메뉴 건너뛰기




Volumn 223, Issue 1, 2014, Pages T25-T35

Connecting leptin signaling to biological function

Author keywords

Hypothalamus; Leptin; Obesity; Signal transduction

Indexed keywords

GLUCOSE; INSULIN RECEPTOR SUBSTRATE; LEPTIN; LEPTIN RECEPTOR; LEPTIN RECEPTOR B; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE SHP 2; SH2B1 PROTEIN; STAT3 PROTEIN; STAT5 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING; SUPPRESSOR OF CYTOKINE SIGNALING 3; TYROSINE; UNCLASSIFIED DRUG;

EID: 84907867610     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1530/JOE-14-0404     Document Type: Review
Times cited : (187)

References (94)
  • 3
    • 0034640508 scopus 로고    scopus 로고
    • Activation of downstream signals by the long form of the leptin receptor
    • Banks AS, Davis SM, Bates SH&Myers MG Jr 2000 Activation of downstream signals by the long form of the leptin receptor. Journal of Biological Chemistry 275 14563-14572. (doi:10.1074/jbc.275.19.14563)
    • (2000) Journal of Biological Chemistry , vol.275 , pp. 14563-14572
    • Banks, A.S.1    Davis, S.M.2    Bates, S.H.3    Myers, M.G.4
  • 5
    • 0345168238 scopus 로고    scopus 로고
    • The role of leptin receptor signaling in feeding and neuroendocrine function
    • Bates SH&Myers MG Jr 2003 The role of leptin receptor signaling in feeding and neuroendocrine function. Trends in Endocrinology and Metabolism 14 447-452. (doi:10.1016/j.tem.2003.10.003)
    • (2003) Trends in Endocrinology and Metabolism , vol.14 , pp. 447-452
    • Bates, S.H.1    Myers, M.G.2
  • 7
    • 9444264702 scopus 로고    scopus 로고
    • LRb-STAT3 signaling is required for the neuroendocrine regulation of energy expenditure by leptin
    • Bates SH, Dundon TA, Seifert M, Carlson M, Maratos-Flier E&Myers MG Jr 2004 LRb-STAT3 signaling is required for the neuroendocrine regulation of energy expenditure by leptin. Diabetes 53 3067-3073. (doi:10.2337/diabetes.53.12.3067)
    • (2004) Diabetes , vol.53 , pp. 3067-3073
    • Bates, S.H.1    Dundon, T.A.2    Seifert, M.3    Carlson, M.4    Maratos-Flier, E.5    Myers, M.G.6
  • 8
    • 17844373625 scopus 로고    scopus 로고
    • Roles for leptin receptor/STAT3-dependent and -independent signals in the regulation of glucose homeostasis
    • Bates SH, Kulkarni RN, Seifert M&Myers MG Jr 2005 Roles for leptin receptor/STAT3-dependent and -independent signals in the regulation of glucose homeostasis. Cell Metabolism 1 169-178. (doi:10.1016/j.cmet.2005.02.001)
    • (2005) Cell Metabolism , vol.1 , pp. 169-178
    • Bates, S.H.1    Kulkarni, R.N.2    Seifert, M.3    Myers, M.G.4
  • 9
    • 0029776030 scopus 로고    scopus 로고
    • The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors
    • Baumann H, Morella KK, White DW, Dembski M, Bailon PS, Kim H, Lai CF & Tartaglia LA 1996 The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors. PNAS 93 8374-8378. (doi:10.1073/pnas.93.16.8374)
    • (1996) PNAS , vol.93 , pp. 8374-8378
    • Baumann, H.1    Morella, K.K.2    White, D.W.3    Dembski, M.4    Bailon, P.S.5    Kim, H.6    Lai, C.F.7    Tartaglia, L.A.8
  • 12
    • 0032014178 scopus 로고    scopus 로고
    • Identification of SOCS-3 as a potential mediator of central leptin resistance
