-
2
-
-
7944231534
-
Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation
-
DOI 10.1038/sj.onc.1208074
-
Palacios EH, Weiss A. Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation. Oncogene. 2004;23(48):7990-8000. (Pubitemid 39468856)
-
(2004)
Oncogene
, vol.23
, Issue.48 REV. ISS. 7
, pp. 7990-8000
-
-
Palacios, E.H.1
Weiss, A.2
-
3
-
-
61849128182
-
T-cell receptor proximal signaling via the Src-family kinases, Lck and Fyn, influences T-cell activation, differentiation, and tolerance
-
Salmond RJ, Filby A, Qureshi I, Caserta S, Zamoyska R. T-cell receptor proximal signaling via the Src-family kinases, Lck and Fyn, influences T-cell activation, differentiation, and tolerance. Immunol Rev. 2009;228(1):9-22.
-
(2009)
Immunol Rev
, vol.228
, Issue.1
, pp. 9-22
-
-
Salmond, R.J.1
Filby, A.2
Qureshi, I.3
Caserta, S.4
Zamoyska, R.5
-
4
-
-
61349149901
-
Affinity threshold for thymic selection through a T-cell receptor-co-receptor zipper
-
Palmer E, Naeher D. Affinity threshold for thymic selection through a T-cell receptor-co-receptor zipper. Nat Rev Immunol. 2009;9(3):207-213.
-
(2009)
Nat Rev Immunol
, vol.9
, Issue.3
, pp. 207-213
-
-
Palmer, E.1
Naeher, D.2
-
5
-
-
10744227843
-
Interplay between TCR Affinity and Necessity of Coreceptor Ligation: High-Afinity Peptide-MHC/TCR Interaction Overcomes Lack of CD8 Engagement
-
Kerry SE, et al. Interplay between TCR affinity and necessity of coreceptor ligation: high-affinity peptide- MHC/TCR interaction overcomes lack of CD8 engagement. J Immunol. 2003;171(9):4493-4503. (Pubitemid 37310564)
-
(2003)
Journal of Immunology
, vol.171
, Issue.9
, pp. 4493-4503
-
-
Kerry, S.E.1
Buslepp, J.2
Cramer, L.A.3
Maile, R.4
Hensley, L.L.5
Nielsen, A.I.6
Kavathas, P.7
Vilen, B.J.8
Collins, E.J.9
Frelinger, J.A.10
-
6
-
-
0026522204
-
Profound block in thymocyte development in mice lacking p56lck
-
Molina TJ, et al. Profound block in thymocyte development in mice lacking p56lck. Nature. 1992;357(6374):161-164.
-
(1992)
Nature
, vol.357
, Issue.6374
, pp. 161-164
-
-
Molina, T.J.1
-
7
-
-
33750823918
-
+ T cell responses
-
DOI 10.1073/pnas.0602565103
-
Tewari K, Walent J, Svaren J, Zamoyska R, Suresh M. Differential requirement for Lck during primary and memory CD8+ T cell responses. Proc Natl Acad Sci U S A. 2006;103(44):16388-16393. (Pubitemid 44715206)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.44
, pp. 16388-16393
-
-
Tewari, K.1
Walent, J.2
Svaren, J.3
Zamoyska, R.4
Suresh, M.5
-
8
-
-
33750986199
-
Lck regulates the threshold of activation in primary T cells, while both Lck and Fyn contribute to the magnitude of the extracellular signal-related kinase response
-
DOI 10.1128/MCB.00168-06
-
Lovatt M, Filby A, Parravicini V, Werlen G, Palmer E, Zamoyska R. Lck regulates the threshold of activation in primary T cells, while both Lck and Fyn contribute to the magnitude of the extracellular signal-related kinase response. Mol Cell Biol. 2006;26(22):8655-8665. (Pubitemid 44748595)
-
(2006)
Molecular and Cellular Biology
, vol.26
, Issue.22
, pp. 8655-8665
-
-
Lovatt, M.1
Filby, A.2
Parravicini, V.3
Werlen, G.4
Palmer, E.5
Zamoyska, R.6
-
9
-
-
0034613251
-
Long-term survival but impaired homeostatic proliferation of Naive T cells in the absence of p56lck
-
Seddon B, Legname G, Tomlinson P, Zamoyska R. Long-term survival but impaired homeostatic proliferation of Naive T cells in the absence of p56lck. Science. 2000;290(5489):127-131.
