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Volumn 31, Issue , 2015, Pages 317-345

Studying Lineage Decision-Making in Vitro: Emerging Concepts and Novel Tools

Author keywords

Embryonic stem cells; Gene regulatory networks; In vitro differentiation; Lineage decision making; Single cell heterogeneity

Indexed keywords

DNA; TRANSCRIPTION FACTOR;

EID: 84947258947     PISSN: 10810706     EISSN: 15308995     Source Type: Book Series    
DOI: 10.1146/annurev-cellbio-100814-125300     Document Type: Article
Times cited : (35)

References (206)
  • 1
    • 84904012047 scopus 로고    scopus 로고
    • StochasticNANOG fluctuations allow mouse embryonic stem cells to explore pluripotency
    • Abranches E,Guedes AMV,Moravec M, Maamar H, Svoboda P, et al. 2014. StochasticNANOG fluctuations allow mouse embryonic stem cells to explore pluripotency. Development 141(14):2770-79
    • (2014) Development , vol.141 , Issue.14 , pp. 2770-2779
    • Abranches, E.1    Guedes, A.M.V.2    Moravec, M.3    Maamar, H.4    Svoboda, P.5
  • 2
    • 34249079154 scopus 로고    scopus 로고
    • Network motifs: Theory and experimental approaches
    • Alon U. 2007. Network motifs: theory and experimental approaches. Nat. Rev. Genet. 8(6):450-61
    • (2007) Nat. Rev. Genet , vol.8 , Issue.6 , pp. 450-461
    • Alon, U.1
  • 3
    • 84893115719 scopus 로고    scopus 로고
    • Global discovery of erythroid long noncoding RNAs reveals novel regulators of red cell maturation
    • Alvarez-Dominguez JR, Hu W, Yuan B, Shi J, Park SS, et al. 2014. Global discovery of erythroid long noncoding RNAs reveals novel regulators of red cell maturation. Blood 123(4):570-81
    • (2014) Blood , vol.123 , Issue.4 , pp. 570-581
    • Alvarez-Dominguez, J.R.1    Hu, W.2    Yuan, B.3    Shi, J.4    Park, S.S.5
  • 4
    • 84883022375 scopus 로고    scopus 로고
    • High throughput screening to investigate the interaction of stem cells with their extracellular microenvironment
    • Ankam S, Teo BK, Kukumberg M, Yim EK. 2013. High throughput screening to investigate the interaction of stem cells with their extracellular microenvironment. Organogenesis 9(3):128-42
    • (2013) Organogenesis , vol.9 , Issue.3 , pp. 128-142
    • Ankam, S.1    Teo, B.K.2    Kukumberg, M.3    Yim, E.K.4
  • 5
    • 79952638264 scopus 로고    scopus 로고
    • Cellular decision making and biological noise: From microbes to mammals
    • Balazsi G, van Oudenaarden A, Collins JJ. 2011. Cellular decision making and biological noise: from microbes to mammals. Cell 144(6):910-25
    • (2011) Cell , vol.144 , Issue.6 , pp. 910-925
    • Balazsi, G.1    Van Oudenaarden, A.2    Collins, J.J.3
  • 6
    • 0038483826 scopus 로고    scopus 로고
    • Emergence of scaling in random networks
    • Barabasi A-L, Albert R. 1999. Emergence of scaling in random networks. Science 286(5439):509-12
    • (1999) Science , vol.286 , Issue.5439 , pp. 509-512
    • Barabasi, A.-L.1    Albert, R.2
  • 7
    • 0742305866 scopus 로고    scopus 로고
    • Network biology: Understanding the cell's functional organization
    • Barabasi A-L, Oltvai ZN. 2004. Network biology: understanding the cell's functional organization. Nat. Rev. Genet. 5(2):101-13
    • (2004) Nat. Rev. Genet , vol.5 , Issue.2 , pp. 101-113
    • Barabasi, A.-L.1    Oltvai, Z.N.2
  • 8
    • 0024517749 scopus 로고
    • An assessment of the developmental potential of embryonic stem cells in the midgestation mouse embryo
    • Beddington RS, Robertson EJ. 1989. An assessment of the developmental potential of embryonic stem cells in the midgestation mouse embryo. Development 105(4):733-37
    • (1989) Development , vol.105 , Issue.4 , pp. 733-737
    • Beddington, R.S.1    Robertson, E.J.2
  • 9
    • 84899574465 scopus 로고    scopus 로고
    • Single-cell trajectory detection uncovers progression and regulatory coordination in human B cell development
    • Bendall SC, Davis KL, Amir E-AD, Tadmor MD, Simonds EF, et al. 2014. Single-cell trajectory detection uncovers progression and regulatory coordination in human B cell development. Cell 157(3):714-25
    • (2014) Cell , vol.157 , Issue.3 , pp. 714-725
    • Bendall, S.C.1    Davis, K.L.2    Amir, E.-A.D.3    Tadmor, M.D.4    Simonds, E.F.5
  • 10
    • 79955750055 scopus 로고    scopus 로고
    • Single-cellmass cytometry of differential immune and drug responses across a human hematopoietic continuum
    • Bendall SC, Simonds EF,Qiu P, AmirE-AD, Krutzik PO, et al. 2011. Single-cellmass cytometry of differential immune and drug responses across a human hematopoietic continuum. Science 332(6030):687-96
    • (2011) Science , vol.332 , Issue.6030 , pp. 687-696
    • Bendall, S.C.1    Simonds, E.F.2    Qiu, P.3    AmirE-AD4    Krutzik, P.O.5
  • 11
    • 33646070846 scopus 로고    scopus 로고
    • A bivalent chromatin structure marks key developmental genes in embryonic stem cells
    • Bernstein BE, Mikkelsen TS, Xie X, KamalM, Huebert DJ, et al. 2006. A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 125(2):315-26
    • (2006) Cell , vol.125 , Issue.2 , pp. 315-326
    • Bernstein, B.E.1    Mikkelsen, T.S.2    Xie, X.3    Kamal, M.4    Huebert, D.J.5
  • 12
    • 84876261517 scopus 로고    scopus 로고
    • Exit from pluripotency is gated by intracellular redistribution of the bHLH transcription factor Tfe3
    • Betschinger J, Nichols J, Dietmann S, Corrin PD, Paddison PJ, Smith A. 2013. Exit from pluripotency is gated by intracellular redistribution of the bHLH transcription factor Tfe3. Cell 153(2):335-47
    • (2013) Cell , vol.153 , Issue.2 , pp. 335-347
    • Betschinger, J.1    Nichols, J.2    Dietmann, S.3    Corrin, P.D.4    Paddison, P.J.5    Smith, A.6
  • 13
    • 84927698129 scopus 로고    scopus 로고
    • Epigenetics reloaded: The single-cell revolution
    • Bheda P, Schneider R. 2014. Epigenetics reloaded: the single-cell revolution. Trends Cell Biol. 24(11):712-23
    • (2014) Trends Cell Biol , vol.24 , Issue.11 , pp. 712-723
    • Bheda, P.1    Schneider, R.2
  • 14
    • 84893226649 scopus 로고    scopus 로고
    • Genes related to differentiation are correlated with the gene regulatory network structure
    • Bodaker M, Meshorer E, Mitrani E, Louzoun Y. 2014. Genes related to differentiation are correlated with the gene regulatory network structure. Bioinformatics 30(3):406-13
    • (2014) Bioinformatics , vol.30 , Issue.3 , pp. 406-413
    • Bodaker, M.1    Meshorer, E.2    Mitrani, E.3    Louzoun, Y.4
  • 15
    • 84901758151 scopus 로고    scopus 로고
    • The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification
    • Boroviak T, Loos R, Bertone P, Smith A, Nichols J. 2014. The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification. Nat. Cell Biol. 16(6):516-28
    • (2014) Nat. Cell Biol , vol.16 , Issue.6 , pp. 516-528
    • Boroviak, T.1    Loos, R.2    Bertone, P.3    Smith, A.4    Nichols, J.5
  • 16
    • 25144525014 scopus 로고    scopus 로고
    • Core transcriptional regulatory circuitry in human embryonic stem cells
    • Boyer LA, Lee TI, Cole MF, Johnstone SE, Levine SS, et al. 2005. Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 122(6):947-56
    • (2005) Cell , vol.122 , Issue.6 , pp. 947-956
    • Boyer, L.A.1    Lee, T.I.2    Cole, M.F.3    Johnstone, S.E.4    Levine, S.S.5
  • 17
    • 33646882068 scopus 로고    scopus 로고
    • Polycomb complexes repress developmental regulators in murine embryonic stem cells
    • Boyer LA, Plath K, Zeitlinger J, Brambrink T, Medeiros LA, et al. 2006. Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature 441(7091):349-53
    • (2006) Nature , vol.441 , Issue.7091 , pp. 349-353
    • Boyer, L.A.1    Plath, K.2    Zeitlinger, J.3    Brambrink, T.4    Medeiros, L.A.5
  • 18
    • 34447527158 scopus 로고    scopus 로고
    • Derivation of pluripotent epiblast stem cells from mammalian embryos
    • Brons IGM, Smithers LE, TrotterMWB, Rugg-Gunn P, Sun B, et al. 2007. Derivation of pluripotent epiblast stem cells from mammalian embryos. Nature 448(7150):191-95
    • (2007) Nature , vol.448 , Issue.7150 , pp. 191-195
    • Brons, I.G.M.1    Smithers, L.E.2    Trotter, M.W.B.3    Rugg-Gunn, P.4    Sun, B.5
  • 19
    • 84902184462 scopus 로고    scopus 로고
    • Reorganization of enhancer patterns in transition from naive to primed pluripotency
    • Buecker C, Srinivasan R, Wu Z, Calo E, Acampora D, et al. 2014. Reorganization of enhancer patterns in transition from naive to primed pluripotency. Cell Stem Cell 14(6):838-53
    • (2014) Cell Stem Cell , vol.14 , Issue.6 , pp. 838-853
    • Buecker, C.1    Srinivasan, R.2    Wu, Z.3    Calo, E.4    Acampora, D.5
  • 20
    • 84923292191 scopus 로고    scopus 로고
    • Computational analysis of cellto-cell heterogeneity in single-cell RNA-sequencing data reveals hidden subpopulations of cells
    • Buettner F, Natarajan KN, Casale FP, Proserpio V, Scialdone A, et al. 2015. Computational analysis of cellto-cell heterogeneity in single-cell RNA-sequencing data reveals hidden subpopulations of cells. Nat. Biotechnol. 33(2):155-60
    • (2015) Nat. Biotechnol , vol.33 , Issue.2 , pp. 155-160
    • Buettner, F.1    Natarajan, K.N.2    Casale, F.P.3    Proserpio, V.4    Scialdone, A.5
  • 22
    • 84876836223 scopus 로고    scopus 로고
    • Modification of enhancer chromatin: What, how, and why
    • Calo E, Wysocka J. 2013. Modification of enhancer chromatin: what, how, and why? Mol. Cell 49(5):825-37
    • (2013) Mol. Cell , vol.49 , Issue.5 , pp. 825-837
    • Calo, E.1    Wysocka, J.2
  • 23
    • 77952915049 scopus 로고    scopus 로고
    • Functional heterogeneity of embryonic stem cells revealed through translational amplification of an early endodermal transcript
    • Canham MA, Sharov AA, Ko MSH, Brickman JM. 2010. Functional heterogeneity of embryonic stem cells revealed through translational amplification of an early endodermal transcript. PLOS Biol. 8(5):e1000379
    • (2010) PLOS Biol , vol.8 , Issue.5 , pp. e1000379
    • Canham, M.A.1    Sharov, A.A.2    Ko, M.S.H.3    Brickman, J.M.4
  • 24
    • 26644460415 scopus 로고    scopus 로고
    • Perception of differentiation cues by GATA factors in primitive endoderm lineage determination of mouse embryonic stem cells
    • Capo-Chichi CD, Rula ME, Smedberg JL, Vanderveer L, Parmacek MS, et al. 2005. Perception of differentiation cues by GATA factors in primitive endoderm lineage determination of mouse embryonic stem cells. Dev. Biol. 286(2):574-86
