FGF signaling inhibition in ESCs drives rapid genome-wide demethylation to the epigenetic ground state of pluripotency

Cell Stem Cell

Volumn 13, Issue 3, 2013, Pages 351-359

  Ficz, Gabriella ^a   Hore, Timothy A ^a   Santos, Fátima ^a   Lee, Heather J ^a   Dean, Wendy ^a   Arand, Julia ^b   Krueger, Felix ^a   Oxley, David ^a   Paul, Yu Lee ^a   Walter, Jörn ^b   Cook, Simon J ^a   Andrews, Simon ^a   Branco, Miguel R ^a,c   Reik, Wolf ^a,c,d  

^a BABRAHAM INSTITUTE   (United Kingdom)

^b SAARLAND UNIVERSITY   (Germany)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

5 HYDROXYMETHYLCYTOSINE; 5 METHYLCYTOSINE; DNA METHYLTRANSFERASE 3A; DNA METHYLTRANSFERASE 3B; FIBROBLAST GROWTH FACTOR; INTRACISTERNAL A PARTICLE; MITOGEN ACTIVATED PROTEIN KINASE 3; SMALL MOLECULE TRANSPORT AGENT; SODIUM METABISULFITE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL MIGRATION; COMPUTER PROGRAM; CONTROLLED STUDY; DEMETHYLATION; DNA METHYLATION; DNA SEQUENCE; EMBRYO; EMBRYO CELL; ENZYME INHIBITION; EPIGENETICS; GENE REPRESSION; GENETIC ASSOCIATION; GENOME IMPRINTING; INTRACISTERNAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATION KINETICS; PLURIPOTENT STEM CELL; PRIMORDIAL GERM CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

INTRACISTERNAL A-PARTICLES;

ANIMALS; CELL LINE; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; DNA-BINDING PROTEINS; EMBRYONIC STEM CELLS; EPIGENETIC REPRESSION; EPIGENOMICS; FIBROBLAST GROWTH FACTORS; GENOME; GERM CELLS; HOMEODOMAIN PROTEINS; MAP KINASE SIGNALING SYSTEM; MICE; PLURIPOTENT STEM CELLS; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS; REGULATORY SEQUENCES, NUCLEIC ACID; TRANSCRIPTION FACTORS;

EID: 84884164554     PISSN: 19345909     EISSN: 18759777     Source Type: Journal    
DOI: 10.1016/j.stem.2013.06.004     Document Type: Article

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