-
(2000)
Science
, vol.290
, Issue.5489
, pp. 127-131
-
-
Seddon, B.1
Legname, G.2
Tomlinson, P.3
Zamoyska, R.4
-
10
-
-
25844526684
-
Central tolerance: Learning self-control in the thymus
-
DOI 10.1038/nri1707
-
Hogquist KA, Baldwin TA, Jameson SC. Central tolerance: learning self-control in the thymus. Nat Rev Immunol. 2005;5(10):772-782. (Pubitemid 41400851)
-
(2005)
Nature Reviews Immunology
, vol.5
, Issue.10
, pp. 772-782
-
-
Hogquist, K.A.1
Baldwin, T.A.2
Jameson, S.C.3
-
11
-
-
33845607123
-
Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling
-
DOI 10.1038/nature05269, PII NATURE05269
-
Daniels MA, et al. Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling. Nature. 2006;444(7120):724-729. (Pubitemid 44949596)
-
(2006)
Nature
, vol.444
, Issue.7120
, pp. 724-729
-
-
Daniels, M.A.1
Teixeiro, E.2
Gill, J.3
Hausmann, B.4
Roubaty, D.5
Holmberg, K.6
Werlen, G.7
Hollander, G.A.8
Gascoigne, N.R.J.9
Palmer, E.10
-
12
-
-
70349751653
-
The strength of T cell receptor signal controls the polarization of cytotoxic machinery to the immunological synapse
-
Jenkins MR, Tsun A, Stinchcombe JC, Griffiths GM. The strength of T cell receptor signal controls the polarization of cytotoxic machinery to the immunological synapse. Immunity. 2009;31(4):621-631.
-
(2009)
Immunity
, vol.31
, Issue.4
, pp. 621-631
-
-
Jenkins, M.R.1
Tsun, A.2
Stinchcombe, J.C.3
Griffiths, G.M.4
-
13
-
-
0037385715
-
T cell fitness determined by signal strength
-
DOI 10.1038/ni908
-
Gett AV, Sallusto F, Lanzavecchia A, Geginat J. T cell fitness determined by signal strength. Nat Immunol. 2003;4(4):355-360. (Pubitemid 36432318)
-
(2003)
Nature Immunology
, vol.4
, Issue.4
, pp. 355-360
-
-
Gett, A.V.1
Sallusto, F.2
Lanzavecchia, A.3
Geginat, J.4
-
14
-
-
62249131518
-
Complete but curtailed T-cell response to very low-affinity antigen
-
Zehn D, Lee SY, Bevan MJ. Complete but curtailed T-cell response to very low-affinity antigen. Nature. 2009;458(7235):211-214.
-
(2009)
Nature
, vol.458
, Issue.7235
, pp. 211-214
-
-
Zehn, D.1
Lee, S.Y.2
Bevan, M.J.3
-
15
-
-
0034903068
-
The Impact of duration versus extent of TCR occupancy on T cell activation: A revision of the kinetic proofreading model
-
DOI 10.1016/S1074-7613(01)00173-X
-
Rosette C, et al. The impact of duration versus extent of TCR occupancy on T cell activation: a revision of the kinetic proofreading model. Immunity. 2001;15(1):59-70. (Pubitemid 32728320)
-
(2001)
Immunity
, vol.15
, Issue.1
, pp. 59-70
-
-
Rosette, C.1
Werlen, G.2
Daniels, M.A.3
Holman, P.O.4
Alam, S.M.5
Travers, P.J.6
Gascoigne, N.R.J.7
Palmer, E.8
Jameson, S.C.9
-
16
-
-
76949085272
-
Dependence of T cell antigen recognition on T cell receptor-peptide MHC confinement time
-
Aleksic M, et al. Dependence of T cell antigen recognition on T cell receptor-peptide MHC confinement time. Immunity. 2010;32(2):163-174.
-
(2010)
Immunity
, vol.32
, Issue.2
, pp. 163-174
-
-
Aleksic, M.1
-
17
-
-
41949097030
-
The biology of interleukin-2
-
DOI 10.1146/annurev.immunol.26.021607.090357
-
Malek TR. The biology of interleukin-2. Annu Rev Immunol. 2008;26:453-479. (Pubitemid 351600382)
-
(2008)
Annual Review of Immunology
, vol.26
, pp. 453-479
-
-
Malek, T.R.1
-
18
-
-
0024416009
-
Evidence that the leukocyte-common antigen is required for antigen-induced T lymphocyte proliferation
-
DOI 10.1016/0092-8674(89)90504-7
-
Pingel JT, Thomas ML. Evidence that the leukocyte- common antigen is required for antigeninduced T lymphocyte proliferation. Cell. 1989; 58(6):1055-1065. (Pubitemid 19238183)
-
(1989)
Cell
, vol.58
, Issue.6
, pp. 1055-1065
-
-
Pingel, J.T.1
Thomas, M.L.2
-
19
-
-
0025297050
-
Tyrosine phosphatase CD45 is essential for coupling T-cell antigen receptor to the phosphatidyl inositol pathway
-
Koretzky GA, Picus J, Thomas ML, Weiss A. Tyrosine phosphatase CD45 is essential for coupling T-cell antigen receptor to the phosphatidyl inositol pathway. Nature. 1990;346(6279):66-68.