    • Bjorbaek C, Elmquist JK, Frantz JD, Shoelson SE&Flier JS 1998b Identification of SOCS-3 as a potential mediator of central leptin resistance. Molecular Cell 1 619-625. (doi:10.1016/S1097-2765(00)80062-3)
    • (1998) Molecular Cell , vol.1 , pp. 619-625
    • Bjorbaek, C.1    Elmquist, J.K.2    Frantz, J.D.3    Shoelson, S.E.4    Flier, J.S.5
  • 17
    • 13344259300 scopus 로고    scopus 로고
    • Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice
    • Chen H, Charlat O, Tartaglia LA, Woolf EA, Weng X, Ellis SJ, Lakey ND, Culpepper J, Moore KJ, Breitbart RE et al. 1996 Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 84 491-495. (doi:10.1016/S0092-8674(00)81294-5)
    • (1996) Cell , vol.84 , pp. 491-495
    • Chen, H.1    Charlat, O.2    Tartaglia, L.A.3    Woolf, E.A.4    Weng, X.5    Ellis, S.J.6    Lakey, N.D.7    Culpepper, J.8    Moore, K.J.9    Breitbart, R.E.10
  • 18
    • 0030028959 scopus 로고    scopus 로고
    • Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor
    • Chua SC Jr, Chung WK, Wu-Peng XS, Zhang Y, Liu SM, Tartaglia L & Leibel RL 1996 Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science 271 994-996. (doi:10.1126/science.271.5251.994)
    • (1996) Science , vol.271 , pp. 994-996
    • Chua, S.C.1    Chung, W.K.2    Wu-Peng, X.S.3    Zhang, Y.4    Liu, S.M.5    Tartaglia, L.6    Leibel, R.L.7
  • 19
    • 0030685790 scopus 로고    scopus 로고
    • Fine structure of the murine leptin receptor gene: splice site suppression is required to form two alternatively spliced transcripts
    • Chua SC Jr, Koutras IK, Han L, Liu SM, Kay J, Young SJ, Chung WK & Leibel RL 1997 Fine structure of the murine leptin receptor gene: splice site suppression is required to form two alternatively spliced transcripts. Genomics 45 264-270. (doi:10.1006/geno.1997.4962)
    • (1997) Genomics , vol.45 , pp. 264-270
    • Chua, S.C.1    Koutras, I.K.2    Han, L.3    Liu, S.M.4    Kay, J.5    Young, S.J.6    Chung, W.K.7    Leibel, R.L.8
  • 20
    • 79959936188 scopus 로고    scopus 로고
    • National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2.7 million participants
    • Danaei G, Finucane MM, Lu Y, Singh GM, Cowan MJ, Paciorek CJ, Lin JK, Farzadfar F, Khang YH, Stevens GA et al. 2011 National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2.7 million participants. Lancet 378 31-40. (doi:10.1016/S0140-6736(11)60679-X)
    • (2011) Lancet , vol.378 , pp. 31-40
    • Danaei, G.1    Finucane, M.M.2    Lu, Y.3    Singh, G.M.4    Cowan, M.J.5    Paciorek, C.J.6    Lin, J.K.7    Farzadfar, F.8    Khang, Y.H.9    Stevens, G.A.10
  • 21
    • 0030793449 scopus 로고    scopus 로고
    • Ligand-independent dimerization of the extracellular domain of the leptin receptor and determination of the stoichiometry of leptin binding
    • Devos R, Guisez Y, Van der Heyden J, White DW, Kalai M, Fountoulakis M & Plaetinck G 1997 Ligand-independent dimerization of the extracellular domain of the leptin receptor and determination of the stoichiometry of leptin binding. Journal of Biological Chemistry 272 18304-18310. (doi:10.1074/jbc.272.29.18304)
    • (1997) Journal of Biological Chemistry , vol.272 , pp. 18304-18310
    • Devos, R.1    Guisez, Y.2    Van der Heyden, J.3    White, D.W.4    Kalai, M.5    Fountoulakis, M.6    Plaetinck, G.7
  • 22
    • 6344243617 scopus 로고    scopus 로고
