메뉴 건너뛰기




Volumn 36, Issue 10, 2015, Pages 661-674

Protein Tyrosine Phosphatases in Hypothalamic Insulin and Leptin Signaling

Author keywords

hypothalamus; insulin; leptin; obesity; protein tyrosine phosphatases; type 2 diabetes

Indexed keywords

INSULIN; LEPTIN; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 2; PROTEIN TYROSINE PHOSPHATASE 1B; PROTEIN TYROSINE PHOSPHATASE INHIBITOR; TRODUSQUEMINE; PROTEIN TYROSINE PHOSPHATASE;

EID: 84943405749     PISSN: 01656147     EISSN: 18733735     Source Type: Journal    
DOI: 10.1016/j.tips.2015.07.003     Document Type: Review
Times cited : (152)

References (117)
  • 1
    • 84905388767 scopus 로고    scopus 로고
    • Association between class III obesity (BMI of 40-59 kg/m2) and mortality: A pooled analysis of 20 prospective studies
    • C.M. Kitahara, and et al. Association between class III obesity (BMI of 40-59 kg/m2) and mortality: a pooled analysis of 20 prospective studies PLoS Med. 11 2014 e1001673
    • (2014) PLoS Med. , vol.11 , pp. e1001673
    • Kitahara, C.M.1
  • 2
    • 73749086904 scopus 로고    scopus 로고
    • Mortality attributable to diabetes: Estimates for the year 2010
    • G. Roglic, and N. Unwin Mortality attributable to diabetes: estimates for the year 2010 Diabetes Res. Clin. Pract. 87 2010 15 19
    • (2010) Diabetes Res. Clin. Pract. , vol.87 , pp. 15-19
    • Roglic, G.1    Unwin, N.2
  • 3
    • 84874045511 scopus 로고    scopus 로고
    • The origins and drivers of insulin resistance
    • A.M. Johnson, and J.M. Olefsky The origins and drivers of insulin resistance Cell 152 2013 673 684
    • (2013) Cell , vol.152 , pp. 673-684
    • Johnson, A.M.1    Olefsky, J.M.2
  • 4
    • 84923171580 scopus 로고    scopus 로고
    • Genetic studies of body mass index yield new insights for obesity biology
    • A.E. Locke, and et al. Genetic studies of body mass index yield new insights for obesity biology Nature 518 2015 197 206
    • (2015) Nature , vol.518 , pp. 197-206
    • Locke, A.E.1
  • 5
    • 84870624154 scopus 로고    scopus 로고
    • Leptin and insulin pathways in POMC and AgRP neurons that modulate energy balance and glucose homeostasis
    • L. Varela, and T.L. Horvath Leptin and insulin pathways in POMC and AgRP neurons that modulate energy balance and glucose homeostasis EMBO Rep. 13 2012 1079 1086
    • (2012) EMBO Rep. , vol.13 , pp. 1079-1086
    • Varela, L.1    Horvath, T.L.2
  • 6
    • 84872770077 scopus 로고    scopus 로고
    • PTP1B and TCPTP - Nonredundant phosphatases in insulin signaling and glucose homeostasis
    • T. Tiganis PTP1B and TCPTP - nonredundant phosphatases in insulin signaling and glucose homeostasis FEBS J. 280 2013 445 458
    • (2013) FEBS J. , vol.280 , pp. 445-458
    • Tiganis, T.1
  • 7
    • 84858066573 scopus 로고    scopus 로고
    • Modulation of leptin resistance by protein tyrosine phosphatases
    • J. St-Pierre, and M.L. Tremblay Modulation of leptin resistance by protein tyrosine phosphatases Cell Metab. 15 2012 292 297
    • (2012) Cell Metab. , vol.15 , pp. 292-297
    • St-Pierre, J.1    Tremblay, M.L.2
  • 8
    • 13344295079 scopus 로고    scopus 로고
    • Serum immunoreactive-leptin concentrations in normal-weight and obese humans
    • R.V. Considine, and et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans N. Engl. J. Med. 334 1996 292 295
    • (1996) N. Engl. J. Med. , vol.334 , pp. 292-295
    • Considine, R.V.1
  • 9
    • 0028793697 scopus 로고
    • Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action
    • R.C. Frederich, and et al. Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action Nat. Med. 1 1995 1311 1314
    • (1995) Nat. Med. , vol.1 , pp. 1311-1314
    • Frederich, R.C.1
  • 10
    • 0028845877 scopus 로고
    • Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
    • M. Maffei, and et al. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects Nat. Med. 1 1995 1155 1161
    • (1995) Nat. Med. , vol.1 , pp. 1155-1161
    • Maffei, M.1
  • 11
    • 30644473109 scopus 로고    scopus 로고
    • Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis
    • H. Dhillon, and et al. Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis Neuron 49 2006 191 203
    • (2006) Neuron , vol.49 , pp. 191-203
    • Dhillon, H.1
  • 12
    • 2942733252 scopus 로고    scopus 로고
    • Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis
    • N. Balthasar, and et al. Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis Neuron 42 2004 983 991
    • (2004) Neuron , vol.42 , pp. 983-991
    • Balthasar, N.1
  • 13
    • 17844389670 scopus 로고    scopus 로고
    • The hypothalamic arcuate nucleus: A key site for mediating leptin's effects on glucose homeostasis and locomotor activity
    • R. Coppari, and et al. The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity Cell Metab. 1 2005 63 72
    • (2005) Cell Metab. , vol.1 , pp. 63-72
    • Coppari, R.1
  • 14
    • 77955296183 scopus 로고    scopus 로고
    • Disruption of hypothalamic leptin signaling in mice leads to early-onset obesity, but physiological adaptations in mature animals stabilize adiposity levels
