003) Lab Invest , vol.83 , pp. 1657-1667
    • Harada, K.1    Ohira, S.2    Isse, K.3
  • 83
    • 34249045984 scopus 로고    scopus 로고
    • Interaction of Toll-like receptors with bacterial components induces expression of CDX2 and MUC2 in rat biliary epithelium in vivo and in culture
    • Ikeda H, Sasaki M, Ishikawa A, et al. Interaction of Toll-like receptors with bacterial components induces expression of CDX2 and MUC2 in rat biliary epithelium in vivo and in culture. Lab Invest 2007:87:559-71.
    • (2007) Lab Invest , vol.87 , pp. 559-571
    • Ikeda, H.1    Sasaki, M.2    Ishikawa, A.3
  • 84
    • 28244478101 scopus 로고    scopus 로고
    • Multiple TLRs are expressed in human cholangiocytes and mediate host epithelial defense responses to Cryptosporidium parvum via activation of NF-kappaB
    • Chen XM, O'Hara SP, Nelson JB, et al. Multiple TLRs are expressed in human cholangiocytes and mediate host epithelial defense responses to Cryptosporidium parvum via activation of NF-kappaB. J Immunol 2005:175:7447-56.
    • (2005) J Immunol , vol.175 , pp. 7447-7456
    • Chen, X.M.1    O'Hara, S.P.2    Nelson, J.B.3
  • 85
    • 32544446183 scopus 로고    scopus 로고
    • Interferon gamma accelerates NF-kappaB activation of biliary epithelial cells induced by Toll-like receptor and ligand interaction
    • Harada K, Isse K, Nakanuma Y. Interferon gamma accelerates NF-kappaB activation of biliary epithelial cells induced by Toll-like receptor and ligand interaction. J Clin Pathol 2006:59:184-90.
    • (2006) J Clin Pathol , vol.59 , pp. 184-190
    • Harada, K.1    Isse, K.2    Nakanuma, Y.3
  • 86
    • 18244364834 scopus 로고    scopus 로고
    • Development and functional consequences of LPS tolerance in sinusoidal endothelial cells of the liver
    • Uhrig A, Banafsche R, Kremer M, et al. Development and functional consequences of LPS tolerance in sinusoidal endothelial cells of the liver. J Leukoc Biol 2005:77:626-33.
    • (2005) J Leukoc Biol , vol.77 , pp. 626-633
    • Uhrig, A.1    Banafsche, R.2    Kremer, M.3
  • 87
    • 33645757327 scopus 로고    scopus 로고
    • Toll-like receptor 9 (TLR9) is present in murine liver sinusoidal endothelial cells (LSECs) and mediates the effect of CpG-oligonucleotides
    • Martin-Armas M, Simon-Santamaria J, Pettersen I, et al. Toll-like receptor 9 (TLR9) is present in murine liver sinusoidal endothelial cells (LSECs) and mediates the effect of CpG-oligonucleotides. J Hepatol 2006:44:939-46.
    • (2006) J Hepatol , vol.44 , pp. 939-946
    • Martin-Armas, M.1    Simon-Santamaria, J.2    Pettersen, I.3
  • 88
    • 37749050365 scopus 로고    scopus 로고
    • Toll-like receptor-mediated control of HBV replication by nonparenchymal liver cells in mice
    • Wu J, Lu M, Meng Z, et al. Toll-like receptor-mediated control of HBV replication by nonparenchymal liver cells in mice. Hepatology 2007:46:1769-78.
    • (2007) Hepatology , vol.46 , pp. 1769-1778
    • Wu, J.1    Lu, M.2    Meng, Z.3
  • 89
    • 34447338577 scopus 로고    scopus 로고
    • The role of CD11c(+) hepatic dendritic cells in the induction of innate immune responses
    • Shu SA, Lian ZX, Chuang YH, et al. The role of CD11c(+) hepatic dendritic cells in the induction of innate immune responses. Clin Exp Immunol 2007:149:335-43.
    • (2007) Clin Exp Immunol , vol.149 , pp. 335-343
    • Shu, S.A.1    Lian, Z.X.2    Chuang, Y.H.3
  • 90
    • 0032446710 scopus 로고    scopus 로고
    • Role of endotoxin in the hypermetabolic state after acute ethanol exposure
    • Rivera CA, Bradford BU, Seabra V, et al. Role of endotoxin in the hypermetabolic state after acute ethanol exposure. Am J Physiol 1998:275:G1252-8.
    • (1998) Am J Physiol , vol.275
    • Rivera, C.A.1    Bradford, B.U.2    Seabra, V.3
  • 91
    • 0028796860 scopus 로고
    • Antibiotics prevent liver injury in rats following long-term exposure to ethanol
    • Adachi Y, Moore LE, Bradford BU, etal. Antibiotics prevent liver injury in rats following long-term exposure to ethanol. Gastroenterology 1995:108:218-24.
    • (1995) Gastroenterology , vol.108 , pp. 218-224
    • Adachi, Y.1    Moore, L.E.2    Bradford, B.U.3
  • 92
    • 0027992143 scopus 로고
    • The role of tumor necrosis factor-alpha in acute endotoxin-induced hepatotoxicity in ethanol-fed rats
    • Hansen J, Cherwitz DL, Allen Jl. The role of tumor necrosis factor-alpha in acute endotoxin-induced hepatotoxicity in ethanol-fed rats. Hepatology 1994:20:461-74.
    • (1994) Hepatology , vol.20 , pp. 461-474
    • Hansen, J.1    Cherwitz, D.L.2    Allen, J.3
  • 93
    • 0021235523 scopus 로고
    • Jejunal microflora in patients with chronic alcohol abuse
    • Bode JC, Bode C, Heidelbach R, et al. Jejunal microflora in patients with chronic alcohol abuse. Hepatogastroenterology 1984:31:30-4.
    • (1984) Hepatogastroenterology , vol.31 , pp. 30-34
    • Bode, J.C.1    Bode, C.2    Heidelbach, R.3
  • 94
    • 0030665863 scopus 로고    scopus 로고
    • Mucosal bacterial growth in the upper gastrointestinal tract in alcoholics (heavy drinkers)
    • Hauge T, Persson J, Danielsson D. Mucosal bacterial growth in the upper gastrointestinal tract in alcoholics (heavy drinkers). Digestion 1997:58:591-5.
    • (1997) Digestion , vol.58 , pp. 591-595
    • Hauge, T.1    Persson, J.2    Danielsson, D.3
  • 95
    • 0017887673 scopus 로고
    • Effect of daily ethanol ingestion on intestinal permeability to macromolecules
    • Worthington BS, Meserole L, Syrotuck JA. Effect of daily ethanol ingestion on intestinal permeability to macromolecules. AmJDigDis 1978:23:23-32.
    • (1978) AmJDigDis , vol.23 , pp. 23-32
    • Worthington, B.S.1    Meserole, L.2    Syrotuck, J.A.3
  • 96
    • 0020631480 scopus 로고
    • Effect of alcohol on the integrity of the intestinal epithelium
    • Draper LR, Gyure LA, Hall JG, et al. Effect of alcohol on the integrity of the intestinal epithelium. Gut 1983:24:399-404.
