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Volumn 19, Issue 7, 2013, Pages 859-868

Pathogenesis of chronic viral hepatitis: Differential roles of T cells and NK cells

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE PROTEIN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; HEPATITIS B SURFACE ANTIGEN; HLA A3 ANTIGEN; HLA B57 ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 2; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 1; NATURAL KILLER CELL RECEPTOR; NEUTRALIZING ANTIBODY; STAT1 PROTEIN; STAT4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

EID: 84880276248     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.3251     Document Type: Review
Times cited : (392)

References (165)
  • 1
    • 33645729182 scopus 로고    scopus 로고
    • Immunobiology and pathogenesis of viral hepatitis
    • Guidotti, L.G. & Chisari, F.V. Immunobiology and pathogenesis of viral hepatitis. Annu. Rev. Pathol. 1, 23-61 (2006).
    • (2006) Annu. Rev. Pathol. , vol.1 , pp. 23-61
    • Guidotti, L.G.1    Chisari, F.V.2
  • 2
    • 68849111675 scopus 로고    scopus 로고
    • Hepatitis C virus versus innate and adaptive immune responses: A tale of coevolution and coexistence
    • Rehermann, B. Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence. J. Clin. Invest. 119, 1745-1754 (2009).
    • (2009) J. Clin. Invest. , vol.119 , pp. 1745-1754
    • Rehermann, B.1
  • 3
    • 14944375587 scopus 로고    scopus 로고
    • Immunology of hepatitis B virus and hepatitis C virus infection
    • Rehermann, B. & Nascimbeni, M. Immunology of hepatitis B virus and hepatitis C virus infection. Nat. Rev. Immunol. 5, 215-229 (2005).
    • (2005) Nat. Rev. Immunol. , vol.5 , pp. 215-229
    • Rehermann, B.1    Nascimbeni, M.2
  • 4
    • 0037213545 scopus 로고    scopus 로고
    • CD8+ T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection
    • Thimme, R. et al. CD8+ T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection. J. Virol. 77, 68-76 (2003).
    • (2003) J. Virol. , vol.77 , pp. 68-76
    • Thimme, R.1
  • 5
    • 0038543543 scopus 로고    scopus 로고
    • Memory CD8+ T cells are required for protection from persistent hepatitis C virus infection
    • Shoukry, N.H. et al. Memory CD8+ T cells are required for protection from persistent hepatitis C virus infection. J. Exp. Med. 197, 1645-1655 (2003).
    • (2003) J. Exp. Med. , vol.197 , pp. 1645-1655
    • Shoukry, N.H.1
  • 6
    • 34247117935 scopus 로고    scopus 로고
    • Characterization of hepatitis B virus (HBV)-specific T-cell dysfunction in chronic HBV infection
    • Boni, C. et al. Characterization of hepatitis B virus (HBV)-specific T-cell dysfunction in chronic HBV infection. J. Virol. 81, 4215-4225 (2007).
    • (2007) J. Virol. , vol.81 , pp. 4215-4225
    • Boni, C.1
  • 7
    • 79955112364 scopus 로고    scopus 로고
    • Role of the coinhibitory receptor cytotoxic T lymphocyte antigen-4 on apoptosis-prone CD8 T cells in persistent hepatitis B virus infection
    • Schurich, A. et al. Role of the coinhibitory receptor cytotoxic T lymphocyte antigen-4 on apoptosis-prone CD8 T cells in persistent hepatitis B virus infection. Hepatology 53, 1494-1503 (2011).
    • (2011) Hepatology , vol.53 , pp. 1494-1503
    • Schurich, A.1
  • 8
    • 33947421722 scopus 로고    scopus 로고
    • Dysfunction and functional restoration of HCV-specific CD8 responses in chronic hepatitis C virus infection
    • Penna, A. et al. Dysfunction and functional restoration of HCV-specific CD8 responses in chronic hepatitis C virus infection. Hepatology 45, 588-601 (2007).
    • (2007) Hepatology , vol.45 , pp. 588-601
    • Penna, A.1
  • 9
    • 0037105567 scopus 로고    scopus 로고
    • Impaired effector function of hepatitis C virus-specific CD8+ T cells in chronic hepatitis C virus infection
    • Wedemeyer, H. et al. Impaired effector function of hepatitis C virus-specific CD8+ T cells in chronic hepatitis C virus infection. J. Immunol. 169, 3447-3458 (2002).
    • (2002) J. Immunol. , vol.169 , pp. 3447-3458
    • Wedemeyer, H.1
  • 10
    • 33947407689 scopus 로고    scopus 로고
    • Liver-infiltrating lymphocytes in chronic human hepatitis C virus infection display an exhausted phenotype with high levels of PD-1 and low levels of CD127 expression
    • Radziewicz, H. et al. Liver-infiltrating lymphocytes in chronic human hepatitis C virus infection display an exhausted phenotype with high levels of PD-1 and low levels of CD127 expression. J. Virol. 81, 2545-2553 (2007).
    • (2007) J. Virol. , vol.81 , pp. 2545-2553
    • Radziewicz, H.1
  • 11
    • 78649903057 scopus 로고    scopus 로고
    • Tim-3 expression on PD-1+ HCV-specific human CTLs is associated with viral persistence, and its blockade restores hepatocyte-directed in vitro cytotoxicity
    • McMahan, R.H. et al. Tim-3 expression on PD-1+ HCV-specific human CTLs is associated with viral persistence, and its blockade restores hepatocyte-directed in vitro cytotoxicity. J. Clin. Invest. 120, 4546-4557 (2010).
    • (2010) J. Clin. Invest. , vol.120 , pp. 4546-4557
    • McMahan, R.H.1
  • 12
    • 0028360076 scopus 로고
    • Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells
    • Bertoletti, A. et al. Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells. Nature 369, 407-410 (1994).
    • (1994) Nature , vol.369 , pp. 407-410
    • Bertoletti, A.1
  • 13
    • 0029166085 scopus 로고
    • Hepatitis B virus (HBV) sequence variation of cytotoxic T lymphocyte epitopes is not common in patients with chronic HBV infection
    • Rehermann, B., Pasquinelli, C., Mosier, S.M. & Chisari, F.V. Hepatitis B virus (HBV) sequence variation of cytotoxic T lymphocyte epitopes is not common in patients with chronic HBV infection. J. Clin. Invest. 96, 1527-1534 (1995).
    • (1995) J. Clin. Invest. , vol.96 , pp. 1527-1534
    • Rehermann, B.1    Pasquinelli, C.2    Mosier, S.M.3    Chisari, F.V.4
  • 14
    • 0030671121 scopus 로고    scopus 로고
    • Immunological significance of cytotoxic T lymphocyte epitope variants in patients chronically infected by the hepatitis C virus
    • Chang, K.M. et al. Immunological significance of cytotoxic T lymphocyte epitope variants in patients chronically infected by the hepatitis C virus. J. Clin. Invest. 100, 2376-2385 (1997).
    • (1997) J. Clin. Invest. , vol.100 , pp. 2376-2385
    • Chang, K.M.1
  • 15
    • 34548304730 scopus 로고    scopus 로고
    • Human leukocyte antigen-associated sequence polymorphisms in hepatitis C virus reveal reproducible immune responses and constraints on viral evolution
    • Timm, J. et al. Human leukocyte antigen-associated sequence polymorphisms in hepatitis C virus reveal reproducible immune responses and constraints on viral evolution. Hepatology 46, 339-349 (2007).
    • (2007) Hepatology , vol.46 , pp. 339-349
    • Timm, J.1
  • 16
    • 58749109022 scopus 로고    scopus 로고
    • Hepatitis C virus immune escape via exploitation of a hole in the T cell repertoire
    • Wölfl, M. et al. Hepatitis C virus immune escape via exploitation of a hole in the T cell repertoire. J. Immunol. 181, 6435-6446 (2008).
    • (2008) J. Immunol. , vol.181 , pp. 6435-6446
    • Wölfl, M.1
  • 17
    • 0032754504 scopus 로고    scopus 로고
    • Direct ex vivo analysis of hepatitis B virus-specific CD8+ T cells associated with the control of infection
    • Maini, M.K. et al. Direct ex vivo analysis of hepatitis B virus-specific CD8+ T cells associated with the control of infection. Gastroenterology 117, 1386-1396 (1999).
    • (1999) Gastroenterology , vol.117 , pp. 1386-1396
    • Maini, M.K.1
  • 18
    • 17644444485 scopus 로고    scopus 로고
    • Analysis of successful immune responses in persons infected with hepatitis C virus
    • Lechner, F. et al. Analysis of successful immune responses in persons infected with hepatitis C virus. J. Exp. Med. 191, 1499-1512 (2000).
    • (2000) J. Exp. Med. , vol.191 , pp. 1499-1512
    • Lechner, F.1
  • 19
    • 0029838758 scopus 로고    scopus 로고
    • The hepatitis B virus persists for decades after patients' recovery from acute viral hepatitis despite active maintenance of a cytotoxic T-lymphocyte response
    • Rehermann, B., Ferrari, C., Pasquinelli, C. & Chisari, F.V. The hepatitis B virus persists for decades after patients' recovery from acute viral hepatitis despite active maintenance of a cytotoxic T-lymphocyte response. Nat. Med. 2, 1104-1108 (1996).