-
(1990)
Nature
, vol.346
, Issue.6279
, pp. 66-68
-
-
Koretzky, G.A.1
Picus, J.2
Thomas, M.L.3
Weiss, A.4
-
21
-
-
34548679868
-
The Differential Regulation of Lck Kinase Phosphorylation Sites by CD45 Is Critical for T Cell Receptor Signaling Responses
-
DOI 10.1016/j.immuni.2007.07.015, PII S1074761307003810
-
McNeill L, et al. The differential regulation of Lck kinase phosphorylation sites by CD45 is critical for T cell receptor signaling responses. Immunity. 2007;27(3):425-437. (Pubitemid 47418669)
-
(2007)
Immunity
, vol.27
, Issue.3
, pp. 425-437
-
-
McNeill, L.1
Salmond, R.J.2
Cooper, J.C.3
Carret, C.K.4
Cassady-Cain, R.L.5
Roche-Molina, M.6
Tandon, P.7
Holmes, N.8
Alexander, D.R.9
-
22
-
-
0033558102
-
Cutting edge: The CD45 tyrosine phosphatase is an inhibitor of Lck activity in thymocytes
-
D'Oro U, Ashwell JD. Cutting edge: the CD45 tyrosine phosphatase is an inhibitor of Lck activity in thymocytes. J Immunol. 1999;162(4):1879-1883. (Pubitemid 29288800)
-
(1999)
Journal of Immunology
, vol.162
, Issue.4
, pp. 1879-1883
-
-
D'Oro, U.1
Ashwell, J.D.2
-
23
-
-
77949962019
-
CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development
-
Zikherman J, et al. CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development. Immunity. 2010;32(3):342-354.
-
(2010)
Immunity
, vol.32
, Issue.3
, pp. 342-354
-
-
Zikherman, J.1
-
24
-
-
0037338890
-
TCR ligand discrimination is enforced by competing ERK positive and SHP-I negative feedback pathways
-
DOI 10.1038/ni895
-
Stefanova I, Hemmer B, Vergelli M, Martin R, Biddison WE, Germain RN. TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways. Nat Immunol. 2003;4(3):248-254. (Pubitemid 36322134)
-
(2003)
Nature Immunology
, vol.4
, Issue.3
, pp. 248-254
-
-
Stefanova, I.1
Hemmer, B.2
Vergelli, M.3
Martin, R.4
Biddison, W.E.5
Germain, R.N.6
-
25
-
-
0035933771
-
Specific dephosphorylation of the Lck tyrosine protein kinase at Tyr-394 by the SHP-1 protein-tyrosine phosphatase
-
Chiang GG, Sefton BM. Specific dephosphorylation of the Lck tyrosine protein kinase at Tyr-394 by the SHP-1 protein-tyrosine phosphatase. J Biol Chem. 2001;276(25):23173-23178.
-
(2001)
J Biol Chem
, vol.276
, Issue.25
, pp. 23173-23178
-
-
Chiang, G.G.1
Sefton, B.M.2
-
26
-
-
0029904138
-
Direct regulation of ZAP-70 by SHP-1 in T cell antigen receptor signaling
-
Plas DR, et al. Direct regulation of ZAP-70 by SHP-1 in T cell antigen receptor signaling. Science. 1996;272(5265):1173-1176. (Pubitemid 26169472)
-
(1996)
Science
, vol.272
, Issue.5265
, pp. 1173-1176
-
-
Plas, D.R.1
Johnson, R.2
Pingel, J.T.3
Matthews, R.J.4
Dalton, M.5
Roy, G.6
Chan, A.C.7
Thomas, M.L.8
-
27
-
-
0034948374
-
Involvement of SHP-1 tyrosine phosphatase in TCR-Mediated signaling pathways in lipid rafts
-
DOI 10.1016/S1074-7613(01)00146-7
-
Kosugi A, Sakakura J, Yasuda K, Ogata M, Hamaoka T. Involvement of SHP-1 tyrosine phosphatase in TCR-mediated signaling pathways in lipid rafts. Immunity. 2001;14(6):669-680. (Pubitemid 32592415)
-
(2001)
Immunity
, vol.14
, Issue.6
, pp. 669-680
-
-
Kosugi, A.1
Sakakura, J.2
Yasuda, K.3
Ogata, M.4
Hamaoka, T.5
-
28
-
-
0242712698
-
Characterization of TCR-induced receptor-proximal signaling events negatively regulated by the protein tyrosine phosphatase PEP
-
Gjorloff-Wingren A, Saxena M, Williams S, Hammi D, Mustelin T. Characterization of TCR-induced receptor-proximal signaling events negatively regulated by the protein tyrosine phosphatase PEP. Eur J Immunol. 1999;29(12):3845-3854.