    • (1983) Gut , vol.24 , pp. 399-404
    • Draper, L.R.1    Gyure, L.A.2    Hall, J.G.3
  • 97
    • 0021352090 scopus 로고
    • The leaky gut of alcoholism: Possible route of entry for toxic compounds
    • Bjarnason I, Peters TJ, Wise RJ. The leaky gut of alcoholism: possible route of entry for toxic compounds. Lancet 1984:1:179-82.
    • (1984) Lancet , vol.1 , pp. 179-182
    • Bjarnason, I.1    Peters, T.J.2    Wise, R.J.3
  • 98
    • 33645449666 scopus 로고    scopus 로고
    • Impairment of the intestinal barrier by ethanol involves enteric microflora and mast cell activation in rodents
    • Ferrier L, Berard F, Debrauwer L, et al. Impairment of the intestinal barrier by ethanol involves enteric microflora and mast cell activation in rodents. Am J Pathol 2006:168:1148-54.
    • (2006) Am J Pathol , vol.168 , pp. 1148-1154
    • Ferrier, L.1    Berard, F.2    Debrauwer, L.3
  • 99
    • 46449126460 scopus 로고    scopus 로고
    • Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: Summary of a symposium
    • Purohit V, Bode JC, Bode C, et al. Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: summary of a symposium. Alcohol 2008:42:349-61.
    • (2008) Alcohol , vol.42 , pp. 349-361
    • Purohit, V.1    Bode, J.C.2    Bode, C.3
  • 100
    • 0028108372 scopus 로고
    • Inactivation of Kupffer cells prevents early alcohol-induced liver injury
    • Adachi Y, Bradford BU, Gao W, etal. Inactivation of Kupffer cells prevents early alcohol-induced liver injury. Hepatology 1994:20:453-60.
    • (1994) Hepatology , vol.20 , pp. 453-460
    • Adachi, Y.1    Bradford, B.U.2    Gao, W.3
  • 101
    • 0034950477 scopus 로고    scopus 로고
    • Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice
    • Uesugi T, Froh M, Arteel GE, et al. Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice. Hepatology 2001:34:101-8.
    • (2001) Hepatology , vol.34 , pp. 101-108
    • Uesugi, T.1    Froh, M.2    Arteel, G.E.3
  • 102
    • 54449092214 scopus 로고    scopus 로고
    • The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88
    • Hritz I, Mandrekar P, Velayudham A, et al. The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88. Hepatology 2008:48:1244-31.
    • (2008) Hepatology , vol.48 , pp. 1244-1331
    • Hritz, I.1    Mandrekar, P.2    Velayudham, A.3
  • 103
    • 0033802236 scopus 로고    scopus 로고
    • NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease
    • Kono H, Rusyn I, Yin M, et al. NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease. J Clin Invest 2000:106:867-72.
    • (2000) J Clin Invest , vol.106 , pp. 867-872
    • Kono, H.1    Rusyn, I.2    Yin, M.3
  • 105
    • 33845901507 scopus 로고    scopus 로고
    • Microbial ecology: Human gut microbes associated with obesity
    • Ley RE, Turnbaugh PJ, Klein S, et al. Microbial ecology: human gut microbes associated with obesity. Nature 2006:444:1022- 3.
    • (2006) Nature , vol.444 , pp. 1022-1023
    • Ley, R.E.1    Turnbaugh, P.J.2    Klein, S.3
  • 106
    • 33845874101 scopus 로고    scopus 로고
    • An obesity-associated gut microbiome with increased capacity for energy harvest
    • Turnbaugh PJ, Ley RE, Mahowald MA, etal. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 2006:444:1027-31.
    • (2006) Nature , vol.444 , pp. 1027-1031
    • Turnbaugh, P.J.1    Ley, R.E.2    Mahowald, M.A.3
  • 107
    • 34347399563 scopus 로고    scopus 로고
    • Metabolic endotoxemia initiates obesity and insulin resistance
    • Cani PD, Amar J, Iglesias MA, et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 2007:56:1761- 72.
    • (2007) Diabetes , vol.56 , pp. 1761-1772
    • Cani, P.D.1    Amar, J.2    Iglesias, M.A.3
  • 108
    • 33847040759 scopus 로고    scopus 로고
    • Increased intestinal permeability in obese mice: New evidence in the pathogenesis of nonalcoholic steatohepatitis
    • Brun P, Castagliuolo I, Di Leo V, et al. Increased intestinal permeability in obese mice: new evidence in the pathogenesis of nonalcoholic steatohepatitis. Am J Physiol Gastrointest Liver Physiol 2007;292:G518-25.
    • (2007) Am J Physiol Gastrointest Liver Physiol , vol.292
    • Brun, P.1    Castagliuolo, I.2    Di Leo, V.3
  • 109
    • 48249125862 scopus 로고    scopus 로고
    • Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice
    • Cani PD, Bibiloni R, Knauf C, et al. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes 2008:57:1470- 81.
    • (2008) Diabetes , vol.57 , pp. 1470-1481
    • Cani, P.D.1    Bibiloni, R.2    Knauf, C.3
  • 110
    • 46749098265 scopus 로고    scopus 로고
    • Gut microbiota modulation with norfloxacin and ampicillin enhances glucose tolerance in mice
    • Membrez M, Blancher F, Jaquet M, et al. Gut microbiota modulation with norfloxacin and ampicillin enhances glucose tolerance in mice. FASEB J 2008:22:2416-26.
    • (2008) FASEB J , vol.22 , pp. 2416-2426
    • Membrez, M.1    Blancher, F.2    Jaquet, M.3
  • 111
    • 0001513966 scopus 로고    scopus 로고
    • Obesity increases sensitivity to endotoxin liver injury: Implications for the pathogenesis of steatohepatitis
    • Yang SQ, Lin HZ, Lane MD, et al. Obesity increases sensitivity to endotoxin liver injury: implications for the pathogenesis of steatohepatitis. Proc Natl Acad Sci USA 1997:94:2557-62.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 2557-2562
    • Yang, S.Q.1    Lin, H.Z.2    Lane, M.D.3
  • 112
    • 34548272744 scopus 로고    scopus 로고
    • Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis
    • Rivera CA, Adegboyega P, van Rooijen N, et al. Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis. J Hepatol 2007:47:571-9.
    • (2007) J Hepatol , vol.47 , pp. 571-579
    • Rivera, C.A.1    Adegboyega, P.2    van Rooijen, N.3
  • 113
    • 32044438279 scopus 로고    scopus 로고
    • Modulation of nonalcoholic steatohepatitis by pattern recognition receptors in mice: The role of toll-like receptors 2 and 4
    • Szabo G, Velayudham A, Romics L Jr, et al. Modulation of nonalcoholic steatohepatitis by pattern recognition receptors in mice: the role of toll-like receptors 2 and 4. Alcohol Clin Exp Res 2005:29:140S- 5S.