    • L.E. Ring, and L.M. Zeltser Disruption of hypothalamic leptin signaling in mice leads to early-onset obesity, but physiological adaptations in mature animals stabilize adiposity levels J. Clin. Invest. 120 2010 2931 2941
    • (2010) J. Clin. Invest. , vol.120 , pp. 2931-2941
    • Ring, L.E.1    Zeltser, L.M.2
  • 15
    • 84907968471 scopus 로고    scopus 로고
    • The thermogenic effect of leptin is dependent on a distinct population of prolactin-releasing peptide neurons in the dorsomedial hypothalamus
    • G.T. Dodd, and et al. The thermogenic effect of leptin is dependent on a distinct population of prolactin-releasing peptide neurons in the dorsomedial hypothalamus Cell Metab. 20 2014 639 649
    • (2014) Cell Metab. , vol.20 , pp. 639-649
    • Dodd, G.T.1
  • 16
    • 79957896911 scopus 로고    scopus 로고
    • Leptin receptor expression in hindbrain Glp-1 neurons regulates food intake and energy balance in mice
    • M.M. Scott, and et al. Leptin receptor expression in hindbrain Glp-1 neurons regulates food intake and energy balance in mice J. Clin. Invest. 121 2011 2413 2421
    • (2011) J. Clin. Invest. , vol.121 , pp. 2413-2421
    • Scott, M.M.1
  • 17
    • 72649103549 scopus 로고    scopus 로고
    • Endogenous leptin signaling in the caudal nucleus tractus solitarius and area postrema is required for energy balance regulation
    • M.R. Hayes, and et al. Endogenous leptin signaling in the caudal nucleus tractus solitarius and area postrema is required for energy balance regulation Cell Metab. 11 2010 77 83
    • (2010) Cell Metab. , vol.11 , pp. 77-83
    • Hayes, M.R.1
  • 18
    • 58749086043 scopus 로고    scopus 로고
    • The geometry of leptin action in the brain: More complicated than a simple ARC
    • M.G. Myers Jr, and et al. The geometry of leptin action in the brain: more complicated than a simple ARC Cell Metab. 9 2009 117 123
    • (2009) Cell Metab. , vol.9 , pp. 117-123
    • Myers, M.G.1
  • 19
    • 0029864416 scopus 로고    scopus 로고
    • Leptin enters the brain by a saturable system independent of insulin
    • W.A. Banks, and et al. Leptin enters the brain by a saturable system independent of insulin Peptides 17 1996 305 311
    • (1996) Peptides , vol.17 , pp. 305-311
    • Banks, W.A.1
  • 20
    • 84893434815 scopus 로고    scopus 로고
    • Hypothalamic tanycytes are an ERK-gated conduit for leptin into the brain
    • E. Balland, and et al. Hypothalamic tanycytes are an ERK-gated conduit for leptin into the brain Cell Metab. 19 2014 293 301
    • (2014) Cell Metab. , vol.19 , pp. 293-301
    • Balland, E.1
  • 21
    • 16244388931 scopus 로고    scopus 로고
    • Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis
    • T.K. Lam, and et al. Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis Nat. Med. 11 2005 320 327
    • (2005) Nat. Med. , vol.11 , pp. 320-327
    • Lam, T.K.1
  • 22
    • 34548604499 scopus 로고    scopus 로고
    • Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity
    • L.E. Parton, and et al. Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity Nature 449 2007 228 232
    • (2007) Nature , vol.449 , pp. 228-232
    • Parton, L.E.1
  • 23
    • 84873131782 scopus 로고    scopus 로고
    • Hypothalamic control of energy balance: Insights into the role of synaptic plasticity
    • M.O. Dietrich, and T.L. Horvath Hypothalamic control of energy balance: insights into the role of synaptic plasticity Trends Neurosci. 36 2013 65 73
    • (2013) Trends Neurosci. , vol.36 , pp. 65-73
    • Dietrich, M.O.1    Horvath, T.L.2
  • 24
    • 0035942777 scopus 로고    scopus 로고
    • Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
    • M.A. Cowley, and et al. Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus Nature 411 2001 480 484
    • (2001) Nature , vol.411 , pp. 480-484
    • Cowley, M.A.1
  • 25
    • 50249120768 scopus 로고    scopus 로고
    • Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance
    • Q. Tong, and et al. Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance Nat. Neurosci. 11 2008 998 1000
    • (2008) Nat. Neurosci. , vol.11 , pp. 998-1000
    • Tong, Q.1
  • 26
    • 2142758640 scopus 로고    scopus 로고
    • Orexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus
    • M. van den Top, and et al. Orexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus Nat. Neurosci. 7 2004 493 494
    • (2004) Nat. Neurosci. , vol.7 , pp. 493-494
    • Van Den Top, M.1
  • 27
    • 2942631413 scopus 로고    scopus 로고
    • Proopiomelanocortin and energy balance: Insights from human and murine genetics
    • A.P. Coll, and et al. Proopiomelanocortin and energy balance: insights from human and murine genetics J. Clin. Endocrinol. Metab. 89 2004 2557 2562
    • (2004) J. Clin. Endocrinol. Metab. , vol.89 , pp. 2557-2562
    • Coll, A.P.1
  • 28
    • 84907867610 scopus 로고    scopus 로고
    • 20 years of leptin: Connecting leptin signaling to biological function
    • M.B. Allison, and M.G. Myers Jr 20 years of leptin: connecting leptin signaling to biological function J. Endocrinol. 223 2014 T25 T35
    • (2014) J. Endocrinol. , vol.223 , pp. T25-T35
    • Allison, M.B.1    Myers, M.G.2
  • 29
    • 84863535512 scopus 로고    scopus 로고
    • P70S6 kinase phosphorylates AMPK on serine 491 to mediate leptin's effect on food intake