-
(1999)
Eur J Immunol
, vol.29
, Issue.12
, pp. 3845-3854
-
-
Gjorloff-Wingren, A.1
Saxena, M.2
Williams, S.3
Hammi, D.4
Mustelin, T.5
-
29
-
-
0942279640
-
PEST Domain-Enriched Tyrosine Phosphatase (PEP) Regulation of Effector/Memory T Cells
-
DOI 10.1126/science.1092138
-
Hasegawa K, Martin F, Huang G, Tumas D, Diehl L, Chan AC. PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells. Science. 2004;303(5658):685-689. (Pubitemid 38141637)
-
(2004)
Science
, vol.303
, Issue.5658
, pp. 685-689
-
-
Hasegawa, K.1
Martin, F.2
Huang, G.3
Tumas, D.4
Diehl, L.5
Chan, A.C.6
-
30
-
-
0034064779
-
Mutations in the tyrosine phosphatase CD45 gene in a child with severe combined immunodeficiency disease
-
DOI 10.1038/73208
-
Kung C, et al. Mutations in the tyrosine phosphatase CD45 gene in a child with severe combined immunodeficiency disease. Nat Med. 2000;6(3):343-345. (Pubitemid 30148629)
-
(2000)
Nature Medicine
, vol.6
, Issue.3
, pp. 343-345
-
-
Kung, C.1
Pingel, J.T.2
Heikinheimo, M.3
Klemola, T.4
Varkila, K.5
Yoo, L.I.6
Vuopala, K.7
Poyhonen, M.8
Uhari, M.9
Rogers, M.10
Speck, S.H.11
Chatila, T.12
Thomas, M.L.13
-
31
-
-
0035863892
-
A deletion in the gene encoding the CD45 antigen in a patient with SCID
-
Tchilian EZ, Wallace DL, Wells RS, Flower DR, Morgan G, Beverley PC. A deletion in the gene encoding the CD45 antigen in a patient with SCID. J Immunol. 2001;166(2):1308-1313. (Pubitemid 32060292)
-
(2001)
Journal of Immunology
, vol.166
, Issue.2
, pp. 1308-1313
-
-
Tchilian, E.Z.1
Wallace, D.L.2
Wells, R.S.3
Flower, D.R.4
Morgan, G.5
Beverley, P.C.L.6
-
32
-
-
33745169029
-
Role of PTPN22 in type 1 diabetes and other autoimmune diseases
-
DOI 10.1016/j.smim.2006.03.008, PII S1044532306000455
-
Bottini N, Vang T, Cucca F, Mustelin T. Role of PTPN22 in type 1 diabetes and other autoimmune diseases. Semin Immunol. 2006;18(4):207-213. (Pubitemid 43903283)
-
(2006)
Seminars in Immunology
, vol.18
, Issue.4
, pp. 207-213
-
-
Bottini, N.1
Vang, T.2
Cucca, F.3
Mustelin, T.4
-
33
-
-
34347341846
-
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes
-
DOI 10.1038/ng2068, PII NG2068
-
Todd JA, et al. Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat Genet. 2007;39(7):857-864. (Pubitemid 47018195)
-
(2007)
Nature Genetics
, vol.39
, Issue.7
, pp. 857-864
-
-
Todd, J.A.1
Walker, N.M.2
Cooper, J.D.3
Smyth, D.J.4
Downes, K.5
Plagnol, V.6
Bailey, R.7
Nejentsev, S.8
Field, S.F.9
Payne, F.10
Lowe, C.E.11
Szeszko, J.S.12
Hafler, J.P.13
Zeitels, L.14
Yang, J.H.M.15
Vella, A.16
Nutland, S.17
Stevens, H.E.18
Schuilenburg, H.19
Coleman, G.20
Maisuria, M.21
Meadows, W.22
Smink, L.J.23
Healy, B.24
Burren, O.S.25
Lam, A.A.C.26
Ovington, N.R.27
Allen, J.28
Adlem, E.29
Leung, H.-T.30
Wallace, C.31
Howson, J.M.M.32
Guja, C.33
Ionescu-Tirgoviste, C.34
Simmonds, M.J.35
Heward, J.M.36
Gough, S.C.L.37
Dunger, D.B.38
Wicker, L.S.39
Clayton, D.G.40
more..
-
34
-
-
58149091678
-
Shared and distinct genetic variants in type 1 diabetes and celiac disease
-
Smyth DJ, et al. Shared and distinct genetic variants in type 1 diabetes and celiac disease. N Engl J Med. 2008;359(26):2767-2777.
-
(2008)
N Engl J Med
, vol.359
, Issue.26
, pp. 2767-2777
-
-
Smyth, D.J.1
-
35
-
-
84969213492
-
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
-
WTCCC
-
WTCCC. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature. 2007;447(7145):661-678.
-
(2007)
Nature
, vol.447
, Issue.7145
, pp. 661-678
-
-
-
36
-
-
79952280031
-
An autoimmune-associated variant in PTPN2 reveals an impairment of IL-2R signaling in CD4(+) T cells
-
Long SA, et al. An autoimmune-associated variant in PTPN2 reveals an impairment of IL-2R signaling in CD4(+) T cells. Genes Immun. 2011;12(2):116-125.
-
(2011)
Genes Immun
, vol.12
, Issue.2
, pp. 116-125
-
-
Long, S.A.1
-
37
-
-
77952887619
-
Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia
-
Kleppe M, et al. Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia. Nat Genet. 2010;42(6):530-535.
