메뉴 건너뛰기




Volumn 305, Issue 2, 2007, Pages 695-713

Bifurcation dynamics in lineage-commitment in bipotent progenitor cells

Author keywords

Attractor; Auto regulation; Bifurcation; Cell fate commitment; GATA1; Multipotency; Progenitor cell; PU.1; Stochastic regulation

Indexed keywords

MESSENGER RNA; TRANSCRIPTION FACTOR GATA 1; TRANSCRIPTION FACTOR PU 1; TRANSCRIPTOME;

EID: 34248199004     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ydbio.2007.02.036     Document Type: Article
Times cited : (460)

References (76)
  • 2
    • 0034624828 scopus 로고    scopus 로고
    • A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
    • Akashi K., Traver D., Miyamoto T., and Weissman I.L. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature 404 (2000) 193-197
    • (2000) Nature , vol.404 , pp. 193-197
    • Akashi, K.1    Traver, D.2    Miyamoto, T.3    Weissman, I.L.4
  • 3
    • 0037438387 scopus 로고    scopus 로고
    • Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is hierarchically controlled during early hematopoiesis
    • Akashi K., He X., Chen J., Iwasaki H., Niu C., Steenhard B., Zhang J., Haug J., and Li L. Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is hierarchically controlled during early hematopoiesis. Blood 101 (2003) 383-389
    • (2003) Blood , vol.101 , pp. 383-389
    • Akashi, K.1    He, X.2    Chen, J.3    Iwasaki, H.4    Niu, C.5    Steenhard, B.6    Zhang, J.7    Haug, J.8    Li, L.9
  • 4
    • 4243911221 scopus 로고    scopus 로고
    • Epigenetics as a first exit problem
    • Aurell E., and Sneppen K. Epigenetics as a first exit problem. Phys. Rev. Lett. 88 (2002) 048101
    • (2002) Phys. Rev. Lett. , vol.88 , pp. 048101
    • Aurell, E.1    Sneppen, K.2
  • 5
    • 0030574422 scopus 로고    scopus 로고
    • Counting and classifying attractors in high dimensional dynamical systems
    • Bagley R.J., and Glass L. Counting and classifying attractors in high dimensional dynamical systems. J. Theor. Biol. 183 (1996) 269-284
    • (1996) J. Theor. Biol. , vol.183 , pp. 269-284
    • Bagley, R.J.1    Glass, L.2
  • 9
  • 10
    • 0035480007 scopus 로고    scopus 로고
    • Hematopoietic development: a balancing act
    • Cantor A.B., and Orkin S.H. Hematopoietic development: a balancing act. Curr. Opin. Genet. Dev. 11 (2001) 513-519
    • (2001) Curr. Opin. Genet. Dev. , vol.11 , pp. 513-519
    • Cantor, A.B.1    Orkin, S.H.2
  • 11
    • 0037071383 scopus 로고    scopus 로고
    • Transcriptional regulation of erythropoiesis: an affair involving multiple partners
    • Cantor A.B., and Orkin S.H. Transcriptional regulation of erythropoiesis: an affair involving multiple partners. Oncogene 21 (2002) 3368-3376
    • (2002) Oncogene , vol.21 , pp. 3368-3376
    • Cantor, A.B.1    Orkin, S.H.2
  • 12
    • 33645097646 scopus 로고    scopus 로고
    • Multistable and multistep dynamics in neutrophil differentiation
    • Chang H.H., Oh P.Y., Ingber D.E., and Huang S. Multistable and multistep dynamics in neutrophil differentiation. BMC Cell Biol. 7 (2006) 11
    • (2006) BMC Cell Biol. , vol.7 , pp. 11
    • Chang, H.H.1    Oh, P.Y.2    Ingber, D.E.3    Huang, S.4
  • 14
    • 11844273196 scopus 로고    scopus 로고
    • High-dimensional switches and the modelling of cellular differentiation
    • Cinquin O., and Demongeot J. High-dimensional switches and the modelling of cellular differentiation. J. Theor. Biol. 233 (2005) 391-411
    • (2005) J. Theor. Biol. , vol.233 , pp. 391-411
    • Cinquin, O.1    Demongeot, J.2
  • 16
    • 0030838280 scopus 로고    scopus 로고
    • The lineage commitment of haemopoietic progenitor cells