    • Y. Dagon, and et al. p70S6 kinase phosphorylates AMPK on serine 491 to mediate leptin's effect on food intake Cell Metab. 16 2012 104 112
    • (2012) Cell Metab. , vol.16 , pp. 104-112
    • Dagon, Y.1
  • 30
    • 43049116846 scopus 로고    scopus 로고
    • Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice
    • J.W. Hill, and et al. Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice J. Clin. Invest. 118 2008 1796 1805
    • (2008) J. Clin. Invest. , vol.118 , pp. 1796-1805
    • Hill, J.W.1
  • 31
    • 0034703229 scopus 로고    scopus 로고
    • Role of brain insulin receptor in control of body weight and reproduction
    • J.C. Bruning, and et al. Role of brain insulin receptor in control of body weight and reproduction Science 289 2000 2122 2125
    • (2000) Science , vol.289 , pp. 2122-2125
    • Bruning, J.C.1
  • 32
    • 0036267472 scopus 로고    scopus 로고
    • Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats
    • S. Obici, and et al. Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats Nat. Neurosci. 5 2002 566 572
    • (2002) Nat. Neurosci. , vol.5 , pp. 566-572
    • Obici, S.1
  • 33
    • 0036913187 scopus 로고    scopus 로고
    • Hypothalamic insulin signaling is required for inhibition of glucose production
    • S. Obici, and et al. Hypothalamic insulin signaling is required for inhibition of glucose production Nat. Med. 8 2002 1376 1382
    • (2002) Nat. Med. , vol.8 , pp. 1376-1382
    • Obici, S.1
  • 34
    • 0037315042 scopus 로고    scopus 로고
    • Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: A key mediator of insulin-induced anorexia
    • K.D. Niswender, and et al. Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia Diabetes 52 2003 227 231
    • (2003) Diabetes , vol.52 , pp. 227-231
    • Niswender, K.D.1
  • 35
    • 33645071314 scopus 로고    scopus 로고
    • Insulin action in the brain contributes to glucose lowering during insulin treatment of diabetes
    • R.W. Gelling, and et al. Insulin action in the brain contributes to glucose lowering during insulin treatment of diabetes Cell Metab. 3 2006 67 73
    • (2006) Cell Metab. , vol.3 , pp. 67-73
    • Gelling, R.W.1
  • 36
    • 45749158925 scopus 로고    scopus 로고
    • Central insulin action regulates peripheral glucose and fat metabolism in mice
    • L. Koch, and et al. Central insulin action regulates peripheral glucose and fat metabolism in mice J. Clin. Invest. 118 2008 2132 2147
    • (2008) J. Clin. Invest. , vol.118 , pp. 2132-2147
    • Koch, L.1
  • 37
    • 0018621289 scopus 로고
    • Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons
    • S.C. Woods, and et al. Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons Nature 282 1979 503 505
    • (1979) Nature , vol.282 , pp. 503-505
    • Woods, S.C.1
  • 38
    • 79551506567 scopus 로고    scopus 로고
    • Brain insulin controls adipose tissue lipolysis and lipogenesis
    • T. Scherer, and et al. Brain insulin controls adipose tissue lipolysis and lipogenesis Cell Metab. 13 2011 183 194
    • (2011) Cell Metab. , vol.13 , pp. 183-194
    • Scherer, T.1
  • 39
    • 84920972410 scopus 로고    scopus 로고
    • Leptin and insulin act on POMC neurons to promote the browning of white fat
    • G.T. Dodd, and et al. Leptin and insulin act on POMC neurons to promote the browning of white fat Cell 160 2015 88 104
    • (2015) Cell , vol.160 , pp. 88-104
    • Dodd, G.T.1
  • 40
    • 33645579324 scopus 로고    scopus 로고
    • Role of hepatic STAT3 in brain-insulin action on hepatic glucose production
    • H. Inoue, and et al. Role of hepatic STAT3 in brain-insulin action on hepatic glucose production Cell Metab. 3 2006 267 275
    • (2006) Cell Metab. , vol.3 , pp. 267-275
    • Inoue, H.1
  • 41
    • 34249651956 scopus 로고    scopus 로고
    • Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production
    • A.C. Konner, and et al. Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production Cell Metab. 5 2007 438 449
    • (2007) Cell Metab. , vol.5 , pp. 438-449
    • Konner, A.C.1
  • 42
    • 17844379717 scopus 로고    scopus 로고
    • Hypothalamic K(ATP) channels control hepatic glucose production
    • A. Pocai, and et al. Hypothalamic K(ATP) channels control hepatic glucose production Nature 434 2005 1026 1031
    • (2005) Nature , vol.434 , pp. 1026-1031
    • Pocai, A.1
  • 43
    • 0033944152 scopus 로고    scopus 로고
    • + channels in hypothalamic neurons of lean, but not obese rats
    • + channels in hypothalamic neurons of lean, but not obese rats Nat. Neurosci. 3 2000 757 758
    • (2000) Nat. Neurosci. , vol.3 , pp. 757-758
    • Spanswick, D.1
  • 44
    • 77249146406 scopus 로고    scopus 로고
    • Segregation of acute leptin and insulin effects in distinct populations of arcuate proopiomelanocortin neurons
    • K.W. Williams, and et al. Segregation of acute leptin and insulin effects in distinct populations of arcuate proopiomelanocortin neurons J. Neurosci. 30 2010 2472 2479
    • (2010) J. Neurosci. , vol.30 , pp. 2472-2479
    • Williams, K.W.1
  • 45
    • 84897507249 scopus 로고    scopus 로고