-
(2010)
Nat Genet
, vol.42
, Issue.6
, pp. 530-535
-
-
Kleppe, M.1
-
38
-
-
0030769147
-
Impaired bone marrow microenvironment and immune function in T cell protein tyrosine phosphatase-deficient mice
-
DOI 10.1084/jem.186.5.683
-
You-Ten KE, et al. Impaired bone marrow microenvironment and immune function in T cell protein tyrosine phosphatase-deficient mice. J Exp Med. 1997;186(5):683-693. (Pubitemid 27381533)
-
(1997)
Journal of Experimental Medicine
, vol.186
, Issue.5
, pp. 683-693
-
-
You-Ten, K.E.1
Muise, E.S.2
Itie, A.3
Michaliszyn, E.4
Wagner, J.5
Jothy, S.6
Lapp, W.S.7
Tremblay, M.L.8
-
39
-
-
1942489307
-
T-cell protein tyrosine phosphatase deletion results in progressive systemic inflammatory disease
-
DOI 10.1182/blood-2003-09-3153
-
Heinonen KM, et al. T-cell protein tyrosine phosphatase deletion results in progressive systemic inf lammatory disease. Blood. 2004; 103(9):3457-3464. (Pubitemid 38525678)
-
(2004)
Blood
, vol.103
, Issue.9
, pp. 3457-3464
-
-
Heinonen, K.M.1
Nestel, F.P.2
Newell, E.W.3
Charette, G.4
Seemayer, T.A.5
Tremblay, M.L.6
Lapp, W.S.7
-
40
-
-
0029556979
-
T-cell-specific deletion of a polypeptide N-acetylgalactosaminyl- transferase gene by site-directed recombination
-
Hennet T, Hagen FK, Tabak LA, Marth JD. T-cell-specific deletion of a polypeptide N-acetylgalactosaminyl- transferase gene by site-directed recombination. Proc Natl Acad Sci U S A. 1995;92(26):12070-12074.
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, Issue.26
, pp. 12070-12074
-
-
Hennet, T.1
Hagen, F.K.2
Tabak, L.A.3
Marth, J.D.4
-
41
-
-
0028059099
-
Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting
-
Gu H, Marth JD, Orban PC, Mossmann H, Rajewsky K. Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting. Science. 1994;265(5168):103-106.
-
(1994)
Science
, vol.265
, Issue.5168
, pp. 103-106
-
-
Gu, H.1
Marth, J.D.2
Orban, P.C.3
Mossmann, H.4
Rajewsky, K.5
-
42
-
-
38749094821
-
Development of all CD4 T lineages requires nuclear factor TOX
-
DOI 10.1084/jem.20071944
-
Aliahmad P, Kaye J. Development of all CD4 T lineages requires nuclear factor TOX. J Exp Med. 2008;205(1):245-256. (Pubitemid 351185730)
-
(2008)
Journal of Experimental Medicine
, vol.205
, Issue.1
, pp. 245-256
-
-
Aliahmad, P.1
Kaye, J.2
-
43
-
-
0028178784
-
T cell receptor antagonist peptides induce positive selection
-
DOI 10.1016/0092-8674(94)90169-4
-
Hogquist KA, Jameson SC, Heath WR, Howard JL, Bevan MJ, Carbone FR. T cell receptor antagonist peptides induce positive selection. Cell. 1994;76(1):17-27. (Pubitemid 24035278)
-
(1994)
Cell
, vol.76
, Issue.1
, pp. 17-27
-
-
Hogquist, K.A.1
Jameson, S.C.2
Heath, W.R.3
Howard, J.L.4
Bevan, M.J.5
Carbone, F.R.6
-
44
-
-
0031897801
-
Defective TCR expression in transgenic mice constructed using cDNA- based alpha- and beta-chain genes under the control of heterologous regulatory elements
-
DOI 10.1046/j.1440-1711.1998.00709.x
-
Barnden MJ, Allison J, Heath WR, Carbone FR. Defective TCR expression in transgenic mice constructed using cDNA-based alpha- and beta-chain genes under the control of heterologous regulatory elements. Immunol Cell Biol. 1998;76(1):34-40. (Pubitemid 28194695)
-
(1998)
Immunology and Cell Biology
, vol.76
, Issue.1
, pp. 34-40
-
-
Barnden, M.J.1
Allison, J.2
Heath, W.R.3
Carbone, F.R.4
-
45
-
-
0025022278
-
Requirement for cotolerogenic gene products in the clonal deletion of I-E reactive T cells
-
Woodland D, Happ MP, Bill J, Palmer E. Requirement for cotolerogenic gene products in the clonal deletion of I-E reactive T cells. Science. 1990;247(4945):964-967.
-
(1990)
Science
, vol.247
, Issue.4945
, pp. 964-967
-
-
Woodland, D.1
Happ, M.P.2
Bill, J.3
Palmer, E.4
-
46
-
-
0026453632
-
Both intrathymic and peripheral selection modulate the differential expression of V beta 5 among CD4+ and CD8+ T cells
-
Fink PJ, Swan K, Turk G, Moore MW, Carbone FR. Both intrathymic and peripheral selection modulate the differential expression of V beta 5 among CD4+ and CD8+ T cells. J Exp Med. 1992; 176(6):1733-1738.