    • (1996) Nat. Med. , vol.2 , pp. 1104-1108
    • Rehermann, B.1    Ferrari, C.2    Pasquinelli, C.3    Chisari, F.V.4
  • 20
    • 0142178211 scopus 로고    scopus 로고
    • HCV persistence and immune evasion in the absence of memory T cell help
    • Grakoui, A. et al. HCV persistence and immune evasion in the absence of memory T cell help. Science 302, 659-662 (2003).
    • (2003) Science , vol.302 , pp. 659-662
    • Grakoui, A.1
  • 21
    • 61749103383 scopus 로고    scopus 로고
    • Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27-restricted human immune response
    • Dazert, E. et al. Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27-restricted human immune response. J. Clin. Invest. 119, 376-386 (2009).
    • (2009) J. Clin. Invest. , vol.119 , pp. 376-386
    • Dazert, E.1
  • 22
    • 79251547401 scopus 로고    scopus 로고
    • Spontaneous control of HCV is associated with expression of HLA-B 57 and preservation of targeted epitopes
    • Kim, A.Y. et al. Spontaneous control of HCV is associated with expression of HLA-B 57 and preservation of targeted epitopes. Gastroenterology 140, 686-696.e1 (2011).
    • (2011) Gastroenterology , vol.140
    • Kim, A.Y.1
  • 23
    • 80053566559 scopus 로고    scopus 로고
    • Molecular footprints reveal the impact of the protective HLA-A*03 allele in hepatitis C virus infection
    • Fitzmaurice, K. et al. Molecular footprints reveal the impact of the protective HLA-Ac03 allele in hepatitis C virus infection. Gut 60, 1563-1571 (2011).
    • (2011) Gut , vol.60 , pp. 1563-1571
    • Fitzmaurice, K.1
  • 24
    • 33744494806 scopus 로고    scopus 로고
    • Maintenance of HCV-specific T-cell responses in antibody-deficient patients a decade after early therapy
    • Semmo, N. et al. Maintenance of HCV-specific T-cell responses in antibody-deficient patients a decade after early therapy. Blood 107, 4570-4571 (2006).
    • (2006) Blood , vol.107 , pp. 4570-4571
    • Semmo, N.1
  • 25
    • 0034030136 scopus 로고    scopus 로고
    • Cellular immune responses persist and humoral responses decrease two decades after recovery from a single-source outbreak of hepatitis C
    • Takaki, A. et al. Cellular immune responses persist and humoral responses decrease two decades after recovery from a single-source outbreak of hepatitis C. Nat. Med. 6, 578-582 (2000).
    • (2000) Nat. Med. , vol.6 , pp. 578-582
    • Takaki, A.1
  • 26
    • 33847015308 scopus 로고    scopus 로고
    • Hepatitis C virus continuously escapes from neutralizing antibody and T-cell responses during chronic infection in vivo
    • von Hahn, T. et al. Hepatitis C virus continuously escapes from neutralizing antibody and T-cell responses during chronic infection in vivo. Gastroenterology 132, 667-678 (2007).
    • (2007) Gastroenterology , vol.132 , pp. 667-678
    • Von Hahn, T.1
  • 27
    • 16244385911 scopus 로고    scopus 로고
    • Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection
    • Stoop, J.N. et al. Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection. Hepatology 41, 771-778 (2005).
    • (2005) Hepatology , vol.41 , pp. 771-778
    • Stoop, J.N.1
  • 28
    • 33745323050 scopus 로고    scopus 로고
    • Circulating and liver resident CD4+CD25+ regulatory T cells actively influence the antiviral immune response and disease progression in patients with hepatitis B
    • Xu, D. et al. Circulating and liver resident CD4+CD25+ regulatory T cells actively influence the antiviral immune response and disease progression in patients with hepatitis B. J. Immunol. 177, 739-747 (2006).
    • (2006) J. Immunol. , vol.177 , pp. 739-747
    • Xu, D.1
  • 29
    • 0345017746 scopus 로고    scopus 로고
    • Suppression of HCV-specific T cells without differential hierarchy demonstrated ex vivo in persistent HCV infection
    • Sugimoto, K. et al. Suppression of HCV-specific T cells without differential hierarchy demonstrated ex vivo in persistent HCV infection. Hepatology 38, 1437-1448 (2003).
    • (2003) Hepatology , vol.38 , pp. 1437-1448
    • Sugimoto, K.1
  • 30
    • 51049123791 scopus 로고    scopus 로고
    • Functional skewing of the global CD8 T cell population in chronic hepatitis B virus infection
    • Das, A. et al. Functional skewing of the global CD8 T cell population in chronic hepatitis B virus infection. J. Exp. Med. 205, 2111-2124 (2008).
    • (2008) J. Exp. Med. , vol.205 , pp. 2111-2124
    • Das, A.1
  • 32
    • 77951925447 scopus 로고    scopus 로고
    • Transient CD86 expression on hepatitis C virus-specific CD8+ T cells in acute infection is linked to sufficient IL-2 signaling
    • Radziewicz, H. et al. Transient CD86 expression on hepatitis C virus-specific CD8+ T cells in acute infection is linked to sufficient IL-2 signaling. J. Immunol. 184, 2410-2422 (2010).
    • (2010) J. Immunol. , vol.184 , pp. 2410-2422
    • Radziewicz, H.1
  • 33
    • 84867308365 scopus 로고    scopus 로고
    • IL-10-producing regulatory B cells in the pathogenesis of chronic hepatitis B virus infection
    • Das, A. et al. IL-10-producing regulatory B cells in the pathogenesis of chronic hepatitis B virus infection. J. Immunol. 189, 3925-3935 (2012).
    • (2012) J. Immunol. , vol.189 , pp. 3925-3935
    • Das, A.1
  • 34
    • 2142702915 scopus 로고    scopus 로고
    • Hepatic expansion of a virus-specific regulatory CD8+ T cell population in chronic hepatitis C virus infection
    • Accapezzato, D. et al. Hepatic expansion of a virus-specific regulatory CD8+ T cell population in chronic hepatitis C virus infection. J. Clin. Invest. 113, 963-972 (2004).
    • (2004) J. Clin. Invest. , vol.113 , pp. 963-972
    • Accapezzato, D.1
  • 35
    • 34249787349 scopus 로고    scopus 로고
    • Hepatitis C virus (HCV)-specific CD8+ cells produce transforming growth factor ß that can suppress HCV-specific T-cell responses
    • Alatrakchi, N. et al. Hepatitis C virus (HCV)-specific CD8+ cells produce transforming growth factor ß that can suppress HCV-specific T-cell responses. J. Virol. 81, 5882-5892 (2007).
    • (2007) J. Virol. , vol.81 , pp. 5882-5892
    • Alatrakchi, N.1
  • 36
    • 80053316319 scopus 로고    scopus 로고
    • Human leukocyte antigen B27 selects for rare escape mutations that significantly impair hepatitis C virus replication and require compensatory mutations
    • Neumann-Haefelin, C. et al. Human leukocyte antigen B27 selects for rare escape mutations that significantly impair hepatitis C virus replication and require compensatory mutations. Hepatology 54, 1157-1166 (2011).
    • (2011) Hepatology , vol.54 , pp. 1157-1166
    • Neumann-Haefelin, C.1
  • 37
    • 67449135849 scopus 로고    scopus 로고
    • Chronic antigen stimulation alone is sufficient to drive CD8+ T cell exhaustion
    • Bucks, C.M., Norton, J.A., Boesteanu, A.C., Mueller, Y.M. & Katsikis, P.D. Chronic antigen stimulation alone is sufficient to drive CD8+ T cell exhaustion. J. Immunol. 182, 6697-6708 (2009).
    • (2009) J. Immunol. , vol.182 , pp. 6697-6708
    • Bucks, C.M.1    Norton, J.A.2    Boesteanu, A.C.3    Mueller, Y.M.4    Katsikis, P.D.5
  • 38
    • 66649114758 scopus 로고    scopus 로고
    • High antigen levels are the cause of T cell exhaustion during chronic viral infection
    • Mueller, S.N. & Ahmed, R. High antigen levels are the cause of T cell exhaustion during chronic viral infection. Proc. Natl. Acad. Sci. USA 106, 8623-8628 (2009).
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 8623-8628
    • Mueller, S.N.1    Ahmed, R.2
  • 39
    • 58849105469 scopus 로고    scopus 로고
    • High-programmed death-1 levels on hepatitis C virus-specific T cells during acute infection are associated with viral persistence and require preservation of cognate antigen during chronic infection
    • Rutebemberwa, A. et al. High-programmed death-1 levels on hepatitis C virus-specific T cells during acute infection are associated with viral persistence and require preservation of cognate antigen during chronic infection. J. Immunol. 181, 8215-8225 (2008).
    • (2008) J. Immunol. , vol.181 , pp. 8215-8225
    • Rutebemberwa, A.1
  • 40
    • 0023764301 scopus 로고
    • Human T cell response to the surface antigen of hepatitis B virus (HBsAg). Endosomal and nonendosomal processing pathways are accessible to both endogenous and exogenous antigen
    • Jin, Y., Shih, W.K. & Berkower, I. Human T cell response to the surface antigen of hepatitis B virus (HBsAg). Endosomal and nonendosomal processing pathways are accessible to both endogenous and exogenous antigen. J. Exp. Med. 168, 293-306 (1988).
