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Volumn 38, Issue 4, 2006, Pages 431-440

The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells

Author keywords

[No Author keywords available]

Indexed keywords

OCTAMER TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NANOG; UNCLASSIFIED DRUG;

EID: 33645381936     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng1760     Document Type: Article
Times cited : (2037)

References (46)
  • 1
    • 0035189927 scopus 로고    scopus 로고
    • Embryo-derived stem cells: Of mice and men
    • Smith, A.G. Embryo-derived stem cells: of mice and men. Annu. Rev. Cell Dev. Biol. 17, 435-462 (2001).
    • (2001) Annu. Rev. Cell Dev. Biol. , vol.17 , pp. 435-462
    • Smith, A.G.1
  • 3
    • 0035498850 scopus 로고    scopus 로고
    • The end of the beginning for pluripotent stem cells
    • Donovan, P.J. & Gearhart, J. The end of the beginning for pluripotent stem cells. Nature 414, 92-97 (2001).
    • (2001) Nature , vol.414 , pp. 92-97
    • Donovan, P.J.1    Gearhart, J.2
  • 4
    • 0242690094 scopus 로고    scopus 로고
    • Lineage choice and differentiation in mouse embryos and embryonic stem cells
    • Loebel, D.A., Watson, C.M., De Young, R.A. & Tam, P.P. Lineage choice and differentiation in mouse embryos and embryonic stem cells. Dev. Biol. 264, 1-14 (2003).
    • (2003) Dev. Biol. , vol.264 , pp. 1-14
    • Loebel, D.A.1    Watson, C.M.2    De Young, R.A.3    Tam, P.P.4
  • 5
    • 0025319004 scopus 로고
    • New type of POU domain in germ line-specific protein Oct-4
    • Scholer, H.R., Ruppert, S., Suzuki, N., Chowdhury, K. & Gruss, P. New type of POU domain in germ line-specific protein Oct-4. Nature 344, 435-439 (1990).
    • (1990) Nature , vol.344 , pp. 435-439
    • Scholer, H.R.1    Ruppert, S.2    Suzuki, N.3    Chowdhury, K.4    Gruss, P.5
  • 6
    • 0032582513 scopus 로고    scopus 로고
    • Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4
    • Nichols, J. et al. Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell 95, 379-391 (1998).
    • (1998) Cell , vol.95 , pp. 379-391
    • Nichols, J.1
  • 7
    • 0034028901 scopus 로고    scopus 로고
    • Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells
    • Niwa, H., Miyazaki, J. & Smith, A.G. Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat. Genet. 24, 372-376 (2000).
    • (2000) Nat. Genet. , vol.24 , pp. 372-376
    • Niwa, H.1    Miyazaki, J.2    Smith, A.G.3
  • 8
    • 0037227099 scopus 로고    scopus 로고
    • Multipotent cell lineages in early mouse development depend on SOX2 function
    • Avilion, A.A. et al. Multipotent cell lineages in early mouse development depend on SOX2 function. Genes Dev. 17, 126-140 (2003).
    • (2003) Genes Dev. , vol.17 , pp. 126-140
    • Avilion, A.A.1
  • 9
    • 0038143611 scopus 로고    scopus 로고
    • Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells
    • Chambers, I. et al. Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell 113, 643-655 (2003).
    • (2003) Cell , vol.113 , pp. 643-655
    • Chambers, I.1
  • 10
    • 0037806031 scopus 로고    scopus 로고
    • The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells
    • Mitsui, K. et al. The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell 113, 631-642 (2003).
    • (2003) Cell , vol.113 , pp. 631-642
    • Mitsui, K.1
  • 11
    • 0034895829 scopus 로고    scopus 로고
    • Oct-4: Gatekeeper in the beginnings of mammalian development
    • Pesce, M. & Scholer, H.R. Oct-4: gatekeeper in the beginnings of mammalian development. Stem Cells 19, 271-278 (2001).