-
(1992)
J Exp Med
, vol.176
, Issue.6
, pp. 1733-1738
-
-
Fink, P.J.1
Swan, K.2
Turk, G.3
Moore, M.W.4
Carbone, F.R.5
-
47
-
-
0028807837
-
A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection
-
Calnan BJ, Szychowski S, Chan FK, Cado D, Winoto A. A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection. Immunity. 1995;3(3):273-282.
-
(1995)
Immunity
, vol.3
, Issue.3
, pp. 273-282
-
-
Calnan, B.J.1
Szychowski, S.2
Chan, F.K.3
Cado, D.4
Winoto, A.5
-
48
-
-
14944349510
-
Selective regulation of tumor necrosis factor-induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphatase
-
van Vliet C, et al. Selective regulation of tumor necrosis factor-induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphatase. Nat Immunol. 2005;6(3):253-260.
-
(2005)
Nat Immunol
, vol.6
, Issue.3
, pp. 253-260
-
-
Van Vliet, C.1
-
49
-
-
0031055324
-
Development of "substrate-trapping" mutants to identify physiological substrates of protein tyrosine phosphatases
-
Flint AJ, Tiganis T, Barford D, Tonks NK. Development of "substrate-trapping" mutants to identify physiological substrates of protein tyrosine phosphatases. Proc Natl Acad Sci U S A. 1997;94(5):1680-1685.
-
(1997)
Proc Natl Acad Sci U S A
, vol.94
, Issue.5
, pp. 1680-1685
-
-
Flint, A.J.1
Tiganis, T.2
Barford, D.3
Tonks, N.K.4
-
50
-
-
0031935043
-
Epidermal growth factor receptor and the adaptor protein p52(Shc) are specific substrates of T-cell protein tyrosine phosphatase
-
Tiganis T, Bennett AM, Ravichandran KS, Tonks NK. Epidermal growth factor receptor and the adaptor protein p52Shc are specific substrates of T-cell protein tyrosine phosphatase. Mol Cell Biol. 1998;18(3):1622-1634. (Pubitemid 28100928)
-
(1998)
Molecular and Cellular Biology
, vol.18
, Issue.3
, pp. 1622-1634
-
-
Tiganis, T.1
Bennett, A.M.2
Ravichandran, K.S.3
Tonks, N.K.4
-
51
-
-
33846945811
-
Protein tyrosine phosphatase function: The substrate perspective
-
Tiganis T, Bennett AM. Protein tyrosine phosphatase function: the substrate perspective. Biochem J. 2007;402(1):1-15.
-
(2007)
Biochem J
, vol.402
, Issue.1
, pp. 1-15
-
-
Tiganis, T.1
Bennett, A.M.2
-
52
-
-
61849166005
-
The structure, regulation, and function of ZAP-70
-
Au-Yeung BB, et al. The structure, regulation, and function of ZAP-70. Immunol Rev. 2009;228(1):41-57.
-
(2009)
Immunol Rev
, vol.228
, Issue.1
, pp. 41-57
-
-
Au-Yeung, B.B.1
-
54
-
-
0026705903
-
Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor
-
Straus DB, Weiss A. Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor. Cell. 1992;70(4):585-593.
-
(1992)
Cell
, vol.70
, Issue.4
, pp. 585-593
-
-
Straus, D.B.1
Weiss, A.2
-
55
-
-
0029844309
-
Lack of SHPTP1 results in src-family kinase hyperactivation and thymocyte hyperresponsiveness
-
DOI 10.1073/pnas.93.18.9624
-
Lorenz U, Ravichandran KS, Burakoff SJ, Neel BG. Lack of SHPTP1 results in src-family kinase hyperactivation and thymocyte hyperresponsiveness. Proc Natl Acad Sci U S A. 1996;93(18):9624-9629. (Pubitemid 26296658)
-
(1996)
Proceedings of the National Academy of Sciences of the United States of America
, vol.93
, Issue.18
, pp. 9624-9629
-
-
Lorenz, U.1
Ravichandran, K.S.2
Burakoff, S.J.3
Neel, B.G.4
-
56
-
-
0028108177
-
Peptide antagonists that promote positive selection are inefficient at T cell activation and thymocyte deletion
-
DOI 10.1002/eji.1830241029
-
Barnden MJ, Heath WR, Rodda S, Carbone FR. Peptide antagonists that promote positive selection are inefficient at T cell activation and thymocyte deletion. Eur J Immunol. 1994;24(10):2452-2456. (Pubitemid 24303092)
-
(1994)
European Journal of Immunology
, vol.24
, Issue.10
, pp. 2452-2456
-
-
Barnden, M.J.1
Heath, W.R.2
Rodda, S.3
Carbone, F.R.4
-
57
-
-
0037108981
-
+ T cells through transfer of the peptide to T cell MHC molecules
-
DOI 10.1073/pnas.212515299
-
Ge Q, et al. Soluble peptide-MHC monomers cause activation of CD8+ T cells through transfer of the peptide to T cell MHC molecules. Proc Natl Acad Sci U S A. 2002;99(21):13729-13734. (Pubitemid 35215449)
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, Issue.21
, pp. 13729-13734
-
-
Ge, Q.1
Stone, J.D.2
Thompson, M.T.3
Cochran, J.R.4
Rushe, M.5
Eisen, H.N.6
Chen, J.7
Stern, L.J.8
-
58
-
-
34848812557
-
TCR affinity promotes CD8+ T cell expansion by regulating survival
-
Hommel M, Hodgkin PD. TCR affinity promotes CD8+ T cell expansion by regulating survival. J Immunol. 2007;179(4):2250-2260.