    • (1988) J. Exp. Med. , vol.168 , pp. 293-306
    • Jin, Y.1    Shih, W.K.2    Berkower, I.3
  • 41
    • 84866705034 scopus 로고    scopus 로고
    • Restored function of HBV-specific T cells after long-term effective therapy with nucleos(t)ide analogues
    • Boni, C. et al. Restored function of HBV-specific T cells after long-term effective therapy with nucleos(t)ide analogues. Gastroenterology 143, 963-973 e9 (2012).
    • (2012) Gastroenterology , vol.143
    • Boni, C.1
  • 42
    • 77954674575 scopus 로고    scopus 로고
    • Coexpression of PD-1, 2B4, CD160 and KLRG1 on exhausted HCV-specific CD8+ T cells is linked to antigen recognition and T cell differentiation
    • Bengsch, B. et al. Coexpression of PD-1, 2B4, CD160 and KLRG1 on exhausted HCV-specific CD8+ T cells is linked to antigen recognition and T cell differentiation. PLoS Pathog. 6, e1000947 (2010).
    • (2010) PLoS Pathog. , vol.6
    • Bengsch, B.1
  • 43
    • 61449181280 scopus 로고    scopus 로고
    • Synergistic reversal of intrahepatic HCV-specific CD8 T cell exhaustion by combined PD-1/CTLA-4 blockade
    • Nakamoto, N. et al. Synergistic reversal of intrahepatic HCV-specific CD8 T cell exhaustion by combined PD-1/CTLA-4 blockade. PLoS Pathog. 5, e1000313 (2009).
    • (2009) PLoS Pathog. , vol.5
    • Nakamoto, N.1
  • 44
    • 32544459770 scopus 로고    scopus 로고
    • Restoring function in exhausted CD8 T cells during chronic viral infection
    • Barber, D.L. et al. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 439, 682-687 (2006).
    • (2006) Nature , vol.439 , pp. 682-687
    • Barber, D.L.1
  • 45
    • 69449091993 scopus 로고    scopus 로고
    • Negative immune regulator Tim-3 is overexpressed on T cells in hepatitis C virus infection and its blockade rescues dysfunctional CD4+ and CD8+ T cells
    • Golden-Mason, L. et al. Negative immune regulator Tim-3 is overexpressed on T cells in hepatitis C virus infection and its blockade rescues dysfunctional CD4+ and CD8+ T cells. J. Virol. 83, 9122-9130 (2009).
    • (2009) J. Virol. , vol.83 , pp. 9122-9130
    • Golden-Mason, L.1
  • 46
    • 78649625973 scopus 로고    scopus 로고
    • The immunoregulatory role of CD244 in chronic hepatitis B infection and its inhibitory potential on virus-specific CD8+ T-cell function
    • Raziorrouh, B. et al. The immunoregulatory role of CD244 in chronic hepatitis B infection and its inhibitory potential on virus-specific CD8+ T-cell function. Hepatology 52, 1934-1947 (2010).
    • (2010) Hepatology , vol.52 , pp. 1934-1947
    • Raziorrouh, B.1
  • 47
    • 79958076040 scopus 로고    scopus 로고
    • Dual function of the NK cell receptor 2B4 (CD244) in the regulation of HCV-specific CD8+ T cells
    • Schlaphoff, V. et al. Dual function of the NK cell receptor 2B4 (CD244) in the regulation of HCV-specific CD8+ T cells. PLoS Pathog. 7, e1002045 (2011).
    • (2011) PLoS Pathog. , vol.7
    • Schlaphoff, V.1
  • 48
    • 57849168934 scopus 로고    scopus 로고
    • Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection
    • Blackburn, S.D. et al. Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection. Nat. Immunol. 10, 29-37 (2009).
    • (2009) Nat. Immunol. , vol.10 , pp. 29-37
    • Blackburn, S.D.1
  • 49
    • 33748098860 scopus 로고    scopus 로고
    • PD-L1 is induced in hepatocytes by viral infection and by interferon-A and - And mediates T cell apoptosis
    • Mühlbauer, M. et al. PD-L1 is induced in hepatocytes by viral infection and by interferon-a and - and mediates T cell apoptosis. J. Hepatol. 45, 520-528 (2006).
    • (2006) J. Hepatol. , vol.45 , pp. 520-528
    • Mühlbauer, M.1
  • 50
    • 0037815272 scopus 로고    scopus 로고
    • PD-1 inhibits antiviral immunity at the effector phase in the liver
    • Iwai, Y., Terawaki, S., Ikegawa, M., Okazaki, T. & Honjo, T. PD-1 inhibits antiviral immunity at the effector phase in the liver. J. Exp. Med. 198, 39-50 (2003).
    • (2003) J. Exp. Med. , vol.198 , pp. 39-50
    • Iwai, Y.1    Terawaki, S.2    Ikegawa, M.3    Okazaki, T.4    Honjo, T.5
  • 51
    • 33751000216 scopus 로고    scopus 로고
    • In vivo immune modulatory activity of hepatic stellate cells in mice
    • Chen, C.H. et al. In vivo immune modulatory activity of hepatic stellate cells in mice. Hepatology 44, 1171-1181 (2006).
    • (2006) Hepatology , vol.44 , pp. 1171-1181
    • Chen, C.H.1
  • 52
    • 22544479154 scopus 로고    scopus 로고
    • Oscillating CD8+ T cell effector functions after antigen recognition in the liver
    • Isogawa, M., Furuichi, Y. & Chisari, F.V. Oscillating CD8+ T cell effector functions after antigen recognition in the liver. Immunity 23, 53-63 (2005).
    • (2005) Immunity , vol.23 , pp. 53-63
    • Isogawa, M.1    Furuichi, Y.2    Chisari, F.V.3
  • 53
    • 84872932013 scopus 로고    scopus 로고
    • Intrahepatic expression of programmed death-1 and its ligands in patients with HBV-related acute-on-chronic liver failure
    • Cao, D. et al. Intrahepatic expression of programmed death-1 and its ligands in patients with HBV-related acute-on-chronic liver failure. Inflammation 36, 110-120 (2013).
    • (2013) Inflammation , vol.36 , pp. 110-120
    • Cao, D.1
  • 54
    • 79956077563 scopus 로고    scopus 로고
    • T cell exhaustion
    • Wherry, E.J. T cell exhaustion. Nat. Immunol. 12, 492-499 (2011).
    • (2011) Nat. Immunol. , vol.12 , pp. 492-499
    • Wherry, E.J.1
  • 55
    • 33748641378 scopus 로고    scopus 로고
    • Role of Bim in regulating CD8+ T-cell responses during chronic viral infection
    • Grayson, J.M., Weant, A.E., Holbrook, B.C. & Hildeman, D. Role of Bim in regulating CD8+ T-cell responses during chronic viral infection. J. Virol. 80, 8627-8638 (2006).
    • (2006) J. Virol. , vol.80 , pp. 8627-8638
    • Grayson, J.M.1    Weant, A.E.2    Holbrook, B.C.3    Hildeman, D.4
  • 56
    • 43049112084 scopus 로고    scopus 로고
    • Bim-mediated deletion of antigen-specific CD8 T cells in patients unable to control HBV infection
    • Lopes, A.R. et al. Bim-mediated deletion of antigen-specific CD8 T cells in patients unable to control HBV infection. J. Clin. Invest. 118, 1835-1845 (2008).
    • (2008) J. Clin. Invest. , vol.118 , pp. 1835-1845
    • Lopes, A.R.1
  • 57
    • 85027929950 scopus 로고    scopus 로고
    • Persistent hepatitis C virus (HCV) infection impairs HCV-specific cytotoxic T cell reactivity through Mcl-1/Bim imbalance due to CD127 down-regulation
    • Larrubia, J.R. et al. Persistent hepatitis C virus (HCV) infection impairs HCV-specific cytotoxic T cell reactivity through Mcl-1/Bim imbalance due to CD127 down-regulation. J. Viral Hepat. 20, 85-94 (2013).
    • (2013) J. Viral Hepat. , vol.20 , pp. 85-94
    • Larrubia, J.R.1
  • 58
    • 84869880461 scopus 로고    scopus 로고
    • Combined blockade of programmed death-1 and activation of CD137 increase responses of human liver T cells against HBV, but not HCV
    • Fisicaro, P. et al. Combined blockade of programmed death-1 and activation of CD137 increase responses of human liver T cells against HBV, but not HCV. Gastroenterology 143, 1576-1585e.4 (2012).
    • (2012) Gastroenterology , vol.143
    • Fisicaro, P.1
  • 59
    • 44649188658 scopus 로고    scopus 로고
    • Functional restoration of HCV-specific CD8 T cells by PD-1 blockade is defined by PD-1 expression and compartmentalization
    • 1937e1-1932
    • Nakamoto, N. et al. Functional restoration of HCV-specific CD8 T cells by PD-1 blockade is defined by PD-1 expression and compartmentalization. Gastroenterology 134, 1927-1937, 1937.e1-2 (2008).
    • (2008) Gastroenterology , vol.134 , pp. 1927-1937
    • Nakamoto, N.1
  • 60
    • 33744460201 scopus 로고    scopus 로고
    • Foxp3+CD4+CD25+ T cells control virus-specific memory T cells in chimpanzees that recovered from hepatitis C
    • Manigold, T. et al. Foxp3+CD4+CD25+ T cells control virus-specific memory T cells in chimpanzees that recovered from hepatitis C. Blood 107, 4424-4432 (2006).