    • (2005) Alcohol Clin Exp Res , vol.29
    • Szabo, G.1    Velayudham, A.2    Romics Jr, L.3
  • 114
    • 0037309589 scopus 로고    scopus 로고
    • Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease
    • li Z, Yang S, Lin H, et al. Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease. Hepatology 2003:37:343-50.
    • (2003) Hepatology , vol.37 , pp. 343-350
    • li, Z.1    Yang, S.2    Lin, H.3
  • 115
    • 0017864453 scopus 로고
    • Endotoxin and the liver. III. Modification of acute carbon tetrachloride injury by polymyxin b - an antiendotoxin
    • Nolan JP, Leibowitz Al. Endotoxin and the liver. III. Modification of acute carbon tetrachloride injury by polymyxin b - an antiendotoxin. Gastroenterology 1978:75:445-9.
    • (1978) Gastroenterology , vol.75 , pp. 445-449
    • Nolan, J.P.1    Leibowitz, A.2
  • 116
    • 0029057032 scopus 로고
    • Experimental biliary fibrosis correlates with increased numbers of fat-storing and Kupffer cells, and portal endotoxemia
    • Grinko I, Geerts A, Wisse E. Experimental biliary fibrosis correlates with increased numbers of fat-storing and Kupffer cells, and portal endotoxemia. J Hepatol 1995:23:449-58.
    • (1995) J Hepatol , vol.23 , pp. 449-458
    • Grinko, I.1    Geerts, A.2    Wisse, E.3
  • 117
    • 0030808419 scopus 로고    scopus 로고
    • Prognostic value of plasma endotoxin levels in patients with cirrhosis
    • Chan CC, Hwang SJ, Lee FY, et al. Prognostic value of plasma endotoxin levels in patients with cirrhosis. Scand J Gastroenterol 1997:32:942-6.
    • (1997) Scand J Gastroenterol , vol.32 , pp. 942-946
    • Chan, C.C.1    Hwang, S.J.2    Lee, F.Y.3
  • 118
    • 0028934072 scopus 로고
    • Endotoxemia in patients with chronic liver diseases: Relationship to severity of liver diseases, presence of esophageal varices, and hyperdynamic circulation
    • Lin RS, Lee FY, Lee SD, et al. Endotoxemia in patients with chronic liver diseases: relationship to severity of liver diseases, presence of esophageal varices, and hyperdynamic circulation. J Hepatol 1995:22:165-72.
    • (1995) J Hepatol , vol.22 , pp. 165-172
    • Lin, R.S.1    Lee, F.Y.2    Lee, S.D.3
  • 119
    • 0027232738 scopus 로고
    • Abnormalities in proximal small bowel motility in patients with cirrhosis
    • Chesta J, Defilippi C. Abnormalities in proximal small bowel motility in patients with cirrhosis. Hepatology 1993:17:828-32.
    • (1993) Hepatology , vol.17 , pp. 828-832
    • Chesta, J.1    Defilippi, C.2
  • 120
    • 0030874289 scopus 로고    scopus 로고
    • Intestinal bacterial overgrowth and bacterial translocation in cirrhotic rats with ascites
    • Guarner C, Runyon BA, Young S, et al. Intestinal bacterial overgrowth and bacterial translocation in cirrhotic rats with ascites. J Hepatol 1997:26:1372-8.
    • (1997) J Hepatol , vol.26 , pp. 1372-1378
    • Guarner, C.1    Runyon, B.A.2    Young, S.3
  • 121
    • 0036186390 scopus 로고    scopus 로고
    • Intestinal mucosal alterations in experimental cirrhosis in the rat: Role of oxygen free radicals
    • Ramachandran A, Prabhu R, Thomas S, et al. Intestinal mucosal alterations in experimental cirrhosis in the rat: role of oxygen free radicals. Hepatology 2002:35:622-9.
    • (2002) Hepatology , vol.35 , pp. 622-629
    • Ramachandran, A.1    Prabhu, R.2    Thomas, S.3
  • 122
    • 0022641263 scopus 로고
    • Abnormalities of neutrophil phagocytosis, intracellular killing and metabolic activity in alcoholic cirrhosis and hepatitis
    • Rajkovic IA, Williams R. Abnormalities of neutrophil phagocytosis, intracellular killing and metabolic activity in alcoholic cirrhosis and hepatitis. Hepatology 1986:6:252-62.
    • (1986) Hepatology , vol.6 , pp. 252-262
    • Rajkovic, I.A.1    Williams, R.2
  • 123
    • 0029064469 scopus 로고
    • Bacterial translocation to mesenteric lymph nodes is increased in cirrhotic rats with ascites
    • Garcia-Tsao G, Lee FY, Barden GE, et al. Bacterial translocation to mesenteric lymph nodes is increased in cirrhotic rats with ascites. Gastroenterology 1995:108:1835-41.
    • (1995) Gastroenterology , vol.108 , pp. 1835-1841
    • Garcia-Tsao, G.1    Lee, F.Y.2    Barden, G.E.3
  • 125
    • 78651037890 scopus 로고
    • The role of intestinal bacteria in the development of dietary cirrhosis in rats
    • Rutenburg AM, Sonnenblick E, Koven I, et al. The role of intestinal bacteria in the development of dietary cirrhosis in rats. JExpMed 1957:106:1-14.
    • (1957) JExpMed , vol.106 , pp. 1-14
    • Rutenburg, A.M.1    Sonnenblick, E.2    Koven, I.3
  • 126
    • 33646862383 scopus 로고    scopus 로고
    • LPS signaling enhances hepatic fibrogenesis caused by experimental cholestasis in mice
    • Isayama F, Hines IN, Kremer M, et al. LPS signaling enhances hepatic fibrogenesis caused by experimental cholestasis in mice. Am J Physiol Gastrointest Liver Physiol 2006;290:G1318-28.
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.290
    • Isayama, F.1    Hines, I.N.2    Kremer, M.3
  • 127
    • 66449101770 scopus 로고    scopus 로고
    • A 7 gene signature identifies the risk of developing cirrhosis in patients with chronic hepatitis
    • Huang H, Shiftman ML, Friedman S, et al. A 7 gene signature identifies the risk of developing cirrhosis in patients with chronic hepatitis . Hepatology 2007;46:1509-18.
    • (2007) Hepatology , vol.46 , pp. 1509-1518
    • Huang, H.1    Shiftman, M.L.2    Friedman, S.3
  • 128
    • 36348997503 scopus 로고    scopus 로고
    • Apoptotic hepatocyte DNA inhibits hepatic stellate cell chemotaxis via toll-like receptor 9
    • Watanabe A, Hashmi A, Gomes DA, et al. Apoptotic hepatocyte DNA inhibits hepatic stellate cell chemotaxis via toll-like receptor 9. Hepatology 2007:46:1509-18.