    • Insulin excites anorexigenic proopiomelanocortin neurons via activation of canonical transient receptor potential channels
    • J. Qiu, and et al. Insulin excites anorexigenic proopiomelanocortin neurons via activation of canonical transient receptor potential channels Cell Metab. 19 2014 682 693
    • (2014) Cell Metab. , vol.19 , pp. 682-693
    • Qiu, J.1
  • 46
    • 9644260562 scopus 로고    scopus 로고
    • Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus
    • N. Kubota, and et al. Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus J. Clin. Invest. 114 2004 917 927
    • (2004) J. Clin. Invest. , vol.114 , pp. 917-927
    • Kubota, N.1
  • 47
    • 84911916822 scopus 로고    scopus 로고
    • Central insulin administration improves whole-body insulin sensitivity via hypothalamus and parasympathetic outputs in men
    • M. Heni, and et al. Central insulin administration improves whole-body insulin sensitivity via hypothalamus and parasympathetic outputs in men Diabetes 63 2014 4083 4088
    • (2014) Diabetes , vol.63 , pp. 4083-4088
    • Heni, M.1
  • 48
    • 84928209333 scopus 로고    scopus 로고
    • Intranasal insulin suppresses endogenous glucose production in humans compared with placebo in the presence of similar venous insulin concentrations
    • S. Dash, and et al. Intranasal insulin suppresses endogenous glucose production in humans compared with placebo in the presence of similar venous insulin concentrations Diabetes 64 2015 766 774
    • (2015) Diabetes , vol.64 , pp. 766-774
    • Dash, S.1
  • 49
    • 77949673935 scopus 로고    scopus 로고
    • PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice
    • R. Banno, and et al. PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice J. Clin. Invest. 120 2010 720 734
    • (2010) J. Clin. Invest. , vol.120 , pp. 720-734
    • Banno, R.1
  • 50
    • 8644268830 scopus 로고    scopus 로고
    • Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism
    • E.E. Zhang, and et al. Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism Proc. Natl. Acad. Sci. U.S.A. 101 2004 16064 16069
    • (2004) Proc. Natl. Acad. Sci. U.S.A. , vol.101 , pp. 16064-16069
    • Zhang, E.E.1
  • 51
    • 33746810001 scopus 로고    scopus 로고
    • Neuronal PTP1B regulates body weight, adiposity and leptin action
    • K.K. Bence, and et al. Neuronal PTP1B regulates body weight, adiposity and leptin action Nat. Med. 12 2006 917 924
    • (2006) Nat. Med. , vol.12 , pp. 917-924
    • Bence, K.K.1
  • 52
    • 18344379861 scopus 로고    scopus 로고
    • PTP1B regulates leptin signal transduction in vivo
    • J.M. Zabolotny, and et al. PTP1B regulates leptin signal transduction in vivo Dev. Cell 2 2002 489 495
    • (2002) Dev. Cell , vol.2 , pp. 489-495
    • Zabolotny, J.M.1
  • 53
    • 0036228770 scopus 로고    scopus 로고
    • Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B
    • A. Cheng, and et al. Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B Dev. Cell 2 2002 497 503
    • (2002) Dev. Cell , vol.2 , pp. 497-503
    • Cheng, A.1
  • 54
    • 84897110775 scopus 로고    scopus 로고
    • Improved metabolic phenotype of hypothalamic PTP1B-deficiency is dependent upon the leptin receptor
    • R.C. Tsou, and et al. Improved metabolic phenotype of hypothalamic PTP1B-deficiency is dependent upon the leptin receptor Mol. Metab. 3 2014 301 312
    • (2014) Mol. Metab. , vol.3 , pp. 301-312
    • Tsou, R.C.1
  • 55
    • 79955599937 scopus 로고    scopus 로고
    • Protein tyrosine phosphatase epsilon affects body weight by downregulating leptin signaling in a phosphorylation-dependent manner
    • L. Rousso-Noori, and et al. Protein tyrosine phosphatase epsilon affects body weight by downregulating leptin signaling in a phosphorylation-dependent manner Cell Metab. 13 2011 562 572
    • (2011) Cell Metab. , vol.13 , pp. 562-572
    • Rousso-Noori, L.1
  • 56
    • 80455122701 scopus 로고    scopus 로고
    • Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance
    • K. Loh, and et al. Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance Cell Metab. 14 2011 684 699
    • (2011) Cell Metab. , vol.14 , pp. 684-699
    • Loh, K.1
  • 57
    • 33745819212 scopus 로고    scopus 로고
    • Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity
    • L. Plum, and et al. Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity J. Clin. Invest. 116 2006 1886 1901
    • (2006) J. Clin. Invest. , vol.116 , pp. 1886-1901
    • Plum, L.1
  • 58
    • 47249148827 scopus 로고    scopus 로고
    • Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo
    • J.M. Zabolotny, and et al. Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo J. Biol. Chem. 283 2008 14230 14241
    • (2008) J. Biol. Chem. , vol.283 , pp. 14230-14241
    • Zabolotny, J.M.1
  • 59
    • 0035930501 scopus 로고    scopus 로고
    • TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B
    • M.P. Myers, and et al. TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B J. Biol. Chem. 276 2001 47771 47774
    • (2001) J. Biol. Chem. , vol.276 , pp. 47771-47774
    • Myers, M.P.1
  • 60
    • 0031055324 scopus 로고    scopus 로고
    • Development of 'substrate-trapping' mutants to identify physiological substrates of protein tyrosine phosphatases
