Development of "substrate-trapping" mutants to identify physiological substrates of protein tyrosine phosphatases

Proceedings of the National Academy of Sciences of the United States of America

Volumn 94, Issue 5, 1997, Pages 1680-1685

  Flint, Andrew J ^a,c   Tiganis, Tony ^a   Barford, David ^b   Tonks, Nicholas K ^a  

^a Simons Center for Quantitative Biology   (United States)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c Charybdis Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; MUTANT PROTEIN; PROTEIN TYROSINE PHOSPHATASE; VANADIC ACID;

ANIMAL CELL; ARTICLE; AUTOPHOSPHORYLATION; BINDING SITE; CELL LINE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; ASPARTIC ACID; BINDING SITES; BINDING, COMPETITIVE; BLOTTING, WESTERN; CELLS, CULTURED; COS CELLS; EPIDERMAL GROWTH FACTOR; HUMANS; KINETICS; MICROSCOPY, FLUORESCENCE; PHOSPHORYLATION; PHOSPHOTYROSINE; PLATELET-DERIVED GROWTH FACTOR; POINT MUTATION; PROTEIN BINDING; PROTEIN-TYROSINE-PHOSPHATASE; RECEPTOR, EPIDERMAL GROWTH FACTOR; SUBSTRATE SPECIFICITY; TRANSFECTION;

ANIMALIA;

EID: 0031055324     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.94.5.1680     Document Type: Article

References (32)

1. Tonks, N. K. & Neel, B. G. (1996) Cell 87, 365-368.
2. Tonks, N. K. (1996) Adv. Pharmacol. 36, 91-119.
3. Barford, D., Jia, Z. & Tonks, N. K. (1995) Nat. Struct. Biol. 2, 1043-1053.
4. Tonks, N. K., Diltz, C. D. & Fischer, E. H. (1988) J. Biol. Chem. 263, 6722-6730.
5. Tonks, N. K., Diltz, C. D. & Fischer, E. H. (1988) J. Biol. Chem. 263, 6731-6737.
6. Guan, K. L., Haun, R. S., Watson, S. J., Geahlen, R. L. & Dixon, J. E. (1990) Proc. Natl. Acad. Sci. USA 87, 1501-1505.
7. Chernoff, J., Schievella, A. R., Jost, C. A., Erikson, R. L. & Neel, B. G. (1990) Proc. Natl. Acad. Sci. USA 87, 2735-2739.
8. Brown-Shimer, S., Johnson, K. A., Lawrence, J. B., Johnson, C. & Bruskin, A. (1990) Proc. Natl. Acad. Sci. USA 87, 5148-5152.
9. Frangioni, J. V., Beahm, P. H., Shifrin, V., Jost, C. A. & Neel, B. G. (1992) Cell 68, 545-560.
10. Flint, A. J., Gebbink, M. F. B. G., Franza, B. R., Jr., Hill, D. E. & Tonks, N. K. (1993) EMBO J. 12, 1937-1946.
11. Barford, D., Flint, A. J. & Tonks, N. K. (1994) Science 263, 1397-1404.
12. Jia, Z., Barford, D., Flint, A. J. & Tonks, N. K. (1995) Science 268, 1754-1758.
13. Stuckey, J. A., Schubert, H. L., Fauman, E. B., Zhang, Z.-Y., Dixon, J. E. & Saper, M. A. (1994) Nature (London) 370, 571-575.
14. Zhang, Z.-Y., Wang, Y. & Dixon, J. E. (1994) Proc. Natl. Acad. Sci. USA 91, 1624-1627.
15. Guan, K. L. & Dixon, J. E. (1991) J. Biol. Chem. 266, 17026-17030.
16. Denu, J. M. & Dixon, J. E. (1995) Proc. Natl. Acad. Sci. USA 92, 5910-5914.
17. Sun, H., Charles, C. H., Lau, L. F. & Tonks, N. K. (1993) Cell 75, 487-493.
18. Shiozaki, K. & Russell, P. (1995) Nature (London) 378, 739-743.
19. Milarski, K. L., Zhu, G., Pearl, C. G., McNamara, D. J., Dobrusin, E. M., MacLean, D., Thieme-Sefler, A., Zhang, Z.-Y., Sawyer, T., Decker, S. J., Dixon, J. E. & Saltiel, A. R. (1993) J. Biol. Chem. 268, 23634-23639.
20. Furukawa, T., Itoh, M., Krueger, N. X., Streuli, M. & Saito, H. (1994) Proc. Natl. Acad. Sci. USA 91, 10928-10932.
21. Kunkel, T. A. (1985) Proc. Natl. Acad. Sci. USA 82, 488-492.
22. Barford, D., Keller, J. C., Flint, A. J. & Tonks, N. K. (1994) J. Mol. Biol. 239, 726-730.
23. Bradford, M. M. (1976) Anal. Biochem. 72, 248-254.
24. Lorenzen, J. A., Dadabay, C. Y. & Fischer, E. H. (1995) J. Cell Biol. 131, 631-643.
25. Zhang, Z.-Y., Wang, Y., Wu, L., Fauman, E. B., Stuckey, J. A., Schubert, H. L., Saper, M. A. & Dixon, J. E. (1994) Biochemistry 33, 15266-15270.
26. Denu, J. M., Lohse, D. L., Vijayalakshmi, J., Saper, M. A. & Dixon, J. E. (1996) Proc. Natl. Acad. Sci. USA 93, 2493-2498.
27. Garton, A. J., Flint, A. J. & Tonks, N. K. (1996) Mol. Cell. Biol. 16, 6408-6418.
28. Bliska, J. B., Clemens, J. C., Dixon, J. E. & Falkow, S. (1992) J. Exp. Med. 176, 1625-1630.
29. Herbst, R., Carroll, P. M., Allard, J. D., Schilling, J., Raabe, T. & Simon, M. A. (1996) Cell 85, 899-909.
30. Hippen, K. L., Jakes, S., Richards, J., Jena, B. P., Beck, B. L., Tabatabai, L. B. & Ingebritsen, T. S. (1993) Biochemistry 32, 12405-12412.
31. Zhang, Z.-Y., Thieme-Sefler, A. M., Maclean, D., McNamara, D. J., Dobrusin, E. M., Sawyer, T. K. & Dixon, J. E. (1993) Proc. Natl. Acad. Sci. USA 90, 4446-4450.
32. Woodford-Thomas, T. A., Rhodes, J. D. & Dixon, J. E. (1992) J. Cell Biol. 117, 401-414.