    • (2006) Blood , vol.107 , pp. 4424-4432
    • Manigold, T.1
  • 61
    • 78651225310 scopus 로고    scopus 로고
    • Blockade of immunosuppressive cytokines restores NK cell antiviral function in chronic hepatitis B virus infection
    • Peppa, D. et al. Blockade of immunosuppressive cytokines restores NK cell antiviral function in chronic hepatitis B virus infection. PLoS Pathog. 6, e1001227 (2010).
    • (2010) PLoS Pathog. , vol.6
    • Peppa, D.1
  • 62
    • 33750826035 scopus 로고    scopus 로고
    • Hepatitis C virus (HCV) core protein-induced, monocyte-mediated mechanisms of reduced IFN-A and plasmacytoid dendritic cell loss in chronic HCV infection
    • Dolganiuc, A. et al. Hepatitis C virus (HCV) core protein-induced, monocyte-mediated mechanisms of reduced IFN-a and plasmacytoid dendritic cell loss in chronic HCV infection. J. Immunol. 177, 6758-6768 (2006).
    • (2006) J. Immunol. , vol.177 , pp. 6758-6768
    • Dolganiuc, A.1
  • 63
    • 38749146900 scopus 로고    scopus 로고
    • TLR-dependent cross talk between human Kupffer cells and NK cells
    • Tu, Z. et al. TLR-dependent cross talk between human Kupffer cells and NK cells. J. Exp. Med. 205, 233-244 (2008).
    • (2008) J. Exp. Med. , vol.205 , pp. 233-244
    • Tu, Z.1
  • 64
    • 0344737658 scopus 로고    scopus 로고
    • IL-10 regulates plasmacytoid dendritic cell response to CpG-containing immunostimulatory sequences
    • Duramad, O. et al. IL-10 regulates plasmacytoid dendritic cell response to CpG-containing immunostimulatory sequences. Blood 102, 4487-4492 (2003).
    • (2003) Blood , vol.102 , pp. 4487-4492
    • Duramad, O.1
  • 65
    • 0032055224 scopus 로고    scopus 로고
    • Inhibitory and stimulatory effects of IL-10 on human CD8+ T cells
    • Groux, H., Bigler, M., de Vries, J.E. & Roncarolo, M.G. Inhibitory and stimulatory effects of IL-10 on human CD8+ T cells. J. Immunol. 160, 3188-3193 (1998).
    • (1998) J. Immunol. , vol.160 , pp. 3188-3193
    • Groux, H.1    Bigler, M.2    De Vries, J.E.3    Roncarolo, M.G.4
  • 66
    • 84870908918 scopus 로고    scopus 로고
    • Dendritic cells, regulatory T cells and the pathogenesis of chronic hepatitis C
    • Losikoff, P.T., Self, A.A. & Gregory, S.H. Dendritic cells, regulatory T cells and the pathogenesis of chronic hepatitis C. Virulence 3, 610-620 (2012).
    • (2012) Virulence , vol.3 , pp. 610-620
    • Losikoff, P.T.1    Self, A.A.2    Gregory, S.H.3
  • 67
    • 21344442371 scopus 로고    scopus 로고
    • Comprehensive analyses of CD8+ T cell responses during longitudinal study of acute human hepatitis C
    • Cox, A.L. et al. Comprehensive analyses of CD8+ T cell responses during longitudinal study of acute human hepatitis C. Hepatology 42, 104-112 (2005).
    • (2005) Hepatology , vol.42 , pp. 104-112
    • Cox, A.L.1
  • 68
    • 80655142505 scopus 로고    scopus 로고
    • Transmission of clonal hepatitis C virus genomes reveals the dominant but transitory role of CD8+ T cells in early viral evolution
    • Callendret, B. et al. Transmission of clonal hepatitis C virus genomes reveals the dominant but transitory role of CD8+ T cells in early viral evolution. J. Virol. 85, 11833-11845 (2011).
    • (2011) J. Virol. , vol.85 , pp. 11833-11845
    • Callendret, B.1
  • 69
    • 84855485734 scopus 로고    scopus 로고
    • Antigen-specific CD4 T-cell help rescues exhausted CD8 T cells during chronic viral infection
    • Aubert, R.D. et al. Antigen-specific CD4 T-cell help rescues exhausted CD8 T cells during chronic viral infection. Proc. Natl. Acad. Sci. USA 108, 21182-21187 (2011).
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 21182-21187
    • Aubert, R.D.1
  • 70
    • 78650583401 scopus 로고    scopus 로고
    • Role of antigen persistence and dose for CD4+ T-cell exhaustion and recovery
    • Han, S., Asoyan, A., Rabenstein, H., Nakano, N. & Obst, R. Role of antigen persistence and dose for CD4+ T-cell exhaustion and recovery. Proc. Natl. Acad. Sci. USA 107, 20453-20458 (2010).
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 20453-20458
    • Han, S.1    Asoyan, A.2    Rabenstein, H.3    Nakano, N.4    Obst, R.5
  • 71
    • 75449101959 scopus 로고    scopus 로고
    • Selection-driven immune escape is not a significant factor in the failure of CD4 T cell responses in persistent hepatitis C virus infection
    • Fuller, M.J. et al. Selection-driven immune escape is not a significant factor in the failure of CD4 T cell responses in persistent hepatitis C virus infection. Hepatology 51, 378-387 (2010).
    • (2010) Hepatology , vol.51 , pp. 378-387
    • Fuller, M.J.1
  • 72
    • 0031937330 scopus 로고    scopus 로고
    • Resident human hepatic lymphocytes are phenotypically different from circulating lymphocytes
    • Norris, S. et al. Resident human hepatic lymphocytes are phenotypically different from circulating lymphocytes. J. Hepatol. 28, 84-90 (1998).
    • (1998) J. Hepatol. , vol.28 , pp. 84-90
    • Norris, S.1
  • 73
    • 68049142973 scopus 로고    scopus 로고
    • Fine characterization of intrahepatic NK cells expressing natural killer receptors in chronic hepatitis B and C
    • Bonorino, P. et al. Fine characterization of intrahepatic NK cells expressing natural killer receptors in chronic hepatitis B and C. J. Hepatol. 51, 458-467 (2009).
    • (2009) J. Hepatol. , vol.51 , pp. 458-467
    • Bonorino, P.1
  • 74
    • 69249113887 scopus 로고    scopus 로고
    • Natural killer cell functional dichotomy in chronic hepatitis B and chronic hepatitis C virus infections
    • 1160e1-1167
    • Oliviero, B. et al. Natural killer cell functional dichotomy in chronic hepatitis B and chronic hepatitis C virus infections. Gastroenterology 137, 1151-1160, 1160.e1-7 (2009).
    • (2009) Gastroenterology , vol.137 , pp. 1151-1160
    • Oliviero, B.1
  • 75
    • 33645231470 scopus 로고    scopus 로고
    • Decreased NK cell frequency in chronic hepatitis C does not affect ex vivo cytolytic killing
    • Morishima, C. et al. Decreased NK cell frequency in chronic hepatitis C does not affect ex vivo cytolytic killing. Hepatology 43, 573-580 (2006).
    • (2006) Hepatology , vol.43 , pp. 573-580
    • Morishima, C.1
  • 76
    • 35748950110 scopus 로고    scopus 로고
    • The trafficking of natural killer cells
    • Grégoire, C. et al. The trafficking of natural killer cells. Immunol. Rev. 220, 169-182 (2007).
    • (2007) Immunol. Rev. , vol.220 , pp. 169-182
    • Grégoire, C.1
  • 77
    • 78449275107 scopus 로고    scopus 로고
    • Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses
    • Paust, S. et al. Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses. Nat. Immunol. 11, 1127-1135 (2010).
    • (2010) Nat. Immunol. , vol.11 , pp. 1127-1135
    • Paust, S.1
  • 78
    • 33645989497 scopus 로고    scopus 로고
    • T cell-and B cell-independent adaptive immunity mediated by natural killer cells
    • O'Leary, J.G., Goodarzi, M., Drayton, D.L. & von Andrian, U.H. T cell-and B cell-independent adaptive immunity mediated by natural killer cells. Nat. Immunol. 7, 507-516 (2006).
    • (2006) Nat. Immunol. , vol.7 , pp. 507-516
    • O'Leary, J.G.1    Goodarzi, M.2    Drayton, D.L.3    Von Andrian, U.H.4
  • 79
    • 33646810822 scopus 로고    scopus 로고
    • Surface expression and cytolytic function of natural killer cell receptors is altered in chronic hepatitis C
    • Nattermann, J. et al. Surface expression and cytolytic function of natural killer cell receptors is altered in chronic hepatitis C. Gut 55, 869-877 (2006).
    • (2006) Gut , vol.55 , pp. 869-877
    • Nattermann, J.1
  • 80
    • 84865542942 scopus 로고    scopus 로고
    • Impaired intrahepatic natural killer cell cytotoxic function in chronic hepatitis C virus infection
    • Varchetta, S. et al. Impaired intrahepatic natural killer cell cytotoxic function in chronic hepatitis C virus infection. Hepatology 56, 841-849 (2012).
    • (2012) Hepatology , vol.56 , pp. 841-849
    • Varchetta, S.1
  • 81
    • 72549104093 scopus 로고    scopus 로고
    • Natural killer cells are polarized toward cytotoxicity in chronic hepatitis C in an interferon-A-dependent manner
    • e1-2
    • Ahlenstiel, G. et al. Natural killer cells are polarized toward cytotoxicity in chronic hepatitis C in an interferon-a-dependent manner. Gastroenterology 138, 325-335.e1-2 (2010).
