Extracellular ATP induces P2X7 receptor activation in mouse Kupffer cells, leading to release of IL-1β, HMGB1, and PGE2, decreased MHC class I expression and necrotic cell death

Biochemical and Biophysical Research Communications

Volumn 458, Issue 4, 2015, Pages 771-776

  Toki, Yusuke ^a   Takenouchi, Takato ^b   Harada, Hitoshi ^c   Tanuma, Sei Ichi ^a   Kitani, Hiroshi ^b   Kojima, Shuji ^a   Tsukimoto, Mitsutoshi ^a  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

^b NATIONAL INSTITUTE OF AGROBIOLOGICAL SCIENCES   (Japan)

^c SUZUKA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

Author keywords

Cell death; Cytokine production; Inflammation; Kupffer cells; P2X7 receptor

Indexed keywords

3 [[5 (2,3 DICHLOROPHENYL) 1H TETRAZOL 1 YL]METHYL]PYRIDINE; ADENOSINE TRIPHOSPHATE; CALCIUM ION; HIGH MOBILITY GROUP B1 PROTEIN; INTERLEUKIN 1BETA; LACTATE DEHYDROGENASE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PROSTAGLANDIN E2; PURINERGIC P2X7 RECEPTOR; HLA ANTIGEN CLASS 1;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; CALCIUM CELL LEVEL; CELL DEATH; CELL VIABILITY; CHANNEL GATING; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOLYSIS; ENZYME PHOSPHORYLATION; ENZYME RELEASE; FLOW CYTOMETRY; IMMUNOBLOTTING; KUPFFER CELL; LIVER DISEASE; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; ANIMAL; C57BL MOUSE; CELL CULTURE; CYTOLOGY; IMMUNOLOGY; INFLAMMATION; NECROSIS;

ADENOSINE TRIPHOSPHATE; ANIMALS; CELLS, CULTURED; DINOPROSTONE; HISTOCOMPATIBILITY ANTIGENS CLASS I; HMGB1 PROTEIN; INFLAMMATION; INTERLEUKIN-1BETA; KUPFFER CELLS; MICE; MICE, INBRED C57BL; NECROSIS; RECEPTORS, PURINERGIC P2X7;

EID: 84925516213     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.02.011     Document Type: Article

References (27)