    • A.J. Flint, and et al. Development of 'substrate-trapping' mutants to identify physiological substrates of protein tyrosine phosphatases Proc. Natl. Acad. Sci. U.S.A. 94 1997 1680 1685
    • (1997) Proc. Natl. Acad. Sci. U.S.A. , vol.94 , pp. 1680-1685
    • Flint, A.J.1
  • 61
    • 0033525870 scopus 로고    scopus 로고
    • Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene
    • M. Elchebly, and et al. Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene Science 283 1999 1544 1548
    • (1999) Science , vol.283 , pp. 1544-1548
    • Elchebly, M.1
  • 62
    • 0033942614 scopus 로고    scopus 로고
    • Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice
    • L.D. Klaman, and et al. Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice Mol. Cell. Biol. 20 2000 5479 5489
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 5479-5489
    • Klaman, L.D.1
  • 63
    • 62749115187 scopus 로고    scopus 로고
    • Liver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced ER stress
    • M. Delibegovic, and et al. Liver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced ER stress Diabetes 58 2009 590 599
    • (2009) Diabetes , vol.58 , pp. 590-599
    • Delibegovic, M.1
  • 64
    • 47949090359 scopus 로고    scopus 로고
    • Reduction of hypothalamic protein tyrosine phosphatase improves insulin and leptin resistance in diet-induced obese rats
    • P.K. Picardi, and et al. Reduction of hypothalamic protein tyrosine phosphatase improves insulin and leptin resistance in diet-induced obese rats Endocrinology 149 2008 3870 3880
    • (2008) Endocrinology , vol.149 , pp. 3870-3880
    • Picardi, P.K.1
  • 65
    • 84874104450 scopus 로고    scopus 로고
    • Binge drinking induces whole-body insulin resistance by impairing hypothalamic insulin action
    • C. Lindtner, and et al. Binge drinking induces whole-body insulin resistance by impairing hypothalamic insulin action Sci. Transl. Med. 5 2013 170ra114
    • (2013) Sci. Transl. Med. , vol.5 , pp. 170ra114
    • Lindtner, C.1
  • 66
    • 84907014635 scopus 로고    scopus 로고
    • Ventromedial hypothalamus-specific Ptpn1 deletion exacerbates diet-induced obesity in female mice
    • F. Chiappini, and et al. Ventromedial hypothalamus-specific Ptpn1 deletion exacerbates diet-induced obesity in female mice J. Clin. Invest. 124 2014 3781 3792
    • (2014) J. Clin. Invest. , vol.124 , pp. 3781-3792
    • Chiappini, F.1
  • 67
    • 0037371765 scopus 로고    scopus 로고
    • Regulation of insulin receptor signaling by the protein tyrosine phosphatase TCPTP
    • S. Galic, and et al. Regulation of insulin receptor signaling by the protein tyrosine phosphatase TCPTP Mol. Cell. Biol. 23 2003 2096 2108
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 2096-2108
    • Galic, S.1
  • 68
    • 78049311283 scopus 로고    scopus 로고
    • Obesity and leptin resistance: Distinguishing cause from effect
    • M.G. Myers Jr, and et al. Obesity and leptin resistance: distinguishing cause from effect Trends Endocrinol. Metab. 21 2010 643 651
    • (2010) Trends Endocrinol. Metab. , vol.21 , pp. 643-651
    • Myers, M.G.1
  • 69
    • 77951918926 scopus 로고    scopus 로고
    • Macrophages, inflammation, and insulin resistance
    • J.M. Olefsky, and C.K. Glass Macrophages, inflammation, and insulin resistance Annu. Rev. Physiol. 72 2010 219 246
    • (2010) Annu. Rev. Physiol. , vol.72 , pp. 219-246
    • Olefsky, J.M.1    Glass, C.K.2
  • 70
    • 84857861919 scopus 로고    scopus 로고
    • Mechanisms for insulin resistance: Common threads and missing links
    • V.T. Samuel, and G.I. Shulman Mechanisms for insulin resistance: common threads and missing links Cell 148 2012 852 871
    • (2012) Cell , vol.148 , pp. 852-871
    • Samuel, V.T.1    Shulman, G.I.2
  • 71
    • 5644231992 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
    • U. Ozcan, and et al. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes Science 306 2004 457 461
    • (2004) Science , vol.306 , pp. 457-461
    • Ozcan, U.1
  • 72
    • 24944438230 scopus 로고    scopus 로고
    • Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus
    • C.T. De Souza, and et al. Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus Endocrinology 146 2005 4192 4199
    • (2005) Endocrinology , vol.146 , pp. 4192-4199
    • De Souza, C.T.1
  • 73
    • 33747058235 scopus 로고    scopus 로고
    • The cerebrocortical response to hyperinsulinemia is reduced in overweight humans: A magnetoencephalographic study
    • O. Tschritter, and et al. The cerebrocortical response to hyperinsulinemia is reduced in overweight humans: a magnetoencephalographic study Proc. Natl. Acad. Sci. U.S.A. 103 2006 12103 12108
    • (2006) Proc. Natl. Acad. Sci. U.S.A. , vol.103 , pp. 12103-12108
    • Tschritter, O.1
  • 74
    • 84931289812 scopus 로고    scopus 로고
    • Effects of intranasal insulin on hepatic fat accumulation and energy metabolism in humans
    • S. Gancheva, and et al. Effects of intranasal insulin on hepatic fat accumulation and energy metabolism in humans Diabetes 64 2015 1966 1975
    • (2015) Diabetes , vol.64 , pp. 1966-1975
    • Gancheva, S.1
  • 75
    • 0030594830 scopus 로고    scopus 로고