    • (2005) Dev. Biol , vol.286 , Issue.2 , pp. 574-586
    • Capo-Chichi, C.D.1    Rula, M.E.2    Smedberg, J.L.3    Vanderveer, L.4    Parmacek, M.S.5
  • 25
    • 84875200698 scopus 로고    scopus 로고
    • Functional implications of genome topology
    • Cavalli G, Misteli T. 2013. Functional implications of genome topology. Nat. Struct. Mol. Biol. 20(3):290-99
    • (2013) Nat. Struct. Mol. Biol , vol.20 , Issue.3 , pp. 290-299
    • Cavalli, G.1    Misteli, T.2
  • 26
    • 37549002155 scopus 로고    scopus 로고
    • Nanog safeguards pluripotency andmediates germline development
    • Chambers I, Silva J, Colby D, Nichols J,Nijmeijer B, et al. 2007. Nanog safeguards pluripotency andmediates germline development. Nature 450(7173):1230-34
    • (2007) Nature , vol.450 , Issue.7173 , pp. 1230-1234
    • Chambers, I.1    Silva, J.2    Colby, D.3    Nichols, J.4    Nijmeijer, B.5
  • 27
    • 84890079514 scopus 로고    scopus 로고
    • Induction of a human pluripotent state with distinct regulatory circuitry that resembles preimplantation epiblast
    • Chan Y-S, Goke J, Ng J-H, Lu X, Gonzales KAU, et al. 2013. Induction of a human pluripotent state with distinct regulatory circuitry that resembles preimplantation epiblast. Cell Stem Cell 13(6):663-75
    • (2013) Cell Stem Cell , vol.13 , Issue.6 , pp. 663-675
    • Chan, Y.-S.1    Goke, J.2    Ng, J.-H.3    Lu, X.4    Gonzales, K.A.U.5
  • 28
    • 44349162752 scopus 로고    scopus 로고
    • Transcriptome-wide noise controls lineage choice in mammalian progenitor cells
    • ChangHH, HembergM, BarahonaM, IngberDE, Huang S. 2008. Transcriptome-wide noise controls lineage choice in mammalian progenitor cells. Nature 453(7194):544-47
    • (2008) Nature , vol.453 , Issue.7194 , pp. 544-547
    • Chang, H.H.1    Hemberg, M.2    Barahona, M.3    Ingber, D.E.4    Huang, S.5
  • 29
    • 84929143160 scopus 로고    scopus 로고
    • Single-cell transcriptional analysis to uncover regulatory circuits driving cell fate decisions in earlymouse development
    • Chen H, Guo J,Mishra SK, Robson P, NiranjanM, Zheng J. 2014. Single-cell transcriptional analysis to uncover regulatory circuits driving cell fate decisions in earlymouse development. Bioinformatics 31(7):1060-66
    • (2014) Bioinformatics , vol.31 , Issue.7 , pp. 1060-1066
    • Chen, H.1    Guo, J.2    Mishra, S.K.3    Robson, P.4    Niranjan, M.5    Zheng, J.6
  • 30
    • 84856264773 scopus 로고    scopus 로고
    • A two-dimensional ERK-AKT signaling code for an NGF-triggered cell-fate decision
    • Chen J-Y, Lin J-R, Cimprich KA, Meyer T. 2012. A two-dimensional ERK-AKT signaling code for an NGF-triggered cell-fate decision. Mol. Cell 45(2):196-209
    • (2012) Mol. Cell , vol.45 , Issue.2 , pp. 196-209
    • Chen, J.-Y.1    Lin, J.-R.2    Cimprich, K.A.3    Meyer, T.4
  • 31
    • 84928395184 scopus 로고    scopus 로고
    • Spatially resolved, highly multiplexed RNA profiling in single cells
    • Chen KH, Boettiger AN, Moffitt JR, Wang S, Zhuang X. 2015. Spatially resolved, highly multiplexed RNA profiling in single cells. Science 348(6233):aaa6090
    • (2015) Science , vol.348 , Issue.6233 , pp. aaa6090
    • Chen, K.H.1    Boettiger, A.N.2    Moffitt, J.R.3    Wang, S.4    Zhuang, X.5
  • 32
    • 84892814234 scopus 로고    scopus 로고
    • Chromatin modifiers and remodellers: Regulators of cellular differentiation
    • Chen T, Dent SYR. 2013. Chromatin modifiers and remodellers: regulators of cellular differentiation. Nat. Rev. Genet. 15(2):93-106
    • (2013) Nat. Rev. Genet , vol.15 , Issue.2 , pp. 93-106
    • Chen, T.1    Dent, S.Y.R.2
  • 33
    • 44649117905 scopus 로고    scopus 로고
    • Integration of external signaling pathways with the core transcriptional network in embryonic stem cells
    • Chen X, Xu H, Yuan P, Fang F, Huss M, et al. 2008. Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell 133(6):1106-17
    • (2008) Cell , vol.133 , Issue.6 , pp. 1106-1117
    • Chen, X.1    Xu, H.2    Yuan, P.3    Fang, F.4    Huss, M.5
  • 34
    • 79952900560 scopus 로고    scopus 로고
    • Turning straw into gold: Directing cell fate for regenerative medicine
    • Cohen DE, Melton D. 2011. Turning straw into gold: directing cell fate for regenerative medicine. Nat. Rev. Genet. 12(4):243-52
    • (2011) Nat. Rev. Genet , vol.12 , Issue.4 , pp. 243-252
    • Cohen, D.E.1    Melton, D.2
  • 35
    • 84869878732 scopus 로고    scopus 로고
    • A short G1 phase is an intrinsic determinant of naïve embryonic stem cell pluripotency
    • Coronado D, Godet M, Bourillot P-Y, Tapponnier Y, Bernat A, et al. 2013. A short G1 phase is an intrinsic determinant of naïve embryonic stem cell pluripotency. Stem Cell Res. 10(1):118-31
    • (2013) Stem Cell Res , vol.10 , Issue.1 , pp. 118-131
    • Coronado, D.1    Godet, M.2    Bourillot, P.-Y.3    Tapponnier, Y.4    Bernat, A.5
  • 37
    • 84890776751 scopus 로고    scopus 로고
    • Roles for Tbx3 in regulation of two-cell state and telomere elongation in mouse ES cells
    • Dan J, Li M, Yang J, Li J, Okuka M, et al. 2013. Roles for Tbx3 in regulation of two-cell state and telomere elongation in mouse ES cells. Sci. Rep. 3:3492
    • (2013) Sci. Rep , vol.3 , pp. 3492
    • Dan, J.1    Li, M.2    Yang, J.3    Li, J.4    Okuka, M.5
  • 38
    • 84892179132 scopus 로고    scopus 로고
    • Single-cell RNA-seq reveals dynamic, random monoallelic gene expression in mammalian cells
    • Deng Q, RamskoldD,Reinius B, Sandberg R. 2014. Single-cell RNA-seq reveals dynamic, random monoallelic gene expression in mammalian cells. Science 343(6167):193-96
    • (2014) Science , vol.343 , Issue.6167 , pp. 193-196
    • Deng, Q.1    Ramskold, D.2    Reinius, B.3    Sandberg, R.4
  • 39
    • 84901837819 scopus 로고    scopus 로고
    • Defining an essential transcription factor program for naive pluripotency
    • Dunn SJ, Martello G, Yordanov B, Emmott S, Smith AG. 2014. Defining an essential transcription factor program for naive pluripotency. Science 344(6188):1156-60
    • (2014) Science , vol.344 , Issue.6188 , pp. 1156-1160
    • Dunn, S.J.1    Martello, G.2    Yordanov, B.3    Emmott, S.4    Smith, A.G.5
  • 40
    • 84860324470 scopus 로고    scopus 로고
    • Roles for microRNAs in conferring robustness to biological processes
    • Ebert MS, Sharp PA. 2012. Roles for microRNAs in conferring robustness to biological processes. Cell 149(3):515-24
    • (2012) Cell , vol.149 , Issue.3 , pp. 515-524
    • Ebert, M.S.1    Sharp, P.A.2
  • 41
    • 84901424141 scopus 로고    scopus 로고
    • Random monoallelic expression: Regulating gene expression one allele at a time
    • Eckersley-Maslin MA, Spector DL. 2014. Random monoallelic expression: regulating gene expression one allele at a time. Trends Genet. 30(6):237-44
    • (2014) Trends Genet , vol.30 , Issue.6 , pp. 237-244
    • Eckersley-Maslin, M.A.1    Spector, D.L.2
  • 42
    • 79953749322 scopus 로고    scopus 로고
    • Self-organizing optic-cupmorphogenesis in three-dimensional culture
    • Eiraku M, Takata N, Ishibashi H, Kawada M, Sakakura E, et al. 2011. Self-organizing optic-cupmorphogenesis in three-dimensional culture. Nature 472(7341):51-56
    • (2011) Nature , vol.472 , Issue.7341 , pp. 51-56
    • Eiraku, M.1    Takata, N.2    Ishibashi, H.3    Kawada, M.4    Sakakura, E.5
  • 43
    • 0037119587 scopus 로고    scopus 로고
    • Stochastic gene expression in a single cell
    • Elowitz MB. 2002. Stochastic gene expression in a single cell. Science 297(5584):1183-86
    • (2002) Science , vol.297 , Issue.5584 , pp. 1183-1186
    • Elowitz, M.B.1
  • 44
    • 77958141582 scopus 로고    scopus 로고
    • Retinoic acid synthesis promotes development of neural progenitors from mouse embryonic stem cells by suppressing endogenous, Wnt-dependent nodal signaling
    • Engberg N, Kahn M, Petersen DR,HanssonM, Serup P. 2010. Retinoic acid synthesis promotes development of neural progenitors from mouse embryonic stem cells by suppressing endogenous, Wnt-dependent nodal signaling. Stem Cells 28(9):1498-509
    • (2010) Stem Cells , vol.28 , Issue.9 , pp. 1498-1509
    • Engberg, N.1    Kahn, M.2    Petersen, D.R.3    Hansson, M.4    Serup, P.5
  • 45
    • 33747152561 scopus 로고    scopus 로고
    • Matrix elasticity directs stem cell lineage specification
    • Engler AJ, Sen S, Sweeney HL, Discher DE. 2006. Matrix elasticity directs stem cell lineage specification. Cell 126(4):677-89
    • (2006) Cell , vol.126 , Issue.4 , pp. 677-689
    • Engler, A.J.1    Sen, S.2    Sweeney, H.L.3    Discher, D.E.4
  • 46
    • 65349097905 scopus 로고    scopus 로고
    • Stem cell states, fates, and the rules of attraction
    • Enver T, Pera M, Peterson C, Andrews PW. 2009. Stem cell states, fates, and the rules of attraction. Cell Stem Cell 4(5):387-97
    • (2009) Cell Stem Cell , vol.4 , Issue.5 , pp. 387-397
    • Enver, T.1    Pera, M.2    Peterson, C.3    Andrews, P.W.4
  • 47
    • 84922629832 scopus 로고    scopus 로고
    • Quantitative single-cell approaches to stem cell research
    • Etzrodt M, Endele M, Schroeder T. 2014. Quantitative single-cell approaches to stem cell research. Stem Cell 15(5):546-58
    • (2014) Stem Cell , vol.15 , Issue.5 , pp. 546-558
    • Etzrodt, M.1    Endele, M.2    Schroeder, T.3
  • 48
    • 84884287890 scopus 로고    scopus 로고
    • Single-cell analysis reveals that expression of Nanog is biallelic and equally variable as that of other pluripotency factors in mouse ESCs
    • Faddah DA, Wang H, Cheng AW, Katz Y, Buganim Y, Jaenisch R. 2013. Single-cell analysis reveals that expression of Nanog is biallelic and equally variable as that of other pluripotency factors in mouse ESCs. Cell Stem Cell 13(1):23-29
    • (2013) Cell Stem Cell , vol.13 , Issue.1 , pp. 23-29
    • Faddah, D.A.1    Wang, H.2    Cheng, A.W.3    Katz, Y.4    Buganim, Y.5    Jaenisch, R.6
  • 49
    • 84880953116 scopus 로고    scopus 로고
    • Stochastic cytokine expression induces mixed T helper cell states
    • Fang M, Xie H, Dougan SK, Ploegh H, van Oudenaarden A. 2013. Stochastic cytokine expression induces mixed T helper cell states. PLOS Biol. 11(7):e1001618
    • (2013) PLOS Biol , vol.11 , Issue.7 , pp. e1001618
    • Fang, M.1    Xie, H.2    Dougan, S.K.3    Ploegh, H.4    Van Oudenaarden, A.5
  • 50
    • 84890559595 scopus 로고    scopus 로고
    • Long non-coding RNAs: New players in cell differentiation and development