    • Cross M.A., and Enver T. The lineage commitment of haemopoietic progenitor cells. Curr. Opin. Genet. Dev. 7 (1997) 609-613
    • (1997) Curr. Opin. Genet. Dev. , vol.7 , pp. 609-613
    • Cross, M.A.1    Enver, T.2
  • 17
    • 32444446240 scopus 로고    scopus 로고
    • Gene regulatory networks and the evolution of animal body plans
    • Davidson E.H., and Erwin D.H. Gene regulatory networks and the evolution of animal body plans. Science 311 (2006) 796-800
    • (2006) Science , vol.311 , pp. 796-800
    • Davidson, E.H.1    Erwin, D.H.2
  • 19
    • 0344464733 scopus 로고    scopus 로고
    • Gene Expression Dynamics Inspector (GEDI): for integrative analysis of expression profiles
    • Eichler G.S., Huang S., and Ingber D.E. Gene Expression Dynamics Inspector (GEDI): for integrative analysis of expression profiles. Bioinformatics 19 (2003) 2321-2322
    • (2003) Bioinformatics , vol.19 , pp. 2321-2322
    • Eichler, G.S.1    Huang, S.2    Ingber, D.E.3
  • 20
    • 0032527272 scopus 로고    scopus 로고
    • Do stem cells play dice?
    • discussion 352
    • Enver T., Heyworth C.M., and Dexter T.M. Do stem cells play dice?. Blood 92 (1998) 348-351 discussion 352
    • (1998) Blood , vol.92 , pp. 348-351
    • Enver, T.1    Heyworth, C.M.2    Dexter, T.M.3
  • 21
    • 0027261321 scopus 로고
    • Suppression of apoptosis allows differentiation and development of a multipotent hemopoietic cell line in the absence of added growth factors
    • Fairbairn L.J., Cowling G.J., Reipert B.M., and Dexter T.M. Suppression of apoptosis allows differentiation and development of a multipotent hemopoietic cell line in the absence of added growth factors. Cell 74 (1993) 823-832
    • (1993) Cell , vol.74 , pp. 823-832
    • Fairbairn, L.J.1    Cowling, G.J.2    Reipert, B.M.3    Dexter, T.M.4
  • 22
    • 0033001953 scopus 로고    scopus 로고
    • Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes
    • Fambrough D., McClure K., Kazlauskas A., and Lander E.S. Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes. Cell 97 (1999) 727-741
    • (1999) Cell , vol.97 , pp. 727-741
    • Fambrough, D.1    McClure, K.2    Kazlauskas, A.3    Lander, E.S.4
  • 23
    • 13444270650 scopus 로고    scopus 로고
    • GATA1 function, a paradigm for transcription factors in hematopoiesis
    • Ferreira R., Ohneda K., Yamamoto M., and Philipsen S. GATA1 function, a paradigm for transcription factors in hematopoiesis. Mol. Cell Biol. 25 (2005) 1215-1227
    • (2005) Mol. Cell Biol. , vol.25 , pp. 1215-1227
    • Ferreira, R.1    Ohneda, K.2    Yamamoto, M.3    Philipsen, S.4
  • 24
    • 0036884695 scopus 로고    scopus 로고
    • Cellular identity and lineage choice
    • Fisher A.G. Cellular identity and lineage choice. Nat. Rev., Immunol. 2 (2002) 977-982
    • (2002) Nat. Rev., Immunol. , vol.2 , pp. 977-982
    • Fisher, A.G.1
  • 25
    • 0037071397 scopus 로고    scopus 로고
    • Transcriptional regulation of granulocyte and monocyte development
    • Friedman A.D. Transcriptional regulation of granulocyte and monocyte development. Oncogene 21 (2002) 3377-3390
    • (2002) Oncogene , vol.21 , pp. 3377-3390
    • Friedman, A.D.1
  • 26
    • 11244264337 scopus 로고    scopus 로고
    • Loss of gata1 but not gata2 converts erythropoiesis to myelopoiesis in zebrafish embryos
    • Galloway J.L., Wingert R.A., Thisse C., Thisse B., and Zon L.I. Loss of gata1 but not gata2 converts erythropoiesis to myelopoiesis in zebrafish embryos. Dev. Cell 8 (2005) 109-116
    • (2005) Dev. Cell , vol.8 , pp. 109-116