    • (2007) Hepatology , vol.46 , pp. 1509-1518
    • Watanabe, A.1    Hashmi, A.2    Gomes, D.A.3
  • 129
    • 66449093327 scopus 로고    scopus 로고
    • Inhibitory control test for the treatment of minimal hepatic encephalopathy
    • Bajaj JS, Hafeezullah M, Franco J, et al. Inhibitory control test for the treatment of minimal hepatic encephalopathy. Gastroenterol 2008;103:1 707-15.
    • (2008) Gastroenterol , vol.103 , Issue.1 , pp. 707-715
    • Bajaj, J.S.1    Hafeezullah, M.2    Franco, J.3
  • 130
    • 50649088399 scopus 로고    scopus 로고
    • Probiotic yogurt for the treatment of minimal hepatic encephalopathy
    • Bajaj JS, Saeian K, Christensen KM, et al. Probiotic yogurt for the treatment of minimal hepatic encephalopathy. Am J Gastroenterol 2008:103:1707-15.
    • (2008) Am J Gastroenterol , vol.103 , pp. 1707-1715
    • Bajaj, J.S.1    Saeian, K.2    Christensen, K.M.3
  • 131
    • 0029066628 scopus 로고
    • Long-term effects of Enterococcus faecium SF68 versus lactulose in the treatment of patients with cirrhosis and grade 1-2 hepatic encephalopathy
    • Loguercio C, Abbiati R, Rinaldi M, et al. Long-term effects of Enterococcus faecium SF68 versus lactulose in the treatment of patients with cirrhosis and grade 1-2 hepatic encephalopathy. J Hepatol 1995:23:39-46.
    • (1995) J Hepatol , vol.23 , pp. 39-46
    • Loguercio, C.1    Abbiati, R.2    Rinaldi, M.3
  • 132
    • 2342580955 scopus 로고    scopus 로고
    • Synbiotic modulation of gut flora: Effect on minimal hepatic encephalopathy in patients with cirrhosis
    • Liu Q, Duan ZP, Ha DK, et al. Synbiotic modulation of gut flora: effect on minimal hepatic encephalopathy in patients with cirrhosis. Hepatology 2004:39:1441-9.
    • (2004) Hepatology , vol.39 , pp. 1441-1449
    • Liu, Q.1    Duan, Z.P.2    Ha, D.K.3
  • 133
    • 0037219393 scopus 로고    scopus 로고
    • Increased lipopolysaccharide binding protein in cirrhotic patients with marked immune and hemodynamic derangement
    • Albillos A, de la Hera A, Gonzalez M, et al. Increased lipopolysaccharide binding protein in cirrhotic patients with marked immune and hemodynamic derangement. Hepatology 2003:37:208-17.
    • (2003) Hepatology , vol.37 , pp. 208-217
    • Albillos, A.1    de la Hera, A.2    Gonzalez, M.3
  • 134
    • 1642535481 scopus 로고    scopus 로고
    • The effect of selective intestinal decontamination on the hyperdynamic circulatory state in cirrhosis. A randomized trial
    • Rasaratnam B, Kaye D, Jennings G, et al. The effect of selective intestinal decontamination on the hyperdynamic circulatory state in cirrhosis. A randomized trial. Ann Intern Med 2003:139:186-93.
    • (2003) Ann Intern Med , vol.139 , pp. 186-193
    • Rasaratnam, B.1    Kaye, D.2    Jennings, G.3
  • 135
    • 59849111712 scopus 로고    scopus 로고
    • Norfloxacin treatment for clinically significant portal hypertension: Results of a randomised double-blind placebo-controlled crossover trial
    • Kemp W, Colman J, Thompson K, et al. Norfloxacin treatment for clinically significant portal hypertension: results of a randomised double-blind placebo-controlled crossover trial. Liver Int 2008:29:427-33.
    • (2008) Liver Int , vol.29 , pp. 427-433
    • Kemp, W.1    Colman, J.2    Thompson, K.3
  • 136
    • 5444250952 scopus 로고
    • Aetiologie der neoplastischen Geschwulste/ Pathogenie der neoplastischen Geschwulste
    • Virchow R, ed, Berlin: Verlag von August von Hirschwald
    • Virchow R. Aetiologie der neoplastischen Geschwulste/ Pathogenie der neoplastischen Geschwulste. In: Virchow R, ed. Die krankhaften Geschwulste. Berlin: Verlag von August von Hirschwald, 1863:57-101.
    • (1863) Die krankhaften Geschwulste , pp. 57-101
    • Virchow, R.1
  • 137
    • 7044229778 scopus 로고    scopus 로고
    • Primary liver cancer: Worldwide incidence and trends
    • Bosch FX, Ribes J, Diaz M, et al. Primary liver cancer: worldwide incidence and trends. Gastroenterology 2004:127:S5-S16.
    • (2004) Gastroenterology , vol.127
    • Bosch, F.X.1    Ribes, J.2    Diaz, M.3
  • 138
    • 34447327216 scopus 로고    scopus 로고
    • Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production
    • Naugler WE, Sakurai T, Kim S, et al. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science 2007:317:121-4.
    • (2007) Science , vol.317 , pp. 121-124
    • Naugler, W.E.1    Sakurai, T.2    Kim, S.3
  • 139
    • 48649109203 scopus 로고    scopus 로고
    • Hepatocyte necrosis induced by oxidative stress and IL-1 alpha release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis
    • Sakurai T, He G, Matsuzawa A, et al. Hepatocyte necrosis induced by oxidative stress and IL-1 alpha release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis. Cancer Cell 2008:14:156-65.
    • (2008) Cancer Cell , vol.14 , pp. 156-165
    • Sakurai, T.1    He, G.2    Matsuzawa, A.3
  • 140
    • 33646852746 scopus 로고    scopus 로고
    • The prevalence of hepatitis C virus infection in the United States, 1999 through 2002
    • Armstrong GL, Wasley A, Simard EP, et al. The prevalence of hepatitis C virus infection in the United States, 1999 through 2002. Ann Intern Med 2006:144:705-14.
    • (2006) Ann Intern Med , vol.144 , pp. 705-714
    • Armstrong, G.L.1    Wasley, A.2    Simard, E.P.3
  • 141
    • 42949133318 scopus 로고    scopus 로고
    • Controversies in liver transplantation for hepatitis C
    • Mukherjee S, Sorrell MF. Controversies in liver transplantation for hepatitis C. Gastroenterology 2008:134:1777-88.
    • (2008) Gastroenterology , vol.134 , pp. 1777-1788
    • Mukherjee, S.1    Sorrell, M.F.2
  • 142
    • 35649007401 scopus 로고    scopus 로고
    • Viral and host factors induce macrophage activation and loss of toll-like receptor tolerance in chronic HCV infection
    • Dolganiuc A, Norkina 0, Kodys K, et al. Viral and host factors induce macrophage activation and loss of toll-like receptor tolerance in chronic HCV infection. Gastroenterology 2007:133:1627-36.