    • (2010) Gastroenterology , vol.138 , pp. 325-335
    • Ahlenstiel, G.1
  • 82
    • 33947714963 scopus 로고    scopus 로고
    • Increased natural cytotoxicity receptor expression and relevant IL-10 production in NK cells from chronically infected viremic HCV patients
    • De Maria, A. et al. Increased natural cytotoxicity receptor expression and relevant IL-10 production in NK cells from chronically infected viremic HCV patients. Eur. J. Immunol. 37, 445-455 (2007).
    • (2007) Eur. J. Immunol. , vol.37 , pp. 445-455
    • De Maria, A.1
  • 83
    • 78751582170 scopus 로고    scopus 로고
    • Viral load reduction improves activation and function of natural killer cells in patients with chronic hepatitis B
    • Tjwa, E.T., van Oord, G.W., Hegmans, J.P., Janssen, H.L. & Woltman, A.M. Viral load reduction improves activation and function of natural killer cells in patients with chronic hepatitis B. J. Hepatol. 54, 209-218 (2011).
    • (2011) J. Hepatol. , vol.54 , pp. 209-218
    • Tjwa, E.T.1    Van Oord, G.W.2    Hegmans, J.P.3    Janssen, H.L.4    Woltman, A.M.5
  • 84
    • 77952127743 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells sense hepatitis C virus-infected cells, produce interferon, and inhibit infection
    • Takahashi, K. et al. Plasmacytoid dendritic cells sense hepatitis C virus-infected cells, produce interferon, and inhibit infection. Proc. Natl. Acad. Sci. USA 107, 7431-7436 (2010).
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 7431-7436
    • Takahashi, K.1
  • 85
    • 84881522909 scopus 로고    scopus 로고
    • Innate immune tolerance and the role of Kupffer cells in differential responses to interferon therapy among patients with HCV genotype 1 infection
    • Lau, D.T. et al. innate immune tolerance and the role of Kupffer cells in differential responses to interferon therapy among patients with HCV genotype 1 infection. Gastroenterology 144, 402-413.e12 (2012).
    • (2012) Gastroenterology , vol.144
    • Lau, D.T.1
  • 86
    • 0034232047 scopus 로고    scopus 로고
    • Interferon a/ß-mediated inhibition and promotion of interferon gamma: STAT1 resolves a paradox
    • Nguyen, K.B. et al. Interferon a/ß-mediated inhibition and promotion of interferon gamma: STAT1 resolves a paradox. Nat. Immunol. 1, 70-76 (2000).
    • (2000) Nat. Immunol. , vol.1 , pp. 70-76
    • Nguyen, K.B.1
  • 87
    • 34948870247 scopus 로고    scopus 로고
    • High basal STAT4 balanced by STAT1 induction to control type 1 interferon effects in natural killer cells
    • Miyagi, T. et al. High basal STAT4 balanced by STAT1 induction to control type 1 interferon effects in natural killer cells. J. Exp. Med. 204, 2383-2396 (2007).
    • (2007) J. Exp. Med. , vol.204 , pp. 2383-2396
    • Miyagi, T.1
  • 88
    • 84155180827 scopus 로고    scopus 로고
    • Early changes in interferon signaling define natural killer cell response and refractoriness to interferon-based therapy of hepatitis C patients
    • Edlich, B. et al. Early changes in interferon signaling define natural killer cell response and refractoriness to interferon-based therapy of hepatitis C patients. Hepatology 55, 39-48 (2012).
    • (2012) Hepatology , vol.55 , pp. 39-48
    • Edlich, B.1
  • 89
    • 77955848019 scopus 로고    scopus 로고
    • Altered interferon-A-signaling in natural killer cells from patients with chronic hepatitis C virus infection
    • Miyagi, T. et al. Altered interferon-a-signaling in natural killer cells from patients with chronic hepatitis C virus infection. J. Hepatol. 53, 424-430 (2010).
    • (2010) J. Hepatol. , vol.53 , pp. 424-430
    • Miyagi, T.1
  • 90
    • 80053593363 scopus 로고    scopus 로고
    • Early changes in natural killer cell function indicate virologic response to interferon therapy for hepatitis C
    • 1239e1-2
    • Ahlenstiel, G. et al. Early changes in natural killer cell function indicate virologic response to interferon therapy for hepatitis C. Gastroenterology 141, 1231-1239, 1239.e1-2 (2011).
    • (2011) Gastroenterology , vol.141 , pp. 1231-1239
    • Ahlenstiel, G.1
  • 91
    • 80053152866 scopus 로고    scopus 로고
    • Activating NK cell receptor expression/function (NKp30, NKp46, DNAM-1) during chronic viraemic HCV infection is associated with the outcome of combined treatment
    • Bozzano, F. et al. Activating NK cell receptor expression/function (NKp30, NKp46, DNAM-1) during chronic viraemic HCV infection is associated with the outcome of combined treatment. Eur. J. Immunol. 41, 2905-2914 (2011).
    • (2011) Eur. J. Immunol. , vol.41 , pp. 2905-2914
    • Bozzano, F.1
  • 92
    • 84879140583 scopus 로고    scopus 로고
    • Natural killer cell dynamic profile is associated with treatment outcome in patients with chronic HCV infection
    • Published Online 14 March 2013
    • Oliviero, B. et al. Natural killer cell dynamic profile is associated with treatment outcome in patients with chronic HCV infection. J. Hepatol. published online, http://dx.doi.org/10.1016/j.jhep.2013.03.003 (14 March 2013).
    • J. Hepatol.
    • Oliviero, B.1
  • 93
    • 33747059871 scopus 로고    scopus 로고
    • Global transcriptional response to interferon is a determinant of HCV treatment outcome and is modified by race
    • He, X.S. et al. Global transcriptional response to interferon is a determinant of HCV treatment outcome and is modified by race. Hepatology 44, 352-359 (2006).
    • (2006) Hepatology , vol.44 , pp. 352-359
    • He, X.S.1
  • 94
    • 84862777615 scopus 로고    scopus 로고
    • Hepatic cell-type specific gene expression better predicts HCV treatment outcome than IL28B genotype
    • McGilvray, I. et al. Hepatic cell-type specific gene expression better predicts HCV treatment outcome than IL28B genotype. Gastroenterology 142, 1122-1131.e1 (2012).
    • (2012) Gastroenterology , vol.142
    • McGilvray, I.1
  • 95
    • 44349109098 scopus 로고    scopus 로고
    • Interferon signaling and treatment outcome in chronic hepatitis C
    • Sarasin-Filipowicz, M. et al. Interferon signaling and treatment outcome in chronic hepatitis C. Proc. Natl. Acad. Sci. USA 105, 7034-7039 (2008).
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 7034-7039
    • Sarasin-Filipowicz, M.1
  • 96
    • 70349292099 scopus 로고    scopus 로고
    • Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
    • Ge, D. et al. Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature 461, 399-401 (2009).
    • (2009) Nature , vol.461 , pp. 399-401
    • Ge, D.1
  • 97
    • 70349533037 scopus 로고    scopus 로고
    • Genome-wide association of IL28B with response to pegylated interferon-A and ribavirin therapy for chronic hepatitis C
    • Tanaka, Y. et al. Genome-wide association of IL28B with response to pegylated interferon-a and ribavirin therapy for chronic hepatitis C. Nat. Genet. 41, 1105-1109 (2009).
    • (2009) Nat. Genet. , vol.41 , pp. 1105-1109
    • Tanaka, Y.1
  • 98
    • 70349548852 scopus 로고    scopus 로고
    • IL28B is associated with response to chronic hepatitis C interferon-A and ribavirin therapy
    • Suppiah, V. et al. IL28B is associated with response to chronic hepatitis C interferon-a and ribavirin therapy. Nat. Genet. 41, 1100-1104 (2009).
    • (2009) Nat. Genet. , vol.41 , pp. 1100-1104
    • Suppiah, V.1
  • 99
    • 84873083416 scopus 로고    scopus 로고
    • A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus
    • Prokunina-Olsson, L. et al. A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus. Nat. Genet. 45, 164-171 (2013).
    • (2013) Nat. Genet. , vol.45 , pp. 164-171
    • Prokunina-Olsson, L.1
  • 100
    • 80055038932 scopus 로고    scopus 로고
    • Natural killer inhibitory receptor expression associated with treatment failure and interleukin-28B genotype in patients with chronic hepatitis C
    • Golden-Mason, L. et al. Natural killer inhibitory receptor expression associated with treatment failure and interleukin-28B genotype in patients with chronic hepatitis C. Hepatology 54, 1559-1569 (2011).
    • (2011) Hepatology , vol.54 , pp. 1559-1569
    • Golden-Mason, L.1
  • 101
    • 0027453541 scopus 로고
    • Mechanisms of class i restricted immunopathology. A transgenic mouse model of fulminant hepatitis
    • Ando, K. et al. Mechanisms of class I restricted immunopathology. A transgenic mouse model of fulminant hepatitis. J. Exp. Med. 178, 1541-1554 (1993).
    • (1993) J. Exp. Med. , vol.178 , pp. 1541-1554
    • Ando, K.1
  • 102
    • 0030997139 scopus 로고    scopus 로고
    • Interleukin-12 inhibits hepatitis B virus replication in transgenic mice
    • Cavanaugh, V.J., Guidotti, L.G. & Chisari, F.V. Interleukin-12 inhibits hepatitis B virus replication in transgenic mice. J. Virol. 71, 3236-3243 (1997).