    • Fatica A, Bozzoni I. 2014. Long non-coding RNAs: new players in cell differentiation and development. Nat. Rev. Genet. 15(1):7-21
    • (2014) Nat. Rev. Genet , vol.15 , Issue.1 , pp. 7-21
    • Fatica, A.1    Bozzoni, I.2
  • 51
    • 33645132331 scopus 로고    scopus 로고
    • G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis
    • Feldman N, Gerson A, Fang J, Li E, Zhang Y, et al. 2006. G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis. Nat. Cell Biol. 8(2):188-94
    • (2006) Nat. Cell Biol , vol.8 , Issue.2 , pp. 188-194
    • Feldman, N.1    Gerson, A.2    Fang, J.3    Li, E.4    Zhang, Y.5
  • 52
    • 84884164554 scopus 로고    scopus 로고
    • FGF signaling inhibition in ESCs drives rapid genome-wide demethylation to the epigenetic ground state of pluripotency
    • Ficz G, Hore TA, Santos F, Lee HJ, Dean W, et al. 2013. FGF signaling inhibition in ESCs drives rapid genome-wide demethylation to the epigenetic ground state of pluripotency. Cell Stem Cell 13(3):351-59
    • (2013) Cell Stem Cell , vol.13 , Issue.3 , pp. 351-359
    • Ficz, G.1    Hore, T.A.2    Santos, F.3    Lee, H.J.4    Dean, W.5
  • 53
    • 84890128972 scopus 로고    scopus 로고
    • Biallelic expression of Nanog protein in mouse embryonic stem cells
    • Filipczyk A, Gkatzis K, Fu J, Hoppe PS, LickertH, et al. 2013. Biallelic expression of Nanog protein in mouse embryonic stem cells. Cell Stem Cell 13(1):12-13
    • (2013) Cell Stem Cell , vol.13 , Issue.1 , pp. 12-13
    • Filipczyk, A.1    Gkatzis, K.2    Fu, J.3    Hoppe, P.S.4    Lickert, H.5
  • 54
    • 39449127641 scopus 로고    scopus 로고
    • Combinatorial signaling microenvironments for studying stem cell fate
    • Flaim CJ, Teng D, Chien S, Bhatia SN. 2008. Combinatorial signaling microenvironments for studying stem cell fate. Stem Cells Dev. 17(1):29-39
    • (2008) Stem Cells Dev , vol.17 , Issue.1 , pp. 29-39
    • Flaim, C.J.1    Teng, D.2    Chien, S.3    Bhatia, S.N.4
  • 55
    • 84902144564 scopus 로고    scopus 로고
    • Human intestinal tissue with adult stem cell properties derived from pluripotent stem cells
    • Forster R, Chiba K, Schaeffer L, Regalado SG, Lai CS, et al. 2014. Human intestinal tissue with adult stem cell properties derived from pluripotent stem cells. Stem Cell Rep. 2(6):838-52
    • (2014) Stem Cell Rep , vol.2 , Issue.6 , pp. 838-852
    • Forster, R.1    Chiba, K.2    Schaeffer, L.3    Regalado, S.G.4    Lai, C.S.5
  • 56
    • 84867303343 scopus 로고    scopus 로고
    • A dynamical-systems view of stem cell biology
    • Furusawa C, Kaneko K. 2012. A dynamical-systems view of stem cell biology. Science 338(6104):215-17
    • (2012) Science , vol.338 , Issue.6104 , pp. 215-217
    • Furusawa, C.1    Kaneko, K.2
  • 57
    • 84890439421 scopus 로고    scopus 로고
    • Derivation of novel human ground state naive pluripotent stem cells
    • Gafni O,Weinberger L,Mansour AA, Manor YS, Chomsky E, et al. 2013. Derivation of novel human ground state naive pluripotent stem cells. Nature 504(7479):282-86
    • (2013) Nature , vol.504 , Issue.7479 , pp. 282-286
    • Gafni, O.1    Weinberger, L.2    Mansour, A.A.3    Manor, Y.S.4    Chomsky, E.5
  • 58
    • 84878292277 scopus 로고    scopus 로고
    • Transcriptional and epigenetic dynamics during specification of human embryonic stem cells
    • Gifford CA, Ziller MJ, Gu H, Trapnell C, Donaghey J, et al. 2013. Transcriptional and epigenetic dynamics during specification of human embryonic stem cells. Cell 153(5):1149-63
    • (2013) Cell , vol.153 , Issue.5 , pp. 1149-1163
    • Gifford, C.A.1    Ziller, M.J.2    Gu, H.3    Trapnell, C.4    Donaghey, J.5
  • 59
    • 28944434119 scopus 로고    scopus 로고
    • Real-time kinetics of gene activity in individual bacteria
    • Golding I, Paulsson J, Zawilski SM, Cox EC. 2005. Real-time kinetics of gene activity in individual bacteria. Cell 123(6):1025-36
    • (2005) Cell , vol.123 , Issue.6 , pp. 1025-1036
    • Golding, I.1    Paulsson, J.2    Zawilski, S.M.3    Cox, E.C.4
  • 60
    • 84902212007 scopus 로고    scopus 로고
    • The 3Dgenome in transcriptional regulation and pluripotency
    • Gorkin DU, LeungD, Ren B. 2014. The 3Dgenome in transcriptional regulation and pluripotency. Cell Stem Cell 14(6):762-75
    • (2014) Cell Stem Cell , vol.14 , Issue.6 , pp. 762-775
    • Gorkin, D.U.1    Leung, D.2    Ren, B.3
  • 61
    • 84901831004 scopus 로고    scopus 로고
    • Validation of noise models for single-cell transcriptomics
    • Grun D, Kester L, van Oudenaarden A. 2014. Validation of noise models for single-cell transcriptomics. Nat. Methods 11(6):637-40
    • (2014) Nat. Methods , vol.11 , Issue.6 , pp. 637-640
    • Grun, D.1    Kester, L.2    Van Oudenaarden, A.3
  • 62
    • 84941201582 scopus 로고    scopus 로고
    • Single-cell messenger RNA sequencing reveals rare intestinal cell types
    • Grun D, Lyubimova A, Kester L, Wiebrands K, Basak O, et al. 2015. Single-cell messenger RNA sequencing reveals rare intestinal cell types. Nature 525:251-55
    • (2015) Nature , vol.525 , pp. 251-255
    • Grun, D.1    Lyubimova, A.2    Kester, L.3    Wiebrands, K.4    Basak, O.5
  • 63
    • 84867553284 scopus 로고    scopus 로고
    • Expression of endogenous retroviruses is negatively regulated by the pluripotency marker Rex1/Zfp42
    • Guallar D, Perez-Palacios R, ClimentM,Martinez-Abadia I, Larraga A, et al. 2012. Expression of endogenous retroviruses is negatively regulated by the pluripotency marker Rex1/Zfp42. Nucleic Acids Res. 40(18):8993-9007
    • (2012) Nucleic Acids Res , vol.40 , Issue.18 , pp. 8993-9007
    • Guallar, D.1    Perez-Palacios, R.2    Climent, M.3    Martinez-Abadia, I.4    Larraga, A.5
  • 64
    • 77955644289 scopus 로고    scopus 로고
    • Mammalian microRNAs predominantly act to decrease target mRNA levels
    • Guo H, Ingolia NT,Weissman JS, Bartel DP. 2010. Mammalian microRNAs predominantly act to decrease target mRNA levels. Nature 466(7308):835-40
    • (2010) Nature , vol.466 , Issue.7308 , pp. 835-840
    • Guo, H.1    Ingolia, N.T.2    Weissman, J.S.3    Bartel, D.P.4
  • 65
    • 80052869283 scopus 로고    scopus 로고
    • LincRNAs act in the circuitry controlling pluripotency and differentiation
    • Guttman M, Donaghey J, Carey BW, Garber M, Grenier JK, et al. 2011. lincRNAs act in the circuitry controlling pluripotency and differentiation. Nature 447(7364):295-300
    • (2011) Nature , vol.447 , Issue.7364 , pp. 295-300
    • Guttman, M.1    Donaghey, J.2    Carey, B.W.3    Garber, M.4    Grenier, J.K.5
  • 66
    • 84884133672 scopus 로고    scopus 로고
    • Whole-genome bisulfite sequencing of two distinct interconvertible DNA methylomes of mouse embryonic stem cells
    • Habibi E, Brinkman AB, Arand J, Kroeze LI, Kerstens HHD, et al. 2013. Whole-genome bisulfite sequencing of two distinct interconvertible DNA methylomes of mouse embryonic stem cells. Cell Stem Cell 13(3):360-69
    • (2013) Cell Stem Cell , vol.13 , Issue.3 , pp. 360-369
    • Habibi, E.1    Brinkman, A.B.2    Arand, J.3    Kroeze, L.I.4    Kerstens, H.H.D.5
  • 67
    • 10944241060 scopus 로고    scopus 로고
    • Aggregation of embryonic stem cells induces Nanog repression and primitive endoderm differentiation
    • Hamazaki T, Oka M, Yamanaka S, Terada N. 2004. Aggregation of embryonic stem cells induces Nanog repression and primitive endoderm differentiation. J. Cell Sci. 117(Pt 23):5681-86
    • (2004) J. Cell Sci , vol.117 , pp. 5681-5686
    • Hamazaki, T.1    Oka, M.2    Yamanaka, S.3    Terada, N.4
  • 68
    • 84919844060 scopus 로고    scopus 로고
    • Erk signaling suppresses embryonic stem cell self-renewal to specify endoderm
    • Hamilton WB, Brickman JM. 2014. Erk signaling suppresses embryonic stem cell self-renewal to specify endoderm. Cell Rep. 9(6):2056-70
    • (2014) Cell Rep , vol.9 , Issue.6 , pp. 2056-2070
    • Hamilton, W.B.1    Brickman, J.M.2
  • 69
    • 84883447620 scopus 로고    scopus 로고
    • Allele-specific detection of single mRNA molecules in situ
    • Hansen CH, van Oudenaarden A. 2013. Allele-specific detection of single mRNA molecules in situ. Nat. Methods 10(9):869-71
    • (2013) Nat. Methods , vol.10 , Issue.9 , pp. 869-871
    • Hansen, C.H.1    Van Oudenaarden, A.2
  • 70
    • 53049092465 scopus 로고    scopus 로고
    • Dynamic equilibrium and heterogeneity of mouse pluripotent stem cells with distinct functional and epigenetic states
    • Hayashi K, Chuva de Sousa Lopes SM, Tang F, Surani MA. 2008. Dynamic equilibrium and heterogeneity of mouse pluripotent stem cells with distinct functional and epigenetic states. Cell Stem Cell 3(4):391-401
    • (2008) Cell Stem Cell , vol.3 , Issue.4 , pp. 391-401
    • Hayashi, K.1    Chuva De Sousa Lopes, S.M.2    Tang, F.3    Surani, M.A.4
  • 71
    • 84888015137 scopus 로고    scopus 로고
    • Super-enhancers in the control of cell identity and disease
    • Hnisz D, Abraham BJ, Lee TI, Lau A, Saint-Andre V, et al. 2013. Super-enhancers in the control of cell identity and disease. Cell 155(4):934-47
    • (2013) Cell , vol.155 , Issue.4 , pp. 934-947
    • Hnisz, D.1    Abraham, B.J.2    Lee, T.I.3    Lau, A.4    Saint-Andre, V.5
  • 72
    • 79960009805 scopus 로고    scopus 로고
    • Cell fate potential of human pluripotent stem cells is encoded by histone modifications
    • Hong S-H, Rampalli S, Lee JB, McNicol J, Collins T, et al. 2011. Cell fate potential of human pluripotent stem cells is encoded by histone modifications. Cell Stem Cell 9(1):24-36
    • (2011) Cell Stem Cell , vol.9 , Issue.1 , pp. 24-36
    • Hong, S.-H.1    Rampalli, S.2    Lee, J.B.3    McNicol, J.4    Collins, T.5
  • 73
    • 84922012748 scopus 로고    scopus 로고
    • Single-cell technologies sharpen upmammalian stem cell research
    • Hoppe PS, CoutuDL, Schroeder T. 2014. Single-cell technologies sharpen upmammalian stem cell research. Nat. Cell Biol. 16(10):919-27
    • (2014) Nat. Cell Biol , vol.16 , Issue.10 , pp. 919-927
    • Hoppe, P.S.1    Coutu, D.L.2    Schroeder, T.3
  • 74
    • 84902259602 scopus 로고    scopus 로고
    • Single-cell gene expression profiles define self-renewing, pluripotent, and lineage primed states of human pluripotent stem cells
    • Hough SR, Thornton M, Mason E, Mar JC, Wells CA, Pera MF. 2014. Single-cell gene expression profiles define self-renewing, pluripotent, and lineage primed states of human pluripotent stem cells. Stem Cell Rep. 2(6):881-95