    • SH2-B promotes insulin receptor substrate 1 (IRS1)- and IRS2-mediated activation of the phosphatidylinositol 3-kinase pathway in response to leptin
    • Duan C, Li M&Rui L 2004 SH2-B promotes insulin receptor substrate 1 (IRS1)- and IRS2-mediated activation of the phosphatidylinositol 3-kinase pathway in response to leptin. Journal of Biological Chemistry 279 43684-43691. (doi:10.1074/jbc.M408495200)
    • (2004) Journal of Biological Chemistry , vol.279 , pp. 43684-43691
    • Duan, C.1    Li, M.2    Rui, L.3
  • 28
    • 0028793697 scopus 로고
    • Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action
    • Frederich RC, Hamann A, Anderson S, Lollmann B, Lowell BB&Flier JS 1995a Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nature Medicine 1 1311-1314. (doi:10.1038/nm1295-1311)
    • (1995) Nature Medicine , vol.1 , pp. 1311-1314
    • Frederich, R.C.1    Hamann, A.2    Anderson, S.3    Lollmann, B.4    Lowell, B.B.5    Flier, J.S.6
  • 30
    • 0032558725 scopus 로고    scopus 로고
    • Leptin and the regulation of body weight in mammals
    • Friedman JM&Halaas JL 1998 Leptin and the regulation of body weight in mammals. Nature 395 763-770. (doi:10.1038/27376)
    • (1998) Nature , vol.395 , pp. 763-770
    • Friedman, J.M.1    Halaas, J.L.2
  • 31
    • 1842584949 scopus 로고    scopus 로고
    • Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation
    • Gao Q, Wolfgang MJ, Neschen S, Morino K, Horvath TL, Shulman GI & Fu XY 2004 Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation. PNAS 101 4661-4666. (doi:10.1073/pnas.0303992101)
    • (2004) PNAS , vol.101 , pp. 4661-4666
    • Gao, Q.1    Wolfgang, M.J.2    Neschen, S.3    Morino, K.4    Horvath, T.L.5    Shulman, G.I.6    Fu, X.Y.7
  • 33
    • 46349110307 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription-3 is required in hypothalamic agouti-related protein/neuropeptide Y neurons for normal energy homeostasis
    • Gong L, Yao F, Hockman K, Heng HH, Morton GJ, Takeda K, Akira S, Low MJ, Rubinstein M&MacKenzie RG 2008 Signal transducer and activator of transcription-3 is required in hypothalamic agouti-related protein/neuropeptide Y neurons for normal energy homeostasis. Endocrinology 149 3346-3354. (doi:10.1210/en.2007-0945)
    • (2008) Endocrinology , vol.149 , pp. 3346-3354
    • Gong, L.1    Yao, F.2    Hockman, K.3    Heng, H.H.4    Morton, G.J.5    Takeda, K.6    Akira, S.7    Low, M.J.8    Rubinstein, M.9    MacKenzie, R.G.10
  • 36
    • 72649103549 scopus 로고    scopus 로고
    • Endogenous leptin signaling in the caudal nucleus tractus solitarius and area postrema is required for energy balance regulation
    • Hayes MR, Skibicka KP, Leichner TM, Guarnieri DJ, DiLeone RJ, Bence KK & Grill HJ 2010 Endogenous leptin signaling in the caudal nucleus tractus solitarius and area postrema is required for energy balance regulation. Cell Metabolism 11 77-83. (doi:10.1016/j.cmet.2009.10.009)
    • (2010) Cell Metabolism , vol.11 , pp. 77-83
    • Hayes, M.R.1    Skibicka, K.P.2    Leichner, T.M.3    Guarnieri, D.J.4    DiLeone, R.J.5    Bence, K.K.6    Grill, H.J.7
  • 41
    • 57449099877 scopus 로고    scopus 로고
    • Tyrosine-dependent and -independent actions of leptin receptor in control of energy balance and glucose homeostasis