    • (2001) Stem Cells , vol.19 , pp. 271-278
    • Pesce, M.1    Scholer, H.R.2
  • 12
    • 6044269157 scopus 로고    scopus 로고
    • Self-renewal of teratocarcinoma and embryonic stem cells
    • Chambers, I. & Smith, A. Self-renewal of teratocarcinoma and embryonic stem cells. Oncogene 23, 7150-7160 (2004).
    • (2004) Oncogene , vol.23 , pp. 7150-7160
    • Chambers, I.1    Smith, A.2
  • 13
    • 20844463584 scopus 로고    scopus 로고
    • Gene identification signature (GIS) analysis for transcriptome characterization and genome annotation
    • Ng, P. et al. Gene identification signature (GIS) analysis for transcriptome characterization and genome annotation. Nat. Methods 2, 105-111 (2005).
    • (2005) Nat. Methods , vol.2 , pp. 105-111
    • Ng, P.1
  • 14
    • 30344478870 scopus 로고    scopus 로고
    • A global map of p53 transcription-factor binding sites in the human genome
    • Wei, C.L. et al. A global map of p53 transcription-factor binding sites in the human genome. Cell 124, 207-219 (2006).
    • (2006) Cell , vol.124 , pp. 207-219
    • Wei, C.L.1
  • 15
    • 21744444920 scopus 로고    scopus 로고
    • Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells
    • Chew, J.L. et al. Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells. Mol. Cell. Biol. 25, 6031-6046 (2005).
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 6031-6046
    • Chew, J.L.1
  • 16
    • 13444312083 scopus 로고    scopus 로고
    • The PANTHER database of protein families, subfamilies, functions and pathways
    • Mi, H. et al. The PANTHER database of protein families, subfamilies, functions and pathways. Nucleic Acids Res. 33, D284-D288 (2005).
    • (2005) Nucleic Acids Res. , vol.33
    • Mi, H.1
  • 17
    • 0029865895 scopus 로고    scopus 로고
    • Germline regulatory element of Oct-4 specific for the totipotent cycle of embryonal cells
    • Yeom, Y.I. et al. Germline regulatory element of Oct-4 specific for the totipotent cycle of embryonal cells. Development 122, 881-894 (1996).
    • (1996) Development , vol.122 , pp. 881-894
    • Yeom, Y.I.1
  • 18
    • 0035224579 scopus 로고    scopus 로고
    • An algorithm for finding signals of unknown length in unaligned DNA sequences
    • Pavesi, G., Mauri, G. & Pesole, G. An algorithm for finding signals of unknown length in unaligned DNA sequences. Bioinformatics 17 (Suppl.), 207-214 (2001).
    • (2001) Bioinformatics , vol.17 , Issue.SUPPL. , pp. 207-214
    • Pavesi, G.1    Mauri, G.2    Pesole, G.3
  • 19
    • 14944363825 scopus 로고    scopus 로고
    • NestedMICA: Sensitive inference of over-represented motifs in nucleic acid sequence
    • Down, T.A. & Hubbard, T.J. NestedMICA: sensitive inference of over-represented motifs in nucleic acid sequence. Nucleic Acids Res. 33, 1445-1453 (2005).
    • (2005) Nucleic Acids Res. , vol.33 , pp. 1445-1453
    • Down, T.A.1    Hubbard, T.J.2
  • 20
    • 25144525014 scopus 로고    scopus 로고
    • Core transcriptional regulatory circuitry in human embryonic stem cells
    • Boyer, L.A. et al. Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 122, 947-956 (2005).
    • (2005) Cell , vol.122 , pp. 947-956
    • Boyer, L.A.1
  • 21
    • 16844364151 scopus 로고    scopus 로고
    • LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism
    • Cartwright, P. et al. LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism. Development 132, 885-896 (2005).