    • (2014) Stem Cell Rep , vol.2 , Issue.6 , pp. 881-895
    • Hough, S.R.1    Thornton, M.2    Mason, E.3    Mar, J.C.4    Wells, C.A.5    Pera, M.F.6
  • 75
    • 18144408736 scopus 로고    scopus 로고
    • Cell fates as high-dimensional attractor states of a complex gene regulatory network
    • Huang S, EichlerG, Bar-Yam Y, IngberDE. 2005. Cell fates as high-dimensional attractor states of a complex gene regulatory network. Phys. Rev. Lett. 94(12):128701
    • (2005) Phys. Rev. Lett , vol.94 , Issue.12 , pp. 128701
    • Huang, S.1    Eichler, G.2    Bar-Yam, Y.3    Ingber, D.E.4
  • 76
    • 34248199004 scopus 로고    scopus 로고
    • Bifurcation dynamics in lineage-commitment in bipotent progenitor cells
    • Huang S,Guo Y, MayG, Enver T. 2007. Bifurcation dynamics in lineage-commitment in bipotent progenitor cells. Dev. Biol. 305(2):695-713
    • (2007) Dev. Biol , vol.305 , Issue.2 , pp. 695-713
    • Huang, S.1    Guo, Y.2    May, G.3    Enver, T.4
  • 77
    • 84899453635 scopus 로고    scopus 로고
    • Complex gene regulatory networks-from structure to biological observables: Cell fate determination
    • ed. RA Meyers. New York: Springer
    • Huang S, Kauffman SA. 2012. Complex gene regulatory networks-from structure to biological observables: cell fate determination. In Computational Complexity, ed. RA Meyers, pp. 527-60. New York: Springer
    • (2012) Computational Complexity , pp. 527-560
    • Huang, S.1    Kauffman, S.A.2
  • 78
    • 80052565008 scopus 로고    scopus 로고
    • Random partitioning of molecules at cell division
    • Huh D, Paulsson J. 2011. Random partitioning of molecules at cell division. PNAS 108(36):15004-9
    • (2011) PNAS , vol.108 , Issue.36 , pp. 15004-15009
    • Huh, D.1    Paulsson, J.2
  • 79
    • 84889261444 scopus 로고    scopus 로고
    • Oscillatory control of factors determining multipotency and fate in mouse neural progenitors
    • Imayoshi I, Isomura A, Harima Y, Kawaguchi K, Kori H, et al. 2013. Oscillatory control of factors determining multipotency and fate in mouse neural progenitors. Science 342(6163):1203-8
    • (2013) Science , vol.342 , Issue.6163 , pp. 1203-1208
    • Imayoshi, I.1    Isomura, A.2    Harima, Y.3    Kawaguchi, K.4    Kori, H.5
  • 80
    • 33746773659 scopus 로고    scopus 로고
    • Dissecting self-renewal in stem cells with RNA interference
    • Ivanova N, Dobrin R, Lu R, Kotenko I, Levorse J, et al. 2006. Dissecting self-renewal in stem cells with RNA interference. Nature 442(7102):533-38
    • (2006) Nature , vol.442 , Issue.7102 , pp. 533-538
    • Ivanova, N.1    Dobrin, R.2    Lu, R.3    Kotenko, I.4    Levorse, J.5
  • 81
    • 77956271471 scopus 로고    scopus 로고
    • Differentiating embryonic stem cells pass through 'temporal windows' that mark responsiveness to exogenous and paracrinemesendoderm inducing signals
    • Jackson SA, Schiesser J, Stanley EG, Elefanty AG. 2010. Differentiating embryonic stem cells pass through 'temporal windows' that mark responsiveness to exogenous and paracrinemesendoderm inducing signals. PLOS ONE 5(5):e10706
    • (2010) PLOS ONE , vol.5 , Issue.5 , pp. e10706
    • Jackson, S.A.1    Schiesser, J.2    Stanley, E.G.3    Elefanty, A.G.4
  • 82
    • 39149130361 scopus 로고    scopus 로고
    • Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming
    • Jaenisch R, Young R. 2008. Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming. Cell 132(4):567-82
    • (2008) Cell , vol.132 , Issue.4 , pp. 567-582
    • Jaenisch, R.1    Young, R.2
  • 83
    • 84893905629 scopus 로고    scopus 로고
    • Massively parallel single-cell RNA-seq for marker-free decomposition of tissues into cell types
    • Jaitin DA, Kenigsberg E, Keren-Shaul H, ElefantN, Paul F, et al. 2014. Massively parallel single-cell RNA-seq for marker-free decomposition of tissues into cell types. Science 343(6172):776-79
    • (2014) Science , vol.343 , Issue.6172 , pp. 776-779
    • Jaitin, D.A.1    Kenigsberg, E.2    Keren-Shaul, H.3    Elefant, N.4    Paul, F.5
  • 84
    • 84857382784 scopus 로고    scopus 로고
    • When noisy neighbors are a blessing: Analysis of gene expression noise identifies coregulated genes
    • Junker JP, van Oudenaarden A. 2012. When noisy neighbors are a blessing: Analysis of gene expression noise identifies coregulated genes. Mol. Cell 45(4):437-38
    • (2012) Mol. Cell , vol.45 , Issue.4 , pp. 437-438
    • Junker, J.P.1    Van Oudenaarden, A.2
  • 85
    • 84897139457 scopus 로고    scopus 로고
    • Every cell is special: Genome-wide studies add a new dimension to single-cell biology
    • Junker JP, van Oudenaarden A. 2014. Every cell is special: Genome-wide studies add a new dimension to single-cell biology. Cell 157(1):8-11
    • (2014) Cell , vol.157 , Issue.1 , pp. 8-11
    • Junker, J.P.1    Van Oudenaarden, A.2
  • 86
    • 84908247678 scopus 로고    scopus 로고
    • Mapping the route from naive pluripotency to lineage specification
    • Kalkan T, Smith A. 2014. Mapping the route from naive pluripotency to lineage specification. Philos. Trans. R. Soc. B 369(1657):20130540
    • (2014) Philos. Trans. R. Soc. B , vol.369 , Issue.1657 , pp. 20130540
    • Kalkan, T.1    Smith, A.2
  • 87
    • 68049139696 scopus 로고    scopus 로고
    • Regulated fluctuations in Nanog expression mediate cell fate decisions in embryonic stem cells
    • Kalmar T, Lim C, Hayward P, Mu noz-Descalzo S, Nichols J, et al. 2009. Regulated fluctuations in Nanog expression mediate cell fate decisions in embryonic stem cells. PLOS Biol. 7(7):e1000149
    • (2009) PLOS Biol , vol.7 , Issue.7 , pp. e1000149
    • Kalmar, T.1    Lim, C.2    Hayward, P.3    Mu noz-Descalzo, S.4    Nichols, J.5
  • 88
    • 40749104852 scopus 로고    scopus 로고
    • An extended transcriptional network for pluripotency of embryonic stem cells
    • Kim J, Chu J, Shen X, Wang J, Orkin SH. 2008. An extended transcriptional network for pluripotency of embryonic stem cells. Cell 132(6):1049-61
    • (2008) Cell , vol.132 , Issue.6 , pp. 1049-1061
    • Kim, J.1    Chu, J.2    Shen, X.3    Wang, J.4    Orkin, S.H.5
  • 89
    • 63349094725 scopus 로고    scopus 로고
    • Regulation of mouse embryonic stem cell neural differentiation by retinoic acid
    • Kim M, Habiba A, Doherty JM, Mills JC, Mercer RW, Huettner JE. 2009. Regulation of mouse embryonic stem cell neural differentiation by retinoic acid. Dev. Biol. 328(2):456-71
    • (2009) Dev. Biol , vol.328 , Issue.2 , pp. 456-471
    • Kim, M.1    Habiba, A.2    Doherty, J.M.3    Mills, J.C.4    Mercer, R.W.5    Huettner, J.E.6
  • 90
    • 77952367798 scopus 로고    scopus 로고
    • Widespread transcription at neuronal activity-regulated enhancers
    • Kim T-K, Hemberg M, Gray JM, Costa AM, Bear DM, et al. 2010. Widespread transcription at neuronal activity-regulated enhancers. Nature 465(7295):182-87
    • (2010) Nature , vol.465 , Issue.7295 , pp. 182-187
    • Kim, T.-K.1    Hemberg, M.2    Gray, J.M.3    Costa, A.M.4    Bear, D.M.5
  • 91
    • 84873300214 scopus 로고    scopus 로고
    • Braveheart, a long noncoding RNA required for cardiovascular lineage commitment
    • Klattenhoff CA, Scheuermann JC, Surface LE, BradleyRK, Fields PA, et al. 2013. Braveheart, a long noncoding RNA required for cardiovascular lineage commitment. Cell 152(3):570-83
    • (2013) Cell , vol.152 , Issue.3 , pp. 570-583
    • Klattenhoff, C.A.1    Scheuermann, J.C.2    Surface, L.E.3    Bradley, R.K.4    Fields, P.A.5
  • 92
    • 84929684998 scopus 로고    scopus 로고
    • Droplet barcoding for single-cell transcriptomics applied to embryonic stem cells
    • Klein AM, Mazutis L, Akartuna I, Tallapragada N, Veres A, et al. 2015. Droplet barcoding for single-cell transcriptomics applied to embryonic stem cells. Cell 161(5):1187-1201
    • (2015) Cell , vol.161 , Issue.5 , pp. 1187-1201
    • Klein, A.M.1    Mazutis, L.2    Akartuna, I.3    Tallapragada, N.4    Veres, A.5
  • 94
    • 69249215528 scopus 로고    scopus 로고
    • The cyclic gene Hes1 contributes to diverse differentiation responses of embryonic stem cells
    • Kobayashi T, Mizuno H, Imayoshi I, Furusawa C, Shirahige K, Kageyama R. 2009. The cyclic gene Hes1 contributes to diverse differentiation responses of embryonic stem cells. Gene Dev. 23(16):1870-75
    • (2009) Gene Dev , vol.23 , Issue.16 , pp. 1870-1875
    • Kobayashi, T.1    Mizuno, H.2    Imayoshi, I.3    Furusawa, C.4    Shirahige, K.5    Kageyama, R.6
  • 95
    • 84898665052 scopus 로고    scopus 로고
    • Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library
    • Koike-Yusa H, Li Y, Tan E-P, Velasco-Herrera MDC, Yusa K. 2013. Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library. Nat. Biotechnol. 32(3):267-73
    • (2013) Nat. Biotechnol , vol.32 , Issue.3 , pp. 267-273
    • Koike-Yusa, H.1    Li, Y.2    Tan, E.-P.3    Velasco-Herrera, M.D.C.4    Yusa, K.5
  • 96
    • 84923188586 scopus 로고    scopus 로고
    • Deconstructing transcriptional heterogeneity in pluripotent stem cells
    • Kumar RM, Cahan P, Shalek AK, Satija R, DaleyKeyser AJ, et al. 2014. Deconstructing transcriptional heterogeneity in pluripotent stem cells. Nature 516(7529):56-61
    • (2014) Nature , vol.516 , Issue.7529 , pp. 56-61
    • Kumar, R.M.1    Cahan, P.2    Shalek, A.K.3    Satija, R.4    DaleyKeyser, A.J.5
  • 97
    • 34548587064 scopus 로고    scopus 로고
    • FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment
    • Kunath T, Saba-El-Leil MK, Almousailleakh M,Wray J, Meloche S, Smith A. 2007. FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment. Development 134(16):2895-902
    • (2007) Development , vol.134 , Issue.16 , pp. 2895-2902
    • Kunath, T.1    Saba-El-Leil, M.K.2    Almousailleakh, M.3    Wray, J.4    Meloche, S.5    Smith, A.6
  • 98
    • 84884414984 scopus 로고    scopus 로고
    • Cerebral organoids model human brain development and microcephaly
    • LancasterMA, RennerM,Martin C-A,Wenzel D, Bicknell LS, et al. 2013. Cerebral organoids model human brain development and microcephaly. Nature 501(7467):373-79
    • (2013) Nature , vol.501 , Issue.7467 , pp. 373-379
    • Lancaster, M.A.1    Renner, M.2    Martin, C.-A.3    Wenzel, D.4    Bicknell, L.S.5
  • 99
    • 84897090228 scopus 로고    scopus 로고
    • Highly multiplexed subcellular RNA sequencing in situ