    • Jiang L, You J, Yu X, Gonzalez L, Yu Y, Wang Q, Yang G, Li W, Li C&Liu Y 2008 Tyrosine-dependent and -independent actions of leptin receptor in control of energy balance and glucose homeostasis. PNAS 105 18619-18624. (doi:10.1073/pnas.0804589105)
    • (2008) PNAS , vol.105 , pp. 18619-18624
    • Jiang, L.1    You, J.2    Yu, X.3    Gonzalez, L.4    Yu, Y.5    Wang, Q.6    Yang, G.7    Li, W.8    Li, C.9    Liu, Y.10
  • 42
    • 0033395851 scopus 로고    scopus 로고
    • Decreased transport of leptin across the blood-brain barrier in rats lacking the short form of the leptin receptor
    • Kastin AJ, Pan W, Maness LM, Koletsky RJ&Ernsberger P 1999 Decreased transport of leptin across the blood-brain barrier in rats lacking the short form of the leptin receptor. Peptides 20 1449-1453. (doi:10.1016/S0196-9781(99)00156-4)
    • (1999) Peptides , vol.20 , pp. 1449-1453
    • Kastin, A.J.1    Pan, W.2    Maness, L.M.3    Koletsky, R.J.4    Ernsberger, P.5
  • 44
    • 0034457883 scopus 로고    scopus 로고
    • In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: overlapping but distinct pathways from insulin
    • Kim YB, Uotani S, Pierroz DD, Flier JS&Kahn BB 2000 In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: overlapping but distinct pathways from insulin. Endocrinology 141 2328-2339.
    • (2000) Endocrinology , vol.141 , pp. 2328-2339
    • Kim, Y.B.1    Uotani, S.2    Pierroz, D.D.3    Flier, J.S.4    Kahn, B.B.5
  • 51
    • 72049111492 scopus 로고    scopus 로고
    • Acute administration of leptin produces anxiolytic-like effects: a comparison with fluoxetine
    • Liu J, Garza JC, Bronner J, Kim CS, Zhang W&Lu XY 2010 Acute administration of leptin produces anxiolytic-like effects: a comparison with fluoxetine. Psychopharmacology 207 535-545. (doi:10.1007/s00213-009-1684-3)
    • (2010) Psychopharmacology , vol.207 , pp. 535-545
    • Liu, J.1    Garza, J.C.2    Bronner, J.3    Kim, C.S.4    Zhang, W.5    Lu, X.Y.6
  • 52
    • 80053131293 scopus 로고    scopus 로고
    • Selective deletion of the leptin receptor in dopamine neurons produces anxiogenic-like behavior and increases dopaminergic activity in amygdala
    • Liu J, Perez SM, Zhang W, Lodge DJ&Lu XY 2011 Selective deletion of the leptin receptor in dopamine neurons produces anxiogenic-like behavior and increases dopaminergic activity in amygdala. Molecular Psychiatry 16 1024-1038. (doi:10.1038/mp.2011.36)
    • (2011) Molecular Psychiatry , vol.16 , pp. 1024-1038
    • Liu, J.1    Perez, S.M.2    Zhang, W.3    Lodge, D.J.4    Lu, X.Y.5
  • 53
    • 31944437527 scopus 로고    scopus 로고
    • Leptin: a potential novel antidepressant
    • Lu XY, Kim CS, Frazer A&Zhang W 2006 Leptin: a potential novel antidepressant. PNAS 103 1593-1598. (doi:10.1073/pnas.0508901103)
    • (2006) PNAS , vol.103 , pp. 1593-1598
    • Lu, X.Y.1    Kim, C.S.2    Frazer, A.3    Zhang, W.4
  • 59
    • 77954894901 scopus 로고    scopus 로고
    • Critical role of the Src homology 2 (SH2) domain of neuronal SH2B1 in the regulation of body weight and glucose homeostasis in mice
    • Morris DL, Cho KW&Rui L 2010 Critical role of the Src homology 2 (SH2) domain of neuronal SH2B1 in the regulation of body weight and glucose homeostasis in mice. Endocrinology 151 3643-3651. (doi:10.1210/en.2010-0254)
    • (2010) Endocrinology , vol.151 , pp. 3643-3651
    • Morris, D.L.1    Cho, K.W.2    Rui, L.3