    • (2005) Development , vol.132 , pp. 885-896
    • Cartwright, P.1
  • 22
    • 10744226888 scopus 로고    scopus 로고
    • Unbiased mapping of transcription factor binding sites along human chromosomes 21 and 22 points to widespread regulation of noncoding RNAs
    • Cawley, S. et al. Unbiased mapping of transcription factor binding sites along human chromosomes 21 and 22 points to widespread regulation of noncoding RNAs. Cell 116, 499-509 (2004).
    • (2004) Cell , vol.116 , pp. 499-509
    • Cawley, S.1
  • 23
    • 23844519339 scopus 로고    scopus 로고
    • A high-resolution map of active promoters in the human genome
    • Kim, T.H. et al. A high-resolution map of active promoters in the human genome. Nature 436, 876-880 (2005).
    • (2005) Nature , vol.436 , pp. 876-880
    • Kim, T.H.1
  • 24
    • 0036898231 scopus 로고    scopus 로고
    • Characterizing the physical genome
    • Pollack, J.R. & Iyer, V.R. Characterizing the physical genome. Nat. Genet. 32, 515-521 (2002).
    • (2002) Nat. Genet. , vol.32 , pp. 515-521
    • Pollack, J.R.1    Iyer, V.R.2
  • 25
    • 1242316281 scopus 로고    scopus 로고
    • ChlP-chip: Considerations for the design, analysis, and application of genome-wide chromatin immunoprecipitation experiments
    • Buck, M.J. & Lieb, J.D. ChlP-chip: considerations for the design, analysis, and application of genome-wide chromatin immunoprecipitation experiments. Genomics 83, 349-360 (2004).
    • (2004) Genomics , vol.83 , pp. 349-360
    • Buck, M.J.1    Lieb, J.D.2
  • 26
    • 19944367254 scopus 로고    scopus 로고
    • Defining the CREB regulon: A genome-wide analysis of transcription factor regulatory regions
    • Impey, S. et al. Defining the CREB regulon: a genome-wide analysis of transcription factor regulatory regions. Cell 119, 1041-1054 (2004).
    • (2004) Cell , vol.119 , pp. 1041-1054
    • Impey, S.1
  • 27
    • 18744380399 scopus 로고    scopus 로고
    • Mapping DNA-protein interactions in large genomes by sequence tag analysis of genomic enrichment
    • Kim, J., Bhinge, A.A., Morgan, X.C. & Iyer, V.R. Mapping DNA-protein interactions in large genomes by sequence tag analysis of genomic enrichment. Nat. Methods 2, 47-53 (2005).
    • (2005) Nat. Methods , vol.2 , pp. 47-53
    • Kim, J.1    Bhinge, A.A.2    Morgan, X.C.3    Iyer, V.R.4
  • 28
    • 21644434480 scopus 로고    scopus 로고
    • Transcriptional regulation of nanog by OCT4 and SOX2
    • Rodda, D.J. et al. Transcriptional regulation of nanog by OCT4 and SOX2. J. Biol. Chem. 280, 24731-24737 (2005).
    • (2005) J. Biol. Chem. , vol.280 , pp. 24731-24737
    • Rodda, D.J.1
  • 29
    • 14844359620 scopus 로고    scopus 로고
    • Octamer and Sox elements are required for transcriptional cis regulation of Nanog gene expression
    • Kuroda, T. et al. Octamer and Sox elements are required for transcriptional cis regulation of Nanog gene expression. Mol. Cell. Biol. 25, 2475-2485 (2005).
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 2475-2485
    • Kuroda, T.1
  • 30
    • 14044275706 scopus 로고    scopus 로고
    • Oct-3/4 and Sox2 regulate Oct-3/4 gene in embryonic stem cells
    • Okumura-Nakanishi, S., Saito, M., Niwa, H. & Ishikawa, F. Oct-3/4 and Sox2 regulate Oct-3/4 gene in embryonic stem cells. J. Biol. Chem. 280, 5307-5317 (2005).