    • (1997) J. Virol. , vol.71 , pp. 3236-3243
    • Cavanaugh, V.J.1    Guidotti, L.G.2    Chisari, F.V.3
  • 103
    • 0032889274 scopus 로고    scopus 로고
    • Hepatitis B virus RNA-binding proteins associated with cytokine-induced clearance of viral RNA from the liver of transgenic mice
    • Heise, T., Guidotti, L.G., Cavanaugh, V.J. & Chisari, F.V. Hepatitis B virus RNA-binding proteins associated with cytokine-induced clearance of viral RNA from the liver of transgenic mice. J. Virol. 73, 474-481 (1999).
    • (1999) J. Virol. , vol.73 , pp. 474-481
    • Heise, T.1    Guidotti, L.G.2    Cavanaugh, V.J.3    Chisari, F.V.4
  • 104
    • 0034948064 scopus 로고    scopus 로고
    • Characterization of nuclear RNases that cleave hepatitis B virus RNA near the La protein binding site
    • Heise, T., Guidotti, L.G. & Chisari, F.V. Characterization of nuclear RNases that cleave hepatitis B virus RNA near the La protein binding site. J. Virol. 75, 6874-6883 (2001).
    • (2001) J. Virol. , vol.75 , pp. 6874-6883
    • Heise, T.1    Guidotti, L.G.2    Chisari, F.V.3
  • 105
    • 62949087170 scopus 로고    scopus 로고
    • Analysis of CD8+ T-cell-mediated inhibition of hepatitis C virus replication using a novel immunological model
    • Jo, J. et al. Analysis of CD8+ T-cell-mediated inhibition of hepatitis C virus replication using a novel immunological model. Gastroenterology 136, 1391-1401 (2009).
    • (2009) Gastroenterology , vol.136 , pp. 1391-1401
    • Jo, J.1
  • 106
    • 0033617583 scopus 로고    scopus 로고
    • Viral clearance without destruction of infected cells during acute HBV infection
    • Guidotti, L.G. et al. Viral clearance without destruction of infected cells during acute HBV infection. Science 284, 825-829 (1999).
    • (1999) Science , vol.284 , pp. 825-829
    • Guidotti, L.G.1
  • 107
    • 33750597617 scopus 로고    scopus 로고
    • Virus-induced type i IFN stimulates generation of immunoproteasomes at the site of infection
    • Shin, E.C. et al. Virus-induced type I IFN stimulates generation of immunoproteasomes at the site of infection. J. Clin. Invest. 116, 3006-3014 (2006).
    • (2006) J. Clin. Invest. , vol.116 , pp. 3006-3014
    • Shin, E.C.1
  • 108
    • 0033754682 scopus 로고    scopus 로고
    • Incubation phase of acute hepatitis B in man: Dynamic of cellular immune mechanisms
    • Webster, G.J. et al. Incubation phase of acute hepatitis B in man: dynamic of cellular immune mechanisms. Hepatology 32, 1117-1124 (2000).
    • (2000) Hepatology , vol.32 , pp. 1117-1124
    • Webster, G.J.1
  • 109
    • 0035914925 scopus 로고    scopus 로고
    • Determinants of viral clearance and persistence during acute hepatitis C virus infection
    • Thimme, R. et al. Determinants of viral clearance and persistence during acute hepatitis C virus infection. J. Exp. Med. 194, 1395-1406 (2001).
    • (2001) J. Exp. Med. , vol.194 , pp. 1395-1406
    • Thimme, R.1
  • 110
    • 0346734182 scopus 로고    scopus 로고
    • Conserved hierarchy of helper T cell responses in a chimpanzee during primary and secondary hepatitis C virus infections
    • Shoukry, N.H., Sidney, J., Sette, A. & Walker, C.M. Conserved hierarchy of helper T cell responses in a chimpanzee during primary and secondary hepatitis C virus infections. J. Immunol. 172, 483-492 (2004).
    • (2004) J. Immunol. , vol.172 , pp. 483-492
    • Shoukry, N.H.1    Sidney, J.2    Sette, A.3    Walker, C.M.4
  • 111
    • 67349186530 scopus 로고    scopus 로고
    • Early kinetics of innate and adaptive immune responses during hepatitis B virus infection
    • Fisicaro, P. et al. Early kinetics of innate and adaptive immune responses during hepatitis B virus infection. Gut 58, 974-982 (2009).
    • (2009) Gut , vol.58 , pp. 974-982
    • Fisicaro, P.1
  • 112
    • 70349435373 scopus 로고    scopus 로고
    • Temporal analysis of early immune responses in patients with acute hepatitis B virus infection
    • Dunn, C. et al. Temporal analysis of early immune responses in patients with acute hepatitis B virus infection. Gastroenterology 137, 1289-1300 (2009).
    • (2009) Gastroenterology , vol.137 , pp. 1289-1300
    • Dunn, C.1
  • 113
    • 58949091314 scopus 로고    scopus 로고
    • Natural killer cell function is intact after direct exposure to infectious hepatitis C virions
    • Yoon, J.C., Shiina, M., Ahlenstiel, G. & Rehermann, B. Natural killer cell function is intact after direct exposure to infectious hepatitis C virions. Hepatology 49, 12-21 (2009).
    • (2009) Hepatology , vol.49 , pp. 12-21
    • Yoon, J.C.1    Shiina, M.2    Ahlenstiel, G.3    Rehermann, B.4
  • 114
    • 75549090719 scopus 로고    scopus 로고
    • Hepatitis C virions subvert natural killer cell activation to generate a cytokine environment permissive for infection
    • Crotta, S., Brazzoli, M., Piccioli, D., Valiante, N.M. & Wack, A. Hepatitis C virions subvert natural killer cell activation to generate a cytokine environment permissive for infection. J. Hepatol. 52, 183-190 (2010).
    • (2010) J. Hepatol. , vol.52 , pp. 183-190
    • Crotta, S.1    Brazzoli, M.2    Piccioli, D.3    Valiante, N.M.4    Wack, A.5
  • 115
    • 79251522151 scopus 로고    scopus 로고
    • Hepatitis C virus (HCV) evades NKG2D-dependent NK cell responses through NS5A-mediated imbalance of inflammatory cytokines
    • Sène, D. et al. Hepatitis C virus (HCV) evades NKG2D-dependent NK cell responses through NS5A-mediated imbalance of inflammatory cytokines. PLoS Pathog. 6, e1001184 (2010).
    • (2010) PLoS Pathog. , vol.6
    • Sène, D.1
  • 116
    • 81255180037 scopus 로고    scopus 로고
    • Cell-to-cell contact with hepatitis C virus-infected cells reduces functional capacity of natural killer cells
    • Yoon, J.C., Lim, J.B., Park, J.H. & Lee, J.M. Cell-to-cell contact with hepatitis C virus-infected cells reduces functional capacity of natural killer cells. J. Virol. 85, 12557-12569 (2011).
    • (2011) J. Virol. , vol.85 , pp. 12557-12569
    • Yoon, J.C.1    Lim, J.B.2    Park, J.H.3    Lee, J.M.4
  • 117
    • 0020591841 scopus 로고
    • Natural killer cell depletion enhances virus synthesis and virus-induced hepatitis in vivo
    • Bukowski, J.F., Woda, B.A., Habu, S., Okumura, K. & Welsh, R.M. Natural killer cell depletion enhances virus synthesis and virus-induced hepatitis in vivo. J. Immunol. 131, 1531-1538 (1983).
    • (1983) J. Immunol. , vol.131 , pp. 1531-1538
    • Bukowski, J.F.1    Woda, B.A.2    Habu, S.3    Okumura, K.4    Welsh, R.M.5
  • 118
    • 84870722716 scopus 로고    scopus 로고
    • NK cells controlling virus-specific T cells: Rheostats for acute vs. persistent infections
    • Welsh, R.M. & Waggoner, S.N. NK cells controlling virus-specific T cells: rheostats for acute vs. persistent infections. Virology 435, 37-45 (2013).
    • (2013) Virology , vol.435 , pp. 37-45
    • Welsh, R.M.1    Waggoner, S.N.2
  • 119
    • 84855999478 scopus 로고    scopus 로고
    • Natural killer cells act as rheostats modulating antiviral T cells
    • Waggoner, S.N., Cornberg, M., Selin, L.K. & Welsh, R.M. Natural killer cells act as rheostats modulating antiviral T cells. Nature 481, 394-398 (2012).
    • (2012) Nature , vol.481 , pp. 394-398
    • Waggoner, S.N.1    Cornberg, M.2    Selin, L.K.3    Welsh, R.M.4
  • 120
    • 77953175938 scopus 로고    scopus 로고
    • Absence of mouse 2B4 promotes NK cell-mediated killing of activated CD8+ T cells, leading to prolonged viral persistence and altered pathogenesis
    • Waggoner, S.N., Taniguchi, R.T., Mathew, P.A., Kumar, V. & Welsh, R.M. Absence of mouse 2B4 promotes NK cell-mediated killing of activated CD8+ T cells, leading to prolonged viral persistence and altered pathogenesis. J. Clin. Invest. 120, 1925-1938 (2010).