  • 61
    • 0038747134 scopus 로고    scopus 로고
    • Role of signal transducer and activator of transcription 3 in regulation of hypothalamic proopiomelanocortin gene expression by leptin
    • Munzberg H, Huo L, Nillni EA, Hollenberg AN&Bjorbaek C 2003 Role of signal transducer and activator of transcription 3 in regulation of hypothalamic proopiomelanocortin gene expression by leptin. Endocrinology 144 2121-2131. (doi:10.1210/en.2002-221037)
    • (2003) Endocrinology , vol.144 , pp. 2121-2131
    • Munzberg, H.1    Huo, L.2    Nillni, E.A.3    Hollenberg, A.N.4    Bjorbaek, C.5
  • 62
    • 58749086043 scopus 로고    scopus 로고
    • The geometry of leptin action in the brain: more complicated than a simple ARC
    • Myers MG Jr, Munzberg H, Leinninger GM & Leshan RL 2009 The geometry of leptin action in the brain: more complicated than a simple ARC. Cell Metabolism 9 117-123. (doi:10.1016/j.cmet.2008.12.001)
    • (2009) Cell Metabolism , vol.9 , pp. 117-123
    • Myers, M.G.1    Munzberg, H.2    Leinninger, G.M.3    Leshan, R.L.4
  • 64
    • 84874236315 scopus 로고    scopus 로고
    • Modulation of AgRP-neuronal function by SOCS3 as an initiating event in diet-induced hypothalamic leptin resistance
    • Olofsson LE, Unger EK, Cheung CC&Xu AW 2013 Modulation of AgRP-neuronal function by SOCS3 as an initiating event in diet-induced hypothalamic leptin resistance. PNAS 110 E697-E706. (doi:10.1073/pnas.1218284110)
    • (2013) PNAS , vol.110 , pp. E697-E706
    • Olofsson, L.E.1    Unger, E.K.2    Cheung, C.C.3    Xu, A.W.4
  • 65
    • 79951948090 scopus 로고    scopus 로고
    • Molecular mapping of mouse brain regions innervated by leptin receptorexpressing cells
    • Patterson CM, Leshan RL, Jones JC&Myers MG Jr 2011 Molecular mapping of mouse brain regions innervated by leptin receptorexpressing cells. Brain Research 1378 18-28. (doi:10.1016/j.brainres.2011.01.010)
    • (2011) Brain Research , vol.1378 , pp. 18-28
    • Patterson, C.M.1    Leshan, R.L.2    Jones, J.C.3    Myers, M.G.4
  • 67
    • 40849124301 scopus 로고    scopus 로고
    • Specific physiological roles for Stat3 in leptin receptor-expressing neurons
    • Piper ML, Unger EK, Myers MG Jr&Xu AW 2007 Specific physiological roles for Stat3 in leptin receptor-expressing neurons. Molecular Endocrinology 22 751-759. (doi:10.1210/me.2007-0389)
    • (2007) Molecular Endocrinology , vol.22 , pp. 751-759
    • Piper, M.L.1    Unger, E.K.2    Myers, M.G.3    Xu, A.W.4
  • 68
    • 84896831435 scopus 로고    scopus 로고
    • Leptin acts independently of food intake to modulate gut microbial composition in male mice
    • Rajala MW, Patterson CM, Opp JS, Foltin SK, Young VB&Myers MG Jr 2014 Leptin acts independently of food intake to modulate gut microbial composition in male mice. Endocrinology 155 748-757. (doi:10.1210/en.2013-1085)
    • (2014) Endocrinology , vol.155 , pp. 748-757
    • Rajala, M.W.1    Patterson, C.M.2    Opp, J.S.3    Foltin, S.K.4    Young, V.B.5    Myers, M.G.6
  • 69
    • 77951194676 scopus 로고    scopus 로고
    • Functional role of suppressor of cytokine signaling 3 upregulation in hypothalamic leptin resistance and long-term energy homeostasis
    • Reed AS, Unger EK, Olofsson LE, Piper ML, Myers MG Jr&Xu AW 2010 Functional role of suppressor of cytokine signaling 3 upregulation in hypothalamic leptin resistance and long-term energy homeostasis. Diabetes 59 894-906. (doi:10.2337/db09-1024)