    • Lee JH, Daugharthy ER, Scheiman J, Kalhor R, Yang JL, et al. 2014. Highly multiplexed subcellular RNA sequencing in situ. Science 343(6177):1360-63
    • (2014) Science , vol.343 , Issue.6177 , pp. 1360-1363
    • Lee, J.H.1    Daugharthy, E.R.2    Scheiman, J.3    Kalhor, R.4    Yang, J.L.5
  • 100
    • 84875198920 scopus 로고    scopus 로고
    • Transcriptional regulation and its misregulation in disease
    • Lee TI, Young RA. 2013. Transcriptional regulation and its misregulation in disease. Cell 152(6):1237-51
    • (2013) Cell , vol.152 , Issue.6 , pp. 1237-1251
    • Lee, T.I.1    Young, R.A.2
  • 101
    • 84896120165 scopus 로고    scopus 로고
    • Genetic exploration of the exit from self-renewal using haploid embryonic stem cells
    • Leeb M, Dietmann S, ParamorM, Niwa H, Smith A. 2014. Genetic exploration of the exit from self-renewal using haploid embryonic stem cells. Cell Stem Cell 14(3):385-93
    • (2014) Cell Stem Cell , vol.14 , Issue.3 , pp. 385-393
    • Leeb, M.1    Dietmann, S.2    Paramor, M.3    Niwa, H.4    Smith, A.5
  • 103
    • 84903729538 scopus 로고    scopus 로고
    • Molecular ties between the cell cycle and differentiation in embryonic stem cells
    • Li VC, Kirschner MW. 2014. Molecular ties between the cell cycle and differentiation in embryonic stem cells. PNAS 111(26):9503-8
    • (2014) PNAS , vol.111 , Issue.26 , pp. 9503-9508
    • Li, V.C.1    Kirschner, M.W.2
  • 104
    • 84893794554 scopus 로고    scopus 로고
    • Efficient endoderm induction from human pluripotent stem cells by logically directing signals controlling lineage bifurcations
    • Loh KM, Ang LT, Zhang J, Kumar V, Ang J, et al. 2014. Efficient endoderm induction from human pluripotent stem cells by logically directing signals controlling lineage bifurcations. Cell Stem Cell 14(2):237-52
    • (2014) Cell Stem Cell , vol.14 , Issue.2 , pp. 237-252
    • Loh, K.M.1    Ang, L.T.2    Zhang, J.3    Kumar, V.4    Ang, J.5
  • 105
    • 79953847687 scopus 로고    scopus 로고
    • A precarious balance: Pluripotency factors as lineage specifiers
    • Loh KM, Lim B. 2011. A precarious balance: pluripotency factors as lineage specifiers. Cell Stem Cell 8(4):363-69
    • (2011) Cell Stem Cell , vol.8 , Issue.4 , pp. 363-369
    • Loh, K.M.1    Lim, B.2
  • 106
    • 33645381936 scopus 로고    scopus 로고
    • The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells
    • Loh Y-H, Wu Q, Chew J-L, Vega VB, Zhang W, et al. 2006. The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat. Genet. 38(4):431-40
    • (2006) Nat. Genet , vol.38 , Issue.4 , pp. 431-440
    • Loh, Y.-H.1    Wu, Q.2    Chew, J.-L.3    Vega, V.B.4    Zhang, W.5
  • 107
    • 70450160004 scopus 로고    scopus 로고
    • Systems-level dynamic analyses of fate change in murine embryonic stem cells
    • Lu R, Markowetz F, Unwin RD, Leek JT, Airoldi EM, et al. 2009. Systems-level dynamic analyses of fate change in murine embryonic stem cells. Nature 462(7271):358-62
    • (2009) Nature , vol.462 , Issue.7271 , pp. 358-362
    • Lu, R.1    Markowetz, F.2    Unwin, R.D.3    Leek, J.T.4    Airoldi, E.M.5
  • 108
    • 84881171093 scopus 로고    scopus 로고
    • Statistical mechanics of pluripotency
    • MacArthur BD, Lemischka IR. 2013. Statistical mechanics of pluripotency. Cell 154(3):484-89
    • (2013) Cell , vol.154 , Issue.3 , pp. 484-489
    • MacArthur, B.D.1    Lemischka, I.R.2
  • 109
  • 110
    • 84863458292 scopus 로고    scopus 로고
    • Embryonic stem cell potency fluctuates with endogenous retrovirus activity
    • Macfarlan TS, Gifford WD, Driscoll S, Lettieri K, Rowe HM, et al. 2012. Embryonic stem cell potency fluctuates with endogenous retrovirus activity. Nature 487(7405):57-63
    • (2012) Nature , vol.487 , Issue.7405 , pp. 57-63
    • Macfarlan, T.S.1    Gifford, W.D.2    Driscoll, S.3    Lettieri, K.4    Rowe, H.M.5
  • 111
    • 84929684999 scopus 로고    scopus 로고
    • Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets
    • Macosko EZ, Basu A, Satija R, Nemesh J, Shekhar K, et al. 2015. Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets. Cell 161(5):1202-14
    • (2015) Cell , vol.161 , Issue.5 , pp. 1202-1214
    • Macosko, E.Z.1    Basu, A.2    Satija, R.3    Nemesh, J.4    Shekhar, K.5
  • 112
    • 80054084614 scopus 로고    scopus 로고
    • Pioneer factors: Directing transcriptional regulators within the chromatin environment
    • Magnani L, Eeckhoute J, Lupien M. 2011. Pioneer factors: directing transcriptional regulators within the chromatin environment. Trends Genet. 27(11):465-74
    • (2011) Trends Genet , vol.27 , Issue.11 , pp. 465-474
    • Magnani, L.1    Eeckhoute, J.2    Lupien, M.3
  • 114
    • 84924365758 scopus 로고    scopus 로고
    • Bifurcation analysis of single-cell gene expression data reveals epigenetic landscape
    • Marco E, Karp RL, GuoG, Robson P, Hart AH, et al. 2014. Bifurcation analysis of single-cell gene expression data reveals epigenetic landscape. PNAS 111(52):E5643-50
    • (2014) PNAS , vol.111 , Issue.52 , pp. E5643-E5650
    • Marco, E.1    Karp, R.L.2    Guo, G.3    Robson, P.4    Hart, A.H.5
  • 115
    • 48449084118 scopus 로고    scopus 로고
    • Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells
    • Marson A, Levine SS, Cole MF, Frampton GM, Brambrink T, et al. 2008. Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. Cell 134(3):521-33
    • (2008) Cell , vol.134 , Issue.3 , pp. 521-533
    • Marson, A.1    Levine, S.S.2    Cole, M.F.3    Frampton, G.M.4    Brambrink, T.5
  • 116
    • 82555169760 scopus 로고    scopus 로고
    • Gene expression heterogeneities in embryonic stem cell populations: Origin and function
    • Martinez Arias A, Brickman JM. 2011. Gene expression heterogeneities in embryonic stem cell populations: origin and function. Curr. Opin. Cell Biol. 23(6):650-56
    • (2011) Curr. Opin. Cell Biol , vol.23 , Issue.6 , pp. 650-656
    • Martinez, A.A.1    Brickman, J.M.2
  • 117
    • 84923777711 scopus 로고    scopus 로고
    • 3D reconstitution of the patterned neural tube from embryonic stem cells
    • Meinhardt A, Eberle D, Tazaki A, Ranga A, NiescheM, et al. 2014. 3D reconstitution of the patterned neural tube from embryonic stem cells. Stem Cell Rep. 3(6):987-99
    • (2014) Stem Cell Rep , vol.3 , Issue.6 , pp. 987-999
    • Meinhardt, A.1    Eberle, D.2    Tazaki, A.3    Ranga, A.4    Niesche, M.5
  • 118
    • 76249119007 scopus 로고    scopus 로고
    • Opposing microRNA families regulate self-renewal in mouse embryonic stem cells
    • Melton C, Judson RL, Blelloch R. 2010. Opposing microRNA families regulate self-renewal in mouse embryonic stem cells. Nature 463(7281):621-26
    • (2010) Nature , vol.463 , Issue.7281 , pp. 621-626
    • Melton, C.1    Judson, R.L.2    Blelloch, R.3
  • 119
    • 80054088836 scopus 로고    scopus 로고
    • Dissecting the retinoid-induced differentiation of F9 embryonal stem cells by integrative genomics
    • Mendoza-Parra MA, Walia M, Sankar M, Gronemeyer H. 2011. Dissecting the retinoid-induced differentiation of F9 embryonal stem cells by integrative genomics. Mol. Syst. Biol. 7:538
    • (2011) Mol. Syst. Biol , vol.7 , pp. 538
    • Mendoza-Parra, M.A.1    Walia, M.2    Sankar, M.3    Gronemeyer, H.4
  • 120
    • 34547624303 scopus 로고    scopus 로고
    • Genome-wide maps of chromatin state in pluripotent and lineage-committed cells
    • Mikkelsen TS, Ku M, Jaffe DB, Issac B, Lieberman E, et al. 2007. Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature 448(7153):553-60
    • (2007) Nature , vol.448 , Issue.7153 , pp. 553-560
    • Mikkelsen, T.S.1    Ku, M.2    Jaffe, D.B.3    Issac, B.4    Lieberman, E.5
  • 121
    • 0037174670 scopus 로고    scopus 로고
    • Network motifs: Simple building blocks of complex networks
    • Milo R. 2002. Network motifs: simple building blocks of complex networks. Science 298(5594):824-27
    • (2002) Science , vol.298 , Issue.5594 , pp. 824-827
    • Milo, R.1
  • 122
    • 84858800729 scopus 로고    scopus 로고
    • Control of ground-state pluripotency by allelic regulation of Nanog
    • Miyanari Y, Torres-Padilla M-E. 2012. Control of ground-state pluripotency by allelic regulation of Nanog. Nature 483(7390):470-73
    • (2012) Nature , vol.483 , Issue.7390 , pp. 470-473
    • Miyanari, Y.1    Torres-Padilla, M.-E.2
  • 123
    • 84908245609 scopus 로고    scopus 로고
    • The molecular underpinnings of totipotency
    • Morgani SM, Brickman JM. 2014. The molecular underpinnings of totipotency. Philos. Trans. R. Soc. B 369(1657):20130549
    • (2014) Philos. Trans. R. Soc. B , vol.369 , Issue.1657 , pp. 20130549
    • Morgani, S.M.1    Brickman, J.M.2
  • 124
    • 84879796179 scopus 로고    scopus 로고
    • Totipotent embryonic stem cells arise in ground-state culture conditions
    • Morgani SM, CanhamMA, Nichols J, Sharov AA, Migueles RP, et al. 2013. Totipotent embryonic stem cells arise in ground-state culture conditions. Cell Rep. 3(6):1945-57
    • (2013) Cell Rep , vol.3 , Issue.6 , pp. 1945-1957
    • Morgani, S.M.1    Canham, M.A.2    Nichols, J.3    Sharov, A.A.4    Migueles, R.P.5
  • 125
    • 84901004299 scopus 로고    scopus 로고
    • The rise of regulatory RNA
    • Morris KV, Mattick JS. 2014. The rise of regulatory RNA. Nat. Rev. Genet. 15(6):423-37
    • (2014) Nat. Rev. Genet , vol.15 , Issue.6 , pp. 423-437
    • Morris, K.V.1    Mattick, J.S.2
  • 126
    • 84908431507 scopus 로고    scopus 로고
    • Dissecting engineered cell types and enhancing cell fate conversion via CellNet
    • Morris SA, Cahan P, Li H, Zhao AM, San Roman AK, et al. 2014. Dissecting engineered cell types and enhancing cell fate conversion via CellNet. Cell 158(4):889-902
    • (2014) Cell , vol.158 , Issue.4 , pp. 889-902
    • Morris, S.A.1    Cahan, P.2    Li, H.3    Zhao, A.M.4    San, R.A.K.5
  • 127
    • 80155137594 scopus 로고    scopus 로고
    • Master transcription factors determine cell-type-specific responses to TGF-βsignaling
    • Mullen AC, Orlando DA, Newman JJ, Loven J, Kumar RM, et al. 2011. Master transcription factors determine cell-type-specific responses to TGF-βsignaling. Cell 147(3):565-76
    • (2011) Cell , vol.147 , Issue.3 , pp. 565-576
    • Mullen, A.C.1    Orlando, D.A.2    Newman, J.J.3    Loven, J.4    Kumar, R.M.5
  • 128
    • 0023094605 scopus 로고
    • Cell cycle analysis during retinoic acid induced differentiation of a human embryonal carcinoma-derived cell line