    • (2005) J. Biol. Chem. , vol.280 , pp. 5307-5317
    • Okumura-Nakanishi, S.1    Saito, M.2    Niwa, H.3    Ishikawa, F.4
  • 31
    • 0034725588 scopus 로고    scopus 로고
    • Modulation of the activity of multiple transcriptional activation domains by the DNA binding domains mediates the synergistic action of Sox2 and Oct-3 on the fibroblast growth factor-4 enhancer
    • Ambrosetti, D.C., Scholer, H.R., Dailey, L. & Basilico, C. Modulation of the activity of multiple transcriptional activation domains by the DNA binding domains mediates the synergistic action of Sox2 and Oct-3 on the fibroblast growth factor-4 enhancer. J. Biol. Chem. 275, 23387-23397 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 23387-23397
    • Ambrosetti, D.C.1    Scholer, H.R.2    Dailey, L.3    Basilico, C.4
  • 32
    • 0037383685 scopus 로고    scopus 로고
    • Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development
    • Tokuzawa, Y. et al. Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development. Mol. Cell. Biol. 23, 2699-2708 (2003).
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 2699-2708
    • Tokuzawa, Y.1
  • 33
    • 0032797827 scopus 로고    scopus 로고
    • The gene for the embryonic stem cell coactivator UTF1 carries a regulatory element which selectively interacts with a complex composed of Oct-3/4 and Sox-2
    • Nishimoto, M., Fukushima, A., Okuda, A. & Muramatsu, M. The gene for the embryonic stem cell coactivator UTF1 carries a regulatory element which selectively interacts with a complex composed of Oct-3/4 and Sox-2. Mol. Cell. Biol. 19, 5453-5465 (1999).
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 5453-5465
    • Nishimoto, M.1    Fukushima, A.2    Okuda, A.3    Muramatsu, M.4
  • 34
    • 0027751867 scopus 로고
    • Understanding the homeodomain
    • Kornberg, T.B. Understanding the homeodomain. J. Biol. Chem. 268, 26813-26816 (1993).
    • (1993) J. Biol. Chem. , vol.268 , pp. 26813-26816
    • Kornberg, T.B.1
  • 35
    • 0025095819 scopus 로고
    • Homeodomain proteins and the regulation of gene expression
    • Affolter, M., Schier, A. & Gehring, W.J. Homeodomain proteins and the regulation of gene expression. Curr. Opin. Cell Biol. 2, 485-495 (1990).
    • (1990) Curr. Opin. Cell Biol. , vol.2 , pp. 485-495
    • Affolter, M.1    Schier, A.2    Gehring, W.J.3
  • 36
    • 4544319518 scopus 로고    scopus 로고
    • MPSS profiling of human embryonic stem cells
    • Brandenberger, R. et al. MPSS profiling of human embryonic stem cells. BMC Dev. Biol. 4, 10 (2004).
    • (2004) BMC Dev. Biol. , vol.4 , pp. 10
    • Brandenberger, R.1
  • 37
    • 13744252631 scopus 로고    scopus 로고
    • Transcriptome profiling of human and murine ESCs identifies divergent paths required to maintain the stem cell state
    • Wei, C.L. et al. Transcriptome profiling of human and murine ESCs identifies divergent paths required to maintain the stem cell state. Stem Cells 23, 166-185 (2005).
    • (2005) Stem Cells , vol.23 , pp. 166-185
    • Wei, C.L.1
  • 38
    • 0142027777 scopus 로고    scopus 로고
    • Distribution of NF-kappaB-binding sites across human chromosome 22
    • Martone, R. et al. Distribution of NF-kappaB-binding sites across human chromosome 22. Proc. Natl. Acad. Sci. USA 100, 12247-12252 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 12247-12252
    • Martone, R.1
  • 39
    • 0037108047 scopus 로고    scopus 로고
    • Requirement for Foxd3 in maintaining pluripotent cells of the early mouse embryo
    • Hanna, L.A., Foreman, R.K., Tarasenko, I.A., Kessler, D.S. & Labosky, P.A. Requirement for Foxd3 in maintaining pluripotent cells of the early mouse embryo. Genes Dev. 16, 2650-2661 (2002).
