Using gene expression noise to understand gene regulation

Science

Volumn 336, Issue 6078, 2012, Pages 183-187

  Munsky, Brian ^a   Neuert, Gregor ^b   Van Oudenaarden, Alexander ^b,c  

^a CENTER FOR NONLINEAR STUDIES   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CYAN FLUORESCENT PROTEIN; MESSENGER RNA; RED FLUORESCENT PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GAL4; YELLOW FLUORESCENT PROTEIN;

GENE EXPRESSION; NOISE; PHENOTYPIC PLASTICITY; PHYSIOLOGY;

CELL VIABILITY; CHROMATIN; COPY NUMBER VARIATION; DAUGHTER CELL; ENVIRONMENTAL EXPOSURE; ESCHERICHIA COLI; FLUORESCENCE IN SITU HYBRIDIZATION; GENE CONTROL; GENE EXPRESSION; GENOTYPE; HOUSEKEEPING GENE; HUMAN; KINETICS; NOISE; NONHUMAN; PHENOTYPIC VARIATION; POISSON DISTRIBUTION; PRIORITY JOURNAL; PROTEIN DEGRADATION; REVIEW;

EID: 84859641038     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1216379     Document Type: Review

References (35)

1. G.-W. Li, X. S. Xie, Nature 475, 308 (2011).
2. A. Raj, A. van Oudenaarden, Cell 135, 216 (2008).
3. G. Balázsi, A. van Oudenaarden, J. J. Collins, Cell 144, 910 (2011).
4. A. Eldar, M. B. Elowitz, Nature 467, 167 (2010).
5. M. E. Lidstrom, M. C. Konopka, Nat. Chem. Biol. 6, 705 (2010).
6. B. Snijder, L. Pelkmans, Nat. Rev. Mol. Cell Biol. 12, 119 (2011).
7. D. Zenklusen, D. R. Larson, R. H. Singer, Nat. Struct. Mol. Biol. 15, 1263 (2008).
8. M. Thattai, A. van Oudenaarden, Proc. Natl. Acad. Sci. U.S.A. 98, 8614 (2001).
9. A. M. Femino, F. S. Fay, K. Fogarty, R. H. Singer, Science 280, 585 (1998).
10. A. Raj, P. van den Bogaard, S. A. Rifkin, A. van Oudenaarden, S. Tyagi, Nat. Methods 5, 877 (2008).
11. I. Golding, J. Paulsson, S. M. Zawilski, E. C. Cox, Cell 123, 1025 (2005).
12. J. Peccoud, B. Ycart, Theor. Popul. Biol. 48, 222 (1995).
13. T. B. Kepler, T. C. Elston, Biophys. J. 81, 3116 (2001).
14. J. M. Raser, E. K. O'Shea, Science 304, 1811 (2004).
15. A. Raj, C. S. Peskin, D. Tranchina, D. Y. Vargas, S. Tyagi, PLoS Biol. 4, e309 (2006).
16. V. Shahrezaei, P. S. Swain, Proc. Natl. Acad. Sci. U.S.A. 105, 17256 (2008).
17. S. Iyer-Biswas, F. Hayot, C. Jayaprakash, Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 79, 031911 (2009).
18. S. J. Gandhi, D. Zenklusen, T. Lionnet, R. H. Singer, Nat. Struct. Mol. Biol. 18, 27 (2011).
19. L.-H. So et al., Nat. Genet. 43, 554 (2011).
20. R. Z. Tan, A. van Oudenaarden, Mol. Syst. Biol. 6, 358 (2010).
21. S. L. Bumgarner et al., Mol. Cell 45, 470 (2012).
22. L. M. Octavio, K. Gedeon, N. Maheshri, PLoS Genet. 5, e1000673 (2009).
23. J. M. Pedraza, A. van Oudenaarden, Science 307, 1965 (2005).
24. N. Rosenfeld, J. W. Young, U. Alon, P. S. Swain, M. B. Elowitz, Science 307, 1962 (2005).
25. J. Stewart-Ornstein, J. S. Weissman, H. El-Samad, Mol. Cell 45, 483 (2012).
26. M. J. Dunlop, R. S. Cox III, J. H. Levine, R. M. Murray, M. B. Elowitz, Nat. Genet. 40, 1493 (2008).
27. Y. Taniguchi et al., Science 329, 533 (2010).
28. B. Huang, M. Bates, X. Zhuang, Annu. Rev. Biochem. 78, 993 (2009).
29. L. Bonetta, Nat. Methods 2, 785 (2005).
30. T. Kalisky, P. Blainey, S. R. Quake, Annu. Rev. Genet. 45, 431 (2011).
31. F. Tang et al., Nat. Methods 6, 377 (2009).
32. S. Itzkovitz et al., Nat. Cell Biol. 14, 106 (2012).
33. P. Dalerba et al., Nat. Biotechnol. 29, 1120 (2011).
34. B. Munsky, M. Khammash, J. Chem. Phys. 124, 044104 (2006).
35. D. T. Gillespie, J. Phys. Chem. 81, 2340 (1977).