    • Mummery CL, van RooijenMA, van den Brink SE, de Laat SW. 1987. Cell cycle analysis during retinoic acid induced differentiation of a human embryonal carcinoma-derived cell line. Cell Differ. 20(2-3):153-60
    • (1987) Cell Differ , vol.20 , Issue.2-3 , pp. 153-160
    • Mummery, C.L.1    Van Rooijen, M.A.2    Van Den Brink, S.E.3    De Laat, S.W.4
  • 129
    • 84859641038 scopus 로고    scopus 로고
    • Using gene expression noise to understand gene regulation
    • Munsky B, Neuert G, van Oudenaarden A. 2012. Using gene expression noise to understand gene regulation. Science 336(6078):183-87
    • (2012) Science , vol.336 , Issue.6078 , pp. 183-187
    • Munsky, B.1    Neuert, G.2    Van Oudenaarden, A.3
  • 130
    • 39349106325 scopus 로고    scopus 로고
    • Differentiation of embryonic stem cells to clinically relevant populations: Lessons from embryonic development
    • Murry CE, Keller G. 2008. Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development. Cell Stem Cell 132(4):661-80
    • (2008) Cell Stem Cell , vol.132 , Issue.4 , pp. 661-680
    • Murry, C.E.1    Keller, G.2
  • 131
    • 84888870688 scopus 로고    scopus 로고
    • High-throughput fingerprinting of human pluripotent stem cell fate responses and lineage bias
    • Nazareth EJP, Ostblom JEE, Lucker PB, Shukla S, Alvarez MM, et al. 2013. High-throughput fingerprinting of human pluripotent stem cell fate responses and lineage bias. Nat. Methods 10(12):1225-31
    • (2013) Nat. Methods , vol.10 , Issue.12 , pp. 1225-1231
    • Nazareth, E.J.P.1    Ostblom, J.E.E.2    Lucker, P.B.3    Shukla, S.4    Alvarez, M.M.5
  • 132
    • 66049117813 scopus 로고    scopus 로고
    • Naive and primed pluripotent states
    • Nichols J, Smith A. 2009. Naive and primed pluripotent states. Stem Cell 4(6):487-92
    • (2009) Stem Cell , vol.4 , Issue.6 , pp. 487-492
    • Nichols, J.1    Smith, A.2
  • 133
    • 67650032868 scopus 로고    scopus 로고
    • A parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells
    • Niwa H, Ogawa K, Shimosato D, Adachi K. 2009. A parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells. Nature 460(7251):118-22
    • (2009) Nature , vol.460 , Issue.7251 , pp. 118-122
    • Niwa, H.1    Ogawa, K.2    Shimosato, D.3    Adachi, K.4
  • 134
    • 77954920254 scopus 로고    scopus 로고
    • Population robustness arising from cellular heterogeneity
    • Paszek P, Ryan S, Ashall L, Sillitoe K, Harper CV, et al. 2010. Population robustness arising from cellular heterogeneity. PNAS 107(25):11644-49
    • (2010) PNAS , vol.107 , Issue.25 , pp. 11644-11649
    • Paszek, P.1    Ryan, S.2    Ashall, L.3    Sillitoe, K.4    Harper, C.V.5
  • 135
    • 84884844190 scopus 로고    scopus 로고
    • The cell-cycle state of stem cells determines cell fate propensity
    • Pauklin S, Vallier L. 2013. The cell-cycle state of stem cells determines cell fate propensity. Cell 155(1):135-47
    • (2013) Cell , vol.155 , Issue.1 , pp. 135-147
    • Pauklin, S.1    Vallier, L.2
  • 136
    • 15544388848 scopus 로고    scopus 로고
    • Noise propagation in gene networks
    • Pedraza JM. 2005. Noise propagation in gene networks. Science 307(5717):1965-69
    • (2005) Science , vol.307 , Issue.5717 , pp. 1965-1969
    • Pedraza, J.M.1
  • 137
    • 77953365784 scopus 로고    scopus 로고
    • Extrinsic regulation of pluripotent stem cells
    • Pera MF, Tam PPL. 2010. Extrinsic regulation of pluripotent stem cells. Nature 465(7299):713-20
    • (2010) Nature , vol.465 , Issue.7299 , pp. 713-720
    • Pera, M.F.1    Tam, P.P.L.2
  • 138
    • 0028014396 scopus 로고
    • Retinoic acid represses Oct-3/4 gene expression through several retinoic acid-responsive elements located in the promoter-enhancer region
    • Pikarsky E, Sharir H, Ben-Shushan E, Bergman Y. 1994. Retinoic acid represses Oct-3/4 gene expression through several retinoic acid-responsive elements located in the promoter-enhancer region. Mol. Cell. Biol. 14(2):1026-38
    • (1994) Mol. Cell. Biol , vol.14 , Issue.2 , pp. 1026-1038
    • Pikarsky, E.1    Sharir, H.2    Ben-Shushan, E.3    Bergman, Y.4
  • 139
    • 84862778068 scopus 로고    scopus 로고
    • Inferring rules of lineage commitment in haematopoiesis
    • Pina C, Fugazza C, Tipping AJ, Brown J, Soneji S, et al. 2012. Inferring rules of lineage commitment in haematopoiesis. Nat. Cell Biol. 14(3):287-94
    • (2012) Nat. Cell Biol , vol.14 , Issue.3 , pp. 287-294
    • Pina, C.1    Fugazza, C.2    Tipping, A.J.3    Brown, J.4    Soneji, S.5
  • 140
    • 84922321862 scopus 로고    scopus 로고
    • Low-coverage single-cell mRNA sequencing reveals cellular heterogeneity and activated signaling pathways in developing cerebral cortex
    • Pollen AA, Nowakowski TJ, Shuga J, Wang X, Leyrat AA, et al. 2014. Low-coverage single-cell mRNA sequencing reveals cellular heterogeneity and activated signaling pathways in developing cerebral cortex. Nat. Biotechnol. 32(10):1053-58
    • (2014) Nat. Biotechnol , vol.32 , Issue.10 , pp. 1053-1058
    • Pollen, A.A.1    Nowakowski, T.J.2    Shuga, J.3    Wang, X.4    Leyrat, A.A.5
  • 141
    • 84905393913 scopus 로고    scopus 로고
    • Intercellular network structure and regulatory motifs in the human hematopoietic system
    • Qiao W, Wang W, Laurenti E, Turinsky AL, Wodak SJ, et al. 2014. Intercellular network structure and regulatory motifs in the human hematopoietic system. Mol. Syst. Biol. 10(7):741
    • (2014) Mol. Syst. Biol , vol.10 , Issue.7 , pp. 741
    • Qiao, W.1    Wang, W.2    Laurenti, E.3    Turinsky, A.L.4    Wodak, S.J.5
  • 142
    • 80054768631 scopus 로고    scopus 로고
    • Extracting a cellular hierarchy from high-dimensional cytometry data with SPADE
    • Qiu P, Simonds EF, Bendall SC, Gibbs KD Jr, Bruggner RV, et al. 2011. Extracting a cellular hierarchy from high-dimensional cytometry data with SPADE. Nat. Biotechnol. 29(10):886-91
    • (2011) Nat. Biotechnol , vol.29 , Issue.10 , pp. 886-891
    • Qiu, P.1    Simonds, E.F.2    Bendall, S.C.3    Gibbs, K.D.4    Bruggner, R.V.5
  • 143
    • 84923638273 scopus 로고    scopus 로고
    • Long noncoding RNAs: An emerging link between gene regulation and nuclear organization
    • Quinodoz S, Guttman M. 2014. Long noncoding RNAs: an emerging link between gene regulation and nuclear organization. Trends Cell Biol. 24(11):651-63
    • (2014) Trends Cell Biol , vol.24 , Issue.11 , pp. 651-663
    • Quinodoz, S.1    Guttman, M.2
  • 145
    • 53549123008 scopus 로고    scopus 로고
    • Nature, nurture, or chance: Stochastic gene expression and its consequences
    • Raj A, van Oudenaarden A. 2008. Nature, nurture, or chance: stochastic gene expression and its consequences. Cell 135(2):216-26
    • (2008) Cell , vol.135 , Issue.2 , pp. 216-226
    • Raj, A.1    Van Oudenaarden, A.2
  • 146
    • 84856745520 scopus 로고    scopus 로고
    • Retinoic acid signalling during development
    • Rhinn M, Dolle P. 2012. Retinoic acid signalling during development. Development 139(5):843-58
    • (2012) Development , vol.139 , Issue.5 , pp. 843-858
    • Rhinn, M.1    Dolle, P.2
  • 148
    • 42649126705 scopus 로고    scopus 로고
    • A hierarchical network controls protein translation during murine embryonic stem cell self-renewal and differentiation
    • Sampath P, Pritchard D, Pabon L, Reinecke H, Schwartz S, et al. 2008. A hierarchical network controls protein translation during murine embryonic stem cell self-renewal and differentiation. Cell Stem Cell 2(5):448-60
    • (2008) Cell Stem Cell , vol.2 , Issue.5 , pp. 448-460
    • Sampath, P.1    Pritchard, D.2    Pabon, L.3    Reinecke, H.4    Schwartz, S.5
  • 149
    • 67349123408 scopus 로고    scopus 로고
    • Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
    • Sato T, Vries RG, Snippert HJ, van de Wetering M, Barker N, et al. 2009. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature 459(7244):262-65
    • (2009) Nature , vol.459 , Issue.7244 , pp. 262-265
    • Sato, T.1    Vries, R.G.2    Snippert, H.J.3    Van De Wetering, M.4    Barker, N.5
  • 151
    • 84922621952 scopus 로고    scopus 로고
    • Function and information content of DNA methylation
    • Schubeler D. 2015. Function and information content of DNA methylation. Nature 517(7534):321-26
    • (2015) Nature , vol.517 , Issue.7534 , pp. 321-326
    • Schubeler, D.1
  • 152
    • 84882455458 scopus 로고    scopus 로고
    • Single-cell sequencing-based technologies will revolutionize whole-organism science
    • Shapiro E, Biezuner T, Linnarsson S. 2013. Single-cell sequencing-based technologies will revolutionize whole-organism science. Nat. Rev. Genet. 14(9):618-30
    • (2013) Nat. Rev. Genet , vol.14 , Issue.9 , pp. 618-630
    • Shapiro, E.1    Biezuner, T.2    Linnarsson, S.3
  • 153
    • 84907207898 scopus 로고    scopus 로고
    • Dynamic and static maintenance of epigenetic memory in pluripotent and somatic cells
    • Shipony Z, Mukamel Z, Cohen NM, Landan G, Chomsky E, et al. 2014. Dynamic and static maintenance of epigenetic memory in pluripotent and somatic cells. Nature 513(7516):115-19
    • (2014) Nature , vol.513 , Issue.7516 , pp. 115-119
    • Shipony, Z.1    Mukamel, Z.2    Cohen, N.M.3    Landan, G.4    Chomsky, E.5
  • 154
    • 84904460344 scopus 로고    scopus 로고
    • Dynamic heterogeneity andDNAmethylation in embryonic stem cells
    • Singer ZS,Yong J,Tischler J,Hackett JA, AltinokA, et al. 2014. Dynamic heterogeneity andDNAmethylation in embryonic stem cells. Mol. Cell 55(2):319-31
    • (2014) Mol. Cell , vol.55 , Issue.2 , pp. 319-331
    • Singer, Z.S.1    Yong, J.2    Tischler, J.3    Hackett, J.A.4    Altinok, A.5
  • 155
    • 84890984246 scopus 로고    scopus 로고
    • Cell-cycle control of developmentally regulated transcription factors accounts for heterogeneity in human pluripotent cells
    • Singh AM, Chappell J, Trost R, Lin L, Wang T, et al. 2013. Cell-cycle control of developmentally regulated transcription factors accounts for heterogeneity in human pluripotent cells. Stem Cell Rep. 1(6):532-44
    • (2013) Stem Cell Rep , vol.1 , Issue.6 , pp. 532-544
    • Singh, A.M.1    Chappell, J.2    Trost, R.3    Lin, L.4    Wang, T.5
  • 156
    • 35348816062 scopus 로고    scopus 로고
    • A heterogeneous expression pattern for Nanog in embryonic stem cells
    • Singh AM, Hamazaki T, Hankowski KE, Terada N. 2007. A heterogeneous expression pattern for Nanog in embryonic stem cells. Stem Cells 25(10):2534-42