    • (2007) Gastroenterology , vol.133 , pp. 1627-1636
    • Dolganiuc, A.1    Norkina 02    Kodys, K.3
  • 143
    • 7644226241 scopus 로고    scopus 로고
    • Hepatitis C core and nonstructural 3 proteins trigger toll-like receptor 2-mediated pathways and inflammatory activation
    • Dolganiuc A, Oak S, Kodys K, et al. Hepatitis C core and nonstructural 3 proteins trigger toll-like receptor 2-mediated pathways and inflammatory activation. Gastroenterology 2004:127:1513-24.
    • (2004) Gastroenterology , vol.127 , pp. 1513-1524
    • Dolganiuc, A.1    Oak, S.2    Kodys, K.3
  • 144
    • 34548418137 scopus 로고    scopus 로고
    • Toll-like receptors 1 and 6 are involved in TLR2-mediated macrophage activation by hepatitis C virus core and NS3 proteins
    • Chang S, Dolganiuc A, Szabo G. Toll-like receptors 1 and 6 are involved in TLR2-mediated macrophage activation by hepatitis C virus core and NS3 proteins. J Leukoc Biol 2007:82:479-87.
    • (2007) J Leukoc Biol , vol.82 , pp. 479-487
    • Chang, S.1    Dolganiuc, A.2    Szabo, G.3
  • 145
    • 14944375587 scopus 로고    scopus 로고
    • Immunology of hepatitis B virus and hepatitis C virus infection
    • Rehermann B, Nascimbeni M. Immunology of hepatitis B virus and hepatitis C virus infection. Nat Rev Immunol 2005:5:215-29.
    • (2005) Nat Rev Immunol , vol.5 , pp. 215-229
    • Rehermann, B.1    Nascimbeni, M.2
  • 146
    • 46749154594 scopus 로고    scopus 로고
    • Immune responses during acute and chronic infection with hepatitis C virus
    • Ishii S, Koziel MJ. Immune responses during acute and chronic infection with hepatitis C virus. Clin Immunol 2008:128:133-47.
    • (2008) Clin Immunol , vol.128 , pp. 133-147
    • Ishii, S.1    Koziel, M.J.2
  • 147
    • 14544280209 scopus 로고    scopus 로고
    • Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF
    • Li K, Foy E, Ferreon JC, et al. Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF. Proc Natl Acad Sci USA 2005:102:2992-7.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 2992-2997
    • Li, K.1    Foy, E.2    Ferreon, J.C.3
  • 148
    • 17844395681 scopus 로고    scopus 로고
    • Interaction between the HCV NS3 protein and the host TBK1 protein leads to inhibition of cellular antiviral responses
    • Otsuka M, Kato N, Moriyama M, et al. Interaction between the HCV NS3 protein and the host TBK1 protein leads to inhibition of cellular antiviral responses. Hepatology 2005:41:1004-12.
    • (2005) Hepatology , vol.41 , pp. 1004-1012
    • Otsuka, M.1    Kato, N.2    Moriyama, M.3
  • 149
    • 34548178194 scopus 로고    scopus 로고
    • Hepatitis C virus nonstructural protein 5A modulates the toll-like receptor-MyD88-dependent signaling pathway in macrophage cell lines
    • Abe T, Kaname Y, Hamamoto I, et al. Hepatitis C virus nonstructural protein 5A modulates the toll-like receptor-MyD88-dependent signaling pathway in macrophage cell lines. J Virol 2007:81:8953- 66.
    • (2007) J Virol , vol.81 , pp. 8953-8966
    • Abe, T.1    Kaname, Y.2    Hamamoto, I.3
  • 150
    • 43249118725 scopus 로고    scopus 로고
    • Impaired cytokine response in myeloid dendritic cells in chronic hepatitis C virus infection regardless of enhanced expression of Toll-like receptors and retinoic acid inducible gene-l
    • Miyazaki M, Kanto T, Inoue M, et al. Impaired cytokine response in myeloid dendritic cells in chronic hepatitis C virus infection regardless of enhanced expression of Toll-like receptors and retinoic acid inducible gene-l. J Med Virol 2008:80:980-8.
    • (2008) J Med Virol , vol.80 , pp. 980-988
    • Miyazaki, M.1    Kanto, T.2    Inoue, M.3
  • 151
    • 39549097752 scopus 로고    scopus 로고
    • Cell culture-produced hepatitis C virus impairs plasmacytoid dendritic cell function
    • Shiina M, Rehermann B. Cell culture-produced hepatitis C virus impairs plasmacytoid dendritic cell function. Hepatology 2008:47:385-95.
    • (2008) Hepatology , vol.47 , pp. 385-395
    • Shiina, M.1    Rehermann, B.2
  • 152
    • 33947661034 scopus 로고    scopus 로고
    • TLR ligand-dependent activation of naive CD4 T cells by plasmacytoid dendritic cells is impaired in hepatitis C virus infection
    • Yonkers NL, Rodriguez B, Milkovich KA, et al. TLR ligand-dependent activation of naive CD4 T cells by plasmacytoid dendritic cells is impaired in hepatitis C virus infection. J Immunol 2007:178:4436-44.
    • (2007) J Immunol , vol.178 , pp. 4436-4444
    • Yonkers, N.L.1    Rodriguez, B.2    Milkovich, K.A.3
  • 153
    • 24144448068 scopus 로고    scopus 로고
    • Isatoribine, an agonist of TLR7, reduces plasma virus concentration in chronic hepatitis C infection
    • Horsmans Y, Berg T, Desager JP, et al. Isatoribine, an agonist of TLR7, reduces plasma virus concentration in chronic hepatitis C infection. Hepatology 2005:42:724-31.
    • (2005) Hepatology , vol.42 , pp. 724-731
    • Horsmans, Y.1    Berg, T.2    Desager, J.P.3
  • 154
    • 30344444475 scopus 로고    scopus 로고
    • Hepatitis C virus induces toll-like receptor 4 expression, leading to enhanced production of beta interferon and interleukin-6
    • Machida K, Cheng KT, Sung VM, et al. Hepatitis C virus induces toll-like receptor 4 expression, leading to enhanced production of beta interferon and interleukin-6. J Virol 2006:80:866-74.
    • (2006) J Virol , vol.80 , pp. 866-874
    • Machida, K.1    Cheng, K.T.2    Sung, V.M.3
  • 155
    • 0030707941 scopus 로고    scopus 로고
    • Hepatitis B virus infection
    • Lee WM. Hepatitis B virus infection. N Engl J Med 1997:337:1733-45.
    • (1997) N Engl J Med , vol.337 , pp. 1733-1745
    • Lee, W.M.1
  • 156
    • 0036345231 scopus 로고    scopus 로고
    • Systemic endotoxemia during chronic viral hepatitis
    • Sozinov AS. Systemic endotoxemia during chronic viral hepatitis. Bull Exp Biol Med 2002:133:153-5.