-
(2007)
J Immunol
, vol.179
, Issue.4
, pp. 2250-2260
-
-
Hommel, M.1
Hodgkin, P.D.2
-
59
-
-
75149178563
-
The role of chemokines in the recruitment of lymphocytes to the liver
-
Oo YH, Adams DH. The role of chemokines in the recruitment of lymphocytes to the liver. J Autoimmun. 2010;34(1):45-54.
-
(2010)
J Autoimmun
, vol.34
, Issue.1
, pp. 45-54
-
-
Oo, Y.H.1
Adams, D.H.2
-
60
-
-
41149099559
-
Functional and genomic profiling of effector CD8 T cell subsets with distinct memory fates
-
DOI 10.1084/jem.20071641
-
Sarkar S, Kalia V, Haining WN, Konieczny BT, Subramaniam S, Ahmed R. Functional and genomic profiling of effector CD8 T cell subsets with distinct memory fates. J Exp Med. 2008;205(3):625-640. (Pubitemid 351439309)
-
(2008)
Journal of Experimental Medicine
, vol.205
, Issue.3
, pp. 625-640
-
-
Sarkar, S.1
Kalia, V.2
Haining, W.N.3
Konieczny, B.T.4
Subramaniam, S.5
Ahmed, R.6
-
61
-
-
0033431029
-
The tyrosine phosphatase SHP-1 influences thymocyte selection by setting TCR signaling thresholds
-
Carter JD, Neel BG, Lorenz U. The tyrosine phosphatase SHP-1 influences thymocyte selection by setting TCR signaling thresholds. Int Immunol. 1999;11(12):1999-2014.
-
(1999)
Int Immunol
, vol.11
, Issue.12
, pp. 1999-2014
-
-
Carter, J.D.1
Neel, B.G.2
Lorenz, U.3
-
62
-
-
0037396793
-
+ T cell differentiation
-
DOI 10.1016/S1074-7613(03)00078-5
-
Chong MM, et al. Suppressor of cytokine signaling- 1 is a critical regulator of interleukin-7- dependent CD8+ T cell differentiation. Immunity. 2003;18(4):475-487. (Pubitemid 36513630)
-
(2003)
Immunity
, vol.18
, Issue.4
, pp. 475-487
-
-
Chong, M.M.W.1
Cornish, A.L.2
Darwiche, R.3
Stanley, E.G.4
Purton, J.F.5
Godfrey, D.I.6
Hilton, D.J.7
Starr, R.8
Alexander, W.S.9
Kay, T.W.H.10
-
63
-
-
0036138705
-
A nuclear protein tyrosine phosphatase TC-PTP is a potential negative regulator of the PRL-mediated signaling pathway: Dephosphorylation and deactivation of signal transducer and activator of transcription 5a and 5b by TC-PTP in nucleus
-
DOI 10.1210/me.16.1.58
-
Aoki N, Matsuda T. A nuclear protein tyrosine phosphatase TC-PTP is a potential negative regulator of the PRL-mediated signaling pathway: dephosphorylation and deactivation of signal transducer and activator of transcription 5a and 5b by TC-PTP in nucleus. Mol Endocrinol. 2002; 16(1):58-69. (Pubitemid 34044498)
-
(2002)
Molecular Endocrinology
, vol.16
, Issue.1
, pp. 58-69
-
-
Aoki, N.1
Matsuda, T.2
-
64
-
-
0036006288
-
The T cell protein tyrosine phosphatase is a negative regulator of Janus family kinases 1 and 3
-
DOI 10.1016/S0960-9822(02)00697-8, PII S0960982202006978
-
Simoncic PD, Lee-Loy A, Barber DL, Tremblay ML, McGlade CJ. The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3. Curr Biol. 2002;12(6):446-453. (Pubitemid 34248890)
-
(2002)
Current Biology
, vol.12
, Issue.6
, pp. 446-453
-
-
Simoncic, P.D.1
Lee-Loy, A.2
Barber, D.L.3
Tremblay, M.L.4
McGlade, C.J.5
-
65
-
-
0033625496
-
Inducible expression of a p56Lck transgene reveals a central role for Lck in the differentiation of CD4 SP thymocytes
-
Legname G, et al. Inducible expression of a p56Lck transgene reveals a central role for Lck in the differentiation of CD4 SP thymocytes. Immunity. 2000;12(5):537-546.
