Gut-derived lipopolysaccharide promotes T-cell-mediated hepatitis in mice through toll-like receptor 4

Cancer Prevention Research

Volumn 5, Issue 9, 2012, Pages 1090-1102

  Lin, Yan ^a   Yu, Le Xing ^a   Yan, He Xin ^a   Yang, Wen ^a   Tang, Liang ^a   Zhang, Hui Lu ^a   Liu, Qiong ^a   Zou, Shan Shan ^a   He, Ya Qin ^a   Wang, Chao ^a   Wu, Meng Chao ^a   Wang, Hong Yang ^a,b  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CONCANAVALIN A; ENDOTOXIN; GRANZYME B; LIPOPOLYSACCHARIDE; PERFORIN; TOLL LIKE RECEPTOR 4;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BONE MARROW CELL; CD4+ T LYMPHOCYTE; CELL INFILTRATION; CONTROLLED STUDY; GENE THERAPY; HELPER CELL; IN VITRO STUDY; IN VIVO STUDY; INTESTINE FLORA; LIVER CELL CARCINOMA; LIVER INJURY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE; VIRUS HEPATITIS;

ANIMALS; CARCINOMA, HEPATOCELLULAR; CD4-POSITIVE T-LYMPHOCYTES; DISEASE MODELS, ANIMAL; FLOW CYTOMETRY; HEPATITIS; INTESTINES; LIPOPOLYSACCHARIDES; LIVER NEOPLASMS; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED C57BL; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

EID: 84866180909     PISSN: 19406207     EISSN: 19406215     Source Type: Journal    
DOI: 10.1158/1940-6207.CAPR-11-0364     Document Type: Article

References (36)