    • Decreased cerebrospinal-fluid/serum leptin ratio in obesity: A possible mechanism for leptin resistance
    • J.F. Caro, and et al. Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance Lancet 348 1996 159 161
    • (1996) Lancet , vol.348 , pp. 159-161
    • Caro, J.F.1
  • 76
    • 0029881125 scopus 로고    scopus 로고
    • Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans
    • M.W. Schwartz, and et al. Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans Nat. Med. 2 1996 589 593
    • (1996) Nat. Med. , vol.2 , pp. 589-593
    • Schwartz, M.W.1
  • 77
    • 0030807358 scopus 로고    scopus 로고
    • Diet-induced obese mice develop peripheral, but not central, resistance to leptin
    • M. Van Heek, and et al. Diet-induced obese mice develop peripheral, but not central, resistance to leptin J. Clin. Invest. 99 1997 385 390
    • (1997) J. Clin. Invest. , vol.99 , pp. 385-390
    • Van Heek, M.1
  • 78
    • 52949096557 scopus 로고    scopus 로고
    • Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity
    • X. Zhang, and et al. Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity Cell 135 2008 61 73
    • (2008) Cell , vol.135 , pp. 61-73
    • Zhang, X.1
  • 79
    • 57849115277 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress plays a central role in development of leptin resistance
    • L. Ozcan, and et al. Endoplasmic reticulum stress plays a central role in development of leptin resistance Cell Metab. 9 2009 35 51
    • (2009) Cell Metab. , vol.9 , pp. 35-51
    • Ozcan, L.1
  • 80
    • 78650071301 scopus 로고    scopus 로고
    • Combined neural inactivation of SOCS-3 and PTP-1B reveal additive, synergistic, and factor-specific roles in the regulation of body energy balance
    • N. Briancon, and et al. Combined neural inactivation of SOCS-3 and PTP-1B reveal additive, synergistic, and factor-specific roles in the regulation of body energy balance Diabetes 59 2010 3074 3084
    • (2010) Diabetes , vol.59 , pp. 3074-3084
    • Briancon, N.1
  • 81
    • 33746537247 scopus 로고    scopus 로고
    • Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells
    • P. Kievit, and et al. Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells Cell Metab. 4 2006 123 132
    • (2006) Cell Metab. , vol.4 , pp. 123-132
    • Kievit, P.1
  • 82
    • 3142782772 scopus 로고    scopus 로고
    • Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3
    • J.K. Howard, and et al. Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3 Nat. Med. 10 2004 734 738
    • (2004) Nat. Med. , vol.10 , pp. 734-738
    • Howard, J.K.1
  • 83
    • 77955052291 scopus 로고    scopus 로고
    • Inhibition of PTP1B by trodusquemine (MSI-1436) causes fat-specific weight loss in diet-induced obese mice
    • K.A. Lantz, and et al. Inhibition of PTP1B by trodusquemine (MSI-1436) causes fat-specific weight loss in diet-induced obese mice Obesity 18 2010 1516 1523
    • (2010) Obesity , vol.18 , pp. 1516-1523
    • Lantz, K.A.1
  • 84
    • 84913530022 scopus 로고    scopus 로고
    • Xbp1s in POMC neurons connects ER stress with energy balance and glucose homeostasis
    • K.W. Williams, and et al. Xbp1s in POMC neurons connects ER stress with energy balance and glucose homeostasis Cell Metab. 20 2014 471 482
    • (2014) Cell Metab. , vol.20 , pp. 471-482
    • Williams, K.W.1
  • 85
    • 0030840724 scopus 로고    scopus 로고
    • Alterations in skeletal muscle protein-tyrosine phosphatase activity and expression in insulin-resistant human obesity and diabetes
    • F. Ahmad, and et al. Alterations in skeletal muscle protein-tyrosine phosphatase activity and expression in insulin-resistant human obesity and diabetes J. Clin. Invest. 100 1997 449 458
    • (1997) J. Clin. Invest. , vol.100 , pp. 449-458
    • Ahmad, F.1
  • 86
    • 84892727198 scopus 로고    scopus 로고
    • What we talk about when we talk about fat
    • E.D. Rosen, and B.M. Spiegelman What we talk about when we talk about fat Cell 156 2014 20 44
    • (2014) Cell , vol.156 , pp. 20-44
    • Rosen, E.D.1    Spiegelman, B.M.2
  • 87
    • 78650945931 scopus 로고    scopus 로고
    • Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice
    • P. Seale, and et al. Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice J. Clin. Invest. 121 2011 96 105
    • (2011) J. Clin. Invest. , vol.121 , pp. 96-105
    • Seale, P.1
  • 88
    • 84892702771 scopus 로고    scopus 로고
    • Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch
    • P. Cohen, and et al. Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch Cell 156 2014 304 316
    • (2014) Cell , vol.156 , pp. 304-316
    • Cohen, P.1
  • 89
    • 78650098848 scopus 로고    scopus 로고
    • Outdoor temperature, age, sex, body mass index, and diabetic status determine the prevalence, mass, and glucose-uptake activity of 18F-FDG-detected BAT in humans
    • V. Ouellet, and et al. Outdoor temperature, age, sex, body mass index, and diabetic status determine the prevalence, mass, and glucose-uptake activity of 18F-FDG-detected BAT in humans J. Clin. Endocrinol. Metab. 96 2011 192 199
    • (2011) J. Clin. Endocrinol. Metab. , vol.96 , pp. 192-199
    • Ouellet, V.1
  • 90