    • (2002) Bull Exp Biol Med , vol.133 , pp. 153-155
    • Sozinov, A.S.1
  • 157
    • 23844455909 scopus 로고    scopus 로고
    • Cytokine induction by the hepatitis B virus capsid in macrophages is facilitated by membrane heparan sulfate and involves TLR2
    • Cooper A, Tal G, Lider 0, et al. Cytokine induction by the hepatitis B virus capsid in macrophages is facilitated by membrane heparan sulfate and involves TLR2. J Immunol 2005:175:3165-76.
    • (2005) J Immunol , vol.175 , pp. 3165-3176
    • Cooper, A.1    Tal, G.2    Lider 03
  • 158
    • 0033951066 scopus 로고    scopus 로고
    • Relative sensitivity of hepatitis B virus and other hepatotropic viruses to the antiviral effects of cytokines
    • McClary H, Koch R, Chisari FV, et al. Relative sensitivity of hepatitis B virus and other hepatotropic viruses to the antiviral effects of cytokines. J Virol 2000:74:2255-64.
    • (2000) J Virol , vol.74 , pp. 2255-2264
    • McClary, H.1    Koch, R.2    Chisari, F.V.3
  • 159
    • 18744399291 scopus 로고    scopus 로고
    • Toll-like receptor signaling inhibits hepatitis B virus replication in vivo
    • Isogawa M, Robek MD, Furuichi Y, et al. Toll-like receptor signaling inhibits hepatitis B virus replication in vivo. J Virol 2005:79:7269-72.
    • (2005) J Virol , vol.79 , pp. 7269-7272
    • Isogawa, M.1    Robek, M.D.2    Furuichi, Y.3
  • 160
    • 49149128080 scopus 로고    scopus 로고
    • Expression profiles and function of Toll-like receptors 2 and 4 in peripheral blood mononuclear cells of chronic hepatitis B patients
    • Chen Z, Cheng Y, Xu Y, et al. Expression profiles and function of Toll-like receptors 2 and 4 in peripheral blood mononuclear cells of chronic hepatitis B patients. Clin Immunol 2008:128:400-8.
    • (2008) Clin Immunol , vol.128 , pp. 400-408
    • Chen, Z.1    Cheng, Y.2    Xu, Y.3
  • 161
    • 33846492518 scopus 로고    scopus 로고
    • Regulation of Toll-like receptor-2 expression in chronic hepatitis B by the precore protein
    • Visvanathan K, Skinner NA, Thompson AJ, et al. Regulation of Toll-like receptor-2 expression in chronic hepatitis B by the precore protein. Hepatology 2007:45:102-10.
    • (2007) Hepatology , vol.45 , pp. 102-110
    • Visvanathan, K.1    Skinner, N.A.2    Thompson, A.J.3
  • 162
    • 11344257404 scopus 로고    scopus 로고
    • CPG 7909, an immunostimulatory TLR9 agonist oligodeoxynucleotide, as adjuvant to Engerix-B HBV vaccine in healthy adults: A double-blind phase I/I I study
    • Cooper CL, Davis HL, Morris ML, et al. CPG 7909, an immunostimulatory TLR9 agonist oligodeoxynucleotide, as adjuvant to Engerix-B HBV vaccine in healthy adults: a double-blind phase I/I I study. J Clin Immunol 2004:24:693-701.
    • (2004) J Clin Immunol , vol.24 , pp. 693-701
    • Cooper, C.L.1    Davis, H.L.2    Morris, M.L.3
  • 163
    • 26644447379 scopus 로고    scopus 로고
    • TLR agonists as vaccine adjuvants: Comparison of CpG ODN and Resiquimod (R-848)
    • Weeratna RD, Makinen SR, McCluskie MJ, et al. TLR agonists as vaccine adjuvants: comparison of CpG ODN and Resiquimod (R-848). Vaccine 2005:23:5263-70.
    • (2005) Vaccine , vol.23 , pp. 5263-5270
    • Weeratna, R.D.1    Makinen, S.R.2    McCluskie, M.J.3
  • 164
    • 34547533793 scopus 로고    scopus 로고
    • Additive effects of CpG ODN and R-848 as adjuvants on augmenting immune responses to HBsAg vaccination
    • Ma R, Du JL, Huang J, et al. Additive effects of CpG ODN and R-848 as adjuvants on augmenting immune responses to HBsAg vaccination. Biochem Biophys Res Commun 2007:361:537-42.
    • (2007) Biochem Biophys Res Commun , vol.361 , pp. 537-542
    • Ma, R.1    Du, J.L.2    Huang, J.3
  • 165
    • 20044385554 scopus 로고    scopus 로고
    • Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease
    • Lang KS, Recher M, Junt T, et al. Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease. Nat Med 2005:11:138-45.
    • (2005) Nat Med , vol.11 , pp. 138-145
    • Lang, K.S.1    Recher, M.2    Junt, T.3
  • 166
    • 0037487251 scopus 로고    scopus 로고
    • Primary biliary cirrhosis
    • Talwalkar JA, Lindor KD. Primary biliary cirrhosis. Lancet 2003:362:53-61.
    • (2003) Lancet , vol.362 , pp. 53-61
    • Talwalkar, J.A.1    Lindor, K.D.2
  • 167
    • 40949118946 scopus 로고    scopus 로고
    • Biliary epithelial cells and primary biliary cirrhosis: The role of liver-infiltrating mononuclear cells
    • Shimoda S, Harada K, Niiro H, et al. Biliary epithelial cells and primary biliary cirrhosis: the role of liver-infiltrating mononuclear cells. Hepatology 2008:47:958-65.
    • (2008) Hepatology , vol.47 , pp. 958-965
    • Shimoda, S.1    Harada, K.2    Niiro, H.3
  • 168
    • 22544446433 scopus 로고    scopus 로고
    • Enhanced expression of type I interferon and toll-like receptor-3 in primary biliary cirrhosis
    • Takii Y, Nakamura M, Ito M, et al. Enhanced expression of type I interferon and toll-like receptor-3 in primary biliary cirrhosis. Lab Invest 2005:85:908-20.
    • (2005) Lab Invest , vol.85 , pp. 908-920
    • Takii, Y.1    Nakamura, M.2    Ito, M.3
  • 169
    • 25844471675 scopus 로고    scopus 로고
    • Altered monocyte responses to defined TLR ligands in patients with primary biliary cirrhosis
    • Mao TK, Lian ZX, Selmi C, et al. Altered monocyte responses to defined TLR ligands in patients with primary biliary cirrhosis. Hepatology 2005:42:802-8.
    • (2005) Hepatology , vol.42 , pp. 802-808
    • Mao, T.K.1    Lian, Z.X.2    Selmi, C.3
  • 170
    • 34547427414 scopus 로고    scopus 로고
    • Altered expression of TLR homolog RP105 on monocytes hypersensitive to LPS in patients with primary biliary cirrhosis
    • Honda Y, Yamagiwa S, Matsuda Y, et al. Altered expression of TLR homolog RP105 on monocytes hypersensitive to LPS in patients with primary biliary cirrhosis. J Hepatol 2007:47:404-11.