1. Farazi PA, DePinho RA. Hepatocellular carcinoma pathogenesis: from genes to environment. Nat Rev Cancer 2006;6:674-87. (Pubitemid 44286000)
2. Yu LX, Yan HX, Liu Q, Yang W, Wu HP, Dong W, et al. Endotoxin accumulation prevents carcinogen-induced apoptosis and promotes liver tumorigenesis in rodents. Hepatology 2010;52:1322-33.
3. Tiegs G, Hentschel J, Wendel A. A T cell-dependent experimental liver injury in mice inducible by concanavalin A. J Clin Invest 1992;90:196-203.
4. Gantner F, Leist M, Lohse AW, Germann PG, Tiegs G. Concanavalin A-induced T-cell-mediated hepatic injury in mice: the role of tumor necrosis factor. Hepatology 1995;21:190-8.
5. Mizuhara H, O'Neill E, Seki N, Ogawa T, Kusunoki C, Otsuka K, et al. T cell activation-associated hepatic injury: mediation by tumor necrosis factors and protection by interleukin 6. J Exp Med 1994;179:1529-37. (Pubitemid 24129570)
6. O'Garra A. Cytokines induce the development of functionally heterogeneous T helper cell subsets. Immunity 1998;8:275-83. (Pubitemid 28188888)
7. Hou J, Schindler U, Henzel WJ, Ho TC, Brasseur M, McKnight SL. An interleukin-4-induced transcription factor: IL-4 Stat. Science 1994;265:1701-6.
8. Zheng W, Flavell RA. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 1997;89:587-96. (Pubitemid 27511769)
9. Szabo SJ, Kim ST, Costa GL, Zhang X, Fathman CG, Glimcher LH. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 2000;100:655-69.
10. Almeida J, Galhenage S, Yu J, Kurtovic J, Riordan SM. Gut flora and bacterial translocation in chronic liver disease. World J Gastroenterol 2006;12:1493-502.
11. Son G, Kremer M, Hines IN. Contribution of gut bacteria to liver pathobiology. Gastroenterol Res Pract 2010;2010. pii: 453563.
12. Racanelli V, Rehermann B. The liver as an immunological organ. Hepatology 2006;43(2 Suppl 1):S54-S62.
13. Schwabe RF, Seki E, Brenner DA. Toll-like receptor signaling in the liver. Gastroenterology 2006;130:1886-900. (Pubitemid 43668871)
14. Nolan JP. The role of intestinal endotoxin in liver injury: a long and evolving history. Hepatology 2010;52:1829-35.
15. Akira S, Takeda K. Toll-like receptor signalling. Nat Rev Immunol 2004;4:499-511. (Pubitemid 38931765)
16. Schnare M, Barton GM, Holt AC, Takeda K, Akira S, Medzhitov R. Toll-like receptors control activation of adaptive immune responses. Nat Immunol 2001;2:947-50. (Pubitemid 32976167)
17. John B, Crispe IN. TLR-4 regulates CD8+ T cell trapping in the liver. J Immunol 2005;175:1643-50. (Pubitemid 41023067)
18. Himmel ME, Hardenberg G, Piccirillo CA, Steiner TS, Levings MK. The role of T-regulatory cells and Toll-like receptors in the pathogenesis of human inflammatory bowel disease. Immunology 2008;125:145-53.
19. Rakoff-Nahoum S, Paglino J, Eslami-Varzaneh F, Edberg S, Medzhitov R. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 2004;118:229-41. (Pubitemid 38962578)
20. Lewis TS, Shapiro PS, Ahn NG. Signal transduction through MAP kinase cascades. Adv Cancer Res 1998;74:49-139. (Pubitemid 28193546)
21. Takeda K, Hayakawa Y, Van KL, Matsuda H, Yagita H, Okumura K. Critical contribution of liver natural killer T cells to a murine model of hepatitis. Proc Natl Acad Sci U S A 2000;97:5498-503. (Pubitemid 30313747)
22. Flad HD, Grage-Griebenow E, Petersen F, Scheuerer B, Brandt E, Baran J, et al. The role of cytokines in monocyte apoptosis. Pathobiology 1999;67:291-3. (Pubitemid 30135926)
23. Yasukawa M, Ohminami H, Arai J, Kasahara Y, Ishida Y, Fujita S. Granule exocytosis, and not the fas/fas ligand system, is the main pathway of cytotoxicity mediated by alloantigen-specific CD4(+) as well as CD8(+) cytotoxic T lymphocytes in humans. Blood 2000;95:2352-5. (Pubitemid 30167735)
24. Pipkin ME, Lieberman J. Delivering the kiss of death: progress on understanding how perforin works. Curr Opin Immunol 2007;19:301-8. (Pubitemid 46687016)
25. Trapani JA, Smyth MJ. Functional significance of the perforin/granzyme cell death pathway. Nat Rev Immunol 2002;2:735-47. (Pubitemid 37328714)
26. Lieberman J. The ABCs of granule-mediated cytotoxicity: new weapons in the arsenal. Nat Rev Immunol 2003;3:361-70. (Pubitemid 37323196)
27. Seki E, Brenner DA. Toll-like receptors and adaptor molecules in liver disease: update. Hepatology 2008;48:322-35. (Pubitemid 351975556)
28. Nolan JP, Leibowitz AI. Endotoxins in liver disease. Gastroenterology 1978;75:765-6.
29. Chan CC, Hwang SJ, Lee FY, Wang SS, Chang FY, Li CP, et al. Prognostic value of plasma endotoxin levels in patients with cirrhosis. Scand J Gastroenterol 1997;32:942-6. (Pubitemid 27382041)
30. Such J, Frances R, Munoz C, Zapater P, Casellas JA, Cifuentes A, et al. Detection and identification of bacterial DNA in patients with cirrhosis and culture-negative, nonneutrocytic ascites. Hepatology 2002;36:135-41. (Pubitemid 34700770)
31. Rao RK, Seth A, Sheth P. Recent advances in alcoholic liver disease I. Role of intestinal permeability and endotoxemia in alcoholic liver disease. Am J Physiol Gastrointest Liver Physiol 2004;286:G881-4. (Pubitemid 38715649)
32. Ewaschuk J, Endersby R, Thiel D, Diaz H, Backer J, Ma M, et al. Probiotic bacteria prevent hepatic damage and maintain colonic barrier function in a mouse model of sepsis. Hepatology 2007;46:841-50. (Pubitemid 47436131)
33. Komai-Koma M, Jones L, Ogg GS, Xu D, Liew FY. TLR2 is expressed on activated T cells as a costimulatory receptor. Proc Natl Acad Sci U S A 2004;101:3029-34. (Pubitemid 38327729)
34. Takeda K, Hayakawa Y, Van KL, Matsuda H, Yagita H, Okumura K. Critical contribution of liver natural killer T cells to a murine model of hepatitis. Proc Natl Acad Sci U S A 2000;97:5498-503. (Pubitemid 30313747)
35. Budhu A, Wang XW. The role of cytokines in hepatocellular carcinoma. J Leukoc Biol 2006;80:1197-213. (Pubitemid 44904957)
36. Nakamoto Y, Guidotti LG, Kuhlen CV, Fowler P, Chisari FV. Immune pathogenesis of hepatocellular carcinoma. J Exp Med 1998;188:341-50. (Pubitemid 28357762)