1. G. Kolios, V. Valatas, and E. Kouroumalis Role of Kupffer cells in the pathogenesis of liver disease World J. Gastroenterol. 12 2006 7413 7420
2. D.L. Laskin, A.M. Pilaro, and S. Ji Potential role of activated macrophages in acetaminophen hepatotoxicity. II. Mechanism of macrophage accumulation and activation Toxicol. Appl. Pharmacol. 86 1986 216 226
3. S.D. Panuganti, F.D. Khan, and C.K. Svensson Enhanced xenobiotic-induced hepatotoxicity and Kupffer cell activation by restraint-induced stress J. Pharmacol. Exp. Ther. 318 2006 26 34
4. V. Thakur, M.R. McMullen, M.T. Pritchard, and L.E. Nagy Regulation of macrophage activation in alcoholic liver disease J. Gastroenterol. Hepatol. 22 Suppl. 1 2007 S53 S56
5. C. Liu, Q. Tao, M. Sun, J.Z. Wu, W. Yang, P. Jian, J. Peng, Y. Hu, C. Liu, and P. Liu Kupffer cells are associated with apoptosis, inflammation and fibrotic effects in hepatic fibrosis in rats Lab. Invest. 90 2010 1805 1816
6. L. Alric, C. Orfila, N. Carrere, M. Beraud, G. Carrera, J.C. Lepert, M. Duffaut, B. Pipy, and J.P. Vinel Reactive oxygen intermediates and eicosanoid production by Kupffer cells and infiltrated macrophages in acute and chronic liver injury induced in rats by CCl4 Inflamm. Res. 49 2000 700 707
7. S.L. Friedman Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury J. Biol. Chem. 275 2000 2247 2250
8. S.W. Luckey, and D.R. Petersen Activation of Kupffer cells during the course of carbon tetrachloride-induced liver injury and fibrosis in rats Exp. Mol. Pathol. 71 2001 226 240
9. J. Lin, J.F. Wu, Q. Zhang, H.W. Zhang, and G.W. Cao Virus-related liver cirrhosis: molecular basis and therapeutic options World J. Gastroenterol. 20 2014 6457 6469
10. G. Burnstock, and J.M. Boeynaems Purinergic signalling and immune cells Purinergic Signal. 10 2014 529 564
11. A. Surprenant, F. Rassendren, E. Kawashima, R.A. North, and G. Buell The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7) Science 272 1996 735 738
12. A. Baroja-Mazo, M. Barbera-Cremades, and P. Pelegrin P2X7 receptor activation impairs exogenous MHC class I oligopeptides presentation in antigen presenting cells PLoS One 8 2013 e70577
13. S.R. Taylor, C.M. Turner, J.I. Elliott, J. McDaid, R. Hewitt, J. Smith, M.C. Pickering, D.L. Whitehouse, H.T. Cook, G. Burnstock, C.D. Pusey, R.J. Unwin, and F.W. Tam P2X7 deficiency attenuates renal injury in experimental glomerulonephritis J. Am. Soc. Nephrol. 20 2009 1275 1281
14. J. Li, D. Liu, H.Z. Ke, R.L. Duncan, and C.H. Turner The P2X7 nucleotide receptor mediates skeletal mechanotransduction J. Biol. Chem. 280 2005 42952 42959
15. R. Hoque, M.A. Sohail, S. Salhanick, A.F. Malik, A. Ghani, S.C. Robson, and W.Z. Mehal P2X7 receptor-mediated purinergic signaling promotes liver injury in acetaminophen hepatotoxicity in mice Am. J. Physiol. Gastrointest. Liver Physiol. 302 2012 G1171 G1179
16. S. Chatterjee, R. Rana, J. Corbett, M.B. Kadiiska, J. Goldstein, and R.P. Mason P2X7 receptor-NADPH oxidase axis mediates protein radical formation and Kupffer cell activation in carbon tetrachloride-mediated steatohepatitis in obese mice Free. Radic. Biol. Med. 52 2012 1666 1679
17. H. Kitani, C. Sakuma, T. Takenouchi, M. Sato, M. Yoshioka, and N. Yamanaka Establishment of c-myc-immortalized Kupffer cell line from a C57BL/6 mouse strain Results Immunol. 4 2014 68 74
18. A. Kawano, M. Tsukimoto, D. Mori, T. Noguchi, H. Harada, T. Takenouchi, H. Kitani, and S. Kojima Regulation of P2X7-dependent inflammatory functions by P2X4 receptor in mouse macrophages Biochem. Biophys. Res. Commun. 420 2012 102 107
19. T. Noguchi, K. Ishii, H. Fukutomi, I. Naguro, A. Matsuzawa, K. Takeda, and H. Ichijo Requirement of reactive oxygen species-dependent activation of ASK1-p38 MAPK pathway for extracellular ATP-induced apoptosis in macrophage J. Biol. Chem. 283 2008 7657 7665
20. R. Auger, I. Motta, K. Benihoud, D.M. Ojcius, and J.M. Kanellopoulos A role for mitogen-activated protein kinase (Erk1/2) activation and non-selective pore formation in P2X7 receptor-mediated thymocyte death J. Biol. Chem. 280 2005 28142 28151
21. J. Amstrup, and I. Novak P2X7 receptor activates extracellular signal-regulated kinases ERK1 and ERK2 independently of Ca2+ influx Biochem. J. 374 2003 51 61
22. K.A. Hogquist, M.A. Nett, E.R. Unanue, and D.D. Chaplin Interleukin 1 is processed and released during apoptosis Proc. Natl. Acad. Sci. U. S. A. 88 1991 8485 8489
23. C.A. Dinarello Blocking IL-1 in systemic inflammation J. Exp. Med. 201 2005 1355 1359
24. D. Ferrari, C. Pizzirani, E. Adinolfi, R.M. Lemoli, A. Curti, M. Idzko, E. Panther, and F. Di Virgilio The P2X7 receptor: a key player in IL-1 processing and release J. Immunol. 176 2006 3877 3883
25. S. Kojima, Y. Negishi, M. Tsukimoto, T. Takenouchi, H. Kitani, and K. Takeda Purinergic signaling via P2X7 receptor mediates IL-1beta production in Kupffer cells exposed to silica nanoparticle Toxicology 321 2014 13 20
26. U. Andersson, D.J. Antoine, and K.J. Tracey The functions of HMGB1 depend on molecular localization and post-translational modifications J. Intern. Med. 276 2014 420 424
27. M. Barbera-Cremades, A. Baroja-Mazo, A.I. Gomez, F. Machado, F. Di Virgilio, and P. Pelegrin P2X7 receptor-stimulation causes fever via PGE2 and IL-1beta release FASEB J. 26 2012 2951 2962