    • (2010) Diabetes , vol.59 , pp. 894-906
    • Reed, A.S.1    Unger, E.K.2    Olofsson, L.E.3    Piper, M.L.4    Myers, M.G.5    Xu, A.W.6
  • 70
    • 25144523930 scopus 로고    scopus 로고
    • Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in mice
    • Ren D, Li M, Duan C&Rui L 2005 Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in mice. Cell Metabolism 2 95-104. (doi:10.1016/j.cmet.2005.07.004)
    • (2005) Cell Metabolism , vol.2 , pp. 95-104
    • Ren, D.1    Li, M.2    Duan, C.3    Rui, L.4
  • 71
    • 77955296183 scopus 로고    scopus 로고
    • Disruption of hypothalamic leptin signaling in mice leads to early-onset obesity, but physiological adaptations in mature animals stabilize adiposity levels
    • Ring LE&Zeltser LM 2010 Disruption of hypothalamic leptin signaling in mice leads to early-onset obesity, but physiological adaptations in mature animals stabilize adiposity levels. Journal of Clinical Investigation 120 2931-2941. (doi:10.1172/JCI41985)
    • (2010) Journal of Clinical Investigation , vol.120 , pp. 2931-2941
    • Ring, L.E.1    Zeltser, L.M.2
  • 75
    • 78650039585 scopus 로고    scopus 로고
    • The hypothalamus and ss-cell connection in the gene-targeting era
    • Schwartz MW, Guyenet SJ&Cirulli V 2010 The hypothalamus and ss-cell connection in the gene-targeting era. Diabetes 59 2991-2993. (doi:10.2337/db10-1149)
    • (2010) Diabetes , vol.59 , pp. 2991-2993
    • Schwartz, M.W.1    Guyenet, S.J.2    Cirulli, V.3
  • 78
    • 84879304955 scopus 로고    scopus 로고
    • Neither signal transducer and activator of transcription 3 (STAT3) or STAT5 signaling pathways are required for leptin's effects on fertility in mice
    • Singireddy AV, Inglis MA, Zuure WA, Kim JS&Anderson GM 2013 Neither signal transducer and activator of transcription 3 (STAT3) or STAT5 signaling pathways are required for leptin's effects on fertility in mice. Endocrinology 154 2434-2445. (doi:10.1210/en.2013-1109)
    • (2013) Endocrinology , vol.154 , pp. 2434-2445
    • Singireddy, A.V.1    Inglis, M.A.2    Zuure, W.A.3    Kim, J.S.4    Anderson, G.M.5
  • 82
    • 84878998921 scopus 로고    scopus 로고
    • Central regulation of metabolism by protein tyrosine phosphatases
    • Tsou RC&Bence KK 2013 Central regulation of metabolism by protein tyrosine phosphatases. Frontiers in Neuroscience 6 192. (doi:10.3389/fnins.2012.00192)
    • (2013) Frontiers in Neuroscience , vol.6 , pp. 192
    • Tsou, R.C.1    Bence, K.K.2
  • 83
    • 84865404028 scopus 로고    scopus 로고
    • Deficiency of PTP1B in leptin receptor-expressing neurons leads to decreased body weight and adiposity in mice
    • Tsou RC, Zimmer DJ, De Jonghe BC&Bence KK 2012 Deficiency of PTP1B in leptin receptor-expressing neurons leads to decreased body weight and adiposity in mice. Endocrinology 153 4227-4237. (doi:10.1210/en.2012-1548)
    • (2012) Endocrinology , vol.153 , pp. 4227-4237
    • Tsou, R.C.1    Zimmer, D.J.2    De Jonghe, B.C.3    Bence, K.K.4
  • 84
    • 84897110775 scopus 로고    scopus 로고
    • Improved metabolic phenotype of hypothalamic PTP1B-deficiency is dependent upon the leptin receptor