    • Galloway, J.L.1    Wingert, R.A.2    Thisse, C.3    Thisse, B.4    Zon, L.I.5
  • 27
    • 0034688174 scopus 로고    scopus 로고
    • Construction of a genetic toggle switch in Escherichia coli
    • Gardner T.S., Cantor C.R., and Collins J.J. Construction of a genetic toggle switch in Escherichia coli. Nature 403 (2000) 339-342
    • (2000) Nature , vol.403 , pp. 339-342
    • Gardner, T.S.1    Cantor, C.R.2    Collins, J.J.3
  • 28
    • 0036519296 scopus 로고    scopus 로고
    • Haematopoietic cell-fate decisions, chromatin regulation and ikaros
    • Georgopoulos K. Haematopoietic cell-fate decisions, chromatin regulation and ikaros. Nat. Rev., Immunol. 2 (2002) 162-174
    • (2002) Nat. Rev., Immunol. , vol.2 , pp. 162-174
    • Georgopoulos, K.1
  • 29
    • 0032520557 scopus 로고    scopus 로고
    • Ordered and disordered dynamics in random networks
    • Glass L., and Hill C.C. Ordered and disordered dynamics in random networks. Europhys. Lett. 41 (1998) 599-604
    • (1998) Europhys. Lett. , vol.41 , pp. 599-604
    • Glass, L.1    Hill, C.C.2
  • 30
    • 0015609281 scopus 로고
    • The logical analysis of continuous, non-linear biochemical control networks
    • Glass L., and Kauffman S.A. The logical analysis of continuous, non-linear biochemical control networks. J. Theor. Biol. 39 (1973) 103-129
    • (1973) J. Theor. Biol. , vol.39 , pp. 103-129
    • Glass, L.1    Kauffman, S.A.2
  • 31
    • 0027328670 scopus 로고
    • Is morphogenesis an intrinsically robust process?
    • Goodwin B.C., Kauffman S., and Murray J.D. Is morphogenesis an intrinsically robust process?. J. Theor. Biol. 163 (1993) 135-144
    • (1993) J. Theor. Biol. , vol.163 , pp. 135-144
    • Goodwin, B.C.1    Kauffman, S.2    Murray, J.D.3
  • 32
    • 0036566226 scopus 로고    scopus 로고
    • Differentiation plasticity of hematopoietic cells
    • Graf T. Differentiation plasticity of hematopoietic cells. Blood 99 (2002) 3089-3101
    • (2002) Blood , vol.99 , pp. 3089-3101
    • Graf, T.1
  • 34
    • 0037099497 scopus 로고    scopus 로고
    • Transcription factor-mediated lineage switching reveals plasticity in primary committed progenitor cells
    • Heyworth C., Pearson S., May G., and Enver T. Transcription factor-mediated lineage switching reveals plasticity in primary committed progenitor cells. EMBO J. 21 (2002) 3770-3781
    • (2002) EMBO J. , vol.21 , pp. 3770-3781
    • Heyworth, C.1    Pearson, S.2    May, G.3    Enver, T.4
  • 36
    • 2442583455 scopus 로고    scopus 로고
    • Regulation of cellular states in mammalian cells from a genome-wide view
    • MIT Press, Cambridge, MA
    • Huang S. Regulation of cellular states in mammalian cells from a genome-wide view. Gene Regulation and Metabolism: Post-Genomic Computational Approach (2002), MIT Press, Cambridge, MA 181-220
    • (2002) Gene Regulation and Metabolism: Post-Genomic Computational Approach , pp. 181-220
    • Huang, S.1
  • 37
    • 3042721988 scopus 로고    scopus 로고
    • Back to the biology in systems biology: what can we learn from biomolecular networks
    • Huang S. Back to the biology in systems biology: what can we learn from biomolecular networks. Brief. Funct. Genomics Proteomics 2 (2004) 279-297
    • (2004) Brief. Funct. Genomics Proteomics , vol.2 , pp. 279-297
    • Huang, S.1
  • 38
    • 33645097368 scopus 로고    scopus 로고
    • Multistability and multicellularity: cell fates as high-dimensional attractors of gene regulatory networks
    • Kriete A., and Eils R. (Eds), Elsevier Academic Press