    • (2007) J Hepatol , vol.47 , pp. 404-411
    • Honda, Y.1    Yamagiwa, S.2    Matsuda, Y.3
  • 171
    • 20144363210 scopus 로고    scopus 로고
    • Genetic polymorphisms of toll-like receptor 9 influence the immune response to CpG and contribute to hyper-IgM in primary biliary cirrhosis
    • Kikuchi K, Lian ZX, Kimura Y, et al. Genetic polymorphisms of toll-like receptor 9 influence the immune response to CpG and contribute to hyper-IgM in primary biliary cirrhosis. J Autoimmun 2005:24:347- 52.
    • (2005) J Autoimmun , vol.24 , pp. 347-352
    • Kikuchi, K.1    Lian, Z.X.2    Kimura, Y.3
  • 172
    • 14244262923 scopus 로고    scopus 로고
    • Bacterial CpG induces hyper-IgM production in CD27(+) memory B cells in primary biliary cirrhosis
    • Kikuchi K, Lian ZX, Yang GX, et al. Bacterial CpG induces hyper-IgM production in CD27(+) memory B cells in primary biliary cirrhosis. Gastroenterology 2005:128:304-12.
    • (2005) Gastroenterology , vol.128 , pp. 304-312
    • Kikuchi, K.1    Lian, Z.X.2    Yang, G.X.3
  • 173
    • 34247196579 scopus 로고    scopus 로고
    • Biliary epithelial cell antibodies link adaptive and innate immune responses in primary sclerosing cholangitis
    • Karrar A, Broome U, Sodergren T, et al. Biliary epithelial cell antibodies link adaptive and innate immune responses in primary sclerosing cholangitis. Gastroenterology 2007:132:1504-14.
    • (2007) Gastroenterology , vol.132 , pp. 1504-1514
    • Karrar, A.1    Broome, U.2    Sodergren, T.3
  • 174
    • 0037372661 scopus 로고    scopus 로고
    • Inhibition of endotoxin response by e5564, a novel Toll-like receptor 4-directed endotoxin antagonist
    • Mullarkey M, Rose JR, Bristol J, et al. Inhibition of endotoxin response by e5564, a novel Toll-like receptor 4-directed endotoxin antagonist. J Pharmacol Exp Ther 2003:304:1093-102.
    • (2003) J Pharmacol Exp Ther , vol.304 , pp. 1093-1102
    • Mullarkey, M.1    Rose, J.R.2    Bristol, J.3
  • 175
    • 0036954040 scopus 로고    scopus 로고
    • Antagonism of in vivo and ex vivo response to endotoxin by E5564, a synthetic lipid A analogue
    • Rossignol DP, Lynn M. Antagonism of in vivo and ex vivo response to endotoxin by E5564, a synthetic lipid A analogue. J Endotoxin Res 2002:8:483-8.
    • (2002) J Endotoxin Res , vol.8 , pp. 483-488
    • Rossignol, D.P.1    Lynn, M.2
  • 176
    • 20844463064 scopus 로고    scopus 로고
    • A synthetic TLR4 antagonist has anti-inflammatory effects in two murine models of inflammatory bowel disease
    • Fort MM, Mozaffarian A, Stover AG, et al. A synthetic TLR4 antagonist has anti-inflammatory effects in two murine models of inflammatory bowel disease. J Immunol 2005:174:6416-23.
    • (2005) J Immunol , vol.174 , pp. 6416-6423
    • Fort, M.M.1    Mozaffarian, A.2    Stover, A.G.3
  • 177
    • 33645097021 scopus 로고    scopus 로고
    • A novel cyclohexene derivative, ethyl (6fl)-6-[/V-(2-chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene- 1-carboxylate (TAK-242), selectively inhibits toll-like receptor 4-mediated cytokine production through suppression of intracellular signaling
    • li M, Matsunaga N, Hazeki K, et al. A novel cyclohexene derivative, ethyl (6fl)-6-[/V-(2-chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene- 1-carboxylate (TAK-242), selectively inhibits toll-like receptor 4-mediated cytokine production through suppression of intracellular signaling. Mol Pharmacol 2006:69:1288-95.
    • (2006) Mol Pharmacol , vol.69 , pp. 1288-1295
    • li, M.1    Matsunaga, N.2    Hazeki, K.3
  • 178
    • 41149131096 scopus 로고    scopus 로고
    • TAK-242 selectively suppresses Toll-like receptor 4-signaling mediated by the intracellular domain
    • Kawamoto T, li M, Kitazaki T, et al. TAK-242 selectively suppresses Toll-like receptor 4-signaling mediated by the intracellular domain. Eur J Pharmacol 2008:584:40-8.
    • (2008) Eur J Pharmacol , vol.584 , pp. 40-48
    • Kawamoto, T.1    li, M.2    Kitazaki, T.3
  • 179
    • 34548496023 scopus 로고    scopus 로고
    • Therapeutic effects of TAK-242, a novel selective Toll-like receptor 4 signal transduction inhibitor, in mouse endotoxin shock model
    • Sha T, Sunamoto M, Kitazaki T, et al. Therapeutic effects of TAK-242, a novel selective Toll-like receptor 4 signal transduction inhibitor, in mouse endotoxin shock model. Eur J Pharmacol 2007:571:231-9.
    • (2007) Eur J Pharmacol , vol.571 , pp. 231-239
    • Sha, T.1    Sunamoto, M.2    Kitazaki, T.3
  • 180
    • 34249677845 scopus 로고    scopus 로고
    • Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists
    • Kanzler H, Barrat FJ, Hessel EM, et al. Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists. Nat Med 2007:13:552-9.
    • (2007) Nat Med , vol.13 , pp. 552-559
    • Kanzler, H.1    Barrat, F.J.2    Hessel, E.M.3
  • 181
    • 0038651180 scopus 로고    scopus 로고
    • Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: Activation of Toll-like receptor 7
    • Lee J, Chuang TH, Redecke V, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci USA 2003:100:6646-51.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 6646-6651
    • Lee, J.1    Chuang, T.H.2    Redecke, V.3
  • 183
    • 33646591324 scopus 로고    scopus 로고
    • A phase Ha placebo-controlled, double bind trial to determine the safety, tolerability and pk/pd of an oral interferon inducer
    • Pockros P, Tong M, Wright T. A phase Ha placebo-controlled, double bind trial to determine the safety, tolerability and pk/pd of an oral interferon inducer. Gastroenterology 2003:124:76A.
    • (2003) Gastroenterology , vol.124
    • Pockros, P.1    Tong, M.2    Wright, T.3
  • 184
    • 36349031101 scopus 로고    scopus 로고
    • Good science behind hepatitis C virus antiviral drug development: Necessary but not sufficient
    • Pappas SC. Good science behind hepatitis C virus antiviral drug development: necessary but not sufficient. Hepatology 2007:46:1317-8.
