Intravascular danger signals guide neutrophils to sites of sterile inflammation

Science

Volumn 330, Issue 6002, 2010, Pages 362-366

  McDonald, Braedon ^a   Pittman, Keir ^a   Menezes, Gustavo B ^a,c   Hirota, Simon A ^b   Slaba, Ingrid ^a   Waterhouse, Christopher C M ^a,b   Beck, Paul L ^b   Muruve, Daniel A ^a,b   Kubes, Paul ^a  

^a UNIVERSITY OF CALGARY   (Canada)

^b UNIVERSITY OF CALGARY   (Canada)

^c FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; ADENOSINE TRIPHOSPHATE; CARRIER PROTEIN; CD11B ANTIGEN; CHEMOKINE RECEPTOR CXCR2; CIAS1 PROTEIN, MOUSE; CXCL2 CHEMOKINE; CXCL2 PROTEIN, MOUSE; FORMYLPEPTIDE RECEPTOR; FPR1 PROTEIN, MOUSE; P2RX7 PROTEIN, MOUSE; PEPTIDE; PURINERGIC P2 RECEPTOR; PURINERGIC P2X7 RECEPTOR;

BLOOD; MOLECULAR ANALYSIS; PEPTIDE; SIGNAL;

ARTICLE; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; INFLAMMATION; KINETICS; LIVER SINUSOID; NEUTROPHIL; PRIORITY JOURNAL; ANIMAL; ASSOCIATION; CELL ADHESION; IMMUNOLOGY; LIVER; LIVER DISEASE; METABOLISM; MICROSCOPY; MICROVASCULATURE; MOUSE; NECROSIS; NEUTROPHIL CHEMOTAXIS; PATHOLOGY; PHYSIOLOGY; PROCEDURES; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM; VASCULARIZATION;

ADENOSINE TRIPHOSPHATE; ANIMALS; CARRIER PROTEINS; CELL ADHESION; CHEMOKINE CXCL2; CHEMOKINES; CHEMOTAXIS, LEUKOCYTE; CUES; ENDOTHELIUM, VASCULAR; INFLAMMATION; KINETICS; LIVER; LIVER DISEASES; MACROPHAGE-1 ANTIGEN; MICE; MICROSCOPY; MICROSCOPY, CONFOCAL; MICROVESSELS; NECROSIS; NEUTROPHIL INFILTRATION; NEUTROPHILS; PEPTIDES; RECEPTORS, FORMYL PEPTIDE; RECEPTORS, INTERLEUKIN-8B; RECEPTORS, PURINERGIC P2; RECEPTORS, PURINERGIC P2X7; SIGNAL TRANSDUCTION;

EID: 77957943307     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1195491     Document Type: Article

References (25)

1. H. Kono, K. L. Rock, Nat. Rev. Immunol. 8, 279 (2008).
2. A. W. Segal, Annu. Rev. Immunol. 23, 197 (2005).
3. M. C. Hyman et al., J. Clin. Invest. 119, 1136 (2009).
4. A. B. Imaeda et al., J. Clin. Invest. 119, 305 (2009).
5. Z. X. Liu, D. Han, B. Gunawan, N. Kaplowitz, Hepatology 43, 1220 (2006).
6. A. Tsung et al., J. Exp. Med. 201, 1135 (2005).
7. Q. Zhang et al., Nature 464, 104 (2010).
8. D. Jiang et al., Nat. Med. 11, 1173 (2005).
9. P. Scaffidi, T. Misteli, M. E. Bianchi, Nature 418, 191 (2002).
10. Y. Shi, J. E. Evans, K. L. Rock, Nature 425, 516 (2003).
11. F. Martinon, V. Pétrilli, A. Mayor, A. Tardivel, J. Tschopp, Nature 440, 237 (2006).
12. C. J. Chen et al., Nat. Med. 13, 851 (2007).
13. Material and methods are available as supporting online material at Science Online.
14. S. Rakoff-Nahoum, J. Paglino, F. Eslami-Varzaneh, S. Edberg, R. Medzhitov, Cell 118, 229 (2004).
15. D. Davalos et al., Nat. Neurosci. 8, 752 (2005).
16. M. R. Elliott et al., Nature 461, 282 (2009).
17. Y. Chen et al., Science 314, 1792 (2006).
18. J. Tschopp, K. Schroder, Nat. Rev. Immunol. 10, 210 (2010).
19. S. S. Iyer et al., Proc. Natl. Acad. Sci. U.S.A. 106, 20388 (2009).
20. H. Kono, D. Karmarkar, Y. Iwakura, K. L. Rock, J. Immunol. 184, 4470 (2010).
21. W. Y. Lee et al., Nat. Immunol. 11, 295 (2010).
22. J. Middleton et al., Cell 91, 385 (1997).
23. B. Heit et al., Nat. Immunol. 9, 743 (2008).
24. C. Nathan, Nat. Rev. Immunol. 6, 173 (2006).
25. We thank C. Badick for excellent technical support. This study was supported by grants from the Canadian Institutes of Health Research and Alberta Innovates (Health Solutions).