    • (2007) Stem Cells , vol.25 , Issue.10 , pp. 2534-2542
    • Singh, A.M.1    Hamazaki, T.2    Hankowski, K.E.3    Terada, N.4
  • 157
    • 40949130398 scopus 로고    scopus 로고
    • MicroRNAs control de novo DNA methylation through regulation of transcriptional repressors in mouse embryonic stem cells
    • Sinkkonen L, Hugenschmidt T, Berninger P, Gaidatzis D, Mohn F, et al. 2008. MicroRNAs control de novo DNA methylation through regulation of transcriptional repressors in mouse embryonic stem cells. Nat. Struct. Mol. Biol. 15(3):259-67
    • (2008) Nat. Struct. Mol. Biol , vol.15 , Issue.3 , pp. 259-267
    • Sinkkonen, L.1    Hugenschmidt, T.2    Berninger, P.3    Gaidatzis, D.4    Mohn, F.5
  • 158
    • 84893023300 scopus 로고    scopus 로고
    • Nanog heterogeneity: Tilting at windmills
    • Smith A. 2013. Nanog heterogeneity: tilting at windmills? Cell Stem Cell 13(1):6-7
    • (2013) Cell Stem Cell , vol.13 , Issue.1 , pp. 6-7
    • Smith, A.1
  • 159
    • 84874194072 scopus 로고    scopus 로고
    • DNAmethylation: Roles inmammalian development
    • Smith ZD, Meissner A. 2013.DNAmethylation: roles inmammalian development. Nat. Rev. Genet. 14(3):204-20
    • (2013) Nat. Rev. Genet , vol.14 , Issue.3 , pp. 204-220
    • Smith, Z.D.1    Meissner, A.2
  • 160
    • 78951470515 scopus 로고    scopus 로고
    • Origins of regulated cell-to-cell variability
    • Snijder B, Pelkmans L. 2011. Origins of regulated cell-to-cell variability. Nat. Rev. Mol. Cell Biol. 12(2):119-25
    • (2011) Nat. Rev. Mol. Cell Biol , vol.12 , Issue.2 , pp. 119-125
    • Snijder, B.1    Pelkmans, L.2
  • 161
    • 70349466529 scopus 로고    scopus 로고
    • Population context determines cell-to-cell variability in endocytosis and virus infection
    • Snijder B, Sacher R, Ramo P, Damm E-M, Liberali P, Pelkmans L. 2009. Population context determines cell-to-cell variability in endocytosis and virus infection. Nature 461(7263):520-23
    • (2009) Nature , vol.461 , Issue.7263 , pp. 520-523
    • Snijder, B.1    Sacher, R.2    Ramo, P.3    Damm, E.-M.4    Liberali, P.5    Pelkmans, L.6
  • 162
    • 79551686425 scopus 로고    scopus 로고
    • Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro
    • Spence JR, Mayhew CN, Rankin SA, Kuhar MF, Vallance JE, et al. 2011. Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro. Nature 470(7332):105-9
    • (2011) Nature , vol.470 , Issue.7332 , pp. 105-109
    • Spence, J.R.1    Mayhew, C.N.2    Rankin, S.A.3    Kuhar, M.F.4    Vallance, J.E.5
  • 163
    • 77950358156 scopus 로고    scopus 로고
    • Retinoic acid orchestrates fibroblast growth factor signalling to drive embryonic stem cell differentiation
    • Stavridis MP, Collins BJ, Storey KG. 2010. Retinoic acid orchestrates fibroblast growth factor signalling to drive embryonic stem cell differentiation. Development 137(6):881-90
    • (2010) Development , vol.137 , Issue.6 , pp. 881-890
    • Stavridis, M.P.1    Collins, B.J.2    Storey, K.G.3
  • 164
    • 84857437687 scopus 로고    scopus 로고
    • Cellular noise regulons underlie fluctuations in Saccharomyces cerevisiae
    • Stewart-Ornstein J, Weissman JS, El-Samad H. 2012. Cellular noise regulons underlie fluctuations in Saccharomyces cerevisiae. Mol. Cell 45(4):483-93
    • (2012) Mol. Cell , vol.45 , Issue.4 , pp. 483-493
    • Stewart-Ornstein, J.1    Weissman, J.S.2    El-Samad, H.3
  • 165
    • 77956202054 scopus 로고    scopus 로고
    • Polycomb group proteins set the stage for early lineage commitment
    • Surface LE, Thornton SR, Boyer LA. 2010. Polycomb group proteins set the stage for early lineage commitment. Cell Stem Cell 7(3):288-98
    • (2010) Cell Stem Cell , vol.7 , Issue.3 , pp. 288-298
    • Surface, L.E.1    Thornton, S.R.2    Boyer, L.A.3
  • 166
    • 80455131192 scopus 로고    scopus 로고
    • Oscillatory protein expression dynamics endows stem cells with robust differentiation potential
    • Suzuki N, Furusawa C, Kaneko K. 2011. Oscillatory protein expression dynamics endows stem cells with robust differentiation potential. PLOS ONE 6(11):e27232
    • (2011) PLOS ONE , vol.6 , Issue.11 , pp. e27232
    • Suzuki, N.1    Furusawa, C.2    Kaneko, K.3
  • 167
    • 84871703021 scopus 로고    scopus 로고
    • Bioprinting for stem cell research
    • Tasoglu S, Demirci U. 2013. Bioprinting for stem cell research. Trends Biotechnol. 31(1):10-19
    • (2013) Trends Biotechnol , vol.31 , Issue.1 , pp. 10-19
    • Tasoglu, S.1    Demirci, U.2
  • 168
    • 54949102409 scopus 로고    scopus 로고
    • Wnt signaling mediates self-organization and axis formation in embryoid bodies
    • ten Berge D, KooleW, Fuerer C, FishM, Eroglu E,Nusse R. 2008. Wnt signaling mediates self-organization and axis formation in embryoid bodies. Cell Stem Cell 3(5):508-18
    • (2008) Cell Stem Cell , vol.3 , Issue.5 , pp. 508-518
    • Berge, D.1    Koole, W.2    Fuerer, C.3    Fish, M.4    Eroglu, E.5    Nusse, R.6
  • 169
    • 80052475509 scopus 로고    scopus 로고
    • Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells
    • ten Berge D, Kurek D, Blauwkamp T, Koole W, Maas A, et al. 2011. Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells. Nat. Cell Biol. 13(9):1070-75
    • (2011) Nat. Cell Biol , vol.13 , Issue.9 , pp. 1070-1075
    • Berge, D.1    Kurek, D.2    Blauwkamp, T.3    Koole, W.4    Maas, A.5
  • 170
    • 34447528757 scopus 로고    scopus 로고
    • New cell lines from mouse epiblast share defining features with human embryonic stem cells
    • Tesar PJ, Chenoweth JG, Brook FA, Davies TJ, Evans EP, et al. 2007. New cell lines from mouse epiblast share defining features with human embryonic stem cells. Nature 448(7150):196-99
    • (2007) Nature , vol.448 , Issue.7150 , pp. 196-199
    • Tesar, P.J.1    Chenoweth, J.G.2    Brook, F.A.3    Davies, T.J.4    Evans, E.P.5
  • 171
    • 84922637623 scopus 로고    scopus 로고
    • Systematic identification of culture conditions for induction and maintenance of naive human pluripotency
    • Theunissen TW, Powell BE, Wang H, Mitalipova M, Faddah DA, et al. 2014. Systematic identification of culture conditions for induction and maintenance of naive human pluripotency. Cell Stem Cell 15(4):471-87
    • (2014) Cell Stem Cell , vol.15 , Issue.4 , pp. 471-487
    • Theunissen, T.W.1    Powell, B.E.2    Wang, H.3    Mitalipova, M.4    Faddah, D.A.5
  • 172
    • 79958263080 scopus 로고    scopus 로고
    • Pluripotency factors in embryonic stem cells regulate differentiation into germ layers
    • ThomsonM, Liu SJ, Zou L-N, Smith Z,Meissner A, Ramanathan S. 2011. Pluripotency factors in embryonic stem cells regulate differentiation into germ layers. Cell 145(6):875-89
    • (2011) Cell , vol.145 , Issue.6 , pp. 875-889
    • Thomson, M.1    Liu, S.J.2    Zou, L.-N.3    Smith, Z.4    Meissner, A.5    Ramanathan, S.6
  • 173
    • 77649220197 scopus 로고    scopus 로고
    • Noise can induce bimodality in positive transcriptional feedback loops without bistability
    • To TL, Maheshri N. 2010. Noise can induce bimodality in positive transcriptional feedback loops without bistability. Science 327(5969):1142-45
    • (2010) Science , vol.327 , Issue.5969 , pp. 1142-1145
    • To, T.L.1    Maheshri, N.2
  • 174
    • 84901473732 scopus 로고    scopus 로고
    • Transcription factor heterogeneity in pluripotent stem cells: A stochastic advantage
    • Torres-Padilla M-E, Chambers I. 2014. Transcription factor heterogeneity in pluripotent stem cells: a stochastic advantage. Development 141(11):2173-81
    • (2014) Development , vol.141 , Issue.11 , pp. 2173-2181
    • Torres-Padilla, M.-E.1    Chambers, I.2
  • 175
    • 42149192008 scopus 로고    scopus 로고
    • Identification and characterization of subpopulations in undifferentiated ES cell culture
    • Toyooka Y, Shimosato D, Murakami K, Takahashi K, Niwa H. 2008. Identification and characterization of subpopulations in undifferentiated ES cell culture. Development 135(5):909-18
    • (2008) Development , vol.135 , Issue.5 , pp. 909-918
    • Toyooka, Y.1    Shimosato, D.2    Murakami, K.3    Takahashi, K.4    Niwa, H.5
  • 176
    • 84900873950 scopus 로고    scopus 로고
    • The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells
    • Trapnell C, Cacchiarelli D, Grimsby J, Pokharel P, Li S, et al. 2014. The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells. Nat. Biotechnol. 32(4):381-86
    • (2014) Nat. Biotechnol , vol.32 , Issue.4 , pp. 381-386
    • Trapnell, C.1    Cacchiarelli, D.2    Grimsby, J.3    Pokharel, P.4    Li, S.5
  • 177
    • 84900529199 scopus 로고    scopus 로고
    • Reconstructing lineage hierarchies of the distal lung epithelium using single-cell RNA-seq
    • Treutlein B, Brownfield DG, Wu AR, Neff NF, Mantalas GL, et al. 2014. Reconstructing lineage hierarchies of the distal lung epithelium using single-cell RNA-seq. Nature 509(7500):371-75
    • (2014) Nature , vol.509 , Issue.7500 , pp. 371-375
    • Treutlein, B.1    Brownfield, D.G.2    Wu, A.R.3    Neff, N.F.4    Mantalas, G.L.5
  • 178
    • 84979502917 scopus 로고    scopus 로고
    • Single cell lineage analysis of mouse embryonic stem cells at the exit from pluripotency
    • Trott J, Martinez Arias A. 2013. Single cell lineage analysis of mouse embryonic stem cells at the exit from pluripotency. Biol. Open 2(10):1049-56
    • (2013) Biol. Open , vol.2 , Issue.10 , pp. 1049-1056
    • Trott, J.1    Martinez, A.A.2
  • 179
    • 77950348609 scopus 로고    scopus 로고
    • Genome-wide dissection of microRNA functions and cotargeting networks using gene set signatures
    • Tsang JS, Ebert MS, van Oudenaarden A. 2010. Genome-wide dissection of microRNA functions and cotargeting networks using gene set signatures. Mol. Cell 38(1):140-53
    • (2010) Mol. Cell , vol.38 , Issue.1 , pp. 140-153
    • Tsang, J.S.1    Ebert, M.S.2    Van Oudenaarden, A.3
  • 180
    • 84923366467 scopus 로고    scopus 로고
    • Transcription factor binding dynamics during human ES cell differentiation
    • Tsankov AM, Gu H, Akopian V, Ziller MJ, Donaghey J, et al. 2015. Transcription factor binding dynamics during human ES cell differentiation. Nature 518(7539):344-49
    • (2015) Nature , vol.518 , Issue.7539 , pp. 344-349
    • Tsankov, A.M.1    Gu, H.2    Akopian, V.3    Ziller, M.J.4    Donaghey, J.5
  • 181
    • 84908457386 scopus 로고    scopus 로고