-
(2000)
Immunity
, vol.12
, Issue.5
, pp. 537-546
-
-
Legname, G.1
-
66
-
-
0033696201
-
Lck activity controls CD4/CD8 T cell lineage commitment
-
Hernandez-Hoyos G, Sohn SJ, Rothenberg EV, Alberola-Ila J. Lck activity controls CD4/CD8 T cell lineage commitment. Immunity. 2000;12(3):313-322.
-
(2000)
Immunity
, vol.12
, Issue.3
, pp. 313-322
-
-
Hernandez-Hoyos, G.1
Sohn, S.J.2
Rothenberg, E.V.3
Alberola-Ila, J.4
-
67
-
-
57449097558
-
Homeostasis of naive and memory T cells
-
Surh CD, Sprent J. Homeostasis of naive and memory T cells. Immunity. 2008;29(6):848-862.
-
(2008)
Immunity
, vol.29
, Issue.6
, pp. 848-862
-
-
Surh, C.D.1
Sprent, J.2
-
68
-
-
0037460071
-
Involvement of avidity for major histocompatibility complex in homeostasis of naive and memory T cells
-
DOI 10.1084/jem.20021812
-
Kassiotis G, Zamoyska R, Stockinger B. Involvement of avidity for major histocompatibility complex in homeostasis of naive and memory T cells. J Exp Med. 2003;197(8):1007-1016. (Pubitemid 36523198)
-
(2003)
Journal of Experimental Medicine
, vol.197
, Issue.8
, pp. 1007-1016
-
-
Kassiotis, G.1
Zamoyska, R.2
Stockinger, B.3
-
69
-
-
0346103729
-
A Role for TCR Affinity in Regulating Naive T Cell Homeostasis
-
Kieper WC, Burghardt JT, Surh CD. A role for TCR affinity in regulating naive T cell homeostasis. J Immunol. 2004;172(1):40-44. (Pubitemid 38020453)
-
(2004)
Journal of Immunology
, vol.172
, Issue.1
, pp. 40-44
-
-
Kieper, W.C.1
Burghardt, J.T.2
Surh, C.D.3
-
70
-
-
68949166331
-
Lymphocyte proliferation in immune-mediated diseases
-
Datta S, Sarvetnick N. Lymphocyte proliferation in immune-mediated diseases. Trends Immunol. 2009;30(9):430-438.
-
(2009)
Trends Immunol
, vol.30
, Issue.9
, pp. 430-438
-
-
Datta, S.1
Sarvetnick, N.2
-
71
-
-
33947221062
-
T-cell protein tyrosine phosphatase, distinctively expressed in activated-B-cell-like diffuse large B-cell lymphomas, is the nuclear phosphatase of STAT6
-
DOI 10.1128/MCB.01234-06
-
Lu X, et al. T-cell protein tyrosine phosphatase, distinctively expressed in activated-B-cell-like diffuse large B-cell lymphomas, is the nuclear phosphatase of STAT6. Mol Cell Biol. 2007;27(6):2166-2179. (Pubitemid 46418473)
-
(2007)
Molecular and Cellular Biology
, vol.27
, Issue.6
, pp. 2166-2179
-
-
Lu, X.1
Chen, J.2
Sasmono, R.T.3
Hsi, E.D.4
Sarosiek, K.A.5
Tiganis, T.6
Lossos, I.S.7
-
72
-
-
78649869141
-
SHP-1 in T cells limits the production of CD8 effector cells without impacting the formation of long-lived central memory cells
-
Fowler CC, Pao LI, Blattman JN, Greenberg PD. SHP-1 in T cells limits the production of CD8 effector cells without impacting the formation of long-lived central memory cells. J Immunol. 2010;185(6):3256-3267.
-
(2010)
J Immunol
, vol.185
, Issue.6
, pp. 3256-3267
-
-
Fowler, C.C.1
Pao, L.I.2
Blattman, J.N.3
Greenberg, P.D.4
-
73
-
-
0037105615
-
TCR signals mediated by Src family kinases are essential for the survival of naive T cells
-
Seddon B, Zamoyska R. TCR signals mediated by Src family kinases are essential for the survival of naive T cells. J Immunol. 2002;169(6):2997-3005. (Pubitemid 35013142)
-
(2002)
Journal of Immunology
, vol.169
, Issue.6
, pp. 2997-3005
-
-
Seddon, B.1
Zamoyska, R.2
-
74
-
-
49249128709
-
Fyn regulates the duration of TCR engagement needed for commitment to effector function
-
Filby A, et al. Fyn regulates the duration of TCR engagement needed for commitment to effector function. J Immunol. 2007;179(7):4635-4644.
-
(2007)
J Immunol
, vol.179
, Issue.7
, pp. 4635-4644
-
-
Filby, A.1
-
75
-
-
80455122701
-
Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance
-
Loh K, et al. Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance. Cell Metab. 2011;14(5):684-699.
-
(2011)
Cell Metab
, vol.14
, Issue.5
, pp. 684-699
-
-
Loh, K.1
|