    • Huang S. Multistability and multicellularity: cell fates as high-dimensional attractors of gene regulatory networks. In: Kriete A., and Eils R. (Eds). Computational Systems Biology (2005), Elsevier Academic Press
    • (2005) Computational Systems Biology
    • Huang, S.1
  • 39
    • 0034715919 scopus 로고    scopus 로고
    • Shape-dependent control of cell growth, differentiation, and apoptosis: switching between attractors in cell regulatory networks
    • Huang S., and Ingber D.E. Shape-dependent control of cell growth, differentiation, and apoptosis: switching between attractors in cell regulatory networks. Exp. Cell Res. 261 (2000) 91-103
    • (2000) Exp. Cell Res. , vol.261 , pp. 91-103
    • Huang, S.1    Ingber, D.E.2
  • 40
    • 18144408736 scopus 로고    scopus 로고
    • Cell fates as high-dimensional attractor states of a complex gene regulatory network
    • Huang S., Eichler G., Bar-Yam Y., and Ingber D.E. Cell fates as high-dimensional attractor states of a complex gene regulatory network. Phys. Rev. Lett. 94 (2005) 128701
    • (2005) Phys. Rev. Lett. , vol.94 , pp. 128701
    • Huang, S.1    Eichler, G.2    Bar-Yam, Y.3    Ingber, D.E.4
  • 41
    • 0034307684 scopus 로고    scopus 로고
    • Probability in transcriptional regulation and its implications for leukocyte differentiation and inducible gene expression
    • Hume D.A. Probability in transcriptional regulation and its implications for leukocyte differentiation and inducible gene expression. Blood 96 (2000) 2323-2328
    • (2000) Blood , vol.96 , pp. 2323-2328
    • Hume, D.A.1
  • 42
    • 0037961734 scopus 로고    scopus 로고
    • Molecular complexities of stem cells
    • Joshi C., and Enver T. Molecular complexities of stem cells. Curr. Opin. Hematol. 10 (2003) 220-228
    • (2003) Curr. Opin. Hematol. , vol.10 , pp. 220-228
    • Joshi, C.1    Enver, T.2
  • 43
    • 19544379881 scopus 로고    scopus 로고
    • Stochasticity in gene expression: from theories to phenotypes
    • Kaern M., Elston T.C., Blake W.J., and Collins J.J. Stochasticity in gene expression: from theories to phenotypes. Nat. Rev. Genet. 6 (2005) 451-464
    • (2005) Nat. Rev. Genet. , vol.6 , pp. 451-464
    • Kaern, M.1    Elston, T.C.2    Blake, W.J.3    Collins, J.J.4
  • 45
    • 0014489272 scopus 로고
    • Metabolic stability and epigenesis in randomly constructed genetic nets
    • Kauffman S.A. Metabolic stability and epigenesis in randomly constructed genetic nets. J. Theor. Biol. 22 (1969) 437-467
    • (1969) J. Theor. Biol. , vol.22 , pp. 437-467
    • Kauffman, S.A.1
  • 47
    • 0028841640 scopus 로고
    • In vitro differentiation of embryonic stem cells
    • Keller G.M. In vitro differentiation of embryonic stem cells. Curr. Opin. Cell. Biol. 7 (1995) 862-869
    • (1995) Curr. Opin. Cell. Biol. , vol.7 , pp. 862-869
    • Keller, G.M.1
  • 49
    • 10844254731 scopus 로고    scopus 로고
    • A panorama of lineage-specific transcription in hematopoiesis
    • Kluger Y., Lian Z., Zhang X., Newburger P.E., and Weissman S.M. A panorama of lineage-specific transcription in hematopoiesis. Bioessays 26 (2004) 1276-1287
    • (2004) Bioessays , vol.26 , pp. 1276-1287
    • Kluger, Y.1    Lian, Z.2    Zhang, X.3    Newburger, P.E.4    Weissman, S.M.5
  • 50
    • 20344363684 scopus 로고    scopus 로고
    • Mechanism of divergent growth factor effects in mesenchymal stem cell differentiation
    • Kratchmarova I., Blagoev B., Haack-Sorensen M., Kassem M., and Mann M. Mechanism of divergent growth factor effects in mesenchymal stem cell differentiation. Science 308 (2005) 1472-1477
    • (2005) Science , vol.308 , pp. 1472-1477
