Early cell fate decisions of human embryonic stem cells and mouse epiblast stem cells are controlled by the same signalling pathways

PLoS ONE

Volumn 4, Issue 6, 2009, Pages

  Vallier, Ludovic ^a   Touboul, Thomas ^a,b   Chng, Zhenzhi ^a   Brimpari, Minodora ^a   Hannan, Nicholas ^a   Millan, Enrique ^a,e   Smithers, Lucy E ^c,f   Trotter, Matthew ^a   Rugg Gunn, Peter ^d   Weber, Anne ^b   Pedersen, Roger A ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b INSERM   (France)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d HOSPITAL FOR SICK CHILDREN   (Canada)

^e Department of Cell Centric ^*  (United Kingdom)

^f KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 4; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 2; GROWTH FACTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN NODAL; WNT PROTEIN; BMP4 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL FATE; CELL MATURATION; CELL TYPE; CONTROLLED STUDY; CULTURE MEDIUM; ECTODERM; EMBRYO; EMBRYO DEVELOPMENT; EMBRYONAL TISSUE; EMBRYONIC STEM CELL; ENDODERM; EPIBLAST STEM CELL; HUMAN; HUMAN CELL; MESODERM; NEUROECTODERM; NONHUMAN; PLURIPOTENT STEM CELL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; STEM CELL; ANIMAL; BIOLOGICAL MODEL; CELL LINEAGE; CYTOLOGY; GERM LAYER; METABOLISM; MOUSE; PHYSIOLOGY;

MAMMALIA;

ANIMALS; BONE MORPHOGENETIC PROTEIN 4; CELL DIFFERENTIATION; CELL LINEAGE; ECTODERM; EMBRYONIC STEM CELLS; ENDODERM; GERM LAYERS; HUMANS; MESODERM; MICE; MODELS, BIOLOGICAL; SIGNAL TRANSDUCTION; STEM CELLS;

EID: 67650567329     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0006082     Document Type: Article

References (37)

1. Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, et al. (1998) Embryonic stem cell lines derived from human blastocysts. Science 282: 1145-1147.
2. D'Amour KA, Agulnick AD, Eliazer S, Kelly OG, Kroon E, et al. (2005) Efficient differentiation of human embryonic stem cells to definitive endoderm. Nat Biotechnol 23: 1534-1541.
3. D'Amour KA, Bang AG, Eliazer S, Kelly OG, Agulnick AD, et al. (2006) Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat Biotechnol 24: 1392-1401.
4. Brons IG, Smithers LE, Trotter MW, Rugg-Gunn P, Sun B, et al. (2007) Derivation of pluripotent epiblast stem cells from mammalian embryos. Nature 448: 191-195.
5. Tesar PJ, Chenoweth JG, Brook FA, Davies TJ, Evans EP, et al. (2007) New cell lines from mouse epiblast share defining features with human embryonic stem cells. Nature 448: 196-199.
6. Tam PP, Kanai-Azuma M, Kanai Y (2003) Early endoderm development in vertebrates: lineage differentiation and morphogenetic function. Curr Opin Genet Dev 13: 393-400.
7. Schier AF, Talbot WS (2005) Molecular genetics of axis formation in zebrafish. Annu Rev Genet 39: 561-613.
8. Robb L, Tam PP (2004) Gastrula organiser and embryonic patterning in the mouse. Semin Cell Dev Biol 15: 543-554.
9. Johansson BM, Wiles MV (1995) Evidence for involvement of activin A and bone morphogenetic protein 4 in mammalian mesoderm and hematopoietic development. Mol Cell Biol 15: 141-151.
10. Inman GJ, Nicolas FJ, Callahan JF, Harling JD, Gaster LM, et al. (2002) SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Mol Pharmacol 62: 65-74.
11. Mohammadi M, McMahon G, Sun L, Tang C, Hirth P, et al. (1997) Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors. Science 276: 955-960.
12. McLean AB, D'Amour KA, Jones KL, Krishnamoorthy M, Kulik MJ, et al. (2007) Activin a efficiently specifies definitive endoderm from human embryonic stem cells only when phosphatidylinositol 3-kinase signaling is suppressed. Stem Cells 25: 29-38.
13. Brons IGM, Smithers LE, Trotter MWB, Rugg-Gun P, Sun B, Chuva de Sousa Lopes SM, Howlett SK, Clarkson A, Ahrlund-Richter L, Pedersen RA, Vallier L (2007) Derivation of pluripotent Epiblast Stem Cells form mammalian embryos. Nature, in Press.
14. Ying QL, Nichols J, Chambers I, Smith A (2003) BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3. Cell 115: 281-292.
15. Xu RH, Chen X, Li DS, Li R, Addicks GC, et al. (2002) BMP4 initiates human embryonic stem cell differentiation to trophoblast. Nat Biotechnol 20: 1261-1264.
16. Smith JR, Vallier L, Lupo G, Alexander M, Harris WA, et al. (2008) Inhibition of Activin/Nodal signaling promotes specification of human embryonic stem cells into neuroectoderm. Dev Biol 313: 107-117.
17. Sato N, Meijer L, Skaltsounis L, Greengard P, Brivanlou AH (2004) Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nat Med 10: 55-63.
18. Yasunaga M, Tada S, Torikai-Nishikawa S, Nakano Y, Okada M, et al. (2005) Induction and monitoring of definitive and visceral endoderm differentiation of mouse ES cells. Nat Biotechnol 23: 1542-1550.
19. Tada S, Era T, Furusawa C, Sakurai H, Nishikawa S, et al. (2005) Characterization of mesendoderm: a diverging point of the definitive endoderm and mesoderm in embryonic stem cell differentiation culture. Development 132: 4363-4374.
20. Kubo A, Shinozaki K, Shannon JM, Kouskoff V, Kennedy M, et al. (2004) Development of definitive endoderm from embryonic stem cells in culture. Development 131: 1651-1662.
21. Camus A, Perea-Gomez A, Moreau A, Collignon J (2006) Absence of Nodal signaling promotes precocious neural differentiation in the mouse embryo. Dev Biol 295: 743-755.
22. Takaoka K, Yamamoto M, Shiratori H, Meno C, Rossant J, et al. (2006) The mouse embryo autonomously acquires anterior-posterior polarity at implantation. Dev Cell 10: 451-459.
23. Stern CD (2005) Neural induction: old problem, new findings, yet more questions. Development 132: 2007-2021.
24. Kunath T, Saba-El-Leil MK, Almousailleakh M, Wray J, Meloche S, et al. (2007) FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment. Development 134: 2895-2902.
25. Vallier L, Reynolds D, Pedersen RA (2004) Nodal inhibits differentiation of human embryonic stem cells along the neuroectodermal default pathway. Dev Biol 275: 403-421.
26. Mesnard D, Guzman-Ayala M, Constam DB (2006) Nodal specifies embryonic visceral endoderm and sustains pluripotent cells in the epiblast before overt axial patterning. Development 133: 2497-2505.
27. Chang C, Harland RM (2007) Neural induction requires continued suppression of both Smad1 and Smad2 signals during gastrulation. Development 134: 3861-3872.
28. Bachiller D, Klingensmith J, Kemp C, Belo JA, Anderson RM, et al. (2000) The organizer factors Chordin and Noggin are required for mouse forebrain development. Nature 403: 658-661.
29. Munoz-Sanjuan I, Brivanlou AH (2002) Neural induction, the default model and embryonic stem cells. Nat Rev Neurosci 3: 271-280.
30. Mishina Y, Suzuki A, Ueno N, Behringer RR (1995) Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis. Genes Dev 9: 3027-3037.
31. Winnier G, Blessing M, Labosky PA, Hogan BL (1995) Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. Genes Dev 9: 2105-2116.
32. Gu Z, Reynolds EM, Song J, Lei H, Feijen A, et al. (1999) The type I serine/threonine kinase receptor ActRIA (ALK2) is required for gastrulation of the mouse embryo. Development 126: 2551-2561.
33. Di-Gregorio A, Sancho M, Stuckey DW, Crompton LA, Godwin J, et al. (2007) BMP signalling inhibits premature neural differentiation in the mouse embryo. Development 134: 3359-3369.
34. de Sousa Lopes SM, Roelen BA, Monteiro RM, Emmens R, Lin HY, et al. (2004) BMP signaling mediated by ALK2 in the visceral endoderm is necessary for the generation of primordial germ cells in the mouse embryo. Genes Dev 18: 1838-1849.
35. Irizarry RA, Bolstad BM, Collin F, Cope LM, Hobbs B, et al. (2003) Summaries of Affymetrix GeneChip probe level data. Nucleic Acids Res 31: e15.
36. Smyth GK (2004) Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 3: Article3.
37. Storey JD, Tibshirani R (2003) Statistical significance for genomewide studies. Proc Natl Acad Sci U S A 100: 9440-9445.