    • Tsou RC, Rak KS, Zimmer DJ&Bence KK 2014 Improved metabolic phenotype of hypothalamic PTP1B-deficiency is dependent upon the leptin receptor. Molecular Metabolism 3 301-312. (doi:10.1016/j.molmet.2014.01.008)
    • (2014) Molecular Metabolism , vol.3 , pp. 301-312
    • Tsou, R.C.1    Rak, K.S.2    Zimmer, D.J.3    Bence, K.K.4
  • 85
    • 0031040793 scopus 로고    scopus 로고
    • Leptin receptor (OB-R) signaling. Cytoplasmic domain mutational analysis and evidence for receptor homo-oligomerization
    • White DW, Kuropatwinski KK, Devos R, Baumann H&Tartaglia LA 1997 Leptin receptor (OB-R) signaling. Cytoplasmic domain mutational analysis and evidence for receptor homo-oligomerization. Journal of Biological Chemistry 272 4065-4071. (doi:10.1074/jbc.272.7.4065)
    • (1997) Journal of Biological Chemistry , vol.272 , pp. 4065-4071
    • White, D.W.1    Kuropatwinski, K.K.2    Devos, R.3    Baumann, H.4    Tartaglia, L.A.5
  • 88
    • 33845867730 scopus 로고    scopus 로고
    • Inactivation of signal transducer and activator of transcription 3 in proopiomelanocortin (Pomc) neurons causes decreased pomc expression, mild obesity, and defects in compensatory refeeding
    • Xu AW, Ste-Marie L, Kaelin CB&Barsh GS 2007 Inactivation of signal transducer and activator of transcription 3 in proopiomelanocortin (Pomc) neurons causes decreased pomc expression, mild obesity, and defects in compensatory refeeding. Endocrinology 148 72-80. (doi:10.1210/en.2006-1119)
    • (2007) Endocrinology , vol.148 , pp. 72-80
    • Xu, A.W.1    Ste-Marie, L.2    Kaelin, C.B.3    Barsh, G.S.4
  • 89
    • 2542450776 scopus 로고    scopus 로고
    • Modulation of direct leptin signaling by soluble leptin receptor
    • Yang G, Ge H, Boucher A, Yu X&Li C 2004 Modulation of direct leptin signaling by soluble leptin receptor. Molecular Endocrinology 18 1354-1362. (doi:10.1210/me.2004-0027)
    • (2004) Molecular Endocrinology , vol.18 , pp. 1354-1362
    • Yang, G.1    Ge, H.2    Boucher, A.3    Yu, X.4    Li, C.5
  • 92
    • 69549088269 scopus 로고    scopus 로고
    • The soluble leptin receptor neutralizes leptinmediated STAT3 signalling and anorexic responses in vivo
    • Zhang J&Scarpace PJ 2009 The soluble leptin receptor neutralizes leptinmediated STAT3 signalling and anorexic responses in vivo. British Journal of Pharmacology 158 475-482. (doi:10.1111/j.1476-5381.2009.00246.x)
    • (2009) British Journal of Pharmacology , vol.158 , pp. 475-482
    • Zhang, J.1    Scarpace, P.J.2
  • 93
    • 0028139089 scopus 로고
    • Positional cloning of the mouse obese gene and its human homologue
    • Zhang Y, Proenca R, Maffei M, Barone M, Leopold L&Friedman JM 1994 Positional cloning of the mouse obese gene and its human homologue. Nature 372 425-432. (doi:10.1038/372425a0)
    • (1994) Nature , vol.372 , pp. 425-432
    • Zhang, Y.1    Proenca, R.2    Maffei, M.3    Barone, M.4    Leopold, L.5    Friedman, J.M.6
  • 94
    • 8644268830 scopus 로고    scopus 로고
    • Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism
    • Zhang EE, Chapeau E, Hagihara K&Feng GS 2004 Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism. PNAS 101 16064-16069. (doi:10.1073/pnas.0405041101)
    • (2004) PNAS , vol.101 , pp. 16064-16069
    • Zhang, E.E.1    Chapeau, E.2    Hagihara, K.3    Feng, G.S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.