    • (2010) J. Clin. Invest. , vol.120 , pp. 1925-1938
    • Waggoner, S.N.1    Taniguchi, R.T.2    Mathew, P.A.3    Kumar, V.4    Welsh, R.M.5
  • 121
    • 84872189529 scopus 로고    scopus 로고
    • The depletion of NK cells prevents T cell exhaustion to efficiently control disseminating virus infection
    • Cook, K.D. & Whitmire, J.K. The depletion of NK cells prevents T cell exhaustion to efficiently control disseminating virus infection. J. Immunol. 190, 641-649 (2013).
    • (2013) J. Immunol. , vol.190 , pp. 641-649
    • Cook, K.D.1    Whitmire, J.K.2
  • 122
    • 84863011076 scopus 로고    scopus 로고
    • Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8+ T-cell immunity
    • Lang, P.A. et al. Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8+ T-cell immunity. Proc. Natl. Acad. Sci. USA 109, 1210-1215 (2012).
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , pp. 1210-1215
    • Lang, P.A.1
  • 123
    • 0037378748 scopus 로고    scopus 로고
    • Activated, but not resting, T cells can be recognized and killed by syngeneic NK cells
    • Rabinovich, B.A. et al. Activated, but not resting, T cells can be recognized and killed by syngeneic NK cells. J. Immunol. 170, 3572-3576 (2003).
    • (2003) J. Immunol. , vol.170 , pp. 3572-3576
    • Rabinovich, B.A.1
  • 124
    • 84874543706 scopus 로고    scopus 로고
    • Up-regulation of a death receptor renders antiviral T cells susceptible to NK cell-mediated deletion
    • Peppa, D. et al. Up-regulation of a death receptor renders antiviral T cells susceptible to NK cell-mediated deletion. J. Exp. Med. 210, 99-114 (2013).
    • (2013) J. Exp. Med. , vol.210 , pp. 99-114
    • Peppa, D.1
  • 125
    • 84872800101 scopus 로고    scopus 로고
    • Cytokine-mediated programmed proliferation of virus-specific CD8+ memory T cells
    • Raué, H.P., Beadling, C., Haun, J. & Slifka, M.K. Cytokine-mediated programmed proliferation of virus-specific CD8+ memory T cells. Immunity 38, 131-139 (2013).
    • (2013) Immunity , vol.38 , pp. 131-139
    • Raué, H.P.1    Beadling, C.2    Haun, J.3    Slifka, M.K.4
  • 126
    • 35948954244 scopus 로고    scopus 로고
    • Hepatic stellate cells: Protean, multifunctional, and enigmatic cells of the liver
    • Friedman, S.L. Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Physiol. Rev. 88, 125-172 (2008).
    • (2008) Physiol. Rev. , vol.88 , pp. 125-172
    • Friedman, S.L.1
  • 128
    • 32044443617 scopus 로고    scopus 로고
    • Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in NKG2D-dependent and tumor necrosis factor-related apoptosis-inducing ligand-dependent manners
    • Radaeva, S. et al. Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in NKG2D-dependent and tumor necrosis factor-related apoptosis-inducing ligand-dependent manners. Gastroenterology 130, 435-452 (2006).
    • (2006) Gastroenterology , vol.130 , pp. 435-452
    • Radaeva, S.1
  • 129
    • 33744939234 scopus 로고    scopus 로고
    • Anti-fibrotic activity of NK cells in experimental liver injury through killing of activated HSC
    • Melhem, A. et al. Anti-fibrotic activity of NK cells in experimental liver injury through killing of activated HSC. J. Hepatol. 45, 60-71 (2006).
    • (2006) J. Hepatol. , vol.45 , pp. 60-71
    • Melhem, A.1
  • 130
    • 0037219276 scopus 로고    scopus 로고
    • Activated stellate cells express the TRAIL receptor-2/death receptor-5 and undergo TRAIL-mediated apoptosis
    • Taimr, P. et al. Activated stellate cells express the TRAIL receptor-2/death receptor-5 and undergo TRAIL-mediated apoptosis. Hepatology 37, 87-95 (2003).
    • (2003) Hepatology , vol.37 , pp. 87-95
    • Taimr, P.1
  • 131
    • 84862993192 scopus 로고    scopus 로고
    • NK cells from HCV-infected patients effectively induce apoptosis of activated primary human hepatic stellate cells in a TRAIL-,FasL-and NKG2D-dependent manner
    • Glässner, A. et al. NK cells from HCV-infected patients effectively induce apoptosis of activated primary human hepatic stellate cells in a TRAIL-, FasL-and NKG2D-dependent manner. Lab. Invest. 92, 967-977 (2012).
    • (2012) Lab. Invest. , vol.92 , pp. 967-977
    • Glässner, A.1
  • 132
    • 84867218760 scopus 로고    scopus 로고
    • NKp46high expression defines a NK cell subset that is potentially involved in control of HCV replication and modulation of liver fibrosis
    • Krämer, B. et al. NKp46high expression defines a NK cell subset that is potentially involved in control of HCV replication and modulation of liver fibrosis. Hepatology 56, 1201-1213 (2012).
    • (2012) Hepatology , vol.56 , pp. 1201-1213
    • Krämer, B.1
  • 133
    • 84860596931 scopus 로고    scopus 로고
    • NKp46-mediated killing of human and mouse hepatic stellate cells attenuates liver fibrosis
    • Gur, C. et al. NKp46-mediated killing of human and mouse hepatic stellate cells attenuates liver fibrosis. Gut 61, 885-893 (2012).
    • (2012) Gut , vol.61 , pp. 885-893
    • Gur, C.1
  • 134
    • 0033027064 scopus 로고    scopus 로고
    • La autoantigen specifically recognizes a predicted stem-loop in hepatitis B virus RNA
    • Heise, T., Guidotti, L.G. & Chisari, F.V. La autoantigen specifically recognizes a predicted stem-loop in hepatitis B virus RNA. J. Virol. 73, 5767-5776 (1999).
    • (1999) J. Virol. , vol.73 , pp. 5767-5776
    • Heise, T.1    Guidotti, L.G.2    Chisari, F.V.3
  • 135
    • 30744437415 scopus 로고    scopus 로고
    • Platelets mediate cytotoxic T lymphocyte-induced liver damage
    • Iannacone, M. et al. Platelets mediate cytotoxic T lymphocyte-induced liver damage. Nat. Med. 11, 1167-1169 (2005).
    • (2005) Nat. Med. , vol.11 , pp. 1167-1169
    • Iannacone, M.1
  • 136
    • 0035905411 scopus 로고    scopus 로고
    • Blocking chemokine responsive to -2/interferon (IFN)-? inducible protein and monokine induced by IFN- activity in vivo reduces the pathogenetic but not the antiviral potential of hepatitis B virus-specific cytotoxic T lymphocytes
    • Kakimi, K. et al. Blocking chemokine responsive to 2/interferon (IFN)-inducible protein and monokine induced by IFN-activity in vivo reduces the pathogenetic but not the antiviral potential of hepatitis B virus-specific cytotoxic T lymphocytes. J. Exp. Med. 194, 1755-1766 (2001).
    • (2001) J. Exp. Med. , vol.194 , pp. 1755-1766
    • Kakimi, K.1
  • 137
    • 2142763034 scopus 로고    scopus 로고
    • MMPs are required for recruitment of antigen-nonspecific mononuclear cells into the liver by CTLs
    • Sitia, G. et al. MMPs are required for recruitment of antigen-nonspecific mononuclear cells into the liver by CTLs. J. Clin. Invest. 113, 1158-1167 (2004).
    • (2004) J. Clin. Invest. , vol.113 , pp. 1158-1167
    • Sitia, G.1
  • 138
    • 0037108755 scopus 로고    scopus 로고
    • Depletion of neutrophils blocks the recruitment of antigen-nonspecific cells into the liver without affecting the antiviral activity of hepatitis B virus-specific cytotoxic T lymphocytes
    • Sitia, G. et al. Depletion of neutrophils blocks the recruitment of antigen-nonspecific cells into the liver without affecting the antiviral activity of hepatitis B virus-specific cytotoxic T lymphocytes. Proc. Natl. Acad. Sci. USA 99, 13717-13722 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 13717-13722
    • Sitia, G.1
  • 140
    • 59749096640 scopus 로고    scopus 로고
    • Hepatitis B virus infection
    • Liaw, Y.F. & Chu, C.M. Hepatitis B virus infection. Lancet 373, 582-592 (2009).
    • (2009) Lancet , vol.373 , pp. 582-592
    • Liaw, Y.F.1    Chu, C.M.2
  • 143
    • 0345593806 scopus 로고    scopus 로고
    • Extrahepatic manifestations of HCV infection: Facts and controversies
    • Zignego, A.L. & Brechot, C. Extrahepatic manifestations of HCV infection: facts and controversies. J. Hepatol. 31, 369-376 (1999).
    • (1999) J. Hepatol. , vol.31 , pp. 369-376
    • Zignego, A.L.1    Brechot, C.2
  • 144
    • 0025147370 scopus 로고
    • Is a function of the secreted hepatitis B e antigen to induce immunologic tolerance in utero? Proc
    • Milich, D.R. et al. Is a function of the secreted hepatitis B e antigen to induce immunologic tolerance in utero? Proc. Natl. Acad. Sci. USA 87, 6599-6603 (1990).
    • (1990) Natl. Acad. Sci. USA , vol.87 , pp. 6599-6603
    • Milich, D.R.1
  • 145
    • 13944265920 scopus 로고    scopus 로고
    • Immune tolerance split between hepatitis B virus precore and core proteins
    • Chen, M. et al. Immune tolerance split between hepatitis B virus precore and core proteins. J. Virol. 79, 3016-3027 (2005).