    • (2002) Genes Dev. , vol.16 , pp. 2650-2661
    • Hanna, L.A.1    Foreman, R.K.2    Tarasenko, I.A.3    Kessler, D.S.4    Labosky, P.A.5
  • 40
    • 0037133650 scopus 로고    scopus 로고
    • The embryonic stem cell transcription factors Oct-4 and FoxD3 interact to regulate endodermal-specific promoter expression
    • Guo, Y. et al. The embryonic stem cell transcription factors Oct-4 and FoxD3 interact to regulate endodermal-specific promoter expression. Proc. Natl. Acad. Sci. USA 99, 3663-3667 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 3663-3667
    • Guo, Y.1
  • 41
    • 1542314243 scopus 로고    scopus 로고
    • Histone H3-K9 methyltransferase ESET is essential for early development
    • Dodge, J.E., Kang, Y.K., Beppu, H., Lei, H. & Li, E. Histone H3-K9 methyltransferase ESET is essential for early development. Mol. Cell. Biol. 24, 2478-2486 (2004).
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 2478-2486
    • Dodge, J.E.1    Kang, Y.K.2    Beppu, H.3    Lei, H.4    Li, E.5
  • 42
    • 0030869565 scopus 로고    scopus 로고
    • Placental abnormalities in mouse embryos lacking the orphan nuclear receptor ERR-beta
    • Luo, J. et al. Placental abnormalities in mouse embryos lacking the orphan nuclear receptor ERR-beta. Nature 388, 778-782 (1997).
    • (1997) Nature , vol.388 , pp. 778-782
    • Luo, J.1
  • 43
    • 1442299168 scopus 로고    scopus 로고
    • Loss of PGC-specific expression of the orphan nuclear receptor ERR-beta results in reduction of germ cell number in mouse embryos
    • Mitsunaga, K. et al. Loss of PGC-specific expression of the orphan nuclear receptor ERR-beta results in reduction of germ cell number in mouse embryos. Mech. Dev. 121, 237-246 (2004).
    • (2004) Mech. Dev. , vol.121 , pp. 237-246
    • Mitsunaga, K.1
  • 44
    • 1842457513 scopus 로고    scopus 로고
    • Identification and characterisation of mRif1: A mouse telomere-associated protein highly expressed in germ cells and embryo-derived pluripotent stem cells
    • Adams, I.R. & McLaren, A. Identification and characterisation of mRif1: a mouse telomere-associated protein highly expressed in germ cells and embryo-derived pluripotent stem cells. Dev. Dyn. 229, 733-744 (2004).
    • (2004) Dev. Dyn. , vol.229 , pp. 733-744
    • Adams, I.R.1    McLaren, A.2
  • 45
    • 10344235232 scopus 로고    scopus 로고
    • Human Rif1 protein binds aberrant telomeres and aligns along anaphase midzone microtubules
    • Xu, L. & Blackburn, E.H. Human Rif1 protein binds aberrant telomeres and aligns along anaphase midzone microtubules. J. Cell Biol. 167, 819-830 (2004).
    • (2004) J. Cell Biol. , vol.167 , pp. 819-830
    • Xu, L.1    Blackburn, E.H.2
  • 46
    • 3543064379 scopus 로고    scopus 로고
    • Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint
    • Silverman, J., Takai, H., Buonomo, S.B., Eisenhaber, F. & de Lange, T. Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint. Genes Dev. 18, 2108-2119 (2004).
    • (2004) Genes Dev. , vol.18 , pp. 2108-2119
    • Silverman, J.1    Takai, H.2    Buonomo, S.B.3    Eisenhaber, F.4    De Lange, T.5


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