Crystal structure of PTP1B complexed with a potent and selective bidentate inhibitor

Journal of Biological Chemistry

Volumn 278, Issue 14, 2003, Pages 12406-12414

  Sun, Jin Peng ^a   Fedorov, Alexander A ^a   Lee, Seung Yub ^a   Guo, Xiao Ling ^a   Shen, Kui ^a,b   Lawrence, David S ^a   Almo, Steven C ^a   Zhang, Zhong Yin ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYST ACTIVITY; CRYSTAL STRUCTURE; DATA REDUCTION; INSULIN; REACTION KINETICS;

PHOSPHATE-BINDING;

ENZYME INHIBITION;

INSULIN; LEPTIN; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE 1B; PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR; UNCLASSIFIED DRUG; 2 MORPHOLINOETHANESULFONIC ACID; 2-(N-MORPHOLINO)ETHANESULFONIC ACID; ALKANESULFONIC ACID; DRUG DERIVATIVE; MORPHOLINE DERIVATIVE; PHENYLALANINE; PHOSPHONODIFLUOROMETHYLPHENYLALANINE; VANADIC ACID;

ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; KINETICS; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; BINDING SITE; CHEMISTRY; CRYSTALLOGRAPHY; GENETICS; HUMAN; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE;

ALKANESULFONIC ACIDS; BINDING SITES; CRYSTALLOGRAPHY; HUMANS; KINETICS; MORPHOLINES; MUTAGENESIS, SITE-DIRECTED; PHENYLALANINE; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTEIN-TYROSINE-PHOSPHATASE; VANADATES;

EID: 0038662654     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M212491200     Document Type: Article

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