    • Kratchmarova, I.1    Blagoev, B.2    Haack-Sorensen, M.3    Kassem, M.4    Mann, M.5
  • 52
    • 0142027814 scopus 로고    scopus 로고
    • Structure and function of the feed-forward loop network motif
    • Mangan S., and Alon U. Structure and function of the feed-forward loop network motif. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 11980-11985
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 11980-11985
    • Mangan, S.1    Alon, U.2
  • 53
    • 23844482548 scopus 로고    scopus 로고
    • Deconstructing stemness
    • Mikkers H., and Frisen J. Deconstructing stemness. EMBO J. 24 (2005) 2715-2719
    • (2005) EMBO J. , vol.24 , pp. 2715-2719
    • Mikkers, H.1    Frisen, J.2
  • 54
    • 0036070180 scopus 로고    scopus 로고
    • Myeloid or lymphoid promiscuity as a critical step in hematopoietic lineage commitment
    • Miyamoto T., Iwasaki H., Reizis B., Ye M., Graf T., Weissman I.L., and Akashi K. Myeloid or lymphoid promiscuity as a critical step in hematopoietic lineage commitment. Dev. Cell 3 (2002) 137-147
    • (2002) Dev. Cell , vol.3 , pp. 137-147
    • Miyamoto, T.1    Iwasaki, H.2    Reizis, B.3    Ye, M.4    Graf, T.5    Weissman, I.L.6    Akashi, K.7
  • 58
    • 0034303586 scopus 로고    scopus 로고
    • Diversification of haematopoietic stem cells to specific lineages
    • Orkin S.H. Diversification of haematopoietic stem cells to specific lineages. Nat. Rev. Genet. 1 (2000) 57-64
    • (2000) Nat. Rev. Genet. , vol.1 , pp. 57-64
    • Orkin, S.H.1
  • 60
    • 27844551326 scopus 로고    scopus 로고
    • Dynamic properties of network motifs contribute to biological network organization
    • Prill R.J., Iglesias P.A., and Levchenko A. Dynamic properties of network motifs contribute to biological network organization. PLoS Biol. 3 (2005) e343
    • (2005) PLoS Biol. , vol.3
    • Prill, R.J.1    Iglesias, P.A.2    Levchenko, A.3
  • 61
    • 22244487659 scopus 로고    scopus 로고
    • Genetic regulation of stem cell origins in the mouse embryo
    • Ralston A., and Rossant J. Genetic regulation of stem cell origins in the mouse embryo. Clin Genet 68 (2005) 106-112
    • (2005) Clin Genet , vol.68 , pp. 106-112
    • Ralston, A.1    Rossant, J.2
  • 62
    • 33746040437 scopus 로고    scopus 로고
    • Towards an understanding of lineage specification in hematopoietic stem cells: a mathematical model for the interaction of transcription factors GATA-1 and PU.1
    • Roeder I., and Glauche I. Towards an understanding of lineage specification in hematopoietic stem cells: a mathematical model for the interaction of transcription factors GATA-1 and PU.1. J. Theor. Biol. 241 (2006) 852-865
    • (2006) J. Theor. Biol. , vol.241 , pp. 852-865
    • Roeder, I.1    Glauche, I.2
  • 63
    • 12844280533 scopus 로고    scopus 로고
    • Transcriptional regulation in myelopoiesis: hematopoietic fate choice, myeloid differentiation, and leukemogenesis
    • Rosmarin A.G., Yang Z., and Resendes K.K. Transcriptional regulation in myelopoiesis: hematopoietic fate choice, myeloid differentiation, and leukemogenesis. Exp. Hematol. 33 (2005) 131-143
    • (2005) Exp. Hematol. , vol.33 , pp. 131-143
    • Rosmarin, A.G.1    Yang, Z.2    Resendes, K.K.3
  • 64
    • 0029134903 scopus 로고
    • Michaelis-Menten mechanism reconsidered: implications of fractal kinetics
    • Savageau M.A. Michaelis-Menten mechanism reconsidered: implications of fractal kinetics. J. Theor. Biol. 176 (1995) 115-124
    • (1995) J. Theor. Biol. , vol.176 , pp. 115-124
    • Savageau, M.A.1
  • 65
    • 0017185026 scopus 로고
    • Non-genetic individuality: chance in the single cell