    • (2007) Hepatology , vol.46 , pp. 1317-1318
    • Pappas, S.C.1
  • 185
    • 36348931521 scopus 로고    scopus 로고
    • Phase 1B, randomized, double-blind, dose-escalation trial of CPG 10101 in patients with chronic hepatitis C virus
    • McHutchison JG, Bacon BR, Gordon SC, et al. Phase 1B, randomized, double-blind, dose-escalation trial of CPG 10101 in patients with chronic hepatitis C virus. Hepatology 2007:46:1341-9.
    • (2007) Hepatology , vol.46 , pp. 1341-1349
    • McHutchison, J.G.1    Bacon, B.R.2    Gordon, S.C.3
  • 186
    • 20644468617 scopus 로고    scopus 로고
    • Effect of Lactobacillus supplementation with and without arginine on liver damage and bacterial translocation in an acute liver injury model in the rat
    • Adawi D, Kasravi FB, Molin G, et al. Effect of Lactobacillus supplementation with and without arginine on liver damage and bacterial translocation in an acute liver injury model in the rat. Hepatology 1997:25:642-7.
    • (1997) Hepatology , vol.25 , pp. 642-647
    • Adawi, D.1    Kasravi, F.B.2    Molin, G.3
  • 187
    • 34548757869 scopus 로고    scopus 로고
    • Probiotic bacteria prevent hepatic damage and maintain colonic barrier function in a mouse model of sepsis
    • Ewaschuk J, Endersby R, Thiel D, et al. Probiotic bacteria prevent hepatic damage and maintain colonic barrier function in a mouse model of sepsis. Hepatology 2007:46:841-50.
    • (2007) Hepatology , vol.46 , pp. 841-850
    • Ewaschuk, J.1    Endersby, R.2    Thiel, D.3
  • 188
    • 34547657678 scopus 로고    scopus 로고
    • Endotoxin- and D-galactosamine-induced liver injury improved by the administration of Lactobacillus, Bifidobacterium and blueberry
    • Osman N, Adawi D, Ahrne S, et al. Endotoxin- and D-galactosamine-induced liver injury improved by the administration of Lactobacillus, Bifidobacterium and blueberry. Dig Liver Dis 2007:39:849-56.
    • (2007) Dig Liver Dis , vol.39 , pp. 849-856
    • Osman, N.1    Adawi, D.2    Ahrne, S.3
  • 189
    • 0037099390 scopus 로고    scopus 로고
    • Early enteral supply of Lactobacillus and f ber versus selective bowel decontamination: A controlled trial in liver transplant recipients
    • Rayes N, Seehofer D, Hansen S, et al. Early enteral supply of Lactobacillus and f ber versus selective bowel decontamination: a controlled trial in liver transplant recipients. Transplantation 2002:74:123-7.
    • (2002) Transplantation , vol.74 , pp. 123-127
    • Rayes, N.1    Seehofer, D.2    Hansen, S.3
  • 190
    • 11844284850 scopus 로고    scopus 로고
    • Supply of pre- and probiotics reduces bacterial infection rates after liver transplantation - a randomized, double-blind trial
    • Rayes N, Seehofer D, Theruvath T, et al. Supply of pre- and probiotics reduces bacterial infection rates after liver transplantation - a randomized, double-blind trial. Am J Transplant 2005:5:125-30.
    • (2005) Am J Transplant , vol.5 , pp. 125-130
    • Rayes, N.1    Seehofer, D.2    Theruvath, T.3
  • 191
    • 20844440555 scopus 로고    scopus 로고
    • Beneficial effects of a probiotic VSL#3 on parameters of liver dysfunction in chronic liver diseases
    • Loguercio C, Federico A, Tuccillo C, et al. Beneficial effects of a probiotic VSL#3 on parameters of liver dysfunction in chronic liver diseases. J Clin Gastroenterol 2005:39:540-3.
    • (2005) J Clin Gastroenterol , vol.39 , pp. 540-543
    • Loguercio, C.1    Federico, A.2    Tuccillo, C.3
  • 192
    • 0028220726 scopus 로고
    • Lactobacillus feeding reduces endotoxemia and severity of experimental alcoholic liver (disease)
    • Nanji AA, Khettry U, Sadrzadeh SM. Lactobacillus feeding reduces endotoxemia and severity of experimental alcoholic liver (disease). Proc Soc Exp Biol Med 1994:205:243-7.
    • (1994) Proc Soc Exp Biol Med , vol.205 , pp. 243-247
    • Nanji, A.A.1    Khettry, U.2    Sadrzadeh, S.M.3
  • 193
    • 0029069926 scopus 로고
    • Effect of selective bowel decontamination with norfloxacin on spontaneous bacterial peritonitis, translocation, and survival in an animal model of cirrhosis
    • Runyon BA, Borzio M, Young S, et al. Effect of selective bowel decontamination with norfloxacin on spontaneous bacterial peritonitis, translocation, and survival in an animal model of cirrhosis. Hepatology 1995:21:1719-24.
    • (1995) Hepatology , vol.21 , pp. 1719-1724
    • Runyon, B.A.1    Borzio, M.2    Young, S.3
  • 194
    • 13344277344 scopus 로고    scopus 로고
    • Selective intestinal decontamination with norfloxacin reduces bacterial translocation in ascitic cirrhotic rats exposed to hemorrhagic shock
    • Uovet JM, Bartoli R, Planas R, et al. Selective intestinal decontamination with norfloxacin reduces bacterial translocation in ascitic cirrhotic rats exposed to hemorrhagic shock. Hepatology 1996:23:781-7.
    • (1996) Hepatology , vol.23 , pp. 781-787
    • Uovet, J.M.1    Bartoli, R.2    Planas, R.3
  • 195
    • 0036105276 scopus 로고    scopus 로고
    • Failure of Lactobacillus spp. to prevent bacterial translocation in a rat model of experimental cirrhosis
    • Bauer TM, Fernandez J, Navasa M, et al. Failure of Lactobacillus spp. to prevent bacterial translocation in a rat model of experimental cirrhosis. J Hepatol 2002:36:501-6.
    • (2002) J Hepatol , vol.36 , pp. 501-506
    • Bauer, T.M.1    Fernandez, J.2    Navasa, M.3
  • 196
    • 34548487937 scopus 로고    scopus 로고
    • Primary prophylaxis of spontaneous bacterial peritonitis delays hepatorenal syndrome ansd uction survival in cirrhosis
    • Fernandez J, Navasa M, Planas R, et al. Primary prophylaxis of spontaneous bacterial peritonitis delays hepatorenal syndrome ansd uction survival in cirrhosis. Gastroenterology 2007:133:818-24.
    • (2007) Gastroenterology , vol.133 , pp. 818-824
    • Fernandez, J.1    Navasa, M.2    Planas, R.3
  • 197
    • 34548476217 scopus 로고    scopus 로고
    • A pill a day can improve survival in patients with advanced cirrhosis
    • Runyon BA. A pill a day can improve survival in patients with advanced cirrhosis. Gastroenterology 2007:133:1029-31.
    • (2007) Gastroenterology , vol.133 , pp. 1029-1031
    • Runyon, B.A.1


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