    • 84916878247 scopus 로고    scopus 로고
    • O-GlcNAc transferase enables AgRP neurons to suppress browning of white fat
    • H.B. Ruan, and et al. O-GlcNAc transferase enables AgRP neurons to suppress browning of white fat Cell 159 2014 306 317
    • (2014) Cell , vol.159 , pp. 306-317
    • Ruan, H.B.1
  • 91
    • 58249138122 scopus 로고    scopus 로고
    • Large-scale structural analysis of the classical human protein tyrosine phosphatome
    • A.J. Barr, and et al. Large-scale structural analysis of the classical human protein tyrosine phosphatome Cell 136 2009 352 363
    • (2009) Cell , vol.136 , pp. 352-363
    • Barr, A.J.1
  • 92
    • 3543017313 scopus 로고    scopus 로고
    • Allosteric inhibition of protein tyrosine phosphatase 1B
    • C. Wiesmann, and et al. Allosteric inhibition of protein tyrosine phosphatase 1B Nat. Struct. Mol. Biol. 11 2004 730 737
    • (2004) Nat. Struct. Mol. Biol. , vol.11 , pp. 730-737
    • Wiesmann, C.1
  • 93
    • 84902852963 scopus 로고    scopus 로고
    • Targeting the disordered C terminus of PTP1B with an allosteric inhibitor
    • N. Krishnan, and et al. Targeting the disordered C terminus of PTP1B with an allosteric inhibitor Nat. Chem. Biol. 10 2014 558 566
    • (2014) Nat. Chem. Biol. , vol.10 , pp. 558-566
    • Krishnan, N.1
  • 94
    • 0036181649 scopus 로고    scopus 로고
    • Protein tyrosine phosphatases: Structure and function, substrate specificity, and inhibitor development
    • Z.Y. Zhang Protein tyrosine phosphatases: structure and function, substrate specificity, and inhibitor development Annu. Rev. Pharmacol. Toxicol. 42 2002 209 234
    • (2002) Annu. Rev. Pharmacol. Toxicol. , vol.42 , pp. 209-234
    • Zhang, Z.Y.1
  • 95
    • 0031457541 scopus 로고    scopus 로고
    • Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: A paradigm for inhibitor design
    • Y.A. Puius, and et al. Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: a paradigm for inhibitor design Proc. Natl. Acad. Sci. U.S.A. 94 1997 13420 13425
    • (1997) Proc. Natl. Acad. Sci. U.S.A. , vol.94 , pp. 13420-13425
    • Puius, Y.A.1
  • 96
    • 77949845981 scopus 로고    scopus 로고
    • Recent advances in the discovery of competitive protein tyrosine phosphatase 1B inhibitors for the treatment of diabetes, obesity, and cancer
    • A.P. Combs Recent advances in the discovery of competitive protein tyrosine phosphatase 1B inhibitors for the treatment of diabetes, obesity, and cancer J. Med. Chem. 53 2010 2333 2344
    • (2010) J. Med. Chem. , vol.53 , pp. 2333-2344
    • Combs, A.P.1
  • 97
    • 84857911995 scopus 로고    scopus 로고
    • Bicyclic benzofuran and indole-based salicylic acids as protein tyrosine phosphatase inhibitors
    • Y. He, and et al. Bicyclic benzofuran and indole-based salicylic acids as protein tyrosine phosphatase inhibitors Bioorg. Med. Chem. 20 2012 1940 1946
    • (2012) Bioorg. Med. Chem. , vol.20 , pp. 1940-1946
    • He, Y.1
  • 98
    • 84872783533 scopus 로고    scopus 로고
    • Small molecule tools for functional interrogation of protein tyrosine phosphatases
    • R. He, and et al. Small molecule tools for functional interrogation of protein tyrosine phosphatases FEBS J. 280 2013 731 750
    • (2013) FEBS J. , vol.280 , pp. 731-750
    • He, R.1
  • 99
    • 0035861668 scopus 로고    scopus 로고
    • Acquisition of a specific and potent PTP1B inhibitor from a novel combinatorial library and screening procedure
    • K. Shen, and et al. Acquisition of a specific and potent PTP1B inhibitor from a novel combinatorial library and screening procedure J. Biol. Chem. 276 2001 47311 47319
    • (2001) J. Biol. Chem. , vol.276 , pp. 47311-47319
    • Shen, K.1
  • 100
    • 0038662654 scopus 로고    scopus 로고
    • Crystal structure of PTP1B complexed with a potent and selective bidentate inhibitor
    • J.P. Sun, and et al. Crystal structure of PTP1B complexed with a potent and selective bidentate inhibitor J. Biol. Chem. 278 2003 12406 12414
    • (2003) J. Biol. Chem. , vol.278 , pp. 12406-12414
    • Sun, J.P.1
  • 101
    • 10744223631 scopus 로고    scopus 로고
    • Cellular effects of small molecule PTP1B inhibitors on insulin signaling
    • L. Xie, and et al. Cellular effects of small molecule PTP1B inhibitors on insulin signaling Biochemistry 42 2003 12792 12804
    • (2003) Biochemistry , vol.42 , pp. 12792-12804
    • Xie, L.1
  • 102
    • 33845882537 scopus 로고    scopus 로고
    • Increased hypothalamic protein tyrosine phosphatase 1B contributes to leptin resistance with age
    • C.D. Morrison, and et al. Increased hypothalamic protein tyrosine phosphatase 1B contributes to leptin resistance with age Endocrinology 148 2007 433 440
    • (2007) Endocrinology , vol.148 , pp. 433-440
    • Morrison, C.D.1
  • 103
    • 33745658606 scopus 로고    scopus 로고
    • Potent benzimidazole sulfonamide protein tyrosine phosphatase 1B inhibitors containing the heterocyclic (S)-isothiazolidinone phosphotyrosine mimetic
    • A.P. Combs, and et al. Potent benzimidazole sulfonamide protein tyrosine phosphatase 1B inhibitors containing the heterocyclic (S)-isothiazolidinone phosphotyrosine mimetic J. Med. Chem. 49 2006 3774 3789