    • (2005) J. Virol. , vol.79 , pp. 3016-3027
    • Chen, M.1
  • 146
    • 79952220107 scopus 로고    scopus 로고
    • IL-21 is pivotal in determining age-dependent effectiveness of immune responses in a mouse model of human hepatitis B
    • Publicover, J. et al. IL-21 is pivotal in determining age-dependent effectiveness of immune responses in a mouse model of human hepatitis B. J. Clin. Invest. 121, 1154-1162 (2011).
    • (2011) J. Clin. Invest. , vol.121 , pp. 1154-1162
    • Publicover, J.1
  • 147
    • 33847067210 scopus 로고    scopus 로고
    • Discordant role of CD4 T-cell response relative to neutralizing antibody and CD8 T-cell responses in acute hepatitis C
    • Kaplan, D.E. et al. Discordant role of CD4 T-cell response relative to neutralizing antibody and CD8 T-cell responses in acute hepatitis C. Gastroenterology 132, 654-666 (2007).
    • (2007) Gastroenterology , vol.132 , pp. 654-666
    • Kaplan, D.E.1
  • 148
    • 16244411318 scopus 로고    scopus 로고
    • Acute phase HBV-specific T cell responses associated with HBV persistence after HBV/HCV coinfection
    • Urbani, S. et al. Acute phase HBV-specific T cell responses associated with HBV persistence after HBV/HCV coinfection. Hepatology 41, 826-831 (2005).
    • (2005) Hepatology , vol.41 , pp. 826-831
    • Urbani, S.1
  • 149
    • 0035196927 scopus 로고    scopus 로고
    • Differential CD4+ and CD8+ T-cell responsiveness in hepatitis C virus infection
    • Chang, K.M. et al. Differential CD4+ and CD8+ T-cell responsiveness in hepatitis C virus infection. Hepatology 33, 267-276 (2001).
    • (2001) Hepatology , vol.33 , pp. 267-276
    • Chang, K.M.1
  • 150
    • 0036892605 scopus 로고    scopus 로고
    • Virus-specific CD8+ lymphocytes share the same effector-memory phenotype but exhibit functional differences in acute hepatitis B and C
    • Urbani, S. et al. Virus-specific CD8+ lymphocytes share the same effector-memory phenotype but exhibit functional differences in acute hepatitis B and C. J. Virol. 76, 12423-12434 (2002).
    • (2002) J. Virol. , vol.76 , pp. 12423-12434
    • Urbani, S.1
  • 151
    • 70349298402 scopus 로고    scopus 로고
    • The size of the viral inoculum contributes to the outcome of hepatitis B virus infection
    • Asabe, S. et al. The size of the viral inoculum contributes to the outcome of hepatitis B virus infection. J. Virol. 83, 9652-9662 (2009).
    • (2009) J. Virol. , vol.83 , pp. 9652-9662
    • Asabe, S.1
  • 152
    • 64049116643 scopus 로고    scopus 로고
    • Induction of a striking systemic cytokine cascade prior to peak viremia in acute human immunodeficiency virus type 1 infection, in contrast to more modest and delayed responses in acute hepatitis B and C virus infections
    • Stacey, A.R. et al. Induction of a striking systemic cytokine cascade prior to peak viremia in acute human immunodeficiency virus type 1 infection, in contrast to more modest and delayed responses in acute hepatitis B and C virus infections. J. Virol. 83, 3719-3733 (2009).
    • (2009) J. Virol. , vol.83 , pp. 3719-3733
    • Stacey, A.R.1
  • 153
  • 154
    • 84863707404 scopus 로고    scopus 로고
    • Hepatitis B virus-induced lipid alterations contribute to natural killer T cell-dependent protective immunity
    • Zeissig, S. et al. Hepatitis B virus-induced lipid alterations contribute to natural killer T cell-dependent protective immunity. Nat. Med. 18, 1060-1068 (2012).
    • (2012) Nat. Med. , vol.18 , pp. 1060-1068
    • Zeissig, S.1
  • 155
    • 70349966196 scopus 로고    scopus 로고
    • Genetic variation in IL28B and spontaneous clearance of hepatitis C virus
    • Thomas, D.L. et al. Genetic variation in IL28B and spontaneous clearance of hepatitis C virus. Nature 461, 798-801 (2009).
    • (2009) Nature , vol.461 , pp. 798-801
    • Thomas, D.L.1
  • 156
    • 80051521537 scopus 로고    scopus 로고
    • Delayed induction, not impaired recruitment, of specific CD8+ T cells causes the late onset of acute hepatitis C
    • 695e1
    • Shin, E.C. et al. Delayed induction, not impaired recruitment, of specific CD8+ T cells causes the late onset of acute hepatitis C. Gastroenterology 141, 686-695, 695.e1 (2011).
    • (2011) Gastroenterology , vol.141 , pp. 686-695
    • Shin, E.C.1
  • 157
    • 0034678435 scopus 로고    scopus 로고
    • The role of virus-specific CD8+ cells in liver damage and viral control during persistent hepatitis B virus infection
    • Maini, M.K. et al. The role of virus-specific CD8+ cells in liver damage and viral control during persistent hepatitis B virus infection. J. Exp. Med. 191, 1269-1280 (2000).
    • (2000) J. Exp. Med. , vol.191 , pp. 1269-1280
    • Maini, M.K.1
  • 158
    • 56349156910 scopus 로고    scopus 로고
    • Lymphocyte recruitment to the liver: Molecular insights into the pathogenesis of liver injury and hepatitis
    • Shetty, S., Lalor, P.F. & Adams, D.H. Lymphocyte recruitment to the liver: molecular insights into the pathogenesis of liver injury and hepatitis. Toxicology 254, 136-146 (2008).
    • (2008) Toxicology , vol.254 , pp. 136-146
    • Shetty, S.1    Lalor, P.F.2    Adams, D.H.3
  • 159
    • 0033485942 scopus 로고    scopus 로고
    • Chemokine and chemokine receptor interactions provide a mechanism for selective T cell recruitment to specific liver compartments within hepatitis C-infected liver
    • Shields, P.L. et al. Chemokine and chemokine receptor interactions provide a mechanism for selective T cell recruitment to specific liver compartments within hepatitis C-infected liver. J. Immunol. 163, 6236-6243 (1999).
    • (1999) J. Immunol. , vol.163 , pp. 6236-6243
    • Shields, P.L.1
  • 160
    • 77249098281 scopus 로고    scopus 로고
    • A longitudinal analysis of innate and adaptive immune profile during hepatic flares in chronic hepatitis B
    • Tan, A.T. et al. A longitudinal analysis of innate and adaptive immune profile during hepatic flares in chronic hepatitis B. J. Hepatol. 52, 330-339 (2010).
    • (2010) J. Hepatol. , vol.52 , pp. 330-339
    • Tan, A.T.1
  • 161
    • 0030959049 scopus 로고    scopus 로고
    • Interleukin-12 induction of TH1 cytokines is important for viral clearance in chronic hepatitis B
    • Rossol, S. et al. Interleukin-12 induction of TH1 cytokines is important for viral clearance in chronic hepatitis B. J. Clin. Invest. 99, 3025-3033 (1997).
    • (1997) J. Clin. Invest. , vol.99 , pp. 3025-3033
    • Rossol, S.1
  • 162
    • 2442682870 scopus 로고    scopus 로고
    • Longitudinal analysis of CD8+ T cells specific for structural and nonstructural hepatitis B virus proteins in patients with chronic hepatitis B: Implications for immunotherapy
    • Webster, G.J. et al. Longitudinal analysis of CD8+ T cells specific for structural and nonstructural hepatitis B virus proteins in patients with chronic hepatitis B: implications for immunotherapy. J. Virol. 78, 5707-5719 (2004).
    • (2004) J. Virol. , vol.78 , pp. 5707-5719
    • Webster, G.J.1
  • 163
    • 72849128563 scopus 로고    scopus 로고
    • Peripheral CXCR3-associated chemokines as biomarkers of fibrosis in chronic hepatitis C virus infection
    • Zeremski, M. et al. Peripheral CXCR3-associated chemokines as biomarkers of fibrosis in chronic hepatitis C virus infection. J. Infect. Dis. 200, 1774-1780 (2009).
    • (2009) J. Infect. Dis. , vol.200 , pp. 1774-1780
    • Zeremski, M.1
  • 164
    • 56149085947 scopus 로고    scopus 로고
    • Intrahepatic levels of CXCR3-associated chemokines correlate with liver inflammation and fibrosis in chronic hepatitis C
    • Zeremski, M. et al. Intrahepatic levels of CXCR3-associated chemokines correlate with liver inflammation and fibrosis in chronic hepatitis C. Hepatology 48, 1440-1450 (2008).
    • (2008) Hepatology , vol.48 , pp. 1440-1450
    • Zeremski, M.1
  • 165
    • 78650962504 scopus 로고    scopus 로고
    • Evidence for an antagonist form of the chemokine CXCL10 in patients chronically infected with HCV
    • Casrouge, A. et al. Evidence for an antagonist form of the chemokine CXCL10 in patients chronically infected with HCV. J. Clin. Invest. 121, 308-317 (2011).
    • (2011) J. Clin. Invest. , vol.121 , pp. 308-317
    • Casrouge, A.1


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