    • Spudich J.L., and Koshland Jr. D.E. Non-genetic individuality: chance in the single cell. Nature 262 (1976) 467-471
    • (1976) Nature , vol.262 , pp. 467-471
    • Spudich, J.L.1    Koshland Jr., D.E.2
  • 66
    • 33745000256 scopus 로고    scopus 로고
    • Genetic regulatory networks programming haematopoietic stem cells and erythroid lineage specification
    • Swiers G., Patient R., and Loose M. Genetic regulatory networks programming haematopoietic stem cells and erythroid lineage specification. Dev Biol. 294 (2006) 525-540
    • (2006) Dev Biol. , vol.294 , pp. 525-540
    • Swiers, G.1    Patient, R.2    Loose, M.3
  • 67
    • 0034704229 scopus 로고    scopus 로고
    • A global geometric framework for nonlinear dimensionality reduction
    • Tenenbaum J.B., de Silva V., and Langford J.C. A global geometric framework for nonlinear dimensionality reduction. Science 290 (2000) 2319-2323
    • (2000) Science , vol.290 , pp. 2319-2323
    • Tenenbaum, J.B.1    de Silva, V.2    Langford, J.C.3
  • 68
    • 0031800433 scopus 로고    scopus 로고
    • Laws for the dynamics of regulatory networks
    • Thomas R. Laws for the dynamics of regulatory networks. Int. J. Dev. Biol. 42 (1998) 479-485
    • (1998) Int. J. Dev. Biol. , vol.42 , pp. 479-485
    • Thomas, R.1
  • 69
    • 0025876999 scopus 로고
    • Functional analysis and in vivo footprinting implicate the erythroid transcription factor GATA-1 as a positive regulator of its own promoter
    • Tsai S.F., Strauss E., and Orkin S.H. Functional analysis and in vivo footprinting implicate the erythroid transcription factor GATA-1 as a positive regulator of its own promoter. Genes Dev. 5 (1991) 919-931
    • (1991) Genes Dev. , vol.5 , pp. 919-931
    • Tsai, S.F.1    Strauss, E.2    Orkin, S.H.3
  • 70
    • 33749173831 scopus 로고    scopus 로고
    • Evolution of alternative transcriptional circuits with identical logic
    • Tsong A.E., Tuch B.B., Li H., and Johnson A.D. Evolution of alternative transcriptional circuits with identical logic. Nature 443 (2006) 415-420
    • (2006) Nature , vol.443 , pp. 415-420
    • Tsong, A.E.1    Tuch, B.B.2    Li, H.3    Johnson, A.D.4
  • 73
    • 33845218548 scopus 로고    scopus 로고
    • Transcription factor profiling in individual hematopoietic progenitors by digital RT-PCR
    • Warren L., Bryder D., Weissman I.L., and Quake S.R. Transcription factor profiling in individual hematopoietic progenitors by digital RT-PCR. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 17807-17812
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 17807-17812
    • Warren, L.1    Bryder, D.2    Weissman, I.L.3    Quake, S.R.4
  • 74
    • 0027984390 scopus 로고
    • Do we understand development?
    • Wolpert L. Do we understand development?. Science 266 (1994) 571-572
    • (1994) Science , vol.266 , pp. 571-572
    • Wolpert, L.1
  • 75
    • 2542455620 scopus 로고    scopus 로고
    • Stepwise reprogramming of B cells into macrophages
    • Xie H., Ye M., Feng R., and Graf T. Stepwise reprogramming of B cells into macrophages. Cell 117 (2004) 663-676
    • (2004) Cell , vol.117 , pp. 663-676
    • Xie, H.1    Ye, M.2    Feng, R.3    Graf, T.4
  • 76
    • 0345359924 scopus 로고    scopus 로고
    • A positive-feedback-based bistable 'memory module' that governs a cell fate decision
    • Xiong W., and Ferrell Jr. J.E. A positive-feedback-based bistable 'memory module' that governs a cell fate decision. Nature 426 (2003) 460-465
    • (2003) Nature , vol.426 , pp. 460-465
    • Xiong, W.1    Ferrell Jr., J.E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.