    • (2006) J. Med. Chem. , vol.49 , pp. 3774-3789
    • Combs, A.P.1
  • 104
    • 77955556712 scopus 로고    scopus 로고
    • Synthesis and evaluation of some novel dibenzo[b,d]furan carboxylic acids as potential anti-diabetic agents
    • N. Lakshminarayana, and et al. Synthesis and evaluation of some novel dibenzo[b,d]furan carboxylic acids as potential anti-diabetic agents Eur. J. Med. Chem. 45 2010 3709 3718
    • (2010) Eur. J. Med. Chem. , vol.45 , pp. 3709-3718
    • Lakshminarayana, N.1
  • 105
    • 77954378714 scopus 로고    scopus 로고
    • Pharmacological profiles of a novel protein tyrosine phosphatase 1B inhibitor, JTT-551
    • S. Fukuda, and et al. Pharmacological profiles of a novel protein tyrosine phosphatase 1B inhibitor, JTT-551 Diabetes Obes. Metab. 12 2010 299 306
    • (2010) Diabetes Obes. Metab. , vol.12 , pp. 299-306
    • Fukuda, S.1
  • 106
    • 0027464725 scopus 로고
    • Squalamine: An aminosterol antibiotic from the shark
    • K.S. Moore, and et al. Squalamine: an aminosterol antibiotic from the shark Proc. Natl. Acad. Sci. U.S.A. 90 1993 1354 1358
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 1354-1358
    • Moore, K.S.1
  • 107
    • 0034043334 scopus 로고    scopus 로고
    • Aminosterols from the dogfish shark Squalus acanthias
    • M.N. Rao, and et al. Aminosterols from the dogfish shark Squalus acanthias J. Nat. Prod. 63 2000 631 635
    • (2000) J. Nat. Prod. , vol.63 , pp. 631-635
    • Rao, M.N.1
  • 108
    • 0035021763 scopus 로고    scopus 로고
    • A spermine-coupled cholesterol metabolite from the shark with potent appetite suppressant and antidiabetic properties
    • M. Zasloff, and et al. A spermine-coupled cholesterol metabolite from the shark with potent appetite suppressant and antidiabetic properties Int. J. Obes. Relat. Metab. Disord. 25 2001 689 697
    • (2001) Int. J. Obes. Relat. Metab. Disord. , vol.25 , pp. 689-697
    • Zasloff, M.1
  • 109
    • 0036300139 scopus 로고    scopus 로고
    • Appetite suppression and weight reduction by a centrally active aminosterol
    • R.S. Ahima, and et al. Appetite suppression and weight reduction by a centrally active aminosterol Diabetes 51 2002 2099 2104
    • (2002) Diabetes , vol.51 , pp. 2099-2104
    • Ahima, R.S.1
  • 110
    • 33847202286 scopus 로고    scopus 로고
    • Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis
    • S.G. Julien, and et al. Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis Nat. Genet. 39 2007 338 346
    • (2007) Nat. Genet. , vol.39 , pp. 338-346
    • Julien, S.G.1
  • 111
    • 70349128189 scopus 로고    scopus 로고
    • Acquisition of a potent and selective TC-PTP inhibitor via a stepwise fluorophore-tagged combinatorial synthesis and screening strategy
    • S. Zhang, and et al. Acquisition of a potent and selective TC-PTP inhibitor via a stepwise fluorophore-tagged combinatorial synthesis and screening strategy J. Am. Chem. Soc. 131 2009 13072 13079
    • (2009) J. Am. Chem. Soc. , vol.131 , pp. 13072-13079
    • Zhang, S.1
  • 112
    • 0030769147 scopus 로고    scopus 로고
    • Impaired bone marrow microenvironment and immune function in T cell protein tyrosine phosphatase-deficient mice
    • K.E. You-Ten, and et al. Impaired bone marrow microenvironment and immune function in T cell protein tyrosine phosphatase-deficient mice J. Exp. Med. 186 1997 683 693
    • (1997) J. Exp. Med. , vol.186 , pp. 683-693
    • You-Ten, K.E.1
  • 113
    • 84892992901 scopus 로고    scopus 로고
    • PTPN2 attenuates T-cell lymphopenia-induced proliferation
    • F. Wiede, and et al. PTPN2 attenuates T-cell lymphopenia-induced proliferation Nat. Commun. 5 2014 3073
    • (2014) Nat. Commun. , vol.5 , pp. 3073
    • Wiede, F.1
  • 114
    • 84926420809 scopus 로고    scopus 로고
    • PTPN2 restrains CD8(+) T cell responses after antigen cross-presentation for the maintenance of peripheral tolerance in mice
    • F. Wiede, and et al. PTPN2 restrains CD8(+) T cell responses after antigen cross-presentation for the maintenance of peripheral tolerance in mice J. Autoimmun. 53 2014 105 114
    • (2014) J. Autoimmun. , vol.53 , pp. 105-114
    • Wiede, F.1
  • 115
    • 84055191068 scopus 로고    scopus 로고
    • T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice
    • F. Wiede, and et al. T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice J. Clin. Invest. 121 2011 4758 4774
    • (2011) J. Clin. Invest. , vol.121 , pp. 4758-4774
    • Wiede, F.1
  • 116
    • 85047698627 scopus 로고    scopus 로고
    • Sniffing neuropeptides: A transnasal approach to the human brain
    • J. Born, and et al. Sniffing neuropeptides: a transnasal approach to the human brain Nat. Neurosci. 5 2002 514 516
    • (2002) Nat. Neurosci. , vol.5 , pp. 514-516
    • Born, J.1
  • 117
    • 84872759784 scopus 로고    scopus 로고
    • Protein tyrosine phosphatases: From housekeeping enzymes to master regulators of signal transduction
    • N.K. Tonks Protein tyrosine phosphatases: from housekeeping enzymes to master regulators of signal transduction FEBS J. 280 2013 346 378
    • (2013) FEBS J. , vol.280 , pp. 346-378
    • Tonks, N.K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.