    • An interplay between extracellular signalling and the dynamics of the exit from pluripotency drives cell fate decisions in mouse ES cells
    • Turner DA, Trott J, Hayward P, Rue P,Martinez Arias A. 2014. An interplay between extracellular signalling and the dynamics of the exit from pluripotency drives cell fate decisions in mouse ES cells. Biol. Open 3(7):614-26
    • (2014) Biol. Open , vol.3 , Issue.7 , pp. 614-626
    • Turner, D.A.1    Trott, J.2    Hayward, P.3    Rue, P.4    Martinez, A.A.5
  • 182
    • 67650567329 scopus 로고    scopus 로고
    • Early cell fate decisions of human embryonic stem cells and mouse epiblast stem cells are controlled by the same signalling pathways
    • Vallier L, Touboul T, Chng Z, Brimpari M, Hannan N, et al. 2009. Early cell fate decisions of human embryonic stem cells and mouse epiblast stem cells are controlled by the same signalling pathways. PLOS ONE 4(6):e6082
    • (2009) PLOS ONE , vol.4 , Issue.6 , pp. e6082
    • Vallier, L.1    Touboul, T.2    Chng, Z.3    Brimpari, M.4    Hannan, N.5
  • 183
    • 84908453706 scopus 로고    scopus 로고
    • Symmetry breaking, germ layer specification and axial organisation in aggregates of mouse embryonic stem cells
    • van den Brink SC, Baillie-Johnson P, Balayo T, Hadjantonakis A-K, Nowotschin S, et al. 2014. Symmetry breaking, germ layer specification and axial organisation in aggregates of mouse embryonic stem cells. Development 141(22):4231-42
    • (2014) Development , vol.141 , Issue.22 , pp. 4231-4242
    • Van Den Brink, S.C.1    Baillie-Johnson, P.2    Balayo, T.3    Hadjantonakis, A.-K.4    Nowotschin, S.5
  • 185
    • 84922115236 scopus 로고    scopus 로고
    • Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells
    • Wang J, XieG, Singh M, Ghanbarian AT,Rask oT, et al. 2014. Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells. Nature 516(7531):405-9
    • (2014) Nature , vol.516 , Issue.7531 , pp. 405-409
    • Wang, J.1    Xie, G.2    Singh, M.3    Ghanbarian, A.T.4    Rask, O. T.5
  • 186
    • 77952914558 scopus 로고    scopus 로고
    • The potential landscape of genetic circuits imposes the arrow of time in stem cell differentiation
    • Wang J, Xu L, Wang E, Huang S. 2010. The potential landscape of genetic circuits imposes the arrow of time in stem cell differentiation. Biophys. J. 99(1):29-39
    • (2010) Biophys. J , vol.99 , Issue.1 , pp. 29-39
    • Wang, J.1    Xu, L.2    Wang, E.3    Huang, S.4
  • 187
    • 33847323881 scopus 로고    scopus 로고
    • DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal
    • Wang Y, Medvid R, Melton C, Jaenisch R, Blelloch R. 2007. DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal. Nat. Genet. 39(3):380-85
    • (2007) Nat. Genet , vol.39 , Issue.3 , pp. 380-385
    • Wang, Y.1    Medvid, R.2    Melton, C.3    Jaenisch, R.4    Blelloch, R.5
  • 188
    • 84859539293 scopus 로고    scopus 로고
    • Distinct lineage specification roles for NANOG, OCT4, and SOX2 in human embryonic stem cells
    • Wang Z, Oron E, Nelson B, Razis S, Ivanova N. 2012. Distinct lineage specification roles for NANOG, OCT4, and SOX2 in human embryonic stem cells. Cell Stem Cell 10(4):440-54
    • (2012) Cell Stem Cell , vol.10 , Issue.4 , pp. 440-454
    • Wang, Z.1    Oron, E.2    Nelson, B.3    Razis, S.4    Ivanova, N.5
  • 189
    • 84896912846 scopus 로고    scopus 로고
    • Derivation of naive human embryonic stem cells
    • Ware CB, Nelson AM, Mecham B, Hesson J, Zhou W, et al. 2014. Derivation of naive human embryonic stem cells. PNAS 111(12):4484-89
    • (2014) PNAS , vol.111 , Issue.12 , pp. 4484-4489
    • Ware, C.B.1    Nelson, A.M.2    Mecham, B.3    Hesson, J.4    Zhou, W.5
  • 190
    • 84905258655 scopus 로고    scopus 로고
    • A method to recapitulate early embryonic spatial patterning in human embryonic stem cells
    • Warmflash A, Sorre B, Etoc F, Siggia ED, Brivanlou AH. 2014. A method to recapitulate early embryonic spatial patterning in human embryonic stem cells. Nat. Methods 11(8):847-54
    • (2014) Nat. Methods , vol.11 , Issue.8 , pp. 847-854
    • Warmflash, A.1    Sorre, B.2    Etoc, F.3    Siggia, E.D.4    Brivanlou, A.H.5
  • 191
    • 77958536106 scopus 로고    scopus 로고
    • Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA
    • Warren L,Manos PD, Ahfeldt T, Loh Y-H, Li H, et al. 2010. Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell 7(5):618-30
    • (2010) Cell Stem Cell , vol.7 , Issue.5 , pp. 618-630
    • Warren, L.1    Manos, P.D.2    Ahfeldt, T.3    Loh, Y.-H.4    Li, H.5
  • 192
    • 0035985177 scopus 로고    scopus 로고
    • Identification of genes periodically expressed in the human cell cycle and their expression in tumors
    • Whitfield ML, Sherlock G, Saldanha AJ, Murray JI, Ball CA, et al. 2002. Identification of genes periodically expressed in the human cell cycle and their expression in tumors. Mol. Biol. Cell 13(6):1977-2000
    • (2002) Mol. Biol. Cell , vol.13 , Issue.6 , pp. 1977-2000
    • Whitfield, M.L.1    Sherlock, G.2    Saldanha, A.J.3    Murray, J.I.4    Ball, C.A.5
  • 193
    • 84876216563 scopus 로고    scopus 로고
    • Master transcription factors and mediator establish super-enhancers at key cell identity genes
    • WhyteWA,Orlando DA, HniszD,Abraham BJ,Lin CY, et al. 2013. Master transcription factors and mediator establish super-enhancers at key cell identity genes. Cell 153(2):307-19
    • (2013) Cell , vol.153 , Issue.2 , pp. 307-319
    • Whyte, W.A.1    Orlando, D.A.2    Hnisz, D.3    Abraham, B.J.4    Lin, C.Y.5
  • 194
    • 84864353543 scopus 로고    scopus 로고
    • SnapShot: Directed differentiation of pluripotent stem cells
    • Williams LA, Davis-Dusenbery BN, Eggan KC. 2012. SnapShot: directed differentiation of pluripotent stem cells. Cell 149(5):1174
    • (2012) Cell , vol.149 , Issue.5 , pp. 1174
    • Williams, L.A.1    Davis-Dusenbery, B.N.2    Eggan, K.C.3
  • 195
  • 196
    • 84893910301 scopus 로고    scopus 로고
    • Quantitative assessment of single-cell RNA-sequencing methods
    • Wu AR, Neff NF, Kalisky T, Dalerba P, Treutlein B, et al. 2014. Quantitative assessment of single-cell RNA-sequencing methods. Nat. Methods 11(1):41-46
    • (2014) Nat. Methods , vol.11 , Issue.1 , pp. 41-46
    • Wu, A.R.1    Neff, N.F.2    Kalisky, T.3    Dalerba, P.4    Treutlein, B.5
  • 197
    • 84878282421 scopus 로고    scopus 로고
    • Epigenomic analysis of multilineage differentiation of human embryonic stem cells
    • Xie W, Schultz MD, Lister R, Hou Z, Rajagopal N, et al. 2013. Epigenomic analysis of multilineage differentiation of human embryonic stem cells. Cell 153(5):1134-48
    • (2013) Cell , vol.153 , Issue.5 , pp. 1134-1148
    • Xie, W.1    Schultz, M.D.2    Lister, R.3    Hou, Z.4    Rajagopal, N.5
  • 198
    • 84903473477 scopus 로고    scopus 로고
    • Otx2 and Oct4 drive early enhancer activation during embryonic stem cell transition from naive pluripotency
    • Yang S-H, Kalkan T, Morissroe C, MarksH, StunnenbergH, et al. 2014. Otx2 and Oct4 drive early enhancer activation during embryonic stem cell transition from naive pluripotency. Cell Rep. 7(6):1968-81
    • (2014) Cell Rep , vol.7 , Issue.6 , pp. 1968-1981
    • Yang, S.-H.1    Kalkan, T.2    Morissroe, C.3    Marks, H.4    Stunnenberg, H.5
  • 199
    • 84872028640 scopus 로고    scopus 로고
    • A genome-wide RNAi screen reveals MAP kinase phosphatases as key ERK pathway regulators during embryonic stem cell differentiation
    • Yang S-H, Kalkan T, Morrisroe C, Smith A, Sharrocks AD. 2012. A genome-wide RNAi screen reveals MAP kinase phosphatases as key ERK pathway regulators during embryonic stem cell differentiation. PLOS Genet. 8(12):e1003112
    • (2012) PLOS Genet , vol.8 , Issue.12 , pp. e1003112
    • Yang, S.-H.1    Kalkan, T.2    Morrisroe, C.3    Smith, A.4    Sharrocks, A.D.5
  • 200
    • 84906491957 scopus 로고    scopus 로고
    • Signaling pathways in induced naïve pluripotency
    • Ye S, Liu D, Ying Q-L. 2014. Signaling pathways in induced naïve pluripotency. Curr. Opin. Genet. Dev. 28:10-15
    • (2014) Curr. Opin. Genet. Dev , vol.28 , pp. 10-15
    • Ye, S.1    Liu, D.2    Ying, Q.-L.3
  • 201
    • 44349170450 scopus 로고    scopus 로고
    • The ground state of embryonic stem cell self-renewal
    • Ying Q-L, Wray J, Nichols J, Batlle-Morera L, Doble B, et al. 2008. The ground state of embryonic stem cell self-renewal. Nature 453(7194):519-23
    • (2008) Nature , vol.453 , Issue.7194 , pp. 519-523
    • Ying, Q.-L.1    Wray, J.2    Nichols, J.3    Batlle-Morera, L.4    Doble, B.5
  • 202
    • 79952660821 scopus 로고    scopus 로고
    • Control of the embryonic stem cell state
    • Young RA. 2011. Control of the embryonic stem cell state. Cell 144(6):940-54
    • (2011) Cell , vol.144 , Issue.6 , pp. 940-954
    • Young, R.A.1
  • 203
    • 80455144479 scopus 로고    scopus 로고
    • Pioneer transcription factors: Establishing competence for gene expression
    • Zaret KS, Carroll JS. 2011. Pioneer transcription factors: establishing competence for gene expression. Genes Dev. 25(21):2227-41
    • (2011) Genes Dev , vol.25 , Issue.21 , pp. 2227-2241
    • Zaret, K.S.1    Carroll, J.S.2
  • 204
    • 84904316003 scopus 로고    scopus 로고
    • Stem cell differentiation as a many-body problem
    • Zhang B,Wolynes PG. 2014. Stem cell differentiation as a many-body problem. PNAS 111(28):10185-90
    • (2014) PNAS , vol.111 , Issue.28 , pp. 10185-10190
    • Zhang, B.1    Wolynes, P.G.2
  • 205
    • 84923382398 scopus 로고    scopus 로고
    • Dissecting neural differentiation regulatory networks through epigenetic footprinting
    • ZillerMJ, EdriR,Yaffe Y, Donaghey J, PopR, et al. 2015. Dissecting neural differentiation regulatory networks through epigenetic footprinting. Nature 518(7539):355-59
    • (2015) Nature , vol.518 , Issue.7539 , pp. 355-359
    • Ziller, M.J.1    Edri, R.2    Yaffe, Y.3    Donaghey, J.4    Pop, R.5
  • 206
    • 84880815428 scopus 로고    scopus 로고
    • Cell-cycle dependence of transcription dominates noise in gene expression
    • Zopf CJ, Quinn K, Zeidman J,Maheshri N. 2013. Cell-cycle dependence of transcription dominates noise in gene expression. PLOS Comput. Biol. 9(7):e1003161
    • (2013) PLOS Comput. Biol , vol.9 , Issue.7 , pp. e1003161
    • Zopf, C.J.1    Quinn, K.2    Zeidman, J.3    Maheshri, N.4


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