Acquisition of a Specific and Potent PTP1B Inhibitor from a Novel Combinatorial Library and Screening Procedure

Journal of Biological Chemistry

Volumn 276, Issue 50, 2001, Pages 47311-47319

  Shen, Kui ^a   Keng, Yen Fang ^a   Wu, Li ^a   Guo, Xiao Ling ^a   Lawrence, David S ^a   Zhang, Zhong Yin ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG PRODUCTS; ENZYME KINETICS; ENZYMES; GENES; TUMORS;

PHOSPHORYLATION;

BIOCHEMISTRY;

CD45 ANTIGEN; PHOSPHOTRANSFERASE; PROTEIN CDC25A; PROTEIN HEPTP; PROTEIN LAR; PROTEIN MKP3; PROTEIN PP2C; PROTEIN STP1; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR; PROTEIN TYROSINE PHOSPHATASE ALPHA; PROTEIN TYROSINE PHOSPHATASE INHIBITOR; PROTEIN TYROSINE PHOSPHATASE SHP 1; PROTEIN TYROSINE PHOSPHATASE SHP 2; PROTEIN VHR; UNCLASSIFIED DRUG; DIPEPTIDE; ENZYME INHIBITOR; GLUTATHIONE TRANSFERASE; HYBRID PROTEIN; LIGAND; N (ALPHA (4 (PHOSPHONODIFLUOROMETHYL)PHENYL)ACETYL)ASPARTYL 4 (PHOSPHONODIFLUOROMETHYL)PHENYLALANINAMIDE; N-(ALPHA-(4-(PHOSPHONODIFLUOROMETHYL)PHENYL)ACETYL)ASPARTYL-4-(PHOSPHONODIFLUOROMETHYL)PHENYLALANINAMIDE; PEPTIDE; PEPTIDE LIBRARY; PTP 1B PROTEIN; PTP-1B PROTEIN;

ARTICLE; BINDING AFFINITY; BINDING SITE; CANCER RISK; COMBINATORIAL LIBRARY; DIABETES MELLITUS; DNA SCREENING; DRUG POTENCY; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; ENZYME SPECIFICITY; INHIBITION KINETICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; YERSINIA; ANIMAL; CHEMICAL MODEL; CHEMISTRY; DRUG DESIGN; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETIC PROCEDURES; IC 50; KINETICS; METABOLISM; MOLECULAR CLONING; MOUSE; PROTEIN BINDING; RABBIT; SYNTHESIS;

YERSINIA;

ANIMAL; BINDING SITES; CLONING, MOLECULAR; DIPEPTIDES; DRUG DESIGN; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENETIC TECHNIQUES; GLUTATHIONE TRANSFERASE; INHIBITORY CONCENTRATION 50; KINETICS; LIGANDS; MICE; MODELS, CHEMICAL; PEPTIDE LIBRARY; PEPTIDES; PROTEIN BINDING; PROTEIN-TYROSINE-PHOSPHATASE; RABBITS; RECOMBINANT FUSION PROTEINS; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0035861668     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M106568200     Document Type: Article

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